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00.011.0.02.019. Sin Nombre virus

Cite this publication as: ICTVdB Management (2006). 00.011.0.02.019. Sin Nombre virus. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Isolate Description

Isolation date: 03 September 1993.
Location: Ramah; New Mexico; the United States of America.

Host of Isolate and Habitat Details
Source of isolate: deer mouse; family Muridae, subfamily Sigmodontinae, Peromyscus maniculatus.

Collection and Isolation Details
Virus was isolated by Luanne Elliot. Special Pathogens Branch; Division of Viral and Rickettsial Diseases; NCID, U.S. Centers for Disease Control; Atlanta; Georgia; 30333; the United States of America; email: [mailto] tgk0@cdc.gov.

Reference to Isolation Report
Elliott LH, Ksiazek TG, Rollin PE, Spiropoulou CF, Morzunov S, Monroe M et al. Isolation of the causative agent of hantavirus pulmonary syndrome. Am J Trop Med.

Biocontainment Level

Distribution of this virus falls under quarantine restrictions. It is recommended to handle this virus at the biocontainment level BSL-3.

Classification

This is a description of a vertebrate virus at the species level.

ICTVdB Virus Code: 00.011.0.02.019. Virus accession number: 11002019.
NCBI Taxon Identifier NCBI Taxonomy ID: 37705.

Name, Synonyms and Lineage

The taxon has the accepted ICTV name (Sin Nombre virus).

Synonym(s): Muerto Canyon virus, Four Corners virus. ICTV approved acronym: SNV. Virus is an ICTV approved species of the genus 00.011.0.02. Hantavirus; of the family 00.011. Bunyaviridae; not assigned to an order.

Virion Properties

Symptoms in the host are well established and the causative agent is determined.

Distinct viral structures are visible in thin sections of infected tissue. Particles contain nucleic acid which is encapsidated. Size and shape of virus has been determined by electron microscopy.

Virion Properties

Morphology

Virions consist of an envelope and a nucleocapsid. During their life cycle, virions have an extracellular phase; occur in one phenotype only and are encapsidated during extracellular phase. Virus may be sequestered within inclusion bodies that are not occluded and typically contain one nucleocapsid. Virus capsid is enveloped by a double layer before leaving the host cell; spherical and measure 80-120 nm in diameter. The envelope surrounds three nucleocapsids; has surface projections. Surface projections are knob-shaped glycoproteins (GP) spikes that cover evenly the surface and are embedded in a lipid bilayer of 5 nm thickness. Surface projection proteins are glycosylated and antigenic formed by proteins G1 and G2 which exhibit hemagglutinin activity. Surface projections are in average 7 nm in diameter, or 5-10 nm in diameter (range). Host ribosomes are not seen inside the envelope. A regular capsid structure is present. Capsid/nucleocapsid is elongated with helical symmetry. The ribonucleocapsid is filamentous. The nucleocapsid is segmented.

Virion populations are comprised of particles of uniform size and only one species is recovered in preparations.

Nucleic Acid

The genome is monomeric; segmented and consists of three segments of circular, negative-sense and ambisense, single-stranded RNA; that forms a non-covalently closed circle. Minor species of non-genomic nucleic acid are not found in virions. The RNA-L is fully sequenced, complete sequence is 6562 nucleotides long. RNA-M;   is sequenced and complete sequence is about 3696 nucleotides long. RNA-S is sequenced and complete sequence is about 2059 nucleotides long. The 5'-terminus has no poly (C) tract. The multipartite genome is found in one type of particle only. Each virion contains a single copy of the genome.

GenBank records for nucleotide sequences; complete genome sequences.

Polyamines

Polyamines associated with the virion are not present.

Coding Strategy of Segment 1: Sequence has no gene blocks.

Translation: Replication does not involve a reverse transcription step.

Virions are not dependent on a helper virus for replication.

Release: The outer envelope acquired by budding.

Antigenicity

The virus is immunogenic.

Biological Properties

Natural Host

Virus infects during its life cycle a variety of vertebrate hosts. Virus has an enzootic cycle and is transmitted from rodents to humans. Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Chordata.

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Rodentia and Primates;
Family Hominidae.
Virus infects Homo sapiens (human, Suborder Sciurognathi; Family Muridae; Subfamily Sigmodontinae; virus infects Genus Peromyscus maniculatus.

Severity and Occurrence of Disease

Host: Infection is apparent.

Transmission and Vector Relationships

Virus is transmitted by a vector.

References

The following generic references are cited in the most recent ICTV Report.

PubMed References.
A description of the virus is found at the U.S. Centers for Disease Control and Prevention (CDC), National Center for Infectious Diseases (NCID, .

Contributor

Data have been submitted online to ICTVdB by
Charles H.; Calisher;
AIDL, Department of Microbiology, Immunology, and Pathology;
Colorado State University;
Foothills Campus;
Fort Collins; Colorado; 80523;
U.S.A.;
Tel: + + 001-970-491-2987;
Fax: + + 001-970-491-8323;
email: [mailto] calisher@cybercell.net. Involved in the isolation of the virus was also Thomas G. Ksiazek; NCID, U.S. Centers for Disease Control [[mailto:]tgk0@cdc.gov]; Pierre Rollin; NCID, U.S. Centers for Disease Control [[mailto:]pyr3@cdc.gov]; John Krebs; NCID, U.S. Centers for Disease Control [[mailto:]jok2@cdc.gov].



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002    International Committee on Taxonomy of Viruses.    All rights reserved.


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