Expression: According to AceView, this gene is expressed at low level, only 18.5% of the average gene in this release. The sequence of this gene is defined by 21 GenBank accessions from 20 cDNA clones, some from kidney (seen 5 times), brain (2), adenocarcinoma cell line (once), hippocampus (once), liver (once), ovary (once), ovary, adenocarcinoma (once) and 5 other tissues. We annotate structural defects or features in 2 cDNA clones.
Alternative mRNA variants and regulation: The gene contains 6 distinct gt-ag introns. Transcription produces 5 different mRNAs, 3 alternatively spliced variants and 2 unspliced forms. There are 2 non overlapping alternative last exons (see the diagram). The mRNAs appear to differ by truncation of the 3' end, presence or absence of a cassette exon.
Function: There are 32 articles specifically referring to this gene in PubMed. Functionally, the gene has been tested for association to diseases (Aortic Diseases; Arteriosclerosis; Breast Neoplasms; Carcinoma, Squamous Cell; Diabetes mellitus, type 2; Genetic Predisposition to Disease; Head and Neck Neoplasms; Lymphoma, B-cell; Neoplasm Invasiveness; Ovarian Neoplasms), proposed to participate in pathway (ErbB signaling pathway) and processes (positive regulation of cell proliferation, negative regulation of apoptosis, positive regulation of cell differentiation, positive regulation of cell division, positive regulation of diuresis, positive regulation of fibroblast proliferation, positive regulation of mitosis). Proteins are expected to have molecular functions (epidermal growth factor receptor binding, growth factor activity) and to localize in various compartments (soluble fraction, extracellular space, membrane, extracellular region, integral to membrane, plasma membrane). Putative protein interactors have been described (EGFR, ERBB2, ERBB4, MMP9).
Protein coding potential: 3 spliced mRNAs putatively encode good proteins, altogether 3 different isoforms (3 complete), some containing EGF-like domain [Pfam], some transmembrane domains [Psort2]; 1 of the 3 complete proteins appears to be secreted. The remaining 2 mRNA variants (2 unspliced; 1 partial) appear not to encode good proteins.

Please quote: AceView: a comprehensive cDNA-supported gene and transcripts annotation, Genome Biology 2006, 7(Suppl 1):S12

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron, the small numbers show the support of the introns in deep sequencing (with details in mouse-over) . Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript.
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