[Home] [ICTV Taxonomy - Index of Viruses] [Virus Descriptions] [Character List] [Picture Gallery]
[Tutorial] [Online Data Retrieval & Identification] [Virus Isolate Registration & Submission] [Search]
Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.011.0.01.016.07.006.001. La Crosse virus, original isolate

Cite this publication as: ICTVdB Management (2006). 00.011.0.01.016.07.006.001. La Crosse virus, original isolate. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Isolate Description

Isolate designation: original.
Isolation date: 07 August 1964.
Location: LaCrosse; Wisconsin; the United States of America.

Host of Isolate and Habitat Details
Source of isolate: human.

Collection and Isolation Details
Virus was isolated by Dr Wayne Thompson. State Laboratory of Hygiene; Madison; Wisconsin; the United States of America.

Reference to Isolation Report
Thompson W.H., Kalfayan B., Anslow R.O. (1965). Isolation of California encephalitis group virus from a fatal human illness. Am. J. Epidemiol. 81:245-253.

Depositories and Collections

The isolate has been deposited at the American Type Culture Collection (ATCC) and a culture collection (World Centre for Arbovirus Reference and Research, UTMB, Galveston,

Texas, U.S.A.) and is listed in the ATCC catalogue with the reference number [VR-744].

Biocontainment Level

Distribution of this virus falls under quarantine restrictions. It is recommended to handle this virus at the biocontainment level BSL-2.

Classification

This is a description of an invertebrate and vertebrate virus at the isolate level.

ICTVdB Virus Code: 00.011.0.01.016.07.006.001. Virus accession number: 11016161.
NCBI Taxonomy Identifier Taxon ID: 11577.

Name, Synonyms and Lineage

Virus is assigned to strain La Crosse virus of the genus 00.011.0.01. Orthobunyavirus; of the family 00.011. Bunyaviridae; not assigned to an order.

Virion Properties

Symptoms in the host are well established and the causative agent is determined.

Distinct viral structures are visible in thin sections of infected tissue. Particles contain nucleic acid which is encapsidated.

Virion Properties

Morphology

Virions consist of an envelope, a nucleocapsid, and a polymerase complex. During their life cycle, virions have an extracellular phase, occur in one phenotype only, and are encapsidated during extracellular phase. Virus may be sequestered within inclusion bodies that are not occluded and typically contain one nucleocapsid. Virus capsid is enveloped by a double layer envelope. Virions are spherical. Virions measure 100 nm in diameter. The envelope surrounds three nucleocapsids; has surface projections. Surface projections are distinctive. A regular capsid structure is present. Capsid/nucleocapsid is elongated with helical symmetry. The ribonucleocapsid is filamentous. Nucleocapsids are circular.

Virion populations are comprised of particles of uniform size and only one species is recovered in preparations.

Nucleic Acid

The genome is monomeric; segmented and consists of three segments of circular, negative-sense and ambisense, single-stranded RNA; that forms a non-covalently closed circle. Minor species of non-genomic nucleic acid are not found in virions. Sequence can be accessed from EBI-EMBL and GenBank. The RNA-L is fully sequenced. Complete sequence is 6980 nucleotides long. Sequence has the accession number [U12396]. RNA-M is fully sequenced, complete sequence is 4526 nucleotides long and has the accession number [D00202]. RNA-S is fully sequenced, complete sequence is 984 nucleotides long and has the accession number [K00610]. The multipartite genome is found in one type of particle only. Each virion contains a single copy of the genome.

Reference to nucleotide sequence in PubMed: nucleotide sequences; complete genome sequences.

Polyamines

Polyamines associated with the virion are not present.

Coding Strategy of Segment 1: Sequence has no gene blocks.

Translation: Replication does not involve a reverse transcription step.

Virions are not dependent on a helper virus for replication.

Antigenicity

The virus is immunogenic.

Biological Properties

Natural Host

Virus infects during its life cycle arthropod and vertebrate hosts. Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Chordata.

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Primates;
Family Hominidae.
Virus infects Homo sapiens (human).

Severity and Occurrence of Disease

Host: Infection is apparent.

Transmission and Vector Relationships

Virus is transmitted by a vector.

Host:
Experimental host is susceptible to infection suckling Mus musculus. Experimentally infected hosts mainly show symptoms of death.

References

PubMed References.

Contributor

Data have been submitted online to ICTVdB by
Charles H.; Calisher;
AIDL, Department of Microbiology, Immunology, and Pathology;
Colorado State University;
Foothills Campus;
Fort Collins; Colorado; 80523;
U.S.A.;
Tel: + + 001-970-491-2987;
Fax: + + 001-970-491-8323;
email: [mailto] calisher@cybercell.net. Involved in the isolation of the virus was also Dr B.F. Kalfayan; Department of Pathology, Lutheran Hospital, Madison, Wisconsin.



Limit search to: Title & Body Title Document Path
Show Reverse Sort

DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002    International Committee on Taxonomy of Viruses.    All rights reserved.


Additional access points to virus species lists, descriptions and images on the web:

Species catalogue                     iSpecies.org - a species search engine           a species search engine

Google Analytics      Google Analytics: activity view