Problem Summary:
Find concise summary of genes
pertaining to a specific area of research |
| Sample User Question |
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I have received a Request for Proposals on the topic of
circadian rhythms. I'd like to study the regulation of a gene important in
circadian rhythms, but I haven't decided which gene to follow. I went to
Entrez Nucleotide, entered "circadian" and found 668 references--too many!
Also, many entries are redundant. How can I get a concise summary of potential
genes to follow?
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| Analysis/Comments |
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The user's initial search results were very large because Entrez Nucleotides draws
its data from a number of sources, including GenBank, which is an archival (and
therefore redundant) database. Therefore, the user is potentially getting many
different records for the same genes. The nucleotides data domain also includes
sequence records from over 125,000 different species, which also contributes to
the large number of hits.
To help the user narrow his/her results, consider limiting the search to the
organism of interest (e.g., human), if applicable, and then to the subset of data
that was drawn from a curated, non-redundant database such as RefSeq.
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| Flow Chart |
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- Entrez CoreNucleotide - Duplicate user's search -- enter:
circadian
- On the Search Results
Page - Limit to human by adding AND human [orgn] to the query box
- Limits - In Only From pulldown menu, select RefSeq and click Go
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