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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.030.0.01.003.04.005. Hepatitis B virus - D, subtype adr4

Cite this publication as: ICTVdB Management (2006). 00.030.0.01.003.04.005. Hepatitis B virus - D, subtype adr4. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Isolate Description

Isolate designation: ayw.
Isolation date: 1979.
Location: not specified.

Host of Isolate and Habitat Details
Source of isolate: not specified.

Collection and Isolation Details
Virus was isolated by unknown.

Classification

This is a description of a vertebrate virus at the isolate level.

ICTVdB Virus Code: 00.030.0.01.003.04.005. Virus accession number: 30001453.
NCBI Taxonomy Identifier Taxon ID: 10418.

Name, Synonyms and Lineage

Virus is assigned to species 00.030.0.01.003. Hepatitis B virus of the genus 00.030.0.01. Orthohepadnavirus in the family 00.030. Hepadnaviridae.

Virion Properties

Morphology

Virions consist of an envelope and a nucleocapsid. Virus capsid is enveloped by a detergent sensitive lipoprotein (7 nm). Virions are spherical to pleomorphic (at times, filamentous forms occur and spherical structures that lack cores are common (HBsAg particles). Virions measure 40-48 nm in diameter, or 22 nm in diameter (for the HBsAg particles of variable length). The envelope has no surface projections. Capsid/nucleocapsid is round and exhibits icosahedral symmetry. The nucleocapsid is isometricand has a diameter of 27 nm. The capsid surface structure frequently reveals a regular pattern with distinctive features (concentric rings). The capsid consists of 180 capsomers.

Capsids can be penetrated by stain and some appear dark in the center (that are the nucleic-acid free 22 nm lipoprotein particles (HBsAg) which are antigenically similar to the envelope and occur naturally in sera of infected patients). Incomplete particles are common.






















Capsid structures, detailed structural and computational analysis are found in the Protein Data Bank (PDB) using VIPERdB, the VIrus Particle ExploreR Hepatitis B virus.

Nucleic Acid

The genome is not segmented and contains a single molecule of circular. The genome is -RT. The genome is partially double-stranded DNA that forms a covalently closed circle (with 5' end of the full length minus strand which is linked to the viral DNA polymerase). Sequence can be accessed from GenBank. The DNA is partially sequenced, sequenced region is 3182 nucleotides long. Sequence has the accession number [V01460] (replaces J02203).

The genome has a guanine + cytosine content of 48 %. The genome sequence has termini with cohesive ends (that match the uniquely located 5'-ends of the two strands which overlap by approximately 240 nucleotides and maintain the circular configuration of the DNA). The negative-sense or non-coding strand (complementary to the viral mRNA) is full-length; positive sense strand (the viral mRNA) is shorter than full-length. The double stranded genome has a nick at a unique site on full length negative strand opposite at a position 242 nucleotides downstream from the 5' end of the positive sense strand. The 5'-end of the negative-sense strand has a covalently attached terminal protein; positive-sense strand has a 5' capped oligoribonucleotide primer. The 3'-terminus has conserved nucleotide sequences; of 1 nucleotides in length.

Reference to nucleotide sequence in PubMed: reference(s). GenBank records for nucleotide sequences; complete genome sequences.

Proteins

The viral genome encodes structural proteins and non-structural proteins located in the envelope and capsid.

Non-Structural Proteins: The virus codes for an RNA-dependent DNA polymerase.

Lipids

Lipids are present and located in the envelope and empty particles (HBsAG components). The composition of viral lipids is known. The composition of viral lipids and host cell membranes are similar. The lipids are derived from a host membrane compartment intermediate between and are derived from endoplasmatic reticulum membranes and Golgi membranes. Viral membranes include phospholipids, cholesterol, cholesterol esters, and triglycerides.

Translation: Replication involves a reverse transcription step.

Biological Properties

Natural Host

Virus infects during its life cycle a single type of vertebrate host.
Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Chordata.

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Primates;
Family Hominidae.
Virus infects Homo sapiens (human).

References

PubMed References. Information about this virus have been posted on the web by a health support group .



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002    International Committee on Taxonomy of Viruses.    All rights reserved.


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