NMR and X-Ray Crystallography: Examples
Regardless of the method used, no protein structure is properly represented
by a single conformation. Every protein molecule has intrinsic motion and will
shift and change based on molecular properties and environmental conditions. Also,
the data used to generate the structure is never perfect. Therefore, a true
protein structure is actually a set of models. When you view a single
structure, you are actually viewing a single snapshot of the protein in time.
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| NMR Structure of Calmodulin (1DMO) showing 30 models. |
X-Ray Crystallography structure (3CLN) of Calmodulin. |
Source: slide from the Structure module, by Jennifer Lyon, of the 5-day NCBI Advanced Workshop for Bioinformatics Information Specialists
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