Descriptions are
generated automatically from the ICTVdB database including links. Some
descriptions are only very basic and links may point to documents that are not
yet published on the Web.
00.011.0.01.016. California
encephalitis virus
Cite this publication as: ICTVdB
Management (2006). 00.011.0.01.016. California encephalitis virus. In: ICTVdB
- The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed),
Columbia University, New York, USA
Cite this site as: ICTVdB - The
Universal Virus Database, version 4.
http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/
Biocontainment Level
Distribution of this virus
falls under quarantine restrictions. It is recommended to handle this virus at
the biocontainment level BSL-2.
This is a description of an
invertebrate and vertebrate virus at the species
level.
ICTVdB Virus Code: 00.011.0.01.016. Virus accession number:
11010016. Obsolete virus code: 11.0.1.07; superceded accession number: 11010700.
NCBI Taxon Identifier NCBI Taxonomy ID:
35305.
Name, Synonyms and Lineage
The taxon has the
accepted ICTV name.
Virus is an ICTV approved species of the genus
00.011.0.01.
Orthobunyavirus; of the family
00.011.
Bunyaviridae; not assigned to an order.
Symptoms in the host are
well established and the causative agent is determined.
Distinct viral structures are visible in thin sections of infected tissue.
Particles contain nucleic acid which is
encapsidated.
Virions consist of an envelope and a nucleocapsid. During
their life cycle, virions have an extracellular phase; occur in one phenotype
only and are encapsidated during extracellular phase. Virus may
be sequestered within inclusion bodies that are not occluded and
typically contain one nucleocapsid. Virus capsid is enveloped by a
single layer envelope. Virions are spherical to pleomorphic. Have no
protrusions. Virions measure (80-)100(-120) nm in
diameter. The envelope surrounds three nucleocapsids; has surface projections.
Surface projections are distinctive spikes
covering evenly the surface which are embedded in a lipid bilayer
that is 5 nm thick. Surface projections are 5-10 nm long. Host
ribosomes are not seen inside the envelope. A regular capsid structure is
present. Capsid/nucleocapsid is elongated with helical
symmetry. The ribonucleocapsid is filamentous with a length of
200-3000 nm (depending on arrangement) and a width of 2-2.5 nm. The
nucleocapsid is not segmented. Nucleocapsids are circular.
Virion populations are comprised of particles of uniform size
and only one species is recovered in preparations.
Electron micrograph of 00.011.0.01.016.07.006. La Crosse
virus by A.F. Murphy, Veterinary Medicine, UC Davis, CA.
Additional electron micrographs are found at Wadsworth
.
The Mr
of the genome constitutes 1-2% of the virion by weight. The genome is
monomeric; segmented and consists of three segments of circular,
negative-sense and ambisense, single-stranded
RNA; that forms a non-covalently closed circle. Minor species of
non-genomic nucleic acid are not found in virions. The complete genome is
12300-12450 nucleotides long. The RNA-L is is about 6980 nucleotides long.
RNA-M is sequenced and complete
sequence is about 4450-4540 nucleotides long. RNA-S is sequenced, but
only an estimate is given, complete sequence is 850-990
nucleotides long. The genome has terminally redundant sequences. The terminally
redundant sequences have reiterated terminal sequences. The genome sequence is
repeated at both ends. Terminal nucleotides are base-paired, forming
non-covalently closed, circular RNAs. Nucleotide sequences at the
3'-terminus are complementary to the 5' end and form a panhandle. The
5'-terminal sequence has conserved regions and repeats complementary to the
3'-terminus; terminal repeats at the 5'-end are 8-11 nucleotides
long. The 5'-terminus has no poly (C) tract. The 3'-terminus has
conserved nucleotide sequences; of 11 nucleotides in length; at the 3' end
UCAUCACAUGA...; sequence has 11 nucleotides in length; in each gene segment. The
multipartite genome is found in one type of particle only. Each virion contains
a single copy of the genome.
GenBank records for
nucleotide sequences;
complete genome sequences.
Proteins
constitute about over 50% of the particle weight.
The viral genome encodes structural proteins and non-structural proteins.
Lipids are
present and located in the envelope. Virions are composed of
20-30% lipids by weight. The composition of viral lipids is known. The
composition of viral lipids and host cell membranes are similar. The lipids are
of host origin and are derived from plasma membranes. Viral
membranes include phospholipids, sterols, fatty acids, and glycolipids. Lipids
are not essential for infectivity.
Polyamines
Polyamines associated with the virion are not
present.
Coding Strategy of Segment 1: Sequence has no
gene blocks.
Translation: Replication does not
involve a reverse transcription step.
Virions are not dependent on a helper virus for replication.
Release: The outer envelope acquired
by budding. The outer envelope lipids are derived from cellular Golgi membranes,
or cell surface membranes (occasionally).
The virus is immunogenic.
Natural Host
Virus infects during its life cycle arthropod and vertebrate hosts. Domain
Viral hosts belong to the Domain Eucarya.
Domain Eucarya
Kingdom Animalia.
Kingdom Animalia
Phylum Chordata.
Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.
Class Mammalia
Order Primates;
Family
Hominidae.
Virus infects Homo sapiens (human).
Severity and Occurrence of
Disease
Host: Infection is apparent.
Virus is transmitted by a vector.
List of Strains and
Isolates in the Species
00.011.0.01.016.07.002. CEV BFS-283 strain
00.011.0.01.016.07.016. CEV E6071 strain
00.011.0.01.016.07.003. Inkoo strain
00.011.0.01.016.07.003.001. Inkoo strain, KN 3641 isolate
00.011.0.01.016.07.003.002. Inkoo strain, SWAR83-161 isolate
00.011.0.01.016.07.004. Jamestown Canyon strain
00.011.0.01.016.07.004.001. Jamestown Canyon strain, 61V2235 isolate
00.011.0.01.016.07.004.002. Jamestown Canyon strain, DAV28 isolate
00.011.0.01.016.07.015. Jerry Slough strain
00.011.0.01.016.07.015.001. Jerry Slough strain, BFS4474 isolate
00.011.0.01.016.07.005. Keystone strain
00.011.0.01.016.07.005.001. Keystone strain, C14031-33 isolate
00.011.0.01.016.07.005.002. Keystone strain, B64-5587.05 isolate
00.011.0.01.016.07.006. La Crosse virus
00.011.0.01.016.07.006.001. La Crosse virus, original isolate
00.011.0.01.016.07.006.002. La Crosse virus, Human78 isolate
00.011.0.01.016.07.014. Lumbo strain
00.011.0.01.016.07.014.001. Lumbo strain, isolate SA Ar 1881
00.011.0.01.016.07.014.002. Lumbo strain, unspecified isolate
00.011.0.01.016.07.007. Melao strain
00.011.0.01.016.07.007.001. Melao strain, isolate TRVL9375
00.011.0.01.016.07.017. Morro Bay strain
00.011.0.01.016.07.017.001. Morro Bay strain, DAV-457 isolate
00.011.0.01.016.07.008. San Angelo strain
00.011.0.01.016.07.008.001. San Angelo strain, unspecified isolate
00.011.0.01.016.07.009. Serra do Navio strain
00.011.0.01.016.07.010. Snowshoe hare strain
00.011.0.01.016.07.010.001. Snowshoe hare strain, unspecified isolate
00.011.0.01.016.07.011. South River strain
00.011.0.01.016.07.011.001. South River strain, NJO 94 F isolate
00.011.0.01.016.07.012. Tahyna strain
00.011.0.01.016.07.012.001. Tahyna strain, isolate 92
00.011.0.01.016.07.012.002. Tahyna strain, isolate 181-57
00.011.0.01.016.07.013. Trivittatus strain
00.011.0.01.016.07.013. Trivittatus Prototype strain
00.011.0.01.016.07.013.001. Trivittatus strain, isolate 933
00.011.0.01.016.07.013.002. Trivittatus strain, Eklund isolate.
The
following generic references are cited in the most recent ICTV Report.
PubMed References.
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