CLUSTAL W (1.74) multiple sequence alignment AF0588 ----------------MQR-------FEILDKDAMGRICRIETPHG----RIETPTILPV MJ0436_1 ------------------------------------------------------------ PH1116_1 ----------MSRGDKMLK-------FEIKARDGAGRIGKLEVNGK----KIETPAIMPV PAB0740_1 ----------MSRGDKMLK-------FEVKARDGAGRIGKLEVNGK----KIETPAIMPV MTH176_1 ------MISLISRGNTLLMTLWEDFMFEIKSKDGLGRTGILKTEHG----TVRTPALMPV VNG1959G -----------------MRD-----VFEVGAQDGLARIGELDVPRAGV--TVETPTLMPV Ta1493_1 --------------------------MKIEERDGLARIAKFETPHG----PIETPTVLPV TVN1497_1 --------------------------MEIRERDGLARIARFDTPHG----TIETPTVLPV tgt ----------------------MKFELDT--TDGRARRGRLVFDR--G--VVETPCFMPV Ztgt ----------------------MKFELDT--TDGRARRGRLVFDR--G--VVETPCFMPV HI0244 ----------------------MKYELDK--TSGNARRGRLVFERPQGTFSVETPAFMPV PM0229 ----------------------MKYELDK--TDGNARRGRLVFERPQGTFTVETPAFMPV VC0741 --------------------MKLKFELKK--KNGNARRGQLIFER--G--TVQTPAFMPV PA3823 ----------------------MNFELLA--TDGKARRGRLTFPR--G--VVETPAFMPV XF0223 MGVLFVIRDNGRPLSCACRMSRLQFQLQA--TDGAARRGQLSFPC--G--TVQTPAFMPV BU133 ----------------------MNFKVLY--QDNNARCGVFNFNQ--E--IIETPVFMPV NMB0719 ---------------------MLKFTLHK--KDGLARRGTLELNH--G--KIETPVFMPV NMA0928 ---------------------MLKFTLHK--KDGYARRGTLELNH--G--KIETPVFMPV mll0721 ------------------MAKPFSFKVLA--TDGRARRGIIDMPR--G--EIRTPAFMPV CC1588 -------------------MAAFPFEIEA--TDGKARTGVLKTPR--G--DIRTPAFMPV RP721 -------------------MSKFSFTIHS--HYKKARSGVITTAH--G--EIRTPAFMPV aq_1308 ---------------------MFKFHLIT--KDGKARRGRIYTPH--G--VIETPVFMPV BS_tgt ---------------MAEQPIRYEFIKEC--KQTGARLGKVHTPH--G--SFETPVFMPV BH1228 ---------------MAA--VTYELIKTC--KQSGARLGKLHTPH--G--TIETPIFMPV L0361 ---------------MTEHAIKYRLIKKE--KHTGARLGEIITPH--G--TFPTPMFMPV SPy0203 ---------------MTDYPIKYRLIKAE--KHTGARLGEIITPH--G--TFPTPMFMPV slr0713 -------------MPLPSVNFTYQCQARC--SHSQARAGIFQTPH--G--PVETPRFMPV DR2578 ------------MNQCGTITAVFEFEIKQ--RDGRARTATFQTPR--G--AVTTPMFMPV AF1485 --------------------MPLKFRIKH--TLDRMRVGKVKTRH--G--SFETPVFIPV TM1561 ----------------------MEFEVKK--TFGKARLGVMKLHH--G--AVETPVFMPV jhp0266 ----------------------MDFQLQA--VDDNARAGVLNLAHS----QVETPVFMPV HP0281 ----------------------MDFQLQA--TDNNARAGLLNLAHS----QVATPVFMPV Cj1010 ----------------------MEFKLKH--KDGMARVCEITTAHS----TFLTPVFMPV CT193 --------------------MALRFEILHQSKKSRARVGRIETAH--G--YIDTPAFVPV CPn0219 --------------------MALKFHLIHQSKKSQARVGQIETSH--G--VIDTPAFVPV BB0809 -----------------------MFSVIKNDKHFNARVGFLNLPHG----RVDIPCFMPV APE2017 -----------------------MFEIRD--VDLAGRIGRIYTQHG----VVETPAFFPV MTH1877 ------------------------------------------------------------ AF0588 INPNIPFIRAEEMK-KFG-AQAVITNSYIIYR--SMREEALEKGVHGILETDMPVMTDSG MJ0436_1 ------------------------------------------------------------ PH1116_1 VNPKQMVVEPKELE-KMG-FEIIITNSYIIYKDEELRRKALELGIHRMLDYNGIIEVDSG PAB0740_1 VNPKQLIVEPKELE-KMG-FDIIITNSYIIYKDRELREKALEVGIHKLLGYDGIIEVDSG MTH176_1 IHPGKQTIDVK----GPG-AEIVITNAYIIYRNPELRERALSDGVHRLIDFDGPIMTDSG VNG1959G VNPNLITVEPSRFVDEFG-AELLITNSYIINSDDDLRERALDEGLHEMLGFDGAIMTDSG Ta1493_1 INPNIMNITPQEMK-PLG-LQGIITNSYIILRTPELRERALREGLHSLIGYDGPIMTDSG TVN1497_1 INPNIMDITPEEMK-KYG-VHGVITNSYIILRNDRLREEAEKYGVHSLIGYDGPVMTDSG tgt GTYGTVKGMTPEEVEATG-AQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSG Ztgt GTYGTVKGMTPEEVEATG-AQIILGNTFHLWLRPGQEIMKLHGDLHDFMQWKGPILTDSG HI0244 GTYGTVKGMTPEEVRATG-AEILLGNTFHLWLRPGQEVMRKHGDLHDFMQWHRPILTDSG PM0229 GTYGTVKGMTPEEVRATG-AEILLGNTFHLWLRPGQEVMRKHGDLHDFMQWHRPILTDSG VC0741 GTYGTVKGMTPEEVKETG-AQILLGNTFHLWLRPGQEVMKMHGDLHDFMNWQGPILTDSG PA3823 GTYGTVKGMLPRDIEDIG-AQIILGNTFHLWLRPGTEVIQRHGDLHDFMQWKGPILTDSG XF0223 GTYGAVKGVLPGQLCDLG-AEIILGNTFHLFLRPGLEVIADHGGLHGFMRWNGPILTDSG BU133 GTYGAVKSISTEEIKNTG-SRIILSNAFHLYFRPGLEIIKLHGNLHNFMNWSGPILTDSG NMB0719 GTYGSVKAMNPQNLHDIK-AQIILGNTYHLWLRPGLEVIGQFGGLHGFIGWDKPILTDSG NMA0928 GTYGSVKAMNPQNLHDIK-AQIILGNTYHLWLRPGLEVVEQFGGLHGFIGWDKPILTDSG mll0721 GTGGTVKTMYMDQVRGVG-ADIILGNTYHLMLRPGAERVARLGGLHEFARWPHPILTDSG CC1588 GTAATVKAMTVDQVKDTG-ADIILGNTYHLMLRPSAERVKRLGGLHKFMRWDKPILTDSG RP721 GTRGAVKAMLTEAVVETG-ADILLGNTYHLMLQPSAERIAYLGGLHKFMNWDKPILTDSG aq_1308 GTQGTVKAMLHKLLDEIG-TQIILGNTYHLYLRPGTEIIKKAGGLHRFISWNKPILTDSG BS_tgt GTLATVKTMSPEELKAMD-AGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSG BH1228 GTLATVKTMSPEELKQLG-AQIILSNTYHLWLRPGHDIVKEAGGLHEFMNWDRPILTDSG L0361 GTQATVKTMSPEELKTLG-SGIILSNTYHLWLRPGDELVAEAGGLHKFMNWDQPILTDSG SPy0203 GTQATVKTQSPEELKAIG-SGIILSNTYHLWLRPGDELIARSGGLHKFMNWDQPILTDSG slr0713 GTLATVKGITPAQLADTQ-AQMVLANTYHLHLQPGEKIIAAAGGVHKFMGWSGPMLTDSG DR2578 GTQGTVKGISPQELLEIG-SQMILANTYHLMLRPGEQLVKAHGGLPGFTAYPGPFLTDSG AF1485 ATLAAIRGLDNRDLKDMG-VEVILANTYHLHLRPGDELIKELGGLHKFMNFDGVIVTDSG TM1561 GTNASVKLLTPRDLEEAG-AEIILSNTFHLMLKPGVEIIKLHRGLHNFMGWKRPILTDSG jhp0266 GTQGCIKSLDAMDAQEILGAKLILANTYHMYLRPGEKVVEQLGGLHRFAQFQGSFLTDSG HP0281 GTQGCIKSLDATDAQEILGAKLILANTYHMYLRPGEKVVEELGGLHRFAQFYGSFLTDSG Cj1010 GTVGAVKSLDANDMKNELDAKIILANTYHMYLRPTSKVVKDFGGLHGFTKFDRSFLTDSG CT193 ATNGALKGVL--DHSNIP---LMFCNTYHLIVHPGAEAIAAMGGLHQFIGRNAPIITDSG CPn0219 ATHGALKGVI--DHSDIP---LLFCNTYHLLLHPGPEAVAKLGGLHQFMGRQAPIITDSG BB0809 GTLGAMKGLKHAVLEKLE-CNLMLANTYHLYLRLGIKTVEKYVGLHNFTIWNKNFLTDSG APE2017 IDVYRQEVSVD-EVRAAG-FGQVITNAYLLWKRFGWEAAEK--GVHRILGFPGVVMTDSG MTH1877 -----------------------------------------------MIMSRYQIKLHDG AF0588 SYQLMVYGD----------------------------------------------VEIK- MJ0436_1 ------------------------------------------------------------ PH1116_1 SFQLMKYGS----------------------------------------------IEVS- PAB0740_1 SFQLMRYGN----------------------------------------------VDVS- MTH176_1 SFQLSEYGD----------------------------------------------IEVE- VNG1959G SFQLAEYGE----------------------------------------------IDTD- Ta1493_1 TFQSYVYGS----------------------------------------------IEFN- TVN1497_1 TFQSYVYGS----------------------------------------------VEFN- tgt GFQVFSLGD--------------------------------IRKITEQGVHFRNPINGDP Ztgt GFQVFSLGD--------------------------------IRKITEQGVHFRNPINGDP HI0244 GFQVFSLGK--------------------------------LRKITEEGVKFQNPINGER PM0229 GFQVFSLGK--------------------------------LRKITEEGVKFQNPINGER VC0741 GFQVFSLGD--------------------------------IRKITEEGVHFRNPVNGDK PA3823 GFQVFSLGA--------------------------------MRKIKEEGVTFASPVDGAK XF0223 GFQVFSLAH--------------------------------RRKISEQGVTFAAPTDGAQ BU133 GFQVFSLSR--------------------------------FCKVNEEGVIFQNHIDGKK NMB0719 GFQVFSLSD--------------------------------MRKLTEEGCTFKSPINGDK NMA0928 GFQVFSLSD--------------------------------MRKLTEEGCTFKSPINGDK mll0721 GFQVMSLSK--------------------------------LRKLTEKGVTFRSHIDGAP CC1588 GFQVMSLSG--------------------------------ISKLTEEAVTFSSHVDGSK RP721 GFQVMSLSK--------------------------------LCKITEEGVSFRSHINGNK aq_1308 GYQVFSLAKGKFGNRKA------------------------KVKVSDEGVEFQDHLQGDK BS_tgt GFQVFSLSKFR--------------------------------NIEEEGVHFRNHLNGDK BH1228 GFQVFSLSDLR--------------------------------TIEEEGVHFRNHLSGEK L0361 GFQVYSLVQNKK-------------------------------NITEEGVKFKSHLDGRE SPy0203 GFQVYSLADSR--------------------------------NITEEGVTFKNHLNGSK slr0713 GFQVFSLSQLR--------------------------------TIGEQGVLFRSPRDGRL DR2578 GFQVMSLGHMR--------------------------------KISEEGVVFKNHLDGSR AF1485 GFQAFSLGFGMEHGVGKIANNIFLEELREERLREAENERKKLAVVTDRGVRFKDPKSGRI TM1561 GFQVFSLPKIR---------------------------------IDDEGVVFRSPIDGSK jhp0266 GFQAFSLSD--------------------------------NVKLQEDGIVFKSHIDGSK HP0281 GFQAFSLSD--------------------------------NVKLQEDGIVFKSHIDGSK Cj1010 GFQAFSLSK--------------------------------NSKHFNEGIEFKSHIDGSR CT193 GFQIFSLAYGSVAEEIKSCGK------KKGG--------NTIIKVNDDGVHFKSYRDGRK CPn0219 GFQIFSLAYGSVAEEIKSCGK------KKGM--------SSLVKITDEGAWFKSYRDGRK BB0809 GFRVFSFSD--------------------------------LRKIDLKGVHFKSHIDGSY APE2017 AYQILEYGG----------------------------------------------VELS- MTH1877 PARLGLLDD------------------------------------------------TE- AF0588 ---NA-EIVEFQR-HIGSDIIVPLDIPTPPDADYATAESDLRITLEREREAKEL--LKGA MJ0436_1 ----M-EIIEFQE-RIGVDVGTILDIPTPPDVDRERAEKELEETLKRAKASIELKEERGF PH1116_1 ---NR-EIIEFQH-RIGVDIGTFLDIPTPPDAPREQAVKELEITLSRAREAEEIK----- PAB0740_1 ---NR-EIVEFQH-RIGVDIGTFLDIPTPPDAPKEKAMEDLKITLERAREAEEIK----- MTH176_1 ---NP-EIIRFQD-EIGTDIGTSLDIPTPPGVSHRRAIEEVEVTLERARESIEYR----E VNG1959G ---TE-AILRFQH-DIGSDIGTPVDIPTPPDADREQAAAELETTQQRLELAETVDVG--- Ta1493_1 ---NR-EVVDFQR-RIGSDISTILDVFTTPGTPKPEAEKAVIETYNRMLEVNDE------ TVN1497_1 ---NR-QVVEFQK-TIGSDILTILDIFTTPSSSRQEVENAITETYRRMLEVNDA------ tgt IFLDPEKSMEIQY-DLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRERFDSLGN Ztgt IFLDPEKSMEIQY-DLGSDIVMIFDECTPYPADWDYAKRSMEMSLRWAKRSRERFDSLGN HI0244 IFLSPEKSMEIQY-DLGSDIVMIFDECTPYPATFDYAKKSMEMSLRWAKRSRDRFDELGN PM0229 IFLSPEKSMEIQY-DLGSDIVMIFDECTPYPATFDYAKKSMEMSLRWAKRSRDRFDELGN VC0741 IFMDAEKSMEIQK-DLGSDIVMIFDECTPYPATHDEAKKSMEMSLRWAKRSRDHFDKLEN PA3823 VFMGPEESMAVQR-ALGSDIVMIFDECTPYPADHDVAKRSMELSLRWAKRSK--IAHGDS XF0223 VFLGPEESMKIQK-VLNSDIVMIFDECTPYPATEDVARDSMELSLRWAQRSRDAHDALDN BU133 TFLTPKISMKIQS-DLGSNIVMIFDQCIEYNQNWEKTKNAMERSLYWAKKSRIYFDSYKN NMB0719 LFLSPEISMKIQT-VLNSDIAMQLDECTPGEATREQARKSLQMSLRWAERSKKAFEDLKN NMA0928 LFLSPEISMKIQT-VLNSDIAMQLDECTPGEATREQARKSLQMSLRWAERSKKAFEDLKN mll0721 YEMSPERSIEIQS-LLDSDIQMQLDECTALPAELKEIERAMELSLRWAERCKTAFGDQPG CC1588 HVLTPERSIEIQADLLGSDIVMQLDECVAWPAEEARARKGMELSARWAKRSKDAFGTRDT RP721 YMLTPEYSTEIQY-LLGSTITMALDECTPYPSTFEKAKTSMHLTTRWANRSRDAFVKREG aq_1308 HFFTPEKVVEIQE-IFGSDIMMPLDECVEYPVDKNYAEKALKRTINWLERSIK--AKKRE BS_tgt LFLSPEKAMEIQN-ALGSDIMMAFDECPPYPAEYDYMKRSVERTSRWAERCL-NAHNRQD BH1228 LFLSPEGAMEIQN-ALGSDIMMAFDECPPYPAERDYMRPSVERTSRWAERCL-KAHKRPE L0361 LFLNPEKAISIQN-NLGSDIMMSFDECPPFYQPYDYVKASVERTSRWAERGL-NAHRRPN SPy0203 MFLSPEKAISIQN-NLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGL-KAHRRPH slr0713 IDMTPENSIRIQN-ALGADVIMAFDECPPGQGDRLMVEQATARTYRWLERCI-EAHQRPG DR2578 VELTPERSIQVQE-ALGADVIMAFDECPPYPAERPYIEASLDRTVRWLERCH-AVKTKD- AF1485 VELTPKKSMEIQS-NLGSDIIFAFDECTSPLSDRDYTEKALERTHRWAEECL-QHYDRR- TM1561 VFLNPEISMEVQI-ALGSDICMVFDHCPVPDADYEEVKEATERTYRWALRSK-KAFKTEN jhp0266 HLFTPIKVLDIQY-SLNSDIMMVLDDLVGLPAPLKRLEESIKRSAKWANMSLEYHKENNR HP0281 HLFTPAKVLDIQY-SLNSDIMMVLDDLVGLPAPLKRLEESIKRSAKWANMSLEYHKEKNR Cj1010 HLFTPKSVLDTQY-DFNSDIMMILDDLVALPATKERVKISVDRTILWAKEAITYHKNMQN CT193 LFLSPEISVQAQK-DLGADIILPLDELLPFHADPTYFHQSSQRTYVWEKRSLDYHLKNPG CPn0219 LFLSPELSVQAQK-DLGADIIIPLDELLPFHTDQEYFLTSCSRTYVWEKRSLEYHRKDPR BB0809 HYFTSEGIFAMQE-IFGSDIIMPLDICSSYGIDYNEANLYTNITTNWASSTFKSSKNRKE APE2017 ----QGEVVEYQK-RLGSDIAVILDIPTG-DVGRREAEESVRETIRRALEARVMIEGDE- MTH1877 ------TPLLLEH----DGMEIAPHETIPYSVPREIAEWGVDETLRMASGSA-------- : : . : AF0588 -----ENLLAVPVQGSTHPDLRRFAAGEARKIG--GDIYPIGAVVPLMDAYRFRDLARVI MJ0436_1 -----KLLLNGTVQGSTYLDLRQKSAKEMAKLG--FDIYPIGAVVPLMEQYRYRDVAEII PH1116_1 -----EIPMNATIQGSTYTDLRRYAARRLSSMN--FEIHPIGGVVPLLESYRFRDVVDIV PAB0740_1 -----EIAMNAAIQGSTYTDLRRYAARRLSSMN--FEIHPIGGVVPLLEAYRFREVVDIV MTH176_1 -----RMMLNAVVQGSTHPDLRRYCASRLAELP--VELHPIGAVVPLMESYRYRELVDAV VNG1959G -----DMLVNAPVQGATQPDLREQAGAHAYGTA--LDLFPVGAVVPLMNQYRYDDMTEAV Ta1493_1 -----EGIIAGPVQGGVYPDLRQKSAELMNSTN--AGYHPIGGVVPLLETYDYSTLVDII TVN1497_1 -----GGMIAGPIQGGIYPDLRKRSAELMNSTN--ASYLPIGGVVPLLESYEYDKLVDII tgt K-----NALFGIIQGSVYEDLRDISVKGLVDIG--FDGYAVGGLAVGEPKADMHRILEHV Ztgt K-----NALFGIIQGSVYEDLRDISVKGLVDIG--FDGYAVGGLAVGEPKADMHRILEHV HI0244 K-----NALFGIIQGGVFEELRKVSLEGLVNIG--FDGYAVGGLAVGEPKEDMHRILEYI PM0229 K-----NALFGIIQGGVYEELRKVSVEGLVNIG--FDGYAVGGLAVGEPKEDMHRILEYV VC0741 P-----NNLFGIVQGGVYEDLRDVSVKGLTEIG--FDGYAVGGLAVGEPKEDMHRVLEHT PA3823 P-----SALFGIVQGGMHEDLRLRSLDGLQEIG--FDGLAIGGLSVGEPKEEMIRVLDFL XF0223 D-----AALFGIIQGGVHPDLRGRSLDGLQAIG--FDGYGIGGLAVGESESERNVILEYL BU133 K-----NSLFGIIHGGIYPSLRDISLQELIKID--FDGYALGGLAVGEPKIEMYKLLDHI NMB0719 P-----NALFGIVQGAMYEDLREESLRGLEQFD--FPGLAVGGLSVGEPKPEMYRMLRAV NMA0928 P-----NALFGIVQGAMYEDLREESLKGLEELD--FPGLAIGGLSVGEPKPEMYRMLRAV mll0721 K------AMFGIVQGGDNAALRVRSAQALSAMG--LKGYAVGGLAVGEPQAVMLEMLDIT CC1588 Q------VLFGIQQGSTFENLRRESSERLREIG--FDGYAIGGLAVGEGHQAMCEVLDYA RP721 Y------AQFGIIQGSVYKELREQSVKDLVKCD--FEGYAIGGLAVGEGQELMFRVLDYV aq_1308 D-----QVLFGIVQGAFWKDLRKKAVEETLKFDEFLFGYSIGGLSVGEPKEIMYGMTEVV BS_tgt E-----QGLFGIVQGGEYEDLRTQSAKDLISLD--FPGYAIGGLSVGEPKDVMNRVLEFT BH1228 D-----QALFGIIQGGEYEDLRRQSAQDITSLD--FPGYAIGGVSVGEPKDVMNRVLEFT L0361 D-----QGLFGIVQGAGFEDLRRQSARDLTSMD--FAGYSIGGLAVGESHKEMNAVLDFT SPy0203 D-----QGLFGIVQGAGFEDLRRQSAADLVAMD--FPGYSIGGLAVGESHEEMNAVLDFT slr0713 D-----QALFGIVQGGTYLDLRSQAAEQLIALD--LPGYAIGGVSVGEAPALIDKVVQHT DR2578 D-----QALFAIVQGGVHEDLRLKSLEATLPFA--TPGFAVGGLAVGESKEEMYPAVAFT AF1485 ------QALFGVVQGGEYRDLREKSARFMAERD--FAGYGIGG-SLGKSKQDMLNILDWV TM1561 ------QALFGIVQGGIYPDLRRESALQLTSIG--FDGYAIGGLSIGEERSLTLEMTEVT jhp0266 P----NNNLFAIIQGGTHLKMR-SLSVGLTHEG--FDGYAIGGLAVGESVDEMLETIAHT HP0281 P----SNNLFAIIQGGTHLKMR-SLSVGLTHEG--FDGYAIGGLAVGESADEMLETIAHT Cj1010 KGIGIGQNIFGIIQGGTDYEERKRCALSLNEMP--FDGLAIGGLSVGEENALMYETVQNL CT193 I-----QSMYGVIHGGTFPDQRKLGCKFVEDLP--FDGSAIGG-SLGKNLQDIVEVVGVT CPn0219 H-----QSMYGVIHGGLDPEQRRIGVRFVEDEP--FDGSAIGG-SLGRNLQEMSEVVKIT BB0809 G---YNGLLFLITQGNFFKDLRKRSINDILELD--SPGIAIGGISVGEPREKYLEILEYS APE2017 ------RIWVYPVQGGRYFDLVEESARVGGRLG-FYRMYGIGSPTVFLERYMYHVVVEAV MTH1877 -------ADYAFIHGSSYQDLRIRCALELEEMG--FRRLIVANMDELLQRPGDLVRILTA :* :. AF0588 LEVRSALPV-EPIHLFGCGHPMLFAMAVALGCDLFDSAAYALYAKDDRYLTV--YG---- MJ0436_1 INSKMYLPTNKPVHLFGCGHPMFFALAVALGCDLFDSAAYALYAKDDRYLTE--RG---- PH1116_1 ISSKMALRPDRPVHLFGAGHPIVFALAVAMGVDLFDSASYALYAKDDRYMTP--EG---- PAB0740_1 ISSKMALRPDRPVHLFGAGHPMVFALAVAMGVDLFDSASYALYAKDDRYLTP--EG---- MTH176_1 LSSVSELPPSRPRHLMGAGHPMLFALAVSMGCDLFDSAAYILYAEDDRLLST--EG---- VNG1959G LAAKRGLGRDAPVHLFGAGHPMMFALAAALGCDLFDSAAYAIYARDDRYLTV--SG---- Ta1493_1 INSKINLSFNKPVHLFGGGHPMFFAFSVYLGVDLFDSASYIKYAKDDRLIYP--DG---- TVN1497_1 LNSKLNVSFGKPIHLFGGGHPMFFAFAVYLGVDLFDSASYVKYAKDDRLIYP--DG---- tgt C---PQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVT--DG---- Ztgt C---PQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVT--DG---- HI0244 C---PQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVT--DG---- PM0229 C---PQIPADKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVS--DG---- VC0741 C---PQLPEDKPRYLMGVGKPEDLVEGVRRGIDMFDCVMPTRNARNGHLFVT--GG---- PA3823 P---PQMPADKPRYLMGVGKPEDLVEGVRRGVDMFDCVMPTRNARNGHLFVD--SG---- XF0223 H---PRVPADRPRYLMGVGRPEDLVESVARGVDMFDCVMPTRHARNGQYFTG--FG---- BU133 C---PQIPKNKPRYLMGVGKPEDLIEGVRRGVDMFDCVIPTRNARNGHLFVT--NG---- NMB0719 G---PILPEHKPHYLMGVGTPEDLVYGVAHGIDMFDCVMPTRNARNGWLFTR--FG---- NMA0928 G---PILPEHKPHYLMGVGTPEDLVYGVAHGVDMFDCVMPTRNARNGWLFTR--FG---- mll0721 C---PELPADKPRYLMGVGTPDDILKSVARGIDMFDCVMPTRAGRHGLAYTR--RG---- CC1588 P---GFLPEDRPRYLMGVGKPIDLVEAVARGVDMFDCVLPTRSGRHGQAWTW--DG---- RP721 P---DFLPQNKPRYLMGVGKPSDIIGAVSRGIDMFDCVIPTRSGRNGQAFTK--YG---- aq_1308 C---ELLPEKKPRYLMGVGKPEDILEAVERGVDMFDCVVPTRNARTGTLYTS--QG---- BS_tgt T---PLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTRIARNGTVFTA--EG---- BH1228 T---PLLPANKPRYLMGVGSPDSLIDGAIRGIDMFDCVLPTRIARNGTCMTS--NG---- L0361 T---PMLPEDKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTLMTH--FG---- SPy0203 T---PLLPENKPRYLMGVGAPDSLIDGVIRGVDMFDCVLPTRIARNGTCMTS--EG---- slr0713 A---PLLPAHKPRYLMGVGTYREMARAIFAGIDLFDCVIPTRFGRHGTALVQ--GE---- DR2578 A---GRLPENKPRYLMGVGHPEDLVAGVALGIDMFDCVYPTRTGRFGYALTD--DG---- AF1485 I---PLLPEEKPRHLLGIGAIEDLFNCTEKGVDMYDCVAPARWARRGHLYVSPAEGGNVR TM1561 V---EFLPEDKPRYFMGGGSPELILELVDRGVDMFDSVFPTRIARHGTALTW--NG---- jhp0266 A---PLLPKDKPRYLMGVGTPENILDAISLGVDMFDCVMPTRNARNATLFTH--SG---- HP0281 A---PLLPKDKPRYLMGVGTPENILDAISLGVDMFDCVMPTRNARNATLFTH--SG---- Cj1010 N---PYLDENRPRYLMGVGTPEDLVENVERGVDMFDCVMPTRNARNGTFFTS--FG---- CT193 A---ANLSAERPRHLLGIGDLPSIWATVGFGIDSFDSSYPTKAARHGMILTS--QG---- CPn0219 T---SFLSKERPVHLLGIGDLPSIYAMVGFGIDSFDSSYPTKAARHGLILSK--AG---- BB0809 F---LLIPKEKPRYVMGIGTPHYILNAIYYGIDIFDCFNPARITRHGSLLTD--NG---- APE2017 YRAKKHLPWGRPVHLFGAGHPLIFPYAVALGVDTFDSASYILYAREGRYITE--YG---- MTH1877 L---RESLKPETLLCSTFSHPAFIPILTYMGMDLFSDATAELYGRLNILLTES------- . . : * * :. . AF0588 ------T--KKLSELN---YFPCKCPVCSN-HDPEELRRMEKNER---ERLIAEHNLYVS MJ0436_1 ------T--LHLEEIKDLKAFPCSCPVCSS-YTPKELASLNKKER---ERLLAEHNLYVT PH1116_1 ------T--KRLDELD---YFPCSCPVCSK-YTPQELREMPKEER---TRLLALHNLWVI PAB0740_1 ------T--KRLDELE---YFPCSCPVCSR-YTPQELREMPKEER---ARLLAIHNLWVI MTH176_1 ------T--YKLENLQ---EMPCSCSVCTD-YTPSELMGMDREER---RNLIAEHNLHVS VNG1959G ------T--EHLDDLH---YFPCDCPVCAE-HSPQAVRGMAAGDR---ERLLAEHNLHVS Ta1493_1 ------T--RDLARIT---ELPQWSPLYDR-YTVKEIRDLDKERR---SLEIARHNLKAI TVN1497_1 ------T--RDLARII---EIPEWSPLFDK-YTVKELKELPKEQR---SVELSRHNLKAI tgt ---VVKIRNAKYKSDTGPLDPECDCYTCRN-YSRAYLHHLDRCNEILGARLNTIHNLRYY Ztgt ---VVKIRNAKYKSDTGPLDPECDCYTCRN-YSRAYLHHLDRCNEILGARLNTIHNLRYY HI0244 ---IVKIRNAKYRDDTSPLDPECDCYTCKN-YTKAYLYHLDKCGEILGARLNTIHNLRYY PM0229 ---IVKIRNAKYREDTSPLDPECDCYTCKH-YTKAYLYHLDKCGEILGARLNTIHNLRYY VC0741 ---VIKIRNAAHKTDTTPLDPHCDCYTCKN-YSKSYLHHLDRCNEILGARLNTIHNLRYY PA3823 ---VIKIRNSVHKHDDSTLDPTCDCYTCKH-FSRAYLHHLDKCGEMLGSMLNTIHNLRHY XF0223 ---TVKIRNACYARDVDPIEPGCGCPACVGGYTRAYLRHLDRCNEMLASMLGTLHNLWYY BU133 ---VIKIRNKKYKKDLSCLDNTCVCYTCRY-YSRSYLHHLDACNEILGARLNTIHNLHYY NMB0719 ---DLKIKNAKHKLDKRPIDESCTCYACQN-FSRAYLHHLHRTGEILGAQLNTIHNLHFY NMA0928 ---DLKIKNAKHKLDKRPIDESCTCYACQN-FSRAYLHHLHRAGEILGAQLNTIHNLHFY mll0721 ---KVNLRNARHADDPRPLDEESDCPAARD-YSRAYLHHLVRSQEALGAMLLTWNNLSYY CC1588 ---PINLKNAKYAEDETPLDPDSDCPASRD-YSKAYLRHLFKAEEILGQVLLSWHNIAFF RP721 ---TVNIRNSKYADDKEPLEHDCKCPACTN-YTKAYLHHLVRIREILGPMLMTWHNLTYF aq_1308 ---VVDIRHSKWKEDFSPLDPECDCYTCRN-FSKAYLRHLFVAEEISAYVLNTIHNLRFY BS_tgt ---RLNMKNAKFERDFRPIDEECDCYTCKN-YTRAYIRHLIRCNETFGLRLTTYHNLHFL BH1228 ---RLVVRNAKYARDFRSLDENCDCHVCQT-YTRAYIRHLVKCDETFGFRLTTYHNLYFL L0361 ---RVNIRNAKYEHDFTPLDPMCDCYTCTN-YTRAYLRHLIKADETFGLRLCSYHNLHFL SPy0203 ---RLVIKNAKFAEDFTPLDHDCDCYTCQN-YSRAYIRHLLKADETFGIRLTSYHNLYFL slr0713 ---RWNLKNATFREDHRPLDETCPCYTCQT-FSRAYLNHLIRSREMLGYILLSLHNITEL DR2578 ---RLNLNSSAPRTQLQPIDAECDCYACRH-YTRAYLAHLLRAEEMLAPRMLSLHNLRYL AF1485 NKFRIHIKNAAFRIDNRPVDRTCDCLVCQN-YSRAYLRHLYKANELLYFRLATYHNIYFV TM1561 ---KLNLKASYNKRSLEPVDERCGCYTCKN-FTRSYIHHLFDRGEVLGQILLTIHNINFM jhp0266 ---KISIKNAPYKLDDTPIEENCACYACKR-YSKAYLHHLFRAKELTYARLASLHNLHFY HP0281 ---KISIKNAPYKLDNTPIEENCACYACKR-YSKAYLHHLFRAKELTYARLASLHNLHFY Cj1010 ---KFNIKKAEFINDHEVIDSTCSCYTCRN-FSRGYLNHLFKAKELTFFRLASLHNLHYY CT193 ---PLKINNQRYSSDLNPIEPGCSCLACSQGITRAYLRHLFKVHEPNAGIWASIHNMHHM CPn0219 ---PIKIGQQKYSQDSSTIDPSCSCLTCLSGISRAYLRHLFKVREPNAAIWASIHNLHHM BB0809 ---IMCIGRKEYKDDTSKVEKNCICTLCKR-YSRGYLRHLIKSKELFGIVLASEHNIHYM APE2017 --------VYRIEDLD---YLPCSCPVCSR-YTPQELREMDRVER---TRLLALHNLYVI MTH1877 ---------HTYPLDT---YGICDAGAGDLMERNRHTLELIISEVREHIRNGTLRNLVEE . : : .*: AF0588 FQEIETIKQAIKENSLFELVEKRVRAHPNMLAGWRQVKHYWELLEK--ADPKMKR-KFLY MJ0436_1 FEEINRIKQAIRDGSLWELVEERVRCHPKLLEAYRVVRKYIDYIEK--FDPVTKKSAFFY PH1116_1 KEEIKRVKQAIKEGELWRLVDERARSHPKLYSAYKRLLEHYTFLEE--FEPITKKSALFK PAB0740_1 KEEIERIKQAIREGELWRLVDERARSHPKLYSAYKRLLDHYTFLEE--FEPVTKKSAVFK MTH176_1 FAEIRKVRQAIHDGNLMELVEERCRAHPRLLEGYRRMSEYLDLIEK--FEPRSKRSAFFY VNG1959G FGEIRRVKQAIKSGTLMELVAARAHAHPSTLDGYRALLDHSDQLEA--SDPASKD-AFFY Ta1493_1 FMEISEIKERIYEEGLAQYVAQKARSHPSLMKAYSRIMSYSNILEK--YEDLSKKTAYFF TVN1497_1 FMEISEIRERIYEESMDQYLAQKAKSHPSLLKAYVKVMQYSKMLEK--YQDLFKKAAYFF tgt QRLMAGLRKAIEEGKLESFVTDFYQRQGREVPPLNVD----------------------- Ztgt QRLMAGLRKAIEEGKLESFVTDFYQRQGREVPPLNVD----------------------- HI0244 QRLMAEIRQAIEDDRFDDFVVEFYARMGKPVPPLQLADKS-------------------- PM0229 QRLMAQIRQAIEEDRFEAFVQEFYAKMGKPVPPMQSEIKSDEG----------------- VC0741 QRLMESIRKAIDEDRFDQFVAEFYARRNREVPPLQKDKA--------------------- PA3823 QRVMAGLREAIQQGTLAAFVDAFYAKRGLPTPPLDA------------------------ XF0223 ETLMANMRAAITAGTFFAFRRSFYLARGLDLPPLPEVAGCAG------------------ BU133 QTLMSNIRNSIKNNTFEQFSVNFYKQKNKIDF---------------------------- NMB0719 QVIMAEMREAVEQGKFADWQARFHENRARGTD---------------------------- NMA0928 QVIMAEMREAVEQGKFADWQAQFHENRARGTD---------------------------- mll0721 QKLMQDIRAAIETQTFEARGAEITEGWARGDIPVL------------------------- CC1588 QALTAAMRAAIAEGRFEQFRRDFAARHLGG------------------------------ RP721 QNLMSRIRTYIKLGKDFDFVH--------------------------------------- aq_1308 LKMMEEVRKAIEEKRFKELKEKYLQRVKNKL----------------------------- BS_tgt LHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF----------------------- BH1228 LKLMKDVRQAILDDRLLDFREEFFEQYGFNQPNAKNF----------------------- L0361 VNLMKDVRGAIMDDNLLEFREDFCERYGYNQPNAKDF----------------------- SPy0203 VNLMKKVRQAIMDDNLLEFRQDFLERYGYNKSN-RNF----------------------- slr0713 IRFTQSIRQAILNDTFTQDFAHWLTPPE-------------------------------- DR2578 HRLVERMRVAINGQQFHPWAADWSERYFHGNVPGWFTSAFERSTQS--EI---------- AF1485 VKLMERIRESIADGSFYELKREWLGF---------------------------------- TM1561 ISLMKEVRRSIESGTFKELKSKVVEVYSSGGVNV-------------------------- jhp0266 LELVKNARNAILEKRFLSFKKEFLEKYHSCSH---------------------------- HP0281 LELVKNARNAILEKRFLSFKKEFLEKYNSRSH---------------------------- Cj1010 LELARKMREAILNNSFTQFKRNFYHLRGK------------------------------- CT193 QKVMREIREGILNDRI-------------------------------------------- CPn0219 QQVMKEIREAILKDEI-------------------------------------------- BB0809 FRLISKIRAAILNDDFLNFRTSYLKKYEEENFDE-------------------------- APE2017 SASMRRVKQAIREGRLWELLEETSRKHPSTARVMARMRRYIDALEKGSARGRGVVRGVRA MTH1877 RAASSPQNMSALR-ILDREKQEFLQRYTPLY----------------------------- . AF0588 TGIDSLYRPAVRRHVKAIKNVELPEEVLVSTDFG----IYAN----------------IY MJ0436_1 TGIESMFRPEVLRHKKRLKRLR-----------------YEK----------------VY PH1116_1 ISNESLRWPVVRRAKERAKSIN-------------------------------------- PAB0740_1 ISHESLRWPLVRRARERAERVN-------------------------------------- MTH176_1 TGPESLGRVEVHRHLKRVKEHLG------------------------------------E VNG1959G TGAGSARRPEVHRHHQRLDRLDVDGDDVLLTEGDSNHRYDES----------------WN Ta1493_1 YDSFSTRNPYVSRINRFTESYLS------------------------------------- TVN1497_1 YDSFSTKNTYVARLEKFTSKYLT------------------------------------- tgt ------------------------------------------------------------ Ztgt ------------------------------------------------------------ HI0244 ------------------------------------------------------------ PM0229 ------------------------------------------------------------ VC0741 ------------------------------------------------------------ PA3823 ------------------------------------------------------------ XF0223 ------------------------------------------------------------ BU133 ------------------------------------------------------------ NMB0719 ------------------------------------------------------------ NMA0928 ------------------------------------------------------------ mll0721 ------------------------------------------------------------ CC1588 ------------------------------------------------------------ RP721 ------------------------------------------------------------ aq_1308 ------------------------------------------------------------ BS_tgt ------------------------------------------------------------ BH1228 ------------------------------------------------------------ L0361 ------------------------------------------------------------ SPy0203 ------------------------------------------------------------ slr0713 ------------------------------------------------------------ DR2578 ------------------------------------------------------------ AF1485 ------------------------------------------------------------ TM1561 ------------------------------------------------------------ jhp0266 ------------------------------------------------------------ HP0281 ------------------------------------------------------------ Cj1010 ------------------------------------------------------------ CT193 ------------------------------------------------------------ CPn0219 ------------------------------------------------------------ BB0809 ------------------------------------------------------------ APE2017 YGLESLSNPRLSRFSSDAARLVEAMAEKWGGGKAVLKPLDPKPEPGQCESMVGGGEWILF MTH1877 ------------------------------------------------------------ AF0588 LRPVFGPVPAEMLETYPAGHAEIPEEDVVEEEALKAASEALMEL-------MNSHPEKRF MJ0436_1 ITTVSSSIEKPYHE-----HLNVVETDVD------------------------------- PH1116_1 --ERFGE----------------------------------------------------- PAB0740_1 --SKFGD----------------------------------------------------- MTH176_1 RLALVAPSRRPYSSSLPARIGGFS------------------------------------ VNG1959G VLPPFGPYPSALATTYPLTAETPARMDRAG---YEAAAEGVCRL-------AEANPDTAF Ta1493_1 -SNKKDTYAFTYRAWNPGYTNSEFVRDVYQKIDCNALISWSGTF-------VPAELENTY TVN1497_1 -SKKKETYVFSRKDWLPGYTNLNFVRDVYERTECNALIPWSGIM-------VPAELENTY tgt ------------------------------------------------------------ Ztgt ------------------------------------------------------------ HI0244 ------------------------------------------------------------ PM0229 ------------------------------------------------------------ VC0741 ------------------------------------------------------------ PA3823 ------------------------------------------------------------ XF0223 ------------------------------------------------------------ BU133 ------------------------------------------------------------ NMB0719 ------------------------------------------------------------ NMA0928 ------------------------------------------------------------ mll0721 ------------------------------------------------------------ CC1588 ------------------------------------------------------------ RP721 ------------------------------------------------------------ aq_1308 ------------------------------------------------------------ BS_tgt ------------------------------------------------------------ BH1228 ------------------------------------------------------------ L0361 ------------------------------------------------------------ SPy0203 ------------------------------------------------------------ slr0713 ------------------------------------------------------------ DR2578 ------------------------------------------------------------ AF1485 ------------------------------------------------------------ TM1561 ------------------------------------------------------------ jhp0266 ------------------------------------------------------------ HP0281 ------------------------------------------------------------ Cj1010 ------------------------------------------------------------ CT193 ------------------------------------------------------------ CPn0219 ------------------------------------------------------------ BB0809 ------------------------------------------------------------ APE2017 YQPFLGVFPVEACGAYPSLQIDYPQEGLPAEVIGDLASKIASTVSILRGRGFTVRLEYCG MTH1877 ------------------------------------------------------------ AF0588 KVYVSKVWMKHLQNLPPNGELNVLS--- MJ0436_1 ---------------------------- PH1116_1 ---------------------------- PAB0740_1 ---------------------------- MTH176_1 ---------------------------- VNG1959G TLAHDDWPESALEAVPQRVSLYNAVRGE Ta1493_1 PIEQTVS--SGFEPDPDF---------- TVN1497_1 PIEQTVS--SGLEPDPDV---------- tgt ---------------------------- Ztgt ---------------------------- HI0244 ---------------------------- PM0229 ---------------------------- VC0741 ---------------------------- PA3823 ---------------------------- XF0223 ---------------------------- BU133 ---------------------------- NMB0719 ---------------------------- NMA0928 ---------------------------- mll0721 ---------------------------- CC1588 ---------------------------- RP721 ---------------------------- aq_1308 ---------------------------- BS_tgt ---------------------------- BH1228 ---------------------------- L0361 ---------------------------- SPy0203 ---------------------------- slr0713 ---------------------------- DR2578 ---------------------------- AF1485 ---------------------------- TM1561 ---------------------------- jhp0266 ---------------------------- HP0281 ---------------------------- Cj1010 ---------------------------- CT193 ---------------------------- CPn0219 ---------------------------- BB0809 ---------------------------- APE2017 KVEWQARAVEALKTAAAGDLPTVEACG- MTH1877 ----------------------------