Homo sapiens gene HIPK4, encoding homeodomain interacting protein kinase 4.
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SUMMARY back to top
RefSeq annotates one representative transcript.

AceView synopsis, each blue text links to tables and details
According to AceView, this gene is well expressed, 0.5 times the average gene in this release. The sequence of this gene is defined by 61 GenBank accessions from 58 cDNA clones, some from testis (seen 39 times), brain (2), medulla (2), adrenal cortex carcinoma, cell line (once), adrenal gland (once), lung (once), nervous normal (once) and 3 other tissues. We annotate structural defects or features in 6 cDNA clones.
The gene contains 3 distinct gt-ag introns. Transcription produces one spliced mRNA, 1 alternatively spliced variant and 1 unspliced form.
Function: There is one article specifically referring to this gene in PubMed. Functionally, the gene has been proposed to participate in a process (protein amino acid phosphorylation). Proteins are expected to have molecular functions (ATP binding, nucleotide binding, protein serine/threonine kinase activity, transferase activity) and to localize in cytoplasm.
Protein coding potential: The spliced mRNAs putatively encode a good protein, containing domains Protein kinase domain, Protein tyrosine kinase [Pfam]. The remaining mRNA variant (unspliced; partial) appears not to encode a good protein. Finally proteins from this gene may be modulated by acetylation; phosphorylation, as detailed at PhosphoSite.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12.
Map on chromosome 19, links to other databases and other names
Map: This gene HIPK4 maps on chromosome 19, at 19q13.2 according to Entrez Gene. In AceView, it covers 11.08 kb, from 40896125 to 40885051 (NCBI 37, August 2010), on the reverse strand.
Links to: manual annotations from PhosphoSite, the SNP view, gene overviews from Entrez Gene 147746, GeneCards, expression data from ECgene, UniGene, molecular and other annotations from UCSC, or our GOLD analysis.
The previous AceView annotation is here.
Other names: The gene is also known as HIPK4 or FLJ32818, LOC147746. It has been described as homeodomain-interacting protein kinase 4.
EC number: This gene encodes protein number: 2.7.11.1.
Closest AceView homologs in other species ?
The closest mouse gene, according to BlastP, is the AceView gene Hipk4 (e=0.0).
The closest C.elegans gene, according to BlastP, is the AceView/WormGene hpk-1 (e=2 10-84), which may contain interesting functional annotation.
The closest A.thaliana gene, according to BlastP, is the AceView gene AT5G35980 (e=4 10-52), which may contain interesting functional annotation
RNA_seq discoveries back to top
Expression/conservation in primates tissues evaluated by cross-mapping to human. back to top
HIPK4 Gene expression in 15 primates, 16 tissues, from the NHPRTR project in sFPKM BAB SkeletalMuscle WholeBlood CHP Kidney Liver Lung Spleen CMC CMM Cerebellum HUM Brain Colon Heart LymphNode Ovary Testis JMI BoneMarrow MLM OWL PTM RMC RMI Pituitary SQM Thymus MST SMY RTL 0.72 2.52 0.29 0.48 2.19 0.26 0.13 0.05 0.10 0.10 0.10 6.21 0.36 0.16 0.18 0.09 0.83 0.19 0.32 0.21 0.10 0.27 0.18 0.13 0.10 0.06 0.08 0.13 0.10 0.10 0.09 0.10 0.06 0.15 1.35 0.24 0.21 4.71 Expression quantiles None Weak 1 2 3 4 5 6 7 8 10 20 This gene All genes log2 distributions RNA-seq gene expression profile across 16 selected tissues from the Non-Human Primates Reference Transcriptome Resource (link to NHPRTR project).
- Primates: Apes (HUM: Human (Illumina BodyMap 2), CHP: Chimpanzee), Old World monkeys (PTM: Pig-Tailed Macaque, JMI Japanese Macaque, RMI Rhesus Macaque Indian, RMC Rhesus Macaque Chinese, CMM Cynomolgus Macaque Mauritian, CMC Cynomolgus Macaque Chinese, BAB Olive Baboon, SMY Sooty Mangabey); New World monkeys (MST common Marmoset, SQM Squirrel Monkey, OWL Owl Monkey); and Lemurs (MLM Mouse Lemur, RTL Ring-Tailed Lemur).
- The level for significantly expressed genes is color coded in 8 equal sized bins (light to dark green). Light gray is for weak not-accurately measured expression (2 to 8 reads above intergenic background); dark gray for no expression or no sequence conservation (0 read in gene). The plot to the right shows the distribution of measured expression values in all tissues for all genes (blue) and for this gene (green), in Magic index = log2(1000 sFPKM).
You may also examine the strand-specific genome coverage plots on the experimental AceView/Magic hub at UCSC, by tissue or by species. Tracks may be slow to load; please reload if some tracks come up yellow-greenish, and thanks to UCSC for the great work!.
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          Complete gene on genome diagram: back to top
Please choose between the zoomable GIF version., and the HTML5/SVG version.
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones.
Compact gene diagram back to top
Gene HIPK4 5' 3' encoded on minus strand of chromosome 19 from 40,896,125 to 40,885,051 33 171 131 a [NM] b-u 1kb 0 781 bp exon 781 bp exon 5298 bp [gt-ag] intron 11 GenBank accessions 22 RNA-seq supporting reads 1 UHR pooled cells 20 Neuroblastoma 1 Other (also 22 Primates bodymap) 357 bp exon 2614 bp [gt-ag] intron 7 GenBank accessions 164 RNA-seq supporting reads 28 UHR pooled cells 1 Brain 6 Blood 127 Neuroblastoma 2 Other (also 28 Primates bodymap) 846 bp exon 553 bp [gt-ag] intron 14 GenBank accessions 117 RNA-seq supporting reads 12 UHR pooled cells 2 Brain 11 Blood 92 Neuroblastoma (also 10 Primates bodymap) 626 bp exon 52 accessions, NM_144685.3 some from testis (seen 34 times) brain (2), medulla (2) adrenal cortex carcinoma cell line (once), adrenal gland (once) capped 5' end, 23 accessions Validated 3' end, 3 accessions 626 bp exon 247 bp exon 247 bp exon 1 accession from nervous normal 247 bp exon Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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Sequences: click on the numbers to get the DNA back to top
mRNA variant mRNA matching the genome Best predicted protein 5' UTR 3' UTR Upstream sequence Transcription
unit
pre-mRNA
Downstream sequence
aAug10 2610 bp 720 aa 316 bp 443 bp 2kb including Promoter 11075 bp 1kb
bAug10-unspliced 247 bp 63 aa 57 bp 2kb 247 bp 1kb

Gene neighbors and Navigator on chromosome 19q13.2 back to top
PSMC4 C I R P ZNF546 C R P R MAP3K10 C I R P PLD3 C I R P R SPTBN4 C I R P SHKBP1 C I R P LTBP4 D C I R P ITPKC D C R P SNRPA D C I R P MIA_ D C I R P C C C G C G C C R P ZNF780AandZNF780B C R TTC9B C R CNTD2 D C I R P AKT2 R C R C19orf47 C P HIPK4 D C I R P PRX D C I R P SERTAD1 C I R P SERTAD3 C I R P BLVRB C I R P NUMBL C R ADCK4 C R C19orf54 C R P CYP2T2P C R P CYP2F1P D C R P CYP2A6 100kb 0 PSMC4, 484 accessions 10 variants ZNF546, 57 accessions 11 variants chysor, 15 accessions MAP3K10, 76 accessions 7 variants PLD3, 590 accessions, 30 variants mychoy, 2 accessions, 2 variants SPTBN4, 72 accessions 17 variants SHKBP1, 580 accessions 29 variants LTBP4, 458 accessions 38 variants ITPKC, 198 accessions 9 variants SNRPA, 304 accessions 12 variants MIA_, 688 accessions, 36 variants verchoy, 3 accessions rineru, 12 accessions soyseybu, 1 accession klujer, 2 accessions klychor, 1 accession klochor, 1 accession sheevo, 1 accession klorchor, 1 accession plachor, 2 accessions plochor, 2 accessions pleychor, 1 accession teyseybu, 10 accessions jawber, 4 accessions toyseybu, 1 accession vyseybu, 2 accessions shorvoy, 2 accessions voyseybu, 1 accession raneru, 1 accession plujer, 1 accession blavoy, 3 accessions skoyjer, 2 accessions snawchor, 1 accession spachor, 1 accession plajar, 1 accession stuchor, 2 accessions stawchor, 1 accession slarvo, 1 accession bluvoy, 6 accessions swerchor, 1 accession bleymee, 1 accession slarjer, 1 accession garchoy, 1 accession choyzor, 3 accessions shuzor, 4 accessions vysarbo, 4 accessions glomee, 3 accessions favar, 1 accession feevar, 1 accession jerchoy, 1 accession blorvoy, 2 accessions jorchoy, 1 accession vosarbo, 2 accessions kloymee, 1 accession keechoy, 2 accessions harari, 2 accessions korchoy, 1 accession lachoy, 5 accessions chuseybu, 2 accessions kavar, 1 accession nawchoy, 2 accessions parchoy, 1 accession novar, 1 accession perchoy, 1 accession slerjer, 1 accession ruvar, 1 accession ruchoy, 2 accessions rarchoy, 1 accession rawchoy, 1 accession chawseybu, 1 accession feyser, 1 accession wawvar, 1 accession cherseybu, 1 accession cheyseybu, 1 accession sochoy, 2 accessions smyjer, 2 accessions soychoy, 1 accession choyseybu, 1 accession smojer, 1 accession kluwy, 10 accessions smumee, 3 accessions zawvar, 1 accession terchoy, 1 accession sheeseybu, 1 accession snarjer, 2 accessions torchoy, 5 accessions chavar, 2 accessions toychoy, 2 accessions sherseybu, 1 accession veesarbo, 3 accessions charvar, 1 accession swoymee, 1 accession vochoy, 2 accessions bumer, 4 accessions cheychoy, 1 accession blaseybu, 1 accession lorber, 17 accessions wychoy, 4 accessions wuchoy, 1 accession bluseybu, 2 accessions bermer, 1 accession warchoy, 1 accession snorjer, 1 accession weechoy, 2 accessions farmer, 1 accession horari, 1 accession klachor, 5 accessions zamee, 2 accessions klerchor, 1 accession kloychor, 1 accession klojer, 1 accession toseybu, 1 accession plychor, 1 accession watore, 1 accession rurari, 1 accession chawtee, 1 accession rerari, 1 accession ratore, 2 accessions, 2 variants terseybu, 1 accession shuvoy, 2 accessions ploychor, 8 accessions skychor, 1 accession blavo, 1 accession vuseybu, 1 accession voseybu, 1 accession varseybu, 1 accession sheyvoy, 7 accessions kloyjer, 1 accession verseybu, 1 accession veyseybu, 2 accessions vorseybu, 1 accession waseybu, 2 accessions wyseybu, 1 accession rorari, 3 accessions shoyvoy, 1 accession woseybu, 1 accession skoychor, 1 accession klorvo, 1 accession pleevo, 2 accessions spawchor, 4 accessions worseybu, 2 accessions spoychor, 1 accession stychor, 1 accession matore, 1 accession stochor, 1 accession starchor, 1 accession zaseybu, 1 accession slyvo, 1 accession mirari, 1 accession stoychor, 1 accession snorvo, 1 accession bachoy, 1 accession jeyber, 1 accession blovoy, 4 accessions zyseybu, 2 accessions spawvo, 1 accession geychoy, 1 accession zoseybu, 5 accessions blawvoy, 2 accessions vasarbo, 3 accessions zawseybu, 1 accession zeeseybu, 1 accession goychoy, 7 accessions tetore, 2 accessions, 2 variants roseebu, 10 accessions ruseebu, 2 accessions stawvo, 3 accessions jychoy, 1 accession glawmee, 4 accessions zorseybu, 1 accession jeychoy, 2 accessions vusarbo, 1 accession karchoy, 1 accession jarvar, 1 accession jeevar, 1 accession koychoy, 15 accessions keeber, 5 accessions jervar, 2 accessions plarmee, 1 accession fyser, 5 accessions moychoy, 1 accession narchoy, 2 accessions movar, 4 accessions mawvar, 2 accessions peechoy, 1 accession ryvar, 2 accessions porchoy, 1 accession rachoy, 1 accession rychoy, 1 accession choseybu, 1 accession toyvar, 1 accession veevar, 1 accession feeser, 1 accession cheeseybu, 1 accession reychoy, 5 accessions rorchoy, 1 accession sychoy, 1 accession worvar, 1 accession zarvar, 1 accession tuchoy, 1 accession tochoy, 1 accession smeyjer, 5 accessions smorjer, 1 accession sneejer, 13 accessions vachoy, 1 accession hirari, 1 accession flavar, 1 accession flyvar, 1 accession vuchoy, 3 accessions snerjer, 3 accessions glovar, 1 accession perwubo, 1 accession wawchoy, 3 accessions fomer, 1 accession weychoy, 1 accession dermer, 3 accessions FCGBP, 298 accessions 7 variants zeysor, 1 accession LOC440525, 65 accessions sheevoy, 3 accessions LOC390933, 2 accessions ZNF780AandZNF780B, 211 accessions 19 variants TTC9B, 76 accessions, 2 variants CNTD2, 25 accessions, 5 variants AKT2, 443 accessions, 34 variants deychoy, 10 accessions 3 variants C19orf47, 118 accessions 13 variants HIPK4, 59 accessions, 2 variants PRX, 75 accessions, 4 variants SERTAD1, 142 accessions SERTAD3, 108 accessions 6 variants BLVRB, 405 accessions 8 variants NUMBL, 181 accessions 12 variants ADCK4, 139 accessions 19 variants C19orf54, 119 accessions 13 variants CYP2T2P, 74 accessions 6 variants CYP2F1P, 6 accessions 4 variants CYP2A6, 222 accessions 5 variants ZOOM IN                D:disease,C:conserved,I:interactions,R:regulation,P:publications         Read more...
Annotated mRNA diagrams back to top
Bibliography:               1 article in PubMed back to top
? Gene Summary Gene on genome mRNA:.a, .b-u Alternative mRNAs features, proteins, introns, exons, sequences Expression Tissue Function, regulation, related genes C

To mine knowledge about the gene, please click the 'Gene Summary' or the 'Function, regulation, related genes ' tab at the top of the page. The 'Gene Summary' page includes all we learnt about the gene, functional annotations of neighboring genes, maps, links to other sites and the bibliography. The 'Function, regulation, related genes ' page includes Diseases (D), Pathways, GO annotations, conserved domains (C), interactions (I) reference into function, and pointers to all genes with the same functional annotation.
To compare alternative variants, their summarized annotations, predicted proteins, introns and exons, or to access any sequence, click the 'Alternative mRNAs features' tab. To see a specific mRNA variant diagram, sequence and annotation, click the variant name in the 'mRNA' tab. To examine expression data from all cDNAs clustered in this gene by AceView, click the 'Expression tissue'.

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