A WWW supplement to the article by Michael Y. Galperin, D. Roland Walker and Eugene V. Koonin
"Analogous enzymes: Independent inventions in enzyme evolution", published in Genome Research, vol. 8, pp. 779-790. Free full text
(The paper and the table are to be updated by the end of 2007)

No.	Taxonomic representation				PDB hits	Homologous enzymes with different enzymatic activities (EC No., example); comments
	Gram-negative bacteria	Gram-positive bacteria	Archaea	Eukaryotes
1. Alcohol dehydrogenase NAD-dependent (EC 1.1.1.1)
1	Ec:ADHE_ECOLI Hi:- Hp:HP0056 Sy:sll1561	Bsub:GbsB Mgen:- Mpne: Mtub:5271086 ot:ADHE_CLOAB	Mjan:MJ1411 Mthe:MTH984 Aful:AF0024 Sulf:	Yeast:ADH4_YEAST Celeg:121630 Human:435487 Plant:P5CS_VIGAC ot:U04863
2	Ec:ADHP_ECOLI   Hi:ADH3_HAEIN Hp:HP1104 Sy:sll0990	Bsub:GutB Mgen:- Mgen:- Mpne:MP278 Mtub: ot:ADH3_BACST	Mjan:-- Mthe:- Aful:AF2101 Sulf:ADH1_SULSO	Yeast:FADH_YEAST Celeg:U18781 Human:ADHA_HUMAN Plant:ADH_ARATH ot:ADH_ANAPL	1HDZ 1DEH 2OHX 1HDX 1HDY	Zn-containing dehydrogenases:   Formaldehyde dehydrogenase (EC 1.2.1.1, FADH_YEAST)   Rossmann fold
3	Ec:FABG_ECOLI Hi:FABG_HAEIN Hp:HP0557 Sy:slr0886	Bsub:FabG Mgen:- Mpne:- Mtub: ot:ACT3_STRCO	Mjan:-- Mthe:- Aful:- Sulf:	Yeast:YNL202w Celeg:1171506 Human:PGDH_HUMAN  Plant:S57614 ot:ADHR_DROGU		Short-chain dehydrogenases:   3-keto-ACP reductase (EC 1.1.1.100, FABG_ECOLI),   glucose dehydrogenase (EC 1.1.1.47, DHG_BACSU)
2. Alcohol dehydrogenase NADP-dependent (EC 1.1.1.2)
4	Ec:TDH_ECOLI Hi:ADH3_HAEIN Hp:HP2383R Sy:sll0990	Bsub:AdhB Mgen:- Mpne:MP278 Mtub:2225965 ot:ADH_THEBR ot:ADH_CLOBE	Mjan:-- Mthe:- Aful:AF2101 Sulf:ADH3_SULSO	Yeast:DHSO_YEAST Celeg:R04B5.5 Human:DHSO_HUMAN Plant:ADH1_PEA ot:ADH1_ENTHI	1DEH 1HDZ 1TEH 1HTB 1HUD 1SDG 2OHX	Zn-containing dehydrogenases   Rossmann fold
5	Ec:YAFB_ECOLI Hi:- Hp:HP1193 Sy:slr0942	Bsub:YtbE Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast:YHQ4_YEAST Celeg:T08H10.1 Human:ALDX_HUMAN Plant:ALDR_HORVU	2ALR 1DLA 1ADS 1ABN 1FRB 2ACU	Aldo/keto reductase family
3. L-lactate dehydrogenase (EC 1.1.1.27)
6	Ec:YBIC_ECOLI Hi:YIAK_HAEIN Hp:- Sy:- ot: LDH_ALCEU	Bsub:YjmC Mgen:- Mpne:- Mtub:	Mjan:MDH_METJA Mthe:MTH1205 Aful:- Sulf: ot:MDH_METFE	Yeast:- Celeg: Human: Plant:		Archaebacterial malate dehydrogenase family   Malate dehydrogenase (EC 1.1.1.37, MDH_METFE)
7	Ec:mdh Hi:HIN0619 Hp:- Sy:sll0891	Bsub: LDH_BACSU Mgen:MG460 Mpne:MP168 Mtub:	Mjan:MJ0490 Mthe:35960162 Aful:AF5468L Sulf: ot:MDH_HALMA	Yeast:YKL085w Celeg:1078878 Human:LDHM_HUMAN Plant:LDHA_HORVU	1LLC 9LDB 5LDH 1LDM 1LDN 1LLD	Malate dehydrogenase (EC 1.1.1.37, MDH_BACSU)
4. D-lactate dehydrogenase (EC 1.1.1.28)
8	Ec:DLD_ECOLI Hi:LDHD_HAEIN Hp: Sy:	Bsub:- Mgen:- Mpne: Mtub:	Mjan:- Mthe: Aful:2649802 Sulf:	Yeast:- Celeg: Human: Plant:		Glycolate oxidase subunit D (GLCD_ECOLI)
9	Ec:LDHD_ECOLI Hi:DDH_HAEIN Hp:HP0397 Sy:slr1556   ot:DDH_ZYMMO	Bsub:SERA_BACSU Mgen:- Mpne:- Mtub: ot:LDHD_LACPL ot:VANH_ENTFC	Mjan:MJ1018 Mthe:29468887 Aful:AF2012L Sulf:	Yeast:SERX_YEAST Celeg:1749578 Human: Plant:DHGY_CUCSA	2DLD 1PSD 2NAC 1GDH	Fold: Flavodoxin-like Glycerate dehydrogenase (EC 1.1.1.29, DHGY_HYPME) 3-phosphoglycerate dehydrogenase (EC 1.1.1.95, SERA_BACSU)
5. Malate dehydrogenase (EC 1.1.1.37)
10	Ec:YBIC_ECOLI Hi:YIAK_HAEIN Hp:- Sy:- ot:LDH_ALCEU	Bsub:YjmC Mgen:- Mpne:- Mtub:	Mjan:MDH_METJA Mthe:3460662 Aful:- Sulf: ot:MDH_METFE	Yeast:- Celeg:F13D12.1 Human: Plant:		Archaebacterial malate dehydrogenase family L-lactate dehydrogenase (EC 1.1.1.27, LDH_ALCEU)
11	Ec:mdh Hi:HIN0619 Hp:- Sy:sll0891	Bsub: LDH_BACSU Mgen:MG460 Mpne:MP168 Mtub:	Mjan:MJ0490 Mthe:35960162 Aful:AF5468L Sulf: ot:MDH_HALMA	Yeast:- Celeg:1078878 Human:LDHM_HUMAN   Plant:LDHA_HORVU	9LDB 5LDH 1LDM 1HLP	L-lactate dehydrogenase (EC 1.1.1.27, LDH_BACSU)
6. Isocitrate dehydrogenase (EC 1.1.1.42)
12	Ec:IDH_ECOLI Hi:LEU3_HAEIN Hp:HP4718R Sy:slr1289   ot:IDH1_VIBA1	Bsub: IDH_BACSU Mgen:- Mpne: Mtub: ot:IDH_THETH	Mjan:IDH_METJA Mthe:5348202 Aful:AF4246L Sulf: ot:1592302	Yeast:IDH1_YEAST Celeg:1523930 Human:IDHA_HUMAN Plant:LEU3_SOLTU	1ISO 6ICD 1GRO 1IDD 1XAC 1IDM	Isopropylmalate dehydrogenase (EC 1.1.1.85, LEU3_NEUCR)
13	Ec:- Hi:- Hp:- Sy:- ot:IDH_AZOVI	Bsub:- Mgen:- Mpne:- Mtub: ot:ICD_CORGL	Mjan:- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant:
7. Glucose 1-dehydrogenase (EC 1.1.1.47)
14	Ec:KDUD_ECOLI Hi:FABG_HAEIN Hp:HP7120L Sy:slr0886	Bsub: DHG_BACSU Mgen:- Mpne:- Mtub:Y07E_MYCTU	Mjan:- Mthe:- Aful:AF4128R Sulf:	Yeast:FOX2_YEAST   Celeg:1301670 Human:DHB4_HUMAN Plant:FABG_CUPLA	1YBV	Short-chain dehydrogenases: 3-keto-ACP reductase (EC 1.1.1.100, FABG_ECOLI); 2-deoxygluconate dehydrogenase EC 1.1.1.125 KDUD_ERWCH)   Rossman fold
15	Ec:ADH3_ECOLI Hi:ADH3_HAEIN Hp: Sy:sll0990	Bsub:YycR Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf: ot:DHG_THEAC	Yeast:ADH3_YEAST  Celeg:1263478 Human:ADHA_HUMAN  ot:ADH1_RANPE	1HDX 1HDY 1HDZ	Zn-containing dehydrogenases: alcohol dehydrogenase (EC 1.1.1.1, ADHA_UROHA)   Rossman fold (Same RMSD=3.7)
8. 3-Alpha-hydroxy-steroid dehydrogenase (EC 1.1.1.50)
16	Ec:YJGI_ECOLI Hi:FABG_HAEIN Hp:HP7120L Sy:slr2124 ot:JN0829	Bsub:DHG_BACSU Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:AF4128R Sulf:	Yeast:SP19_YEAST  Celeg:W01C9.4 Human:S66665 Plant:	1AHH 1AHI 1CYD	Rossman fold
17	Ec:YQHE_ECOLI Hi:- Hp:- Sy:slr0942	Bsub:YvgN Mgen:- Mpne:- Mtub:1694860	Mjan:- Mthe:- Aful:- Sulf:	Yeast:YHQ4_YEAST  Celeg:ZC443.1 Human:1815604 ot:DIDH_RAT	1RAL 1AFS 1DLA 1ABN 1FRB	TIM-barrel
9. 17-Beta-hydroxy-steroid dehydrogenase (EC 1.1.1.62)
18	Ec:YOHF_ECOLI Hi:FABG_HAEIN Hp:HP1464L Sy:slr0315	Bsub:YusZ Mgen:- Mpne: Mtub:Y04M_MYCTU	Mjan:- Mthe: Aful:AF4128R Sulf:	Yeast:YMR226c Celeg: Human:DHB1_HUMAN Plant:	1FDS 1BHS 1IOL	Short-chain dehydrogenases Rossmann fold
19	Ec:YAFB_ECOLI Hi: Hp:- Sy:slr0942	Bsub:YvgN Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast:GCY_YEAST Celeg:1707239 Human:DBDD_HUMAN  Plant:6DCS_SOYBN   ot:A56424	1AFS 1RAL 1DLA 1ADS 1FRB	TIM-barrel fold
10. Formate dehydrogenase (EC 1.2.1.2)
20	Ec:FDHF_ECOLI Hi:BISC_HAEIN Hp:HP5225L Sy:sll1454   ot:S18213	Bsub:YjgC Mgen:- Mpne:- Mtub:YX31_MYCTU	Mjan:MJ0005 Mthe:S63554 Aful:AF7266L Sulf: ot:FDHA_METFO	Yeast: Celeg: Human: Plant:	1AA6	Nitrate reductase (EC 1.7.99.4, NASC_BACSU), dimethyl sulfoxide reductase (DMSA_ECOLI)
21	Ec:SERA_ECOLI Hi:SERA_HAEIN Hp:HP6358L Sy:1653783   ot:FDH_PSESR	Bsub:SerA Mgen:- Mpne:- Mtub: ot:1477947	Mjan:MJ1018 Mthe:29468887 Aful:AF2012L Sulf:	Yeast:YOR388c Celeg:1749578 Human: Plant:FDH_SOLTU ot:FDH_NEUCR FDH_HANPO	2NAC 2NAD 1DLD	Glycerate dehydrogenase (EC 1.1.1.29, DHGY_HYPME), 3-phosphoglycerate dehydrogenase (EC 1.1.1.95, SERA_BACSU)   Fold: Flavodoxin-like
11. Carbon monoxide dehydrogenase (EC 1.2.99.2)
22	Ec:- Hi:- Hp:- Sy:-	Bsub:- Mgen:- Mpne: Mtub: ot: DCMA_CLOTH	Mjan:MJ0152 Mthe:9964715 Aful:AF7175R Sulf: ot:1575540	Yeast:- Celeg:- Human:- Plant:		DCMA_CLOTH is Ni-dependent; DCMB_CLOTH is similar to DCMA_METSO and other FeS center-containing proteins
23	Ec:1786478 Hi:- Hp:- Sy:- ot:C56279	Bsub:YurC Mgen:- Mpne: Mtub:	Mjan:- Mthe: Aful: Sulf:1707756	Yeast:- Celeg:1731954 Human:ADO_HUMAN Plant: ot:XDH_HUMAN	1ALO	Nicotine dehydrogenase (EC 1.5.99.4); aldehyde oxidase (EC 1.2.3.1); xanthine dehydrogenase (EC 1.1.1.204)
12. Protochlorophyllide reductase (EC 1.3.1.33)
24	Ec:- Hi:- Hp:- Sy: CHLN_SYNY3   ot:BCHN_RHOCA	Bsub:- Mgen:- Mpne: Mtub:	Mjan:- Mthe:20942825 Aful:- Sulf: ot	Yeast:- Celeg:- Human:- Plant:CHLN_PINCO ot:CHLN_CHLRE ot:CHLN_MARPO	3MIN  1MIO	Light-independent form is found in cyanobacteria and chloroplasts of all plants, except angiosperms Nitrogenase Fe-Mo fold
25	Ec:- Hi:- Hp: Sy:slr0506	Bsub:YxbG Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast:YMR226c Celeg:1703589 Human:DHCA_HUMAN   Plant: PCR_ARATH PCR_PEA	1FDS	Light-dependent form, is nuclear-encoded, found in cyanobacteria and chloroplasts of angiosperms Rossmann fold
13.Dihydrofolate reductase (EC 1.5.1.3)
26	Ec:DYRA_ECOLI Hi:DYRA_HAEIN Hp:- Sy:-	Bsub: DYR_BACSU Mgen:MG228 Mpne:MP517 Mtub:	Mjan:- Mthe:- Aful:- Sulf: ot:DYR_HALVO	Yeast:DYR_YEAST Celeg:1546725 Human:DYR_HUMAN Plant:DYR_SOYBN ot:DRTS_PLAFK	1DHJ 4DFR 5DFR 1RA9
27	Ec:DYR2_ECOLI Hi:- Hp:- Sy:- ot:DYR3_ECOLI	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:- Mthe: Aful: Sulf:	Yeast:- Celeg:- Human:- Plant:	1VIE	Plasmid-encoded methotrexate resistance gene
14. NADH dehydrogenase (EC 1.6.99.3)
28	Ec:NUOF_ECOLI Hi:- Hp:- Sy:sll1221 ot:NQO1_PARDE	Bsub:- Mgen:- Mpne:- Mtub:1781218	Mjan:- Mthe:24428454 Aful:- Sulf:	Yeast:- Celeg:908831 Human:NUBM_HUMAN Plant:S52261 ot:NUBM_NEUCR
29	Ec:TRXB_ECOLI Hi:TRXB_HAEIN Hp:HP1184R Sy:slr1849 ot:AHPF_SALTY	Bsub:DNHA_BACSU Mgen:MG102 Mpne:MP592 Mtub:TRXB_MYCTU ot:DHNA_BACSP	Mjan:MJ1536 Mthe:5111643 Aful:AF2819L Sulf:	Yeast:YDR353w Celeg:1226269 Human: Plant:	1VDC 1TDE 1TDF 1TRB
15. Diphenol (polyphenol) oxidase (EC 1.10.3.1)
30	Ec:- Hi:- Hp:- Sy:-	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast:SUN2_YEAST  Celeg:DXA2_CAEEL Human: Plant:JQ2257 ot:DXA2_DROME
31	Ec:- Hi:- Hp:- Sy:- ot:TYRO_RHIME	Bsub:- Mgen:- Mpne:- Mtub: ot:TYRO_STRAT	Mjan:- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant: PPO_SPIOL PPOA_LYCES	1LLA 1OXY 1HC1	Monophenol monooxygenase (EC 1.14.18.1, TYRO_STRAT)
16. Cytochrome c peroxidase (EC 1.11.1.5)
32	Ec:YHJA_ECOLI Hi:- Hp:HP4015R Sy:- ot:CCPR_PSESP	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant:
33	Ec:CATA_ECOLI Hi:- Hp:- Sy:sll1987   ot:CATA_RHOCA	Bsub:- Mgen:- Mpne:- Mtub:CATA_MYCTU ot:CATA_BACST	Mjan:- Mthe:- Aful:AF0388L Sulf:	Yeast:CCPR_YEAST Celeg: Human: Plant:APX1_PEA	2CYP 1CCA 1CCP 1CCB	Catalase (1.11.1.6, CATA_ARATH)   Fold: Heme-dependent peroxidases
17. Catalase (EC 1.11.1.6)
34	Ec:CATA_ECOLI Hi:- Hp:- Sy:sll1987   ot:CATA_RHOCA	Bsub: - Mgen:- Mpne:- Mtub:CATA_MYCTU ot: CATA_BACST	Mjan:- Mthe:- Aful:AF0388L Sulf:	Yeast:CCPR_YEAST Celeg: Human: Plant:APX1_PEA	2CYP 1CCA 1CCP 4CCX 1RYC	Catalase HPI,   Fold: Heme-dependent peroxidases
35	Ec:CATE_ECOLI Hi:CATA_HAEIN Hp:HP1389L ot:CATA_BORPE Sy:-	Bsub:CATV_BACSU Mgen:- Mpne:- ot:CATB_BACSU ot:CATE_MYCAV	Mjan:- Mthe:- Aful:- Sulf:	Yeast:CATA_YEAST  Celeg:S49452 Human:CATA_HUMAN Plant:CAT1_TOBAC ot:CATA_DROME	2CAH 7CAT 1RYC 1APX 1IPH	Catalase HPII
36	Ec:- Hi:- Hp:- Sy:-	Bsub:YdbD Mgen:- Mpne:- Mtub: ot: 1752756	Mjan:- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant:
18. Peroxidase (EC 1.11.1.7)
37	Ec:- Hi:- Hp:- Sy:-	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast: Celeg:1067049 Human:PERM_HUMAN Plant: ot:PERO_DROME	1MYP 1MHL
38	Ec:- Hi:- Hp:- Sy:-	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast: Celeg: Human: Plant: PERX_SOLTU PER1_HORVU	1SCH 4CCP 1BGP 2CYP 1RYC	Same fold RMSD=4.9
19. Chloroperoxidase (EC 1.11.1.10)
39	Ec:1786545 Hi:- Hp:- Sy:slr0314 ot:PRXC_PSEPY	Bsub:YisY Mgen:- Mpne:- Mtub:- ot:PRXC_STRLI BPA1_STRAU	Mjan:- Mthe:- Aful:AF5437R Sulf:	Yeast:YNR064c Celeg:K07C5.5 Human:HYES_HUMAN  Plant:1304227	1BRO	Bromoperoxidase (EC 1.11.1.-, BPA1_STRAU) Epoxide hydrolase (EC 3.3.2.3, HYES_RAT)
40	Ec:- Hi:- Hp:- Sy:-	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant: ot:PRXC_CALFU	2CPO
41	Ec:- Hi:- Hp:- Sy:-	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast: Celeg: Human: Plant: ot:PRXC_CURIN	1VNC	Vanadium chloro-peroxidase
20. Alkane 1-monooxygenase (EC 1.14.15.3)
42	Ec:- Hi:- Hp:- Sy:- ot:ALKB_PSEOL	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast:- Celeg:- Human:- Plant:
43	Ec:- Hi:- Hp:- Sy:slr0574	Bsub:YrhJ Mgen:- Mpne:- Mtub:- ot:CPXB_BACME	Mjan:- Mthe:- Aful:- Sulf:	Yeast:ERG5_YEAST Celeg:1403284 Human:CP4B_HUMAN Plant:CP78_MAIZE	2BMH 2HPD 1FAH
21. Superoxide dismutase (EC 1.15.1.1)
44	Ec:SODC_ECOLI Hi:SODC_HAEIN Hp:- Sy: ot:SODC_CAUCR	Bsub:YojM Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast:SODC_YEAST Celeg:SODC_CAEEL   Human:SODC_HUMAN Plant:SODP_SPIOL SODP_PINSY	1SRD 1COB 2SOD 3SOD	Cu/Zn SODs are found in bacteria, chloroplasts and cytoplasm of eukaryotic cell
45	Ec:SODF_ECOLI Hi:SODM_HAEIN Hp:SODF_HELPY Sy:slr1516 ot:SODF_PSEAE	Bsub:SODM_BACSU Mgen:- Mpne:- Mtub:SODF_MYCTU ot:SODM_CORDI	Mjan:- Mthe:SODF_METTH Aful:- Sulf:SODF_SULAC ot:SODM_HALHA	Yeast:SODM_YEAST Celeg:SODM_CAEEL Human:SODM_HUMAN Plant:SODF_ARATH SODP_MAIZE ot:SODF_ENTHI	1ABM 1IDS 1ISA 3SDP 3MDS	Mn/Fe SODs are found in bacteria and archaea; in eukaryotes, in mitochondria and chloroplasts only
22. Ribonucleoside triphosphate reductase (EC 1.17.4.2)
46	Ec:RIR1_ECOLI Hi:RIR1_HAEIN Hp:- ot:RIR1_SALTY Sy:1653420	Bsub:- Mgen:- Mpne:S73838 Mtub:   ot: 308869	Mjan:- Mthe:33756317 Aful:AF2435R Sulf:   ot: 1657993	Yeast:RIR1_YEAST Celeg:RIR1_CAEEL Human:RIR1_HUMAN Plant:   ot:RIR1_DROME	1RLR	Ribonucleoside-diphosphate reductase (EC 1.17.4.1, RIR1_YEAST); Viral protein VG50_BPML5;
47	Ec:NRDD_ECOLI Hi:NRDD_HAEIN Hp:- Sy:-	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:MJ0832 Mthe:26254387 Aful: Sulf:	Yeast:- Celeg: Human: Plant:		Viral protein NRDD_BPT4
23. Hydrogenase (EC 1.18.99.1)
48	Ec:NUOG_ECOLI Hi:- Hp:HP3142R ot:PHFL_DESVH Sy:sll1223	Bsub:YrhE Mgen:- Mpne:- Mtub: ot:PHF1_CLOPA	Mjan:MJ1303 Mthe:S57430 Aful:AF6863L Sulf: ot:FDHA_METFO	Yeast:YNY0_YEAST  Celeg:459011 Human:NUAM_HUMAN  Plant: ot:1171117	1FCA 1CLF
49	Ec:MBHM_ECOLI Hi:- Hp:HP0332R Sy:sll1226   ot:PHNL_DESVM	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:MJ0029 Mthe:FRHA_METTH Aful:AF3480R Sulf: ot:S49929	Yeast:- Celeg: Human: Plant:	1FRV	Coenzyme F420 hydrogenase (EC 1.12.99.1, FRHA_METVO)
24. Phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17)
50	Ec:YIGO_ECOLI Hi:Y912_HAEIN Hp:HP6458L Sy:sll1407   ot:PMTA_RHOSH	Bsub:GRC2_BACSU Mgen:- Mpne:- Mtub:	Mjan:MJ1123 Mthe: Aful:AF8050L Sulf: ot:1124958	Yeast:- Celeg: Human: Plant:	1AQI 1XVA 1AQJ	In eukaryotes, sim only to a chloroplast protein(1419090)
51	Ec:- Hi:- Hp:- Sy:-	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:- Mthe: Aful: Sulf:	Yeast:PEM1_YEAST Celeg: Human: Plant:
25. Glycerol-3-phosphate O-acyltransferase (EC 2.3.1.15)
52	Ec:PLSB_ECOLI Hi:PLSB_HAEIN Hp:- Sy:1652152	Bsub:ThdF Mgen:- Mpne:- Mtub:Y04E_MYCTU	Mjan:- Mthe: Aful: Sulf:	Yeast:- Celeg:F08F3.2 Human: Plant: ot:A41672		1-Acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51, PLSC_ECOLI)
53	Ec:- Hi:- Hp:- Sy:-	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful: Sulf:	Yeast:- Celeg: Human: Plant: PLSB_CUCMO PLSB_PEA
26. Chloramphenicol acetyltransferase (EC 2.3.1.28)
54	Ec:CAT_ECOLI Hi:CAT2_HAEIN Hp:- Sy:-	Bsub:- Mgen:- Mpne:- Mtub:- ot: CAT_STRAC CAT1_STAAU	Mjan:- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant:	1CLA 1QCA 4CLA 1CIA
55	Ec:CAT4_ECOLI Hi:- Hp:- Sy:sll1900 ot:CAT4_AGRTU	Bsub:YyaI Mgen:- Mpne: Mtub:-	Mjan:MJ1064 Mthe:33881910 Aful:- Sulf:	Yeast:YJV8_YEAST Celeg: Human: Plant:	1LXA 1THJ	Galactoside O-acetyltransferase (EC 2.3.1.18, THGA_ECOLI)
27. Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43)
56	Ec:- Hi:- Hp:- Sy:- ot:GCAT_AERHY	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant:		Phospholipase A2 HLT_VIBPA; lipase (EC 3.1.1.3, LIP1_PHOLU);
57	Ec:- Hi:- Hp:- Sy:-	Bsub:- Mgen:- Mpne: Mtub:- ot:1017754	Mjan:- Mthe:- Aful:- Sulf:	Yeast:YN84_YEAST  Celeg:1279319 Human:LCAT_HUMAN Plant: ot:LCAT_CHICK
N-terminal acetyltransferase (EC 2.3.1.88)
	-	YAD5-CLOAB	MJ0263	Yeast:NAT1_YEAST		These two enzymes differ in substrate specificity and should have been assigned different EC numbers
	-	-	-	Yeast:NAT2_YEAST
28. Protein-glutamine-gamma-glutamyl transferase (EC 2.3.2.13)
58	Ec:- Hi:- Hp:- Sy:-	Bsub:- Mgen:- Mpne: Mtub:- ot: JC2089	Mjan:- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant:		Activity of the 3-d type of gamma-glutamyltransferase (L48925) has not been shown experimentally
59	Ec:- Hi:- Hp:- Sy:-	Bsub: Mgen:- Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human:TGLK_HUMAN Plant: ot: TGLK_RABIT	1GGT 1FIE	Coagulation factor XIII (F13A_HUMAN)
29. 4-Alpha-glucanotransferase (EC 2.4.1.25)
60	Ec:MALQ_ECOLI Hi:MALQ_HAEIN Hp:- Sy:sl1676	Bsub: Mgen:- Mpne: Mtub:- ot:MALQ_STRPN	Mjan:- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant: DPEP_SOLTU
61	Ec:TREC_ECOLI Hi:GLGX_HAEIN Hp:- Sy:sll0842   ot:S60618	Bsub:TreA Mgen:- Mpne: Mtub:- ot:DEXB_STRMU	Mjan:- Mthe:- Aful:- Sulf:	Yeast:MA1S_YEAST  Celeg:527426 Human:GDE_HUMAN Plant:AMY3_WHEAT  ot:GDE_RABIT AMY3_DICTH	1PAM 1CIU 1TCM 1CGV 1CGW 1CXF 1CGT	Alpha-amylase (EC 3.2.1.1, AMY_BACSU); maltase (EC 3.2.1.20, MA6S_YEAST); cyclomaltodextrin glucano-transferase(EC 2.4.1.19, CDGT_BACST)
NAD-diphtamide ADP-ribosyltransferase (EC 2.4.2.36)
	Ec:- Hi:- Hp:- Sy:-	Bsub:- Mgen:- Mpne:- Mtub:- ot:DTX_CORBE	Mjan:- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant: ot:CHCB_BOMMO	1DDT 1DTP	Enterotoxin TOXA_PSEAE
	Ec:ELAP_ECOLI Hi:- Hp:- Sy:- ot:CHTA_VIBCH	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:-- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant:	1XTC 1LTA 1LTB	Pertussis toxin TOX1_BORPE   Same fold, RMSD=3.5
30. Glutathione S-transferase (EC 2.5.1.18)
62	Ec:GT_ECOLI Hi:GT_HAEIN Hp:- Sy:sll0067 ot:1050750	Bsub: Mgen:- Mpne:- Mtub:	Mjan:-- Mthe:- Aful:- Sulf:	Yeast:URE2_YEAST Celeg:967036 Human:GTT1_HUMAN Plant: GTH1_WHEAT ot:JC5114 GTT1_DROME	1GSE 1GUH 1AGS
63	Ec:- Hi:- Hp:- Sy:-	Bsub: Mgen:- Mpne:- Mtub:	Mjan:-- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human:GTMI_HUMAN Plant: ot:GTMI_RAT
31. Alanine-glyoxylate aminotransferase (EC 2.6.1.44)
64	Ec:- Hi:- Hp:HP0818L Sy:sll1559   ot:DHSS_ANACY	Bsub:YurG Mgen:- Mpne:- Mtub:SERC_MYCTU	Mjan:MJ0959 Mthe:F2_276 Aful:AF3320R ot:JC2256 Sulf:	Yeast:YFD0_YEAST  Celeg:T14D7.1 Human:SPYA_HUMAN Plant: ot:SPYA_RABIT	1AAW 1ASL 1ASM 1AJS	In eukaryotes, this enzyme is found in mitochondria and peroxisomes   Same fold, RMSD=4.1
65	Ec:GABT_ECOLI Hi:Y949_HAEIN Hp:HP1845L Sy:slr1022	Bsub:YhxA Mgen:- Mpne:- Mtub:1478223 ot:YKAB_BACFI  GABT_MYCLE	Mjan:MJ0721 Mthe:C2_813 Aful:AF8244L Sulf: ot:1127769	Yeast:OAT_YEAST Celeg:1707274 Human:1093492 Plant: ot:1000448	1DGD 2DKB	Dialkylglycine decarboxylase (EC 4.1.1.64, DGDA_BURCE); Gamma-aminobutyrate aminotransferase (EC 2.6.1.19, GABT_ECOLI) This enzyme was found in rat kidney mitochondria
32. Glucokinase (EC 2.7.1.2)
66	Ec:HXKG_ECOLI Hi:YAJF_HAEIN Hp:HP2377R Sy:sll0593   ot:HXKG_ZYMMO	Bsub:- Mgen:- Mpne:- Mtub:	Mjan:-- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant:		Common motif
67	Ec:YHCI_ECOLI Hi:YHCI_HAEIN Hp:- Sy:slr0329	Bsub:YqgR Mgen:- Mpne:- Mtub:- ot: GLK_STRCO	Mjan:- Mthe:- Aful:AF1312R Sulf:	Yeast:- Celeg: Human: Plant:		Fructokinase (EC 2.7.1.4, SCRK_PEDPE) This group has a common motif with the previous one
68	Ec:- Hi:- Hp:- Sy:-	Bsub:- Mgen: Mpne:- Mtub:	Mjan:- Mthe:- Aful:- Sulf:	Yeast:HXKG_YEAST Celeg:F14B4.2 Human:HXK1_HUMAN Plant:S71205 ot: 1619590 HXK_PLAFA	1HKG 2YHX	Fold: Ribonuclease H-like motif
33. Fructokinase (EC 2.7.1.4)
69	Ec:SCRK_ECOLI Hi:KDGK_HAEIN Hp:- Sy:slr1448   ot:KDGK_ECOLI	Bsub:YdjE Mgen:- Mpne:- Mtub:1666148	Mjan:MJ0406 Mthe:C2_1008 Aful:AF7085L Sulf:1706952	Yeast:RBSK_YEAST  Celeg:F07A11.5 Human:KHK_HUMAN Plant: SCRK_SOLTU
70	Ec:- Hi:- Hp:- Sy:- ot:SCRK_ZYMMO	Bsub:YdhR Mgen:- Mpne:- Mtub:1877388 ot:SCRK_STRMU	Mjan:-- Mthe:- Aful:- Sulf:	Yeast:- Celeg: Human: Plant:		Glucokinase (EC 2.7.1.2, GLK_STRCO)
34. 6-Phosphofructokinase (EC 2.7.1.11)
71	Ec:K6P1_ECOLI Hi:K