Summary
[Wormbase] aap-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p50/p55 adaptor/regulatory subunit; AAP-1 negatively regulates lifespan and dauer development, and likely functions as the sole adaptor subunit for the AGE-1/p110 PI3K catalytic subunit to which it binds in vitro; although AAP-1 potentiates insulin-like signaling, it is not absolutely required for insulin-like signaling under most conditions.
Wormbase predicts one model.

AceView summary
According to AceView, this gene is well expressed, 1.1 times the average gene in this release, at all stages, mostly from L1 larvae to adult [Kohara cDNAs], the transcript accumulates in the adult gonad and in early embryos [Kohara in situ hybridisations]; the GFP fusion protein is seen at some level in all tissue, especially neurons and intestine; gonad was not tested by the method [Wolkow, 2002]. The gene is transpliced to SL2, and would be second in an operon with gene 1F675, itself encoding a protein conserved among bilateria, possibly a MAPK activating protein. The sequence of this gene is defined by 14 cDNA clones, some from whole animal (seen 3 times).
The gene contains 4 distinct gt-ag introns. Transcription produces one mRNA. 71 bp of this gene are antisense to spliced gene 1F678, raising the possibility of regulated alternate expression.
The spliced mRNA putatively encodes a good protein, containing SH2 motif [Pfam], a vacuolar domain, a coiled coil stretch [Psort2].
Function: There are 3 articles specifically referring to this gene in PubMed. In addition we point below to 3 abstracts. This gene is associated to a phenotype (constitutive DAuer Formation, long-LIved and Viable after thermal stress, potentiates insulin-like signaling). Proteins are expected to have molecular function (protein binding activity) and to localize in nucleus.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Map: This gene aap-1 maps on chomosome I at position -0.38 (interpolated). In AceView, it covers 2.34 kb, from 5107846 to 5110182 (WS190), on the direct strand.
Links to: WormBase, NextDB, RNAiDB.
Other names: The gene is also known in Wormgenes/AceView by its positional name 1F677, in Wormbase by its cosmid.number name Y110A7A.10, in NextDB, the Nematode expression pattern database, as CEYK6865.

The closest human gene, according to BlastP, is the AceView gene PIK3R1 (e=2 10^-31).
The closest mouse gene, according to BlastP, is the AceView gene Pik3r1 (e=2 10^-31)

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