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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.047.0.01.001. Simian virus 40

Cite this publication as: ICTVdB Management (2006). 00.047.0.01.001. Simian virus 40. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Classification

This is a description of a vertebrate virus at the species level.

ICTVdB Virus Code: 00.047.0.01.001. Virus accession number: 47001001. Obsolete virus code: 47.0.1.0.013; superceded accession number: 47010013.
NCBI Taxon Identifier NCBI Taxonomy ID: 10633.

Name, Synonyms and Lineage

ICTV approved acronym: SV-40. Virus is the type of the genus 00.047.0.01. Polyomavirus in the family 00.047. Polyomaviridae.

Virion Properties

Morphology

Virions consist of a capsid. Virus capsid is not enveloped, round with icosahedral symmetry (T=7). The capsid is isometric and has a diameter of 48.8-49.7 nm. Capsids appear round. The capsomer arrangement is clearly visible. The capsid consists of 72 capsomers (, each of which is composed of five copies of VP1 in skew arrangement). Surface projections are small and surface appears rough.

Capsids can be penetrated by stain and some appear dark in the center. Incomplete particles are common and morphologically aberrant forms are observed. They are devoid of nucleic acid characterized by capsids with dark centers in negative stain preparations and filamentous or tubular in form as result of aberrant maturation.



















Capsid structures, detailed structural and computational analysis are found in the Protein Data Bank (PDB) using VIPERdB, the VIrus Particle ExploreR 1sva.

Nucleic Acid

The Mr of the genome constitutes 12% of the virion by weight. The genome is not segmented and contains a single molecule of circular, supercoiled, double-stranded DNA that forms a covalently closed circle. Minor species of non-genomic nucleic acid are also found in virions. The encapsidated nucleic acid is mainly of genomic origin, but virions may also contain nucleic acid of host origin including fragments of host DNA (in one type of particles). The complete genome is 5000 nucleotides long and is fully sequenced. Sequence has the accession number [J02400]. The genome has a guanine + cytosine content of 40-50 %.

GenBank records for nucleotide sequences; complete genome sequences.

Proteins

The viral genome encodes structural proteins located in the capsid.

Structural Proteins: Capsid protein VP1. Capsid protein has a molecular mass of 40165 Da (364 AA) with 360 copies per virion; sequence has the accession number [P03087]; is the coat protein.

Lipids

Lipids are absent.

Biological Properties

Natural Host

Virus infects during its life cycle a single type of vertebrate host.
Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Chordata.

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Primates;
Family Hominidae.
Virus infects Homo sapiens (human).

References

The following generic references are cited in the most recent ICTV Report.

PubMed References.

Taxonomic Proposals and Changes

A taxonomic proposal has been submitted to the ICTV by the Vertebrate Virus Subcommittee, Study Group for Papovaviridae to reclassify the position of type species. The proposal has been approved by postal ballot following discussions at the meeting of the Executive Committee in San Diego, 1998, the taxon has been designated as Type Species.

Images

Taxon images: • SV40 http://bilbo.bio.purdue.edu/~baker/projects/papova/sv40/sv40.html.



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002    International Committee on Taxonomy of Viruses.    All rights reserved.


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