03.004.0.01.001. Porcine reproductive and respiratory syndrome virus ICTVdB

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03.004.0.01.001. Porcine reproductive and respiratory syndrome virus

Structure of arterivirus virions. (Upper right) Electron micrograph of negatively stained particles of Porcine reproductive and respiratory syndrome virus (PRRSV). Bar is 50 nm. (Lower right) Electron micrograph of Equine arteritis virus (EAV) particles, budding from smooth intracellular membranes (BHK-21 cells). The bar represents 50 nm. (Left) Schematic representation of an arterivirus particle. Seven virionassociated proteins have been identified in EAV and PRRSV virions. In addition to the nucleocapsid protein (N), there are two major (GP5 and M) and four minor (GPz, GP, GP4, E) envelope proteins. By reverse genetics (EAV), each of these proteins was shown to be required for the production of infectious progeny. The proteins encoded by ORFs 2a, 3 and 4 have not been identified as structural components of Lactate dehydrogenaseelevating virus (LDV). The virion proteins of Simian hemorrhagic fever virus (SHFV) remain largely uncharacterized. The major virion glycoprotein of arteriviruses (GP5 in EAV, PRRSV, and LDV) forms a disulfide-linked heterodimer with M that is essential for virus infectivity. GPz, GP3, and GP, were recently described to form heterotrimers in the virus particle (EAV).

Low resolution copy of the original in the 8th ICTV Report.

Structure of arterivirus virions. (Upper right) Electron micrograph of negatively stained particles of Porcine reproductive and respiratory syndrome virus (PRRSV). Bar is 50 nm. (Lower right) Electron micrograph of Equine arteritis virus (EAV) particles, budding from smooth intracellular membranes (BHK-21 cells). The bar represents 50 nm. (Left) Schematic representation of an arterivirus particle. Seven virionassociated proteins have been identified in EAV and PRRSV virions. In addition to the nucleocapsid protein (N), there are two major (GP5 and M) and four minor (GPz, GP, GP4, E) envelope proteins. By reverse genetics (EAV), each of these proteins was shown to be required for the production of infectious progeny. The proteins encoded by ORFs 2a, 3 and 4 have not been identified as structural components of Lactate dehydrogenaseelevating virus (LDV). The virion proteins of Simian hemorrhagic fever virus (SHFV) remain largely uncharacterized. The major virion glycoprotein of arteriviruses (GP5 in EAV, PRRSV, and LDV) forms a disulfide-linked heterodimer with M that is essential for virus infectivity. GPz, GP3, and GP, were recently described to form heterotrimers in the virus particle (EAV).

Virus Species	Virus Genus	Virus Family	Host
03.004.0.01.001. Porcine reproductive and respiratory syndrome virus	03.004.0.01. Arterivirus	03.004. Arteriviridae 03. Nidovirales	porcine

Additional References

Species List and Reference List from the 8th ICTV Report
ICTVdB taxon description

References to sequence databases at GenBank and PubMed Central:
PubMed Central References; nucleotide sequences; complete genomes

Comments to ICTVdB Management
Last updated: 15 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002 International Committee on Taxonomy of Viruses. All rights reserved.

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