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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.061.1.01.004. Mouse mammary tumor virus

Cite this publication as: ICTVdB Management (2006). 00.061.1.01.004. Mouse mammary tumor virus. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/index.htm

Table of Contents

Classification

This is a description of a vertebrate virus at the species level.

ICTVdB Virus Code: 00.061.1.01.004. Virus accession number: 61101004. Obsolete virus code: 00.061.0.01.004.; 61.0.1.0.004; superceded accession number: 61001004; 61010004.
NCBI Taxon Identifier NCBI Taxonomy ID: 11757.

Name, Synonyms and Lineage

ICTV approved acronym: MMTV. Virus is the type of the genus 00.061.1.01. Betaretrovirus; subfamily 00.061.1. Orthoretrovirinae in the family 00.061. Retroviridae.

Morphology

Virions consist of an envelope, a nucleocapsid, and a nucleoid. Virus capsid is enveloped. Virions are spherical to pleomorphic. Virions measure 80-100 nm in diameter. Surface projections are densely dispersed, distinctive glycoprotein spikes that cover evenly the surface. Surface projections are 8 nm long. The nucleoid is eccentric. The core is spherical.

Only one species is recovered in preparations.

Nucleic Acid

The Mr of the genome constitutes 2% of the virion by weight. The genome is dimeric; not segmented and contains a single molecule of linear. The genome is -RT. The genome is positive-sense, single-stranded RNA. The complete genome is of one monomer 10000 nucleotides long. The 5'-end of the genome has a methylated nucleotide cap; cap sequence type is of type 1 m7G5ppp5'GmpNp. The 3'-terminus has of each monomer a poly (A) tract. The 3'-terminus has a tRNA-like structure.

GenBank records for nucleotide sequences; complete genome sequences.

Proteins

Proteins constitute about 60% of the particle weight.

The viral genome encodes structural proteins and non-structural proteins.

Non-Structural Proteins: The virus codes for an RNA-dependent DNA polymerase.

Lipids

Lipids are present and located in the envelope. Virions are composed of 35% lipids by weight. The composition of viral lipids and host cell membranes are similar. The lipids are of host origin and are derived from plasma membranes.

Polyamines

Other compounds that have been detected in the virus particles are 3% carbohydrates.

Genome Organization and Replication

By itself, genomic nucleic acid is not infectious.

Translation: Replication involves a reverse transcription step.

Biological Properties

Natural Host

Virus infects during its life cycle a single type of vertebrate host.
Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Chordata.

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Rodentia.

References

The following generic references are cited in the most recent ICTV Report.

PubMed References.



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002    International Committee on Taxonomy of Viruses.    All rights reserved.


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