Practice User Question : Displaying Both Human and Mouse Maps
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| Sample User Question
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Find the human gene for Huntington’s Disease (HD) in the Human MapViewer.
Display both the human and mouse maps simultaneously. In which
chromosomal region for each organism are the homologous HD genes
found? How similar/different are the mouse and human genes? Are any of
the other genes nearby also possibly homologous between the human and
the mouse?
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| Analysis / Comments
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The mouse, Mus Musculus, is an extremely useful model organism for studies in
genetics and the relationship of genes to disease. Mouse genes can be manipulated
successfully in the laboratory and the consequences to the living organism over
generations can be identified and tested. Also, the mouse genome has many
similarities to the human, in size, complexity, and number of genes. Most
mouse genes are approximately 80% sequence identical to their human homologues.
Now that both the human and mouse genomes have been sequences and can be compared,
sequences conserved by evolution between the two species can be identified and their
function determined.
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| Flow Chart |
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- Entrez Gene -
Use Entrez Gene to learn more about the gene of interest and make certain that you are choosing the
correct gene. Also, Entrez Gene provides a direct link to the MapView of the human genome sequence,
specifically to the location of the particular gene of interest. In the Homology subsection,
you can link to the Mapview of the human, mouse and rat gene simultaneously.
- Map Viewer -
The MapViewer provides a graphic view of the human genome as well as links to the full
sequence and the opportunity to download specific regions of the full sequence. Use the Maps
and Options dialog box to select which maps will be viewed.
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| Step By Step Guide |
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- Go to Entrez Gene and search for "huntington."
Click on the record accession # for the HD gene to see the full record.
- Click on the link to the MapViewer. You can use either the link in the
"Genomic context" section and then use 'Maps&Options" dialog box to add the mouse
map or you can scroll down to the "Homology" section and click on the link to
the MapViewer there which will provide both the mouse and rat along with the human
map automatically.
- Look at the resulting MapView.
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