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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.026.0.02. Pestivirus

Cite this publication as: ICTVdB Management (2006). 00.026.0.02. Pestivirus. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Classification

This is a description of a vertebrate virus at the genus level.

ICTVdB Virus Code: 00.026.0.02. Virus accession number: 026002GE. Obsolete virus code: 26.0.2.; superceded accession number: 26020000.
NCBI Taxon Identifier NCBI Taxonomy ID: 11095.

Name, Synonyms and Lineage

Synonym(s): Mucosal disease virus group. Virus is of the family 00.026. Flaviviridae.

Morphology

Virions consist of an envelope and a nucleocapsid. Virus capsid is enveloped. Virions are spherical to pleomorphic measuring 40-60 nm in diameter. Surface projections are distinctive spikes surrounded by a prominent fringe. Surface projections form ring-like subunits. Surface projections patterns are 10 nm in size. Capsid/nucleocapsid is round and exhibits polyhedral symmetry. The core is isometric.

Physicochemical and Physical Properties

The molecular mass (Mr) of virions is estimated to be 60 x 106. Virions have a buoyant density in CsCl of 1.1-1.15 g cm-3; sucrose of 1.12-1.13 g cm-3. The sedimentation coefficient is 140 S20w. The thermal inactivation point (TIP) is at 40°C. Under in vitro conditions virions are stable in alkaline environment of pH 8. Virions are sensitive to treatment with organic solvents and detergents.

Nucleic Acid

The genome is not segmented and contains a single molecule of linear positive-sense, single-stranded RNA. The complete genome is 12500 nucleotides long. The 5'-end of the genome does not have cap. The 3'-terminus has no poly (A) tract. Each virion contains usually a single copy of the genome (but sections of the genome can be duplicated in cytopathic bovine diarrhea virus (BvDV) resulting in genomic RNA sizes significantly larger than 12.5 kb).

GenBank records for nucleotide sequences; complete genome sequences.

Proteins

The viral genome encodes structural proteins and non-structural proteins. Virions consist of 4 structural protein(s).

Lipids

Lipids are present and located in the envelope (but no reports have described the lipids). The composition of viral lipids is not known.

Genome Organization and Replication

By itself, genomic nucleic acid is infectious.

Translation: The genome replicates in the cytoplasm.

Antigenicity

Antigenic determinants may be found on envelopes and correspond to each of the major structural glycoproteins; correspond to each of the major virion proteins gp48 and gp53. Although different antigenic determinants have different specificities, the antigenic determinants are in general type-specific and serogroup-specific. The type-specific antigenic determinants are involved in antibody mediated neutralization. Antigenic specificity of the virion can be determined by neutralization tests.

The virus is immunogenic. The virus serves as an efficient immunogen. The virus induces the formation of neutralizing antibodies. The virus serotype is determined by a serum neutralization test; using monoclonal antibodies.

Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Chordata.

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Artiodactyla;
Family Bovidae: Subfamily Bovinae; virus infects Genus Bos .

Transmission and Vector Relationships

Virus is not transmitted by a vector.

Histopathology: Virions are found in the cytoplasm.

Taxonomic Structure of the Genus

Type species 00.026.0.02.001. Bovine viral diarrhea virus 1 .

Species in the Genus

List of Species in the Genus.

Data Sources and Contributions

The description has been compiled from data in the ICTV Report presented by Wengler G, Bradley DW, Collett MS, Heinz FX, Schlesinger RW, Strauss JH.

References

The following generic references are cited in the most recent ICTV Report.

PubMed References.



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002    International Committee on Taxonomy of Viruses.    All rights reserved.


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