Genetics Review
PubMed Entrez BLAST OMIM Taxonomy Structure
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Course Description

Schedule

Introduction

Genetics Review

Types of Databases

Format of Sequence Record

Entrez

BLAST

3-D Structures

Genomes and Maps

Librarian Roles

WWW Sites

Glossaries and Dictionaries

 

Chromosome Banding and Nomenclature back to top

Cytogenetic Ideogram for human chromosome 18

Source:  image on left from the GeneMap'99 illustration of Chromosome 18. Image on right from the CCAP Web page on "Recurrent Aberration Data."

Definition back to top

Each human chromosome has a short arm ("p" for "petit") and long arm ("q" for "queue"), separated by a centromere. The ends of the chromosome are called telomeres.

Each chromosome arm is divided into regions, or cytogenetic bands, that can be seen using a microscope and special stains. The cytogenetic bands are labeled p1, p2, p3,   q1, q2, q3, etc., counting from the centromere out toward the telomeres. At higher resolutions, sub-bands can be seen within the bands. The sub-bands are also numbered from the centromere out toward the telomere.

For example, the cytogenetic map location of the CFTR gene is 7q31.2, which indicates it is on chromosome 7, q arm, band 3, sub-band 1, and sub-sub-band 2.

The ends of the chromosomes are labeled ptel and qtel. For example, the notation 7qtel refers to the end of the long arm of chromosome 7.

More... back to top

For more information on chromosome banding and chromosome nomenclature, see pp. 37-39 of:
Strachan, T. and Read, A.P. 1999. Human Molecular Genetics, 2nd ed. New York: John Wiley & Sons.

For more examples of chromosome band numbers, see the chromosome ideograms accessible from:

GeneMap'99 (click on a chromosome number).

The CCAP Web page on "Recurrent Aberration Data" (click on a chromosome number), based on a genome-wide map of chromosomal breakpoints in human cancer by Drs. Mitelman, Mertens, and Johansson.

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  Revised February 13, 2001
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