Demonstration Question:
Homologene
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| Sample User Question
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Identify known homologs to EDN1 in other model organisms.
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| Analysis/Comments |
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Models of human genes and diseases in other organisms are a valuable source
of information regarding the biochemistry, physiology, pathology, genetics, and therapy of
the relationship between the gene and the disease. Some model organisms produce generations much faster than humans
while others have very similar physiology. Models in whom a specific gene has been mutated or
eliminated provide realms of data regarding the function and physiological effect of the protein
product that gene. Therefore, an understanding of the homology
between human genes and genes in these organisms is of great value. Given the rapidly accumulated
data on the genomes of other mammalian organisms, a lot can be learned from
the comparison of homologous genes between these organisms.
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| Flow Chart |
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- MapViewer - This allows you
to view the maps of the human genome and the genomic context for genes, along with links to multiple
other NCBI databases.
- Homologene -
This database provides information on homologous genes in multiple organisms.
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| Step By Step Guide |
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- Locate EDN1 in the MapViewer and select the "Genes_seq" map as the master map.
- Click on "hm" in the annotation of the EDN1 Genes_seq map.
- Click on the homologene record ID for EDN1.
- View the record which includes mRNAs and proteins for homologous genes
in several organisms as well as EST clusters suggesting the existence of a
homologue in more organisms for whom the gene has not yet been identified.
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