Descriptions are
generated automatically from the ICTVdB database including links. Some
descriptions are only very basic and links may point to documents that are not
yet published on the Web.
00.046.0.03.001. Thogoto
virus
Cite this publication as: ICTVdB Management (2006).
00.046.0.03.001. Thogoto virus. In: ICTVdB - The Universal Virus
Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New
York, USA
Cite this site as: ICTVdB - The Universal Virus
Database, version 4.
http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/
Biocontainment Level
Distribution of this virus
falls under quarantine restrictions. It is recommended to handle this virus at
the biocontainment level BSL-3.
This is a description of an
invertebrate or vertebrate virus at the species
level.
ICTVdB Virus Code: 00.046.0.03.001. Virus accession number:
46003001. Obsolete virus code: 46.0.3.0.001; superceded accession number:
46030001.
NCBI Taxon Identifier NCBI Taxonomy ID:
11569.
Name, Synonyms and Lineage
ICTV approved
acronym: THOV. Virus is the type of the genus
00.046.0.03.
Thogotovirus in the family
00.046.
Orthomyxoviridae.
Virions consist of an envelope, a matrix protein, a
nucleoprotein complex, a nucleocapsid, and a polymerase complex. Virus capsid is
enveloped. Virions are spherical to pleomorphic; filamentous forms occur
(sometimes). Virions measure 80-120 nm in diameter;
200-300 nm in length. The envelope surrounds one nucleocapsid. Surface projections are densely
dispersed, distinctive spikes that cover the surface evenly and
comprise
esterase-esterase. Surface projections are composed of one type of protein.
Surface projections are 10-14 nm long; 4-6 nm in diameter.
Capsid/nucleocapsid is elongated with helical
symmetry.
The nucleocapsid is helical; and segments have different size classes;
with a length of 50-130 nm. The nucleocapsids
are segmented with loops at one end.
The molecular mass (Mr) of virions is 250 x 106.
Virions have a buoyant density in sucrose of 1.19 g cm-3. The
sedimentation coefficient is 700-800 S20w (for
non-filamentous particles). Virions are sensitive. Virions are sensitive to
treatment with heat, lipid solvents, non-ionic detergents, formaldehyde,
oxidizing agents. The infectivity is reduced after exposure to irradiation.
The
genome is segmented and consists of six segments of linear
negative-sense, single-stranded RNA. The complete
genome is 10000 nucleotides long. The segment 1. Segment 2 is sequenced,
complete sequence is about 2200-2250
nucleotides long. Segment 4 has been fully sequenced.
Complete sequence is 1574 nucleotides long and has been sequenced, but only
an estimate is presented, complete sequence is 1500 nucleotides long.
Segment 6 has been sequenced,
complete sequence is 900-1000 nucleotides long. The genome has terminally
redundant sequences. The genome sequence is repeated at both ends. The
5'-terminal sequence has conserved regions and repeats complementary to the
3'-terminus (5'-AGAGA(U/A)AUCAAAAGC..., terminal repeats at the
5'-end are 14 nucleotides long. The 3'-terminus has conserved
nucleotide sequences; of 11 nucleotides in length; sequence has conserved
regions (3'-UCGUUUUGUUC..., in all RNA species, or some RNA segments. The
multipartite genome is encapsidated, each segment in a separate nucleocapsid,
and the nucleocapsids are surrounded by one envelope.
GenBank records for
nucleotide sequences;
complete genome sequences.
The viral
genome encodes structural proteins and non-structural proteins.
Lipids are
present and located in the envelope. Virions are composed of
18-37% lipids by weight. The composition of viral lipids and host cell
membranes are similar. The lipids are modified cellular lipids and
are derived from plasma membranes. Proteins of host derived membranes have been
modified during post-translational processes. Host-derived membranes contain
viral proteins in place of host proteins.
Natural Host
Virus infects during its life cycle arthropod and vertebrate hosts. Domain
Viral hosts belong to the Domain Eucarya.
Domain Eucarya
Kingdom Animalia.
Kingdom Animalia
Phylum Arthropoda, or
Chordata.
Phylum Arthropoda
Subphylum Hexapoda; Class
Arachnida.
Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.
Class Mammalia
Order Primates;
Family
Hominidae.
Virus infects Homo sapiens (human).
Virus is transmitted by a vector in a direct manner.
Virus is transmitted by contact between hosts.
Vector Transmission:
Virus is transmitted by arthropods;
arthropod-borne virus is transmitted by arachnids; arthropod-borne virus is
transmitted by ticks. Virus is transmitted in a non-persistent manner;
retained when the vector moults; replicates in the vector.
List of Strains and
Isolates in the Species
The
following generic references are cited in the most recent ICTV Report.
PubMed References.
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