Descriptions are
generated automatically from the ICTVdB database including links. Some
descriptions are only very basic and links may point to documents that are not
yet published on the Web.
00.046.0.04.001. Influenza B
virus
Cite this publication as: ICTVdB Management (2006).
00.046.0.04.001. Influenza B virus. In: ICTVdB - The Universal Virus
Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New
York, USA
Cite this site as: ICTVdB - The Universal Virus
Database, version 4.
http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/
This is a description of a
vertebrate virus at the species level.
ICTVdB Virus Code: 00.046.0.04.001. Virus accession number:
46004001. Obsolete virus code: 46.0.4.0.001; superceded accession number:
46040001.
NCBI Taxon Identifier NCBI Taxonomy ID:
11520.
Name, Synonyms and Lineage
ICTV approved
acronym: FLUBV. Virus is the type of the genus
00.046.0.04.
Influenzavirus B in the family
00.046.
Orthomyxoviridae.
Virions consist of an envelope, a matrix protein, a
nucleoprotein complex, a nucleocapsid, and a polymerase complex. Virus capsid is
enveloped. Virions are spherical to pleomorphic; filamentous forms occur
(sometimes). Virions measure 80-120 nm in diameter;
200-300(-3000) nm in length. Surface projections are densely
dispersed, about 500 clustered, distinctive spikes that cover the surface evenly and
comprise major
glycoprotein hemagglutinin and neuraminidase are interspersed in a ratio of HA
to NA about 4-5 to 1. Surface projections are composed of different types
of proteins. Surface projections are 10-14 nm long; 4-6 nm in
diameter. Capsid/nucleocapsid is elongated with helical
symmetry. The nucleocapsid is helical; and segments have different size
classes with a length of 50-130 nm. The nucleocapsids are segmented with
loops at one end.
The molecular mass (Mr) of virions is 250 x 106.
Virions have a buoyant density in sucrose of 1.19 g cm-3. The
sedimentation coefficient is 700-800 S20w (for
non-filamentous particles). Virions are very sensitive. Virions are sensitive to
treatment with heat, lipid solvents, non-ionic detergents, formaldehyde,
oxidizing agents. The infectivity is reduced after exposure to irradiation.
The
genome is segmented and consists of eight segments of linear
negative-sense, single-stranded RNA. The complete
genome is 14648 nucleotides long. The segment 1 is fully sequenced.
Complete sequence is 2396 nucleotides long. Segment 2 is
sequenced, complete sequence is about 2386
nucleotides long. Segment 3 is fully sequenced, complete
sequence is 2304 nucleotides long. Segment 4 has been fully sequenced.
Complete sequence is 1882 nucleotides long. Segment 5 has been
sequenced, but only an estimate is presented, complete sequence is 1841
nucleotides long. Segment 6 has been sequenced, but only an estimate
is given, complete sequence is 1557 nucleotides long. Segment 7
has been sequenced, but only an estimate is presented,
complete sequence is 1191 nucleotides long, has been sequenced, but
only an estimate is available; complete sequence is 1096 nucleotides long. The
genome has terminally redundant sequences. The genome sequence is repeated at
both ends. Nucleotide sequences at the 3'-terminus are identical. The
5'-terminal sequence has conserved regions and repeats complementary to the
3'-terminus (5'-AGUAG(A/U)AACAA..., terminal repeats at the
5'-end are 11 nucleotides long. The 3'-terminus has conserved
nucleotide sequences; of 12 nucleotides in length; in viruses of same species;
sequence has conserved regions (3'-UCGU(U/C)UUCGUCC..., in all RNA species. The
multipartite genome is encapsidated, each segment in a separate nucleocapsid,
and the nucleocapsids are surrounded by one envelope. Each virion contains
defective interfering copies (may be present).
GenBank records for
nucleotide sequences;
complete genome sequences.
The viral
genome encodes structural proteins and non-structural proteins.
Lipids are
present and located in the envelope. Virions are composed of
18-37% lipids by weight. The composition of viral lipids and host cell
membranes are similar. The lipids are modified cellular lipids and
are derived from plasma membranes. Proteins of host derived membranes have been
modified during post-translational processes. Host-derived membranes contain
viral proteins in place of host proteins.
Natural Host
Virus infects during its life cycle a single type of vertebrate host.
Domain
Viral hosts belong to the Domain Eucarya.
Domain Eucarya
Kingdom Animalia.
Kingdom Animalia
Phylum Chordata.
Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.
Class Mammalia
Order Primates;
Family
Hominidae.
Virus infects Homo sapiens (human).
Virus is transmitted by contact between hosts.
The
following generic references are cited in the most recent ICTV Report.
PubMed References.
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