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03.019.0.01.014.00.193.001. SARS-Coronavirus Frankfurt 1

Cite this publication as: ICTVdB Management. 03.019.0.01.014.00.193.001. SARS-Coronavirus Frankfurt 1. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), ICTVdB Management, Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Isolation Details

Isolate designation: Frankfurt 1.
Isolation date: 15 March; 2003.
Location: Singapore.
Source of isolate: human.

Virus was isolated by Prof Dr Hans Wilhelm Doerr; Insitute for Medical Virology, University hospital of Frankfurt Main, Paul Ehrlich Str. 40, 60506 Frankfurt am Main, Germany. Email: H.W.Doerr@em.uni-frankfurt.de. Involved in the submission of the isolate was also Dr. Christian Drosten; Bernhard-Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany; Prof. Dr. Jindrich Cinatl; Dr. Wolfgang Preiser; Institute for Medical Virology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany; Dr. Stephan Gunther; Institute for Virology, Hans-Meerweinstraße 2 35043 Marburg, Germany.

Reference: Drosten, C., Gunther, S., Preiser, W., et. al. (2003) Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory Syndrome, New England Jour. PubMed ID to this reference is [12690091].

Classification

This is a description of a vertebrate virus at the isolate level.

ICTVdB Virus Code: 03.019.0.01.014.00.193.001. Virus accession number: SARSI017. Former accession number: 40FC00AE. NCBI Taxonomy ID: [229992].

Name, Synonyms and Lineage

Acronym(s): FFM-ic. Virus is assigned to species 03.019.0.01.014. Severe acute respiratory syndrome coronavirus. Virus is assigned to the genus 03.019.0.01. Coronavirus ; assigned to the family 03.019. Coronaviridae ; assigned to the order 03. Nidovirales .

Depositories and Collections

The isolate has been deposited at the Bernhard Nocht Institute for Tropical Medicine.

Virion Properties

Introduction

Particles contain nucleic acid.

Virion Properties

Morphology

Virions consist of an envelope, spikes, and a nucleocapsid.

Nucleic Acid

The genome is not segmented and consists of a single molecule of linear, positive-sense, single-stranded RNA. The complete genome is this length excludes the 3' poly-A tail 29727 nucleotides long. The RNA has been fully sequenced and complete sequence is 29727 nucleotides long; sequence can be accessed at GenBank with the accession number [AY291315]. The 3'-terminus has a poly (A) tract 13 nucleotides in length. Reference to nucleotide sequence PubMed ID: [12917450].

Biological Properties

Natural Host Range

Viral hosts belong to the Domain Eucarya.

Domain Eucarya Kingdom Animalia.

Kingdom Animalia Phylum Chordata.

Phylum Vertebrata Subphylum Vertebrata.

Class Mammalia.

Class Mammalia Order Primates;
Family Hominidae; virus infects Homo sapiens (human).

Host and isolation details Virus was isolated from an adult. Virus was isolated from sputum.

General Symptoms in Animals Infection can affect the respiratory system, hematopoiesis, and dermis, mucosa or epithelium. General symptoms include fever and rashes. Signs and symptoms include erythema on the trunk; cough, pharyngitis (bilateral opacifications seen in chest radiograph); other: hypoxemia leukopenia (and lymphopenia).

Severity and Occurrence of Disease

Host 1: Infection is apparent and clinically expressed. Signs and symptoms disappear soon after infection (Convalescence began on day 10).

Comments

This isolate has a genome identical to that of SARS CoV FRA. The Frankfurt 1 patient is the husband of the FRA patient.

Contributor

Data have been submitted online to ICTVdB on 01-12-05 by
Sara Mullins
American Type Culture Collection
George Mason University
PW II, 10801 University Boulevard
Manassas, VA 20110
United States of America
Tel: + 703-365-2700.
Fax: + 703-365-2701.
Email: Sara Mullins.



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

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Last updated on 22 April 2008 by Cornelia Büchen-Osmond
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