DNA transcription RNA translation PROTEIN

• Cell

• Nucleus

• Chromosome

• Genome
  • spectral karyotype

• DNA
  • DNA: detailed view

• Nucleotide
  • Base Pair
  • Nucleotide Base Codes (IUPAC abbreviations)

• DNA Replication

• Mitosis

• Gene  (including notes about exons, introns, and alternative splicing)
  • Transcription from DNA (4 bases) --> RNA (4 bases)
    • RNA: detailed view

  • Translation from mRNA (4 bases) --> protein (20 amino acids)
    • codon - three mRNA bases code for a single amino acid
    • genetic code
    • ~20 genetic codes in GenBank
    • reading frames

  • Protein
    • amino acid abbreviations (IUPAC)

  • Review: DNA --> mRNA --> protein

• Gene Control

• Gene Expression  (including notes on ESTs, cDNA, and Microarrays)
  • Gene Expression in different organs
  • Gene Expression in prostate cells (normal, precancerous, malignant)

• Mutations

• 3-Dimensional Protein Structures

• Genome Maps
  • cytogenetic map (and chromosome band numbers)
  • genetic map
  • physical maps
    • radiation hybrid map
    • clone-based map
    • sequence map

• A Few More Terms
  • acrocentric chromosome
  • euchromatin
  • heterochromatin
  • draft sequence
  • finished sequence

Access Excellence Graphics Gallery. Provides labeled illustrations of genetic concepts.

Biology Project, by the University of Arizona, features brief tutorials and corresponding problem sets on a variety of biology topics, including cell biology, human biology, Mendelian Genetics, molecular biology, and others. A sample problem in the Human Biology section is 'Web Karyotyping,' in which you play the role of a cytogenetic technician and complete three patient karyotypes, then evaluate and diagnose each patient. Another example of a feature that will be of interest is "The Cell Cycle & Mitosis Tutorial."

Blazing a Genetic Trail, by the Howard Hughes Medical Institute (HHMI), illustrates the significance of genetic research by recounting the discovery of the gene for cystic fibrosis. It also includes a link to a Brief Key to Basic Genetics.

Dolan DNA Learning Center is a unit of Cold Spring Harbor Laboratory, serving to provide public genetics education to college, pre-college, and the public. The Center serves as both a clearinghouse for information on DNA science, genetic medicine and biotechnology; and provides an interactive learning environment for students. These goals are reflected in the wealth of information provided at their web site.

Genes and Disease web site discusses how genetic factors contribute to human disease, and provides summary information for ~60 genetic diseases with links to related databases and organizations.

MIT Biology Hypertextbook is designed to supplement the course materials of MIT Introductory Biology 7.01. It contains a variety of components designed to be used independently or together to facilitate your understanding of introductory molecular biology.

National Human Genome Research Institute (NHGRI) provides Educational Resources for students, teachers, and the general public. It includes an introduction to the human genome project, a talking glossary, fact sheets, and multimedia educational kits on "Exploring Our Molecular Selves".

Science Primer, an NCBI resource that explains the science behind the molecular databases at the National Center for Biotechnology Information (NCBI). Topics include bioinformatics, genome mapping, molecular modeling, SNPs, ESTs, microarray technology, molecular genetics, pharmacogenomics, and phylogenetics.

Understanding Gene Testing, by Access Excellence, explores how genes are linked to disease and discusses the nature and uses of genetic testing.

US Department of Energy's Human Genome Project Information site includes links to a wide variety of educational resources, including a glossary, science primer, and wide variety publications, teaching aids, and online animations.