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00.003.0.01.1. LCMV-LASV complex (OldWorld arenaviruses)

Table of Contents

Taxonomy

Original Source and History of Virus
Virion Properties


Morphology
Physicochemical and Physical Properties
Nucleic Acid
Proteins
Lipids
Carbohydrates

Genome Organization and Replication

Infectivity
Replication
Function of Helper and Satellite Viruses
Cytopathology

Antigenic Properties

Serological Relationships
Diagnosis

Biological Properties

Symptoms and Host Range
Transmission
Geographic Distribution
Ecology and Control
Diagnostic and Methods

Taxonomic Structure
General Comments
References
Data sources and Contributors
Related Databases
Additional Data Sources and Teaching aids

Taxonomy

Virus Code. 00.003.0.01. Virus Accession number 03010000.
Synonym(s): LCM virus group.

Virus infects vertebrates.

Description is on taxonomic level of serogroup. Virus belongs to the genus Arenavirus (VC 00.003.0.01. ); family Arenaviridae (VC 00.003. ).

Properties of Virion

Morphology

Virions enveloped; slightly pleomorphic; spherical. Virions contain probably 2 nucleocapsid(s) per envelope. Virions (50-)110-130(-300) nm in diameter. Surface projections of envelope distinct; club-shaped (about 10 nm long); in small numbers dispersed evenly over all the surface. Host ribosomes seen inside the envelope (in varying numbers). Nucleocapsids filamentous (. isolated nucleocapsids, free of contaminating host ribosomes, are organised in closed circles and display a linear array of nucleosomal subunits); (450-)1000-1300 nm long; 9-15 nm in diameter. Symmetry helical.

Nucleic Acid

Virions contain 2 % nucleic acid. Virions contain two segments of (RNA L and S) linear single stranded RNA.

Total genome length is 10000-11000 nt. The largest segment ~7400 nt; of second largest ~3400 nt. Nucleotide sequences of 3'-terminus largely complementary to similar regions on the 5' end; conserved nucleotide sequences; the same in species of same genus; S on RNA; 19-30 nucleotides long. Encapsidated nucleic acid both genomic and non-viral; including three molecules of host ribosomal RNA. Genome found in one type of particle only. Each virion contains multiple copies of genome; often segments of genome not in equimolar proportions (due to frequent packaging of S RNA strands).

Lipids

Virions contain 20 % lipid.

Antigenic Properties

Serological Relationships

Sequence homologies more than 50% between species.

Taxonomic Structure

Taxonomic structure of the serogroup.
Type species: 00.003.0.01.001 lymphocytic choriomeningitis virus.
Species: 00.003.0.01.002 Ippy virus avis-A0181; 00.003.0.01.003 Lassa virus; 00.003.0.01.004 lymphocytic choriomeningitis virus; 00.003.0.01.005 Mobala virus; 00.003.0.01.006 Mopeia virus.

References

The following references are cited in the ICTV Report : rf_arena.htm.

Data sources and contributors.

The above description has been compiled from the data presented in the Sixth ICTV Report by Buchmeier MJ, Clegg JCS, Franze-Fernandez MT, Kolakofsky D, Peters CJ, Southern PJ.

The description has been generated automatically from DELTA files.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

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Last updated: 15 June 2004 by Cornelia Büchen-Osmond
Web Page generated from ICTVdB by the DELTA systems.

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