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00.060.0.03.001. Rotavirus
A
Cite this publication as: ICTVdB Management (2006).
00.060.0.03.001. Rotavirus A. In: ICTVdB - The Universal Virus Database,
version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA
Cite this site as: ICTVdB - The Universal Virus Database, version 4.
http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/
This is a description of a
vertebrate virus at the species level.
ICTVdB Virus Code: 00.060.0.03.001. Virus accession number:
60003001. Obsolete virus code: 60.0.3.0.001; superceded accession number:
60030001.
NCBI Taxon Identifier NCBI Taxonomy ID:
28875.
Name, Synonyms and Lineage
ICTV approved
acronym: RV-A. Acronym(s): ROTAV-A. Virus is the type of the
genus 00.060.0.03.
Rotavirus in the family
00.060.
Reoviridae.
Virions consist of a capsid, a core, and a nucleoprotein
complex. Virus capsid is not enveloped. Capsid/nucleocapsid is isometric with
icosahedral symmetry and has a diameter of 80 nm. The capsid shells of virions are
composed of two layers. The outer capsid consists of a smooth. The outer shell
is often lost during preparation. Capsids appear round. The capsid surface
structure reveals a regular pattern with distinctive features that appears
wheel-like and is smooth. Surface projections are often lost during
preparation, or distinct, short spikes extending from the 60 vertices
(4.5-6 nm from the surface of the virus particle). Inner capsids consists
of a rough shell; have a diameter of about 50 nm. Virus preparations contain one
particle component. The core is spherical with a diameter of 35 nm.
Only one species is recovered in preparations. Incomplete
particles are found. They are devoid of nucleic acid characterized by capsids
with dark centers in negative stain preparations, or incompletely assembled
capsids.
Electron micrograph of human rotavirus isolated from stool specimens by C. Büchen-Osmond .
The Mr
of the genome constitutes 16% of the virion by weight (cores of 25%). The genome
is segmented and consists of eleven segments of linear
double-stranded RNA. The complete genome is 18556 nucleotides
long. Sequence can be accessed from EBI-EMBL, or GenBank, or DNA Data Bank of
Japan; the RNA-1 is fully sequenced, complete sequence is 3302
nucleotides long and encodes structural protein VP1. Sequence has
the accession number
[X16830]. RNA-2 is fully sequenced, complete sequence is
2690 nucleotides long and encodes structural protein VP2;
has the accession number
[X16831]. RNA-3 is fully sequenced, complete sequence is
2591 nucleotides long and encodes core protein VP3 has
the accession number
[X16062]. RNA-4 has been fully sequenced, complete
sequence is 2362 nucleotides long and encodes core protein VP3,
has the accession number
[X14204]. RNA-5 has been fully sequenced, complete
sequence is 1611 nucleotides long and encodes non-structural
protein NS53 has the accession number
[X14914]. RNA-6 has been fully sequenced, complete
sequence is 1357 nucleotides long and encodes major inner capsid
protein has the accession number
[X00421]. RNA-7 has been fully sequenced, complete
sequence is 1104 nucleotides long and encodes non-structural
protein NCVP4 has the accession number
[X00355]. RNA-8 has been fully sequenced, complete
sequence is 1059 nucleotides long and encodes non-structural
glycoprotein protein NCVP3 has the accession number
[J02353]. RNA-9 has been fully sequenced, complete
sequence is 1062 nucleotides long and encodes major outer capsid
protein has the accession number
[K02028]. RNA-10 has been fully sequenced; complete sequence is
751 nucleotides long and encodes glycoprotein NCVP5 has
the accession number
[K01138]. RNA-11 has been fully sequenced, complete
sequence is 667 nucleotides long and encodes putative capsid layer
component has the accession number
[X07831]. The 5'-terminal sequence has conserved regions; 5'-end of
the genome has a methylated nucleotide cap; cap sequence type is m7G5ppp5'GmpNp.
The 5'-terminus has no poly (C) tract. The 3'-terminus has conserved
nucleotide sequences; sequence has conserved regions. The multipartite genome is
divided among different particles, each segment encapsidated separately. Each
virion contains a single copy of the genome; usually a full length copy.
GenBank records for
nucleotide sequences;
complete genome sequences.
Proteins
constitute about 84% of the particle weight (cores of 75%).
The viral genome encodes structural proteins and non-structural proteins.
Lipids are
absent.
Natural Host
Virus infects during its life cycle a single type of vertebrate host.
Domain
Viral hosts belong to the Domain Eucarya.
Domain Eucarya
Kingdom Animalia.
Kingdom Animalia
Phylum Chordata.
Phylum Vertebrata
Subphylum Vertebrata.
Class Aves, or Mammalia.
Class Mammalia Order Primates;
Family
Hominidae.
Virus infects Homo sapiens (human).
Virus is not transmitted by a vector inan indirect
manner.
The
following generic references are cited in the most recent ICTV Report.
PubMed References.
Taxon images: • EM by Cornelia Büchen-Osmond.
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