AceView: Gene:PIGZ, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView.

Note that this locus is complex: it appears to produce several proteins with no sequence overlap.
Expression: According to AceView, this gene is well expressed, 0.6 times the average gene in this release. The sequence of this gene is defined by 69 GenBank accessions from 56 cDNA clones, some from skin (seen 9 times), melanotic melanoma, high MDR (cell line) (7), brain (5), colon (3), fetal brain (3), insulinoma (3), lung (3) and 24 other tissues. We annotate structural defects or features in 7 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 4 distinct gt-ag introns. Transcription produces 5 different mRNAs, 4 alternatively spliced variants and 1 unspliced form. There are 2 probable alternative promotors, 2 non overlapping alternative last exons and 4 validated alternative polyadenylation sites (see the diagram).
Function: There are 4 articles specifically referring to this gene in PubMed. Functionally, the gene has been proposed to participate in pathway (Glycosylphosphatidylinositol(GPI)-anchor biosynthesis) and a process (GPI anchor biosynthetic process). Proteins are expected to have molecular functions (alpha-1,2-mannosyltransferase activity, transferase activity, transferring glycosyl groups) and to localize in various compartments (endoplasmic reticulum, endoplasmic reticulum membrane, plasma membrane, integral to membrane, intrinsic to endoplasmic reticulum membrane).
Protein coding potential: 3 spliced mRNAs putatively encode good proteins, altogether 3 different isoforms (3 complete), some containing Alg9-like mannosyltransferase family domain [Pfam], some transmembrane domains [Psort2]. The remaining 2 mRNA variants (1 spliced, 1 unspliced; 1 partial) appear not to encode good proteins. Finally proteins from this gene may be modulated by mono-methylation; phosphorylation, as detailed at PhosphoSite.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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cDNA accession Links to the sequence	Tissue most 5' clones in red	Match mRNA	From bp to bp in mRNA	From bp to bp in accs.	Clone encodes complete protein (with AA variation)	Features	Anomalies detected by AceView	Accession match over (% length)	Base differences relative to genome (% identity)
AK022830		.a	1 to 2686	2 to 2687	A266T R340Q	tiling clone, available from FLJ,		2687/2687 (100 %)	5 diff (99.9 %id)
AK296867	tongue, tumor tissue	.b	1 to 1947	1 to 1947	R190Q	tiling clone,		1947/1947 (100 %)	5 diff (99.8 %id)
AW844517	colon_normal	.a	2246 to 2458	1 to 213				213/220 (96 %)	5 diff (97.8 %id)
AW879342	ovary	.a	1886 to 2421	534 to 5				530/557 (95 %)	0 diff (100 %id)
BC044640	Skin, melanotic melanoma, high MDR.	.a	80 to 2699	1 to 2620	A266T R340Q M487I	tiling clone, available from MGC, AAA	Possibly primed on the genome, locally A rich (17/18 A in genome downstream of last aligned base)	2620/2620 (100 %)	6 diff (99.8 %id)
BE077398	breast	.a	1868 to 2267	584 to 184			Submitted on the opposite strand	401/585 (68 %)	0 diff (100 %id)
BF366960	nervous_tumor	.a	2181 to 2419	249 to 12				238/249 (95 %)	0 diff (100 %id)
BM504224	insulinoma, Pancreas	.c	1261 to 1778	533 to 16		tiling clone, AAA	Possibly primed on the genome, locally A rich (17/18 A in genome downstream of last aligned base)	518/518 (100 %)	0 diff (100 %id)
BM504443	insulinoma, Pancreas	.c	390 to 885	7 to 502				496/502 (98 %)	6 diff (98.9 %id)
BQ320441	colon	.a	1647 to 1896	249 to 1				249/249 (100 %)	3 diff (98.8 %id)
BQ353461	head_neck	.a	2181 to 2419	249 to 12				238/249 (95 %)	0 diff (100 %id)
DA057645	cerebellum	.a	1 to 466	2 to 467		capped		466/467 (99 %)	1 diff (99.8 %id)
DA161202	amygdala	.a	78 to 635	2 to 559		capped		558/558 (100 %)	1 diff (99.9 %id)
BX281271	brain	.a	1911 to 2424	1 to 515				515/515 (100 %)	1 diff (99.9 %id)
CD632502		.a	1135 to 1522	388 to 1				388/388 (100 %)	2 diff (99.5 %id)
CD632503		.a	1135 to 1526	1 to 392				392/393 (99 %)	3 diff (99.3 %id)
CR601084	fetal brain	.c	1 to 1763	1 to 1763	exact	tiling clone,		1763/1763 (100 %)	0 diff (100 %id)
CR747702	skin	.a	1291 to 1794	1 to 504				504/504 (100 %)	0 diff (100 %id)
AL537470	brain, fetal brain	.e-u	450 to 1293	846 to 1		tiling clone,		846/846 (100 %)	15 diff (98.3 %id)
AL537471	brain, fetal brain	.c	1 to 790	1 to 783	V96S P97R P98R P99L P100R ...			783/783 (100 %)	8 diff (99.0 %id)
DC346992	tongue, tumor tissue	.b	1 to 572	1 to 573				573/573 (100 %)	2 diff (99.7 %id)
BX493581		.a	689 to 1205	1 to 517		tiling clone,		517/517 (100 %)	5 diff (99.1 %id)
EL736020	mixed	.a	147 to 729	1 to 583				583/583 (100 %)	1 diff (99.9 %id)
EL952619	eyeball	.a	1438 to 1960	1 to 523				523/525 (99 %)	6 diff (98.9 %id)
FN158929	breast carcinoma	.a	2098 to 2178	80 to 1			Submitted on the opposite strand	80/81 (98 %)	1 diff (98.8 %id)
AV646646	corresponding non cancerous liver tissue	.c	1149 to 1778	1 to 630		AAA	Submitted on the opposite strand	630/630 (100 %)	10 diff (98.5 %id)
BP263233	small intestine	.c	368 to 941	1 to 575				575/575 (100 %)	3 diff (99.5 %id)
R19260	liver and spleen	.e-u	315 to 524	210 to 1		tiling clone,		210/219 (95 %)	0 diff (100 %id)
AA569801	breast	.c	843 to 955	113 to 1				113/113 (100 %)	2 diff (98.3 %id)
AI720601	colon	.a	1725 to 2227	506 to 4				503/506 (99 %)	0 diff (100 %id)
BE348708	carcinoid, lung	.a	1802 to 2225	424 to 1				424/424 (100 %)	0 diff (100 %id)
BF001481	colon, colon tumor, RER+	.c	546 to 995	455 to 6				450/455 (98 %)	0 diff (100 %id)
BF111797	pooled	.a	2247 to 2687	445 to 5				441/445 (99 %)	0 diff (100 %id)
BG742845	skin	.a	1292 to 1965	1 to 673				673/673 (100 %)	6 diff (99.2 %id)
BG760211	melanotic melanoma, high MDR (cell line), skin	.a	98 to 857	1 to 760				760/760 (100 %)	2 diff (99.8 %id)
BG760692	melanotic melanoma, high MDR (cell line), skin	.a	98 to 1022	1 to 922				922/952 (96 %)	32 diff (96.7 %id)
BC018804	Skin, melanotic melanoma, high MDR.	.a	81 to 2699	1 to 2619	A266T R340Q M487I	tiling clone, available from MGC, AAA	Possibly primed on the genome, locally A rich (17/18 A in genome downstream of last aligned base)	2619/2619 (100 %)	6 diff (99.8 %id)
BG770568	melanotic melanoma, high MDR (cell line), skin	.a	98 to 934	1 to 839		available from MGC,		839/840 (99 %)	24 diff (97.2 %id)
BG763440	melanotic melanoma, high MDR (cell line), skin	.a	98 to 1012	1 to 908				908/940 (96 %)	30 diff (96.9 %id)
BG763689	melanotic melanoma, high MDR (cell line), skin	.a	98 to 864	1 to 772				772/773 (99 %)	12 diff (98.5 %id)
BG769975	melanotic melanoma, high MDR (cell line), skin	.a	98 to 994	1 to 899				899/910 (98 %)	46 diff (95.0 %id)
BG767520	melanotic melanoma, high MDR (cell line), skin	.a	98 to 1002	1 to 902				902/902 (100 %)	29 diff (96.8 %id)
BI757996	brain	.a	1911 to 2669	1 to 760				760/766 (99 %)	7 diff (99.1 %id)
CK905495	insulinoma, Pancreas	.c	390 to 943	7 to 561				555/561 (98 %)	7 diff (98.8 %id)
TI_57221345		.a	1911 to 2669	29 to 788				760/794 (95 %)	7 diff (99.2 %id)
D45572	lung	.a	2474 to 2687	1 to 214			Submitted on the opposite strand	214/216 (99 %)	1 diff (99.6 %id)
NM_025163.2		.a	1 to 2699	2 to 2700	exact	RefSeq, AAA	Possibly primed on the genome, locally A rich (17/18 A in genome downstream of last aligned base)	2700/2700 (100 %)	0 diff (100 %id)
AU127569		.a	1 to 686	2 to 688		capped		687/687 (100 %)	16 diff (97.7 %id)
AU150122		.a	2418 to 2686	269 to 1				269/269 (100 %)	2 diff (99.3 %id)
AU153339		.d	1863 to 2414	560 to 1		tiling clone,		560/560 (100 %)	10 diff (98.3 %id)
DA736224		.d	1 to 674	2 to 680	exact	tiling clone, capped		679/686 (98 %)	11 diff (98.4 %id)
DA776814	brain	.a	1 to 511	2 to 512		capped		511/511 (100 %)	0 diff (100 %id)
BM833053	stomach	.e-u	1 to 559	1 to 559	exact	tiling clone,		559/559 (100 %)	3 diff (99.5 %id)
TI_1948225777		.a	147 to 1013	125 to 1003		tiling clone,		878/1314 (66 %)	33 diff (97.5 %id)
TI_1948225778		.a	1053 to 1885	964 to 124				841/1304 (64 %)	0 diff (100 %id)
TI_1948225917		.a	147 to 948	121 to 931		fully sequenced,		810/930 (87 %)	12 diff (98.8 %id)
TI_1948225918		.a	918 to 1893	1097 to 116		fully sequenced,		982/1097 (89 %)	52 diff (95.3 %id)
TI_1948226064		.a	147 to 1051	122 to 1034		fully sequenced,		912/1033 (88 %)	28 diff (97.3 %id)
TI_1948226065		.a	1021 to 1893	998 to 116		tiling clone, fully sequenced,		883/998 (88 %)	33 diff (96.7 %id)
TI_1948226211		.a	147 to 1033	127 to 1021		tiling clone,		894/1279 (69 %)	36 diff (97.2 %id)
TI_1948226212		.a	1191 to 1885	824 to 123				702/1443 (48 %)	0 diff (100 %id)
BU754440	placenta	.a	2258 to 2673	432 to 17		AAA	Possibly primed on the genome, locally A rich (17/18 A in genome downstream of last aligned base)	416/416 (100 %)	2 diff (99.6 %id)
BQ025743	placenta	.a	2268 to 2677	424 to 15				410/424 (96 %)	0 diff (100 %id)
CA313131	Human Lung Epithelial cells, lung	.a	1570 to 2226	675 to 19		AAA	Possibly primed on the genome, locally A rich (17/18 A in genome downstream of last aligned base)	657/657 (100 %)	0 diff (100 %id)
BQ185226	eye, fetal eyes, lens, eye anterior segment,optic nerve, retina, Retina Foveal and Macular, RPE andChoroid	.c	759 to 956	217 to 19		fully sequenced, AAA		199/199 (100 %)	1 diff (99.5 %id)
BQ187990	eye, fetal eyes, lens, eye anterior segment,optic nerve, retina, Retina Foveal and Macular, RPE andChoroid	.c	573 to 956	1 to 383		fully sequenced, AAA		383/383 (100 %)	1 diff (99.8 %id)
DA196935	amygdala	.e-u	1 to 559	1 to 559		tiling clone, capped		559/559 (100 %)	3 diff (99.5 %id)
DB303609	amygdala	.a	147 to 1013	125 to 1003		tiling clone,		878/1314 (66 %)	33 diff (97.5 %id)
DB289818	uterus	.a	1053 to 1885	964 to 124		capped		841/1304 (64 %)	0 diff (100 %id)
TI_1948225917		.a	147 to 948	121 to 931		fully sequenced,		810/930 (87 %)	12 diff (98.8 %id)
TI_1948225918		.a	918 to 1893	1097 to 116		fully sequenced,		982/1097 (89 %)	52 diff (95.3 %id)
TI_1948226064		.a	147 to 1051	122 to 1034		fully sequenced,		912/1033 (88 %)	28 diff (97.3 %id)
TI_1948226065		.a	1021 to 1893	998 to 116		tiling clone, fully sequenced,		883/998 (88 %)	33 diff (96.7 %id)
TI_1948226211		.a	147 to 1033	127 to 1021		tiling clone,		894/1279 (69 %)	36 diff (97.2 %id)
TI_1948226212		.a	1191 to 1885	824 to 123				702/1443 (48 %)	0 diff (100 %id)
BU754440	placenta	.a	2258 to 2673	432 to 17		AAA	Possibly primed on the genome, locally A rich (17/18 A in genome downstream of last aligned base)	416/416 (100 %)	2 diff (99.6 %id)
BQ025743	placenta	.a	2268 to 2677	424 to 15				410/424 (96 %)	0 diff (100 %id)
CA313131	Human Lung Epithelial cells, lung	.a	1570 to 2226	675 to 19		AAA	Possibly primed on the genome, locally A rich (17/18 A in genome downstream of last aligned base)	657/657 (100 %)	0 diff (100 %id)
CA313131	Human Lung Epithelial cells, lung	.a	1570 to 2226	675 to 19		AAA	Possibly primed on the genome, locally A rich (17/18 A in genome downstream of last aligned base)	657/657 (100 %)	0 diff (100 %id)
BQ185226	eye, fetal eyes, lens, eye anterior segment,optic nerve, retina, Retina Foveal and Macular, RPE andChoroid	.c	759 to 956	217 to 19		fully sequenced, AAA		199/199 (100 %)	1 diff (99.5 %id)
BQ185226	eye, fetal eyes, lens, eye anterior segment,optic nerve, retina, Retina Foveal and Macular, RPE andChoroid	.c	759 to 956	217 to 19		fully sequenced, AAA		199/199 (100 %)	1 diff (99.5 %id)
BQ187990	eye, fetal eyes, lens, eye anterior segment,optic nerve, retina, Retina Foveal and Macular, RPE andChoroid	.c	573 to 956	1 to 383		fully sequenced, AAA		383/383 (100 %)	1 diff (99.8 %id)
BQ187990	eye, fetal eyes, lens, eye anterior segment,optic nerve, retina, Retina Foveal and Macular, RPE andChoroid	.c	573 to 956	1 to 383		fully sequenced, AAA		383/383 (100 %)	1 diff (99.8 %id)