- 14 ao--k----d-lb-efghs------- BirA [KH] COG1654 Biotin operon repressor - 70 aompk---vdrlbcefgh-nuj---w FepC [PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components - 103 aompkz--vd-lbcefgh-nuj---w BtuC [PH] COG0609 ABC-type cobalamin/Fe3+-siderophores transport systems, permease components - 45 ---pkzyq---lbcefgh-nuj--t- LdhA [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases - 47 -ompkzy--drlbcefg-sn-j---- CysH [EH] COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes - 63 aompkzyqvdrlbcefghsnuj---- TrpE [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I - 49 aompkzyqvdrlbcefghsnuj---- PabA [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II - 8 aompkz-------------------- - [EH] COG1685 Archaeal shikimate kinase - 62 aom---yqvdrlbcefghsnujx--- IlvE [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase - 29 a-m-k-yqvdrlbcefghsnuj---- IlvC [EH] COG0059 Ketol-acid reductoisomerase - 72 aompkzyq-d--bcefghsnujxit- PutP [EHR] COG0591 Na+/proline, Na+/panthothenate symporters and related permeases - 97 a-mpkzyqvdrlbcefghsnuj---- IlvB [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] - 14 -----zy-----b-ef-----j---- FUI1 [FH] COG1953 Cytosine/uracil/thiamine/allantoin permeases - 14 -o------v-rlbce-gh-------- MenA [H] COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase - 12 ------y-------efghsn-jx--- UbiG [H] COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase - 55 ------y--dr-bcefghsn-jx--- UbiH [HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - 39 a-mpk-yqv-rlb-efg--n----t- UbiB [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases - 11 -o--------rlbce-gh-------- MenD [H] COG1165 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase - 35 aom--zyqvdrlbcefghsnuj-i-- RibB [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase - 29 a-mpkzyq-d--bcefgh-nujxi-- UbiX [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase - 33 a-mpkzyq-d--bcefgh-nujxi-- UbiD [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases - 12 a-m-------r---efgh-n------ UbiC [H] COG3161 4-Hydroxybenzoate synthetase (chorismate lyase) - 45 aompkzyq-dr-bcefghsnujxi-- UbiA [H] COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases - 39 -o-p--yqvdrlbcefghsnujxitw FolD [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase - 34 -om--zyq-drlbcefghsnujxitw - [H] COG0212 5-formyltetrahydrofolate cyclo-ligase - 33 aompk--qv---bcefghsnujx--- - [H] COG0720 6-pyruvoyl-tetrahydropterin synthase - 30 ------yqvdrlbcefghsnuj-i-- FolK [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase - 49 --mpk-yq-dr-bcefghsnujxi-- BioF [H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes - 46 -o--kz---d-lbcefghsnuj--t- TbpA [H] COG1840 ABC-type iron/thiamine transport systems, periplasmic component - 38 -o--kz---d--bcefgh-nuj--t- ThiP [H] COG1178 ABC-type iron/thiamine transport systems, permease components - 6 --------------e-gh---j---- ThiQ [H] COG3840 ABC-type thiamine transport systems, ATPase components - 15 -o-pk---vdr--cefg----j---- BtuR [H] COG2109 ATP:corrinoid adenosyltransferase - 10 ---------dr-bcefg----j---- CobU [H] COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase - 49 --m---yq-dr-b-efghsnuj-i-- BioA [H] COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase - 4 a-m--z-------------------- - [H] COG1731 Archaeal riboflavin synthase - 20 -------qvdr-bcef--snuj---- PanD [H] COG0853 Aspartate 1-decarboxylase - 19 -o--k--q--r-bcefg-sn-j---- NadB [H] COG0029 Aspartate oxidase - 33 --m---yqv-r-bcefghsnuj-i-- BioB [H] COG0502 Biotin synthase and related enzymes - 38 aom-k-yqvdrlbcefghsnujxit- BirA [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase - 7 a-mp---------c-f---------- CbiD [H] COG1903 Cobalamin biosynthesis protein CbiD - 10 aomp---------c-f-----j---- CbiG [H] COG2073 Cobalamin biosynthesis protein CbiG - 10 aom----------c---h-------- CbiM [H] COG0310 Cobalamin biosynthesis protein CbiM - 16 aompkz---dr-bc-fg----j---- CbiB [H] COG1270 Cobalamin biosynthesis protein CobD/CbiB - 21 -om-------r--c-f-----j---- CobN [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases - 19 aompkz---dr-bcefg----j---- CobS [H] COG0368 Cobalamin-5-phosphate synthase - 17 aomp-----dr-bc-fg----j---- CobQ [H] COG1492 Cobyric acid synthase - 12 aomp-----dr-bc-f-----j---- CobB [H] COG1797 Cobyrinic acid a,c-diamide synthase - 11 a-m------d--b-e-g-s------- PaaK [H] COG1541 Coenzyme F390 synthetase - 10 ------y------cefg-s--jx--- HemF [H] COG0408 Coproporphyrinogen III oxidase - 54 -------qvdrlbcefghsnujxitw HemN [H] COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases - 31 aomp-zyq-dr-bcefghsnujxi-- HemB [H] COG0113 Delta-aminolevulinic acid dehydratase - 16 a-m---y--dr-b-efgh---j---- MenG [H] COG0684 Demethylmenaquinone methyltransferase - 29 -------qvdrlbcefghsnuj-it- Dxs [HI] COG1154 Deoxyxylulose-5-phosphate synthase - 44 aompkzyqvdrlbcefghsnujxitw CoaE [H] COG0237 Dephospho-CoA kinase - 31 --m---yq--r-bcefghsnuj-i-- BioD [H] COG0132 Dethiobiotin synthetase - 39 ------y-vdrlb-efghsn-j-i-w FolA [H] COG0262 Dihydrofolate reductase - 27 ------y--drlbcefghsnuj-i-- FolB [H] COG1539 Dihydroneopterin aldolase - 42 aompkzyqvdrlbcefghsnuj-i-- FolP [H] COG0294 Dihydropteroate synthase and related enzymes - 12 ao--------rlbce-gh-------- MenB [H] COG0447 Dihydroxynaphthoic acid synthase - 16 ------y-----b-efghsnu----- - [H] COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 - 48 aompkzyq-dr-bcefghsnuj---- ThiF [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 - 33 ------yqvdrlbcefghsnuj-itw RibF [H] COG0196 FAD synthase - 35 -o-p--yqvdrlbcefghsnujx-t- FolC [H] COG0285 Folylpolyglutamate synthase - 25 ------yq-drlbcefghs-ujx--- FolE [H] COG0302 GTP cyclohydrolase I - 39 a--p--yqvdrlbcefghsnuj-i-- RibA [H] COG0807 GTP cyclohydrolase II - 9 aompkz-------------------- - [H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase - 6 --------------efgh-------- GshA [H] COG2918 Gamma-glutamylcysteine synthetase - 4 ----------r-------s--j---- GshA [H] COG3572 Gamma-glutamylcysteine synthetase - 74 aompkzyqvdrlbcefghsnujxit- IspA [H] COG0142 Geranylgeranyl pyrophosphate synthase - 35 aomp-z-q-dr-bcefghsnuj-i-- DodA [H] COG0001 Glutamate-1-semialdehyde aminotransferase - 27 aomp-z-q-dr-bcefghsnu--i-- HemA [H] COG0373 Glutamyl-tRNA reductase - 34 aom-kz---d--bcefghsn-j---w RimK [HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) - 13 a---k-y----lb-e--h--u----- ThiM [H] COG2145 Hydroxyethylthiazole kinase, sugar kinase family - 38 aompkzyqvdrlb-efghsnuj--t- ThiD [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase - 16 -o--------rlbcefgh-------- MenF [HQ] COG1169 Isochorismate synthase - 29 -o--kzyqvdr-bcefg-snuj---- PanB [H] COG0413 Ketopantoate hydroxymethyltransferase - 25 ao--kzyq--rlb-efg----j---- ApbA [H] COG1893 Ketopantoate reductase - 26 -o---zyq-dr-bcefghsn-jxi-- LipA [H] COG0320 Lipoate synthase - 41 -o-pkzyqv--lbcefg------i-w LplA [H] COG0095 Lipoate-protein ligase A - 18 ------y--dr--cefghsn-jx--- LipB [H] COG0321 Lipoate-protein ligase B - 21 -------qvd-l--efghsn-j-it- ApbE [H] COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis - 4 aom----------------------- - [H] COG3252 Methenyltetrahydromethanopterin cyclohydrolase - 27 ---p--yqvdr-bcefghsnujxi-- UbiE [H] COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis - 9 -omp------r--c-f---------- ChlD [H] COG1240 Mg-chelatase subunit ChlD - 13 aomp-----dr--c-f---------- ChlI [H] COG1239 Mg-chelatase subunit ChlI - 28 aompkz-q-dr-bcefgh--uj---- MoaC [H] COG0315 Molybdenum cofactor biosynthesis enzyme - 28 aompkz-q-dr-bcefgh--uj---- MoaA [H] COG2896 Molybdenum cofactor biosynthesis enzyme - 42 aompkz-q-dr-bcefgh--uj---- MoeA [H] COG0303 Molybdopterin biosynthesis enzyme - 30 aompkz-q-dr-b-efgh--uj---- MoaB [H] COG0521 Molybdopterin biosynthesis enzymes - 28 aompkz-q-dr-bcefgh--uj---- MoaE [H] COG0314 Molybdopterin converting factor, large subunit - 33 ao-pk--q-dr-bcefgh--uj---- MoaD [H] COG1977 Molybdopterin converting factor, small subunit - 4 ---------------f-h---j---- MopI [H] COG3585 Molybdopterin-binding protein - 19 aompkz-q----b-e-gh--uj---- MobB [H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein - 29 aompkz-q-dr-bcefgh-nuj---- MobA [H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A - 3 a-m----------------------- MtrH [H] COG1962 N5-methyl-tetrahydromethanopterin--coenzyme M methyltransferase - 40 aompkzyqvdrlbcefg-snuj--tw NadE [H] COG0171 NAD synthase - 28 a---kzyqvdrlb-efgh--uj---- SIR2 [H] COG0846 NAD-dependent protein deacetylases, SIR2 family - 21 aompkz---dr-bcefg----j---- CobT [H] COG2038 NaMN:DMB phosphoribosyltransferase - 20 aompkz---drl-ce--h-------- NadR [H] COG1056 Nicotinamide mononucleotide adenylyltransferase - 9 -----------l--ef-h--u----- PnuC [H] COG3201 Nicotinamide mononucleotide transporter - 31 aom-k-yqv-rlbcefghsnuj---- NadC [H] COG0157 Nicotinate-nucleotide pyrophosphorylase - 31 ------yqv-rlbcefg-snuj--tw NadD [H] COG1057 Nicotinic acid mononucleotide adenylyltransferase - 36 ao-pkzyqvdrlbcefghsnuj--tw PncB [H] COG1488 Nicotinic acid phosphoribosyltransferase - 61 ao-p-z--vdrlbcefgh---j---- DgoA [H] COG1441 O-succinylbenzoate synthase and related enzymes - 15 ----------rlb-e-gh---j---- CoaA [H] COG1072 Panthothenate kinase - 22 ------yqvdr-bcefg-snuj---- PanC [H] COG0414 Panthothenate synthetase - 27 -------qvdrlbcefghsnuj--t- CoaD [H] COG0669 Phosphopantetheine adenylyltransferase - 42 aompkzyqvdrlbcefghsnuj--t- Dfp [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase - 5 -----------l--e-gh-------- CitX [HI] COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) - 19 ------y---rlb-efghsnuj---- SerC [HE] COG1932 Phosphoserine aminotransferase - 8 --mp----vd--bc------------ - [HR] COG2045 Phosphosulfolactate phosphohydrolase and related enzymes - 3 --m----q----b------------- BioW [H] COG1424 Pimeloyl-CoA synthetase - 24 ao-p-zyq-dr-bcef--s--jx--- CyoE [H] COG0109 Polyprenyltransferase (cytochrome oxidase assembly factor) - 32 aomp-zyq-dr-bcefghsnujxi-- HemC [H] COG0181 Porphobilinogen deaminase - 12 aomp------r--c-f-----j---- CobH [H] COG2082 Precorrin isomerase - 11 aomp------r--c-f-----j---- CobF [H] COG2243 Precorrin-2 methylase - 11 aomp------r--c-f-----j---- CobJ [H] COG1010 Precorrin-3B methylase - 10 aomp------r--c-f-----j---- CobM [H] COG2875 Precorrin-4 methylase - 10 aomp------r--c-f-----j---- CobL [H] COG2241 Precorrin-6B methylase 1 - 11 aomp------r--c-f-----j---- CobL [H] COG2242 Precorrin-6B methylase 2 - 6 --m-------r--c-f-----j---- CobK [H] COG2099 Precorrin-6x reductase - 7 ----------rl--ef-h-------- NadR [H] COG3172 Predicted ATPase/kinase involved in NAD metabolism - 13 --------vd-lbc----------tw - [H] COG1713 Predicted HD superfamily hydrolase involved in NAD metabolism - 20 aompkzy-vdr-b----h-------- PDX2 [H] COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis - 28 ---p--yq-drlbcefghsnujxi-- HemH [H] COG0276 Protoheme ferro-lyase (ferrochelatase) - 13 ao--k-yq-dr-b--------j-i-- HemY [H] COG1232 Protoporphyrinogen oxidase - 11 -o----yq--r--c-fg-s--j---- - [H] COG2154 Pterin-4a-carbinolamine dehydratase - 12 ------------b-e-gh-n-j---- AbgT [H] COG2978 Putative p-aminobenzoyl-glutamate transporter - 14 -------q-----cefg-snuj---- PdxJ [H] COG0854 Pyridoxal phosphate biosynthesis protein - 17 -------q----bcefghsnuj---- PdxA [H] COG1995 Pyridoxal phosphate biosynthesis protein - 14 ------y--d-l--ef-h---j--t- PdxK [H] COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase - 17 ------y--dr--cefghsn-j---- PdxH [H] COG0259 Pyridoxamine phosphate oxidase - 20 aompkzy-vdr-b----h-------- SNZ1 [H] COG0214 Pyridoxine biosynthesis enzyme - 27 ------yqvdrlbcefghsnuj-i-- RibD [H] COG0117 Pyrimidine deaminase - 36 aom--zyqvdrlbcefghsnuj-i-- RibD [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis - 25 aom-k--qv-r-bcefg-snuj---- NadA [H] COG0379 Quinolinate synthase - 28 -o----yqvdrlbcefghsnuj-i-- RibC [H] COG0307 Riboflavin synthase alpha chain - 34 aom--zyqvdrlbcefghsnuj-i-- RibH [H] COG0054 Riboflavin synthase beta-chain - 20 aompkzyqv-r--c-f--s--j---- SAM1 [H] COG0499 S-adenosylhomocysteine hydrolase - 33 ------yqvdrlbcefghsnuj--tw MetK [H] COG0192 S-adenosylmethionine synthetase - 24 aomp-zyq--r-b-efg-sn-j---- CysG [H] COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) - 24 aompk--q-dr-bcefg-snuj---- ThiS [H] COG2104 Sulfur transfer protein involved in thiamine biosynthesis - 26 aompkz--v--lb-efgh------tw ThiI [H] COG0301 Thiamine biosynthesis ATP pyrophosphatase - 42 aomp-z-qvdr-bce-g---u--i-- ThiH [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes - 24 aom-k--qvdr-bcefg-snuj---- ThiC [H] COG0422 Thiamine biosynthesis protein ThiC - 27 aompkz-q--r-bcefghsnuj---- ThiL [H] COG0611 Thiamine monophosphate kinase - 35 a--pk-yq-drlbcefghsnuj---- ThiE [H] COG0352 Thiamine monophosphate synthase - 10 ------y-vd-lb-------uj--t- THI80 [H] COG1564 Thiamine pyrophosphokinase - 12 a-m-kz-----l--efgh-------- CitG [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase - 5 ------y--------f--s--jx--- CAT5 [H] COG2941 Ubiquinone biosynthesis protein COQ7 - 8 --------------efgh-n------ HemY [H] COG3071 Uncharacterized enzyme of heme biosynthesis - 26 ---p--yq-dr-bcefghsnujxi-- HemE [H] COG0407 Uroporphyrinogen-III decarboxylase - 38 aomp-zyq-dr-bcefg-sn-j---- CysG [H] COG0007 Uroporphyrinogen-III methylase - 34 aomp--yq-dr-bcefghsnu-xi-- HemD [H] COG1587 Uroporphyrinogen-III synthase