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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

01.062.0.02. Lyssavirus

Cite this publication as: ICTVdB Management (2006). 01.062.0.02. Lyssavirus. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Classification

This is a description of a vertebrate virus at the genus level.

ICTVdB Virus Code: 01.062.0.02. Virus accession number: 062002GE. Obsolete virus code: 62.0.2.; superceded accession number: 62020000.
NCBI Taxon Identifier NCBI Taxonomy ID: 11286.

Name, Synonyms and Lineage

Synonym(s): Rabies virus group. Virus is of the family 01.062. Rhabdoviridae; order 01. Mononegavirales.

Virion Properties

Morphology

Virions consist of an envelope and a nucleocapsid. Virus capsid is enveloped. Virions are bullet-shaped. Virions measure 45-100 nm in diameter; 100-430 nm in length. Surface projections are densely dispersed, distinctive spikes that cover the whole surface except for the quasi-planar end. Capsid/nucleocapsid is elongated with helical symmetry. The nucleocapsid is uncoiled filamentous, or cylindrical (coiled, is cross-banded with a length of uncoiled about 700 nm and a width of uncoiled 20 nm, or 30-70 nm.

Physicochemical and Physical Properties

Virions have a buoyant density in sucrose of 1.19-1.2 g cm-3.

Nucleic Acid

The Mr of the genome constitutes 1-2% of the virion by weight. The genome is not segmented and contains a single molecule of linear, negative-sense, single-stranded RNA. The complete genome is 11900 nucleotides long. Nucleotide sequences at the 3'-terminus are are inverted and complementary to similar regions on the 5' end. The 3'-terminus has conserved nucleotide sequences; in species of same genus; sequence has includes about 60 nucleotides in length (leader sequence that precedes N). Each virion contains a full length copy, or shorter copies.

GenBank records for nucleotide sequences; complete genome sequences.

Proteins

Proteins constitute about 65-75% of the particle weight (structural).

The viral genome encodes structural proteins and non-structural proteins.

Lipids

Lipids are present and located in the envelope and protein (G that has a covalently associated fatty acid proximal to the lipid envelope). Virions are composed of 15-25% lipids by weight. The composition of viral lipids and host cell membranes are similar. The lipids are of host origin and are derived from host cell membranes. Viral membranes include 55-60% phospholipids, sterols, and glycolipids.

Polyamines

Other compounds that have been detected in the virus particles are 3% carbohydrates.

Biological Properties

Natural Host

Virus infects during its life cycle a single type of vertebrate host.
Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Chordata.

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Primates and Carnivora;
Family Hominidae.
Virus infects Homo sapiens (human).

Ecology, Epidemiology and Control

A fact sheet on this virus is available from the World Health Organization (WHO)

Taxonomic Structure of the Genus

Type species 01.062.0.02.001. Rabies virus .

Species in the Genus

List of Species in the Genus.
Tentative Species in the Genus.

Data Sources and Contributions

The description has been compiled from data in the ICTV Report presented by Wunner WH, Calisher CH, Dietzgen RG, Jackson AO, Kitajima EW, Lafon M, Leong JC, Nichol S, Peters D, Smith JS, Walker PJ.

References

The following generic references are cited in the most recent ICTV Report.

PubMed References.
A description of the virus is found at the Animal Health Laboratory, Geelong, Australia: (

Taxonomic Proposals and Changes

At present, broadly cross-reacting antigenic sites on the N protein, as recognised by immunofluorescence and complement fixation, determine placement within the Lyssavirus genus. More specific antigenic sites on the G protein, as recognised in neutralisation tests, determine the placement of a virus isolate as rabies or rabies-related. Cross-neutralisation by rabies virus antisera may be moderate (EBV-1, EBV-2, DUVV), to very low (LBV, MOKV), to none (KOTV, OBOV, RBUV). Only one serogroup within the genus has been established. However, the taxonomic significance of the antigenic data is not known. BEFV, which has previously been linked to the lyssaviruses by such data, exhibit greater sequence similarities (albeit distant) to vesiculoviruses than to lyssaviruses. In view of the BEFV results, the postulated assignments of some viruses (KOTV, OBOV, RBUV) to the genus remains to be confirmed. Sequence data are only available for a few lyssaviruses.



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002    International Committee on Taxonomy of Viruses.    All rights reserved.


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