- An annotated protein sequence database established in 1986 at the Department of Medical Biochemistry of the University of Geneva.
- Now maintained at the Swiss Institute of Bioinformatics (SIB) and the European Bioinformatics Institute (EBI).
- Minimal level of redundancy.
- High level of integration with other databases (currently cross-referenced with about 45 different databases).
- The database contains two types of classified data:
- SWISS-PROT STANDARD (complete and up to the standards of annotation)
- Core data (sequence data, bibliographical references, taxonomic data (biological source of protein).
- Annotated data
- Function(s) of the protein.
- Posttranslational modification(s)(e.g., carbohydrates, phosphorylation, etc.).
- Domains and sites (e.g.,calcium-binding regions, ATP-binding sites, zinc fingers, homeoboxes, etc.).
- Secondary structure (e.g., alpha helix, beta sheet, etc.).
- Quaternary structure(e.g., homodimer, heterotrimer, etc.).
- Similarities to other proteins.
- Disease(s) associated with any number of deficiencies in the protein.
- Sequence conflicts, variants, etc.
- PRELIMINARY Sequence entries are distributed with a supplement called TrEMBL (Translations of EMBL);
- Computer-annotated supplement to SWISS-PROT.
- Sequences which have not yet been annotated by the SWISS-PROT staff up to the standards of annotation.
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