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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.026. Flaviviridae

Cite this publication as: ICTVdB Management (2006). 00.026. Flaviviridae. In: ICTVdB - The Universal Virus Database, version 3. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Classification

This is a description of a vertebrate virus at the family level.

ICTVdB Virus Code: 00.026. Virus accession number: 00026FAM. Obsolete virus code: 26.; superceded accession number: 26000000.
NCBI Taxon Identifier NCBI Taxonomy ID: 11050.

Name, Synonyms and Lineage

Synonym(s): Flavivirus group.

Morphology

Virions consist of an envelope and a nucleocapsid. Virus capsid is enveloped. Virions are spherical to pleomorphic measuring 40-60 nm in diameter. Surface projections are small spikes surrounded by a prominent fringe. Capsid/nucleocapsid is round and exhibits polyhedral symmetry. The core is isometric and has a diameter of 25-30 nm.

Capsids can be penetrated by stain and some appear dark in the center.

Physicochemical and Physical Properties

The molecular mass (Mr) of virions is 60 x 106. Virions have a buoyant density in CsCl of 1.07-1.24 g cm-3; sucrose of 1.1-1.23 g cm-3. The sedimentation coefficient is 140-200 S20w. Under in vitro conditions virions are stable in alkaline environment of pH 8. Virions are sensitive to treatment with heat, organic solvents, and detergents.

Nucleic Acid

The genome is not segmented and contains a single molecule of linear positive-sense, single-stranded RNA. The complete genome is 9500-12500 nucleotides long. The 5'-end of the genome has a methylated nucleotide cap, or genome-linked protein (VPg). The 3'-terminus has no poly (A) tract, or a poly (A) tract (in some strains of tick-borne encephalitis complex of flaviviruses).

GenBank records for nucleotide sequences; complete genome sequences.

Proteins

The viral genome encodes structural proteins and non-structural proteins. Virions consist of 3-4 structural protein(s).

Lipids

Lipids are present and located in the envelope. Virions are composed of 15-20% lipids by weight. The composition of viral lipids and host cell membranes are similar. The lipids are of host origin that derived from host cell membranes.

Genome Organization and Replication

By itself, genomic nucleic acid is infectious.

Replication cycle Features: the genome has 5' end encodes structural proteins which has a stem and loop structure. The non-structural proteins including protease, helicase and polymerase, are encode at the 3' end.

Antigenicity

Serological relationships between different members are found. Cross-reactivity is found. Cross-reactivity between species, but not genera.

Biological Properties

Natural Host

Virus infects during its life cycle arthropod and vertebrate hosts. Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Mollusca and Chordata.

Phylum Vertebrata
Subphylum Vertebrata.

Class Mammalia and Aves.

Class Mammalia Order Chiroptera and Primates;
Family Hominidae.
Virus infects Homo sapiens (human).

Transmission and Vector Relationships

Virus is transmitted by a vector, or not transmitted by a vector.

Vector Transmission:
Virus is transmitted by arthropods. Virus replicates in the vector.

Taxonomic Structure of the Family

00.026.0.01. Flavivirus
00.026.0.02. Pestivirus
00.026.0.03. Hepacivirus.

Unassigned Viruses

List of Unassigned Viruses in the Family.

Data Sources and Contributions

The description has been compiled from data in the ICTV Report presented by Wengler G, Bradley DW, Collett MS, Heinz FX, Schlesinger RW, Strauss JH.

References

The following generic references are cited in the most recent ICTV Report.

PubMed References. [Http]www.uq.edu.au/vdu/arbo.htm"> at Virology Down Under.



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002    International Committee on Taxonomy of Viruses.    All rights reserved.


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