Note that this locus is complex: it appears to produce several proteins with no sequence overlap.
Expression: According to AceView, this gene is
well expressed , 0.7 times the average gene in this release. The
sequence of this gene is defined by
79 GenBank accessions from 73 cDNA clones, some from brain (seen 3 times), hypothalamus (3), liver and spleen (3), lung and heart, PCR rescued clones (3), testis (3), amygdala (2), colon (2) and 20 other tissues. We annotate
structural defects or features in 7 cDNA clones.
Alternative mRNA variants and regulation: The gene contains
33 distinct gt-ag introns . Transcription produces
12 different mRNAs , 11 alternatively spliced variants and 1 unspliced form. There are 5 probable
alternative promotors , 5 non overlapping alternative last exons and 6 validated
alternative polyadenylation sites (see the
diagram ). The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 6
cassette exons , overlapping exons with different boundaries. 237 bp of this gene
are antisense to spliced gene sobloy , raising the possibility of regulated alternate expression.
Efficacy of translation may be reduced by the presence of a shorter translated product (
uORF ) initiating at an AUG upstream of the main open reading frame (in variant dAug10, fAug10, gAug10).
Function: There are
12 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to
diseases (Atherosclerosis; Myocardial Infarction) and proposed to participate in a
process (microtubule-based movement). Proteins are expected to have molecular
functions (protein binding, ATP binding, microtubule motor activity, nucleotide binding) and to
localize in various compartments (nucleus, male germ cell nucleus, microtubule). A putative
protein interactor has been described (APPBP2).
Protein coding potential: 11 spliced mRNAs putatively encode
good proteins , altogether
11 different isoforms (7 complete, 3 COOH complete, 1 partial ), some containing Kinesin motor domain
[Pfam] , a coiled coil stretch
[Psort2] . The remaining mRNA variant (unspliced) appears not to encode a good protein.
Isoform KIF6.dAug10 is annotated using as Met a
Kozak-compatible g..CTGg start, thereby gaining 125 amino acids N-terminal to the first AUG. Finally proteins from this gene may be modulated by
acetylation; phosphorylation , as detailed at PhosphoSite.
Please quote:
AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12
Gene KIF6
5'
3'
encoded on minus strand of chromosome 6 from 39,693,180 to 39,302,876
669
544
278
393
354
419
431
283
301
401
437
417
453
1316
1415
1659
1443
1978
1261
1432
2557
1209
a
[NM]
669
544
278
393
354
419
431
283
301
401
437
417
453
1316
13
1443
1978
1261
1432
2557
1209
b
669
544
278
393
354
419
431
283
301
401
437
18
1316
1415
1659
1443
1978
1261
1432
2557
1209
c
669
8
8
278
393
354
419
431
283
301
401
437
417
453
1316
1415
1659
1443
1978
808
2557
1209
d
7
393
31
431
283
301
401
437
e
1316
1415
1659
1443
1978
1261
1432
2557
98
f
669
544
358
i
431
283
3
h
1316
1415
1659
1443
1978
1261
1432
2557
1209
g
48
358
k
401
437
417
j
l-u
5kb
0
160 bp exon
160 bp exon
4433 bp [gt-ag] intron
17 GenBank accessions
652 RNA-seq supporting reads
101 UHR pooled cells
222 Brain
4 Blood
313 Neuroblastoma
12 Other
(also 471 Primates bodymap)
110 bp exon
5935 bp [gt-ag] intron
15 GenBank accessions
529 RNA-seq supporting reads
94 UHR pooled cells
152 Brain
7 Blood
260 Neuroblastoma
16 Other
(also 438 Primates bodymap)
75 bp exon
74934 bp [gt-ag] intron
16 GenBank accessions
262 RNA-seq supporting reads
17 UHR pooled cells
108 Brain
2 Blood
124 Neuroblastoma
11 Other
(also 379 Primates bodymap)
148 bp exon
4651 bp [gt-ag] intron
19 GenBank accessions
374 RNA-seq supporting reads
25 UHR pooled cells
137 Brain
2 Blood
200 Neuroblastoma
10 Other
(also 587 Primates bodymap)
110 bp exon
21530 bp [gt-ag] intron
17 GenBank accessions
337 RNA-seq supporting reads
22 UHR pooled cells
142 Brain
3 Blood
157 Neuroblastoma
13 Other
(also 431 Primates bodymap)
130 bp exon
16928 bp [gt-ag] intron
17 GenBank accessions
402 RNA-seq supporting reads
18 UHR pooled cells
176 Brain
2 Blood
177 Neuroblastoma
29 Other
(also 958 Primates bodymap)
207 bp exon
9649 bp [gt-ag] intron
22 GenBank accessions
409 RNA-seq supporting reads
22 UHR pooled cells
168 Brain
1 Blood
204 Neuroblastoma
14 Other
(also 843 Primates bodymap)
144 bp exon
1276 bp [gt-ag] intron
24 GenBank accessions
259 RNA-seq supporting reads
2 UHR pooled cells
106 Brain
2 Blood
121 Neuroblastoma
28 Other
(also 601 Primates bodymap)
87 bp exon
6738 bp [gt-ag] intron
18 GenBank accessions
283 RNA-seq supporting reads
7 UHR pooled cells
91 Brain
4 Blood
147 Neuroblastoma
34 Other
(also 353 Primates bodymap)
104 bp exon
32367 bp [gt-ag] intron
18 GenBank accessions
383 RNA-seq supporting reads
24 UHR pooled cells
162 Brain
4 Blood
171 Neuroblastoma
22 Other
(also 640 Primates bodymap)
106 bp exon
889 bp [gt-ag] intron
21 GenBank accessions
416 RNA-seq supporting reads
13 UHR pooled cells
171 Brain
3 Blood
192 Neuroblastoma
37 Other
(also 599 Primates bodymap)
139 bp exon
4333 bp [gt-ag] intron
13 GenBank accessions
404 RNA-seq supporting reads
24 UHR pooled cells
167 Brain
2 Blood
191 Neuroblastoma
20 Other
(also 600 Primates bodymap)
219 bp exon
108841 bp [gt-ag] intron
9 GenBank accessions
444 RNA-seq supporting reads
22 UHR pooled cells
197 Brain
1 Blood
199 Neuroblastoma
25 Other
(also 419 Primates bodymap)
109 bp exon
11049 bp [gt-ag] intron
27 GenBank accessions
1289 RNA-seq supporting reads
377 UHR pooled cells
546 Brain
3 Blood
336 Neuroblastoma
27 Other
(also 718 Primates bodymap)
56 bp exon
34275 bp [gt-ag] intron
23 GenBank accessions
1392 RNA-seq supporting reads
427 UHR pooled cells
604 Brain
2 Blood
343 Neuroblastoma
16 Other
(also 537 Primates bodymap)
51 bp exon
23103 bp [gt-ag] intron
24 GenBank accessions
1635 RNA-seq supporting reads
494 UHR pooled cells
701 Brain
4 Blood
414 Neuroblastoma
22 Other
(also 419 Primates bodymap)
85 bp exon
1903 bp [gt-ag] intron
28 GenBank accessions
1415 RNA-seq supporting reads
469 UHR pooled cells
556 Brain
363 Neuroblastoma
27 Other
(also 375 Primates bodymap)
136 bp exon
3020 bp [gt-ag] intron
26 GenBank accessions
1952 RNA-seq supporting reads
617 UHR pooled cells
832 Brain
478 Neuroblastoma
25 Other
(also 437 Primates bodymap)
98 bp exon
10750 bp [gt-ag] intron
28 GenBank accessions
1233 RNA-seq supporting reads
462 UHR pooled cells
439 Brain
314 Neuroblastoma
18 Other
(also 124 Primates bodymap)
51 bp exon
686 bp [gt-ag] intron
29 GenBank accessions
1403 RNA-seq supporting reads
543 UHR pooled cells
495 Brain
346 Neuroblastoma
19 Other
(also 114 Primates bodymap)
90 bp exon
1884 bp [gt-ag] intron
28 GenBank accessions
2529 RNA-seq supporting reads
762 UHR pooled cells
1116 Brain
631 Neuroblastoma
20 Other
(also 271 Primates bodymap)
107 bp exon
7160 bp [gt-ag] intron
23 GenBank accessions
1186 RNA-seq supporting reads
124 UHR pooled cells
651 Brain
383 Neuroblastoma
28 Other
(also 265 Primates bodymap)
1449 bp exon
38 accessions, NM_145027.4
some from colon (seen 2 times)
testis (2), brain (once)
eye (once), glioblastoma (pooled) (once)
capped 5' end, 2 accessions
Validated 3' end, 2 accessions
1449 bp exon
91 bp exon
91 bp exon
4433 bp [gt-ag] intron
17 GenBank accessions
652 RNA-seq supporting reads
101 UHR pooled cells
222 Brain
4 Blood
313 Neuroblastoma
12 Other
(also 471 Primates bodymap)
110 bp exon
5935 bp [gt-ag] intron
15 GenBank accessions
529 RNA-seq supporting reads
94 UHR pooled cells
152 Brain
7 Blood
260 Neuroblastoma
16 Other
(also 438 Primates bodymap)
75 bp exon
74934 bp [gt-ag] intron
16 GenBank accessions
262 RNA-seq supporting reads
17 UHR pooled cells
108 Brain
2 Blood
124 Neuroblastoma
11 Other
(also 379 Primates bodymap)
148 bp exon
4651 bp [gt-ag] intron
19 GenBank accessions
374 RNA-seq supporting reads
25 UHR pooled cells
137 Brain
2 Blood
200 Neuroblastoma
10 Other
(also 587 Primates bodymap)
110 bp exon
21530 bp [gt-ag] intron
17 GenBank accessions
337 RNA-seq supporting reads
22 UHR pooled cells
142 Brain
3 Blood
157 Neuroblastoma
13 Other
(also 431 Primates bodymap)
130 bp exon
16928 bp [gt-ag] intron
17 GenBank accessions
402 RNA-seq supporting reads
18 UHR pooled cells
176 Brain
2 Blood
177 Neuroblastoma
29 Other
(also 958 Primates bodymap)
207 bp exon
9649 bp [gt-ag] intron
22 GenBank accessions
409 RNA-seq supporting reads
22 UHR pooled cells
168 Brain
1 Blood
204 Neuroblastoma
14 Other
(also 843 Primates bodymap)
144 bp exon
1276 bp [gt-ag] intron
24 GenBank accessions
259 RNA-seq supporting reads
2 UHR pooled cells
106 Brain
2 Blood
121 Neuroblastoma
28 Other
(also 601 Primates bodymap)
87 bp exon
6738 bp [gt-ag] intron
18 GenBank accessions
283 RNA-seq supporting reads
7 UHR pooled cells
91 Brain
4 Blood
147 Neuroblastoma
34 Other
(also 353 Primates bodymap)
104 bp exon
32367 bp [gt-ag] intron
18 GenBank accessions
383 RNA-seq supporting reads
24 UHR pooled cells
162 Brain
4 Blood
171 Neuroblastoma
22 Other
(also 640 Primates bodymap)
106 bp exon
889 bp [gt-ag] intron
21 GenBank accessions
416 RNA-seq supporting reads
13 UHR pooled cells
171 Brain
3 Blood
192 Neuroblastoma
37 Other
(also 599 Primates bodymap)
139 bp exon
4333 bp [gt-ag] intron
13 GenBank accessions
404 RNA-seq supporting reads
24 UHR pooled cells
167 Brain
2 Blood
191 Neuroblastoma
20 Other
(also 600 Primates bodymap)
219 bp exon
108841 bp [gt-ag] intron
9 GenBank accessions
444 RNA-seq supporting reads
22 UHR pooled cells
197 Brain
1 Blood
199 Neuroblastoma
25 Other
(also 419 Primates bodymap)
109 bp exon
11049 bp [gt-ag] intron
27 GenBank accessions
1289 RNA-seq supporting reads
377 UHR pooled cells
546 Brain
3 Blood
336 Neuroblastoma
27 Other
(also 718 Primates bodymap)
56 bp exon
57429 bp [gt-ag] intron
5 GenBank accessions
8 RNA-seq supporting reads
3 UHR pooled cells
2 Brain
3 Neuroblastoma
(also 6 Primates bodymap)
85 bp exon
1903 bp [gt-ag] intron
28 GenBank accessions
1415 RNA-seq supporting reads
469 UHR pooled cells
556 Brain
363 Neuroblastoma
27 Other
(also 375 Primates bodymap)
136 bp exon
3020 bp [gt-ag] intron
26 GenBank accessions
1952 RNA-seq supporting reads
617 UHR pooled cells
832 Brain
478 Neuroblastoma
25 Other
(also 437 Primates bodymap)
98 bp exon
10750 bp [gt-ag] intron
28 GenBank accessions
1233 RNA-seq supporting reads
462 UHR pooled cells
439 Brain
314 Neuroblastoma
18 Other
(also 124 Primates bodymap)
51 bp exon
686 bp [gt-ag] intron
29 GenBank accessions
1403 RNA-seq supporting reads
543 UHR pooled cells
495 Brain
346 Neuroblastoma
19 Other
(also 114 Primates bodymap)
90 bp exon
1884 bp [gt-ag] intron
28 GenBank accessions
2529 RNA-seq supporting reads
762 UHR pooled cells
1116 Brain
631 Neuroblastoma
20 Other
(also 271 Primates bodymap)
107 bp exon
7160 bp [gt-ag] intron
23 GenBank accessions
1186 RNA-seq supporting reads
124 UHR pooled cells
651 Brain
383 Neuroblastoma
28 Other
(also 265 Primates bodymap)
86 bp exon
5 accessions, some from lung and heart
PCR rescued clones (seen once)
Validated 3' end, 1 accession
86 bp exon
91 bp exon
91 bp exon
4433 bp [gt-ag] intron
17 GenBank accessions
652 RNA-seq supporting reads
101 UHR pooled cells
222 Brain
4 Blood
313 Neuroblastoma
12 Other
(also 471 Primates bodymap)
110 bp exon
5935 bp [gt-ag] intron
15 GenBank accessions
529 RNA-seq supporting reads
94 UHR pooled cells
152 Brain
7 Blood
260 Neuroblastoma
16 Other
(also 438 Primates bodymap)
75 bp exon
74934 bp [gt-ag] intron
16 GenBank accessions
262 RNA-seq supporting reads
17 UHR pooled cells
108 Brain
2 Blood
124 Neuroblastoma
11 Other
(also 379 Primates bodymap)
148 bp exon
4651 bp [gt-ag] intron
19 GenBank accessions
374 RNA-seq supporting reads
25 UHR pooled cells
137 Brain
2 Blood
200 Neuroblastoma
10 Other
(also 587 Primates bodymap)
110 bp exon
21530 bp [gt-ag] intron
17 GenBank accessions
337 RNA-seq supporting reads
22 UHR pooled cells
142 Brain
3 Blood
157 Neuroblastoma
13 Other
(also 431 Primates bodymap)
130 bp exon
16928 bp [gt-ag] intron
17 GenBank accessions
402 RNA-seq supporting reads
18 UHR pooled cells
176 Brain
2 Blood
177 Neuroblastoma
29 Other
(also 958 Primates bodymap)
207 bp exon
9649 bp [gt-ag] intron
22 GenBank accessions
409 RNA-seq supporting reads
22 UHR pooled cells
168 Brain
1 Blood
204 Neuroblastoma
14 Other
(also 843 Primates bodymap)
144 bp exon
1276 bp [gt-ag] intron
24 GenBank accessions
259 RNA-seq supporting reads
2 UHR pooled cells
106 Brain
2 Blood
121 Neuroblastoma
28 Other
(also 601 Primates bodymap)
87 bp exon
6738 bp [gt-ag] intron
18 GenBank accessions
283 RNA-seq supporting reads
7 UHR pooled cells
91 Brain
4 Blood
147 Neuroblastoma
34 Other
(also 353 Primates bodymap)
104 bp exon
32367 bp [gt-ag] intron
18 GenBank accessions
383 RNA-seq supporting reads
24 UHR pooled cells
162 Brain
4 Blood
171 Neuroblastoma
22 Other
(also 640 Primates bodymap)
106 bp exon
889 bp [gt-ag] intron
21 GenBank accessions
416 RNA-seq supporting reads
13 UHR pooled cells
171 Brain
3 Blood
192 Neuroblastoma
37 Other
(also 599 Primates bodymap)
190 bp exon
113342 bp [gt-ag] intron
5 GenBank accessions
13 RNA-seq supporting reads
12 Brain
1 Neuroblastoma
109 bp exon
11049 bp [gt-ag] intron
27 GenBank accessions
1289 RNA-seq supporting reads
377 UHR pooled cells
546 Brain
3 Blood
336 Neuroblastoma
27 Other
(also 718 Primates bodymap)
56 bp exon
34275 bp [gt-ag] intron
23 GenBank accessions
1392 RNA-seq supporting reads
427 UHR pooled cells
604 Brain
2 Blood
343 Neuroblastoma
16 Other
(also 537 Primates bodymap)
51 bp exon
23103 bp [gt-ag] intron
24 GenBank accessions
1635 RNA-seq supporting reads
494 UHR pooled cells
701 Brain
4 Blood
414 Neuroblastoma
22 Other
(also 419 Primates bodymap)
85 bp exon
1903 bp [gt-ag] intron
28 GenBank accessions
1415 RNA-seq supporting reads
469 UHR pooled cells
556 Brain
363 Neuroblastoma
27 Other
(also 375 Primates bodymap)
136 bp exon
3020 bp [gt-ag] intron
26 GenBank accessions
1952 RNA-seq supporting reads
617 UHR pooled cells
832 Brain
478 Neuroblastoma
25 Other
(also 437 Primates bodymap)
98 bp exon
10750 bp [gt-ag] intron
28 GenBank accessions
1233 RNA-seq supporting reads
462 UHR pooled cells
439 Brain
314 Neuroblastoma
18 Other
(also 124 Primates bodymap)
51 bp exon
686 bp [gt-ag] intron
29 GenBank accessions
1403 RNA-seq supporting reads
543 UHR pooled cells
495 Brain
346 Neuroblastoma
19 Other
(also 114 Primates bodymap)
90 bp exon
1884 bp [gt-ag] intron
28 GenBank accessions
2529 RNA-seq supporting reads
762 UHR pooled cells
1116 Brain
631 Neuroblastoma
20 Other
(also 271 Primates bodymap)
107 bp exon
7160 bp [gt-ag] intron
23 GenBank accessions
1186 RNA-seq supporting reads
124 UHR pooled cells
651 Brain
383 Neuroblastoma
28 Other
(also 265 Primates bodymap)
86 bp exon
7 accessions, some from lung and heart
PCR rescued clones (seen 2 times)
Validated 3' end, 2 accessions
86 bp exon
160 bp exon
160 bp exon
213 bp uORF
4433 bp [gt-ag] intron
17 GenBank accessions
652 RNA-seq supporting reads
101 UHR pooled cells
222 Brain
4 Blood
313 Neuroblastoma
12 Other
(also 471 Primates bodymap)
110 bp exon
213 bp uORF
2124 bp [gt-ag] intron
1 GenBank accession
7 RNA-seq supporting reads
4 Brain
3 Neuroblastoma
(also 1 Primates bodymap)
213 bp uORF
156 bp exon
156 bp exon
3655 bp [gt-ag] intron
1 GenBank accession
7 RNA-seq supporting reads
5 Brain
2 Neuroblastoma
75 bp exon
75 bp exon
74934 bp [gt-ag] intron
16 GenBank accessions
262 RNA-seq supporting reads
17 UHR pooled cells
108 Brain
2 Blood
124 Neuroblastoma
11 Other
(also 379 Primates bodymap)
148 bp exon
148 bp exon
148 bp exon
4651 bp [gt-ag] intron
19 GenBank accessions
374 RNA-seq supporting reads
25 UHR pooled cells
137 Brain
2 Blood
200 Neuroblastoma
10 Other
(also 587 Primates bodymap)
110 bp exon
110 bp exon
21530 bp [gt-ag] intron
17 GenBank accessions
337 RNA-seq supporting reads
22 UHR pooled cells
142 Brain
3 Blood
157 Neuroblastoma
13 Other
(also 431 Primates bodymap)
130 bp exon
130 bp exon
16928 bp [gt-ag] intron
17 GenBank accessions
402 RNA-seq supporting reads
18 UHR pooled cells
176 Brain
2 Blood
177 Neuroblastoma
29 Other
(also 958 Primates bodymap)
207 bp exon
207 bp exon
9649 bp [gt-ag] intron
22 GenBank accessions
409 RNA-seq supporting reads
22 UHR pooled cells
168 Brain
1 Blood
204 Neuroblastoma
14 Other
(also 843 Primates bodymap)
144 bp exon
144 bp exon
1276 bp [gt-ag] intron
24 GenBank accessions
259 RNA-seq supporting reads
2 UHR pooled cells
106 Brain
2 Blood
121 Neuroblastoma
28 Other
(also 601 Primates bodymap)
87 bp exon
87 bp exon
6738 bp [gt-ag] intron
18 GenBank accessions
283 RNA-seq supporting reads
7 UHR pooled cells
91 Brain
4 Blood
147 Neuroblastoma
34 Other
(also 353 Primates bodymap)
104 bp exon
104 bp exon
32367 bp [gt-ag] intron
18 GenBank accessions
383 RNA-seq supporting reads
24 UHR pooled cells
162 Brain
4 Blood
171 Neuroblastoma
22 Other
(also 640 Primates bodymap)
106 bp exon
106 bp exon
889 bp [gt-ag] intron
21 GenBank accessions
416 RNA-seq supporting reads
13 UHR pooled cells
171 Brain
3 Blood
192 Neuroblastoma
37 Other
(also 599 Primates bodymap)
139 bp exon
139 bp exon
4333 bp [gt-ag] intron
13 GenBank accessions
404 RNA-seq supporting reads
24 UHR pooled cells
167 Brain
2 Blood
191 Neuroblastoma
20 Other
(also 600 Primates bodymap)
219 bp exon
219 bp exon
108841 bp [gt-ag] intron
9 GenBank accessions
444 RNA-seq supporting reads
22 UHR pooled cells
197 Brain
1 Blood
199 Neuroblastoma
25 Other
(also 419 Primates bodymap)
109 bp exon
109 bp exon
11049 bp [gt-ag] intron
27 GenBank accessions
1289 RNA-seq supporting reads
377 UHR pooled cells
546 Brain
3 Blood
336 Neuroblastoma
27 Other
(also 718 Primates bodymap)
56 bp exon
56 bp exon
34275 bp [gt-ag] intron
23 GenBank accessions
1392 RNA-seq supporting reads
427 UHR pooled cells
604 Brain
2 Blood
343 Neuroblastoma
16 Other
(also 537 Primates bodymap)
51 bp exon
51 bp exon
23103 bp [gt-ag] intron
24 GenBank accessions
1635 RNA-seq supporting reads
494 UHR pooled cells
701 Brain
4 Blood
414 Neuroblastoma
22 Other
(also 419 Primates bodymap)
85 bp exon
85 bp exon
1903 bp [gt-ag] intron
28 GenBank accessions
1415 RNA-seq supporting reads
469 UHR pooled cells
556 Brain
363 Neuroblastoma
27 Other
(also 375 Primates bodymap)
136 bp exon
136 bp exon
3020 bp [gt-ag] intron
26 GenBank accessions
1952 RNA-seq supporting reads
617 UHR pooled cells
832 Brain
478 Neuroblastoma
25 Other
(also 437 Primates bodymap)
98 bp exon
98 bp exon
11487 bp [gt-ag] intron
1 GenBank accession
807 RNA-seq supporting reads
161 UHR pooled cells
436 Brain
207 Neuroblastoma
3 Other
(also 217 Primates bodymap)
90 bp exon
90 bp exon
1884 bp [gt-ag] intron
28 GenBank accessions
2529 RNA-seq supporting reads
762 UHR pooled cells
1116 Brain
631 Neuroblastoma
20 Other
(also 271 Primates bodymap)
107 bp exon
107 bp exon
7160 bp [gt-ag] intron
23 GenBank accessions
1186 RNA-seq supporting reads
124 UHR pooled cells
651 Brain
383 Neuroblastoma
28 Other
(also 265 Primates bodymap)
398 bp exon
398 bp exon
2 accessions, some from liver (seen once)
normal nasopharynx (once)
Validated 3' end, 1 accession
398 bp exon
82 bp exon
34647 bp [gt-ag] intron
1 GenBank accession
6 RNA-seq supporting reads
5 Neuroblastoma
1 Other
148 bp exon
4651 bp [gt-ag] intron
19 GenBank accessions
374 RNA-seq supporting reads
25 UHR pooled cells
137 Brain
2 Blood
200 Neuroblastoma
10 Other
(also 587 Primates bodymap)
110 bp exon
38588 bp [gt-ag] intron
1 GenBank accession
30 RNA-seq supporting reads
5 UHR pooled cells
9 Brain
15 Neuroblastoma
1 Other
(also 51 Primates bodymap)
207 bp exon
207 bp exon
9649 bp [gt-ag] intron
22 GenBank accessions
409 RNA-seq supporting reads
22 UHR pooled cells
168 Brain
1 Blood
204 Neuroblastoma
14 Other
(also 843 Primates bodymap)
144 bp exon
1276 bp [gt-ag] intron
24 GenBank accessions
259 RNA-seq supporting reads
2 UHR pooled cells
106 Brain
2 Blood
121 Neuroblastoma
28 Other
(also 601 Primates bodymap)
87 bp exon
6738 bp [gt-ag] intron
18 GenBank accessions
283 RNA-seq supporting reads
7 UHR pooled cells
91 Brain
4 Blood
147 Neuroblastoma
34 Other
(also 353 Primates bodymap)
104 bp exon
32367 bp [gt-ag] intron
18 GenBank accessions
383 RNA-seq supporting reads
24 UHR pooled cells
162 Brain
4 Blood
171 Neuroblastoma
22 Other
(also 640 Primates bodymap)
106 bp exon
889 bp [gt-ag] intron
21 GenBank accessions
416 RNA-seq supporting reads
13 UHR pooled cells
171 Brain
3 Blood
192 Neuroblastoma
37 Other
(also 599 Primates bodymap)
455 bp exon
2 accessions, some from liver and spleen (seen 2 times)
455 bp exon
281 bp exon
281 bp exon
21 bp uORF
281 bp exon
281 bp exon
11049 bp [gt-ag] intron
27 GenBank accessions
1289 RNA-seq supporting reads
377 UHR pooled cells
546 Brain
3 Blood
336 Neuroblastoma
27 Other
(also 718 Primates bodymap)
56 bp exon
56 bp exon
34275 bp [gt-ag] intron
23 GenBank accessions
1392 RNA-seq supporting reads
427 UHR pooled cells
604 Brain
2 Blood
343 Neuroblastoma
16 Other
(also 537 Primates bodymap)
51 bp exon
51 bp exon
23103 bp [gt-ag] intron
24 GenBank accessions
1635 RNA-seq supporting reads
494 UHR pooled cells
701 Brain
4 Blood
414 Neuroblastoma
22 Other
(also 419 Primates bodymap)
85 bp exon
85 bp exon
1903 bp [gt-ag] intron
28 GenBank accessions
1415 RNA-seq supporting reads
469 UHR pooled cells
556 Brain
363 Neuroblastoma
27 Other
(also 375 Primates bodymap)
136 bp exon
136 bp exon
3020 bp [gt-ag] intron
26 GenBank accessions
1952 RNA-seq supporting reads
617 UHR pooled cells
832 Brain
478 Neuroblastoma
25 Other
(also 437 Primates bodymap)
98 bp exon
98 bp exon
10750 bp [gt-ag] intron
28 GenBank accessions
1233 RNA-seq supporting reads
462 UHR pooled cells
439 Brain
314 Neuroblastoma
18 Other
(also 124 Primates bodymap)
51 bp exon
51 bp exon
686 bp [gt-ag] intron
29 GenBank accessions
1403 RNA-seq supporting reads
543 UHR pooled cells
495 Brain
346 Neuroblastoma
19 Other
(also 114 Primates bodymap)
90 bp exon
90 bp exon
1884 bp [gt-ag] intron
28 GenBank accessions
2529 RNA-seq supporting reads
762 UHR pooled cells
1116 Brain
631 Neuroblastoma
20 Other
(also 271 Primates bodymap)
107 bp exon
107 bp exon
272 bp [gt-ag] intron
2 GenBank accessions
96 RNA-seq supporting reads
48 UHR pooled cells
31 Brain
17 Neuroblastoma
(also 14 Primates bodymap)
800 bp exon
800 bp exon
3 accessions, some from brain (seen once)
hypothalamus (once), lung (once)
skin, melanoma, melanotic (once)
small cell carcinoma (once)
800 bp exon
53 bp exon
53 bp exon
4433 bp [gt-ag] intron
17 GenBank accessions
652 RNA-seq supporting reads
101 UHR pooled cells
222 Brain
4 Blood
313 Neuroblastoma
12 Other
(also 471 Primates bodymap)
110 bp exon
5935 bp [gt-ag] intron
15 GenBank accessions
529 RNA-seq supporting reads
94 UHR pooled cells
152 Brain
7 Blood
260 Neuroblastoma
16 Other
(also 438 Primates bodymap)
75 bp exon
22829 bp [gt-ag] intron
4 GenBank accessions
354 RNA-seq supporting reads
72 UHR pooled cells
143 Brain
2 Blood
134 Neuroblastoma
3 Other
(also 4 Primates bodymap)
228 bp exon
1 accession from liver
228 bp exon
207 bp exon
9649 bp [gt-ag] intron
22 GenBank accessions
409 RNA-seq supporting reads
22 UHR pooled cells
168 Brain
1 Blood
204 Neuroblastoma
14 Other
(also 843 Primates bodymap)
144 bp exon
1276 bp [gt-ag] intron
24 GenBank accessions
259 RNA-seq supporting reads
2 UHR pooled cells
106 Brain
2 Blood
121 Neuroblastoma
28 Other
(also 601 Primates bodymap)
87 bp exon
1418 bp [gt-ag] intron
3 GenBank accessions
305 bp exon
3 accessions
Validated 3' end, 1 accession
305 bp exon
321 bp exon
321 bp exon
21 bp uORF
321 bp exon
321 bp exon
11049 bp [gt-ag] intron
27 GenBank accessions
1289 RNA-seq supporting reads
377 UHR pooled cells
546 Brain
3 Blood
336 Neuroblastoma
27 Other
(also 718 Primates bodymap)
56 bp exon
56 bp exon
34275 bp [gt-ag] intron
23 GenBank accessions
1392 RNA-seq supporting reads
427 UHR pooled cells
604 Brain
2 Blood
343 Neuroblastoma
16 Other
(also 537 Primates bodymap)
51 bp exon
51 bp exon
23103 bp [gt-ag] intron
24 GenBank accessions
1635 RNA-seq supporting reads
494 UHR pooled cells
701 Brain
4 Blood
414 Neuroblastoma
22 Other
(also 419 Primates bodymap)
85 bp exon
85 bp exon
1903 bp [gt-ag] intron
28 GenBank accessions
1415 RNA-seq supporting reads
469 UHR pooled cells
556 Brain
363 Neuroblastoma
27 Other
(also 375 Primates bodymap)
136 bp exon
136 bp exon
3020 bp [gt-ag] intron
26 GenBank accessions
1952 RNA-seq supporting reads
617 UHR pooled cells
832 Brain
478 Neuroblastoma
25 Other
(also 437 Primates bodymap)
98 bp exon
98 bp exon
10750 bp [gt-ag] intron
28 GenBank accessions
1233 RNA-seq supporting reads
462 UHR pooled cells
439 Brain
314 Neuroblastoma
18 Other
(also 124 Primates bodymap)
51 bp exon
51 bp exon
686 bp [gt-ag] intron
29 GenBank accessions
1403 RNA-seq supporting reads
543 UHR pooled cells
495 Brain
346 Neuroblastoma
19 Other
(also 114 Primates bodymap)
90 bp exon
90 bp exon
1884 bp [gt-ag] intron
28 GenBank accessions
2529 RNA-seq supporting reads
762 UHR pooled cells
1116 Brain
631 Neuroblastoma
20 Other
(also 271 Primates bodymap)
107 bp exon
107 bp exon
7160 bp [gt-ag] intron
23 GenBank accessions
1186 RNA-seq supporting reads
124 UHR pooled cells
651 Brain
383 Neuroblastoma
28 Other
(also 265 Primates bodymap)
1449 bp exon
1449 bp exon
4 accessions, some from amygdala (seen once)
brain, hypothalamus (once)
hypothalamus (once), melanotic melanoma
cell line (once), skin (once)
capped 5' end, 1 accession
Validated 3' end, 1 accession
1449 bp exon
78 bp exon
78 bp exon
118 bp [gt-ag] intron
3 GenBank accessions
45 RNA-seq supporting reads
40 Brain
5 Other
(also 17 Primates bodymap)
75 bp exon
22829 bp [gt-ag] intron
4 GenBank accessions
354 RNA-seq supporting reads
72 UHR pooled cells
143 Brain
2 Blood
134 Neuroblastoma
3 Other
(also 4 Primates bodymap)
1884 bp exon
3 accessions, some from brain
lung, testis, adult, pooled whole (seen once)
pooled brain, lung, testis (once)
Validated 3' end, 1 accession
1884 bp exon
221 bp exon
221 bp exon
32367 bp [gt-ag] intron
18 GenBank accessions
383 RNA-seq supporting reads
24 UHR pooled cells
162 Brain
4 Blood
171 Neuroblastoma
22 Other
(also 640 Primates bodymap)
106 bp exon
889 bp [gt-ag] intron
21 GenBank accessions
416 RNA-seq supporting reads
13 UHR pooled cells
171 Brain
3 Blood
192 Neuroblastoma
37 Other
(also 599 Primates bodymap)
139 bp exon
4333 bp [gt-ag] intron
13 GenBank accessions
404 RNA-seq supporting reads
24 UHR pooled cells
167 Brain
2 Blood
191 Neuroblastoma
20 Other
(also 600 Primates bodymap)
19 bp exon
1 accession from brain from oligodendroglioma
19 bp exon
512 bp exon
512 bp exon
1 accession from testis
512 bp exon
Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
Read more...
Mouse over the ending of each transcript gives tissues from which the supporting cDNAs were extracted. Details on tissue of origin for each intron and exon is available from the
intron and exons table .
Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. Proteins supported by a single continuous cDNA sequence lead to underlining the name/ending of the variant. Names not underlined result from cDNA concatenation in the coding region and should be experimentally checked.
Introns are depicted by broken lines; the height of the top of each intron reflects the relative number of clones supporting this intron.
]^[ A pink broken line denotes an intron with standard boundaries (gt-ag or gc-ag) that is exactly supported (i.e. a cDNA sequence exactly matches the genome over 16 bp, 8 on both sides of the intron).
] ^ ] A blue broken line denotes non-standard introns, exactly supported, but with non-standard at-ac or any other boundaries.
]-[ Pink and
] - ] blue straight lines represent 'fuzzy' introns of the standard and non-standard types respectively, those introns do not follow the 16 bp rule. Black straight lines ]-[denote gaps in the alignments.
Exons: Wide filled pink areas represent putative protein coding regions, narrow empty pink boxes represent the 5'UTR (on the left) and 3' UTR (on the right). Flags identify validated endings: cap site on the 5' side, polyadenylation site on the 3' side. Filled flags correspond to frequent events while empty flags have lesser supporting cDNAs (yet all are validated); at the 3' side, black flags are associated to the main AATAAA signal,
blue flags to any single letter variant of the main . More explanations are given in the
gene help file