Table 1. Dissimilar enzymes catalyzing same biochemical reactions

A WWW supplement to the article by Michael Y. Galperin, D. Roland Walker and Eugene V. Koonin
"Analogous enzymes: Independent inventions in enzyme evolution", published in Genome Research, vol. 8, pp. 779-790. Free full text
(The paper and the table are to be updated by the end of 2007)

No.
Taxonomic representation
PDB hits Homologous enzymes with different enzymatic activities (EC No., example); comments
Gram-negative bacteria Gram-positive bacteria Archaea Eukaryotes
1. Alcohol dehydrogenase NAD-dependent (EC 1.1.1.1)
1 Ec:ADHE_ECOLI
Hi:-
Hp:HP0056
Sy:sll1561
Bsub:GbsB
Mgen:-
Mpne:
Mtub:5271086
ot:ADHE_CLOAB
Mjan:MJ1411
Mthe:MTH984
Aful:AF0024
Sulf:
Yeast:ADH4_YEAST
Celeg:121630
Human:435487
Plant:P5CS_VIGAC
ot:U04863
   
2 Ec:ADHP_ECOLI  
Hi:ADH3_HAEIN
Hp:HP1104
Sy:sll0990
Bsub:GutB
Mgen:-
Mgen:-
Mpne:MP278
Mtub:
ot:ADH3_BACST
Mjan:--
Mthe:-
Aful:AF2101
Sulf:ADH1_SULSO
Yeast:FADH_YEAST
Celeg:U18781
Human:ADHA_HUMAN
Plant:ADH_ARATH
ot:ADH_ANAPL
1HDZ 1DEH 2OHX 1HDX 1HDY Zn-containing dehydrogenases:  
Formaldehyde dehydrogenase (EC 1.2.1.1, FADH_YEAST)  
Rossmann fold
3 Ec:FABG_ECOLI
Hi:FABG_HAEIN
Hp:HP0557
Sy:slr0886
Bsub:FabG
Mgen:-
Mpne:-
Mtub:
ot:ACT3_STRCO 
Mjan:--
Mthe:-
Aful:-
Sulf:
Yeast:YNL202w
Celeg:1171506
Human:PGDH_HUMAN  Plant:S57614
ot:ADHR_DROGU
  Short-chain dehydrogenases:  
3-keto-ACP reductase (EC 1.1.1.100, FABG_ECOLI),  
glucose dehydrogenase (EC 1.1.1.47, DHG_BACSU)
2. Alcohol dehydrogenase NADP-dependent (EC 1.1.1.2)
4 Ec:TDH_ECOLI
Hi:ADH3_HAEIN
Hp:HP2383R
Sy:sll0990
Bsub:AdhB
Mgen:-
Mpne:MP278
Mtub:2225965
ot:ADH_THEBR
ot:ADH_CLOBE
Mjan:--
Mthe:-
Aful:AF2101
Sulf:ADH3_SULSO 
Yeast:DHSO_YEAST
Celeg:R04B5.5
Human:DHSO_HUMAN
Plant:ADH1_PEA
ot:ADH1_ENTHI 
1DEH 1HDZ 1TEH 1HTB 1HUD 1SDG 2OHX Zn-containing dehydrogenases  
Rossmann fold
5 Ec:YAFB_ECOLI
Hi:-
Hp:HP1193
Sy:slr0942
Bsub:YtbE
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:YHQ4_YEAST
Celeg:T08H10.1
Human:ALDX_HUMAN
Plant:ALDR_HORVU
2ALR 1DLA 1ADS 1ABN 1FRB 2ACU Aldo/keto reductase family
3. L-lactate dehydrogenase (EC 1.1.1.27)
6 Ec:YBIC_ECOLI
Hi:YIAK_HAEIN
Hp:-
Sy:-
ot: LDH_ALCEU
Bsub:YjmC
Mgen:-
Mpne:-
Mtub:
Mjan:MDH_METJA
Mthe:MTH1205
Aful:-
Sulf:
ot:MDH_METFE 
Yeast:-
Celeg:
Human:
Plant:
  Archaebacterial malate dehydrogenase family  
Malate dehydrogenase (EC 1.1.1.37, MDH_METFE)
7 Ec:mdh
Hi:HIN0619
Hp:-
Sy:sll0891
Bsub: LDH_BACSU
Mgen:MG460
Mpne:MP168
Mtub:
Mjan:MJ0490
Mthe:35960162
Aful:AF5468L
Sulf:
ot:MDH_HALMA
Yeast:YKL085w
Celeg:1078878
Human:LDHM_HUMAN
Plant:LDHA_HORVU 
1LLC 9LDB 5LDH 1LDM 1LDN 1LLD Malate dehydrogenase (EC 1.1.1.37, MDH_BACSU)
4. D-lactate dehydrogenase (EC 1.1.1.28)
8 Ec:DLD_ECOLI
Hi:LDHD_HAEIN
Hp:
Sy:
Bsub:-
Mgen:-
Mpne:
Mtub:
Mjan:-
Mthe:
Aful:2649802
Sulf:
Yeast:-
Celeg:
Human:
Plant:
  Glycolate oxidase subunit D (GLCD_ECOLI) 
9 Ec:LDHD_ECOLI
Hi:DDH_HAEIN
Hp:HP0397
Sy:slr1556  
ot:DDH_ZYMMO 
Bsub:SERA_BACSU
Mgen:-
Mpne:-
Mtub:
ot:LDHD_LACPL
ot:VANH_ENTFC
Mjan:MJ1018
Mthe:29468887
Aful:AF2012L
Sulf:
Yeast:SERX_YEAST
Celeg:1749578
Human:
Plant:DHGY_CUCSA 
2DLD 1PSD 2NAC 1GDH Fold: Flavodoxin-like
Glycerate dehydrogenase (EC 1.1.1.29, DHGY_HYPME)
3-phosphoglycerate dehydrogenase (EC 1.1.1.95, SERA_BACSU)
5. Malate dehydrogenase (EC 1.1.1.37)
10 Ec:YBIC_ECOLI
Hi:YIAK_HAEIN
Hp:-
Sy:-
ot:LDH_ALCEU 
Bsub:YjmC
Mgen:-
Mpne:-
Mtub:
Mjan:MDH_METJA
Mthe:3460662
Aful:-
Sulf:
ot:MDH_METFE
Yeast:-
Celeg:F13D12.1
Human:
Plant:
 
Archaebacterial malate dehydrogenase family
L-lactate dehydrogenase (EC 1.1.1.27, LDH_ALCEU)
11 Ec:mdh
Hi:HIN0619
Hp:-
Sy:sll0891
Bsub: LDH_BACSU
Mgen:MG460
Mpne:MP168
Mtub:
Mjan:MJ0490
Mthe:35960162
Aful:AF5468L
Sulf:
ot:MDH_HALMA
Yeast:-
Celeg:1078878
Human:LDHM_HUMAN  
Plant:LDHA_HORVU 
9LDB 5LDH 1LDM 1HLP L-lactate dehydrogenase (EC 1.1.1.27, LDH_BACSU)
6. Isocitrate dehydrogenase (EC 1.1.1.42)
12 Ec:IDH_ECOLI
Hi:LEU3_HAEIN
Hp:HP4718R
Sy:slr1289  
ot:IDH1_VIBA1 
Bsub: IDH_BACSU
Mgen:-
Mpne:
Mtub:
ot:IDH_THETH
Mjan:IDH_METJA
Mthe:5348202
Aful:AF4246L
Sulf:
ot:1592302
Yeast:IDH1_YEAST
Celeg:1523930
Human:IDHA_HUMAN
Plant:LEU3_SOLTU 
1ISO 6ICD 1GRO 1IDD 1XAC 1IDM Isopropylmalate dehydrogenase (EC 1.1.1.85, LEU3_NEUCR)
13  Ec:-
Hi:-
Hp:-
Sy:-
ot:IDH_AZOVI
Bsub:-
Mgen:-
Mpne:-
Mtub:
ot:ICD_CORGL
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant:
   
7. Glucose 1-dehydrogenase (EC 1.1.1.47)
14 Ec:KDUD_ECOLI
Hi:FABG_HAEIN
Hp:HP7120L
Sy:slr0886
Bsub: DHG_BACSU
Mgen:-
Mpne:-
Mtub:Y07E_MYCTU 
Mjan:-
Mthe:-
Aful:AF4128R
Sulf:
Yeast:FOX2_YEAST  
Celeg:1301670
Human:DHB4_HUMAN
Plant:FABG_CUPLA 
1YBV Short-chain dehydrogenases:
3-keto-ACP reductase (EC 1.1.1.100, FABG_ECOLI);
2-deoxygluconate dehydrogenase EC 1.1.1.125 KDUD_ERWCH)  
Rossman fold
15 Ec:ADH3_ECOLI
Hi:ADH3_HAEIN
Hp:
Sy:sll0990
Bsub:YycR
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
ot:DHG_THEAC
Yeast:ADH3_YEAST  Celeg:1263478
Human:ADHA_HUMAN  ot:ADH1_RANPE
1HDX 1HDY 1HDZ  Zn-containing dehydrogenases:
alcohol dehydrogenase (EC 1.1.1.1, ADHA_UROHA)  
Rossman fold (Same RMSD=3.7)
8. 3-Alpha-hydroxy-steroid dehydrogenase (EC 1.1.1.50)
16 Ec:YJGI_ECOLI
Hi:FABG_HAEIN
Hp:HP7120L
Sy:slr2124
ot:JN0829 
Bsub:DHG_BACSU
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:AF4128R
Sulf:
Yeast:SP19_YEAST  Celeg:W01C9.4
Human:S66665
Plant:
1AHH 1AHI 1CYD Rossman fold
17 Ec:YQHE_ECOLI
Hi:-
Hp:-
Sy:slr0942
Bsub:YvgN
Mgen:-
Mpne:-
Mtub:1694860
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:YHQ4_YEAST  Celeg:ZC443.1
Human:1815604
ot:DIDH_RAT
1RAL 1AFS 1DLA 1ABN 1FRB TIM-barrel
9. 17-Beta-hydroxy-steroid dehydrogenase (EC 1.1.1.62)
18 Ec:YOHF_ECOLI
Hi:FABG_HAEIN
Hp:HP1464L
Sy:slr0315
Bsub:YusZ
Mgen:-
Mpne:
Mtub:Y04M_MYCTU 
Mjan:-
Mthe:
Aful:AF4128R
Sulf:
Yeast:YMR226c
Celeg:
Human:DHB1_HUMAN
Plant:
1FDS 1BHS 1IOL Short-chain dehydrogenases
Rossmann fold
19 Ec:YAFB_ECOLI
Hi:
Hp:-
Sy:slr0942
Bsub:YvgN
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:GCY_YEAST
Celeg:1707239
Human:DBDD_HUMAN  Plant:6DCS_SOYBN  
ot:A56424
1AFS 1RAL 1DLA 1ADS 1FRB TIM-barrel fold
10. Formate dehydrogenase (EC 1.2.1.2)
20 Ec:FDHF_ECOLI
Hi:BISC_HAEIN
Hp:HP5225L
Sy:sll1454  
ot:S18213
Bsub:YjgC
Mgen:-
Mpne:-
Mtub:YX31_MYCTU
Mjan:MJ0005
Mthe:S63554
Aful:AF7266L
Sulf:
ot:FDHA_METFO
Yeast:
Celeg:
Human:
Plant:
1AA6 Nitrate reductase (EC 1.7.99.4, NASC_BACSU),
dimethyl sulfoxide reductase (DMSA_ECOLI)
21 Ec:SERA_ECOLI
Hi:SERA_HAEIN
Hp:HP6358L
Sy:1653783  
ot:FDH_PSESR 
Bsub:SerA
Mgen:-
Mpne:-
Mtub:
ot:1477947
Mjan:MJ1018
Mthe:29468887
Aful:AF2012L
Sulf:
Yeast:YOR388c
Celeg:1749578
Human:
Plant:FDH_SOLTU
ot:FDH_NEUCR FDH_HANPO
2NAC 2NAD 1DLD Glycerate dehydrogenase (EC 1.1.1.29, DHGY_HYPME),
3-phosphoglycerate dehydrogenase (EC 1.1.1.95, SERA_BACSU)  
Fold: Flavodoxin-like  
11. Carbon monoxide dehydrogenase (EC 1.2.99.2)
22 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:
Mtub:
ot: DCMA_CLOTH
Mjan:MJ0152
Mthe:9964715
Aful:AF7175R
Sulf:
ot:1575540
Yeast:-
Celeg:-
Human:-
Plant:
 
  DCMA_CLOTH is Ni-dependent; DCMB_CLOTH is similar to DCMA_METSO and other FeS center-containing proteins 
23 Ec:1786478
Hi:-
Hp:-
Sy:-
ot:C56279 
Bsub:YurC
Mgen:-
Mpne:
Mtub:
Mjan:-
Mthe:
Aful:
Sulf:1707756
Yeast:-
Celeg:1731954 Human:ADO_HUMAN
Plant:
ot:XDH_HUMAN
1ALO Nicotine dehydrogenase (EC 1.5.99.4); aldehyde oxidase (EC 1.2.3.1); xanthine dehydrogenase (EC 1.1.1.204)
12. Protochlorophyllide reductase (EC 1.3.1.33)
24 Ec:-
Hi:-
Hp:-
Sy: CHLN_SYNY3  
ot:BCHN_RHOCA 
Bsub:-
Mgen:-
Mpne:
Mtub:
Mjan:-
Mthe:20942825
Aful:-
Sulf:
ot 
Yeast:-
Celeg:-
Human:-
Plant:CHLN_PINCO
ot:CHLN_CHLRE
ot:CHLN_MARPO
3MIN  1MIO Light-independent form is found in cyanobacteria and chloroplasts of all plants, except angiosperms
Nitrogenase Fe-Mo fold
25 Ec:-
Hi:-
Hp:
Sy:slr0506
Bsub:YxbG
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:YMR226c
Celeg:1703589
Human:DHCA_HUMAN  
Plant: PCR_ARATH PCR_PEA
1FDS Light-dependent form, is nuclear-encoded, found in cyanobacteria and chloroplasts of angiosperms
Rossmann fold
13.Dihydrofolate reductase (EC 1.5.1.3)
26 Ec:DYRA_ECOLI
Hi:DYRA_HAEIN
Hp:-
Sy:-
Bsub: DYR_BACSU
Mgen:MG228
Mpne:MP517
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
ot:DYR_HALVO
Yeast:DYR_YEAST
Celeg:1546725
Human:DYR_HUMAN
Plant:DYR_SOYBN
ot:DRTS_PLAFK
1DHJ 4DFR 5DFR 1RA9  
27 Ec:DYR2_ECOLI
Hi:-
Hp:-
Sy:-
ot:DYR3_ECOLI 
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:
Aful:
Sulf:
Yeast:-
Celeg:-
Human:-
Plant:
1VIE Plasmid-encoded methotrexate resistance gene
14. NADH dehydrogenase (EC 1.6.99.3)
28 Ec:NUOF_ECOLI
Hi:-
Hp:-
Sy:sll1221
ot:NQO1_PARDE 
Bsub:-
Mgen:-
Mpne:-
Mtub:1781218
Mjan:-
Mthe:24428454
Aful:-
Sulf:
Yeast:-
Celeg:908831
Human:NUBM_HUMAN Plant:S52261
ot:NUBM_NEUCR
   
29 Ec:TRXB_ECOLI
Hi:TRXB_HAEIN
Hp:HP1184R
Sy:slr1849
ot:AHPF_SALTY 
Bsub:DNHA_BACSU
Mgen:MG102
Mpne:MP592
Mtub:TRXB_MYCTU
ot:DHNA_BACSP
Mjan:MJ1536
Mthe:5111643
Aful:AF2819L
Sulf:
Yeast:YDR353w
Celeg:1226269
Human:
Plant:
1VDC 1TDE 1TDF 1TRB  
15. Diphenol (polyphenol) oxidase (EC 1.10.3.1)
30 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:SUN2_YEAST 
Celeg:DXA2_CAEEL
Human:
Plant:JQ2257
ot:DXA2_DROME
   
31 Ec:-
Hi:-
Hp:-
Sy:-
ot:TYRO_RHIME 
Bsub:-
Mgen:-
Mpne:-
Mtub:
ot:TYRO_STRAT
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant: PPO_SPIOL PPOA_LYCES
1LLA 1OXY 1HC1 Monophenol monooxygenase (EC 1.14.18.1, TYRO_STRAT)
16. Cytochrome c peroxidase (EC 1.11.1.5)
32 Ec:YHJA_ECOLI
Hi:-
Hp:HP4015R
Sy:-
ot:CCPR_PSESP 
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant:
   
33 Ec:CATA_ECOLI
Hi:-
Hp:-
Sy:sll1987  
ot:CATA_RHOCA 
Bsub:-
Mgen:-
Mpne:-
Mtub:CATA_MYCTU
ot:CATA_BACST
Mjan:-
Mthe:-
Aful:AF0388L
Sulf:
Yeast:CCPR_YEAST
Celeg:
Human:
Plant:APX1_PEA 
2CYP 1CCA 1CCP 1CCB Catalase (1.11.1.6, CATA_ARATH)  
Fold: Heme-dependent peroxidases
17. Catalase (EC 1.11.1.6)
34 Ec:CATA_ECOLI
Hi:-
Hp:-
Sy:sll1987  
ot:CATA_RHOCA 
Bsub: -
Mgen:-
Mpne:-
Mtub:CATA_MYCTU
ot: CATA_BACST
Mjan:-
Mthe:-
Aful:AF0388L
Sulf:
Yeast:CCPR_YEAST
Celeg:
Human:
Plant:APX1_PEA 
2CYP 1CCA 1CCP 4CCX 1RYC Catalase HPI,  
Fold: Heme-dependent peroxidases
35 Ec:CATE_ECOLI
Hi:CATA_HAEIN
Hp:HP1389L
ot:CATA_BORPE
Sy:-
Bsub:CATV_BACSU
Mgen:-
Mpne:-
ot:CATB_BACSU
ot:CATE_MYCAV
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:CATA_YEAST  Celeg:S49452
Human:CATA_HUMAN
Plant:CAT1_TOBAC
ot:CATA_DROME
2CAH 7CAT 1RYC 1APX 1IPH Catalase HPII
36 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:YdbD
Mgen:-
Mpne:-
Mtub:
ot: 1752756
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant:
   
18. Peroxidase (EC 1.11.1.7)
37 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:
Celeg:1067049
Human:PERM_HUMAN
Plant:
ot:PERO_DROME
1MYP 1MHL  
38 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:
Celeg:
Human:
Plant: PERX_SOLTU PER1_HORVU
1SCH 4CCP 1BGP 2CYP 1RYC  Same fold RMSD=4.9
19. Chloroperoxidase (EC 1.11.1.10)
39 Ec:1786545
Hi:-
Hp:-
Sy:slr0314
ot:PRXC_PSEPY
Bsub:YisY
Mgen:-
Mpne:-
Mtub:-
ot:PRXC_STRLI BPA1_STRAU
Mjan:-
Mthe:-
Aful:AF5437R
Sulf:
Yeast:YNR064c
Celeg:K07C5.5
Human:HYES_HUMAN  Plant:1304227 
1BRO Bromoperoxidase (EC 1.11.1.-, BPA1_STRAU)
Epoxide hydrolase (EC 3.3.2.3, HYES_RAT)
40 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant:
ot:PRXC_CALFU
2CPO  
41 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:
Celeg:
Human:
Plant:
ot:PRXC_CURIN
1VNC Vanadium chloro-peroxidase
20. Alkane 1-monooxygenase (EC 1.14.15.3)
42 Ec:-
Hi:-
Hp:-
Sy:-
ot:ALKB_PSEOL 
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:-
Human:-
Plant:
   
43 Ec:-
Hi:-
Hp:-
Sy:slr0574
Bsub:YrhJ
Mgen:-
Mpne:-
Mtub:-
ot:CPXB_BACME
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:ERG5_YEAST
Celeg:1403284
Human:CP4B_HUMAN
Plant:CP78_MAIZE
2BMH 2HPD 1FAH  
21. Superoxide dismutase (EC 1.15.1.1)
44 Ec:SODC_ECOLI
Hi:SODC_HAEIN
Hp:-
Sy:
ot:SODC_CAUCR 
Bsub:YojM
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:SODC_YEAST
Celeg:SODC_CAEEL  
Human:SODC_HUMAN
Plant:SODP_SPIOL SODP_PINSY
1SRD 1COB 2SOD 3SOD Cu/Zn SODs are found in bacteria, chloroplasts and cytoplasm of eukaryotic cell
45 Ec:SODF_ECOLI
Hi:SODM_HAEIN
Hp:SODF_HELPY
Sy:slr1516
ot:SODF_PSEAE
Bsub:SODM_BACSU
Mgen:-
Mpne:-
Mtub:SODF_MYCTU
ot:SODM_CORDI
Mjan:-
Mthe:SODF_METTH
Aful:-
Sulf:SODF_SULAC
ot:SODM_HALHA
Yeast:SODM_YEAST
Celeg:SODM_CAEEL
Human:SODM_HUMAN
Plant:SODF_ARATH
SODP_MAIZE
ot:SODF_ENTHI 
1ABM 1IDS 1ISA 3SDP 3MDS Mn/Fe SODs are found in bacteria and archaea; in eukaryotes, in mitochondria and chloroplasts only
22. Ribonucleoside triphosphate reductase (EC 1.17.4.2)
46 Ec:RIR1_ECOLI
Hi:RIR1_HAEIN
Hp:-
ot:RIR1_SALTY
Sy:1653420
Bsub:-
Mgen:-
Mpne:S73838
Mtub:  
ot: 308869 
Mjan:-
Mthe:33756317
Aful:AF2435R
Sulf:  
ot: 1657993
Yeast:RIR1_YEAST
Celeg:RIR1_CAEEL
Human:RIR1_HUMAN
Plant:  
ot:RIR1_DROME
1RLR Ribonucleoside-diphosphate reductase (EC 1.17.4.1, RIR1_YEAST);
Viral protein VG50_BPML5; 
47 Ec:NRDD_ECOLI
Hi:NRDD_HAEIN
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:MJ0832
Mthe:26254387
Aful:
Sulf:
Yeast:-
Celeg:
Human:
Plant:
  Viral protein NRDD_BPT4
23. Hydrogenase (EC 1.18.99.1)
48 Ec:NUOG_ECOLI
Hi:-
Hp:HP3142R
ot:PHFL_DESVH
Sy:sll1223
Bsub:YrhE
Mgen:-
Mpne:-
Mtub:
ot:PHF1_CLOPA
Mjan:MJ1303
Mthe:S57430
Aful:AF6863L
Sulf:
ot:FDHA_METFO 
Yeast:YNY0_YEAST  Celeg:459011
Human:NUAM_HUMAN  Plant:
ot:1171117
1FCA 1CLF  
49 Ec:MBHM_ECOLI
Hi:-
Hp:HP0332R
Sy:sll1226  
ot:PHNL_DESVM 
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:MJ0029
Mthe:FRHA_METTH
Aful:AF3480R
Sulf:
ot:S49929
Yeast:-
Celeg:
Human:
Plant:
1FRV Coenzyme F420 hydrogenase (EC 1.12.99.1, FRHA_METVO)
24. Phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17)
50 Ec:YIGO_ECOLI
Hi:Y912_HAEIN
Hp:HP6458L
Sy:sll1407  
ot:PMTA_RHOSH 
Bsub:GRC2_BACSU
Mgen:-
Mpne:-
Mtub:
Mjan:MJ1123
Mthe:
Aful:AF8050L
Sulf:
ot:1124958
Yeast:-
Celeg:
Human:
Plant:
1AQI 1XVA 1AQJ In eukaryotes, sim only to a chloroplast protein(1419090)
51 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:
Aful:
Sulf:
Yeast:PEM1_YEAST
Celeg:
Human:
Plant:
   
25. Glycerol-3-phosphate O-acyltransferase (EC 2.3.1.15)
52 Ec:PLSB_ECOLI
Hi:PLSB_HAEIN
Hp:-
Sy:1652152
Bsub:ThdF
Mgen:-
Mpne:-
Mtub:Y04E_MYCTU 
Mjan:-
Mthe:
Aful:
Sulf:
Yeast:-
Celeg:F08F3.2
Human:
Plant:
ot:A41672
  1-Acyl-sn-glycerol-3-phosphate acyltransferase (EC 2.3.1.51, PLSC_ECOLI)
53 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:
Sulf:
Yeast:-
Celeg:
Human:
Plant: PLSB_CUCMO PLSB_PEA
   
26. Chloramphenicol acetyltransferase (EC 2.3.1.28)
54 Ec:CAT_ECOLI
Hi:CAT2_HAEIN
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:-
Mtub:-
ot: CAT_STRAC CAT1_STAAU
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant:
1CLA 1QCA 4CLA 1CIA  
55 Ec:CAT4_ECOLI
Hi:-
Hp:-
Sy:sll1900
ot:CAT4_AGRTU
Bsub:YyaI
Mgen:-
Mpne:
Mtub:-
Mjan:MJ1064
Mthe:33881910
Aful:-
Sulf:
Yeast:YJV8_YEAST
Celeg:
Human:
Plant:
1LXA 1THJ Galactoside O-acetyltransferase (EC 2.3.1.18, THGA_ECOLI)
27. Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43)
56 Ec:-
Hi:-
Hp:-
Sy:-
ot:GCAT_AERHY 
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant:
  Phospholipase A2 HLT_VIBPA;
lipase (EC 3.1.1.3, LIP1_PHOLU);
57 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:
Mtub:-
ot:1017754
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:YN84_YEAST  Celeg:1279319
Human:LCAT_HUMAN
Plant:
ot:LCAT_CHICK
   
N-terminal acetyltransferase (EC 2.3.1.88)
 
-
YAD5-CLOAB
MJ0263
Yeast:NAT1_YEAST   These two enzymes differ in substrate specificity and should have been assigned different EC numbers
-
-
-
Yeast:NAT2_YEAST  
28. Protein-glutamine-gamma-glutamyl transferase (EC 2.3.2.13)
58 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:
Mtub:-
ot: JC2089
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant:
  Activity of the 3-d type of gamma-glutamyltransferase (L48925) has not been shown experimentally
59 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:
Mgen:-
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:TGLK_HUMAN
Plant:
ot: TGLK_RABIT
1GGT 1FIE Coagulation factor XIII
(F13A_HUMAN)
29. 4-Alpha-glucanotransferase (EC 2.4.1.25)
60 Ec:MALQ_ECOLI
Hi:MALQ_HAEIN
Hp:-
Sy:sl1676
Bsub:
Mgen:-
Mpne:
Mtub:-
ot:MALQ_STRPN
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant: DPEP_SOLTU
   
61 Ec:TREC_ECOLI
Hi:GLGX_HAEIN Hp:-
Sy:sll0842  
ot:S60618
Bsub:TreA
Mgen:-
Mpne:
Mtub:-
ot:DEXB_STRMU
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:MA1S_YEAST  Celeg:527426
Human:GDE_HUMAN
Plant:AMY3_WHEAT  ot:GDE_RABIT AMY3_DICTH 
1PAM 1CIU 1TCM 1CGV 1CGW 1CXF 1CGT Alpha-amylase (EC 3.2.1.1, AMY_BACSU); maltase (EC 3.2.1.20, MA6S_YEAST); cyclomaltodextrin glucano-transferase(EC 2.4.1.19, CDGT_BACST)
NAD-diphtamide ADP-ribosyltransferase (EC 2.4.2.36)
  Ec:-
Hi:-
Hp:-
Sy:-
Bsub:-
Mgen:-
Mpne:-
Mtub:-
ot:DTX_CORBE
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant:
ot:CHCB_BOMMO
1DDT 1DTP Enterotoxin TOXA_PSEAE
  Ec:ELAP_ECOLI
Hi:-
Hp:-
Sy:-
ot:CHTA_VIBCH 
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:--
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant:
1XTC 1LTA 1LTB Pertussis toxin TOX1_BORPE  
Same fold, RMSD=3.5
30. Glutathione S-transferase (EC 2.5.1.18)
62 Ec:GT_ECOLI
Hi:GT_HAEIN
Hp:-
Sy:sll0067
ot:1050750 
Bsub:
Mgen:-
Mpne:-
Mtub:
Mjan:--
Mthe:-
Aful:-
Sulf:
Yeast:URE2_YEAST
Celeg:967036
Human:GTT1_HUMAN
Plant: GTH1_WHEAT
ot:JC5114 GTT1_DROME
1GSE 1GUH 1AGS  
63 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:
Mgen:-
Mpne:-
Mtub:
Mjan:--
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:GTMI_HUMAN
Plant:
ot:GTMI_RAT
   
31. Alanine-glyoxylate aminotransferase (EC 2.6.1.44)
64 Ec:-
Hi:-
Hp:HP0818L
Sy:sll1559  
ot:DHSS_ANACY 
Bsub:YurG
Mgen:-
Mpne:-
Mtub:SERC_MYCTU
Mjan:MJ0959
Mthe:F2_276
Aful:AF3320R
ot:JC2256
Sulf:
Yeast:YFD0_YEAST  Celeg:T14D7.1
Human:SPYA_HUMAN
Plant:
ot:SPYA_RABIT
1AAW 1ASL 1ASM 1AJS In eukaryotes, this enzyme is found in mitochondria and peroxisomes  
Same fold, RMSD=4.1
65 Ec:GABT_ECOLI
Hi:Y949_HAEIN
Hp:HP1845L
Sy:slr1022
Bsub:YhxA
Mgen:-
Mpne:-
Mtub:1478223
ot:YKAB_BACFI  GABT_MYCLE
Mjan:MJ0721
Mthe:C2_813
Aful:AF8244L
Sulf:
ot:1127769 
Yeast:OAT_YEAST
Celeg:1707274
Human:1093492
Plant:
ot:1000448
1DGD 2DKB Dialkylglycine decarboxylase (EC 4.1.1.64, DGDA_BURCE);
Gamma-aminobutyrate aminotransferase (EC 2.6.1.19, GABT_ECOLI) This enzyme was found in rat kidney mitochondria
32. Glucokinase (EC 2.7.1.2)
66 Ec:HXKG_ECOLI
Hi:YAJF_HAEIN
Hp:HP2377R
Sy:sll0593  
ot:HXKG_ZYMMO 
Bsub:-
Mgen:-
Mpne:-
Mtub:
Mjan:--
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant:
  Common motif
67 Ec:YHCI_ECOLI
Hi:YHCI_HAEIN
Hp:-
Sy:slr0329
Bsub:YqgR
Mgen:-
Mpne:-
Mtub:-
ot: GLK_STRCO
Mjan:-
Mthe:-
Aful:AF1312R
Sulf:
Yeast:-
Celeg:
Human:
Plant:
  Fructokinase (EC 2.7.1.4, SCRK_PEDPE) This group has a common motif with the previous one
68 Ec:-
Hi:-
Hp:-
Sy:-
Bsub:-
Mgen:
Mpne:-
Mtub:
Mjan:-
Mthe:-
Aful:-
Sulf:
Yeast:HXKG_YEAST
Celeg:F14B4.2
Human:HXK1_HUMAN
Plant:S71205
ot: 1619590 HXK_PLAFA 
1HKG 2YHX Fold: Ribonuclease H-like motif
33. Fructokinase (EC 2.7.1.4)
69 Ec:SCRK_ECOLI
Hi:KDGK_HAEIN
Hp:-
Sy:slr1448  
ot:KDGK_ECOLI 
Bsub:YdjE
Mgen:-
Mpne:-
Mtub:1666148
Mjan:MJ0406
Mthe:C2_1008
Aful:AF7085L
Sulf:1706952 
Yeast:RBSK_YEAST  Celeg:F07A11.5
Human:KHK_HUMAN
Plant: SCRK_SOLTU
   
70 Ec:-
Hi:-
Hp:-
Sy:-
ot:SCRK_ZYMMO 
Bsub:YdhR
Mgen:-
Mpne:-
Mtub:1877388
ot:SCRK_STRMU
Mjan:--
Mthe:-
Aful:-
Sulf:
Yeast:-
Celeg:
Human:
Plant:
  Glucokinase (EC 2.7.1.2, GLK_STRCO) 
34. 6-Phosphofructokinase (EC 2.7.1.11)
71 Ec:K6P1_ECOLI
Hi:K