| No. |
EC no. |
Enzyme name |
Example |
PDB |
SCOP fold |
Family (Pfam) |
Ref. |
Comments |
| 1 |
1.1.1.1 |
Alcohol dehydrogenase (NAD+) |
ADH1B_HUMAN |
1HDY |
GroES-like & Rossmann-fold |
Zinc-contaning alcohol dehydrogenase |
PubMed |
Three distinct structural folds |
| 1.1.1.1 |
Alcohol dehydrogenase (NAD+) |
ADH4_YEAST |
2BI4 |
Dehydroquinate synthase-like |
Iron-contaning alcohol dehydrogenase |
PubMed |
| 1.1.1.1 |
Alcohol dehydrogenase (NAD+) |
ADH_DROME |
1MG5 |
Rossmann-fold |
Short chain dehydrogenase |
PubMed |
| 2 |
1.1.1.2 |
Alcohol dehydrogenase (NADP+) |
ADHC_MYCBO |
1YQD |
GroES-like & Rossmann-fold |
Zinc-contaning alcohol dehydrogenase |
PubMed |
Three distinct structural folds |
| 1.1.1.2 |
Alcohol dehydrogenase (NADP+) |
AK1A1_HUMAN |
2ALR |
TIM beta/alpha-barrel |
Aldo/keto reductase |
PubMed |
| 1.1.1.2 |
Alcohol dehydrogenase (NADP+) |
ADH4_SCHPO |
1O2D |
Dehydroquinate synthase-like |
Iron-contaning alcohol dehydrogenase |
PubMed |
| 3 |
1.1.1.27 |
L-lactate dehydrogenase |
LDHA_HUMAN |
1EZ4 |
Rossmann-fold & LDH C-terminal domain |
Lactate & malate dehydrogenases |
PubMed |
Two distinct structural folds |
| 1.1.1.27 |
L-lactate dehydrogenase |
LDH_RALEH |
1VBI |
L-sulfolactate dehydrogenase-like |
Malate/L-Lactate dehydrogenases |
PubMed |
| 4 |
1.1.1.28 |
D-lactate dehydrogenase |
LDHD_ECOLI |
2DLD |
Rossmann-fold & Flavodoxin-like |
Formate/glycerate dehydrogenases |
PubMed |
Two distinct structural folds |
| 1.1.1.28 |
D-lactate dehydrogenase |
DLD_ECOLI |
1F0X |
FAD-binding domain & Ferredoxin-like |
D-lactate dehydrogenase |
PubMed |
| 5 |
1.1.1.37 |
Malate dehydrogenase |
MDH_HALMA |
2J5K |
Rossmann-fold & LDH C-terminal domain |
L-lactate/malate dehydrogenases |
PubMed |
Two distinct structural folds |
| 1.1.1.37 |
Malate dehydrogenase |
MDH_METFE |
2G8Y |
L-sulfolactate dehydrogenase-like |
Malate/L-Lactate dehydrogenases |
PubMed |
| 6 |
1.1.1.42 |
Isocitrate dehydrogenase (NADP+) |
IDH_ECOLI |
1IDC |
Isocitrate/Isopropylmalate dehydrogenase-like |
Isocitrate/isopropylmalate dehydrogenase |
PubMed |
Same fold, same superfamily |
| 1.1.1.42 |
Isocitrate dehydrogenase (NADP+) |
IDH_AZOVI |
1ITW |
Isocitrate/Isopropylmalate dehydrogenase-like |
Monomeric isocitrate dehydrogenase |
PubMed |
| 7 |
1.1.1.47 |
Glucose 1-dehydrogenase |
DHG_BACSU |
1GCO |
Rossmann-fold |
Short chain dehydrogenase |
PubMed |
Two distinct structural folds |
| 1.1.1.47 |
Glucose 1-dehydrogenase |
DHG_THEAC |
1HDZ |
GroES-like |
Alcohol dehydrogenase GroES-like domain |
PubMed |
| 8 |
1.1.1.50 |
3alpha-hydroxysteroid dehydrogenase |
Q9ZFY9_COMTE |
1FJH |
Rossmann-fold |
Short chain dehydrogenase |
PubMed |
Two distinct structural folds |
| 1.1.1.50 |
3alpha-hydroxysteroid dehydrogenase |
AK1C4_HUMAN |
2FVL |
TIM beta/alpha barrel |
Aldo/keto reductase |
PubMed |
| 9 |
1.1.1.62 |
Estradiol 17ß-dehydrogenase |
DHB1_HUMAN |
1FDS |
Rossmann-fold |
Short chain dehydrogenase |
PubMed |
Two distinct structural folds |
| 1.1.1.62 |
Estradiol 17ß-dehydrogenase |
DHB5_MOUSE |
1Q5M |
TIM beta/alpha barrel |
Aldo/keto reductase |
PubMed |
| 10 |
1.2.1.2 |
Formate dehydrogenase |
FDHF_ECOLI |
1FDI |
Formate dehydrogenase/ DMSO reductase |
Molybdopterin-containing oxidoreductases |
PubMed |
Two distinct structural folds |
| 1.2.1.2 |
Formate dehydrogenase |
FDH_PSESR |
2NAC |
Rossmann-fold & Flavodoxin-like |
2-hydroxyacid dehydrogenases |
PubMed |
| 11 |
1.2.99.2 |
Carbon-monoxide dehydrogenase |
DCML_OLICO |
1N60 |
CO dehydrogenase ISP C-domain like and others |
|
PubMed |
Two distinct structural folds |
| 1.2.99.2 |
Carbon-monoxide dehydrogenase |
COOS_RHORU |
1JQK |
Prismane protein-like |
Prismane/CO dehydrogenase family |
PubMed |
| 12 |
1.3.1.33 |
Protochlorophyllide reductase |
BCHN_RHOCA |
3MIN |
Nitrogenase Fe-Mo fold |
Protochlorophyllide reductase |
PubMed |
The two forms use different electron donors |
| 1.3.1.33 |
Protochlorophyllide reductase |
PORB_ARATH |
1hdu |
Rossmann-fold |
Short chain dehydrogenase |
PubMed |
| 13 |
1.5.1.3 |
Dihydrofolate reductase |
DYR_BACSU |
1MVS |
Dihydrofolate reductase-like |
Dihydrofolate reductases |
PubMed |
Two distinct structural folds |
| 1.5.1.3 |
Dihydrofolate reductase |
FOLM_ECOLI |
3edm |
Rossmann-fold |
Short chain dehydrogenase |
PubMed |
| 14 |
1.6.99.3 |
NADH dehydrogenase |
DHNA_BACYN |
1XHC |
FAD/NAD(P)-binding domain |
NADH dehydrogenase |
PubMed |
Two distinct structural folds |
| 1.6.99.3 |
NADH dehydrogenase |
NDUS1_HUMAN |
2FUG |
Formate dehydrogenase/ DMSO reductase |
Complex I 75 kDa subunit family |
PubMed |
| 15 |
1.10.3.1 |
Catechol oxidase |
DXA2_DROME |
N/A |
Corrected to PSMD3_DROME, 26S proteasome regulatory subunit 3 |
PubMed |
Misassignment corrected |
| 1.10.3.1 |
Diphenol oxidase |
PPO_SPIOL |
1BT1 |
Di-copper centre-containing domain |
|
PubMed |
| 16 |
1.11.1.5 |
Cytochrome-c peroxidase |
CCPR_PSEAE |
1EB7 |
Cytochrome c |
Di-heme cytochrome c peroxidase |
PubMed |
Two distinct structural folds |
| 1.11.1.5 |
Cytochrome-c peroxidase |
CCPR_YEAST |
1EBE |
Heme-dependent peroxidases |
Peroxidase |
PubMed |
| 17 |
1.11.1.6 |
Catalase |
CATA_HUMAN |
1QQW |
Heme-dependent catalase |
Heme-dependent catalase |
PubMed |
Three distinct structural folds |
| 1.11.1.6 |
Catalase |
CATA_ECOLI |
2FXG |
Heme-dependent peroxidases |
Peroxidase |
PubMed |
| 1.11.1.6 |
Catalase |
MCAT_LACPL |
1JKU |
Ferritin-like |
Manganese catalase |
PubMed |
| 18 |
1.11.1.7 |
Peroxidase |
PRDX6_MOUSE |
1PRX |
Thioredoxin |
Thioredoxin |
PubMed |
Three distinct structural folds |
| 1.11.1.7 |
Peroxidase |
PERM_HUMAN |
1MYP |
Heme-dependent peroxidases |
Animal heme peroxidase |
PubMed |
| 1.11.1.7 |
Peroxidase |
YCDB_ECOLI |
2D3Q |
Ferredoxin-like |
Dyp-type peroxidase-like |
PubMed |
| 19 |
1.11.1.10 |
Chloride peroxidase |
PRXC_PSEPY |
1A88 |
Alpha/beta-hydrolases |
Haloperoxidase |
PubMed |
Three distinct structural folds |
| 1.11.1.10 |
Chloride peroxidase |
PRXC_CURIN |
1VNC |
Acid phosphatase |
Type 2 phosphatidic acid phosphatase (PAP2) |
PubMed |
| 1.11.1.10 |
Chloride peroxidase |
PRXC_CALFU |
2CPO |
EF Hand-like |
Cloroperoxidase |
PubMed |
| 20 |
1.14.15.3 |
Alkane 1-monooxygenase |
ALKB_PSEOL |
1AFR |
Ferritin-like (predicted) |
Fatty acid desaturase |
PubMed |
Two distinct structural folds |
| 1.14.15.3 |
Alkane 1-monooxygenase |
CP4AM_HUMAN |
1TQN |
Cytochrome P450 |
Cytochrome P450 |
PubMed |
| 21 |
1.15.1.1 |
Superoxide dismutase |
SODF_ECOLI |
1ISA |
Fe,Mn superoxide dismutase |
Fe,Mn superoxide dismutase |
PubMed |
Three distinct structural folds |
| 1.15.1.1 |
Superoxide dismutase |
SODC_ECOLI |
1ESO |
Immunoglobulin-like beta-sandwich |
Cu,Zn superoxide dismutase |
PubMed |
| 1.15.1.1 |
Superoxide dismutase |
SODN_STRSO |
1Q0D |
Four-helical up-and-down bundle |
Nickel-containing superoxide dismutase |
PubMed |
| 22 |
1.17.4.2 |
Ribonucleoside-triphosphate reductase |
NRDD_ECOLI |
1H7A |
PFL-like glycyl radical enzymes |
Anaerobic ribonucleotide reductase |
PubMed |
Same fold, same superfamily |
| 1.17.4.2 |
Ribonucleoside-triphosphate reductase |
RTPR_LACLE |
1L1L |
PFL-like glycyl radical enzymes |
B12-dependent (class II) ribonucleotide reductase |
PubMed |
| 23 |
1.18.99.1 |
Hydrogenase (now EC 1.12.2.1) |
PHNL_DESGI |
1FRV |
HydA/Nqo6-like & HydB/Nqo4-like |
Ni-Fe hydrogenase |
PubMed |
Two distinct structural folds |
| 1.18.99.1 |
Hydrogenase (now EC 1.12.7.2) |
PHF1_CLOPA |
1FEH |
Fe-only hydrogenase |
Iron-only hydrogenase |
PubMed |
| 24 |
2.1.1.17 |
Phosphatidylethanolamine N-methyltransferase |
PMTA_RHOSH |
3DH0 |
SAM-dependent methyltransferases |
SAM-dependent methyltransferase |
PubMed |
Two distinct structural folds |
| 2.1.1.17 |
Phosphatidylethanolamine N-methyltransferase |
PEM1_YEAST |
N/A |
Integral membrane protein |
|
PubMed |
| 25 |
2.3.1.15 |
Glycerol-3-phosphate O-acyltransferase |
PLSB_ECOLI |
N/A |
|
Acyltransferase |
PubMed |
Same catalytic domain |
| 2.3.1.15 |
Glycerol-3-phosphate O-acyltransferase |
PLSB_CUCMO |
1K30 |
Glycerol-3-phosphate 1-acyltransferase |
Glycerol-3-phosphate 1-acyltransferase |
PubMed |
| 26 |
2.3.1.28 |
Chloramphenicol O-acetyltransferase |
CAT4_AGRTU |
1XAT |
Single-stranded left-handed beta-helix |
Galactoside acetyltransferase |
PubMed |
Two distinct structural folds |
| 2.3.1.28 |
Chloramphenicol O-acetyltransferase |
CAT3_ECOLX |
3CLA |
CoA-dependent acyltransferases |
Chloramphenicol acetyltransferase |
PubMed |
| 27 |
2.3.1.43 |
Phosphatidylcholine-sterol O-acyltransferase |
LCAT_HUMAN |
1ex9 |
Alpha/beta hydrolase fold (predicted) |
|
PubMed |
Two distinct structural folds |
| 2.3.1.43 |
Phosphatidylcholine-sterol O-acyltransferase |
GCAT_AERHY |
1vig |
Eukaryotic type KH-domain (predicted) |
|
PubMed |
| 28 |
2.3.2.13 |
Protein-glutamine gamma-glutamyltransferase |
F13A_HUMAN TGAS_STRMB |
1FIE 1IU4 |
Cysteine proteinases |
Transglutaminase, microbial transglutaminase |
PubMed |
Two distinct structural folds |
| 2.3.2.13 |
Protein-glutamine gamma-glutamyltransferase |
TGL_BACSU |
1ssq |
Single-stranded left-handed beta-helix (predicted) |
|
PubMed |
| 29 |
2.4.1.25 |
4-a-glucanotransferase |
MALQ_ECOLI |
1FP8 |
TIM beta/alpha-barrel |
Glycosyl hydrolase family 77 |
PubMed |
Two distinct structural folds |
| 2.4.1.25 |
4-a-glucanotransferase |
MALQ_THELI |
1K1X |
7-stranded beta/alpha barrel |
Glycosyl hydrolase family 57 |
PubMed |
| 30 |
2.5.1.18 |
Glutathione S-transferase |
GST_ECOLI GSTK1_HUMAN |
1A0F 1R4W |
Thioredoxin & GST C-terminal domain |
Glutathione S-transferase, class beta, class kappa |
PubMed |
Three distinct structural folds |
| 2.5.1.18 |
Glutathione S-transferase |
MGST1_HUMAN |
2H8A |
MAPEG domain |
MAPEG family |
PubMed |
| 2.5.1.18 |
Glutathione S-transferase |
FOSA_SERMA |
1NPB |
Glyoxalase/Bleomycin resistance protein |
Antibiotic resistance proteins |
PubMed |
| 31 |
2.6.1.44 |
Alanine-glyoxylate aminotransferase |
SPYA_HUMAN |
1H0C |
PLP-dependent transferases |
Cystathionine synthase-like |
PubMed |
Same fold, same superfamily |
| 2.6.1.44 |
Alanine-glyoxylate aminotransferase |
AGT2_RAT |
1Z3Z |
PLP-dependent transferases |
GABA-aminotransferase |
PubMed |
| 32 |
2.7.1.2 |
Glucose kinase |
GLK_ECOLI |
1SZ2 |
Ribonuclease H-like motif |
Glucokinase |
PubMed |
Same fold, same superfamily |
| 2.7.1.2 |
Glucose kinase |
GLK_STRCO |
1WOK |
Ribonuclease H-like motif |
ROK family |
PubMed |
| 2.7.1.2 |
Glucose kinase |
HXK1_HUMAN |
1DGK |
Ribonuclease H-like motif |
Hexokinase |
PubMed |
| 33 |
2.7.1.4 |
Fructokinase |
SCRK_ECOLX |
1TZ6 |
Ribokinase-like |
PfkB family carbohydrate kinase |
PubMed |
Two distinct structural folds |
| 2.7.1.4 |
Fructokinase |
SCRK_STRMU |
1XC3 |
Ribonuclease H-like motif |
Actin-like ATPase domain |
PubMed |
| 34 |
2.7.1.11 |
6-Phosphofructokinase |
K6PF1_ECOLI |
1PFK |
Phosphofructokinase |
Phosphofructokinase |
PubMed |
Two distinct structural folds |
| 2.7.1.11 |
6-Phosphofructokinase |
K6PF2_ECOLI |
3CQD |
Ribokinase-like |
PfkB family carbohydrate kinase |
PubMed |
| 35 |
2.7.1.12 |
Gluconokinase |
GNTK_ECOLI |
1KNQ |
P-loop NTPases |
Gluconate kinase |
PubMed |
Two distinct structural folds |
| 2.7.1.12 |
Gluconokinase |
GNTK_BACSU |
2ITM |
Ribonuclease H-like motif |
Glycerol kinase |
PubMed |
| 36 |
2.7.1.107 |
Diacylglycerol kinase |
KDGL_ECOLI |
N/A |
Integral membrane protein |
Prokaryotic diacylglycerol kinase |
PubMed |
Two distinct structural folds |
| 2.7.1.107 |
Diacylglycerol kinase |
DGKG_HUMAN |
2qv7 |
NAD kinase (predicted) |
Diacylglycerol kinase catalytic domain |
PubMed |
| 37 |
2.7.4.3 |
Adenylate kinase |
KAD_ECOLI |
1AKE |
P-loop NTPases |
Adenylate kinase |
PubMed |
Same structural family |
| 2.7.4.3 |
Adenylate kinase |
KADA_METVO |
1NKS |
P-loop NTPases |
Archaeal adenylate kinase |
PubMed |
| 38 |
2.7.7.2 |
FAD synthetase |
FAD1_YEAST |
3G5A |
Adenine nucleotide alpha hydrolase (predicted) |
PAPS reductase |
PubMed |
Same fold, different superfamilies, discussed in Huerta et al. |
| 2.7.7.2 |
FAD synthetase |
RIBF_CORAM |
1S4M |
Adenine nucleotide alpha hydrolase |
FAD synthetase |
PubMed |
| 39 |
2.7.7.4 |
Sulfate adenylyltransferase |
CYSN_ECOLI CYSD_ECOLI |
1ZUN |
P-loop NTPases and Adenine nucleotide alpha hydrolase |
|
PubMed |
CysD and MET3 belong to the same superfamily |
| 2.7.7.4 |
Sulfate adenylyltransferase |
MET3_YEAST |
1JEE |
Adenine nucleotide alpha hydrolase |
ATP-sulfurylase |
PubMed |
| 40 |
2.7.7.9 |
UTP-glucose-1-phosphate uridylyltransferase |
GALU_ECOLI |
2E3D |
Nucleotide-diphospho-sugar transferases |
Nucleotidyl transferase |
PubMed |
Two distinct structural folds |
| 2.7.7.9 |
UTP-glucose-1-phosphate uridylyltransferase |
UGPA_HUMAN |
2icy |
Single-stranded left-handed beta-helix |
UTP-glucose-1-phosphate uridylyltransferase |
PubMed |
| 41 |
2.7.7.12 |
Galactose-1-phosphate uridylyltransferase |
GAL7_ECOLI |
1GUP |
HIT-like |
Galactose-1-phosphate uridylyltransferase 1 |
PubMed |
Same fold, same superfamily |
| 2.7.7.12 |
Galactose-1-phosphate uridylyltransferase |
GALT_LACHE |
1gup |
HIT-like (predicted) |
Galactose-1-phosphate uridylyltransferase 2 |
PubMed |
| 42 |
2.7.7.19 |
Polynucleotide adenylyltransferase |
PCNB_ECOLI |
1MIY |
Nucleotidyltransferase & Poly A polymerase C-terminal region-like |
Poly A polymerase C-terminal region-like |
PubMed |
Same fold, same superfamily (catalytic domain) |
| 2.7.7.19 |
Polynucleotide adenylyltransferase |
PAP_HUMAN |
1Q78 |
Nucleotidyltransferase & PAP/OAS1 substrate-binding domain & Ferredoxin-like |
Poly(A) polymerase, PAP, middle domain& |
PubMed |
| 43 |
2.7.7.25 |
tRNA adenylyltransferase |
CCA_ECOLI |
1VFG |
Nucleotidyltransferase & Poly A polymerase C-terminal region-like |
Bacterial CCA-adding enzyme type 1 |
PubMed |
Same fold, same superfamily (catalytic domain) |
| 2.7.7.25 |
tRNA adenylyltransferase |
CCA_SULSH |
1UET |
Nucleotidyltransferase & PAP/OAS1 substrate-binding domain & Ferredoxin-like |
Archaeal tRNA CCA-adding enzyme substrate-binding domain |
PubMed |
| 44 |
2.7.8.8 |
CDP-diacylglycerol--serine O-phosphatidyltransferase |
PSS_ECOLI |
1BYR |
Phospholipase D/nuclease |
Phospholipase D Active site motif |
PubMed |
Two distinct structural folds |
| 2.7.8.8 |
CDP-diacylglycerol--serine O-phosphatidyltransferase |
PSS_YEAST |
N/A |
Integral membrane protein |
CDP-alcohol phosphatidyltransferase |
PubMed |
| 45 |
3.1.2.15 |
Ubiquitin thiolesterase |
UBP5_HUMAN |
2G43 |
Cysteine proteinases |
Ubiquitin carboxyl-terminal hydrolase |
PubMed |
Different activities: cleave polyubiquitin chains linked, respectively, to Lys-48 and Lys-63 |
| 3.1.2.15 |
Ubiquitin thiolesterase |
STALP_HUMAN |
2ZNR |
Cytidine deaminase-like (predicted) |
JAB1/MPN/Mov34 metalloenzyme |
PubMed |
| 46 |
3.1.3.48 |
Protein-tyrosine-phosphatase |
PTPA_STRCO |
1D1P |
Phosphotyrosine protein phosphatases I-like |
Low-molecular-weight phosphotyrosine protein phosphatases |
PubMed |
Five distinct structural folds |
| 3.1.3.48 |
Protein-tyrosine-phosphatase |
PTPRD_HUMAN |
1LAR |
Phosphotyrosine protein phosphatases II |
Higher-molecular-weight phosphotyrosine protein phosphatases |
PubMed |
| 3.1.3.48 |
Protein-tyrosine-phosphatase |
MPIP3_HUMAN |
1QB0 |
Rhodanese/Cell cycle control phosphatase |
Cell cycle control phosphatase |
PubMed |
| 3.1.3.48 |
Protein-tyrosine-phosphatase |
YWQE_BACSU |
2ANU |
7-stranded beta/alpha barrel |
PHP domain |
PubMed |
| 3.1.3.48 |
Protein-tyrosine-phosphatase |
EYA3_MOUSE |
1JUD |
HAD-like |
HAD-like hydrolase |
PubMed |
| 47 |
3.2.1.1 |
Alpha-amylase |
AMY1_ECOLI |
1EA9 |
TIM beta/alpha-barrel & Glycosyl hydrolase |
Alpha-amylase |
PubMed |
Two distinct structural folds |
| 3.2.1.1 |
Alpha-amylase |
AMYA_PYRFU |
1K1X |
7-stranded beta/alpha barrel |
Glycosyl hydrolase family 57 |
PubMed |
| 48 |
3.2.1.4 |
Cellulase |
GUNA_PSEFL |
1UT9 |
Alpha/alpha toroid |
Glycosyl hydrolase family 9 (cellulase E) |
PubMed |
At least four distinct structural folds |
| 3.2.1.4 |
Cellulase |
GUNA_CLOCE |
1EDG |
TIM beta/alpha-barrel |
Beta-glycanases |
PubMed |
| 3.2.1.4 |
Cellulase |
GUN1_STRHA |
2BOD |
7-stranded beta/alpha barrel |
Glycosyl hydrolase family 6 |
PubMed |
| 3.2.1.4 |
Cellulase |
GUNM_CLOTM |
2FVG |
Phosphorylase/hydrolase |
Cellulase M |
GenBank |
| 3.2.1.4 |
Cellulase |
GUN_ASPAC |
1KS4 |
Concanavalin A-like lectins/glucanases |
Glycosyl hydrolase family 11 (cellulase G) |
PubMed |
| 3.2.1.4 |
Cellulase |
GUNE_RUMFL |
1L0H |
Acyl carrier protein-like (predicted) |
|
PubMed |
| 3.2.1.4 |
Cellulase |
GUNA_PAELA |
2EQD |
TIM beta/alpha-barrel (predicted) |
|
PubMed |
| 49 |
3.2.1.8 |
Endo-1,4-ß-xylanase |
XYNA_BUTFI |
1XAS |
TIM beta/alpha-barrel |
beta-glycanases |
PubMed |
Two distinct structural folds |
| 3.2.1.8 |
Endo-1,4-ß-xylanase |
XYNA2_CLOSR |
1QH6 |
Concanavalin A-like lectins/ glucanases |
Glycosyl hydrolase family 11 (cellulase G) |
PubMed |
| 50 |
3.2.1.11 |
Dextranase |
DEXT_STRDO |
N/A |
|
|
PubMed |
Two distinct structural folds |
| 3.2.1.11 |
Dextranase |
DEXT_PENMI |
1OGM |
Single-stranded right-handed beta-helix |
Glycosyl hydrolase family 28
| PubMed |
| 51 |
3.2.1.14 |
Chitinase |
CHIA_SERMA |
1RD6 |
TIM beta/alpha barrel |
Type II chitinase |
PubMed |
Two distinct structural folds |
| 3.2.1.14 |
Chitinase |
CHI1_ORYSA |
2BAA |
Lysozyme-like |
Family 19 glycosidase |
PubMed |
| 52 |
3.2.1.17 |
Lysozyme |
LYS_CLOAB |
1JFX |
TIM beta/alpha barrel |
1,4-beta-N-acetylmuraminidase |
PubMed |
Two distinct structural folds |
| 3.2.1.17 |
Lysozyme |
LYS_BPP1 |
1XJT |
Lysozyme-like |
Phage lysozyme |
PubMed |
| 3.2.1.17 |
Lysozyme |
ACMA_LACLM |
2ZYC |
Lysozyme-like |
Glycosyl hydrolase family 73 |
PubMed |
| 3.2.1.17 |
Lysozyme |
LYB_BACSU |
N/A |
N/A |
|
PubMed |
| 53 |
3.2.1.20 |
Alpha-glucosidase |
MALT_CANAL |
1JI1 |
TIM beta/alpha barrel & Glycosyl-hydrolase domain |
Glycosyl hydrolase family 13 |
PubMed |
Two distinct structural folds |
| 3.2.1.20 |
Alpha-glucosidase |
AGLA_THEMA |
1OBB |
Rossmann-fold & LDH C-terminal domain |
Glycosyl hydrolase family 4 |
PubMed |
| 54 |
3.2.1.21 |
Beta-glucosidase |
BGLA_THEMA |
1OIF |
TIM beta/alpha barrel |
Glycosyl hydrolase family 1 |
PubMed |
Two distinct structural folds |
| 3.2.1.21 |
Beta-glucosidase |
BGLS_BUTFI |
1OBB |
Rossmann-fold & LDH C-terminal domain |
Glycosyl hydrolase family 3 |
PubMed |
| 55 |
3.2.1.22 |
Alpha-galactosidase |
AGAL_STRMU |
1ZY9 |
TIM beta/alpha barrel |
Glycosyl hydrolase family 36 |
PubMed |
Two distinct structural folds |
| 3.2.1.22 |
Alpha-galactosidase |
AGAL_ECOLI |
1OBB |
Rossmann-fold & LDH C-terminal_domain |
Glycosyl hydrolase family 4 |
PubMed |
| 56 |
3.2.1.23 |
Beta-galactosidase |
BGAL_ECOLI |
1BGL |
TIM beta/alpha-barrel |
Glycosyl hydrolase family 2 |
PubMed |
Same fold, same superfamily |
| 3.2.1.23 |
Beta-galactosidase |
BGAL_SULAC |
|
TIM beta/alpha-barrel |
Glycosyl hydrolase family 1 |
PubMed |
| 57 |
3.2.1.28 |
Alpha,alpha-trehalase |
TREA_ECOLI |
2JG0 |
Alpha/alpha toroid |
Glycosyl hydrolase family 37 |
PubMed |
Same fold, same superfamily |
| 3.2.1.28 |
Alpha,alpha-trehalase |
TREA_EMENI |
1H54 |
Alpha/alpha_toroid (predicted) |
Glycosyl hydrolase family 65 |
PubMed |
| 58 |
3.2.1.35 |
Hyaluronidase |
HYAL2_HUMAN |
1FCU |
TIM beta/alpha barrel |
Glycosyl hydrolase family 56 |
PubMed |
Two distinct structural folds |
| 3.2.1.35 |
Hyaluronidase |
HYLP2_BPH45 |
2PK1 |
Triple-stranded beta-helix |
Hyaluronidase_1 |
PubMed |
| 3.2.1.35 |
Hyaluronidase |
HEMO_PIG |
1HXN |
4-bladed beta-propeller |
Hemopexin domain |
PubMed |
Most likely a mistake |
| 59 |
3.2.1.37 |
Xylan 1,4-ß-xylosidase |
XYNB_BACPU |
1YIF |
5-bladed beta-propeller |
Glycosyl hydrolase family 43 |
PubMed |
Three distinct structural folds |
| 3.2.1.37 |
Xylan 1,4-ß-xylosidase |
XYNB_THESA |
1PX8 |
TIM beta/alpha barrel |
Glycosyl hydrolase family 39 |
PubMed |
| 3.2.1.37 |
Xylan 1,4-ß-xylosidase |
XYLA1_BACST |
N/A |
N/A |
Glycosyl hydrolase family 52 |
PubMed |
| 60 |
3.2.1.39 |
Glucan endo-1,3-ß-D-glucosidase |
E13A_ARATH |
2CYG |
TIM beta/alpha barrel |
Glycosyl hydrolase family 17 |
PubMed |
Three distinct structural folds |
| 3.2.1.39 |
Glucan endo-1,3-ß-D-glucosidase |
E13B_BACCI |
1UPS |
Concanavalin A-like lectins/ glucanases |
Glycosyl hydrolase family 16 |
PubMed |
| 3.2.1.39 |
Glucan endo-1,3-ß-D-glucosidase |
E13B_CELCE |
N/A |
N/A |
Glycosyl hydrolase family 64 |
PubMed |
| 61 |
3.2.1.55 |
Alpha-N-arabinofuranosidase |
ABFA_STRLI |
2C7F |
TIM beta/alpha barrel |
Glycosyl hydrolase family 51 |
PubMed |
Three distinct structural folds |
| 3.2.1.55 |
Alpha-N-arabinofuranosidase |
XYLB_BUTFI |
1YRZ |
Concanavalin A-like lectins/glucanases & 5-bladed beta-propeller |
Glycosyl hydrolase family 43 |
PubMed |
| 3.2.1.55 |
Alpha-N-arabinofuranosidase |
XYNC_PSEFL |
N/A |
5-bladed beta-propeller (predicted) |
Glycosyl hydrolase family 62 |
PubMed |
| 62 |
3.2.1.58 |
Glucan 1,3-ß-glucosidase |
EXG_CANAL |
2PB1 |
TIM beta/alpha barrel |
Glycosyl hydrolase family 5 (cellulase A) |
PubMed |
Two distinct structural folds |
| 3.2.1.58 |
Glucan 1,3-ß-glucosidase |
EXG1_COCCA |
3EQO |
Single-stranded right-handed beta-helix |
Glycosyl hydrolase family 55 |
PubMed |
| 63 |
3.2.1.73 |
Licheninase |
GUB_NICPL |
2CYG |
TIM beta/alpha barrel |
Glycosyl hydrolase family 17 |
PubMed |
Three distinct structural folds |
| 3.2.1.73 |
Licheninase |
GUB_BACSU |
1GBG |
Concanavalin A-like lectins/glucanases |
Glycosyl hydrolase family 16 |
PubMed |
| 3.2.1.73 |
Licheninase |
GUB_BACCI |
1V5C |
Alpha/alpha toroid |
Glycosyl hydrolase family 8 (cellulase D) |
PubMed |
| 64 |
3.2.1.78 |
Mannan endo-1,4-ß-mannosidase |
MANA_PSEFL |
1GW1 |
TIM beta/alpha barrel |
Glycosyl hydrolase family 26 |
PubMed |
Same fold, same superfamily |
| 3.2.1.78 |
Mannan endo-1,4-ß-mannosidase |
MANB_CALSA |
1BQC |
TIM beta/alpha barrel |
Glycosyl hydrolase family 5 |
PubMed |
| 65 |
3.2.1.81 |
ß-agarase |
AGAR_STRCO |
1QOX |
TIM beta/alpha barrel |
Glycosyl hydrolase family 1 |
PubMed |
Predicted two distinct structural folds |
| 3.2.1.81 |
ß-agarase |
AGAA_VIBS7 |
N/A |
N/A |
Glycosyl hydrolase family 50 |
PubMed |
| 3.2.1.81 |
ß-agarase |
AGAR_ALTAT |
N/A |
N/A |
Glycosyl hydrolase family 86 |
PubMed |
| 66 |
3.2.1.86 |
6-phospho-ß-glucosidase |
BGLB_ECOLI |
1QOX |
TIM beta/alpha barrel |
Glycosyl hydrolase family 1 |
PubMed |
Two distinct structural folds |
| 3.2.1.86 |
6-phospho-ß-glucosidase |
CHBF_ECOLI |
1S6Y |
Rossmann-fold & LDH C-terminal domain |
Glycosyl hydrolase family 4 |
PubMed |
| 67 |
3.2.2.21 |
DNA-3-methyladenine glycosylase |
3MG2_ECOLI |
1MPG |
DNA-glycosylase & TBP-like |
|
PubMed |
Two distinct structural folds |
| 3.2.2.21 |
DNA-3-methyladenine glycosylase |
3MG_HUMAN |
1F4R |
FMT C-terminal domain-like |
|
PubMed |
| 68 |
3.5.1.1 |
Asparaginase |
ASPG1_YEAST |
1HFW |
Glutaminase/Asparaginase |
Glutaminase/Asparaginase |
PubMed |
At least two distinct structural folds |
| 3.5.1.1 |
Asparaginase |
ASPG_HUMAN |
1APY |
Ntn_hydrolase-like |
(Glycosyl)asparaginase |
PubMed |
| 3.5.1.1 |
Asparaginase |
Q9RFN5_RHIET |
N/A |
N/A |
L-asparaginase II |
PubMed |
| 69 |
3.5.1.4 |
Amidase |
AMID_PSECL |
1OCK |
Amidase signature |
Amidase |
PubMed |
Two distinct structural folds |
| 3.5.1.4 |
Amidase |
AMIE_PSEAE |
2UXY |
Carbon-nitrogen hydrolase |
Carbon-nitrogen hydrolase |
PubMed |
| 70 |
3.5.1.11 |
Penicillin acylase |
PAC_ECOLX |
1PNL |
Ntn hydrolase-like |
Penicillin amidase |
PubMed |
Same fold, same supefamily |
| 3.5.1.11 |
Penicillin acylase |
PAC_BACSH |
2PVA |
Ntn hydrolase-like |
Linear amide C-N hydrolases |
PubMed |
| 71 |
3.5.1.28 |
N-acetylmuramoyl-L-alanine amidase |
AMPD_ECOLI |
1J3G |
N-acetylmuramoyl-L-alanine amidase-like |
N-acetylmuramoyl-L-alanine amidase-like |
PubMed |
Two distinct structural folds |
| 3.5.1.28 |
N-acetylmuramoyl-L-alanine amidase |
AMIB_ECOLI |
1JWQ |
Phosphorylase/hydrolase-like |
Zn-dependent exopeptidases |
PubMed |
| 72 |
3.5.2.6 |
ß-Lactamase |
AMPC_ECOLI |
2BLS |
Beta-lactamase/ transpeptidase-like |
Beta-lactamase |
PubMed |
Two distinct structural folds |
| 3.5.2.6 |
ß-Lactamase |
BLAB_BACCE |
1BC2 |
Metallo-hydrolase/ oxidoreductase |
Zn metallo-beta-lactamase |
PubMed |
| 73 |
3.6.1.1 |
Inorganic diphosphatase |
IPYR_ARATH |
1TWL |
OB-fold |
Pyrophosphatase |
PubMed |
Four distinct structural folds |
| 3.6.1.1 |
Inorganic diphosphatase |
AVP1_ARATH |
N/A |
Integral membrane protein |
Inorganic H+ pyrophosphatase |
PubMed |
| 3.6.1.1 |
Inorganic diphosphatase |
PPAC_BACSU |
1WPM |
DHH phosphoesterases |
DHH hydrolase |
PubMed |
| 3.6.1.1 |
Inorganic diphosphatase |
PPAX_BACSU |
2HDO |
HAD-like |
HAD-like hydrolase |
PubMed |
| 74 |
3.6.1.5 |
Apyrase |
APY_AEDAE |
1HP1 |
5-nucleotidase & Metallo-dependent phosphatases |
5'-nucleotidase |
PubMed |
Three distinct structural folds |
| 3.6.1.5 |
Apyrase |
ENTP3_HUMAN |
1T6C |
Ribonuclease H-like |
Actin-like ATPase domain |
PubMed |
| 3.6.1.5 |
Apyrase |
APY_CIMLE |
2H2N |
5-bladed beta-propeller |
Apyrase |
PubMed |
| 75 |
3.6.1.11 |
Exopolyphosphatase |
PPX_ECOLI |
1U6Z |
HD-domain/PDEase-like & Ribonuclease H-like |
Ppx associated domain |
PubMed |
Two distinct structural folds |
| 3.6.1.11 |
Exopolyphosphatase |
PPX1_YEAST |
1K20 |
DHH phosphoesterases |
Mn-dependent inorganic pyrophosphatase |
PubMed |
| 76 |
3.6.1.17 |
Bis(5'-nucleosyl) -tetraphosphatase (asymmetrical) |
APH1_SCHPO |
1FHI |
HIT-like |
HIT family |
PubMed |
Three distinct structural folds |
| 3.6.1.17 |
Bis(5'-nucleosyl) -tetraphosphatase (asymmetrical) |
AP4A_HUMAN |
1XSA |
Nudix |
MutT-like |
PubMed |
| 3.6.1.17 |
Bis(5'-nucleosyl) -tetraphosphatase (asymmetrical) |
PRPE_BACSU |
1G5B |
Metallo-dependent phosphatases |
Protein serine/threonine phosphatase |
PubMed |
| 77 |
3.8.1.2 |
2-Haloalkanoate dehalogenase |
HAD1_PSEUC |
1QQ5 |
HAD-like |
HAD-like hydrolase |
PubMed |
Different stereospecificity |
| 3.8.1.9 |
2-Haloalkanoate dehalogenase |
HADD_PSEPU |
3BJX |
N/A |
Haloacid dehalogenase DehI |
PubMed |
| 78 |
3.8.1.3 |
Haloacetate dehalogenase |
DEH1_MORSB |
1G5F |
Alpha/beta-hydrolases |
Alpha/beta hydrolase_1 |
PubMed |
Two distinct structural folds |
| 3.8.1.3 |
Haloacetate dehalogenase |
DEH2_MORSB |
1JUD |
HAD-like |
HAD-like hydrolase |
PubMed |
| 79 |
4.1.1.17 |
Ornithine decarboxylase |
DCOS_ECOLI |
1ORD |
PLP-dependent transferase |
Orn/Lys/Arg decarboxylase, class I |
PubMed |
Two distinct structural folds |
| 4.1.1.17 |
Ornithine decarboxylase |
DCOR_HUMAN |
1D7K |
TIM beta/alpha barrel |
Orn/Lys/Arg decarboxylase class II |
PubMed |
| 80 |
4.1.1.19 |
Arginine decarboxylase |
ADIA_ECOLI |
2VYC |
PLP-dependent transferase |
Orn/Lys/Arg decarboxylase, class I |
8383109, 19298070 |
Three distinct structural folds |
| 4.1.1.19 |
Arginine decarboxylase |
SPEA_ECOLI |
1TWI |
TIM beta/alpha barrel |
Orn/Lys/Arg decarboxylase class II |
PubMed |
| 4.1.1.19 |
Arginine decarboxylase |
PDAD_METJA |
1N2M |
Pyruvoyl-dependent histidine and arginine decarboxylases |
Pyruvoyl-dependent ArgDC |
PubMed |
| 81 |
4.1.1.22 |
Histidine decarboxylase |
DCHS_ENTAE |
1JS3 |
PLP-dependent transferase |
Pyridoxal-dependent decarboxylase |
PubMed |
Two distinct structural folds |
| 4.1.1.22 |
Histidine decarboxylase |
DCHS_LACS3 |
1HQ6 |
Pyruvoyl-dependent histidine and arginine decarboxylases |
Histidine decarboxylase |
PubMed |
| 82 |
4.1.1.50 |
S-adenosylmethionine decarboxylase |
SPED_ECOLI |
1TLU |
S-adenosylmethionine decarboxylase |
SAM decarboxylase |
PubMed |
Same fold, same superfamily |
| 4.1.1.50 |
S-adenosylmethionine decarboxylase |
DCAM_HUMAN |
1MSV |
S-adenosylmethionine decarboxylase |
SAM decarboxylase |
PubMed |
| 83 |
4.1.2.13 |
Fructose 1,6-bisphosphate aldolase |
ALF_ECOLI |
1DOS |
TIM beta/alpha barrel |
Fructose-bisphosphate aldolase class II |
PubMed |
Same fold, same superfamily |
| 4.1.2.13 |
Fructose 1,6-bisphosphate aldolase |
ALDOA_HUMAN |
1ALD |
TIM beta/alpha barrel |
Fructose-bisphosphate aldolase class I |
PubMed |
| 84 |
4.1.2.15 |
Phospho-2-keto-3-deoxyheptonate aldolase |
AROG_ECOLI |
1GG1 |
TIM beta/alpha barrel |
DAHP synthetase I |
PubMed |
Same fold, same superfamily |
| 4.1.2.15 |
Phospho-2-keto-3-deoxyheptonate aldolase |
AROF_STRCO |
2B7O |
TIM beta/alpha barrel |
Class-II DAHP synthetase |
PubMed |
| 85 |
4.1.2.40 |
Tagatose 1,6-bisphosphate aldolase |
KBAY_ECOLI |
1GVF |
TIM beta/alpha barrel |
Fructose-bisphosphate aldolase class II |
PubMed |
Same fold, same superfamily |
| 4.1.2.40 |
Tagatose 1,6-bisphosphate aldolase |
LACD_LACLA |
1TO3 |
TIM beta/alpha barrel |
DeoC/LacD family aldolase |
PubMed |
| 86 |
4.2.1.1 |
Carbonate dehydratase |
CYNT_ECOLI |
1EKJ |
Resolvase-like |
beta-carbonic anhydrase |
PubMed |
Three distinct structural folds |
| 4.2.1.1 |
Carbonate dehydratase |
CAH1_HUMAN |
2FOY |
Carbonic anhydrase |
|
PubMed |
| 4.2.1.1 |
Carbonate dehydratase |
CAH_METTE |
1QQ0 |
Single-stranded left-handed beta-helix |
gamma-carbonic anhydrase-like |
PubMed |
| 87 |
4.2.1.2 |
Fumarate hydratase |
FUMA_ECOLI |
2ISB |
The swivelling beta/beta/alpha domain |
Class I fumarase family |
PubMed |
Two distinct structural folds |
| 4.2.1.2 |
Fumarate hydratase |
FUMC_ECOLI |
1FUO |
L-aspartase-like |
L-aspartase/fumarase |
PubMed |
| 88 |
4.2.1.10 |
3-dehydroquinate dehydratase |
AROQ_ACTPL |
1UQR |
Flavodoxin-like |
Type II 3-dehydroquinate dehydratase |
PubMed |
Two distinct structural folds |
| 4.2.1.10 |
3-dehydroquinate dehydratase |
AROD_ECOLI |
1QFE |
TIM beta/alpha barrel |
Class I aldolase |
PubMed |
89 |
4.2.1.13 |
L-serine ammonia-lyase (now EC 4.3.1.17) |
SDHL_ECOLI |
2IQQ |
FwdE/GAPDH domain |
FeS-dependent L-serine dehydratase |
PubMed |
Two distinct structural folds |
4.2.1.13 |
L-serine ammonia-lyase (now EC 4.3.1.17) |
SDHL_HUMAN |
1PWH |
Tryptophan synthase beta subunit-like PLP-dependent enzymes |
DeoC/LacD family aldolase |
PubMed |
| 90 |
4.2.1.51 |
Prephenate dehydratase |
PHEA_ECOLI |
2QMW |
Periplasmic binding protein-like II |
Prephenate dehydratase |
PubMed |
Same fold, same superfamily |
| 4.2.1.51 |
Prephenate dehydratase |
PHEC_PSEAE |
1XT8 |
Periplasmic binding protein-like II |
Bacterial extracellular solute-binding proteins |
PubMed |
| 91 |
4.2.2.2 |
Pectate lyase |
PEL3_ERWCA |
1PLU |
Single-stranded right-handed beta-helix |
Pectate lyase C |
PubMed |
Two distinct structural folds, different families |
| 4.2.2.2 |
Pectate lyase |
PELP_PECCC |
2V8K |
Alpha/alpha toroid |
Periplasmic pectate lyase |
PubMed |
| 4.2.2.2 |
Pectate lyase |
PELL_ERWCH |
1RU4 |
Single-stranded right-handed beta-helix |
Polysaccharide lyase family 9 |
PubMed |
| 4.2.2.2 |
Pectate lyase |
Q47471_ERWCA |
3B4N |
Single-stranded right-handed beta-helix |
Pectate lyase (transeliminase) |
PubMed |
| 92 |
4.2.2.3 |
Poly(ß-D-mannuronate) lyase |
ALGL_PSEFL |
1QAZ |
Alpha/alpha toroid |
Chondroitin AC/alginate lyase |
PubMed |
Three distinct structural folds |
| 4.2.2.3 |
Poly(ß-D-mannuronate) lyase |
ALYA_KLEPN |
1VAV |
Concanavalin A-like lectins/glucanases |
Concanavalin A-like lectins/glucanases |
PubMed |
| 4.2.2.3 |
Poly(ß-D-mannuronate) lyase |
ALYP_PSESO |
1OFM |
Single-stranded right-handed beta-helix |
|
PubMed |
| 93 |
4.2.99.18 |
DNA-(apurinic or apyrimidinic site) lyase |
END3_ECOLI |
2ABK |
DNA-glycosylase |
Endonuclease III |
PubMed |
Four distinct structural folds |
| 4.2.99.18 |
DNA-(apurinic or apyrimidinic site) lyase |
APEX1_HUMAN |
1E9N |
DNase I-like |
DNase I-like |
PubMed |
| 4.2.99.18 |
DNA-(apurinic or apyrimidinic site) lyase |
APN1_YEAST |
1QTW |
TIM beta/alpha barrel |
Endonuclease IV |
PubMed |
| 4.2.99.18 |
DNA-(apurinic or apyrimidinic site) lyase |
FPG_ECOLI |
1K82 |
MutM-like DNA repair proteins |
MutM-like DNA repair proteins |
PubMed |
| 94 |
4.6.1.1 |
Adenylate cyclase |
CYAA_ECOLI |
N/A |
N/A |
Adenylate_cyclase class I |
PubMed |
Four distinct structural folds |
| 4.6.1.1 |
Adenylate cyclase |
CYAA_BORPE |
1PKO |
Immunoglobulin-like beta-sandwich |
Anthrax toxin LF (class II AC) |
PubMed |
| 4.6.1.1 |
Adenylate cyclase |
CYA1_HUMAN |
1CS4 |
Ferredoxin-like |
Adenylate/guanylate cyclase (class III AC) |
PubMed |
| 4.6.1.1 |
Adenylate cyclase |
O69199_AERHY |
2FJT |
CYTH-like phosphatases |
CYTH domain (class IV AC) |
PubMed |
| 95 |
5.2.1.8 |
Peptidylprolyl isomerase |
PPIA_ECOLI |
1CLH |
Cyclophilin-like |
Cyclophilin |
PubMed |
Two distinct structural folds |
| 5.2.1.8 |
Peptidylprolyl isomerase |
FKBA_ECOLI |
1Q6H |
FKBP-like |
FKBP-type PPIase |
PubMed |
| 96 |
5.3.1.8 |
Mannose-6-phosphate isomerase |
MANA_STRMU |
1QWR |
Double-stranded beta-helix |
RmlC-like cupins |
PubMed |
Three distinct structural folds |
| 5.3.1.8 |
Mannose-6-phosphate isomerase |
MANA_RHIME |
2GZ6 |
Six-hairpin glycosidases |
GlcNAc 2-epimerase |
PubMed |
| 5.3.1.8 |
Mannose-6-phosphate isomerase |
PGMI_SULAC |
1TZB |
SIS domain |
SIS_domain |
PubMed |
| 97 |
5.4.2.1 |
Phosphoglycerate mutase |
GPMA_ECOLI |
1E59 |
Phosphoglycerate mutase |
Phosphoglycerate mutase |
PubMed |
Two distinct structural folds |
| 5.4.2.1 |
Phosphoglycerate mutase |
GPMI_PSESM |
1EJJ |
Alkaline phosphatase-like |
2,3-BPG-independent phosphoglycerate mutase |
PubMed |
| 98 |
5.4.2.8 |
Phosphomannomutase |
RFBK_SALTY |
1K2Y |
Phosphoglucomutase |
Phosphoglucomutase |
PubMed |
Two distinct structural folds |
| 5.4.2.8 |
Phosphomannomutase |
PMM1_HUMAN |
2FUC |
HAD-like |
Eukaryotic phosphomannomutase |
PubMed |
| 99 |
5.4.99.5 |
Chorismate mutase |
CHMU_ENTAG |
2AO2 |
Chorismate mutase II |
Secreted chorismate mutase-like |
PubMed |
Two distinct structural folds |
| 5.4.99.5 |
Chorismate mutase |
CHMU_BACSU |
1COM |
Bacillus chorismate mutase-like |
Chorismate mutase |
PubMed |
| 100 |
5.5.1.1 |
Muconate cycloisomerase |
CATB_PSEPU |
1MUC |
TIM beta/alpha barrel & Enolase N-terminal domain |
D-glucarate dehydratase-like |
PubMed |
Two distinct structural folds |
| 5.5.1.1 |
Muconate cycloisomerase |
MLE_TRICU |
1JOF |
7-bladed beta-propeller |
WD40/YVTN repeat |
PubMed |
| 101 |
5.99.1.2 |
DNA topoisomerase |
TOP1_ECOLI |
1CY1 |
Prokaryotic type I DNA topoisomerase |
Prokaryotic type I DNA topoisomerase |
PubMed |
Two distinct structural folds |
| 5.99.1.2 |
DNA topoisomerase |
TOP1_HUMAN |
1LPQ |
DNA-breaking-rejoining enzymes |
Eukaryotic DNA topoisomerase I |
PubMed |
| 102 |
6.1.1.6 |
Lysine-tRNA ligase |
SYK1_ECOLI |
1BBU |
Class II aaRS and biotin synthetases |
Class II aminoacyl-tRNA synthetase |
PubMed |
Two distinct structural folds |
| 6.1.1.6 |
Lysine-tRNA ligase |
SYK_PYRHO |
1IRX |
Adenine nucleotide alpha hydrolase |
Class I lysyl-tRNA synthetase |
PubMed |
| 103 |
6.1.1.14 |
Glycine-tRNA ligase |
SYGA_ECOLI SYGB_ECOLI |
1J5W |
Class II aaRS and biotin synthetases |
Glycyl-tRNA synthetase, alpha and beta subunits |
PubMed |
Same fold, same superfamily |
| 6.1.1.14 |
Glycine-tRNA ligase |
SYG_HUMAN |
1ATI |
Class II aaRS and biotin synthetases |
Class-II aminoacyl-tRNA synthetase |
PubMed |
| 104 |
6.3.2.2 |
Glutamate-cysteine ligase |
GSH1_ECOLI |
1VA6 |
Glutamine synthetase/ guanido kinase |
Glutamate-cysteine ligase |
PubMed |
Predicted same fold |
| 6.3.2.2 |
Glutamate-cysteine ligase |
GSH1_HUMAN |
N/A |
Glutamine synthetase (predicted) |
Glutamate-cysteine ligase |
PubMed |
| 105 |
6.3.2.3 |
Glutathione synthase |
GSHB_ECOLI |
1GSA |
PreATP-grasp domain & ATP-grasp |
Prokaryotic glutathione synthetase |
PubMed |
Same fold, same superfamily, circular permutation |
| 6.3.2.3 |
Glutathione synthase |
GSHB_HUMAN |
2HGS |
PreATP-grasp domain & ATP-grasp |
Eukaryotic glutathione synthetase |
PubMed |