Expression: According to AceView, this gene is moderately expressed, only 32.3% of the average gene in this release. The sequence of this gene is defined by 42 GenBank accessions from 38 cDNA clones, some from pooled, cerebellum, kidney, placenta,testis, lung, colon, liver, heart, thyroid, bladder,uterus, PCR rescued clones (seen 2 times), synovial membrane tissue from rheumatioidarthritis (2), blood, adult leukocytes (once), brain, lung, testis, adult, pooled whole (once), breast carcinoma (once), leukocyte (once), pooled brain, lung, testis (once).
Alternative mRNA variants and regulation: The gene contains 10 distinct gt-ag introns. Transcription produces 8 alternatively spliced mRNAs. There are 4 probable alternative promotors, 2 non overlapping alternative last exons and 3 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 3 cassette exons, overlapping exons with different boundaries.
Function: There are 128 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to diseases (Alzheimer Disease; Asthma; Brain Ischemia; Bronchiolitis, Viral; Chronic Disease; Dermatitis, atopic; Disease Progression; Fibrosis; Hepatitis C and 12 others), proposed to participate in pathways (CCR3 signaling in Eosinophils, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, IL 5 Signaling Pathway, Selective expression of chemokine receptors during T-cell polarization, The Role of Eosinophils in the Chemokine Network of Allergy) and processes (chemotaxis, interspecies interaction between organisms, positive regulation of endothelial cell proliferation). Proteins are expected to have molecular functions (C-C chemokine receptor activity, G-protein coupled receptor activity, protein binding) and to localize in various compartments (membrane, plasma membrane, cytoplasm). Putative protein interactors have been described (CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL15ANDCCL14, CCL24, CCL26, CCL28, CCR3, CXCL9, CXCL10, CXCL11, FGR, HCK).
Protein coding potential: 7 spliced mRNAs putatively encode good proteins, altogether 4 different isoforms (3 complete, 1 partial), some containing domains 7 transmembrane receptor (rhodopsin family), Serpentine type 7TM GPCR chemoreceptor Srsx [Pfam], some transmembrane domains [Psort2]. The remaining mRNA variant (spliced; partial) appears not to encode a good protein.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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