CLUSTAL W (1.74) multiple sequence alignment Ta0333 -----------------MKLKFLGGAEEVGRLGVKITDKD-TSVIVDYGVIPEKPP---- TVN0437 -----------------MKLKFLGGAEEVGRLGVKITDRN-TSVIVDYGVIPDKPP---- mlr6574 ---------MKGD--TDPVLRFHGAAHGVTGSCHEIETPH-SRILIDCGLFQGSKSEREL CC0811 ---------------MTISLTFHGAAGCVTGFCARLVTPR-TTVLIDCGMFQGSKTLKAL mll5484 -----------------------------------MRASD-LLHPRPEGLYCPPGD---- CC3644 -----------------------------MSYPDVIKPED-LLCPRPAGLYCPPGD---- PA3614 ----------------MASLTFLGAAQEVTGSCYLLETLDGVKVLLECGMRQGRREADNG AF0532 ----------------MTTINFLGGCREVGRS--AVMVDG---IMIDYGVKPSDPP---- VNG2512G -----------------MDLRFLGGAREVGRS-ALLVGES---LLLDFGTKADTPP---- DRA0069 --MATPHRGILYT--LAMQMQSFGAACTVTGSMHLLTLGG-RHLLVDCGLFQGGDELERR MJ0047 -----------------MEIIFRGAALEVGRSCIEIKTDK-SKILLDCGVKLGKEI---- VC0264 MLRRANHGKVAQNRRNNMEVVHHGGKASVTGSCHELRADG-QALLIDCGLFQGADERP-- MJ0162 ----------------MVLLKFHGGCQQIGMSCVEVETQK-GRVLLDCGMSPDTGE---- APE0181 ----------------MARIRILGSGREVGRAAILVESGG-RGLLLDYGVNFDENDRP-- YLR277c_1 ---------MERTNTTTFKFFSLGGSNEVGRSCHILQYKG-KTVMLDAGIHPAYQG---- PH0724 ------------------------------------------------------------ AF2361 -----------------------------MQIEFYRRKYG--RGCRPHLSLCIEGQ---- sll0514 ---MTFSVPTQGKAFANISFLPYGVGPRDGGICLELHLGP-YRILLDCGLEDLTPL---- APE2295 ------------------------------------------------------------ Ta0333 ---QYPLPPEPV----DAMFITHSHLDHIGAVPVYY-HKG-EPDLYATQMTLNTMKPLLR TVN0437 ---QYPMPPEPV----DAMFITHSHLDHIGAIPVYY-HKG-EPDLYATQMTLNCMKPLLN mlr6574 NYGQFPFPSEAI----DAVILTHAHIDHSGLLAKLV-KQGFSGPIHTTRATIDLCSVMLP CC0811 NYQPFPFDAGQV----DAVLLTHAHIDHSGLLPKLM-LAGFEGPIYATAATRDLGAVMLV mll5484 ---FFIDPVRPV----NRALITHGHSDHA--------RSG-HRSVLATQQTLDIMALRYG CC3644 ---FYIDPVRPV----DRAVVTHGHADHA--------RAG-HGVVAATPETLAIMAVRYG PA3614 NRAPFPFDPASI----DAVVISHAHLDHSGLLPRLA-AEGFKGPIFATEATCELLELMLL AF0532 ---EFPLNGLSP----RAVILSHGHLDHIGVAPNLM-YYD--PEVILTPPSHELSMILLR VNG2512G ---QFPVSTPTP----DAVVASHGHLDHVGTIPALL-SGTHRPPIHWTPPTYELALTLAR DRA0069 NRESFPFEPASL----DAVLLTHAHLDHVGRLPLLV-RLGYRGPVYCTPPTAALAETVLL MJ0047 ---EYPILDNSIR-DVDKVFISHAHLDHSGALPVLF-HRKMDVPVITTELSKKLIKVLLK VC0264 --LAVEFALGHV----DALILTHAHIDHIGRLPWLL-AAGLKQPIYSTAATAELVPLMLE MJ0162 ---IPKVDDKAV----DAVIVSHAHLDHCGAIPFYK-FKK----IYCTHPTADLMFITWR APE0181 ---VFPGDVRPR--DLDGLVLTHSHLDHIGAAPYLY-VSQ-GPKVFGTRVTLHVSRLLLY YLR277c_1 -LASLPFYDEFDLSKVDILLISHFHLDHAASLPYVMQRTNFQGRVFMTHPTKAIYRWLLR PH0724 -MRILTLGLDGSG---EFAFQSHAHTDHFAN----------GRLIFATRPTIFLSHLRNS AF2361 ---HYHVDTSPAD--YGMNLITHAHTDHYGQ------RNMDNSRAVASRESAAILEACTG sll0514 ----LAADPGTV----DLVFCSHAHRDHGLGLWQFH-QQFPHIPILASEVTQRLLPLNWP APE2295 -----------------MKGLSRSVRESL--------L------IIATPYTFRFLEVLGK :: : : : Ta0333 DALKVTN-----------IEGY----P---AMFNEDDINSALANMRP-ARYFESIEVG-- TVN0437 DSLKVTN-----------LEGY----P---AMFNEDDINTALANMKP-ARYFESFDVG-- mlr6574 DAAHVQEMEVEQLNRRNAQRGR----PPVEPIYSLSDAAACMTLFRA-VEYGEWTTVAK- CC0811 DAGGIQENEVESLNRRNLRRGF----PPVEPIYTERDGERVAKQFRK-VKLGEPVRIAE- mll5484 EDFAGTT-----------------------------QA----------ARLGETIALD-- CC3644 EDFAGRR-----------------------------EP----------IPYGESFTRD-- PA3614 DSAHIQEKDAEWENRWRNRIGK----PSIKPLYTQADTERALKLRRP-ISLGSTVAVAR- AF0532 DSMKIMH-------------------P---PPFTKRELRQFESNIRE-VEYEEPITVG-- VNG2512G DTLKLHG---------G-TYHC----P-----FIENDIKRVTEVSRT-HGYGVPFDAA-- DRA0069 DSARLQVEGYRQDLRRARRQGREDEVPP--PLYDEEDVHRTLALLRPQLEFGETVTVA-- MJ0047 DMVKIAET----------ENKK---IP-----YNNHDVKEAIRHTIP-LNYNDKKYYK-- VC0264 DGLKLQL------------GMS----P----KQSERVLTEVRRLLRV-QDYQKWFAVQPK MJ0162 DTLNLTK------------------------AYKEEDIQHAMENIEC-LNYYEERQIT-- APE0181 DMIKLNG-------------AY---LP-----YDERSVEDMLGTAEY-IDYGREYEAG-- YLR277c_1 DFVRVTSIG----------SSSSSMGTKDEGLFSDEDLVDSFDKIET-VDYHSTVDVN-- PH0724 RYYIPVD-------------------------------------------FGKKFYIG-- AF2361 KVFSGVT-----------------------------------------FEVGSRIRLS-- sll0514 DEFVPPF--------------------------------------CRVLPWRSPQEVLP- APE2295 RVPPERR------------------------------------VE---LPYGASLDFD-- Ta0333 ---NMVATPYPAGHIPGSTMWKFEDGIS-------VTVTGDVNTIDTYLING-----AKP TVN0437 ---DFKVTPYPAGHIPGSAMWKFEDGKS-------ITVTGDVNTIDTYLING-----AKP mlr6574 ---GLRTRFWNAGHLLGSASVELEIDLDHQKRPMRILFSGDIGPGHKLLQTDP----EGP CC0811 ---DIVATWWPAGHMLGAASIALDVGPEGQAK--RILFSGDLGPGGSPFLDDP----DAP mll5484 ---SVSVSFHPAGHVLGSAQISVEHQGTR------IVASGDYKRQKDATCAP-----FEP CC3644 ---GVSVTLVPAGHVLGSAQAVVRWKGLT------MVVSGDYKRRRDPTCAR-----FEP PA3614 ---GVRVTFHNAGHILGSSIVEVQFHDQVQPR--RLVFSGDLGNTCSPLMRAP----SPL AF0532 ---DYEVEFFNAGHIPGSASIHMRGDVN-------ILYSGDIRLEETRLLEGA--N-TDY VNG2512G ---GYEVTFYNAGHVPGSAHVLVDDGDTR------LLYTGDFHTTDQRLVSGT----TAR DRA0069 ---GVRVTPQRAGHILGSAYLLLEAPEGR------LLMSGDLGNRESGLQLDF----TPP MJ0047 ---DFSYELFSAGHIPGSASILLNYQNNK-----TILYTGDVKLRDTRLTKGADLS-YTK VC0264 RADSLWVRFQPAGHILGSAYVEIRRPNGE-----VVVFSGDLGPSHTPLLPDP----QSP MJ0162 --ENIKFKFYNAGHILGSASIYLEVDGKK------ILYTGDINEGVSRTLLPAD---TDI APE0181 ---RFAFKTFYSGHIPGSTAVLVEVDGRR------ILYTSDVNVIETKLVGPAR---LEG YLR277c_1 ---GIKFTAFHAGHVLGAAMFQIEIAGLR------VLFTGDYSREVDRHLNSA--E-VPP PH0724 ---DFKAKLYPSGHILGSSGIKIWLDEGT------LYYTGDVKVKKLRTVER-----AKL AF2361 ---DTKIKTYPTYHMHGSAAFYFQDSDI--------LITGDVK---D--------Y-SKL sll0514 ---GLTVELLPAGHLPGAALILLEYHNGD--RLYRVIYTGDYCLSHLQLVDGLALTPLRG APE2295 ---GERVTLVKARHIAGSAQVLVETGHGR------FGYTSDFKMPGTP----------PL : *: *:: . :.* Ta0333 IKTDVLIIESTYAGKNHE--SREDVRKRFRDSVKEVIDSGGKVIMPAFAVG-RTQELIMT TVN0437 IKTDVLIIESTYAGKNHE--SREDVRKRFRESVREVIESGGKVVMPAFAVG-RTQELIMT mlr6574 AGVDYLICESTYGDRERPDVSPEQRRSQLGDIVRRAAEAGGPLIIPSFAVE-RTQELLVD CC0811 AGIDHLILESTYGDRDRTGIDSAARKQQLAEEVRAAHAAGGPLLIPAFAVE-RSQELLID mll5484 IRCDVFITEATFGLPVFR--HPPDTEEIARLLKSAAQFPERSHLVGAYALG-KAQRVMRL CC3644 VPCDVFITEATFGLPVFR--HPDDAGEIRSLLLSVAQFPDRCHLVGAYALG-KAQRVIRL PA3614 SRADVVMLESTYGDRDHR--DSNDTLEELAAILDQAHRDGGNVLIPSFAVG-RTQDLLYY AF0532 PETDILIVESTYFGTEHP--DRKELERAFVESVIDTLDMGGHAIIPAFAVG-RTQEVLMI VNG2512G PEADVVVCESTYSDVTHD--DRDSVEARFAESVKTTLWEGGTVVVPAFAIG-RTQELLLV DRA0069 PAVDAVVIETTYANRTHR--GWVETRAEFAQALRDSVRQNGKILIPSFAIE-RAQTILHT MJ0047 DDIDILIIESTYGNSIHP--DRKAVELSFIEKIKEILFRGGVALIPVFAVD-RAQEILLI VC0264 ERADYLFIETTYGDKQHE--DVQSRGQRLRAMIERSLTDGGAILIPAFSVG-RTQELLFD MJ0162 DEIDVLIIESTYGSPLDIKPARKTLERQLIEEISETIENGGKVIIPVFAIG-RAQEILLI APE0181 AKADVVIVESTYGDSDHP--PRSVSEERFYNAVMDVVSQGGTVLVPAFSVS-RGQEIAMI YLR277c_1 LSSNVLIVESTFGTATHE--PRLNRERKLTQLIHSTVMRGGRVLLPVFALG-RAQEIMLI PH0724 PKADFLIIESTFGLPRFTFPDPRESEKVIIGIVEDLIDRGKVPTFMANPYG-KAQEIIKI AF2361 PKCKILVTEATYGHPSHI------FEEEVEKLLKVAS--SNKAVFGAYPIG-KAQRVAEI sll0514 LKPDVLILEGHYGNRRLP--HRRQQEKQFIQAIETVLAKGRNILLPVPPLG-LAQEILKL APE2295 QDLDILVVDATYGSPRLQ--RRWSEWDAIAALIEIIDRFVGEGPVWIYGYNGKLQEVMAQ . .. : : . * : Ta0333 IADMG-----------YDVAVDG-MGNDISTIYL-NTPGFLRSKKEFLRALSKV------ TVN0437 IADMG-----------YDVSVDG-MGNDISSIYL-NTPGFLKSKRDFLRALGKV------ mlr6574 LYLLMQAGEVLT----APVFVDSPLATRASAIF--ERHANDIEQGDVLRQALNS------ CC0811 LLDLMDQGEVPR----GDIFLDSPLAIEATKVFQ-ERGWNPQTQTNPFEALRPS------ mll5484 LRDAG---------------YDR-------PLY---IHGALARLSEYYQSQG-------- CC3644 LREAG---------------WDK-------TIY---VHGALERLNALYEAHG-------- PA3614 LGRFYQEGRLPQ----QAVFLDSPMAARANGIYLRHSNEFDDRDREYIRGTGTTRLEEWL AF0532 LERYG-----------ITPYVDG-MGKEVAQVIQ-RHPDFIRSPKELKRAVRNA------ VNG2512G CDAHD-----------IPCYVDG-MGKRVTEMLL-RYPGFVRDGDALRRAKSHA------ DRA0069 LKEMMDSGEVPR----IPVFLDSPMAARATNEYFEYGDELIPPVREALRNGEDP---FRP MJ0047 LNDYN-----ID----APIYLDG-MAVEVTKLML-NYKHMLNESSQLEKALKNV------ VC0264 IEQLIFSQQIDAN---LPIILDSPMAQRVTRSYRRFKQLWGREAKARLQMHRHP--LAFE MJ0162 INNYIRSGKLRD----VPIYTDG-SLIHATAVYMSYINWLNPKIKNMVENRINP-----F APE0181 LAERG------FE---YPVWLDG-MIRQVAEIYA-ANPRFILNPGLLMKVMSEF------ YLR277c_1 LDEYWSQHADELGGGQVPIFYASNLAKKCMSVFQTYVNMMNDDIRKKFRDSQTN--PFIF PH0724 LNVHG-----------YSVSVDR-EIAKVSKFYMKFGVRLKFEKEGEVKVSSSK-----G AF2361 LSKDG-----------FGFSAEEKIARICSAVGLKPSDGPLIASPRNLPLYGGG----YI sll0514 LRTHHQFTG------RQVNLWAGESVARGCDAYQGIIDHLPDNVRNFAQHQPLFWDDKVY APE2295 LRLRG----------VDYPFVADEKTYRLSLIASEFYGVDLGEVEIYTGGPIDY------ Ta0333 RIIKGRNMR--ENAIRSD---------IIISTSGMLDGGPVLGYIQKLL-------EDEK TVN0437 REVKGRRMR--ENAINSD---------IIISTSGMLDGGPVLGYIQKLM-------EDEK mlr6574 RELRFTETV--EQSKAINRLSGF---FVVIAASGMCDAGRIRHHLKANL-------WRRN CC0811 QHLRFLDSP--AESDGLDRLKGW---HVILAASGMCDAGRVRKHLQRLL-------WRRE mll5484 IDLGVLEPA--TVEGGKD------------DFTGAIVVGPPSAFADR---------WARR CC3644 VDLGPLAPA--TASGPKD------------AFAGQIVIAPPSAIADR---------WSRR PA3614 PVLRVTRSA--DESMAINRIKSG---AVIIAGSGMCTGGRIVHHFKHNL-------WRPE AF0532 IPVEWRQRE--RVLEEPS---------AVVTTAGMLNGGPAMFYISRLY-------NDEK VNG2512G RFVTGRDGQ--RKRIADQQ-------AAIVTTSGMLSGGPAMTYIPEIR-------SNPV DRA0069 STLHTVTTS--AESQRLNRYDGP---AIIMAGNGMMTGGRIQHHLKHHL-------WKPS MJ0047 KIIEKSEDR--IKAIENLSKNG----GIVVTTAGMLDGGPILYYLKLFM-------HNPK VC0264 QCITVEDHR--THERLVNRLASTGEAAIVVAASGMCQGGRIMDYLKALL-------PDKR MJ0162 GEIKKADES--LVFNKEP--------CIIVSTSGMVQGGPVLKYLKL-L-------KDPK APE0181 RIVSGWQDR--RRAFKKP--------GVIIASAGMLKGGPSLYYARKMA-------TNKK YLR277c_1 KNISYLRNL--EDFQDFGP-------SVMLASPGMLQSGLSRDLLERWC-------PEDK PH0724 ISVSGFGRI--KLSNHAD----------FWELLEIVERVNPEKVFTVYG-------HAEA AF2361 LTAHKFYRW--PRITLSD----------HLDYRGILEMIDHCEPEEVLFY------HGKP sll0514 PHLRPLTDDQGELSLSAPSIVITTTWPAFWPSPAALPGLWTVFMPQLLTLPSCLVNFAWQ APE2295 SAVVFLHMTRLNSIRRFPG--------VHVRLTGWEMRAPAAWSGDRMIN---VSFSDHA Ta0333 SAIFVTGYQVEGTNGRSLLETGT-LTIAGVT-----VKPKMR---VEFFDMS-AHAGHDE TVN0437 SAIFVTGYQVEGTNGRSLLENGT-ITVAGVT-----MKPKMR---VEFFDMS-AHAGHDE mlr6574 ATVMMAGYQAQGSLGRILLDGAQRVRIQGEE-----VEVKAR---ISLFDLYSGHADAGE CC0811 ATVLLCGYQATGTLGRLLADGRNRVTIRGDE-----ISVRAR---IRQLDAYSGHADAAG mll5484 FPDPISCFASGWMRIRQRAKQGG----------------------VELPLIISDHADWDE CC3644 FPDPVDCFASGWMRVRARARQRG----------------------VELPLILSDHADWDE PA3614 CHVVFPGFQARGTLGRNIVDGASAVRVFHQR-----IAVKAQ---IHTLGGFSAHAGQSQ AF0532 SKILLTGYQVEGTNGDMALKTGM-LNLGTRV-----VKLKMG---VEQYDFS-AHADDRQ VNG2512G NKIAMTGYQVAGTPGRSLIDSGR-AEIDGRV-----LPVSAQ---VEQYDFS-AHADHAG DRA0069 TSLIIVSYQSPSSLGGRIVAGQGTVHLMGED-----VAVRAQ---VHTIGGFSAHADQDD MJ0047 NALLLTGYQVRDSNGRHLIETGK-IFIGKDE-----IKPNLE---VCMYNFS-CHAGMDE VC0264 TDLILAGFQAEGTLGRSIQSGQPSVWIEGTE-----VEVNAH---IHTMSGYSAHADKAD MJ0162 NKLILTGYQAEGTLGRELEEGAKEIQPFKNK-----IPIRGK---VVKIEFS-AHGDYNS APE0181 NGIFMVSYQAPGTPGRMILEEGV---FGEER-----IPVLAR---VEWFDFS-SHIDQSG YLR277c_1 NLVLITGYSIEGTMAKFIMLEPDTIPSINNPE--ITIPRRCQ---VEEISFA-AHVDFQE PH0724 FAKILNGLGYEAKSIRRNQKLEVW------------------------------------ AF2361 SKRLLEHLKNEGIVCRTLNDLPVMK----------------------------------- sll0514 DLEEFPKYELEDYLLADHSDGRNTTQLIHNLRPQHLVFVHGQPSDIEDLTSLEELQSRYQ APE2295 TFREIIDYVREARPKRVIVDAYRGSDAWFTA--------K----YIEKVLGIRSEAQP-- . Ta0333 LVN--------------FIKAIDPKK---IVLCHG---------------DHRENLLP-- TVN0437 LVS--------------FIKAINPEK---VVLMHG---------------DHREELLP-- mlr6574 LVA--------------WVKARTPVKQQ-VFLTHGEEAGL---------SGLRGRLAG-- CC0811 LVR--------------WAKDRLPITGS-VFLAHGEPDAT---------EGLRRRLVEA- mll5484 LTA--------------TIKETGAEE---IWVTHGREE-----------ALVRWCELEG- CC3644 LTG--------------TLDELRPGE---VWITHGREE-----------ALERWCQLEG- PA3614 LLD--------------WVGHFAHRP-A-LYLIHGEREKM---------EALQSAIRE-- AF0532 LKE--------------YVKRVVDRGAEVVFTIHGEET-----------EAFAEWIKD-- VNG2512G LRA--------------FLDDYRDAT---VLVNHGDDC-----------AAFADALRD-- DRA0069 LLA--------------FLDTAGKPH---VWLVHGEVNVM---------DAFLPLLAE-- MJ0047 LHE--------------IIKKVNPEL---LIIQHGEEVQA---------TILRNWALE-- VC0264 LLR--------------FITGIPEKPKQ-VHLIHGEAPAK---------QAFAAELTQ-- MJ0162 LVR--------------YIKKIPKPEK--AIVMHGERYQS---------LSFAMTIWK-- APE0181 IIK--------------LLRSVNGVEK--VVLVHGDPKAQ---------EALKTRIRE-- YLR277c_1 NLE--------------FIEKISAPN---IILVHGEANPM---------GRLKSALLS-- PH0724 ------------------------------------------------------------ AF2361 ------------------------------------------------------------ sll0514 LHSPAAGNAVALPIGDRFVQPTPPPPQIYEGEIHELEPNKQIHHLGEVVIHLDGQILENS APE2295 ------------------------------------------------------------ Ta0333 --DLEGYDVLLPYNGKEYEI---------------------------------------- TVN0437 --DLEGYDVLLPYNGKEYEI---------------------------------------- mlr6574 --LIPDDKVIIPRLDDAFQLT-PGRCLPVEVNEPRRLRPEKIARLDWHNDLSRLLMDVNE CC0811 --DFPAERLVIPALDEGFALDGVGAAQPIGEARPR-LPAAAPGKLDWHNQRVAFQLALGQ mll5484 --IAARPLHLVGYEDE-GD----------------------------------------- CC3644 --IPARALRLVGYEDEEGE----------------------------------------- PA3614 ---RLDWDAEIPEPGERIEI---------------------------------------- AF0532 ---NIGVEAYAPKNGEIYVI---------------------------------------- VNG2512G ----AGFTARAPERDDTCPV---------------------------------------- DRA0069 ---RGLKGDIVPDRSP-VDLLGAGFSS---GRPPGLVVPPQNGKGQGEGGE--------- MJ0047 ----HGFDAITPKLGEKIRI---------------------------------------- VC0264 ----LGYSVL-------------------------------------------------- MJ0162 ---TLKIPTFVPVRGTILPI---------------------------------------- APE0181 --ELGIREVETPGNMDVLEV---------------------------------------- YLR277c_1 -----NFASLKGTDN--------------------------------------------- PH0724 ------------------------------------------------------------ AF2361 ------------------------------------------------------------ sll0514 RWGKFGETGIVQARWQGEELVLRGISQRELLKQNQSSKRPVDFDCCANCRHFQHYHCRNP APE2295 ------------------------------------------------------------ Ta0333 --------------------------- TVN0437 --------------------------- mlr6574 AVSAAADERGRAAVIRRMRRALEDKDA CC0811 ALAAAPDDRAREALLKALSATLEGRP- mll5484 --------------------------- CC3644 --------------------------- PA3614 --------------------------- AF0532 --------------------------- VNG2512G --------------------------- DRA0069 --------------------------- MJ0047 --------------------------- VC0264 --------------------------- MJ0162 --------------------------- APE0181 --------------------------- YLR277c_1 --------------------------- PH0724 --------------------------- AF2361 --------------------------- sll0514 VSPLMGLEVRADGHCPVFESVASS--- APE2295 ---------------------------