AceView: Gene:JSRP1, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView.

Expression: According to AceView, this gene is moderately expressed, only 38.8% of the average gene in this release. The sequence of this gene is defined by 44 GenBank accessions from 43 cDNA clones, some from skeletal muscle (seen 7 times), muscle (5), rhabdomyosarcoma (5), pectoral muscle (after mastectomy) (3), adenocarcinoma cell line (2), carcinoid (2), colon (2) and 15 other tissues.
Alternative mRNA variants and regulation: The gene contains 8 distinct gt-ag introns. Transcription produces 3 alternatively spliced mRNAs. There are 2 probable alternative promotors and 2 non overlapping alternative last exons (see the diagram). The mRNAs appear to differ by truncation of the 3' end. 234 bp of this gene are antisense to spliced gene OAZ1andSPPL2B, raising the possibility of regulated alternate expression.
Function: There are 3 articles specifically referring to this gene in PubMed. Proteins are expected to localize in various compartments (nuclear membrane, sarcoplasmic reticulum membrane). No phenotype has yet been reported to our knowledge: this gene's in vivo function is yet unknown.
Protein coding potential: 2 spliced mRNAs putatively encode good proteins, altogether 2 different isoforms (1 complete, 1 partial), containing some transmembrane domains [Psort2], apparently mammals specific. The remaining mRNA variant (spliced; partial) appears not to encode a good protein.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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cDNA accession Links to the sequence	Tissue most 5' clones in red	Match mRNA	From bp to bp in mRNA	From bp to bp in accs.	Clone encodes complete protein (with AA variation)	Features	Anomalies detected by AceView	Accession match over (% length)	Base differences relative to genome (% identity)
NM_144616.3		.a	1 to 1145	1 to 1145	exact	RefSeq,		1145/1145 (100 %)	0 diff (100 %id)
DA897543	skeletal muscle	.a	1 to 548	2 to 549		tiling clone, capped		548/548 (100 %)	1 diff (99.9 %id)
AK056978	skeletal muscle	.a	7 to 1143	1 to 1137	exact	available from FLJ,		1137/1137 (100 %)	1 diff (100.0 %id)
DA893634	skeletal muscle	.a	8 to 527	2 to 521		capped		520/520 (100 %)	1 diff (99.9 %id)
DA893108	skeletal muscle	.a	11 to 344	2 to 332		capped		331/485 (68 %)	2 diff (99.6 %id)
BG827814	muscle, rhabdomyosarcoma	.a	16 to 855	1 to 846				846/853 (99 %)	34 diff (96.1 %id)
BM474204	leiomyosarcoma, uterus	.a	17 to 866	1 to 857				857/1021 (83 %)	23 diff (97.8 %id)
DA898560	skeletal muscle	.a	28 to 532	2 to 506		tiling clone, capped		505/505 (100 %)	1 diff (99.9 %id)
BQ685035	ductal carcinoma, cell line, Pancreas	.a	35 to 835	10 to 814				809/876 (92 %)	33 diff (96.3 %id)
DA894163	skeletal muscle	.a	35 to 507	11 to 483		capped		477/487 (97 %)	8 diff (98.4 %id)
DA898323	skeletal muscle	.a	35 to 584	12 to 563		capped		556/556 (100 %)	8 diff (98.6 %id)
BF204446	muscle, rhabdomyosarcoma	.a	36 to 756	1 to 713				713/735 (97 %)	18 diff (97.6 %id)
BF306204	muscle, rhabdomyosarcoma	.a	36 to 798	1 to 743				719/929 (77 %)	37 diff (96.1 %id)
BF307336	muscle, rhabdomyosarcoma	.a	36 to 782	1 to 733				734/745 (98 %)	55 diff (92.7 %id)
BG827699	muscle, rhabdomyosarcoma	.a	36 to 764	1 to 724				723/726 (99 %)	34 diff (95.4 %id)
DR006820	Spleen	.a	36 to 653	12 to 635				630/635 (99 %)	12 diff (98.2 %id)
BC021201	Muscle, rhabdomyosarcoma	.a	37 to 1143	1 to 1107	exact	tiling clone, available from MGC, AAA		1107/1107 (100 %)	4 diff (99.7 %id)
BE746917	adenocarcinoma cell line, ovary	.a	61 to 880	1 to 803				803/837 (95 %)	22 diff (97.4 %id)
BE743731	adenocarcinoma cell line, ovary	.a	62 to 908	1 to 836				836/852 (98 %)	25 diff (97.1 %id)
TI_1948241204		.a	71 to 1006	137 to 1072				936/1391 (67 %)	62 diff (95.6 %id)
TI_1948241205		.a	71 to 842	123 to 894				772/1338 (57 %)	34 diff (97.5 %id)
EL733406	mixed	.a	72 to 741	1 to 668				668/675 (98 %)	4 diff (99.5 %id)
AI805145	B-cell, chronic lymphotic leukemia	.a	336 to 1144	812 to 4				809/959 (84 %)	17 diff (98.3 %id)
TI_1948241206		.a	507 to 1070	692 to 129				565/1331 (42 %)	10 diff (99.3 %id)
TI_1948241207		.a	507 to 1070	688 to 124				565/1409 (40 %)	11 diff (99.3 %id)
TI_1948240632		.a	599 to 1066	1067 to 600			Submitted on the opposite strand	468/1289 (36 %)	0 diff (100 %id)
TI_1948240924		.a	599 to 1066	1061 to 599			Submitted on the opposite strand	463/1271 (36 %)	0 diff (100 %id)
TI_1948240923		.a	602 to 1066	1070 to 591			Submitted on the opposite strand	480/1418 (33 %)	0 diff (100 %id)
DB330913	skeletal muscle	.a	623 to 1143	521 to 1				521/521 (100 %)	0 diff (100 %id)
TI_1948240631		.a	636 to 1066	1031 to 596			Submitted on the opposite strand	436/1427 (30 %)	0 diff (100 %id)
AA628755		.a	660 to 1122	462 to 1				462/462 (100 %)	5 diff (99.0 %id)
TI_1948240368		.a	705 to 1066	958 to 596			Submitted on the opposite strand	363/1304 (27 %)	0 diff (100 %id)
F35910	pectoral muscle (after mastectomy)	.a	715 to 994	1 to 280				280/280 (100 %)	7 diff (97.5 %id)
AI825241	pooled germ cell tumors	.a	729 to 1118	390 to 1				390/390 (100 %)	2 diff (99.5 %id)
AW000792	colon, colonic mucosa from 3 patients with Crohn'sdisease	.a	737 to 1144	410 to 3				408/410 (99 %)	0 diff (100 %id)
AW137573		.a	745 to 1145	401 to 1				401/401 (100 %)	0 diff (100 %id)
F34204	pectoral muscle (after mastectomy)	.a	758 to 927	1 to 169				169/169 (100 %)	2 diff (98.9 %id)
F27540	pectoral muscle (after mastectomy)	.a	808 to 1089	1 to 282				282/282 (100 %)	1 diff (99.7 %id)
AA523549	colon	.a	820 to 1106	293 to 10				284/293 (96 %)	0 diff (100 %id)
TI_57171799		.b	1 to 719	29 to 750	E133D R134T K135E R136E L137A ...	tiling clone,		722/869 (83 %)	14 diff (98.4 %id)
AA688087	germinal center B cell	.b	23 to 156	133 to 1				133/133 (100 %)	1 diff (99.3 %id)
AI298723	carcinoid, lung	.b	30 to 156	127 to 1				127/127 (100 %)	5 diff (96.1 %id)
FN149594	breast carcinoma	.b	54 to 151	1 to 98				98/98 (100 %)	0 diff (100 %id)
BE503611	carcinoid, lung	.c	1 to 461	461 to 1	exact	tiling clone,		461/461 (100 %)	1 diff (99.8 %id)