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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.026.0.01.051. West Nile virus

Cite this publication as: ICTVdB Management (2006). 00.026.0.01.051. West Nile virus. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Isolate Description

Isolate designation: Ntaya virus group.

Biocontainment Level

Distribution of this virus falls under quarantine restrictions. It is recommended to handle this virus at the biocontainment level BSL-3.

Classification

This is a description of a vertebrate virus at the species level.

ICTVdB Virus Code: 00.026.0.01.051. Virus accession number: 26001051. Obsolete virus code: 26.0.1.4.010; superceded accession number: 26014010.
NCBI Taxon Identifier NCBI Taxonomy ID: 11082.

Name, Synonyms and Lineage

Virus is an ICTV approved species of the genus 00.026.0.01. Flavivirus; family 00.026. Flaviviridae.

Virion Properties

Morphology

Virions consist of an envelope and a nucleocapsid. Virus capsid is enveloped. Virions are spherical and measure 40-50 nm in diameter. The envelope has surface projections. Surface projections are small spikes surrounded by a prominent fringe. Capsid/nucleocapsid is round and exhibits polyhedral symmetry. The core is isometric and has a diameter of 25-30 nm. The capsid shells of virions are composed of a single layer.

Nucleic Acid

The genome is monomeric; not segmented and contains a single molecule of linear, positive-sense, single-stranded RNA. The complete genome is 11000 nucleotides long. Sequence can be accessed from EBI-EMBL and GenBank. The RNA-1 is fully sequenced, complete sequence is 11000 nucleotides long. Sequence has the accession number [M12294]. The 5'-end of the genome has a methylated nucleotide cap. The 3'-terminus has no poly (A) tract.

GenBank records for nucleotide sequences; complete genome sequences.

Proteins

The viral genome encodes structural proteins and non-structural proteins.

Lipids

Lipids are present and located in the envelope. Virions are composed of 17% lipids by weight. The composition of viral lipids and host cell membranes are similar. The lipids are of host origin and are derived from host cell membranes.

Genome Organization and Replication

By itself, genomic nucleic acid is infectious.

Biological Properties

Natural Host

Virus infects during its life cycle arthropod and vertebrate hosts. Virus has an enzootic cycle and is transmitted from arthropod vector to birds and arthropod vector to an incidental incompetent host (dead end host). Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Arthropoda and Chordata.

Phylum Vertebrata
Subphylum Vertebrata.

Class Aves and Mammalia.

Class Mammalia Order Primates and Chiroptera;
Family Hominidae.
Virus infects Homo sapiens (human).

Transmission and Vector Relationships

Virus is transmitted by a vector.

Geographical Distribution

Geographical distribution of the virus is probably restricted. The virus spreads in Africa and North America. The virus is known to occur in temperate regions and subtropical regions; viral host lives under aerobic conditions. The virus occurs in Canada, Sudan, and the United States of America.

Ecology, Epidemiology and Control

Epidemiological surveillance activities are overseen by Health Canada: . A fact sheet on this virus is available from the [a href=" Centers for Disease Control and Prevention (CDC), National Center for Infectious Diseases (NCID) .
References for antiviral therapeutic agents: West Nile virus treatment in Veterinary Science Tomorrow (2005), Vol 5, May issue.

List of Strains and Isolates in the Species

00.026.0.01.051.04.204.005. Kunjin virus (strain MRM61C) NCBI TaxID [11078]; poly protein [P14335].
00.026.0.01.051.04.204.001. West Nile virus clone 33/G8; 34/F6NCBI TaxID [11082]; complete genome [M12294].

References

The following generic references are cited in the most recent ICTV Report.

PubMed References.

The description has been generated automatically from DELTA files.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002 International Committee on Taxonomy of Viruses. All rights reserved.

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