AceView: Gene:DUOXA1, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView.

Note that this locus is complex: it appears to produce several proteins with no sequence overlap.
Expression: According to AceView, this gene is well expressed, 0.7 times the average gene in this release. The sequence of this gene is defined by 76 GenBank accessions from 65 cDNA clones, some from lung (seen 11 times), head neck (6), trachea (6), primary lung cystic fibrosis epithelialcells (4), prostate (4), tongue (3), tongue, tumor tissue (3) and 26 other tissues. We annotate structural defects or features in 18 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 22 distinct introns (21 gt-ag, 1 gc-ag). Transcription produces 15 different mRNAs, 13 alternatively spliced variants and 2 unspliced forms. There are 3 probable alternative promotors, 3 non overlapping alternative last exons and 4 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 7 cassette exons, overlapping exons with different boundaries, splicing versus retention of 5 introns. 719 bp of this gene are antisense to spliced gene DUOXA2, raising the possibility of regulated alternate expression.
Note that mRNA .hAug10 was found in vivo, although it is a predicted target of nonsense mediated mRNA decay (NMD).
Function: There are 7 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to a disease (Breast Neoplasms) and proposed to participate in a process (protein transport). Proteins are expected to localize in various compartments (membrane, plasma membrane, endoplasmic reticulum membrane, integral to membrane).
Protein coding potential: 11 spliced and the unspliced mRNAs putatively encode good proteins, altogether 12 different isoforms (9 complete, 2 COOH complete, 1 partial), some containing Dual oxidase maturation factor domain [Pfam], some transmembrane domains [Psort2]. The remaining 3 mRNA variants (2 spliced, 1 unspliced; 1 partial) appear not to encode good proteins.
2 isoforms are annotated using as Met a Kozak-compatible non-AUG start, thereby gaining a minimum of 71 amino acids N-terminal to the first AUG.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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cDNA accession Links to the sequence	Tissue most 5' clones in red	Match mRNA	From bp to bp in mRNA	From bp to bp in accs.	Clone encodes complete protein (with AA variation)	Features	Anomalies detected by AceView	Accession match over (% length)	Base differences relative to genome (% identity)
AK027187	Human lung	.h	1 to 1562	10 to 1571	exact	tiling clone, available from FLJ, AAA		1562/2386 (65 %)	4 diff (99.9 %id)
AK056896	Prostate	.g	1 to 2681	4 to 2684	exact	tiling clone, available from FLJ,		2684/2684 (100 %)	0 diff (100 %id)
AK292771	trachea	.b	1 to 1964	2 to 1965		tiling clone,		1965/1965 (100 %)	1 diff (100.0 %id)
BC020841	lung	.d	1 to 1674	3 to 1676	exact	tiling clone, available from MGC, AAA		1676/1676 (100 %)	2 diff (99.9 %id)
BC029819	Brain, Lung, Testis, adult, pooled whole	.a	2 to 1878	1 to 1877	exact	tiling clone, available from MGC, AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	1877/1877 (100 %)	1 diff (100.0 %id)
BE149943	head_neck	.g	857 to 1239	383 to 1			Submitted on the opposite strand	383/395 (96 %)	13 diff (96.8 %id)
BE162052	head_neck	.g	1192 to 1582	418 to 25			Submitted on the opposite strand	394/418 (94 %)	0 diff (100 %id)
BE931808	head_neck	.g	1181 to 1589	406 to 1				406/409 (99 %)	2 diff (99.6 %id)
BF334514	colon	.g	857 to 1191	338 to 1				338/344 (98 %)	17 diff (95.1 %id)
BF350167	head_neck	.g	1292 to 1595	1 to 301				301/315 (95 %)	7 diff (97.8 %id)
BF352476	head_neck	.g	673 to 997	334 to 10				325/334 (97 %)	0 diff (100 %id)
BF843140	head_neck	.g	323 to 622	4 to 301				298/301 (99 %)	6 diff (98.1 %id)
BQ326767	colon_normal	.l-u	1 to 334	83 to 419	P3T P5F G6W P7S I8P ...	tiling clone,		337/419 (80 %)	6 diff (98.6 %id)
DA342985	substantia nigra	.j	1 to 497	4 to 500		tiling clone, capped		499/499 (100 %)	1 diff (99.8 %id)
AJ403116	colon, larynx epithelium	.c	177 to 583	407 to 1		tiling clone,		407/407 (100 %)	3 diff (99.3 %id)
DA437106	tongue, tumor tissue	.n-u	15 to 550	2 to 537	P60L	capped		536/536 (100 %)	1 diff (99.9 %id)
DA442141	tongue, tumor tissue	.f	1 to 577	2 to 578		tiling clone, capped		577/577 (100 %)	1 diff (99.9 %id)
DA459941	tongue, tumor tissue	.n-u	1 to 553	6 to 558	P60L	capped		557/557 (100 %)	1 diff (99.9 %id)
CV030265	mixed	.b	372 to 993	1 to 622				622/622 (100 %)	0 diff (100 %id)
AL709690	human skeletal muscle	.e	1 to 442	1 to 442		tiling clone,	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	442/442 (100 %)	1 diff (99.8 %id)
AL709691	human skeletal muscle	.e	1633 to 2114	501 to 20		tiling clone, AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	482/482 (100 %)	1 diff (99.8 %id)
DQ489735	thyroid gland	.f	354 to 1397	1 to 1044		tiling clone,		1044/1044 (100 %)	0 diff (100 %id)
EU927394		.f	360 to 1391	1 to 1032				1032/1032 (100 %)	0 diff (100 %id)
EU927395		.g	53 to 949	1 to 897	exact			897/897 (100 %)	0 diff (100 %id)
EU927396		.b	372 to 1823	1 to 1452		tiling clone,		1452/1452 (100 %)	0 diff (100 %id)
EU927397		.c	494 to 1810	1 to 1317	exact	tiling clone,		1317/1317 (100 %)	0 diff (100 %id)
DA585782	lung	.n-u	1 to 543	4 to 547	E10G R11E V12G W13M G15R ...	capped		546/546 (100 %)	4 diff (99.3 %id)
W80832	heart	.g	1497 to 1953	459 to 1				459/467 (98 %)	6 diff (98.8 %id)
AA630445	lung	.g	1639 to 1955	315 to 1				315/315 (100 %)	3 diff (99.1 %id)
AA618335	thyroid	.g	1949 to 2248	17 to 315				299/315 (94 %)	6 diff (98.1 %id)
AI572329	mixed (see below), Pooled human melanocyte, fetal heart, andpregnant uterus	.g	1757 to 1953	197 to 1				197/200 (98 %)	0 diff (100 %id)
AI653921	serous papillary carcinoma, high grade, 2pooled tumors, uterus	.g	2320 to 2565	246 to 1				246/246 (100 %)	1 diff (99.6 %id)
AI924216	moderately-differentiated endometrialadenocarcinoma, 3 pooled tumors, uterus	.g	2156 to 2681	539 to 14		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	526/526 (100 %)	4 diff (99.3 %id)
BG536379	lung	.d	1 to 789	4 to 787				787/811 (97 %)	13 diff (98.4 %id)
BI821671	pooled brain, lung, testis	.a	2 to 548	1 to 551				551/1061 (51 %)	9 diff (99.2 %id)
BQ017315	lung, Metastatic Chondrosarcoma	.b	1380 to 1964	602 to 19		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	584/584 (100 %)	3 diff (99.5 %id)
CD511927	Pooled-Skin	.g	2421 to 2681	1 to 261		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	261/261 (100 %)	2 diff (99.3 %id)
TI_57199191		.a	1 to 719	44 to 786		tiling clone,		662/1105 (59 %)	24 diff (97.9 %id)
DA669373	esophagus	.n-u	1 to 463	6 to 469	E10G R11E V12G W13M G15R ...	capped		468/468 (100 %)	2 diff (99.6 %id)
NM_144565.2		.a	2 to 1878	1 to 1877	exact	RefSeq, AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	1877/1877 (100 %)	1 diff (100.0 %id)
DA764633	tongue	.k	1 to 569	4 to 572	exact	tiling clone, capped		571/571 (100 %)	1 diff (99.9 %id)
DA767233	tongue	.n-u	1 to 570	6 to 575	P60L	tiling clone, capped		574/574 (100 %)	1 diff (99.9 %id)
DA767251	tongue	.n-u	1 to 555	4 to 559	E10G R11E V12G W13M G15R ...	capped		558/558 (100 %)	4 diff (99.3 %id)
DA869593	Prostate	.g	1 to 539	4 to 542		capped		541/541 (100 %)	0 diff (100 %id)
DB329840	Prostate	.g	2107 to 2681	576 to 1				576/576 (100 %)	1 diff (99.9 %id)
DA879008	Prostate	.f	25 to 506	2 to 483		capped		482/483 (99 %)	1 diff (99.8 %id)
TI_1948132223		.b	372 to 1056	139 to 829				691/1222 (56 %)	23 diff (98.2 %id)
TI_1948132224		.b	1151 to 1828	789 to 105				685/1360 (50 %)	18 diff (98.7 %id)
TI_1948133152		.b	372 to 1141	131 to 907				777/1120 (69 %)	20 diff (98.3 %id)
TI_1948133153		.b	925 to 1828	1025 to 115				911/1214 (75 %)	35 diff (97.2 %id)
DA968391	stomach	.n-u	1 to 568	2 to 569	P60L	capped		568/568 (100 %)	1 diff (99.9 %id)
DB013985	esophageal, tumor tissue	.m	1 to 577	4 to 580		tiling clone, capped		579/579 (100 %)	1 diff (99.9 %id)
DB015689	esophageal, tumor tissue	.n-u	1 to 448	2 to 449	R92L	tiling clone, capped		448/448 (100 %)	1 diff (99.8 %id)
DB125079	thymus	.b	630 to 1142	2 to 515		capped		514/514 (100 %)	1 diff (99.9 %id)
TI_149290452		.g	1877 to 2681	896 to 100		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	797/797 (100 %)	19 diff (97.7 %id)
TI_149299870		.g	1840 to 2688	925 to 78		tiling clone, AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	848/1002 (84 %)	14 diff (98.7 %id)
TI_149301053		.g	1989 to 2681	774 to 82		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	693/693 (100 %)	1 diff (99.9 %id)
TI_149312082		.i	1 to 808	910 to 107	K155Q D156R P157S D158*	tiling clone, AAA		804/955 (84 %)	12 diff (98.8 %id)
TI_149313496		.g	1789 to 2674	959 to 86		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	874/967 (90 %)	13 diff (98.7 %id)
TI_154036096		.g	1213 to 1983	830 to 73		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	758/917 (82 %)	18 diff (98.1 %id)
DB196136	trachea	.j	1 to 557	6 to 563	S6P	tiling clone, capped		562/562 (100 %)	3 diff (99.5 %id)
DB196564	trachea	.b	1 to 493	2 to 494		capped		493/493 (100 %)	0 diff (100 %id)
DB207808	trachea	.c	1 to 531	2 to 533		tiling clone, capped		532/532 (100 %)	6 diff (98.9 %id)
DB214164	trachea	.o	1 to 455	4 to 459	V105X	tiling clone, capped		458/458 (100 %)	1 diff (99.8 %id)
DB214715	trachea	.o	1 to 466	4 to 470	exact	tiling clone, capped		469/469 (100 %)	2 diff (99.6 %id)
BM973444	lung	.g	2107 to 2681	593 to 19		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	575/575 (100 %)	6 diff (99.0 %id)
CB850544	lung, Primary Lung Cystic Fibrosis EpithelialCells	.g	2020 to 2688	687 to 19		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	669/669 (100 %)	0 diff (100 %id)
BM977010	lung, Primary Lung Cystic Fibrosis EpithelialCells	.g	2010 to 2681	690 to 19		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	672/672 (100 %)	1 diff (99.9 %id)
CB305399	lung, Primary Lung Cystic Fibrosis EpithelialCells	.g	1955 to 2674	737 to 19		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	719/719 (100 %)	2 diff (99.8 %id)
BM977797	lung, Primary Lung Cystic Fibrosis EpithelialCells	.g	297 to 981	705 to 19		AAA		687/687 (100 %)	4 diff (99.5 %id)
CA444325	lung, Metastatic Chondrosarcoma	.g	1275 to 1983	721 to 17		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	705/705 (100 %)	5 diff (99.3 %id)
CA429351	Cell Line, Chondrosarcoma	.g	1368 to 1748	1 to 381			Submitted on the opposite strand	381/387 (98 %)	3 diff (99.3 %id)
DA862636	placenta	.g	2020 to 2688	687 to 19		capped	Suspected internal deletion, suspected internal deletion, this clone was ignored	669/669 (100 %)	0 diff (100 %id)
DB329094	placenta	.g	2010 to 2681	690 to 19			Suspected internal deletion, suspected internal deletion, this clone was ignored	672/672 (100 %)	1 diff (99.9 %id)
DA870157	Prostate	.g	2010 to 2681	690 to 19		capped	This clone was ignored	672/672 (100 %)	1 diff (99.9 %id)
DB329869	Prostate	.g	1955 to 2674	737 to 19			This clone was ignored	719/719 (100 %)	2 diff (99.8 %id)
CB305399	lung, Primary Lung Cystic Fibrosis EpithelialCells	.g	1955 to 2674	737 to 19		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	719/719 (100 %)	2 diff (99.8 %id)
BM977797	lung, Primary Lung Cystic Fibrosis EpithelialCells	.g	297 to 981	705 to 19		AAA		687/687 (100 %)	4 diff (99.5 %id)
BM977797	lung, Primary Lung Cystic Fibrosis EpithelialCells	.g	297 to 981	705 to 19		AAA		687/687 (100 %)	4 diff (99.5 %id)
CA444325	lung, Metastatic Chondrosarcoma	.g	1275 to 1983	721 to 17		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	705/705 (100 %)	5 diff (99.3 %id)
CA444325	lung, Metastatic Chondrosarcoma	.g	1275 to 1983	721 to 17		AAA	Possibly primed on the genome, locally A rich (17/19 A in genome downstream of last aligned base)	705/705 (100 %)	5 diff (99.3 %id)
CA429351	Cell Line, Chondrosarcoma	.g	1368 to 1748	1 to 381			Submitted on the opposite strand	381/387 (98 %)	3 diff (99.3 %id)
CA429351	Cell Line, Chondrosarcoma	.g	1368 to 1748	1 to 381			Submitted on the opposite strand	381/387 (98 %)	3 diff (99.3 %id)