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Genomes and Maps
module of the MLA course on Introduction to Molecular Biology Information
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Sample Eukaryotic Genome

Homo sapiens

  • eukaryotic genomes generally have multiple, linear chromosomes
  • a more powerful graphical viewing software program, Map Viewer, is used to display a variety of eukaryotic genomes (from lower genomes such as yeasts to higher genomes such as human)
  • concept is still the same -- see overview of complete organism, then zoom into detailed view of region of interest -- just like in Map Quest

  • genome view page shows the organism's chromosomes, to scale, and also shows extrachromosomal DNA (for example, mitochondrial (MT) genome)
  • can search across genome or within a chromosome for all map objects that contain specific terms (e.g., colon cancer) in their descriptions
  • graphical display of search results (red tick marks show locations of map objects that contain query terms) is followed by a tabular summary
  • follow links for objects of interest to see the corresponding chromosome regions in detail on a map view page
  • options on the detailed chromosome views provide many ways to customize display
  • main Map Viewer help document (accessible from blue sidebar) describes how to use the software and its features such as customization; organism-specific help documents describe the data available for each organism
For now, we just took a quick look at a sample prokaryotic and eukaryotic genome, and saw how the display of a complete genome differs from the display of genome fragments (e.g., sequences for individual genes that we saw in our searches of Entrez Nucleotide). Later in the module, we'll search the human genome for some sample genes and work more with Map Viewer to understand its features and uses. Before we do that, let's look at how a genome is sequenced (next slide)...

Genomes and Maps
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Revised 11/07/2007