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NCBI books is a repository for freely accessible, full-text biomedical books. PubMed abstracts provide a quick method to search for terms located in NCBI books. To begin the process, click on the "Books" link to the right.
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1: Science 2001 Oct 26;294(5543):853-8 Related Articles, Books, LinkOut
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Identification of Novel Genes Coding for Small Expressed RNAs.

Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T.

Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 Gottingen, Germany.

In Caenorhabditis elegans, lin-4 and let-7 encode 22- and 21-nucleotide (nt) RNAs, respectively, which function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as small temporal RNAs (stRNAs). We show that many 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates and that some of these novel RNAs, similar to let-7 stRNA, are highly conserved. This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.

PMID: 11679670 [PubMed - in process]