Making Sense of DNA and Protein
Sequences: an Interactive NCBI Mini-Course
Definition of CD: Conserved Domain. CD refers to a domain (a distinct functional and/or structural unit of a protein) that has been conserved during evolution. CDs are generated from multiple sequence alignments and may be refined by comparison to solved structures. During evolution, amino acid changes occur in ways that preserve the physico-chemical properties of critical residues, and hence the structural and/or functional properties of that domain.