CLUSTAL W (1.74) multiple sequence alignment leuS ------------------------------------------------------------ ZleuS ------------------------------------------------------------ VC0956 ----------------------------MAAGLAIVVTPCFLYSMPNRKTSFLLNSQIPR HI0921 ------------------------------------------------------------ PM1214 ------------------------------------------------------------ NMB1897 ------------------------------------------------------------ NMA0559 ------------------------------------------------------------ PA3987 ------------------------------------------------------------ XF2176 -----------------------------------------------------MLFHASP BU444 ------------------------------------------------------------ jhp1452 ------------------------------------------------------------ HP1547 ------------------------------------------------------------ Cj1091c ------------------------------------------------------------ mll4077 ------------------------------------------------------------ CC3749 ------------------------------------------------------------ RP421 ------------------------------------------------------------ VNG2223G ------------------------------------------------------------ aq_351 ------------------------------------------------------------ sll1074 ------------------------------------------------------------ TM0168 ------------------------------------------------------------ DR2174 MRKVPGCVCAGAIFLLMVERPAPAKATATALVPSPISEAEPSPINLQRSHLMTQEATKPN BS_leuS ------------------------------------------------------------ BH3281 ------------------------------------------------------------ L0352 ------------------------------------------------------------ SPy0173 ------------------------------------------------------------ TP0586 ------------------------------------------------------------ BB0251 ------------------------------------------------------------ MG266 ------------------------------------------------------------ MPN384 ------------------------------------------------------------ UU371 ------------------------------------------------------------ CT209 ------------------------------------------------------------ CPn0153 ------------------------------------------------------------ Rv0041 --------------------------------------------MTESPTAGPGGVPRAD ML0032 --------------------------------------------MTELPTTVPGYNSAVA PH0965 ------------------------------------------------------------ PAB1782 ------------------------------------------------------------ MJ0633 ------------------------------------------------------------ AF2421 ------------------------------------------------------------ MTH1508 ------------------------------------------------------------ Ta0777 ------------------------------------------------------MDDRGR TVN0761 ------------------------------------------------------MDYS-- APE1015 ------------------------------------------------------------ YLR382c -------------------------------------------------------MLSRP aq_1770 ------------------------------------------------------------ YPL160w ------------------------------------------------------------ leuS ----MQEQYRPE-----EIESKVQLHWDEKRTFEV------------TEDESKEK---YY ZleuS ----MQEQYRPE-----EIESKVQLHWDEKRTFEV------------TEDESKEK---YY VC0956 WMSSMQEQYNPQ-----DIEHKVQQHWDNNKTFVV------------SEDPNKEK---FY HI0921 ----MQEQYRPD-----MIEPKVQQYWAENKVFKA------------IKDESKEK---YY PM1214 ----MQEQYRPD-----LIEAEVQQYWAENKTFKA------------IKDTNKPK---YY NMB1897 ----MQEQYRPA-----AIEPAAQKKWDDARIFNV------------SEDASKPK---YY NMA0559 ----MQEQYQPA-----AIEPAAQKKWDDARIFNV------------SEDASKPK---YY PA3987 ----MHEQYQPL-----EIETQAQNYWKEHQSFLV------------RELPDKEK---FY XF2176 LMPTEANTYDPQ-----RIESTAQHYWDSTHAFEV------------NEHSNKPK---YY BU444 ----MEKEYSPK-----KIENYVQEFWKKNKTFEV------------KEDPKKEK---YY jhp1452 ------MDFIN-------IEKKWQEFWWKNKSFEP------------KDDFNLPK---KY HP1547 ------MDFIN-------IEKKWQEFWWKNKSFEP------------KDDFNLPK---KY Cj1091c ------MAYEAS-----LIEKKWQKIWDENEYFEP------------KDDLNLPK---KY mll4077 ---MATERYNPR-----ASEPKWQKAWAEKKLFEA------------RNDDPKPK---YY CC3749 -----MARYNPK-----DTEPKWREAWAKADVFKTG-----------EINDGRPK---YY RP421 ----------MH-----KIEKKWQKIWQEEKAFQV------------SNESSKPK---YY VNG2223G --MGEQATYDHH-----AIEQHWQREWDDADVFRV-------------PDDADDP---EY aq_351 ----MMKEFNPR-----EIEKKWQKRWEEAGVFKA-------------QEGKPNK---FY sll1074 ----MASPYNAG-----EIEQKWQQRWAEWGLDKT------------PIASDLPK---FY TM0168 -----MKEYRPQ-----EIEKKWQEVWEEKKVFYT------------PQRSEKPK---YY DR2174 IQEPRAERYNPH-----AIEQKWQGQWQESGLYKF------------DENAPGEK---FY BS_leuS ------MSFQHK-----EIEKKWQTYWLENKTFAT------------LDNNEKQ---KFY BH3281 ------MSFSHR-----EIESKWQKYWEENKTFKT------------EEDETRE---KFY L0352 ------MEYNHQ-----EIEAKWQKYWADNKTFRT------------GTDKNKP---KFY SPy0173 -----MTFYDHT-----AIEPKWQAFWADNHTFKT------------GTDASKP---KFY TP0586 ------MGYPFR-----ALEKKWQAYWRDKRVFCV------------SEDERFPPERRAY BB0251 -----MSKYEFI-----KIEKKWQEFWDNNKTYKV------------EEDPSIPKEKRLY MG266 -------MYNHN-----LIEEKWLKKWKNKDVNRF------------ESDSNKKK---YY MPN384 -------MYNHN-----LLEEKWLQLWKTKQVNRF------------FDDKTKPK---YY UU371 -------MYNHN-----KIEKKWQKYWLDNKTFKF------------VDNPNNPKK--FY CT209 ------MRYDPG-----LIEEKWQKFWENEQVFKA------------EEDETKTK---YY CPn0153 ------MRYDPN-----LIEKKWQQFWKEHRSFQA------------NEDEDKVK---YY Rv0041 DADSDVPRYRYTAELAARLERTWQENWARLGTFNVPNPVGSLA----PPDGAAVPDDKLF ML0032 QTDSDAMRYRYTAELAGRIESTWQDNWARLQTFNVPNPVGSLA----PPDGSVVPADKLF PH0965 ------MAELNFKA----IEEKWQKRWLEAKIFEP------------NIRDKPKE-KKFY PAB1782 ------MPELNFRA----IEEKWQKRWLEAKVFEP------------NIKDKPKE-KKFY MJ0633 -----MMVMIDFKE----IEKKWQKRWEEAKIFEA------------NPDDR----EKFF AF2421 --------MSDFRI----IEEKWQKAWEKDRIFES------------DPNEK----EKFF MTH1508 ------------MD----IERKWRDRWRDAGIFQA------------DPDDR----EKIF Ta0777 RCC--THSGVIALD----IEAKWQNAWDRDGIFVP------------KMDGR----KKFM TVN0761 RCCGSTNSRVIYMN----IDEKWQNAWERDHVFEP------------KIDER----KKFM APE1015 ------MERLKA------VEEKWQERWREARLFEA------------DPQPGRRK---FF YLR382c SSRFLSTKRGPGP--AVKKLIAIGEKWKQKTTRGLP-----------KQDTLNSG--SKY aq_1770 ------------------------------------------------------------ YPL160w MSSGLVLENTARRDALIAIEKKYQKIWAEEHQFEIDAPSIEDEPITMDSEELHRTYPKFM leuS CLSMLPYPSG-RLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNN- ZleuS CLSMLPYPSG-RLHMGHVRNYTIGDVIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNN- VC0956 CLSMFPYPSG-RLHMGHVRNYTIGDVVSRFQRLQGKNVLQPIGWDAFGLPAENAAVKNN- HI0921 CLSMFPYPSG-RLHMGHVRNYTIGDVISRYQRMLGKNVLQPFGWDAFGLPAEGAAIKNK- PM1214 CLSMFPYPSG-RLHMGHVRNYTIGDVVSRYQRMNGKNVLQPMGWDAFGLPAEGAAIKNK- NMB1897 CLSMFPYPSG-KLHMGHVRNYTIGDVLSRFKLLNGFNVMQPMGWDAFGMPAENAAMKNN- NMA0559 CLSMFPYPSG-KLHMGHVRNYTIGDVLSRFKLLNGFNVMQPMGWDAFGMPAENAAMKNN- PA3987 CLSMFPYPSG-KLHMGHVRNYTIGDVISRYHRMQGRNVLQPMGWDAFGMPAENAAMKNN- XF2176 CLSMLPYPSG-ALHMGHVRNYTIGDVISRYKRMTGHNVLQPMGWDAFGLPAENAAIKNK- BU444 CLPMLPYPSG-KLHMGHVRNYTISDVISRYQRMLGKNVLQPMGWDAFGLPAEEAAIRNN- jhp1452 ILSMLPYPSG-EIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHG- HP1547 ILSMLPYPSG-EIHMGHVRNYTIGDALARYYRLHHYNVLHPMGFDSFGMPAENAAIKHG- Cj1091c ILSMFPYPSG-RIHMGHVRNYTIGDALARYYRKIGFNVLHPIGFDSFGMPAENAAIKHK- mll4077 VLEMFPYPSG-RIHIGHTRNYTMGDVVARYKRAKGFNVLHPMGWDAFGMPAENAAMQNK- CC3749 VLEMFPYPSG-RIHMGHVRNYAMGDVVARYKRAQGFNVLHPMGWDAFGMPAENAAMERG- RP421 VLEMLPYPSG-KIHIGHVRNYSIGDVIARFMTMQGFNVLHPMGWDAFGLPAENAAIKNN- VNG2223G VLAMFPYTSG-QLHMGHVRNYAITDAFARYRRMDGEDVLHPMGWDSFGLPAENAANERD- aq_351 VLEMFPYPSG-RIHMGHVRNYTIGDAIARYLKMRGKNILHPMGWDAFGLPAENAAIKHG- sll1074 ALSMFPYPSG-NLHMGHVRNYTITDVIARLKRMQGYQVLHPMGWDAFGLPAENAAIERG- TM0168 ALVMFPYPSG-TLHVGHVKNYVIGDIVARYKRMRGYNVLHPFGYDAFGLPAENAAIEKG- DR2174 ALTMFPYPSG-NLHIGHWYANVAPDARARWLRMRGYNVLFPMAFDAFGLPAENAAIKNN- BS_leuS ALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTG- BH3281 ALDMFPYPSGAGLHVGHPEGYTATDILSRMKRMQGYNVLHPMGWDAFGLPAEQYAIDTG- L0352 ALDMFPYPSGAGLHVGHPEGYTATDILSRYKRAQGFNVLHPMGWDAFGLPAEQYAMDTG- SPy0173 ALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNILHPMGWDAFGLPAEQYAMDTG- TP0586 VLDMFPYPSAQGLHVGHPEGYTATDIYCRYLRMGGYNVLHPMGFDAFGLPAENFALKTG- BB0251 ILDMFPYPSANGLHVGHPEGYTATDIFGRYKLLNGFHVLHPIGFDSFGLPAENYAIQTG- MG266 VLDMFPYPSAAGLHLGHVRAYTITDVISRYYKAKGFNVIHPIGFDAFGLPAEQYAINSN- MPN384 ILDMFPYPSAAGLHLGHVRAYTITDVLSRYHKAKGFNVIHPIGFDAFGLPAEQYAIASN- UU371 VLDMFPYPSGKGLHVGHPKGYTATDVISRFKRLNGYDVLHPIGWDAFGLPAEQYALETN- CT209 VLDMFPYPSGAGLHVGHLIGYTATDIVARYKRAQGFSVLHPMGWDSFGLPAEQYAIRTG- CPn0153 VLDMFPYPSGAGLHVGHLIGYTATDIVARYKRARGFSVLHPMGWDSFGLPAEQYAIRTG- Rv0041 VQDMFPYPSGEGLHVGHPLGYIATDVYARYFRMVGRNVLHALGFDAFGLPAEQYAVQTG- ML0032 VQDMFPYPSGDGLHVGHPLGYIATDVYARYFRMTGHNVLHAMGFDAFGLPAEQYAMQTG- PH0965 ITVAFPYLSG-HLHVGHARTYTIPDVIARFKRMQGYNVLFPMAWHITGSPIVGIAERIKN PAB1782 ITVAFPYLSG-HLHVGHARTYTIPDVIARFKRMQGYNVLFPMGWHITGSPIVGIAERIKN MJ0633 ITAAFPYLNG-VLHAGHLRTFTIPEVVARFQRMKNKNVLWTFGYHVTGTPILGLAELIKN AF2421 LTIPYPYLNG-NLHAGHTRTFTIGDAFARYMRMKGYNVLFPLGFHVTGTPIIGLAELIAK MTH1508 LTVAYPYPSG-AMHIGHGRTYTVPDVYARFKRMQGYNVLFPMAWHVTGAPVIGIARRIQR Ta0777 ITVPWPYTNG-SLHVGHGRTYTLGDIIARYKRSRNYNVLFPMGFHQSGTPILAFSERIRA TVN0761 ITVPWPYTNG-SLHVGHGRTYTLGDIIARYKRSRNYNVLFPMGFHQSGTPILAFSERIRA APE1015 ITFPYPYVNA-YPHLGSAFTILRVDIMARYKRMRGYNVLFPQGWHATGGPIVSSALRVRE YLR382c ILCQFPYPSG-ALHIGHLRVYVISDSLNRFYKQKGYNVIHPMGWDAFGLPAENAAIERS- aq_1770 ------------------------------------------------------------ YPL160w SSMAYPYMNG-VMHAGHCFTLSKVEFSIGFERMNGKRALFPLGFHCTGMPILACADKLKR leuS ------------------------------------------------------------ ZleuS ------------------------------------------------------------ VC0956 ------------------------------------------------------------ HI0921 ------------------------------------------------------------ PM1214 ------------------------------------------------------------ NMB1897 ------------------------------------------------------------ NMA0559 ------------------------------------------------------------ PA3987 ------------------------------------------------------------ XF2176 ------------------------------------------------------------ BU444 ------------------------------------------------------------ jhp1452 ------------------------------------------------------------ HP1547 ------------------------------------------------------------ Cj1091c ------------------------------------------------------------ mll4077 ------------------------------------------------------------ CC3749 ------------------------------------------------------------ RP421 ------------------------------------------------------------ VNG2223G ------------------------------------------------------------ aq_351 ------------------------------------------------------------ sll1074 ------------------------------------------------------------ TM0168 ------------------------------------------------------------ DR2174 ------------------------------------------------------------ BS_leuS ------------------------------------------------------------ BH3281 ------------------------------------------------------------ L0352 ------------------------------------------------------------ SPy0173 ------------------------------------------------------------ TP0586 ------------------------------------------------------------ BB0251 ------------------------------------------------------------ MG266 ------------------------------------------------------------ MPN384 ------------------------------------------------------------ UU371 ------------------------------------------------------------ CT209 ------------------------------------------------------------ CPn0153 ------------------------------------------------------------ Rv0041 ------------------------------------------------------------ ML0032 ------------------------------------------------------------ PH0965 RDPKTIWIYRDVYKVPEEI----------------------------------------- PAB1782 RDPHTIWIYRDVYKVPEEI----------------------------------------- MJ0633 RDEKTIWAYTELHGIPKEE----------------------------------------- AF2421 RDERTIEVYTKYHDVPLED----------------------------------------- MTH1508 KDPWTLKIYREVHRVPEDE----------------------------------------- Ta0777 GDRSTIDLYTSYLKEYGEKDIDA------------------------------------- TVN0761 GDASTIALYRSYLSEYGEKDIDG------------------------------------- APE1015 GDPRIIKTLRDMGIPEED------------------------------------------ YLR382c ------------------------------------------------------------ aq_1770 ------------------------------------------------------------ YPL160w EAELFGKNFDNVPAEEEEIKEETPAEKDHEDVTKFKAKKSKAAAKKGRGKYQFEIMLQLG leuS ---------TAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPE--YYRWEQKFFTEL ZleuS ---------TAPAPWTYDNIAYMKNQLKMLGFGYDWSRELATCTPE--YYRWEQKFFTEL VC0956 ---------TAPAPWTYENIEYMKNQLKLLGFGYDWNREFATCRPE--YYRWEQEFFTKL HI0921 ---------TAPAKWTYENIAYMKKQLQLLGFGFDWDREIATCKPE--YYKWEQWFFTEL PM1214 ---------TAPAKWTYENIDYMKNQLKILGFGFDWDREVTTCKPD--YYKWEQWFFTEL NMB1897 ---------VAPAAWTYDNIEYMKTQLKSLGFAIDWARETATCKPE--YYRWEQWLFTKL NMA0559 ---------VAPAAWTYDNIEYMKTQLKSLGFAIDWARETATCKPE--YYRWEQWLFTKL PA3987 ---------VAPAAWTYDNIAYMKSQLDSLGLAIDWSREVTTCKPD--YYRWEQWLFTRL XF2176 ---------VAPAQWTYKNIERMRTQLKSLGYAIDWSREFATCQPD--YYVHEQHMFTRL BU444 ---------TDPFSWTQKNIKYMKKQLQSLGFSYDWSREITTCHPE--YYHWEQWFFTKL jhp1452 ---------IHPKTWTYENIEAMQKEFEALGFSFSKNREFATSDPD--YTKFEQQFFIDL HP1547 ---------IHPKTWTYENIENMQKEFEALGFSFSKNREFATSDPD--YTKFEQRFFIDL Cj1091c ---------IHPKSWTYENIAYMKKELFSLGFSFSKKRMLATSDPL--YTKFEQEFFIKM mll4077 ---------VHPKEWTYQNIATMREQLKVMGLSLDWAREFATCDVD--YYHRQQMLFLDF CC3749 ---------VHPKGWTYDNIAAMREQLKSLGISVDWSREFATCDPE--YYGKQQAWFLRL RP421 ---------SRPQDWTYSNIEYMKKQLQSMGFAYDWTREINSCDPE--YYKHEQKFFLEL VNG2223G ---------TNPREWTERCIDQMRDQFEALGFGYDWEREITTCDPD--YYKWNQWLFTEF aq_351 ---------IHPAKWTYENIDYMKKQLKILGFSYDWDREIATCDPE--YYKWNQWIFLKM sll1074 ---------IPPKQWTEKNIAQMRAQLQQLGLSIDWEREVATCAPD--YYRWTQWLFLEF TM0168 ---------IHPEEWTRKNIATIRQQVKKLGISYDWSREIATCDEE--YYKWTQWIFLQL DR2174 ---------TNPATWTYANIERMTGQFSRMGTMIDWSRKFATCDPE--YYRWNQWFFIEF BS_leuS ---------NDPAVFTKQNIDNFRRQIQALGFSYDWDREINTTDPE--YYKWTQWIFLKL BH3281 ---------NSPAEFTEKNINTFRRQIKSLGFSYDWDREVNTTDPD--YYKWTQWIFIQL L0352 ---------NDPAEFTAENIANFKRQINSLGFSYDWEREVNTTDPN--FYKWTQWIFTKL SPy0173 ---------NDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPN--YYKWTQWIFTKL TP0586 ---------THPRVSTSANCDTFRRQIQSFGFSYDWEREISTADPE--YYRWTQWLFLKL BB0251 ---------THPQKSTEENINKFKKQIKALGFAYDWDREIRTHEEN--YYKWTQWIFLQL MG266 ---------QNPGSWTDQNINNFINQLTSFGFDYDYHLSLKTTDPR--YYKYTQWIFSEL MPN384 ---------KHPGDWTDKNITNFIEQLTAFGFDYDYQLSLKTTDPR--YYQYTQWIFGQL UU371 ---------NHPHTFTQQNIKIFRKQLQMIGFDFDYDKEVDTTDPQ--FYQWTQWIFVQL CT209 ---------THPRETTEKNIANFKKQLTAMGFSYDESREFATSDPE--YYKWTQKLFLIL CPn0153 ---------THPKVTTQKNIANFKKQLSAMGFSYDEGREFATSDPD--YYHWTQKLFLFL Rv0041 ---------THPRTRTEANVVNFRRQLGRLGFGHDSRRSFSTTDVD--FYRWTQWIFLQI ML0032 ---------THPRILTEANVVNFRHQLGRLGLGHDSRRTFSTTDVE--FYKWTQWIFLQI PH0965 -----LWTFEDPINIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFWKL PAB1782 -----LWTFEDPVNIVKYFMKAAKETFIRAGFSVDWSREFYTTSLFPPFSKFIEWQFLKL MJ0633 -----LLELTTPEKIVEYFSKKAEEAFKRMGFSLDWRRNFKTDDKV--FNKFIEWQFHKL AF2421 -----LLQLTTPEKIVEYFSREALQALKSIGYSIDWRRVFTTTDEE--YQRFIEWQYWKL MTH1508 -----LERFSDPEYIVEYFSREYRSVMEDMGYSIDWRREFKTTDPT--YSRFIQWQIRKL Ta0777 ----LIESFKDPKNIADYFSNAIINDFKHLGYSIDWTRRFTSADEF--YQKFVQWQFRRL TVN0761 ----WLEKFKDPRNIADYFSNAIINDFKHLGYSIDWTRKFTSADEF--YQNVVKWQFHKL APE1015 -----IPRFRDPRYWVEFFTKAWRRDLERYGMSIDWRREFYTTSLNPAYSRFIEWQYLKL YLR382c ---------INPAIWTRDNIAKMKQQMQSMLANFDWDREITTCDPE--YYKFTQWIFLKL aq_1770 ------------------------------------------------------------ YPL160w IPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDANPYYDAFIRWQMNKL leuS Y---------------------KKG--------------------------LVYKKTSAV ZleuS Y---------------------KKG--------------------------LVYKKTSAV VC0956 F---------------------AKG--------------------------LVYKKTSSV HI0921 Y---------------------KKG--------------------------LVYKKTSTV PM1214 Y---------------------KKG--------------------------LVYKKTSTV NMB1897 F---------------------EKG--------------------------IVYRKNGTV NMA0559 F---------------------EKG--------------------------IVYRKNGTV PA3987 F---------------------EKG--------------------------VIYRKNGTV XF2176 M---------------------RKG--------------------------LAYRRNALV BU444 Y---------------------EKK--------------------------LVYKKNSLV jhp1452 W---------------------EKG--------------------------LIYRKKAML HP1547 W---------------------EKG--------------------------LIYRKKAML Cj1091c F---------------------EKG--------------------------LIYTKEANV mll4077 V---------------------EKG--------------------------LVTRKSSKV CC3749 L---------------------KRG--------------------------LVYRKEASV RP421 Y---------------------DRN--------------------------LVYQKESLV VNG2223G R---------------------DAG--------------------------LVDRRAATV aq_351 L---------------------ERG--------------------------IAYRKTAKV sll1074 F---------------------QAG--------------------------LAYQKEATV TM0168 Y---------------------KNG--------------------------LAYKKKAAV DR2174 W---------------------KRG--------------------------LAYKKGGLV BS_leuS Y---------------------EKG--------------------------LAYVDEVPV BH3281 Y---------------------NKG--------------------------LAYIDEVAV L0352 Y---------------------EKG--------------------------LAYEAEVAV SPy0173 Y---------------------EKG--------------------------LAYEAEVPV TP0586 Y---------------------EKG--------------------------LAYEATAPI BB0251 Y---------------------KKG--------------------------LAYVKEMPV MG266 F---------------------KAN--------------------------LAELVDIDV MPN384 F---------------------EAG--------------------------LAEVKEIDV UU371 Y---------------------KHN--------------------------LAEIQDIDV CT209 Y---------------------EKG--------------------------LAYMADMAV CPn0153 Y---------------------DQG--------------------------LAYMADMAV Rv0041 YNAWFDTTANKARPISELVAEFESGARCLDGGRDWAKLTAGERADVIDEYRLVYRADSLV ML0032 YNAWFDVAANKARPIAELIAEFDSGERRLVDGRDWATLSAGERADVIDNCRLVYRADSMV PH0965 K---------------------EKG--------------------------YIVKGAHRV PAB1782 K---------------------EKG--------------------------YIVKGAHRV MJ0633 K---------------------EKG--------------------------LIVKGSHPV AF2421 K---------------------ELG--------------------------LIVKGTHPV MTH1508 R---------------------DLG--------------------------LVRKGAHPV Ta0777 N---------------------EKG--------------------------LVKQGRYPI TVN0761 N---------------------EKG--------------------------LIKQDKYPI APE1015 R---------------------EKG--------------------------FVGKGRHPV YLR382c F---------------------ENG--------------------------LAYRKEAEI aq_1770 ------------------------------------------------------------ YPL160w K---------------------AAG--------------------------KIKFGERYT leuS NWCPNDQTVLANEQVI----DGC--CWRCDTKVERKEIPQWFIKITAYADEL------LN ZleuS NWCPNDQTVLANEQVI----DGC--CWRCDTKVERKEIPQWFIKITAYADEL------LN VC0956 NWCPNDQTVLANEQVE----DGC--CWRCDTPVEQKEIPQWFIKITAYAQEL------LD HI0921 NWCPNDETVLANEQVH----EGC--CWRCDTPVEQKEIPQWFIKITDYAEQL------LG PM1214 NWCPNDETVLANEQVH----EGC--CWRCDTPVEQKEIPQWFIKITDYAEQL------LG NMB1897 NWDPVDQTVLANEQVI----DGR--GWRSGALIEKREIPMYYFKITDYAEEL------LN NMA0559 NWDPVDQTVLANEQVI----DGR--GWRSGALIEKREIPMYYFKITDYAEEL------LN PA3987 NWDPVDQTVLANEQVI----DGR--GWRSGALIEKREIPMYYFKITAYAEEL------LE XF2176 NWDPVDQTVLANEQVI----DGR--GWRSGAPVEKREIPQWFLRITDYAQEL------LD BU444 NWCSYDKTVLANEQVI----DGC--CWRCQNKIRIKQIPQWFIKIRNYAESL------YQ jhp1452 NWCPNDKTVLANEQVI----DGR--CWRCDTEVIQKELYQYYLKITNYAEEL------LK HP1547 NWCPNDKTVLANEQVI----DGR--CWRCDTEVIQKELYQYYLKITNYAEEL------LK Cj1091c NWCEQDQTVLANEQVE----DGK--CWRCGHEVVQKKMPGYYVKITAYAEEL------LK mll4077 NWDPEDMTVLANEQVI----DGR--GWRSGALVEQRELTQWFFKITDFAQDL------LD CC3749 NWDPVDMTVLANEQVI----DGK--GWRSGAVVEKRKLTQWFLRITDYADAL------ID RP421 NWDPVDNTVLANEQVV----DGR--GWRSGAIIEKRYLKQWFLKITDYAEEL------LN VNG2223G NWCPSCETVLADEQVE----GDDELCWRCDTPVTERDLDQWFFETTAYADEL------LD aq_351 NWCPHDQTVLANEQVI----EGK--CWRCGTPIVQKEVPSWFLRITAYADRL------LE sll1074 NWDPIDQTVLANEQVDS---EGR--SWRSGAMVERKLLRQWFLKITDYAEAL------LN TM0168 NWCPKCKTVLANEQVK----DGK--CERCGTSVTIRHLEQWFFKITDYAERL------LN DR2174 NWCPKDQTVLANEQVV----NGH--CERCGTAVERRNLSQWYLKITDYAEEL------LD BS_leuS NWCPALGTVLANEEVI------DGKSERGGHPVERRPMKQWMLKITAYADRL------LE BH3281 NWCPALGTVLANEEVI------DGKSERGGHPVERRPMKQWMLKITEYADRL------LE L0352 NWVEELGTAIANEEVLP-----DGTSERGGYPVVRKPMRQWMLKITAYAERL------LE SPy0173 NWVEELGTAIANEEVLP-----DGTSERGGYPVVRKPMRQWMLKITAYAERL------LE TP0586 NWCPSCKTGLANEEVR------DACCERCGAEVTRRGVRQWMVRITAYAERL------LS BB0251 WYCPELGTVLANEEIIQT-SD-GPKSERGSYSVEKKYLRQWVLKITKYAERL------LD MG266 NWCEQLGTVLANEEVLID-SNGNAVSERGSFSVEKRKMKQWVLKITTFADAL------LE MPN384 NWCAELGTVLANEEVLID-SNGNAVSERGEFPVTKRKMKQWVLKITAFAESL------LN UU371 NWCENLGTVLSNEEVVLN-DKNERVSERGGHPVVRKPMKQWVLKIVDYADKL------LD CT209 NYCPELGTVLSNEEIEN------GFSVDGGYPVERRMLRQWVLRITAFADQL------LE CPn0153 NYCPELGTVLSNEEVEN------GFSIEGGYPVERKMLRQWILKITAYADKL------LE Rv0041 NWCPGLGTVLANEEVTA-----DGRSDRGNFPVFRKRLRQWMMRITAYADRL------LD ML0032 NWCPGLGTVLANEEVTA-----DGRSDRGNFPVFRKRLRQWMMRITAYADRL------LD PH0965 RWDPVVGTPLGDHDLMEG------------EDVPILDYIIIKFELRENGEVI------YL PAB1782 RWDPVVGTPLGDHDLMEG------------EDVPILEYVIIKFELKEGDETI------YL MJ0633 RYCPRCDNPVEDHDILVG------------ENATLVEYILIKFTTEDG---C------IM AF2421 RYCPHDQNPVEDHDLLAG------------EEATIVEFTVIKFRLEDGD--L------IF MTH1508 KYCPECENPVGDHDLLEG------------EGVAINQLTLLKFKLGDS----------YL Ta0777 LYSLEDDNAVGEDDIKDGD----------TDKVTIEEYTAIFFRGKSFD----------L TVN0761 LYSIDDDNAVGEDDIKDGD----------TDKVSVEEYTAVFFESNSYS----------L APE1015 VWCPKEQKVVGDHDRP-----------DEYAGISPQEAVIIKFRGRDG---L------VY YLR382c NWDPVDMTVLANEQVDAQ---GR--SWRSGAIVEKKQLKQWFLGITKFAPKL------KK aq_1770 ------------------------------------------------------------ YPL160w IYSEKDGQACMDHDRQSG--EGVTPQEYIGVKIEALEFADDAAKIIDSSSDLDKSKKFYF leuS DLDKLD-HWPDTVKTMQRNWIGR-SEGVEITFNVNDYDNTL------------------- ZleuS DLDKLD-HWPDTVKTMQRNWIGR-SEGVEITFNVNDYDNTL------------------- VC0956 DLDNLD-GWPEMVKTMQRNWIGR-SEGVELKFAVKGENTDL------------------- HI0921 GLDTLP-QWPDMVKTMQRNWIGR-SEGVEITFDVANTNEKV------------------- PM1214 GLDHLP-LWPDQVKTMQRNWIGR-SEGVEITFQLANSEDNL------------------- NMB1897 DLDKLE-HWPEQVKTMQRNWIGK-SRGMTVRFAVSDDSKQGLEG------------DYAK NMA0559 DLDKLE-HWPEQVKTMQRNWIGK-SRGMTVRFAVSDDSKQGLEG------------DYAK PA3987 SLDNLP-GWPEQVKTMQRNWIGK-SRGMEIGFPY-DQASIG----------------HAG XF2176 GLNTLD-DWPEPVKTMQRNWIGR-SEGLEIQFEVRDADNNA-----------------LE BU444 DLKKLT-HWPENVKNMQRNWIGR-IKGFEITLNVFNTCQKL------------------- jhp1452 DLETLENHWPSQVLTMQKNWIGK-SSGLQFGFKIADECLKACNN------------IQE- HP1547 DLEALEDHWPSQVLIMQKNWIGK-SSGLQFGFKIADECLKACNG------------IQE- Cj1091c DLEELKDKWPNQVLTMQENWIGK-SEGLEFSLNLDEES-KQKTK------------ESS- mll4077 SLEGLD-EWPEKVKLMQQNWIGR-SEGLLIRWPLASDVAG------------------EH CC3749 GLKTLD-RWPDKVRLMQENWIGR-SKGLRFKFQFDGEAPDG----------------MAE RP421 EIQNLK-DWPAAVRVMQEEWIGK-STGVNFHFKVKYHENT-------------------- VNG2223G GLDELDG-WPSNVRDMQRNWVGR-TDGVEVPFTVHTPDGD----------------ED-- aq_351 DLKKLEGKWPERVIAQQRNWIGR-SEGALIRFYVEIEEPEKFLNCVPEELKETLLKEKRI sll1074 DLEQLT-GWPERVKLMQSHWIGK-SVGAYLEFPIKDSQEK-------------------- TM0168 DLDKLT-GWPEHVKTMQRNWIGK-STGAEIDFPVEGSDTK-------------------- DR2174 FSATDM---PEKVRAMQTNWIGK-SVGAEVTFDTPAGPET-------------------- BS_leuS DLEELD--WPESIKDMQRNWIGR-SEGAHVHFAIDG---------------------HDD BH3281 DLEELD--WPESIKDMQRNWIGR-SEGAEVTFSVDG---------------------HDD L0352 DLEEVD--WPESIKEMQRNWIGK-SVGADVTFEVAG---------------------TDK SPy0173 DLEEVD--WPESIKDMQRNWIGK-STGANVTFKVKD---------------------TDK TP0586 DLDELD--WPESVKQMQRNWIGK-SCGAEIDFPVDAPACSVHDK-------------LPQ BB0251 DLEELE--WPESVKEMQRNWIGK-STGVEIEFEIEG---------------------HSD MG266 GLDTLD--WPEPIKEMQRNWIGK-SKGVTINFQLKD---------------------HKE MPN384 GLAELD--WHQSIKEMQTNWIGK-SEGVEVTFDIEN---------------------SKE UU371 GLNEVE--FSESLKSLQRNWIGK-SIGTSVQFKIKD---------------------SLL CT209 GLDELD--WPESVKQLQKNWIGK-SSGASVNF-ATE----------------------HG CPn0153 GLDALD--WPENVKQLQKNWIGK-SEGALVTFHLTQ----------------------EG Rv0041 DLDVLD--WPEQVKTMQRNWIGR-STGAVALFSARAASDDG----------------FEV ML0032 DLDLLD--WPEQVKTMQRNWIGR-SSGATVLFSAILSRSDAAT--------------TEV PH0965 PAATLR---PETVYGVTNMWVNPNATYVKAKVRRKDKEE-----------------TWIV PAB1782 PAATLR---PETVYGVTNMWINPNATYVKAKVKRGGKEE-----------------TWII MJ0633 PMATLR---PETVFGVTNVWVNPEATYVKAKVYLEKETENGIEL--------IENGIWIM AF2421 PCATLR---PETVFGVTNIWVKP-TTYVIAEVDGEK---------------------WFV MTH1508 VAATFR---PETIYGATNLWLNPDEDYVRVETGGEE---------------------WII Ta0777 IAASLR---PETIYGITNIWVNPDVKYVKVKISGRM---------------------AVV TVN0761 IAASLR---PETLFGVTNIWINPTGEYVKIKIGDKI---------------------AVV APE1015 PALTYR---PETVFGVTNLWVHPDATYLVAEVDGEER--------------------WII YLR382c HLNQLK-DWPSNVKQMQKNWIGE-SVGAELVFKVADPKFEN------------------- aq_1770 ------------------------------------------------------------ YPL160w VAATLR---PETMYGQTCCFVSPTIEYGIFDAGDSYFITTER----------------AF leuS --TVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNP-------------ELAAFIDECRNT ZleuS --TVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNP-------------ELAAFIDECRNT VC0956 --EVYTTRPDTLMGVTYVGIAAGHPLATKAAANNP-------------ALAAFIDECKNT HI0921 --AVYTTRPDTFYGVSYLGIAAAHPLASLAAQNNS-------------ELAAFIQEAKNA PM1214 --TVYTTRPDTFFGVSYVAVAAAHPLAEKAAENNP-------------ELAQFIQECKNT NMB1897 FLQVYTTRPDTLMGATYVAVAAEHPLAAAAAADKP-------------ELQAFIAECKAG NMA0559 FLQVYTTRPDTLMGATYVAVAAEHPLATAAAADKP-------------ELQAFIAECKAG PA3987 QLKVFTTRPDTLMGATYVAVAAEHPLATQAAQNDP-------------QLQAFIDECKRG XF2176 ALRVFTTRPDTLLGVTFVSIAAEHPLALHAAKSNP-------------ALAGLLTEMKQG BU444 --KVFTQRLDLLMGVTYISISSCHKLSINLSKKNE-------------LIKKFIKKYR-- jhp1452 -IEVFTTRADTIYGVTYIAIAPEHPLVEHAIKR---------------VSQEDSKMIKAI HP1547 -IEVFTTRADTIYGVTYIAIAPEHPLVEHAIKQ---------------VSQEVSKMIKAI Cj1091c -LEVFTTRADTIYGVSYIALAPEHKIVQNLLSQNL-------------LNQDVLNKIKVI mll4077 ELEVYTTRPDTIFGASFMAVAADHPLAKKAAETNP-------------ALAKFIDEVRHM CC3749 GLEVYTTRPDTLFGASFVGIAPEHPLAEQLAAANP-------------QIQTFIADCRKG RP421 TIEVFSTKPETIFGASFIGIAFNHPIIEQLICKTP-------------EIVNFITKCSYI VNG2223G -VVAFTTRVDTIHGATYFALAPDHPLAEAAADRDD-------------DVAHFVEEVADP aq_351 YIDVFTTRPDTVFGATFVVLAPEHPLVPVLACIGERLGNACY-----SDVENFVEKMKKM sll1074 -IAVFTTRPDTVYGVTYVVLAPEHPLTKVVTTAEQQG-----------TVDEFVAMVAKE TM0168 -IRVFTTRPDTLWGVTFMALAPESPLVEELVPEEKKE-----------ELQEFLERVKQQ DR2174 ---VFTTRPDTLMGATFMVLAPEHAKVKELTTDEQR-----------AEVEAYVAAAGRK BS_leuS SFTVFTTRPDTLFGATYTVLAPEHALVENITT---------------AEQKEAVEAYIKE BH3281 TITVFTTRPDTLFGATYMVLAPEHKLVDAITT---------------SEQKQAVESYKKE L0352 SFEVFTTRPDTLFGATYAVLAPEHDLVDAITT---------------PEQKEAVAEYRRK SPy0173 DFTVFTTRPDTLFGATYAVLAPEHALVDAITT---------------ADQAEAVAKYKRQ TP0586 TIRVYTTRADTLFGVTYLVLAPEHEAVTALTT---------------HAQRAAVQAYVQR BB0251 KIKVFTTRPDTIFGITYLVIAPENKLIEKITK---------------NNFKQNVLKYVKH MG266 AIAIFTTKPQTIFGVSFLAVSTNHWLAKKIA----------------ETNKKVASFLKKQ MPN384 TITIFTTKVQTIFGVTFLALSNSHPLVKEVA----------------KTNPKIAQFLQKQ UU371 TLDVFTTRIDTIYGVQYLVVAPEHPILKSITS---------------EQQINVVQSYIEQ CT209 VIEVFTTRPDTLIGVSFLALAPEHPLVDLLTS---------------DEQKAVVAQYIKE CPn0153 SLEAFTTRLDTLLGVSFLVIAPEHPDLDSIVS---------------EEQRDEVTAYVQE Rv0041 DIEVFTTRPDTLFGATYLVLAPEHDLVDELVAASWPAGVNPLWTYGGGTPGEAIAAYRRA ML0032 DVEVFTTRPDTMFGVTYLVLAPEHNLVDELVATVWPDRTDPRWTYGAATPGAAVAAYRRA PH0965 SKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVS----------GDEVIILPAEFVDP PAB1782 SKEAAYKLSFQDREIEVIEEFKGEKLIGKYVRNPVT----------GDEVIILPAEFVDP MJ0633 AKECAEKLKHQDRKIEIIEEFKGEQLINKKVKNPVT----------GKEVPILPAKFVKT AF2421 SKEAYEKLTYTEKKVRLLEEVDASQFFGKYVIVPLV----------NRKVPILPAEFVDT MTH1508 SRAAVDNLSHQKLDLKVSGDVNPGDLIGMCVENPVT----------GQEHPILPASFVDP Ta0777 SEECSTKLKFQGNEIEVAGEASVQEIQKQTYTTPA-----------GKEVKVYQADFVDP TVN0761 SKEAVDKLKYQRNDVSVIGPISAESIQRKKFTTPF-----------GKEVPVYKADFVDT APE1015 GEQAARELADQGHRVVILERIEGRRLLGRIVVNPAD----------GREVPVLPASFVRP YLR382c -LIVFTTRPETLFAVQYVALALDHPIVQKYCEEMP-------------DLKEFIQKSDQ- aq_1770 ------------------------------------------------------------ YPL160w KNMSYQKLTPKRGFYKPIVTVPGKAFIGTKIHAPQS---------VYPELRILPMETVIA leuS --KVAEAEMAT--MEKKGVDTGFKAVHPLTG---------EEIPVWAANFVLMEYG---- ZleuS --KVAEAEMAT--MEKKGVNTGFKAVHPLTG---------EEIPVWAANFVLMEYG---- VC0956 --KVAEAEIAT--MEKKGMATGLTAIHPLNG---------REVPIYIANFVLMDYG---- HI0921 --KVAEADLAT--MEKKGMATGLFAIHPLTG---------DKLPIWVANFVLMHYG---- PM1214 --KVAEAELAT--MEKKGMATGVYAIHPLTG---------EKVPVWVANFVLMHYG---- NMB1897 --SVAEADMAT--MEKKGVPTGRYVVNPLNG---------DKLEVWIANYVLWGYG---- NMA0559 --SVAEADMAT--MEKKGVPTGRYVVNPLNG---------DKLEVWIANYVLWGYG---- PA3987 --GVAEADIAT--QEKKGMATSLFVEHPLTG---------DKLPVWVANYVLMNYG---- XF2176 --GLSEAELKT--QEKRGMDTGLKAIHPITN---------EQLPVWVANFVLMAYG---- BU444 --YISQEEQYK--VKYTGINTNLFVVHPITK---------KTIPIWISNATHIEYG---- jhp1452 -LNTTQRER-A--LEKKGAFLGIYAIHPLTK---------QKIPVWVANFALANYG---- HP1547 -LNTTQRER-A--LEKKGAFLGIYAIHPLTK---------QKIPVWVANFALANYG---- Cj1091c -QNQSPRERQS--SEKEGYFLGIYAIHPLSG---------EKIPLWVANFVLADYG---- mll4077 G--TSVAALET--AEKKGFDTGIRVVHPFDDS--------WTLPVYVANFVLMEYG---- CC3749 G--TSEAEIES--AEKLGYDTGLRVKHPLDPS--------ITLPVWIANFILMDYG---- RP421 ---TRSSEIDK--AEKEGIFSGLYVIHPFDAN--------IFLPVIITNFVLMDYG---- VNG2223G ---DGDE--------PQGVETEFTATNPATG---------AEIPVVVADFVLSDVG---- aq_351 ---STRERTME--EDKEGVFLGVYATNPANG---------EKIPVWSANYVLYEYG---- sll1074 --SEIERTAED--KPKRGVKTGGIAINPFNG---------EEIPILIADYVLYEYG---- TM0168 --DRFRRTSVE--AEKEGFFLGRYAINPVTG---------ERIPIYVANYILMEYG---- DR2174 ---TDVERQQE--GEKTGVFTGSYATHPISG---------HQLPIWVADYVLVTYG---- BS_leuS IQSKSDLERTDLAKTKTGVFTGAYAINPVNG---------EKLPIWIADYVLASYG---- BH3281 VATKSDLERTELAKEKTGVFTGAYAINPVNG---------EKVPIWIADYVLVSYG---- L0352 ASLKSDLARTDLSKEKTGAFTGAYAINPING---------RKMPIWVADYVLASYG---- SPy0173 ASLKSDLARTDLAKEKTGVWTGAYAINPVNG---------NEMPVWIADYVLASYG---- TP0586 AAKKNDLERTDLAKEKTGVFTGAYVRNPIND---------MRIPVWVGDYVLVSYG---- BB0251 EELKSDLNRTSLEKDKSGVFTGSYAFHPITN---------EKIPIWVGSYVLGTYG---- MG266 LQKTTTLKQKA--TLYDGIDLLTNAIHPLTN---------ELIPVYVANYVIEGYG---- MPN384 AQKTTTVKQPE--TLHDGVDLKLKAINPATN---------TAIPLYVANYVVEGYG---- UU371 TKKISDLDRIAD-TNKTGVFSGAYAINPINQ---------EIIPIWVSDYVLMNFA---- CT209 TQSKSERDRISEMKTKSGVFTGSYAKHPVTH---------KLIPIWIADYVLIGFG---- CPn0153 SLRKSERDRISSVKTKTGVFTGNYAKHPITG---------NLLPVWISDYVVLGYG---- Rv0041 IAAKSDLERQE-SREKTGVFLGSYAINPANG---------EPVPIFIADYVLAGYG---- ML0032 IVAKSDLDRQE-SKEKTGVFLGRYATNPATG---------KPVPIFVADYVLVGYG---- PH0965 DNATGVVMSVPAHAPFDHVALEDLKRETEILEKYDIDPRIVENITYISLIKLEGYGDFPA PAB1782 DNATGVVMSVPAHAPFDHVALEDLKRESEILVKYDIDPRIVEEITYISLIKLEGYGEFPA MJ0633 NIGTGCVMSVPAHAPYDYIALRDLG--------------LVDEIGLIPLINVPGYGKYPA AF2421 DNATGVVMSVPAHAPFDLAAIEDLKRDEETLAKYGIDKSVVESIKPIVLIKTDIEG-VPA MTH1508 EYATGVVFSVPAHAPADFIALEDLRTDHELLERYGLED-VVADIEPVNVIAVDGYGEFPA Ta0777 DNGTGIVYSVPSHSVYDYVYYRKKR---------------GK-DFPV-IIEAPMKM---- TVN0761 DNGTGVVYSVPSHSVYDFVYYRRKK---------------SG-QTPV-VIEAPLKM---- APE1015 DLGTGVVMSVPAHAPYDYVALMELKRRPETLREYGLEPGVVESLEPIQLIAVPRAEGLLV YLR382c ------LPNDT---KEGFQLPNIKAVNPLTK---------EEVPIFAAPYVVSSYG--SA aq_1770 ------------------------------------------------------------ YPL160w TKGTGVVTCVPSNSPDDYITTKDLLHKPEYYG----IKPEWIDHEIVPIMHTEKYGDLTA leuS TGAVMAVPGHDQRD---YEFASK--YGLNIKPVILAAD---------------------- ZleuS TGAVMAVPGHDQRD---YEFASK--YGLNIKPVILAAD---------------------- VC0956 TGAVMAVPAHDQRD---FEFATK--YGLDIIPVIKPAD---------------------- HI0921 TGAVMAVPAHDQRD---FEFAQK--YSLPIKQVIAPLA---------------------- PM1214 TGAVMAVPGHDERD---AEFARK--YGLPLLNVIKPIN---------------------- NMB1897 DGAVMAVPAHDERD---FEFATK--YNLPKKQVIAVG----------------------- NMA0559 DGAVMAVPAHDERD---FEFAAK--YSLPKKQVLQRVTIGLSPEQEEAMGFGGGSGCGAG PA3987 EGAVMAVPGHDERD---FEFANK--YGLPIRQVIAKVE---------------------- XF2176 TGAVMAVPGHDQRD---QEFANK--YGLPIRQVIALKE---------------------- BU444 TNAVLSIPGHNEND---WNFAVK--NNLKIKYVIFNPD---------------------- jhp1452 SGALMGVPACDERD---FEFANL--YHIPIKVITQSP----------------------- HP1547 SGALMGVPACDERD---FEFANL--YHIPIKVITQSP----------------------- Cj1091c SGAVMAVPAHDERD---FEFATK--YNLAIKQVIQTQ----------------------- mll4077 TGAIFGCPSGDQRD---LDFANK--YGLPVIPVVMPEG---------------------- CC3749 TGAIFACPAHDQRD---LDFARK--YDLPVLPVVLPNG---------------------- RP421 TGAIFGCPAHDKRD---HELAIK--MNLPIKQVIETG----------------------- VNG2223G TGALMAVPAHDDRD---HEFAQA--HDLPVRQVVAPAGD--------------------- aq_351 TGAIMCVPAHDQRD---WEFAKK--YDLPIKVVVKPEG---------------------- sll1074 TGAVMGVPAHDQRD---FKFAQD--NNLPMQVVIIPDD---------------------- TM0168 TGAIMGVPAHDQRD---FSFAKK--YGIPIKVVIKPAD---------------------- DR2174 TGSIMAVPAHDERD---FAFAKK--FDLPIREVIRAEG---------------------- BS_leuS TGAVMAVPGHDERD---FEFAKT--FGLPVKEVVKG------------------------ BH3281 TGAIMAVPAHDERD---YEFAKT--FDLPIKEVVSG------------------------ L0352 HGAVMAVPAHDERD---WEFAKV--YGLEILPVVEG------------------------ SPy0173 TGAIMAVPAHDERD---WEFAKQ--FKLDIIPVLEG------------------------ TP0586 TGAVMAVPAHDQRD---WDFATR--FGLPKLTVVSADYTATVPNSN-------------- BB0251 TGAVMGVPAHDERD---FQFAKK--YQLKILPVISK------------------------ MG266 TDAIMGVGAHNEND---NFFARK--QKLKIINVIDK------------------------ MPN384 TDAVMGVPAHNEND---NFFARK--QKLPIITVIDK------------------------ UU371 TGAVMGVPAHDERD---YAFAKK--YALPIKSVIDT------------------------ CT209 SGAVMGVPAHDERD---LLFAEQ--FNLPVVSVLNK------------------------ CPn0153 TGVVMGVPAHDERD---REFAEM--FSLPIHEVIDD------------------------ Rv0041 TGAIMAVPGHDQRD---WDFARA--FGLPIVEVIAG------------------------ ML0032 TGAVMAVPGHDPRD---WDFAHK--FHLPIVEVIAG------------------------ PH0965 VEEVNKLGIKSQKDKEKLEQATK--TIYKAEYHKGIF----------------------- PAB1782 VEEVQKLGIKSQKDREKLEQATK--TIYKAEYHKGIF----------------------- MJ0633 KEIVEKMGIKSQEEEDKLEEATK--KIYKDEFHKGVLNE--------------------- AF2421 EKLIRELGVKSQKDKELLDKATK--TLYKKEYHTGIMLD--------------------- MTH1508 AEVIEKFGVRNQED-PRLEDATG--ELYKIEHARGVMSS--------------------- Ta0777 KDIESKYDLETEEG---REEATK--DLYRNEFYYGKLV---------------------- TVN0761 PEVEIKFDLNSKEG---LDEATK--ELYKSEFYYGKLV---------------------- APE1015 VEEVRRRGVESQMDREKLDEATR--EVYAREFYEGIMLET-------------------- YLR382c PSAVMGCPGHDNRD---FEFWQTNCPGEHIKTCIAPFFDDASKVTE-------------- aq_1770 ------------------------------------------------------------ YPL160w KAIVEEKKIQSPKDKNLLAEAKK--IAYKEDYYTGTMIYG-------------------- leuS -------G-----SEPDLSQQALTEKGV---LFNS-GEFNGLDHEAA-FNAIADKLTAMG ZleuS -------G-----SEPDLSQQALTEKGV---LFNS-GEFNGLDHEAA-FNAIADKLTAMG VC0956 -------G-----SELDVSEAAYTEKGV---LFAS-GEFDGLDFQAA-FNAIAAKLEAEG HI0921 -------D-----EEIDLTKQAFVEHGK---LVNS-DEFDGKNFDGA-FNGIADKLEKLG PM1214 -------G-----EPLLEHELPYCEHGI---LFNS-GEFNGLDFDAA-FNAIADKLEALG NMB1897 ----------DNAFDENQWQEWYGDKEN-GVLVNS-GDLDGLDFQTA-FDAVAAKLQSQG NMA0559 YGDGSGSDSRDLPFMPNKWQAWYGVKDDFMVLINS-GELDGMNYQTA-FDAVAAKLQAIG PA3987 ----G-----DNDFESSVWKEWYGAKDESVLTVNS-GKYDNLGYQAA-FDAIGADLEAKG XF2176 --P---KNQDESTWEPDVWRDWYADKTREFELINS-AEFDGLDYQDA-FEVLAERFERQG BU444 ------------HQEPKLYTSFLDIKGT---LFNS-QEFNGLNLKDG-TEKIKKILYKKK jhp1452 ----------------QNLPHT-----KEEILKNS-GEWSDLSSSVA-REKIIAYFEKEN HP1547 ----------------QNLPHT-----KEEVLKNS-GEWSDLSSSVA-REQIIAYFEKEN Cj1091c ----------------ENLPYMQ----KLGKLINS-QEFDNLDCNEA-RLKIISQFEAKN mll4077 -------------GDAKSFQITEEAYVDDGVMINS-RFLDGMKPDRA-FDEVAKLLEQKT CC3749 -------------EDPATFTVGKEAYVGPGKIFNS-KFLDGLDVEAA-KAEAIARIEAAN RP421 --------------N-----------IQEGILINS-DWLNGLTSSEA-KQKVIEKFEKLG VNG2223G ----------------EDADVEAAAYTADGVLVNA-GDYTGLDSETA-REELTADIDG-- aq_351 -----------------AWDFEKGAYEGKGTLVNS-DGFDGLDSETA-KRKITEWLQDRG sll1074 --------------ADNSDVNLTVAYTEAGVMVNS-AQFTGMASPKA-KQAIIKFAEDND TM0168 --------------KDLDPEKMEEAYEGEGIMVNS-GPFDGTPSSEG-IEKVINWLEEKG DR2174 -------------SE-GMGDQPSEPYSGEGQIVNS-GEFDGMPGGKASIAAIIARLEERG BS_leuS ------------------GNVEEAAYTGDGEHVNS-DFLNGLHKQEA-IEKVIAWLEETK BH3281 ------------------GVIEQEAYTGDGPHVNS-EFLNGLSKEEA-IEKMIQWLEAEK L0352 ------------------GNVEEAVYTEDGPHINS-EFLNGLDKAQA-IEKAIEFLEEKK SPy0173 ------------------GNVEEAAFTEDGLHINS-GFLDGLDKASA-IAKMVEWLEAEG TP0586 ---------------SPQGAVLQRCVSDEGFVVNS-GAFNGLASADA-RERIVAHLEMRG BB0251 ---------------SGKNEILEKAFVDDGISINSPNEFNNLKNSEV-KDKVIKWLTKNK MG266 --------------------KERLQ--------NS-FAYNGLTTKEA-QVAITNELISQN MPN384 --------------------QERLQ--------HS-GQFSGLNSQTA-NTQITQMLVERQ UU371 --------------------KQKLPYAGDGLHINS-AMINGLNIKQS-QNVLNDYLIKNH CT209 ------------------EGVCINS------CCEG-FHLDGLSGEEA-KQYVINFLEENH CPn0153 ------------------NGVCIHS------NYND-FCLNGLSGQEA-KDYVINYLEMRS Rv0041 ------------------GNISESAYTGDGILVNS-DYLNGMSVPAA-KRAIVDRLESAG ML0032 ------------------SDISEAAYVGDGVLVNS-GYLDGMDVATA-QEAITARLESEG PH0965 --------------KVPPYEGKPVQEVKEAIAKEMLEKGIAEIMYEFAEKNVISRFGNRA PAB1782 --------------KVPPYDGKPVQEVKELIAKEMMEKGIAEIMYEFAEKNVISRFGNRA MJ0633 --------------NCLDYEGIPVREIKDKLTKDLIDKGLAEIMYEFSEEKVICRCGTPC AF2421 --------------NTMNYAGMKVSEAKERVHEDLVKLGLGDVFYEFSEKPVICRCGTKC MTH1508 --------------HIPVYGGMKVSEAREVIADELKDQGLADEMYEFAERPVICRCGGRC Ta0777 --------------DSGPYTGMTVREAREAVKRDLISSGNAFTFYETS-RHAVTRSGSKV TVN0761 --------------NSGEYTGLTVRDAREKIKKDLIGSGKAIIFYETS-RKAVTRGGSKV APE1015 ---------------TGRFSGLKVAEAKEKVVEWLEERGAALRIYTL-PQEVYCRCGART YLR382c -------------QERQRIIDTVPFTSTDGVLTKECGEHSGVLTVVA-RKSIMGMLNSEG aq_1770 ------------------------------------------------------------ YPL160w -----------------PYKGEKVEQAKNKVKADMIAAGEAFVYNEP-ESQVMSRSGDDC leuS VG-----ERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPED-VVMD ZleuS VG-----ERKVNYRLRDWGVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPED-VVMD VC0956 KG-----KKTVNFRLRDWGVSRQRYWGAPIPMVTTEDGQVHPVPADQLPVILPED-VVMD HI0921 VG-----KRQVNYRLRDWGVSRQRYWGAPIPMLTLENGDVVPAPMEDLPIILPED-VVMD PM1214 KG-----KRQVNYRLRDWGVSRQRYWGAPIPMLTLENGEVVPAPLQDLPIELPED-VVMD NMB1897 AG-----EPKTQYRLRDWGISRQRYWGCPIPIVHCEQCGDVPVPADQLPVVLPEN-VVPD NMA0559 AG-----EPKTQYRLRDWGISRQRYWGCPIPIVHCEQCGDVPVPADQLPVVLPEN-VVPD PA3987 LG-----QARTQFRLRDWGISRQRYWGCPIPIIHCEACGDVPVPADQLPVVLPED-VVPD XF2176 RG-----QRRVNYRLRDWGVSRQRYWGCPIPVIYCPTCGAVPVPEDQLPVILPEN-VAFS BU444 IL-----KEKINYKLQDWCISRQRYWGTPIPMAKFKNGKMIPIPENQLPVVLPKIRKNTN jhp1452 LG-----KRVINYRLQDWGVSRQRYWGAPIPMIHCKHCGIVPET--QLPVTLPED-IVID HP1547 LG-----KRVINYRLQDWGVSRQRYWGAPIPMIHCNHCGIVPET--QLPVTLPED-IVID Cj1091c IG-----KRVVNFKIRDWGVSRQRYWGAPIPMIKCQSCGIVPQKLENLPITLPED-VQIT mll4077 IGNRPMAERKVNFRLRDWGISRQRYWGCPIPMIHCEDCGVVPVPKADLPVKLPDD-VDFD CC3749 QG-----QGATVYRLRDWGVSRQRYWGCPIPVIHCEACGVVPVPEDQLPVALPDD-VTFD RP421 IG-----KRSVNYRLKDWSISRQRFWGCPIPMIHCKTCGVVPVPYKDLPVTLPDD-VSFD VNG2223G -A-----ASAVQYQLRDWGVSRQRYWGTPIPIVHCESCGPVSVPDDDLPVELPEF-VHTT aq_351 LG-----EKKVSYRLRDWNISRQRYWGTPIPVVYCEKCGMVPVPEDQLPVKLPLD-VKFT sll1074 YG-----RAKVQYRLRDWLISRQRYWGCPIPIIHCDDCGAVPVPTKDLPVELPDN-VEFS TM0168 IG-----KRSVQYKLRDWLISRQRYWGAPIPIIYCEKCGVVPVPEEDLPVRLPKD-VEFL DR2174 VA-----KAKTTYRLRDWLFARQRYWGTPIPFVHCEKCGMQPVPEDQLPVKLPEN-VAFT BS_leuS NG-----EKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILPKTDEIKP BH3281 KG-----TKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTMSTVPEDELPLELPKMSEIKP L0352 IG-----KKKITYRLRDWLFSRQRYWGEPIPIIHWEDGTSTALSEDELPLVLPVTSDIKP SPy0173 VG-----NEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRP TP0586 AG-----ARRVTYRLRDWVFSRQRYWGEPIPLVHCPSCGVVPLPESALPLLLPETADFTP BB0251 KG-----KEKVAYKLRDWIFSRQRYWGEPIPILFDKLGNAIPLEENDLPLKLPEIANYKP MG266 KA-----KLTTVYKLRDWIFSRQRYWGEPFPIIFDENNTPHLVEQ--LPVELPLLENYKP MPN384 KA-----KKTTVYKLRDWIFSRQRYWGEPFPILFDENNQPHLVKE--LPVTLPALANYQP UU371 LG-----KKVANYKLRNWIFSRQRYWGEPFPVLFDENNQIKIIED--LPVLLPNLNEFKP CT209 LG-----AAKIAYKLRDWLFSRQRYWGEPIPIIHFEDGSCRPLRDYELPLLPPEIQDYRP CPn0153 LG-----RAKTMYRLRDWLFSRQRYWGEPIPIIHFEDGTHRPLEDDELPLLPPNIDDYRP Rv0041 RG-----RARIEFKLRDWLFARQRYWGEPFPIVYDSDGRPHALDEAALPVELPDVPDYSP ML0032 RG-----HARIEFKLRDWLFARQRYWGEPFPIIYDSDGRPHALDEAALPVELPDVPYYSP PH0965 VIKIIHDQWFIDYGNPEW-KEKARKALERMKILPETRRAQFEAIIDWLDKKACARKIGLG PAB1782 VIKIIHDQWFIDYGNSEW-KEKARKALARMKIYPETRRAQFEAIIDWLDKKACARKVGLG MJ0633 IVKMVKGQWFIKYSDEKW-KELAHKCIDKMRFIPENLRQVFHEKIDWMKDKACVRRRGLG AF2421 VVKVVRDQWFLNYSNREW-KEKVLNHLEKMRIIPDYYKEEFRNKIEWLRDKACARRKGLG MTH1508 VVRVMEDQWFMKYSDDAW-KDLAHRCLDGMKIIPEEVRANFEYYIDWLNDWACSRRIGLG Ta0777 IVAVLPDQWFLDYSQP-WLKDLGHTMINTMTMHPEVYRNVMNDAIDWLKERPCARRRGLG TVN0761 IVAVLPDQWFIDYSAD-WLKKLSHDMLNRMMIYPEMYRNVMNDAIDWLKERPCARRRGLG APE1015 HVKIVEDQWFLLYSKPEW-KALAREAVARMEFLPGHVRRDFEAIIEALRDWAFTHKGELG YLR382c LS-----KSVVRYKIRDWLISRQRYWGTPIPIIHCDNCGPVPVPESDLPVKLPELEGLDT aq_1770 ------------------------------------------------------------ YPL160w IVS-LEDQWYVDYGEESW-KKQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLG leuS GI---------T-SPIKADPEWAKTTVN----GMPALRETDTFDTFMES----------- ZleuS GI---------T-SPIKADPQWAKTTVN----GMPALRETDTFDTFMES----------- VC0956 GV---------T-SPIKADKEWAKTTFN----GEPALRETDTFDTFMES----------- HI0921 GV---------K-SPINADPNWAKTTFN----DAPALKETDTFDTFMES----------- PM1214 GV---------K-SPIKADPEWAKTTYN----GQPALKETDTFDTFMES----------- NMB1897 GM---------G-SPLAKMPEFYETACPCC--GGAAKRETDTMDTFMES----------- NMA0559 GM---------G-SPLAKMPEFYETTCPCC--GGAAKRETDTMDTFMES----------- PA3987 GS---------G-SPLAKMPEFYECNCPKC--GQPAKRETDTMDTFVES----------- XF2176 GT---------G-SPIKTDPEWRKTTCPEC--GGPAERETDTFDTFMES----------- BU444 LL---------Q-QAINFNSKWAEIFIH----GKHAIREIDTFDTFMES----------- jhp1452 GE---------G-NPLEKHASWKFAQCPKC--HKDALRETDTMDTFIQS----------- HP1547 GE---------G-NPLEKHASWKFTQCPKC--HKNALRETDTMDTFIQS----------- Cj1091c GE---------G-NPLDKHPTWKNCICPKC--GKEAQKESDTLDTFFES----------- mll4077 RP---------G-NPLDRHPTWRHVKCPQC--GRDARRETDTMDTFVDS----------- CC3749 KP---------G-NPLLRHPTWRHTTCPSC--GGKAERETDTLDTFIDS----------- RP421 SN---------Y-NPLEHHSSWKYVNCPKC--DNSAIRETDTFDTFFES----------- VNG2223G G------------NPLDAAEDWKQTTCPDC--GAPAVRETDTMDTFLDS----------- aq_351 GQ---------G-NPLETSEEFVNTTCPKC--GGKARRETDTMDTFFDS----------- sll1074 GR---------GPSPLAKLEDWINVPCPSC--GKPARRETDTMDTFIDS----------- TM0168 PT---------GQSPLSFHEGFKKTKCPVC--GGEAQRETDTMDTFVDS----------- DR2174 PT---------GQSPLKLDEEWKTTTCPCC--GGPAERETDTMDTFVDS----------- BS_leuS --------SGTGESPLANIKEWVEVTDPETG--KKGRRETNTMPQWAGS----------- BH3281 --------SGTGESPLANATDWLEVVDPVTG--KKGRRETNTMPQWAGS----------- L0352 --------SGTGESPLANLTDWLEVTR-ADG--LKGRRETNTMPQWAGS----------- SPy0173 --------SGTGESPLANVTDWLEVTR-EDG--VKGRRETNTMPQWAGS----------- TP0586 --------TEDGQGPLARARTWLRVPCPQCA--SDAVRETNTMPQWAGS----------- BB0251 --------SGTGESPLSRIKDWVNVKD------MGFTRETNTMPQWAGS----------- MG266 --------DGSGNSPLMRNQAWVNIVK--DN--IHYQRETNTMPQWAGS----------- MPN384 --------DGSTNPPLWRNQEWAKVKQ--GN--QTFTRETSTMPQWAGS----------- UU371 --------SKTGESPLANAQEWLYVEI--DG--KKYRRETNTMPQWAGS----------- CT209 --------EGVGQGPLAKVREWVQVFDTETQ--RAGKRETHTMPQWAGS----------- CPn0153 --------EGFGQGPLAKAQDWVHIYDEKTG--RPGCRETYTMPQWAGS----------- Rv0041 VLFDPDDADSEPSPPLAKATEWVHVDLDLGDGLKPYSRDTNVMPQWAGS----------- ML0032 VLFDPDDADSEPSPPLAKATEWVHVELDLGDGLKPYSRDTNVMPQWAGS----------- PH0965 -------------TPLPWDPEWVIESLSDS--TIYMAYYTISRHINKLRQ-----EGKLD PAB1782 -------------TPLPWDPEWVIESLSDS--TIYMAYYTISRHINRLRE-----EGRLD MJ0633 -------------TKFPFEEGWVIESLSDS--TIYPAYYTVAKYINQHN---------IK AF2421 -------------TRIPWDKEWLIESLSDS--TIYMAYYILAKYINAGL---------LK MTH1508 -------------TRLPWDERWIIEPLTDS--TIYMAYYTIAHRLREMD----------- Ta0777 -------------TRLPFDDRWVIESLSDS--TIYPAVYTNSIPLRSLY----------E TVN0761 -------------TKLPFDDRWVIESLSDS--TIYPAVYTTSIQMRKLY----------E APE1015 -------------TPLPWDREWVIESLSDS--TIYMAYYTIAKYTQHPEK-----YG-VE YLR382c K----------G-NPLSTIDEFVNVACPSC--GSPAKRETDTMDTFIDS----------- aq_1770 ------------------------------------------------------------ YPL160w -------------TRLPWDEKYLVESLSDS--TIYQSFYTIAHLLFKDYYGNEIGPLGIS leuS -SWYYARYTCPQY--------------------KEGMLDSEAANYWLP------------ ZleuS -SWYYARYTCPEY--------------------KEGMLDSEAANYWLP------------ VC0956 -SWYYARYCSPQA--------------------DD-ILDPEKANYWLP------------ HI0921 -SWYYARYTCPQY--------------------QNGMLDAEEANYWLP------------ PM1214 -SWYYARYTSPKF--------------------AEAMLDADEANYWLP------------ NMB1897 -SWYFFRYMSPKF--------------------SDGMVDPAAAKYWGA------------ NMA0559 -SWYFFRYMSPKF--------------------SDGMVDPAAAKYWGA------------ PA3987 -SWYFARYACPQF--------------------EGGMLDRKAADYWLP------------ XF2176 -SWYYARYTSPN---------------------AHEMLDKRAN-YWLP------------ BU444 -SWYYARYTCPNF--------------------NTGMIDSIASKYWLP------------ jhp1452 -SWYFLRYTTPKNQR------------------ENQAFDQNYLKYFMP------------ HP1547 -SWYFLRYTTPKNQR------------------ENQAFDQNYLKYFMP------------ Cj1091c -SWYFARFASDEKTW------------------QEKALDEKSVKYWMS------------ mll4077 -SWYFARFTAPW---------------------AYEPTDPRAANEWLP------------ CC3749 -SWYFARFADTQ---------------------AAEPVGKDAADHWLP------------ RP421 -SWYFTRYCNSN---------------------AVEMTDKKACNYWLP------------ VNG2223G -SWYFLRFASPAF--------------------DDAPFDTQRANDWLP------------ aq_351 -SWYFLRFCDPKN--------------------DREPFSREKVDYWMP------------ sll1074 -SWYFLRYADAQN--------------------TELPFDGEKVAHWLP------------ TM0168 -SWYFLRYVNPHL--------------------EDKPFEPDDVNYWLP------------ DR2174 -SWYMYRYLSPNY--------------------DGGPFDPSKA-GLLP------------ BS_leuS -CWYFLRYIDPHNP--------------------DQLASPEKLEKWLP------------ BH3281 -CWYYLRYIDPDNE--------------------RMIADPEKLKKWLP------------ L0352 -SWYYLRYIDPNNS--------------------EALADPELLKEWLP------------ SPy0173 -SWYYLRYIDPHNT--------------------EKLADEELLKQWLP------------ TP0586 -CWYYLRYMDPRNK--------------------TAFCAPEKERYWAP------------ BB0251 -CWYYLRYLDPKNS--------------------KEFANKKKIEYWMP------------ MG266 -CWYYLGYLMLIKNPN--------------FWPIDSKEAKKLFDQYLP------------ MPN384 -CWYYLGYLMLINNEN--------------FWPIDSREAKDLFERYLP------------ UU371 -SWYFLAYILKNEDGS--------------YTPLNSEEAKKRFAKWLP------------ CT209 -CWYYLRFCDAHNS--------------------AAPWAKEKEQYWMP------------ CPn0153 -CWYYLRFCDAHNS--------------------QLPWSKEKESYWMP------------ Rv0041 -SWYELRYTDPHNS--------------------ERFCAKENEAYWMGPRPAEHGPDDPG ML0032 -SWYELRYTDPHNS--------------------ERLCAKENEAYWMGPRPTEHGIDDPG PH0965 PEKLTPEFFDYIFLEEFSEDKEKELEKKTGIPAEIIHEMKEEFEYWYP------------ PAB1782 PEKLTPEFFDYIFLEEFSEEREKELEKKTGIPAEIIHEMKEEFEYWYP------------ MJ0633 PEQLTLELFDYVFLGKGDVDK---IAKETGIPKDIIEGMRKEFIYYYP------------ AF2421 AENMTPEFLDYVLLGKGEVGK---VAEASKLSVELIQQIRDDFEYWYP------------ MTH1508 AGEMDDEFFDAIFL-----DD---------SG--TFEDLREEFRYWYP------------ Ta0777 TGKLDDDAITRIFMN----GE---------PKNEDESEAKRQFEYWYP------------ TVN0761 NGKLDENAIERIFDG----GE---------VQNDEERTARNEFSYWYP------------ APE1015 PEMLTPEVFDYVFLGAGDPGE---VSRRSGIPQGLLEEMRREFLYWYP------------ YLR382c -SWYYFRFLDPKN--------------------TSKPFDREIASKNMP------------ aq_1770 ------------------------------------------------------------ YPL160w ADQMTDEVFDYIFQHQDDVKN-------TNIPLPALQKLRREFEYFYP------------ leuS -VDIYIGGIEHAIMHLLYFRFFHKLMRDA----GMVNSDEPAKQLLCQGMVLADAFYYVG ZleuS -VDIYIGGIEHAIMHLLYFRFFHKLMRDA----GMVNSDEPAKQLLCQGMVLADAFYYVG VC0956 -VDQYIGGIEHACMHLLYSRFFHKLLRDA----GYVKSDEPFKKLLCQGMVLADAFYYTN HI0921 -VDQYIGGIEHATMHLLYFRFFHKLLRDA----GFVTSEEPADKLLCQGMVLADAFYYTS PM1214 -VDQYIGGIEHATMHLLYFRFFHKLLRDA----GFVTSDEPADKLLCQGMVLADAFYYTS NMB1897 -VDQYIGGIEHAILHLLYARFFTKLMRDE----GLVNVDEPFERLLTQGMVVCETYYREN NMA0559 -VDQYIGGIEHAILHLLYARFFTKLMRDE----GLVNVDEPFERLLTQGMVVCETYYREN PA3987 -VDQYIGGIEHAILHLLYARFFHKLMRDE----GLVGSDEPFKNLLTQGMVVADTYYRTT XF2176 -VDQYIGGIEHAILHLMYFRFYHKLMRDA----RLVDSDEPAINLLTQGMVIAETFYRKN BU444 -VDQYIGGIEHAIMHLMYFRFYHKLLRDF----KLVDFDEPVKNLLCQGMVLSEAFYKID jhp1452 -VDTYIGGIEHAILHLLYARFFTKALRDL----GYLHLDEPFKQLITQGMVLKDG----- HP1547 -VDTYIGGIEHAILHLLYARFFTKALRDL----GYLHLDEPFKQLITQGMVLKNG----- Cj1091c -VDQYIGGIEHAILHLLYARFFQKALRDL----GYLTQNEPFDRLLTQGMVLKDG----- mll4077 -VDQYIGGIEHAILHLLYSRFFTRAMRAT----GHVDLAEPFKGLFTQGMVVHETYRVGG CC3749 -VDQYIGGVEHAILHLLYARFITRALKDE----GLLSVEEPFAGLFTQGMVTHEAYKN-- RP421 -VDKYIGGIEHAVMHLLYARFFTKLMNEH----NYVSIREPFKGLFTQGMVLHATYKD-- VNG2223G -VDEYVGGDEHAVMHLLYSRFVTKAFADL----DMLEHREPFAGLTTQGMVLGED----- aq_351 -VDVYIGGIEHAVLHLLYARFFQKFLKDL----GLVRDDEPFEKLITQGMVLKKW----- sll1074 -VDQYVGGIEHAILHLLYSRFFTKVLADR----QLIPVKEPFQKLLTQGMVQGITYKN-- TM0168 -VDQYIGGVEHAVLHLLYSRFVTKVLHDL----GYLNFDEPFTNLFTQGMIY-------- DR2174 -VDLYTGGIEHAILHLLYSRFWTKVMRDM----GLTTQSEPFARLRNQGMVLGED----- BS_leuS -VDMYIGGAEHAVLHLLYARFWHKFLYDI----GVVPTKEPFQKLYNQGMILG------- BH3281 -VDIYIGGAEHAVLHLLYARFWHKVLYDL----GVVPTKEPFQKLYNQGMILG------- L0352 -VDIYVGGAEHAVLHLLYARFWHKVLYDL----GVVPTKEPFQKLFNQGMILGTSYRD-- SPy0173 -VDIYVGGAEHAVLHLLYARFWHKVLYDL----GVVPTKEPFQKLFNQGMILGTSYRD-- TP0586 -VALYVGGAEHAVLHLLYARFWHKVLYDL----GLVSTKEPFARLVNQGMITSYAYRR-- BB0251 -VDLYIGGAEHTVLHLLYSRFWHKVLYDL----GYVNTKEPFKKLINQGIITSFSYQK-- MG266 -VDLYVGGAEHAVLHLLYARFWHKFLFDK----KLVSTKEPFQKLINQGMVLG------- MPN384 -VDLYVGGAEHAVLHLLYARFWHQFLYQK----GIVTTKEPFKKLINQGMVLG------- UU371 -VDVYIGGQEHAVLHLLYSRFWHRFLYDI----GVVPTKEPFYKVINQGMILG------- CT209 -VDLYIGGAEHAVLHLLYARFWHQVFYEA----GIVSTPEPFKKLVNQGLVLATSYRI-- CPn0153 -VDLYIGGAEHAVLHLLYSRFWHRVFYDA----GLVSTPEPFKKLINQGLVLASSYRI-- Rv0041 GVDLYVGGAEHAVLHLLYSRFWHKVLYDL----GHVSSREPYRRLVNQGYIQAYAYTD-- ML0032 GVDLYVGGAEHAVLHLLYARFWHKVLYDL----GHVSSREPYRRLINQGYIQAFAYTD-- PH0965 -LDWRCSGKDLIPNHLTFFIFNHVAIFR--------EEHWPKGIAVNGFGTLEGQ----- PAB1782 -LDWRCSGKDLIPNHLTFFIFNHVAIFR--------EEHWPKGIAVNGFGTLEGQ----- MJ0633 -VDWRCSAKDLIPNHLTFYIFNHVAIFP--------EEFWPRGIVVNGYVTIEGK----- AF2421 -VDLRSSGKDLVANHLLFYLFHHVAIFP--------PDKWPRAIAVNGYVSLEGK----- MTH1508 -LDWRLSAKDLIGNHLTFHIFHHSAIFP--------ESGWPRGAVVFGMGLLEGN----- Ta0777 -VDIRLTAIPHISNHLSFYVLNHAAIFP--------KEKWPAGLIISGLVVSNGA----- TVN0761 -VDIRLTAVPHISNHLSFYVMNHAAIFP--------PEKWPSGLIISGLVVSNGA----- APE1015 -LDMRISGKDLIPNHLVFFIFHHTAIFP--------RELWPRAIGVNGWVLVAG------ YLR382c -VDIYIGGVEHAILHLLYSRFIAKFLGSINAWSDPAGIFEPFKKLVTQGMVQGKTYVDP- aq_1770 -MKIKDFLQENKISVGDNAIFLLEKLGIK---------DENLIKFLEREIGES------- YPL160w -LDVSISGKDLIPNHLTFFIYTHVALFP--------KKFWPKGIRANGHLMLNNS----- : : leuS ENGERNWVSPVDAIVERDEKGRIVKAKDA-AGHELVYTGMSKMSKSKNNGIDPQVMVERY ZleuS ENGERNWVSPVDAIVERDEKGRIVKAKDA-AGHELVYTGMSKMSKSKNNGIDPQVMVERY VC0956 DKGGKEWVSPTEVKVERDGKGRIVSAVDA-TGRQVEHSGMIKMSKSKNNGIDPQEMVDKY HI0921 PTNERIWVSPTQVTLERDEKGRIIKATDP-EGRELVHSGMTKMSKSKNNGIDPQEMVEKY PM1214 PTNERIWVSPTEVTLERDEKGRILKAFDK-EGRELVHSGMTKMSKSKNNGIDPQEMVEKY NMB1897 DKGGKDWINPADVELTFDDKGRPISAVLKADGLPVVISGTEKMSKSKNNGVDPQELINAY NMA0559 DKGGKDWINPADVELTFDDKGRPVSAVLKVDGLPVVISGTEKMSKSKNNGVDPQELINAY PA3987 ANGGKDWFNPADVEVERDAKAKVVGARLKSDGQPVEIGGTEKMSKSKNNGVDPQSMIDQY XF2176 PDGSKDWINPADVNVECDERGRITGATLISDGQPVLIGATEKMSKSKNNGVDPQIMVTKY BU444 SNSQRKWFNSSSVLIKRNTKGEIIESHTQ-KGEKLIYAGMIKMSKSKNNGIEPELIIQRY jhp1452 -------------------------------------A---KMSKSKGNVVSPKEILKKY HP1547 -------------------------------------A---KMSKSKGNVVSPKEILKKY Cj1091c -------------------------------------A---KMSKSKGNVVDPDEIIEKY mll4077 ASNNGRWLSPAEVRIEDAEGKR--RAIEIATGEEAAIGSLEKMSKSKKNTVSPEDITDGY CC3749 --EAGEWVEPSDVVITTEGSTR--TAKHAKTGAPIIIGDIEKMSKSKKNVVAPEDIFEAY RP421 --ENNNWLYPAEVVKKGNE------FFHKENNTRVVQGRIEKMSKSKKNIIDLETIREQY VNG2223G -------------------------G--------------TKMSKSKDNGVAPERIVDEY aq_351 -------------------------V--------------SVKKLLDYLGLSEEDEVEEL sll1074 --PTTGKYVPAKDLQTGQQVIDPKDPKDPDSGEPLQVF-YEKMSKSKFNGVDPQEVLAKY TM0168 --------------------------KDG-----------AKMSKSKGNVVSPDEMIEKY DR2174 ---------------------------------------GEKMSKSRGNVVDPDDLVREY BS_leuS --------------ENNE-----------------------KMSKSKGNVVNPDEIVASH BH3281 --------------ENNE-----------------------KMSKSKGNVVNPDDIIDSH L0352 ---HRGALVATDKVEKRDG-----GFYHMETG-EALEQAPAKMSKSLKNVVNPDDVVEHY SPy0173 ---SRGALVATDKVEKRDG-----SFFHVETG-EELEQAPAKMSKSLKNVVNPDDVVEQY TP0586 ---KNGALVPHDEVHTNAQG----TYVHARTG-EKLECVVAKMSKALKNVVNPDDMIAAY BB0251 ---ENGVLIPNDQVIEKDN-----KFFDKKDN-KEVTQVIAKMSKSLKNVINPDDIIKEF MG266 ---------------PDGK----------------------KMSKSKGNTINPTPLVDSH MPN384 ---------------PDGK----------------------KMSKSKGNTINPTPLIDSH UU371 ---------------ENNE----------------------KMSKSKGNVINPDDIIASH CT209 ---PGKGYIYPEIAKEENG------KWVAPSG-EELDVRQEKMSKSKLNGVDPQILIDEF CPn0153 ---PGKGYVSIEDVREENG------TWISTCG-EIVEVRQEKMSKSKLNGVDPQVLIEEY Rv0041 ---ARGSYVPAEQVIERGDR----FVYPGPDGEVEVFQEFGKIGKSLKNSVSPDEICDAY ML0032 ---AHGSYVPANQVFQRGDG----FFCPGPDGEIEVFQEFGKIGKSLKNSVSPDEICDEY PH0965 -----------------------------------------KMSKSKGNVLNFIDAIEEN PAB1782 -----------------------------------------KMSKSKGNVLNFIDAIEEN MJ0633 -----------------------------------------KLSKSKGPVLPVLEVAEKF AF2421 -----------------------------------------KMSKSKGPLLTMKRAVQQY MTH1508 -----------------------------------------KMSSSKGNVILLRDAIEKH Ta0777 -----------------------------------------KISKSKGNVVSLLEIAKKY TVN0761 -----------------------------------------KISKSKGNVVSLLEITKKY APE1015 ----------------------------------------EKMSKSKGNFILLRQALDWW YLR382c --DSGKFLKPDELTFVNDSPDG--NTVIIKSNGKVPVVSYEKMSKSKYNGADPNECILRH aq_1770 ----------------------------------------AKMSKSKANVVDPEEAVEKY YPL160w -----------------------------------------KMSKSTGNFMTLEQTVEKF leuS GADTVRLFMMFASPAD--MTLEWQESGVEGANRFLKRVWKLVYEHTAKG--------DVA ZleuS GADTVRLFMMFASPAD--MTLEWQESGVEGANRFLKRVWKLVYEHTAKG--------DVA VC0956 GADTVRLFMMFASPAD--MTLEWQESGVEGANRFLRRVWKLVREHTELG--------QAP HI0921 GADTVRLFMMFASPAE--MTLEWQESGVEGAKRFLGRVWNLVYQYQQNP--------AKT PM1214 GADTVRLFMMFASPAE--MTLEWQESGVEGAKRFLGRLWNLVFEYNKHP--------AET NMB1897 GADTARLFMMFAAPPE--QSLEWSDSGVEGAHRFLRRLWRTVYEYLKQGEAVK---AFAG NMA0559 GADTARLFMMFAAPPE--QSLEWSDSGVEGAHRFLRRLWRTVYEYLKQGEAVN---AFAG PA3987 GADTCRLFMMFASPPD--MSLEWSDAGVEGANRFLRRVWRLAHAHVSAG--------LPG XF2176 GADTVRLFSMFAAPPE--QSLEWNEAGVEGMARFLRRLWTQVHHHAAHG--------PAT BU444 GADTIRLFIMFSAPVE--SDLEWKESGLKGIYRFLKKLWMLIFNYIDIKN-------THK jhp1452 GADAVRLFILFAAPPA--KELEWNDNALEGAHRFIKRLYDKANAITPTT-------SKPE HP1547 GADAARLFILFAAPPA--KELEWNDSALEGAHRFIKRLYDKANAINPTT-------SKPE Cj1091c GADTARLFILFAAPPA--KELEWNDDAVEGAYRFICKLYDRAQNVK-KG-------ELVE mll4077 GADTARWLMLSDSPPE--GDVEWTDDGAAGAHRFMQRIWRLVSTAAETL--------AGV CC3749 GVDSARLFVMSDSPPE--RDVQWTNSGVEGSWRFTHRLWNEFD----SQ--------PAG RP421 SADAIRLFVLSDSPPE--KDLEWSASGIEGCSRFINKLENMFE--------------AIF VNG2223G GADTARLFTLRAARPS--KAFPWSEEGVRSSHTFLERLLSMARAVN------------AD aq_351 KKRLEELGARRA------------------------------------------------ sll1074 GADTARMFILFKAPPE--KDLEWDDADVEGQFRFLNRVWRLVTDYIGDPAGIRFAVRPET TM0168 GADTLRMYILFMAPPE--KDAEWSDAGIEGVHRFVKRLWN--TFYTVLPFVK--EENTEN DR2174 GADTVRAFLMFIAPWE--LGGPWDPQGINGPSKWLSRVWNVFF---------------EE BS_leuS GADTLRLYEMFMGPLD--ASIAWSESGLDGARRFLDRVWRLFIED-SGE-------LNGK BH3281 GADTLRLYEMFMGPLD--ASIAWSTTGLDGARRFLDRVWRLLVDENTEE-------KSSK L0352 GADTLRVYEMFMGPLD--ASIPWSEEGLEGARKFLDRAVRMIENS------------E-I SPy0173 GADTLRVYEMFMGPLD--ASIAWSEEGLEGSRKFLDRVYRLITTK------------E-I TP0586 GADACRVYEMFMGPLE--ASKPWNTQGLVGVFRFLEKIWVLAGRVAAANGI-----PQDS BB0251 GADSMRIYEMFMGPLT--DSKPWNTKGIIGVFRFLNKIWNLREKE--------------L MG266 GADALRLYLMFMGPIS--ASLTWNDEGLNGMRRWLDRVYNFFFNH--------------A MPN384 GADALRLYLMFMGPIS--AALTWLDDGLNGMRRWLDRVHNFFHKE--------------N UU371 GADTLRIYEMFMGPLT--ASLPWNPDGLDAMRKWLDRVYRLYHNLS-----------ELE CT209 GADAVRMYAMFSGPLD--KNKLWSNQGVAGCRRFLNRFYEMVSSD--------------R CPn0153 GADALRMYAMFSGPLD--KNKTWSNEGVGGCRRFLNRFYDLVTSS--------------E Rv0041 GADTLRVYEMSMGPLE--ASRPWATKDVVGAYRFLQRVWRLVVDEHTG---------ETR ML0032 GADTLRVYEMSMGPLE--ASRPWATKDVVGAYRFLQRVWRLVVDERTG---------ETR PH0965 GADVVRLYIMSLAEHD--SDFDWRRKEVGKLRKQIERFYELIS--------------QFA PAB1782 GADVVRLYIMSLAEHD--SDFDWRRKEVGKLRRQLERFYELIS--------------QFA MJ0633 GADVGRFYITTCAELP--QDADIKFKEMENTKKVLERLYLFAK--------------EIA AF2421 GADVTRLYILHAAEYD--SDADWKSREVEGLANHLRRFYNLVK--------------ENY MTH1508 GADVVRLFLMSSAEPW--QDFDWRESEVIGTRRRIEWFREFGERVSGILDG------RPV Ta0777 SADIYRLYVAVQADIS--STMDWNETDLASITRRFNEFKDLMA--------------G-F TVN0761 SADIYRLYVAVQADVS--STMDWNENDLSNIVRRFNEFKTIMD--------------S-F APE1015 GADATRWAEVLAGADSGLDDANFEPSVADSAVSLLSQWLDFVRENYG----------RPA YLR382c GPDATRAHILFQSPIA--DALNWDESKIVGIERWLQKVLHLTKNILSLEKD---LAISKD aq_1770 GADTVRLYILFAAPPE--QDFEWTDEGIQGAYRFLQRYWNFVNKHLEKIKN-----LTYT YPL160w GADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITK------------ESN . leuS ALNVDALT------ENQKALRRDVHKTIAKVTDDIGRRQ---TFNTAIAAIMELMNKLAK ZleuS ALNVDALT------EDQKALRRDVHKTIAKVTDDIGRRQ---TFNTAIAAIMELMNKLAK VC0956 ALDASALN------ADQKALRRDVHKTIAKVTDDVARRQ---TFNTAIAAIMELMNKLTK HI0921 SLDLTALS------AEQKVLRREVHKTIAKVSDDIGRRQ---TFNTAIAAVMELMNKLTK PM1214 TVEPTALS------SAQKALRRDVHKTIAKVSDDIGRRQ---TFNTAIAAIMELMNKLTK NMB1897 SQD--GLS------KELKDLRHKLHATTAKVSDDYGRRQ---QFNTAIAAVMELLNQYDK NMA0559 SQD--GLS------KELKDLRHKLHSTIAKVSDDYGRRQ---QFNTAIAAVMELLNQYDK PA3987 ALDVAALS------DAQKQVRRAIHLAIRQASQDVGQHH---KFNTAIAAVMTLMNVLEK XF2176 ALDITALD------TAQKAMRCKTHNTIARVEDDYGRRR---SFNTAIAAVMELSNTLAR BU444 KINFDFLN------HQQSELRYQLHKTIAKVSDDIGRRQ---TFNTAISEIMKLVNQLSK jhp1452 FKEV-GLN------EAQKLARKKVYEALKKSHEIFNKAESAYAFNTLIASCMEALNALNA HP1547 FKEV-SLN------EAQKLGRKKVYEALKKSHEIFNKAESAYSFNTLIASCMEALNALSA Cj1091c LKQE-NLN------KEEKYARLKVYEALKKSFEVYHQS---FAFNTLIAACMEALNALAL mll4077 KPAAADSG------EAG-AVRKATHKILKAVGEDIEKLG----FNRAIARIYELANVLTT CC3749 DFAHDDSD------EAALALRKAAHKLIGFVTDSIEGFR----FNSGVARLYEFLNALKA RP421 SLKDDMKS------EINKDLNRLIHLTIKHVADDIKTFS----LNRAIARMRTLTNAIYY VNG2223G ATADGDLD------PAAEYVARETAATVQAATTHFDDME----FNRAVQAVDELVSLLVR aq_351 ------------------------------------------------------------ sll1074 LVTNEPLT------KAEKDLRRAIHGAIKEVAEDLNDDY---QFNTAISEMMKLSNALIA TM0168 LVLKN---------STEKELRRKLHSIIKKITEDIEGGF---KFNTAISGLMELVNHLSQ DR2174 KVSGPEEK------MQGADVRFAVHSALKKVNDDFERMS----FNTIISTLMELTNALVK BS_leuS IVEGAG-E----------TLERVYHETVMKVTDHYEGLR----FNTGISQLMVFINEAYK BH3281 IVNGEGSP----------ELKRAYHQTVKKVTEDFEELR----FNVGISQLMVYVNEAYK L0352 KAENNG------------ELDKVYNETVKNVTERLDLMY----FNTAISQLMIFVNAVNK SPy0173 TEENSG------------ALDKVYNETVKAVTEQVDQMK----FNTAIAQLMVFVNAANK TP0586 RAEPPGDLHAQKKSCSMYALETLLHRTIQKVTDDTSALS----FNTAISQMMIFVNEATR BB0251 SKENPP-----R------EIISELHKVIKKVTEDTEKLN----FNTAISAMMIFINELLK MG266 VVTDQ----------VSQETIFAYNLFLKNSYCHLDKHE----LNLVISEMMIFLNFLYK MPN384 IIKET----------VDQETVYGYNLFLKRSFEHLEKQE----LNLVISQMMIFLNLLYK UU371 VVEDLN---K-----LNEEIIIAYHTLIKNYTKAINEQA----FNIAISEMMVFVNVLYK CT209 VKEDNN-----------FEGLSLAHKLVQRVTDAIEKLS----LNTIPSSFMEFINDFVK CPn0153 VQDIED-----------RDGLVLAHKLVFRITEHIEKMS----LNTIPSSFMEFLNDFSK Rv0041 VADGV---------ELDIDTLRALHRTIVGVSEDFAALR----NNTATAKLIEYTNHLTK ML0032 VVDTAG--------ELDTYTLRTLHRTIAGVSQDYAALR----NNTATAKLIEYTNHLTK PH0965 EYEVKGNV------ELKDIDRWMLHRLNKAIKETTNALEEFRTRTAVQWAFYSIMNDLRW PAB1782 EYEAKENV------ELKTIDKWLLHRLNKAIEGTTKALEEFRTRTAVQWAFYSIMNDLRW MJ0633 ERRGETGE------EFSYIDKWLLSRLYKAVKQYDEYMENFELRKAG-ILLYQLLDDLKW AF2421 LKEVG---------ELTTLDRWLVSRMQRAIKEVREAMDNLQTRRAVNAAFFELMNDVRW MTH1508 LSEVTPAE------PESFIGRWMMGQLNQRIREATRALESFQTRKAVQEALYLLKKDVDH Ta0777 KQDTS---------DLTFEEAWFVARFSVRLRQFMESMDRYQIRDAYINIFYGVLNDLRY TVN0761 KPDTS---------ELNFEETWFVSRFAERLKQFMDQMDGFQIRDAYINIFYGTLNDLKY APE1015 RREER---------WVDRWFESRLNSTIARVTRLMEEAN---FKTALVEAWYKLQESYRW YLR382c YKTPTDLN------DAEVKFHNDFQRFLKSITESFEVNLS---LNTVISDYMKLTNILES aq_1770 VEELRNVQG------KAKEVRREIHQTIADYRRDFEERY---QFNTAIAKIMKLLNTLQD YPL160w LRTGEIT---------DFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDY leuS APT------DGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGD-IDNAPWPVAD ZleuS APT------DGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEGD-IDNAPWPVAD VC0956 APM------TEAQDRAILDEALKAITLMLYPITPHICFEMWVAL-GQSN-IDTASWPTYD HI0921 ASL------DSEQDRAVMAEALSAVVRMLYPITPHICFELWQALGNESA-IDTAEWVKAD PM1214 APL------VEVQDRAIMAEALSAVVRMLYPITPHICFQLWKDLGNTEA-IDFAPWVEAD NMB1897 TDT------GGEQGRAVAQEVLETAVRLLWPIVPHICETLWSELNGAK--LWEAGWPTVD NMA0559 TDT------GSEQGRTVAQEVLEAAVRLLWPIVPHICETLWSELNGAK--LWEAGWPAVD PA3987 APN------QDAQDRALIQEGLETVVLLLAPITPHICHVLWGQLGHAEA-VIDARWPSVD XF2176 FDD------TTTQSHAVRQEALETMVLLLNPITPHTSHALWQTLGHPETLLEDLPFPKID BU444 API------KEEQDKSIMRESLICIIKMLYPFTPHFCFFVWNYFNNHSS-IDNEKWPIFQ jhp1452 Q-----------SDEQILCEGYFVLLQILEPMIPHTAWELSERLFKRE----NFKPIEVD HP1547 Q-----------NNERILCEGYFVLLQILEPIIPHTAWELSERLFKRE----NFKPIAID Cj1091c C-----------KNEALEQEAFYIILNILEPIIPHVCFELSEELFKCK----NFKKLELK mll4077 PLNQVAEGKADPALQGACREAVEILVHLIAPVMPHLAEECWETLGGTDL-VAERPWPAFD CC3749 AP---AEG-ASQAVLAARAEALNILARLVAPFTPHLAEEAWARMGGEGM-VVDAPWPKAD RP421 EIS--KD----RIDVRTIKYGFNVLVQLLNPFIPHITEEIWQKLGNKER-LYKSVFAEFD VNG2223G YRD------RDDAAPAVVARGVTAAVKLLAPIAPHVAEECWTALGGDGF-VAEAAWPTPD aq_351 ------------------------------------------------------------ sll1074 ATDLIS--------FPVYQEGIETLLLLLAPFAPHLTEELWHRLGRTDS-IHQQAWLQVD TM0168 YLNSVPQ---EEWNRKLLREIVEKLTLALSPFAPHLAEEFWHDLGNDSL-VVQQSWPSYD DR2174 AKR------SPVFGTPVWEEALDIFNRMLAPVVPHIAEEIWHERGQKGS-VHTAQWPQVD BS_leuS ATE-------------LPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGT-IAYEAWPVYD BH3281 QEE-------------LPLDQAEGFVKLLSPVAPHLAEELWSKLGHEGT-IAYEPWPTYD L0352 AKA-------------LPLEYANGFVQLLAPFAPHIAEELWVKLGNEAG-ISYVAWPTFD SPy0173 EDK-------------LFSDYAKGFVQLIAPFAPHLGEELWQALTASGESISYVPWPSYD TP0586 VARR----------MPLPSKMWEMFVKILSPYAPHLAEELWEMCGHTHT-IAYEPWPQVD BB0251 YEKN-------------YLNIFKPFIIILSPYAPHLAEELWEYIGELPSLFKNSKWPKFD MG266 TKK-------------ISLNYAKGFLTVLSFFAPFLAEELNEKCGLEPF-VVKQAISLVD MPN384 TKQ-------------LTLAYAKGFLTVLSFFAPYLAEELNAKLGMEPF-IVHAQLPNVD UU371 NKV-------------INYELLDNFLILLSCYAPHLAEELYS-LNHSES-VCLQKMPIYD CT209 LAV-------------YPKSAVEMAVRALAPIAPHISEELWVLLGNSPG-VQKSGWPSVL CPn0153 LPV-------------YSKRALSMAVRVLEPIAPHISEELWVILGNPPG-IDQAAWPQID Rv0041 KHR-----------DAVPRAAVEPLVQMLAPLAPHIAEELWLRLGNTTS-LAHGPFPKAD ML0032 EHR-----------GSVPRVAVEPLVLMLAPLAPHLAEELWLRLGHTTS-LANGPFPQAD PH0965 YLRRTE-GRDDEAKRYVLRTLADVWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVE PAB1782 YMRRTE-GRDDEAKRFVLRKLADIWVRLMAPFTPHICEELWEKLGGEGFVSLAKWPEPVD MJ0633 YRRR---GGNN--IR-VLEEFLEVIIKLMMPFTPHLCEEMWEILGKEGFVSLAKFPEVKE AF2421 YLRR---GGEN------LAIILDDWIKLLAPFAPHICEELWH-LKHDSYVSLESYPEYDE MTH1508 YLKRVE-GRVDDEVKSVLANVLHAWIRLMAPFIPYTAEEMWERYGGEGFVAEAPWPDFSD Ta0777 LSSR---GGDV--NR-ALTPVIADWLRALMPVIPHHAEEYWHSYVSDTYVSVDPFDENFQ TVN0761 AVNR---GASQ--NR-SLASIIADWLRALMPVISHHAEEYWHRYVSNTYVSINPFDDNFA APE1015 YLRR----SGGEPREDLLRRFIEVQTLLIAPFAPHTAEEAWEAMGREGFASTASWPEPDE YLR382c ALK------KGEVRNEMIVQNLQKLVTVIYPAVPSISEEAAEMINSQME-WNQYRWPEVE aq_1770 FSP------QTEQDYKVLREGIETITLLLSPITPHIAEEVWEMLGNEGF-IINQPIPEPD YPL160w YREAS-----GVMHKDLIARYIETQALLLAPIAPHFAEYIYREVLGNQTSVQNAKFPRAS leuS EKAMVED-------------STLVVVQVNGKV---RAKITVP------------------ ZleuS EKAMVED-------------STLVVVQVNGKV---RAKITVP------------------ VC0956 EAALVED-------------EKLIVLQVNGKL---RGKLTVA------------------ HI0921 EAAMVED-------------EKLIVVQVNGKV---RGKVTVA------------------ PM1214 AAAMVDD-------------EKLVVVQVNGKV---RAKVTVP------------------ NMB1897 EAALVKS-------------EIEVMVQVNGKL---RGKITVA------------------ NMA0559 EAALVKS-------------EIEVMVQVNGKL---RGKITVA------------------ PA3987 ESALVQD-------------TLQLVVQVNGKL---RGHIDVA------------------ XF2176 TTALVRE-------------TTTLAVQVNGKL---RGTIEVA------------------ BU444 KDILSKK-------------YSTIVAQINGKK---RCATKIS------------------ jhp1452 ESALIED-------------FMTLGLTINGKR---RAELKVN------------------ HP1547 EDALMED-------------FMTLGLTINGKR---RAELKVN------------------ Cj1091c EEVFVKD-------------TLNLAVSINGKK---RAEFEIS------------------ mll4077 PALVVDN-------------EVTYPVQVNGKK---RGDLTIA------------------ CC3749 PALAADD-------------ERVLPIQINGKR---RGEIKVK------------------ RP421 ESILELS-------------TYIMAVQVNGKL---RDTYEFD------------------ VNG2223G RDVSDHDR------------ATSLIEQTREDV---RDIVDTAGIENPTGVDVVTAP--EW aq_351 ------------------------------------------------------------ sll1074 PTALVLD-------------EITLVIQVLGKT---RGTITVP------------------ TM0168 PKALEVE-------------EVEIAIQINGKV---RDKVVVP------------------ DR2174 EAAAVRD-------------TVTIGVQVSGKV---RGEVSIS------------------ BS_leuS ETKLVDD-------------EVEIVVQLNGKV---KAKLQVPADAT-------------- BH3281 EAFLVED-------------EVEIVVQHNGKV---RAKVVVAKDAT-------------- L0352 ESKLIES-------------EVEIVVQINGKL---KAKIKIAKDLA-------------- SPy0173 ESKLVEN-------------DVEIVVQIKGKV---KAKLVVAKDLS-------------- TP0586 PARVAPH-------------VCSVVVQVNGKV---RDTFSVAPNAP-------------- BB0251 ESLIIKG-------------KKEIVLQINGKI---KDKILLNKETG-------------- MG266 YQLFETA-------------KTKVILSINGKF---KAAKEFTKGS--------------- MPN384 NSVLETD-------------KVKIILSVNGRF---KGTKEFAKGV--------------- UU371 EQKIIAQ-------------NITIPIQINGKL---KHTINVLRDTN-------------- CT209 PEYLEGQ-------------TVTIVVQVNGKL---RARLDIMKDAS-------------- CPn0153 ESYLVAQ-------------TVTFVVQVNGKL---RGRLEVAKEAP-------------- Rv0041 AAYLVDE-------------TVEYPVQVNGKV---RGRVVVAADTD-------------- ML0032 PAYLVDD-------------TVEYPVQVNGKI---RGRIVVAADAD-------------- PH0965 EWWNETIEAEEEFIR-SVMEDIKEIIEVAKIENAKRAYIYTAEDWKWKVAEVVSEK--RD PAB1782 EWWNEEVEVEEDFIK-SLIEDIKEIIEVAKIESPKRAYIYTAPEWKWKVYEVVAEK--RE MJ0633 EFINDEIEKGEEYLK-AVMEDIKEIINVAKVQ-PKRIYLYTADDWKYEILKIIKENEGKT AF2421 TRVDEEAERIEEYLR-NLVEDIQEIKKFVSDA--KEVYIAPAEDWKVKAAKVVAES--GD MTH1508 DAESRDVQVAEEMVQ-NTVRDIQEIMKILGST-PERVHIYTSPKWKWDVLRVAAEVGKLD Ta0777 DRYERTVRRFGMTCD-QMYSAMDYVEKVLQDV--KNIMQVTGIEPK--SVEITVAN--AD TVN0761 EKYERLAKVYGLSTS-EFYQVMDYVEHIIQDI--NNIISVTGIEPK--SVEITVAN--ED APE1015 SKISPEVEAAEETVQ-AVLEDAREVLSLIGGAD--TLVVTVAAEWKYRAVEAVRRARERG YLR382c RTTESKF--------------KKFQIVVNGRV---KFMYTADKN---------------- aq_1770 PEALKVE-------------EIEIPVQVNGKL---RARVKVP------------------ YPL160w KPVDKGVLAALDYLRNLQRSIREGEGQALKKKKGKSAEIDASKPVKLTLLISESFPEWQS leuS -------VDATEEQVRERAGQEHLVAKYLDGVT--------------------------- ZleuS -------VDATEEQVRERAGQEHLVAKYLDGVT--------------------------- VC0956 -------ADATQQQVEALGMQDENVQKFIDGLT--------------------------- HI0921 -------TDADEDTVKTIAFADENVKKFIDNQH--------------------------- PM1214 -------AEMSEDDIKQVALADSNVAKHLEGLN--------------------------- NMB1897 -------ADASKADLEAAALATEGAVKFMEGKP--------------------------- NMA0559 -------ADASKADLEAAALATEGAVKFMEGKP--------------------------- PA3987 -------ASASREDVEAAARANENVLRFTEGLS--------------------------- XF2176 -------TDAPREHIENNARTEPNTARFLEGLT--------------------------- BU444 -------DSLTKEEIFLYIQNQPIIKKYLEDVD--------------------------- jhp1452 -------INASKEEIIILAK--KELEKYLENAS--------------------------- HP1547 -------INASKEEIIVLAK--KELEKYLENAS--------------------------- Cj1091c -------SSASKEEILAFAK--ENTAKWLEGKS--------------------------- mll4077 -------RDADQGAVEKAVLALDFVQKALEGKA--------------------------- CC3749 -------AGAPDDEVTKIALADPNVMAHLEGLT--------------------------- RP421 -------VDISEDEVKQITVNLPKVQKFLAGKE--------------------------- VNG2223G MYDVLARAKAADGNVVGSVMSDQSLQQHGEDAADY--AKDLAAQAPAFPDVLGPDGERDA aq_351 ------------------------------------------------------------ sll1074 -------ASADKTQLEELARNSDLAQRYLEGKT--------------------------- TM0168 -------VDISEEDLKRIVLERERVKEYVDGKP--------------------------- DR2174 -------KTASQEEALSAARAIAEVQKHLEGKT--------------------------- BS_leuS -----------KEQLEQLAQADEKVKEQLEGKT--------------------------- BH3281 -----------KEQMEEAALANERVKESIDGKT--------------------------- L0352 -----------REELEKIG--RESVAEALEGKN--------------------------- SPy0173 -----------REELQEVALANEKVQAEIAGKD--------------------------- TP0586 -----------NEELEQKARETAGARKFLGTQQ--------------------------- BB0251 -----------EKELKEIAMENSKIKSNLLNKK--------------------------- MG266 -----------LEIDVLESFKQDKEINDILNQP--------------------------- MPN384 -----------DEQTVLKAFKTDPEFQALFDQP--------------------------- UU371 -----------AEELVNLALACEQVKQEIGDQP--------------------------- CT209 -----------KEEVLALAR--ESASKYLEGCE--------------------------- CPn0153 -----------KEEVLSLSR--SVVAKYLENAQ--------------------------- Rv0041 -----------EETLKAAVLTDEKVQAFLAGAT--------------------------- ML0032 -----------YDTLKTVALADDKVQQFLAGAT--------------------------- PH0965 FKSSMEELMKDSEIRKHGKEVAKIVQKLIKERTF---DVKRINEEKALREAKEFMEKELG PAB1782 FKSAMAELMKDEEIRKHGKEVAKLVQAIIKERAF---DVKRIDEEKVLRESKDFLEKELG MJ0633 IKELMPIIMKNPEFRKYGKEIPKLVNQLIKLN------AEIINEVEVLENAKEFLKKEVG AF2421 VGEAMKQLMQDEELRKLGKEVSNFVKKIFKDRK----KLMLVKEWEVLQQNLKFIENETG MTH1508 MGSIMGRVSAEG-IHDNMKEVAEFVRRIIRDLGKS--EVTVIDEYSVLMDASDYIESEVG Ta0777 VVRAAQEFLNNS-VSGQSKKYMQYLAKRRKDIM-----IYGFDEYDVLQRNQVYLSKQIG TVN0761 VIKASREFLSNS-VSERSKRYLQYLAKRRKDIV-----VYPFNEIDILRRNSSYISRQVK APE1015 ASMKEALREAFKVEGVDKREAARLVQQLSRAPEVLRRAAPRSVELEALRDAAQLLQEELG YLR382c ------FLKLGRDAVIETLMNLPEGRMYLMNKK--------------------------- aq_1770 -------ADADEETVKNIVLSDERVQKWVQGKE--------------------------- YPL160w QCVEIVRKLFSEQTLDDNKKVREHIEPKEMKRAMPFISLLKQRLANEKPEDVFERELQFS leuS ---------------------------------------------------VRKVIYVPG ZleuS ---------------------------------------------------VRKVIYVPG VC0956 ---------------------------------------------------VRKVIYVPG HI0921 ---------------------------------------------------IVKVIYVVG PM1214 ---------------------------------------------------IVKTIYVPG NMB1897 ---------------------------------------------------AKKIIVVPG NMA0559 ---------------------------------------------------AKKIIVVPG PA3987 ---------------------------------------------------IRKVIVVPG XF2176 ---------------------------------------------------VLKIIIVPG BU444 ---------------------------------------------------IKKIIYIPK jhp1452 ---------------------------------------------------VKKEIYVPN HP1547 ---------------------------------------------------VKKEIYVPN Cj1091c ---------------------------------------------------IVKEIYVEG mll4077 ---------------------------------------------------PRKVIIVPQ CC3749 ---------------------------------------------------VRKVIVVKD RP421 ---------------------------------------------------PRNIILVPR VNG2223G LGRAVWLLEA-------------------------------------EFDAPVRVLAAED aq_351 ------------------------------------------------------------ sll1074 ---------------------------------------------------IKKVIVVPG TM0168 ---------------------------------------------------IRKFIYVKG DR2174 ---------------------------------------------------VVKEIYVPG BS_leuS ---------------------------------------------------IRKIIAVPG BH3281 ---------------------------------------------------VRKVIVVPG L0352 ---------------------------------------------------VVKVIAVPN SPy0173 ---------------------------------------------------IIKVIAVPN TP0586 ---------------------------------------------------PKRVVIVPN BB0251 ---------------------------------------------------IVKIIVIKN MG266 ---------------------------------------------------IERVVYVQD MPN384 ---------------------------------------------------LARVVFVPN UU371 ---------------------------------------------------IKKQIVVVN CT209 ---------------------------------------------------VKKAIFVPA CPn0153 ---------------------------------------------------IRKEIYVPN Rv0041 ---------------------------------------------------PRKVIVVAG ML0032 ---------------------------------------------------PRKVIVVAG PH0965 IEIIIN--PT-------------------------------------EDKGGKKKQAMPL PAB1782 LEVIIN--PE-------------------------------------EDKGGKKRQAIPL MJ0633 VEDIII--NG-------------------------------------EDKANKKRVAIPF AF2421 LKVILD--TQ-------------------------------------RVPEEKRRQAVPG MTH1508 ARVVIHSKPD-------------------------------------YDPENKAVNAVPL Ta0777 CPVRIE--RG-------------------------------------DVINGK--IALPG TVN0761 ADVSIN--TG-------------------------------------DIINGK--IAVPG APE1015 VKVVVETE-E-------------------------------------DGGSPRRANALPG YLR382c ---------------------------------------------------IKKFVMKFN aq_1770 ---------------------------------------------------VKKFIYVKG YPL160w EIDTVKAAARNVKKAAQALKIAEFSAISFPYGAKTGKDIFTGEEVEIPPVTKIVENAVPG leuS KLLNLVVG--------------- ZleuS KLLNLVVG--------------- VC0956 KLLNIVAN--------------- HI0921 KLLNVVVKP-------------- PM1214 KLFSFVAK--------------- NMB1897 RLVNIVV---------------- NMA0559 RLVNIVV---------------- PA3987 KLVNIVAN--------------- XF2176 KIVNIVAR--------------- BU444 KIINFVT---------------- jhp1452 KLVNFVTA--------------- HP1547 KLVNFVIA--------------- Cj1091c KLVNLVIK--------------- mll4077 RIVNVVA---------------- CC3749 RIVNIVAN--------------- RP421 KIVNIIV---------------- VNG2223G AADSVANKAEPGRPAIHVDEADD aq_351 ----------------------- sll1074 KLVNFVIT--------------- TM0168 RIVNIVV---------------- DR2174 RIINIVAK--------------- BS_leuS KLVNIVAN--------------- BH3281 KLVNIVAN--------------- L0352 KLVNIVVK--------------- SPy0173 KLVNIVIK--------------- TP0586 KLVNFVL---------------- BB0251 KLVNIVIK--------------- MG266 RIINVLLKK-------------- MPN384 RIINVLLKSE------------- UU371 KIINFVI---------------- CT209 RLVNFVV---------------- CPn0153 KLVNFVL---------------- Rv0041 RLVNLVI---------------- ML0032 RLISLVI---------------- PH0965 KPAIFIE---------------- PAB1782 KPAVFIE---------------- MJ0633 KPAIYLE---------------- AF2421 KPAIYVA---------------- MTH1508 KPAIYLE---------------- Ta0777 KPVIYIS---------------- TVN0761 KPVIHIT---------------- APE1015 RPALYAEKRGG------------ YLR382c VISFLFHK--------------- aq_1770 KLVNVVVK--------------- YPL160w NPGVVFQNI--------------