Table S2. Distribution of GGDEF, EAL, HD-GYP and PilZ domains in prokaryotesa

A web supplement to the paper by Dorit Amikam and Michael Galperin "PilZ domain is part of the bacterial c-di-GMP binding protein",
published in Bioinformatics (2006) 22: 3-6. Abstract. Full text (PDF, open access).

Actinobacteria
Phylum
GenBank entry
Proteins
GGDEF
EAL
HD-GYP
PilZ
Correlation
Bifidobacterium longum
Actino
AE014295
1727
0
0
0
0
Yes
Corynebacterium diphtheriae
Actino
BX248353
2272
0
0
0
0
Yes
Corynebacterium efficiens
Actino
BA000035
2950
0
0
0
0
Yes
Corynebacterium glutamicum
Actino
BA000036
2993
1
1
0
0
No
Leifsonia xyli
Actino
AE016822
2030
0
0
0
0
Yes
Mycobacterium avium
Actino
AE016958
4350
4*
3
1
0
No
Mycobacterium bovis
Actino
BX248333
3920
1
2
0
0
No
Mycobacterium leprae
Actino
AL450380
1605
3
2
0
0
No
Mycobacterium tuberculosis
Actino
AL123456
3927
1
2
0
0
No
Nocardia farcinica
Actino
AP006618
5924
8
2
0
0
No
Propionibacterium acnes
Actino
AE017283
2297
0
0
0
0
Yes
Streptomyces avermitilis
Actino
BA000030
7671
7*
5
1
0
No
Streptomyces coelicolor
Actino
AL645882
8154
7*
5
1
0
No
Symbiobacterium thermophilum
Actino
AP006840
3337
9
3
4
1
Yes
Tropheryma whipplei
Actino
BX072543
783
0
0
0
0
Yes
Cyanobacteria
Phylum
GenBank entry
Proteins
GGDEF
EAL
HD-GYP
PilZ
Correlation
Gloeobacter violaceus
Cyano
BA000045
4430
1
0
1
1
Yes
Nostoc sp. PCC 7120
Cyano
BA000019
6055
14
7
2
0
No
Prochlorococcus marinus CCMP1375
Cyano
AE017126
1882
0
0
0
0
Yes
Synechococcus elongatus PCC 6301
Cyano
AP008231
2525
17
9
2
2
Yes
Synechococcus sp. WH 8102
Cyano
BX548020
2517
0
0
0
0
Yes
Synechocystis sp. PCC 6803
Cyano
BA000022
3166
22
13
2
0
No
Thermosynechococcus elongatus
Cyano
BA000039
2475
9*
5
1
3
Yes
Alpha-proteobacteria
Phylum
GenBank entry
Proteins
GGDEF
EAL
HD-GYP
PilZ
Correlation
Agrobacterium tumefaciens
Alpha
AE008688
5402
27*
14*
1
3
Yes
Anaplasma marginale
Alpha
CP000030
949
1
0
0
0
No
Bartonella henselae
Alpha
BX897699
1488
1
1
0
0
No
Bartonella quintana
Alpha
BX897700
1142
1
1
0
0
No
Bradyrhizobium japonicum
Alpha
BA000040
8317
35
27
3
13
Yes
Brucella melitensis
Alpha
AE008917
3198
9
5
0
0
No
Brucella suis
Alpha
AE014291
3271
8
5
0
0
No
Caulobacter crescentus
Alpha
AE005673
3737
10*
10
0
2
Yes
Mesorhizobium loti
Alpha
BA000012
7275
32
18
1
2
Yes
Nitrobacter winogradskyi
Alpha
CP000115
3122
8
6
1
4
Yes
Pelagibacter ubique
Alpha
CP000084
1354
0
0
0
0
Yes
Rhodopseudomonas palustris
Alpha
BX571963
4813
36
18
2
8
Yes
Rickettsia conorii
Alpha
AE006914
1374
1
1
0
0
No
Rickettsia prowazekii
Alpha
AJ235269
835
1
1
0
0
No
Rickettsia typhi
Alpha
AE017197
838
1
1
0
0
No
Silicibacter pomeroyi
Alpha
CP000031
4252
5
2
0
0
No
Sinorhizobium meliloti
Alpha
AL591688
6205
17*
13*
0
2
Yes
Wolbachia endosymbiont of Drosophila
Alpha
AE017196
1195
1
0
0
0
No
Zymomonas mobilis
Alpha
AE008692
1998
4
3
0
1
Yes
Beta-proteobacteria
Phylum
GenBank entry
Proteins
GGDEF
EAL
HD-GYP
PilZ
Correlation
Azoarcus sp. EbN1
Beta
CR555306
4603
26
23
5
1
Yes
Bordetella bronchiseptica
Beta
BX470250
4994
15
9
2
1
Yes
Bordetella parapertussis
Beta
BX470249
4185
13
9
2
1
Yes
Bordetella pertussis
Beta
BX470248
3436
7
3
1
1
Yes
Burkholderia mallei
Beta
CP000011
4764
8
8
2
3
Yes
Burkholderia pseudomallei
Beta
BX571965
5728
10
11
2
3
Yes
Chromobacterium violaceum
Beta
AE016825
4407
43
26
11
4
Yes
Neisseria gonorrhoeae
Beta
AE004969
2002
0
0
0
0
Yes
Neisseria meningitidis
Beta
AE002098
2079
0
0
0
0
Yes
Nitrosomonas europaea
Beta
AL954747
2461
6
9
0
1
Yes
Ralstonia solanacearum
Beta
AL646052
5116
22*
14
2
2
Yes
Gamma-proteobacteria
Phylum
GenBank entry
Proteins
GGDEF
EAL
HD-GYP
PilZ
Correlation
Acinetobacter sp. ADP1
Gamma
CR543861
3325
10
4
0
1
Yes
Buchnera aphidicola str. APS
Gamma
BA000003
574
0
0
0
0
Yes
Candidatus Blochmannia floridanus
Gamma
BX248583
583
0
0
0
0
Yes
Coxiella burnetii
Gamma
AE016828
2046
0*
0
0
0
Yes
Erwinia carotovora
Gamma
BX950851
4472
16*
11
0
2
Yes
Escherichia coli K12
Gamma
U00096
4242
19
17
0
2
Yes
Escherichia coli O157:H7
Gamma
BA000007
5253
19
14
0
2
Yes
Francisella tularensis
Gamma
AJ749949
1804
0
0
0
0*
Yes
Haemophilus ducreyi
Gamma
AE017143
1717
0
0
0
0
Yes
Haemophilus influenzae
Gamma
L42023
1711
0
0
0
0
Yes
Idiomarina loihiensis
Gamma
AE017340
2640
33
20
1
6
Yes
Legionella pneumophila
Gamma
AE017354
2942
19
14
0
2
Yes
Mannheimia succiniciproducens
Gamma
AE016827
2384
0
0
0
0
Yes
Methylococcus capsulatus
Gamma
AE017282
2959
16
12
1
1
Yes
Pasteurella multocida
Gamma
AE004439
2015
0
0
0
0
Yes
Photobacterium profundum
Gamma
CR354531
5480
32*
16
2
5
Yes
Photorhabdus luminescens
Gamma
BX470251
4683
0
0
0
0
Yes
Pseudomonas aeruginosa
Gamma
AE004091
5567
33
21
3
8
Yes
Pseudomonas putida
Gamma
AE015451
5350
36
21
2
6
Yes
Pseudomonas syringae
Gamma
AE016853
5608
35
21
1
7
Yes
Salmonella enterica serovar Paratyphi
Gamma
CP000026
4093
13
15
0
2
Yes
Salmonella enterica serovar Typhi
Gamma
AL513382
4758
12
16
0
2
Yes
Salmonella typhimurium LT2
Gamma
AE006468
4527
12
15
0
2
Yes
Shewanella oneidensis
Gamma
AE014299
4467
52*
27*
9
4
Yes
Shigella flexneri
Gamma
AE005674
4441
8
8
0
1
Yes
Vibrio cholerae
Gamma
AE003852
3835
41
22
9
4
Yes
Vibrio parahaemolyticus
Gamma
BA000031
4832
44*
29
5
4
Yes
Vibrio vulnificus
Gamma
AE016795
5024
66
33
13
5
Yes
Wigglesworthia glossinidia
Gamma
BA000021
617
0
0
0
0
Yes
Xanthomonas axonopodis
Gamma
AE008923
4427
30
14
3
4
Yes
Xanthomonas campestris
Gamma
AE008922
4181
31
14
3
4
Yes
Xylella fastidiosa 9a5c
Gamma
AE003849
2832
3
3
1
2
Yes
Yersinia pestis
Gamma
AL590842
4067
5
6
0
1
Yes
Yersinia pseudotuberculosis
Gamma
BX936398
4038
6
6
1
1
Yes
Delta-proteobacteria
Phylum
GenBank entry
Proteins
GGDEF
EAL
HD-GYP
PilZ
Correlation
Bdellovibrio bacteriovorus
Delta
BX842601
3587
5
1
6
15
Yes
Desulfotalea psychrophila
Delta
CR522870
3236
23
4
10
8
Yes
Desulfovibrio vulgaris
Delta
AE017285
3531
26
10
14
7
Yes
Geobacter sulfurreducens
Delta
AE017180
3446
28
9
10
10
Yes
Epsilon-proteobacteria
Phylum
GenBank entry
Proteins
GGDEF
EAL
HD-GYP
PilZ
Correlation
Wolinella succinogenes
Epsilon
BX571656
2044
21
13*
2
1
Yes
Helicobacter hepaticus
Epsilon
AE017125
1875
1
0
0
0
No
Campylobacter jejuni
Epsilon
AL111168
1634
1
0
0
0
No
Helicobacter pylori
Epsilon
AE000511
1576
0
0
0
0
Yes
Firmicutes
Phylum
GenBank entry
Proteins
GGDEF
EAL
HD-GYP
PilZ
Correlation
Bacillus anthracis str. Ames
Firmi
AE016879
5311
9*
7
1
0
No
Bacillus cereus ATCC 14579
Firmi
AE016877
5255
7*
5
0
0
No
Bacillus halodurans
Firmi
BA000004
4066
4*
2
2
2
Yes
Bacillus licheniformis
Firmi
AE017333
4196
4*
2
0
2
Yes
Bacillus subtilis
Firmi
AL009126
4105
4*
3
0
1
Yes
Bacillus thuringiensis
Firmi
AE017355
5117
9*
7
1
0
No
Clostridium acetobutylicum
Firmi
AE001437
3848
10*
4
9
5
Yes
Clostridium perfringens
Firmi
BA000016
2723
6*
3
1
0
No
Clostridium tetani
Firmi
AE015927
2373
6*
1
1
1
Yes
Enterococcus faecalis
Firmi
AE016830
3267
0*
0
0
0
Yes
Geobacillus kaustophilus
Firmi
BA000043
3540
8*
5
3
2
Yes
Lactobacillus johnsonii
Firmi
AE017198
1821
0*
0
0
0
Yes
Lactobacillus plantarum
Firmi
AL935263
3059
3*
5
0
0
No
Lactococcus lactis
Firmi
AE005176
2321
0*
0
0
0
Yes
Listeria innocua
Firmi
AL592022
2968
3*
3
0
0
No
Listeria monocytogenes
Firmi
AL591824
2846
3*
3
0
0
No
Mesoplasma florum
Firmi
AE017263
682
0
0
0
0
Yes
Mycoplasma gallisepticum
Firmi
AE015450
726
0
0
0
0
Yes
Mycoplasma genitalium
Firmi
L43967
484
0
0
0
0
Yes
Mycoplasma hyopneumoniae
Firmi
AE017332
691
0*
0
0
0
Yes
Mycoplasma mobile
Firmi
AE017308
633
0*
0
0
0
Yes
Mycoplasma mycoides
Firmi
BX293980
1016
0
0
0
0
Yes
Mycoplasma penetrans
Firmi
BA000026
1037
0
0
0
0
Yes
Mycoplasma pneumoniae
Firmi
U00089
677
0
0
0
0
Yes
Mycoplasma pulmonis
Firmi
AL445566
782
0*
0
0
0
Yes
Oceanobacillus iheyensis
Firmi
BA000028
3500
3*
2
2
1
Yes
Onion yellows phytoplasma
Firmi
AP006628
754
0*
0
0
0
Yes
Staphylococcus aureus N315
Firmi
BA000018
2624
1*
0
0
0
No
Staphylococcus epidermidis
Firmi
AE015929
2419
1*
0
0
0
No
Streptococcus agalactiae
Firmi
AE009948
2124
0*
0
0
0
Yes
Streptococcus mutans
Firmi
AE014133
1960
0*
0
0
0
Yes
Streptococcus pneumoniae
Firmi
AE005672
2094
0*
0
0
0
Yes
Streptococcus pyogenes M1 GAS
Firmi
AE004092
1697
0*
0
0
0
Yes
Streptococcus thermophilus
Firmi
CP000024
1915
0*
0
0
0
Yes
Thermoanaerobacter tengcongensis
Firmi
AE008691
2588
6*
1
6
1
Yes
Ureaplasma parvum
Firmi
AF222894
614
0
0
0
0
Yes
Other bacterial phyla
Phylum
GenBank entry
Proteins
GGDEF
EAL
HD-GYP
PilZ
Correlation
Rhodopirellula baltica
Other
BX119912
7325
9*
3
6
1
Yes
Bacteroides thetaiotaomicron
Other
AE015928
4778
0
0
0
0
Yes
Bacteroides fragilis
Other
AP006841
4625
0
0
0
0
Yes
Deinococcus radiodurans
Other
AE000513
3184
16
5
4
0
No
Chlorobium tepidum
Other
AE006470
2252
1
0
0
0
No
Thermus thermophilus
Other
AE017221
2210
6*
2
5
0
No
Fusobacterium nucleatum
Other
AE009951
2066
0
0
0
0
Yes
Parachlamydia sp. UWE25
Other
BX908798
2031
0
0
0
0
Yes
Porphyromonas gingivalis
Other
AE015924
1909
0
0
0
0
Yes
Thermotoga maritima
Other
AE000512
1858
9*
0
10
1
Yes
Aquifex aeolicus
Other
AE000657
1560
11*
6*
1
5
Yes
Chlamydophila pneumoniae CWL029
Other
AE001363
1054
0
0
0
0
Yes
Chlamydophila caviae
Other
AE015925
1005
0
0
0
0
Yes
Chlamydia muridarum
Other
AE002160
904
0
0
0
0
Yes
Chlamydia trachomatis
Other
AE001273
895
0
0
0
0
Yes
Spirochaetes
Phylum
GenBank entry
Proteins
GGDEF
EAL
HD-GYP
PilZ
Correlation
Borrelia burgdorferi
Spiro
AE001115
1639
1
1
1
1
Yes
Borrelia garinii
Spiro
CP000013
932
1
1
1
1
Yes
Leptospira interrogans
Spiro
AE010300
4727
16
8
2
2
Yes
Treponema denticola
Spiro
AE017226
2767
9
2
4
2
Yes
Treponema pallidum
Spiro
AE000520
1036
1*
0
3
1
Yes
Archaea
Phylum
GenBank entry
Proteins
GGDEF
EAL
HD-GYP
PilZ
Correlation
Methanosarcina acetivorans
Archaea
AE010299
4540
0
0
0
0
Yes
Haloarcula marismortui
Archaea
AY596297
4240
0
0
0
0
Yes
Methanosarcina mazei
Archaea
AE008384
3371
0
0
0
0
Yes
Sulfolobus solfataricus
Archaea
AE006641
2977
0
0
0
0
Yes
Sulfolobus tokodaii
Archaea
BA000023
2825
0
0
0
0
Yes
Halobacterium salinarum
Archaea
AE004437
2622
0
0
0
0
Yes
Pyrobaculum aerophilum
Archaea
AE009441
2605
0
0
0
0
Yes
Archaeoglobus fulgidus
Archaea
AE000782
2420
0
0
0
0
Yes
Pyrococcus furiosus
Archaea
AE009950
2125
0
0
0
0
Yes
Pyrococcus horikoshii
Archaea
BA000001
1955
0
0
0
0
Yes
Pyrococcus abyssi
Archaea
AL096836
1896
0
0
0
0
Yes
Methanothermobacter thermautotrophicus
Archaea
AE000666
1873
0
0
0
0
Yes
Aeropyrum pernix
Archaea
BA000002
1841
0
0
0
0
Yes
Methanocaldococcus jannaschii
Archaea
L77117
1786
0
0
0
0
Yes
Methanococcus maripaludis
Archaea
BX950229
1722
0
0
0
0
Yes
Methanopyrus kandleri
Archaea
AE009439
1687
0*
0
0
0
Yes
Picrophilus torridus
Archaea
AE017261
1535
0
0
0
0
Yes
Thermoplasma volcanium
Archaea
BA000011
1499
0
0
0
0
Yes
Thermoplasma acidophilum
Archaea
AL139299
1481
0
0
0
0
Yes
Nanoarchaeum equitans
Archaea
AE017199
535
0
0
0
0
Yes

a The numbers in bold indicate the total number of proteins containing domains of each kind. Proteins containing both GGDEF and EAL domains are counted in both columns. Non-zero numbers are linked to protein lists, which are further linked to RefSeq and UniProt entries, BLink outputs, and CDD and Pfam domain architectures. Numbers with asterisks indicate the presence of proteins with highly divergent or truncated domains, not included in the total count but listed at the end of the each protein list. The 'Correlation' column shows whether the presence of diguanylate cyclase (GGDEF) domains is balanced by the presence of c-di-GMP-specific phosphodiesterase (EAL) or predicted phosphodiesterase (HD-GYP) domains and predicted c-di-GMP-binding (PilZ) domains.


Please send corrections, questions and comments to Michael Galperin