AceView: Gene:CCDC148, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView.

Note that this locus is complex: it appears to produce several proteins with no sequence overlap.
Expression: According to AceView, this gene is well expressed, 0.5 times the average gene in this release. The sequence of this gene is defined by 61 GenBank accessions from 54 cDNA clones, some from brain (seen 9 times), glioblastoma (pooled) (8), amygdala (3), kidney (3), testis (3), whole brain (3), breast carcinoma (2) and 17 other tissues.
Alternative mRNA variants and regulation: The gene contains 18 distinct gt-ag introns. Transcription produces 9 different mRNAs, 7 alternatively spliced variants and 2 unspliced forms. There are 4 non overlapping alternative last exons and 8 validated alternative polyadenylation sites (see the diagram). The mRNAs appear to differ by truncation of the 3' end, presence or absence of 7 cassette exons. 61 bp of this gene are antisense to spliced gene leedo, raising the possibility of regulated alternate expression.
Note that mRNA .eAug10 was found in vivo, although it is a predicted target of nonsense mediated mRNA decay (NMD).
Function: There is one article specifically referring to this gene in PubMed. Proteins are expected to localize in nucleus. No phenotype has yet been reported to our knowledge: this gene's in vivo function is yet unknown.
Protein coding potential: 7 spliced mRNAs putatively encode good proteins, altogether 7 different isoforms (4 complete, 3 COOH complete), some containing a second peroximal domain, a vacuolar domain, a coiled coil stretch [Psort2]. The remaining 2 mRNA variants (2 unspliced) appear not to encode good proteins.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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cDNA accession Links to the sequence	Tissue most 5' clones in red	Match mRNA	From bp to bp in mRNA	From bp to bp in accs.	Clone encodes complete protein (with AA variation)	Features	Anomalies detected by AceView	Accession match over (% length)	Base differences relative to genome (% identity)
AF458588	brain	.a	1 to 1899	287 to 2185	K321R	tiling clone, AAA		1899/2185 (86 %)	1 diff (100.0 %id)
AK058105	testis	.f	1 to 874	200 to 1073	exact	tiling clone, available from FLJ,		874/1073 (81 %)	0 diff (100 %id)
AK123220	amygdala	.d	1 to 1892	184 to 2075	K42R	tiling clone, available from FLJ,		1892/2075 (91 %)	1 diff (100.0 %id)
AK308783	amygdala	.g	1 to 1248	338 to 1585	K183R	tiling clone,		1248/1585 (78 %)	2 diff (99.9 %id)
AK309246	thalamus	.c	1 to 1177	295 to 1471	K280R	tiling clone,		1185/1471 (80 %)	2 diff (99.9 %id)
AK311042	uterus	.c	99 to 1212	328 to 1447		tiling clone,		1126/1447 (77 %)	11 diff (99.3 %id)
BC107596	PCR rescued clones	.b	1 to 1636	151 to 1786	Y161F K183R	tiling clone,		1636/1786 (91 %)	3 diff (99.9 %id)
BC107597	PCR rescued clones	.a	1 to 1892	151 to 2041	K321R R375D L376W E377K M378W ...			1891/2041 (92 %)	2 diff (100.0 %id)
BG459711		.a	1607 to 1891	301 to 17			Submitted on the opposite strand	285/302 (94 %)	0 diff (100 %id)
BG460117		.a	1607 to 1891	288 to 4			Submitted on the opposite strand	285/288 (98 %)	0 diff (100 %id)
BG460399		.a	1607 to 1850	283 to 39			Submitted on the opposite strand	245/253 (96 %)	0 diff (100 %id)
BG460846		.a	1607 to 1882	282 to 7			Submitted on the opposite strand	276/282 (97 %)	0 diff (100 %id)
BG461289		.a	1607 to 1892	307 to 22			Submitted on the opposite strand	286/307 (93 %)	0 diff (100 %id)
BG461576		.a	1607 to 1892	301 to 16			Submitted on the opposite strand	286/301 (95 %)	0 diff (100 %id)
BG461933		.a	1607 to 1900	309 to 14			Submitted on the opposite strand	296/309 (95 %)	0 diff (100 %id)
DA168499	amygdala	.d	1 to 394	184 to 577		capped		394/576 (68 %)	1 diff (99.9 %id)
DB302506	amygdala	.d	1347 to 1892	546 to 1				546/546 (100 %)	0 diff (100 %id)
DA387770	thalamus	.g	877 to 1445	2 to 570		tiling clone, capped		569/569 (100 %)	2 diff (99.7 %id)
DB311703	thalamus	.g	2121 to 2675	555 to 1		tiling clone,		555/555 (100 %)	0 diff (100 %id)
BX117492	whole brain	.i-u	1 to 508	522 to 15	exact	tiling clone, AAA		508/508 (100 %)	0 diff (100 %id)
CV029749	mixed	.a	1 to 615	24 to 635				612/653 (93 %)	7 diff (99.0 %id)
FN122870	breast carcinoma	.a	370 to 451	81 to 1			Submitted on the opposite strand	81/81 (100 %)	1 diff (98.8 %id)
FN157869	breast carcinoma	.a	640 to 740	100 to 1			Submitted on the opposite strand	100/100 (100 %)	3 diff (97.0 %id)
DB525806	testis	.f	443 to 874	1 to 432			Submitted on the opposite strand	432/433 (99 %)	2 diff (99.6 %id)
AI359353	brain, glioblastoma (pooled)	.a	1447 to 1891	445 to 1				445/445 (100 %)	0 diff (100 %id)
AI424612	brain, glioblastoma (pooled)	.a	1680 to 1891	212 to 1				212/212 (100 %)	0 diff (100 %id)
AI690408	serous papillary carcinoma, high grade, 2pooled tumors, uterus	.i-u	24 to 257	234 to 1	exact			234/234 (100 %)	0 diff (100 %id)
AI634798	Kidney	.a	1621 to 2098	509 to 32				478/509 (93 %)	0 diff (100 %id)
AI650321	Kidney	.a	1602 to 2065	478 to 15		AAA		464/464 (100 %)	0 diff (100 %id)
AW055164	brain, glioblastoma (pooled)	.a	1445 to 1891	448 to 1				448/448 (100 %)	24 diff (94.7 %id)
AW188468	colon, moderately differentiated adenocarcinoma	.a	691 to 1221	531 to 1				531/531 (100 %)	2 diff (99.7 %id)
AW615222	Kidney	.a	1442 to 1892	451 to 1				451/451 (100 %)	0 diff (100 %id)
BF593824	brain, glioblastoma (pooled)	.a	1375 to 1891	517 to 1				517/517 (100 %)	0 diff (100 %id)
BE856330	brain, glioblastoma (pooled)	.a	1406 to 1891	486 to 1				486/486 (100 %)	2 diff (99.6 %id)
BF940091	brain, glioblastoma (pooled)	.a	1377 to 1891	515 to 1				515/515 (100 %)	0 diff (100 %id)
BF940211	brain, glioblastoma (pooled)	.a	1314 to 1891	578 to 1				578/578 (100 %)	0 diff (100 %id)
BF111993	pooled	.a	1406 to 1900	498 to 4				495/498 (99 %)	0 diff (100 %id)
BF594137	brain, glioblastoma (pooled)	.a	1399 to 1891	493 to 1				493/493 (100 %)	1 diff (99.8 %id)
BC015395	Prostate, adenocarcinoma.	.f	1 to 874	287 to 1160	M149V	tiling clone, available from MGC, AAA		874/1160 (75 %)	2 diff (99.9 %id)
BG179320	adenocarcinoma, cell line, Prostate	.a	1 to 438	286 to 715		available from MGC,		430/956 (44 %)	12 diff (98.8 %id)
BG291599	bladder, transitional cell papilloma, cell line	.a	649 to 1219	1 to 571		AAA		571/571 (100 %)	2 diff (99.7 %id)
BC031994	Skin, squamous cell carcinoma	.a	758 to 1892	1 to 1136		available from MGC, AAA		1136/1136 (100 %)	2 diff (99.9 %id)
BG678084	skin, squamous cell carcinoma	.a	758 to 1616	1 to 863		available from MGC,		865/863 (100 %)	35 diff (96.0 %id)
BG743417	skin	.a	704 to 1467	1 to 778				780/844 (92 %)	21 diff (97.6 %id)
BC105928	PCR rescued clones	.e	1 to 1794	151 to 1942	K183R K271S A272F L273G E274I ...	tiling clone,		1792/1942 (92 %)	4 diff (99.8 %id)
EB386556	eye, optic nerve	.h-u	1 to 838	1 to 838	exact	tiling clone,		838/838 (100 %)	1 diff (99.9 %id)
NM_138803.3		.a	1 to 2509	338 to 2846	exact	RefSeq,		2509/2846 (88 %)	0 diff (100 %id)
NM_001171637.1		.c	99 to 1212	328 to 1447		RefSeq,		1126/1447 (77 %)	9 diff (99.4 %id)
TI_1948101547		.a	1 to 726	150 to 878		fully sequenced,		729/878 (83 %)	17 diff (98.1 %id)
TI_1948101548		.a	198 to 744	609 to 62		fully sequenced,		548/609 (89 %)	1 diff (99.9 %id)
TI_1948101714		.a	1 to 748	150 to 900		fully sequenced,		751/900 (83 %)	16 diff (98.3 %id)
TI_1948101715		.a	433 to 744	371 to 60		fully sequenced,		312/371 (84 %)	1 diff (99.8 %id)
TI_1948101882		.a	1 to 155	158 to 312		fully sequenced,		155/207 (74 %)	0 diff (100 %id)
TI_1948101883		.a	94 to 744	774 to 123		fully sequenced,		652/774 (84 %)	2 diff (99.8 %id)
TI_1948102050		.a	1 to 748	158 to 910		fully sequenced,		753/880 (85 %)	17 diff (98.1 %id)
TI_1948102051		.a	198 to 744	671 to 124		fully sequenced,		548/671 (81 %)	1 diff (99.9 %id)
BP369440	testis	.a	1 to 374	200 to 573				374/573 (65 %)	0 diff (100 %id)
T08245		.e	1 to 1794	151 to 1942		tiling clone,		1792/1942 (92 %)	4 diff (99.8 %id)
T78764	whole brain	.h-u	1 to 838	1 to 838		tiling clone,		838/838 (100 %)	1 diff (99.9 %id)
H11986	whole brain	.h-u	1 to 838	1 to 838		tiling clone,		838/838 (100 %)	1 diff (99.9 %id)
H11987	whole brain	.a	1 to 2509	338 to 2846		RefSeq,		2509/2846 (88 %)	0 diff (100 %id)
NM_001171637.1		.c	99 to 1212	328 to 1447		RefSeq,		1126/1447 (77 %)	9 diff (99.4 %id)
TI_1948101547		.a	1 to 726	150 to 878		fully sequenced,		729/878 (83 %)	17 diff (98.1 %id)
TI_1948101548		.a	198 to 744	609 to 62		fully sequenced,		548/609 (89 %)	1 diff (99.9 %id)
TI_1948101714		.a	1 to 748	150 to 900		fully sequenced,		751/900 (83 %)	16 diff (98.3 %id)
TI_1948101715		.a	433 to 744	371 to 60		fully sequenced,		312/371 (84 %)	1 diff (99.8 %id)
TI_1948101882		.a	1 to 155	158 to 312		fully sequenced,		155/207 (74 %)	0 diff (100 %id)
TI_1948101883		.a	94 to 744	774 to 123		fully sequenced,		652/774 (84 %)	2 diff (99.8 %id)
TI_1948102050		.a	1 to 748	158 to 910		fully sequenced,		753/880 (85 %)	17 diff (98.1 %id)
TI_1948102051		.a	198 to 744	671 to 124		fully sequenced,		548/671 (81 %)	1 diff (99.9 %id)
BP369440	testis	.a	1 to 374	200 to 573				374/573 (65 %)	0 diff (100 %id)