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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.073.0.01.019. O'nyong-nyong virus

Cite this publication as: ICTVdB Management (2006). 00.073.0.01.019. O'nyong-nyong virus . In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Isolate Description

Isolation date: 03 October 1959.
Location: northwestern Uganda; Uganda.

Host of Isolate and Habitat Details
Source of isolate: from blood of infected patients and from mosquitoes (Anopheles funestus and Anopheles gambia).

Collection and Isolation Details
Virus was isolated by unknown.

Biocontainment Level

Distribution of this virus falls under quarantine restrictions. It is recommended to handle this virus at the biocontainment level BSL-2.

Classification

This is a description of an invertebrate or vertebrate virus at the species level with data limited to classification details. If you have primary data on this virus, please submit them to ICTVdB using the online data entry systems or contact the ICTVdB management.

ICTVdB Virus Code: 00.073.0.01.019. Virus accession number: 73001019. Obsolete virus code: 73.0.1.0.019; superceded accession number: 73010019.
NCBI Taxon Identifier NCBI Taxonomy ID: 11027.

Name, Synonyms and Lineage

The taxon has the accepted ICTV name.

ICTV approved acronym: (ONNV). Virus is an ICTV approved species. Virus is of the genus 00.073.0.01. Alphavirus in the family 00.073. Togaviridae; not assigned to an order.

Virion Properties

Morphology

Virions consist of an envelope and a nucleocapsid. During their life cycle, virions have not been observed outside a cellular environment and have a cell-associated cycle. Virus capsid is enveloped (with a tight fitting membrane). Virions are spherical and measure about 70 nm in diameter. Surface projections are distinctive glycoprotein spikes covering evenly the surface. Capsid/nucleocapsid is round and exhibits icosahedral symmetry (T=4). The nucleocapsid is isometric and has a diameter of about 40 nm. Capsids appear round.

Nucleic Acid

The genome is not segmented and contains a single molecule of linear positive-sense, single-stranded RNA. The complete genome is 11835 nucleotides long. Sequence can be accessed from GenBank; the RNA is fully sequenced, complete sequence is 11835 nucleotides long. NCBI reference genome has the accession number [NC-001512]. The 5'-end of the genome has a methylated nucleotide cap. The 3'-terminus has a poly (A) tract.

Reference to nucleotide sequence in PubMed: reference(s). GenBank records for nucleotide sequences; complete genome sequences.

Proteins

The viral genome encodes structural proteins and non-structural proteins.

Antigenicity

The virus is serologically related to all viruses in the genus alphavirus, especially to the Semliki Forest antigenic complex.

The virus is closely related to Chikungunya virus and related to Semliki Forest antigenic complex.

Biological Properties

Natural Host

Virus infects during its life cycle arthropod and vertebrate hosts. Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Arthropoda and Chordata.

Phylum Arthropoda
Subphylum Hexapoda; Class Insecta; Subclass Pterygota (winged insects), Order Diptera.

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Primates;
Family Hominidae.
Virus infects Homo sapiens (human).

General Symptoms in Animals Infection can affect the musculo-skeletal system, or dermis, mucosa or epithelium. General symptoms include conjunctivitis, or fever, or headache, or rashes. Lesions are found in musculo-skeletal tissue.

Severity and Occurrence of Disease

Host: Although disease expression is dependent on dose, infection is usually subacute. The infection is clinically expressed. Signs and symptoms may vary, but are usually mild.

Transmission and Vector Relationships

Virus is transmitted by a vector.

Vector Transmission:
Virus is transmitted by arthropods, insects.

Geographical Distribution

Geographical distribution of the virus is probably restricted. The virus spreads in Africa.

List of Strains and Isolates in the Species

IPD A 234, IbH12628, SG650, Gulu.

References

Strauss EG, Levinson R, Rice CM, Dalrymple J. and Strauss JH (1988). Nonstructural proteins nsP3 and nsP4 of Ross River and O'Nyong-nyong viruses: sequence and comparison with those of other alphaviruses. Virology 164, 265-274.

The following generic references are cited in the most recent ICTV Report.

PubMed References.



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

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Last updated on 25 April 2006 by Cornelia Büchen-Osmond
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