CLUSTAL W (1.74) multiple sequence alignment rnd -----------------------------MNYQMITTDDALASLCEAVRAFPAIALDTEF Zrnd -----------------------------MNYQMITTXDALASLCEAVRAFPAIALDTEF VC1984 ---------------------MSNNCELSVNYQIISQVGDLQRVCLAARDADVVMLDTEF HI0390 --MSKWDSNIPFLFFSNKKITMIKECQNPPHFRVVTDNTALLEVCNLAQQKSAVALDTEF PM0706 ------------------MNSQQKEIKNKPHFQVITSDLALAEICYSAQQKAVIALDTEF mll8354 -------------------------------MHVITTQKELETVLAAFEKSDFVTVDTEF CC1704 -------------------------------MKLITTTAELAAFCNGLAGEPFVAVDTEF Rv2681 MCPEPSHAGAAESEGTESEPTPLLRPAGGIPDLCVTVGEIAAAAELLDRGRGPFAVDAER ML1040 -MREPADD---QPGGTEPDPTPLHYPAGGIPNLSVTPSEIAAAAERLDQGYGPFAVDTER mll3296 -----------------------------MADIRFHKHDLPDL---SHYNVGAVAIDTET CC3603 -----------------------------MANF-VHEGDLPDG---VFADAEIIAIDSET RP422 ------------------------------MNIKIYQNDLPS----NFKLEGDIAVDTET sll0320 -----------------------MPSADTLSQFEVFDYDLPEDVCQQLLACKEVAVDTET PA1294 --------------------------MTAPEIQWIRDDASLAQQCREWRTQPYLALDTEF XF0751 ------------------------------MPHWIQHPDTLAT--WWDRKPTRIGMDTEF RP462 -------------------------------MQIIDKQKTLEEFCNKLANHTSLSIDTEF YOR001w_2 ----------------------------------VDTSTELESMLEDLKNTKEIAVDLEH . . :* * rnd VRTRTYYPQLGLIQLFDGEH-LALIDPLG-ITDWSPLKAILRDPSITK----FLHAGSED Zrnd VRTRTYYPQLGLIQLFDGEH-LALIDPLG-ITDWSPLKAILRDPSITK----FLHAGSED VC1984 VRTRTFFPQLGLIQMFDGEN-LSLIDPTV-LDEMTPFVELLQDTSVLK----VLHACGED HI0390 MRVSTYFPKLGLIQLYDGEH-VSLIDPLA-ITDFSPFVALLANPKVLK----ILHSCSED PM0706 VRIKTLYPQLGLIQLYDGER-VSLIDPTT-IQDFSPFIALLANTAVLK----VLHACSED mll8354 IRETTFWPILCLIQMAAPGV-TALIDPLSPDINLAPFFRLMANEAVVK----VFHAARQD CC1704 MRETTYWPKLCLIQVASPTQ-EAVIDPLADNIDLEPLLVVMRDERILK----VFHAARQD Rv2681 ASGFRYSGRAYLIQIRRAEAGTVLIDPVS--HGGDPLTVLAPVAEVLSTNEWILHSADQD ML1040 ASGFRYSNRAYLIQIRRANAGTVLIDPVS--HGNDPLTALRPVAEVISKDEWILHSADQD mll3296 LGLNPHRDRLCLVQISPGDGSADVIQIAPGQKKAPNLVSLLRNRSVTK----LFHFGRFD CC3603 MGLRLRRDPLCVVQLSAGDGDAHVVRLSRPDYDCPNLKALLTNPKVLK----LFHFGRFD RP422 MGLNIHRDKLCLLQFSNGNGEAHLVHFINQDYTAPNLKMLLLDKTRCK----IFHFARFD sll0320 MGLNPHRDRLCLVQICDPEGNVTALRIAKGQEEAPNLTRLMEDPGITK----IFHFARFD PA1294 MRVDTFYPAAGLVQVGDGRQ-EWLIDPLL-IQDWSPFAELLEDERVVK----VLHACSED XF0751 IRERTFWPELALVQIAIEDE-ILLVDPLV-PGMTDALGLWLAAPNVIK----IMHSASED RP462 ERRYTYYAQLSIIQVKAEGY-CGIIDTLS-NLDLNIFNKLLIDNNITK----IFHAPRED YOR001w_2 HDYRSYYGIVCLMQISTRER-DYLVDTLKLRENLHILNEVFTNPSIVK----VFHGAFMD ::*. : : . .:* * rnd LEVFLNVFGELPQPLIDTQILAAFCGRP-MSWGFASMVEEYSGVTLDKSESRTDWL-ARP Zrnd LEVFLNVFGELPQPLIDTQILAAFCGRP-MSWGFASMVEEYSGVTLDKSESRTDWL-ARP VC1984 LEVFQNAFGCTPFPMVDTQIMAAFLGYG-LSTGFAALVQDQLQVELDKSESRTDWL-ARP HI0390 LLVFLQEFDQLPRPMIDTQIMARFLGLG-TSAGLAKLAQQYLNVEIDKGATRTNWI-KRP PM0706 LEVFQHSFNQLPTPMLDTQIMANFLGFP-NSTGLATLVQHYFQLEIDKGASRTDWL-ARP mll8354 IEIIVHLGDLVPHPVFDTQVAAMVCGFG-DSVSYDQLVQRITGARLDKSSRFTDWR-HRP CC1704 VEIFNNL-KAMPKPLFDTQVAGMAAGFG-EQIAYDALVRQMLRIEIDKSSRFTDWA-RRP Rv2681 LPCLAEV-GMRPPALYDTELAGRLAGF--DRVNLAAMVERLLGLGLTKGHGAADWS-KRP ML1040 LPCLAEV-GMRPPALYDTELAGRLAGF--DRVNLATMVQRLLGFELAKGHGAADWS-KRP mll3296 LAVLYNAFGVMPEPVFCTKIASRLTRTYTDRHGLKDICFELLGVGLSKAQQSSDWA-AET CC3603 IAMFELHLGVVTAPVYCTKIASKLARTYTDRHGLKDVTRELLGVELSKVQQSSDWG-APS RP422 LASIKKYLSIDLENIFCTKISSKLVRTYTDSHGLKDLCRELLNINISKQQQSSYWG-TDH sll0320 TAQLKHTFDIKTYPIFCTKIASKIARTYTSHHGLKTLVQELVGVELDKSSQCSDWGNAAN PA1294 LEVFLRLTGSLPVPLFDTQLAAAYLGMA-HSMGYSKLVKEVLDIDLPKDETRSDWL-QRP XF0751 LIAFKYACGVLPRPLFDTQIGAALTGLG-GGMGYQKLVATVTNVALEKGETRSDWM-HRP RP462 LEIFYNLFKTLPSNIFDIQIAASICGFG-QQLSYDNLCYKLIGITIDKTHQKSNWL-KRP YOR001w_2 IIWLQRDLGLYVVGLFDTYHASKAIGLP--RHSLAYLLENFANFKTSKKYQLADWR-IRP : : . : * : * rnd LTERQCEYAAADVWYLLPITAKLMVETEA---SGWLPAALDECRLMQMR----RQE--VV Zrnd LTERQCEYAAADVWYLLPITAKLMVETEA---SGWLPAALDECRLMQMR----RQE--VV VC1984 LSDKQLEYAAADVFYLLPMYEKLVEQVTQ---AGWWDAALQESELQVAK----RTK--VS HI0390 LSDIQLQYAAGDVWYLLPLYHILEKELAK---TPWEQAVRDDCELVLAKTH--KLQ--ER PM0706 LSDNQLIYAAADVWYLLPLYQRMQEALAQ---TRWQEAAQQDCEALLLK----REQ--HK mll8354 LSDKQLDYALADVTHLIEVYQHLSAELAR---ENRAHWLNEEMDVLTSR----ETY--DP CC1704 LTDAQLSYALADVTHLAKLFPILRERLET---SGRLAWVEEEMTAISDP----AAY--DV Rv2681 LPSAWLNYAALDVELLIELRAAISRVLAEQGKTDWAAQEFEHLRSFESR----PPP--AA ML1040 LPSDWLNYAALDVELLIELRTAISKVLAEQDKTDWATQEFNYLRTYATRGATTETI--PP mll3296 LSPEQLEYAASDVLYLHRLRDVLAGRLAR---EGRTKEADACFRFLPTR-----A----K CC3603 LSVDQVAYAASDVLHLHGLRLKLNAMLER---EGRMALAQHAFDYLPHR-----A----S RP422 LSLEQKEYAAKDVLYLHQLKDILQKMLLR---ENRLELAHDIFRFLPTR-----V----H sll0320 LSKAQLAYAANDVRYLIPLRHKLEKMLAR---EDRLRLAQRCFECLPVM-----V----T PA1294 LTEMQMRYAADDVQHLAQVYLALDTRLSE---EKRAWLLEDGAELVANL-----CR--ES XF0751 LTPAQLDYAANDVRYLFALHDTLTERLAE---MSRSAWLEEDCTRLTDN------I--EQ RP462 ITNDMLNYAILDVEYLYKIYKELNNIIIS---NNLTHKYQHTLSALLDV----RNY--KV YOR001w_2 LSKPMTAYARADTHFLLNIYDQLRNKLIE---SNKLAGVLYESRNVAKRRFEYSKYRPLT :. ** *. * : : rnd APEDAWRDITN--------AWQLRTRQ-LACLQLLADWRLRKARERDLAVNFVVREEHLW Zrnd APEDAWRDITN--------AWQLRTRQ-LACLQLLADWRLRKARERDLAVNFVVREEHLW VC1984 NPELAYLDIKG--------AWQLKPKE-LAILKPLATWRYHEAVNRDLALNFVIKETDLL HI0390 DSEKAYLDIPN--------AWKLNPLE-LSRLRVLAQWRQNVAIERDLALSYIVKSEHLW PM0706 DPELAYLGIPN--------AWRLTPSE-LMRLKLLAKWRQEEATKRDLALNFVVRAEHLW mll8354 HPEDAWKRLK---------MRLRKPQE-LAIVQAVAAWREREARERDVPRGRVLKDDAIY CC1704 DPEKAWRRLR---------PRKTAPKY-LAVFKAVAAWRERTAQNRDQPRGRILKDEAID Rv2681 ARQDRWRRTSG--------IHKVHDRRGLAAVRELWTARDRIAQRRDIAPRRILPDSAII ML1040 TRRDRWRRTSG--------IRRVRDRRALAAVRELWATRDHIAQRRDIAPRRILPDTAII mll3296 LDLMGWDEEDI--------FAHS------------------------------------- CC3603 LDLAGWEEMDI--------FAHS------------------------------------- RP422 LDLIGWDQIDI--------FMH-------------------------------------- sll0320 LDLGMYG--NV--------FEHGGPG---------------------------------- PA1294 DPREAYREVKL--------GWRLRPQQ-LAVLRELCAWREEQARLRNRPRNHVLRERTLW XF0751 NENERWPHLAIH-------SAQLLDAPAQYRLLRLLRWRETSARTRNKPRNWILNNELAS RP462 ELKDAWKKIR----------YKSDDENFNRTIQVLAAYREENAQTINIPRKHFILDEDLI YOR001w_2 PSSEVYSPIEKESPWKILMYQYNIPPEREVLVRELYQWRDLIARRDDESPRFVMPNQLLA : rnd SVARYMPGSLGELDSLGLSGS--EIRFHGKTLLALVEKAQTLPE-------DALPQPMLN Zrnd SVARYMPGSLGELDSLGLSGS--EIRFHGKTLLALVEKAQTLPE-------EALPQPMLN VC1984 TISRLALRSPKRMEEEGVDPH--AIRRHSSKIIAMVKTALETPA-------DAYPPEIVP HI0390 KVAKNNPRNTSEMLEMGLTEN--EVRVRGKEILQLLSQARRISS-------NDYPKSIER PM0706 QVAKHNPKHTSELLALGLSHH--EVRIHGKKILHLIGQLKRFDD-------VDYPMPIVR mll8354 EVAQQAPRDAAALAKLRTTPKGWERSSTATALLGAVNTALALPK-------EQMPKLPKN CC1704 ELATQTPGNLEALNNLRGVPKGFGGSKFGPDLLAAIKDALADPE-------GYAPVVDKP Rv2681 DAAIADPKSVDDLVALPVFGGR-NQRRSAAVWWAALAAARESPDPPEIAEPANGPPPPGR ML1040 DAAIADPKTIDELIAMPVFGGA-NQRRSAAMWLAALETARQSQDLPDEAEPSNVPPPPGR mll3296 ------------------------------------------------------------ CC3603 ------------------------------------------------------------ RP422 ------------------------------------------------------------ sll0320 ------------------------------------------------------------ PA1294 PLARLLPKNKTDLAAIEDMHPR-TVRQDGDFLIELIAQAARLPQ-------SEWPEALPE XF0751 ILARFPPPNLTELRYQLKKFNK-SWDPLATQILEALHTPVADEA--------QAPLATAP RP462 KLCKNMPLNYKDFKNLKLKSKYLHKKKYKDEIINLFNNL--------------------- YOR001w_2 ALVAYTPTDVIGVVSLTNGVT-EHVRQNAKLLANLIRDALRNIKNTN-EEATPIPSSETK rnd -L------MDMPGYRKAFKAIKSLITDVSETHKISAELLASRRQINQLLNWHWK-LKPQN Zrnd -L------MDMPGYRKAFKAIKSLITDVSETHKISAELLASRRQINQLLNWHWK-LKPQN VC1984 -I------MEYPGYKQLFKRLKDEVKSVSNTSGLATEFLASKKQLNQLLSWVWKRDRDPA HI0390 -I------SEDPRYKKTIRLLQEKVNSLTP-EGLTPEIVASKRTLEELIKWVWKYDCSQD PM0706 -I------ADDPRYKKALKGLQQKLKSIAP-PDLAAEVIASKRGLENLMKWCWLDNQDPT mll8354 -F------QPPEGSSAAAELLKVLLRIVAEKQGVASKVLASSDDIDRIAAEGEDADVPAL CC1704 GP------PPPQNAGAVVELLKVLLKARAEEAGVASKLIATVSDLEKIAAD-DNATTPAL Rv2681 WV------RRKPAAAARLDAARAALTEVSQRVRVPTENLVSP-DLVRRLCWEWEDISQSS ML1040 WA------RRKPDAAARLEAARAALATVSQRVGVPTENLVSP-ELVRRLCWDWEVLPESS mll3296 ------------------------------------------------------------ CC3603 ------------------------------------------------------------ RP422 ------------------------------------------------------------ sll0320 ------------------------------------------------------------ PA1294 --------PLPPEVTPLLKSLRAIGQREAETLGMAPELMLRKKVLEALLKSGYP--DGPY XF0751 ---------SDAD-KALLKQLQKIVAECSYDLGLPEGILASRRHLEALIEQ--------R RP462 ------------------------------------------------------------ YOR001w_2 ADGILLETISVPQIRDVMERFSVLCNSNISKSRAKPVTNSSILLGKILPREEHDIAYSKD rnd NLPE-----------------------LISGWRGELMAEALHNLLQEYPQ---------- Zrnd NLPE-----------------------LISGWRGELMAEALHNLLQEYPQ---------- VC1984 RLPD-----------------------LMQGWRLPLLGEKLNTLVLK------------- HI0390 KRPE-----------------------LLIGWRKPIGEKLVDALK--------------- PM0706 QLPE-----------------------LLVGWRREFGLVLLNTLANG------------- mll8354 QGWRRAVFGEA----------------ALKLVRGEIGIKFDKRKIAVFDL---------- CC1704 TGWRREAFGSD----------------ALKIKRGELALVLDGARVRVVEVRRAPKND--- Rv2681 PDPIAAVEAYLRT-------------GQARAWQLELVVPILTAALTGAPDAGAQGDDGS- ML1040 VDPVNAVEEYLRV-------------GQARAWQRELVVTILASAVKSS--AG-------- mll3296 ------------------------------------------------------------ CC3603 ------------------------------------------------------------ RP422 ------------------------------------------------------------ sll0320 ------------------------------------------------------------ PA1294 ELPD-----------------------SLRGWRRERMGQALLDALESA------------ XF0751 RWPN-----------------------SLGQWRRSLLETQLQPLLSMSDT---------- RP462 ------------------------------------------------------------ YOR001w_2 GLPNKVKTEDIRIRAQNFKSALANLEDIIFEIEKPLVVPVKLEEIKTVDPASAPNHSPEI rnd ------------------------------------------------------------ Zrnd ------------------------------------------------------------ VC1984 ------------------------------------------------------------ HI0390 ------------------------------------------------------------ PM0706 ------------------------------------------------------------ mll8354 ------------------------------------------------------------ CC1704 ------------------------------------------------------------ Rv2681 ------------------------------------------------------------ ML1040 ------------------------------------------------------------ mll3296 ------------------------------------------------------------ CC3603 ------------------------------------------------------------ RP422 ------------------------------------------------------------ sll0320 ------------------------------------------------------------ PA1294 ------------------------------------------------------------ XF0751 ------------------------------------------------------------ RP462 ------------------------------------------------------------ YOR001w_2 DNLDDLVVLKKKNIQKKQPAKEKGVTEKDAVDYSKIPNILSNKPGQNNRQQKKRRFDPSS rnd ------------------------- Zrnd ------------------------- VC1984 ------------------------- HI0390 ------------------------- PM0706 ------------------------- mll8354 ------------------------- CC1704 ------------------------- Rv2681 ------------------------- ML1040 ------------------------- mll3296 ------------------------- CC3603 ------------------------- RP422 ------------------------- sll0320 ------------------------- PA1294 ------------------------- XF0751 ------------------------- RP462 ------------------------- YOR001w_2 SDSNGPRAAKKRRPAAKGKNLSFKR