Note that this locus is complex: it appears to produce several proteins with no sequence overlap, and it merges 2 different NCBI genes.
Expression: According to AceView, this gene is expressed at very high level, 5.4 times the average gene in this release. The sequence of this gene is defined by 620 GenBank accessions from 568 cDNA clones, some from colon (seen 34 times), brain (31), lung (27), placenta (21), placenta cot 25-normalized (18), uterus (18), pancreas (16) and 140 other tissues. We annotate structural defects or features in 76 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 57 distinct introns (55 gt-ag, 1 gc-ag, 1 other). Transcription produces 38 different mRNAs, 30 alternatively spliced variants and 8 unspliced forms. There are 13 probable alternative promotors, 9 non overlapping alternative last exons and 12 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 33 cassette exons, overlapping exons with different boundaries, splicing versus retention of 2 introns.
3 variants were isolated in vivo, despite the fact that they are predicted targets of nonsense mediated mRNA decay (NMD).
Efficacy of translation may be reduced by the presence of a shorter translated product (uORF) initiating at an AUG upstream of the main open reading frame (in variant fAug10, hAug10, kAug10, rAug10).
Function: There are 52 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to diseases (Breast Neoplasms; Carcinoma, Squamous Cell; Hodgkin Disease; Leukemia) and proposed to participate in a process (protein amino acid phosphorylation). Proteins are expected to have molecular functions (ATP binding, metal ion binding, protein serine/threonine kinase activity, sugar binding) and to localize in various compartments (cytoplasm, mitochondrion, nucleus, extracellular region, intracellular, membrane). Putative protein interactors have been described (CTNNB1, EPHB2, JUP, MAP2K1, MAPK1, MARK3, NME1-NME2, RAF1, SLC1A5, YWHAZ).
Protein coding potential: 28 spliced and 3 unspliced mRNAs putatively encode good proteins, altogether 31 different isoforms (22 complete, 1 COOH complete, 8 partial), some containing domains Phorbol esters/diacylglycerol binding domain (C1 domain), Galactoside-binding lectin, Protein kinase domain, Protein tyrosine kinase [Pfam], a vacuolar domain [Psort2]. The remaining 7 mRNA variants (2 spliced, 5 unspliced; 2 partial) appear not to encode good proteins. Finally proteins from this gene may be modulated by phosphorylation, as detailed at PhosphoSite. Finally proteins from this gene may be modulated by acetylation; phosphorylation, as detailed at PhosphoSite.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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