CLUSTAL W (1.74) multiple sequence alignment jhp0818 ------------------------------------------------------------ HP0886 ------------------------------------------------------------ Cj0802 ------------------------------------------------------------ CT782 ------------------------------------------------------------ CPn0932 ------------------------------------------------------------ PH0636 ------------------------------------------------------------ PAB0931 ------------------------------------------------------------ aq_1068 ------------------------------------------------------------ TM0719 ------------------------------------------------------------ AF0411 ------------------------------------------------------------ APE1592 ------------------------------------------------------------ Ta1147 ------------------------------------------------------------ TVN1244 ------------------------------------------------------------ DR1670 ------------------------------------------------------------ Rv3580c ------------------------------------------------------------ ML0323 ------------------------------------------------------------ Rv2130c ------------------------------------------------------------ ML1302 ------------------------------------------------------------ BS_cysS ------------------------------------------------------------ BH0111 ------------------------------------------------------------ L0348 ------------------------------------------------------------ SPy1941 ------------------------------------------------------------ slr0958 ------------------------------------------------------------ cysS ------------------------------------------------------------ ZcysS ------------------------------------------------------------ VC1848 ------------------------------------------------------------ HI0078 ------------------------------------------------------------ PM0945 ------------------------------------------------------------ BU487 ------------------------------------------------------------ NMB2083 ------------------------------------------------------------ NMA0347 MTTITEKRLTFAFPEDYYVTKYDEWEHYKIFQNSCNLRNKIDTNEKGKNGINQSVDDDNG PA1795 ------------------------------------------------------------ CC0460 ------------------------------------------------------------ XF0995 ------------------------------------------------------------ mlr7799 ------------------------------------------------------------ RP085 ------------------------------------------------------------ MG253 ------------------------------------------------------------ MPN356 ------------------------------------------------------------ VNG1097G ------------------------------------------------------------ UU123 ------------------------------------------------------------ TP0091 ------------------------------------------------------------ BB0599 ------------------------------------------------------------ YNL247w ------------------------------------------------------------ jhp0818 ------------------------------------------------------------ HP0886 ------------------------------------------------------------ Cj0802 ------------------------------------------------------------ CT782 ------------------------------------------------------------ CPn0932 ------------------------------------------------------------ PH0636 ------------------------------------------------------------ PAB0931 ------------------------------------------------------------ aq_1068 ------------------------------------------------------------ TM0719 ------------------------------------------------------------ AF0411 ------------------------------------------------------------ APE1592 ------------------------------------------------------------ Ta1147 ------------------------------------------------------------ TVN1244 ------------------------------------------------------------ DR1670 ------------------------------------------------------------ Rv3580c ------------------------------------------------------------ ML0323 ------------------------------------------------------------ Rv2130c ------------------------------------------------------------ ML1302 ------------------------------------------------------------ BS_cysS ------------------------------------------------------------ BH0111 ------------------------------------------------------------ L0348 ------------------------------------------------------------ SPy1941 ------------------------------------------------------------ slr0958 ------------------------------------------------------------ cysS ------------------------------------------------------------ ZcysS ------------------------------------------------------------ VC1848 ------------------------------------------------------------ HI0078 ------------------------------------------------------------ PM0945 ------------------------------------------------------------ BU487 ------------------------------------------------------------ NMB2083 ------------------------------------------------------------ NMA0347 SSGVDIIALHESTLWLIEIKDYYRLGLEPNAQSIDEKLSDLPYLIARKIRDSLAGLVSAK PA1795 ------------------------------------------------------------ CC0460 ------------------------------------------------------------ XF0995 ------------------------------------------------------------ mlr7799 ------------------------------------------------------------ RP085 ------------------------------------------------------------ MG253 ------------------------------------------------------------ MPN356 ------------------------------------------------------------ VNG1097G ------------------------------------------------------------ UU123 ------------------------------------------------------------ TP0091 ------------------------------------------------------------ BB0599 ------------------------------------------------------------ YNL247w ------------------------------------------------------------ jhp0818 ------------------------------------------------------------ HP0886 ------------------------------------------------------------ Cj0802 ------------------------------------------------------------ CT782 ------------------------------------------------------------ CPn0932 ------------------------------------------------------------ PH0636 ------------------------------------------------------------ PAB0931 ------------------------------------------------------------ aq_1068 ------------------------------------------------------------ TM0719 ------------------------------------------------------------ AF0411 ------------------------------------------------------------ APE1592 ------------------------------------------------------------ Ta1147 ------------------------------------------------------------ TVN1244 ------------------------------------------------------------ DR1670 --------------------------------------------------------MLPP Rv3580c ------------------------------------------------------------ ML0323 ------------------------------------------------------------ Rv2130c ------------------------------------------------------------ ML1302 ------------------------------------------------------------ BS_cysS ------------------------------------------------------------ BH0111 ------------------------------------------------------------ L0348 ------------------------------------------------------------ SPy1941 ------------------------------------------------------------ slr0958 ------------------------------------------------------------ cysS ------------------------------------------------------------ ZcysS ------------------------------------------------------------ VC1848 ------------------------------------------------------------ HI0078 ------------------------------------------------------------ PM0945 ------------------------------------------------------------ BU487 ------------------------------------------------------------ NMB2083 ------------------------------------------------------------ NMA0347 FKAEKQEEKDFSRLALDCNEIKIVLHIEMPSIRSKLYPSSSDLANLLKDKFKLSEFTKNF PA1795 ------------------------------------------------------------ CC0460 ------------------------------------------------------------ XF0995 ------------------------------------------------------------ mlr7799 ------------------------------------------------------------ RP085 ------------------------------------------------------------ MG253 ------------------------------------------------------------ MPN356 ------------------------------------------------------------ VNG1097G ------------------------------------------------------------ UU123 ------------------------------------------------------------ TP0091 ------------------------------------------------------------ BB0599 ------------------------------------------------------------ YNL247w ------------------------------------------------------------ jhp0818 -----------------------------------------------MFIYDTKLKQKVP HP0886 -----------------------------------------------MFIYDTKLKQKVP Cj0802 -----------------------------------------------MRLLDSVTKEKIK CT782 -------------------------MKGWIRSNSTKTRPFRMNTAMDLFLYNTLSREKER CPn0932 ---------------------------------------MAFSHIEGLYFYNTASQKKEL PH0636 ---------------------------------------------MTLRIYNTLTKQKEE PAB0931 ---------------------------------------------MGIKVYNTLTRKKEE aq_1068 ---------------------------------------------MSLRIYNTLSGKVEE TM0719 -----------------------------------------------MRITNTLTGKKEE AF0411 -----------------------------------------------MEVYNTLSRKIEK APE1592 -------------------------------------------MLVLIRVFNTLGRRKEV Ta1147 -----------------------------------------------MRFYNTLTRDVDE TVN1244 -----------------------------------------------MLIYNTLTRRLQE DR1670 NAVSSTSALPRPFPLPERGAVFLFSLRGHAMTQPTITQDTARQPNPNITLYDTMQRQKVP Rv3580c ------------------------------------MTDRAR-----LRLHDTAAGVVRD ML0323 ------------------------------------MIDSGH-----LRLHDTVAGAVRD Rv2130c ---------------------------MQSWYCPPVPVLPGR--GPQLRLYDSADRQVRP ML1302 --------------------------------------------------------MSAA BS_cysS ---------------------------------------------MTITLYNTLTRQKET BH0111 ---------------------------------------------MAIQVFNSLTRKKEP L0348 -----------------------------------------------MKIYNTYSRQLED SPy1941 ----------------------------------------------MIKIYDTMTRSLRK slr0958 ---------------------------------------------MTLRLYDSLTRAKQP cysS ----------------------------------------------MLKIFNTLTRQKEE ZcysS ----------------------------------------------MLKIFNTLTRQKEE VC1848 ----------------------------------------------MLKIYNSLTRQKEE HI0078 ----------------------------------------------MLKIFNTLTREKEI PM0945 ----------------------------------------------MLKIFNTLTREKEI BU487 ----------------------------------------------MLKIFNTLTSTKEI NMB2083 ----------------------------------------------MTTIYNTLTRQKEP NMA0347 ANCYAEPIFTNISHINNPQLRNVPWSVSTGTEQKLSSEQQRLIHNPMTTIYNTLTRQKEP PA1795 ----------------------------------------------MLQIYNTLSKTKEV CC0460 ---------------------------------------------MTLKIHDTLTREKRD XF0995 --------------------------------------MLLGWSVMSLHLYNTLHRRVEP mlr7799 ----------------------------------------MSDASQGLRLYNTLTRAKTD RP085 ---------------------------------------------MKLHLYNTLTRTKEV MG253 ------------------------------------------------MIVDSVSQKPTT MPN356 ----------------------------------------MNQFEPKFTLIDTVSNQSVV VNG1097G ---------------------------------------------MTQYVSNTRSGEQEA UU123 -----------------------------------------------MKLYDSYSNQLVE TP0091 ---------------------------------------------MALRVYNTLTRQQEH BB0599 ---------------------------------------------MILKLYNTRTKDFSE YNL247w ------------MNIFIKALRRYTIMSTPKIVQPKWKVPTPQAKETVLKLYNSLTRSKVE jhp0818 FEPLVHNK-ANIYVCGPTVYDDAHLGHARSAIAFDLLRR-TLELSGYE--VVLVRNFTDI HP0886 FEPLVQNK-ANIYVCGPTVYDDAHLGHARSAIAFDLLRR-TLELSGYE--VMLVRNFTDI Cj0802 LD---KKD-ISIYLCGPTVYDDAHLGHARSSVCFDLLRR-VLLAQGNR--VKFARNYTDI CT782 FLPVNDP--VKLYTCGPTVYDYAHIGNFRTYIFEDLLKR-VLLFLGYS--VYHVMNITDV CPn0932 FFPNHTP--VRLYTCGPTVYDYAHIGNFRTYVFEDILKR-TLVFFGYS--VTHVMNITDV PH0636 FKPINEGE-VRMYVCGPTVYDYPHLGHARTYIAFDVIRR-YLEHKGYS--VLMVMNFTDI PAB0931 LKPLRDGE-VRMYVCGPTVYDYPHLGHARTYIAFDVIRR-YLEHRGFT--VLMVMNFTDI aq_1068 FVPINPPK-VLIYTCGVTVYDDSHVGHGRSLIVFDVFRR-FLEHLGYQ--VKFVRNFTDV TM0719 FVPIQPGV-VRMYVCGPTVYDLIHVGNARPALVFDVFRR-YLEYRGYR--VIMVQNFTDI AF0411 LEDIVDGKRVKMYVCGITAYDYSHIGHARSAVFFDVFRR-YLEYLGYE--VVYVQNFTDV APE1592 FNPYSPPL-VGMYVCGPTVYDYTHIGHARTFTVFDAIKR-YLRLRGYD--VFHVQNITDI Ta1147 FKEMNSGR-INMFVCGPTVQDHFHIGHARTYIFFDAVAK-LLRNLGYS--VFYLQNITDI TVN1244 FNEMHRGR-VNLFVCGPTVQDHFHIGHARTYIFFDAVAK-FLKLEGYS--VFYLQNITDI DR1670 FVPGTPGY-VGMYLCGPTVYSDAHLGHAKKEVAFDVIRR-ALTHFGYQ--VRYVSNITDV Rv3580c FVPLRPGH-VSIYLCGATVQGLPHIGHVRSGVAFDILRR-WLLARGYD--VAFIRNVTDI ML0323 FVPLRAGH-VSIYLCGATVQGQPHIGHVRSGVAFDILRR-WLMARGYD--VAFIRNVTDI Rv2130c VAPGSK---ATMYVCGITPYDATHLGHAATYVTFDLIHR-LWLDLGHE--LHYVQNITDI ML1302 VAPTCK---ATMYVCGITPYDATHLGHAATYLAFDLIHR-LWLDLGHE--VHYVQNVTDV BS_cysS FVPLEEGK-VKMYVCGPTVYNYIHIGNARPAIVYDTVRN-YLEYKGYD--VQYVSNFTDV BH0111 FVPLEEGK-VKMYVCGPTVYNYIHIGNARPPIVYDMIRR-YLKYRGYE--VLFVSNFTDV L0348 FQPIEPGK-VKMYVCGPTVYNYIHVGNARSVVAFDLVRK-YLEFRGFE--VQYISNFTDV SPy1941 FVPLTENT-VNIYVCGPTVYNYIHIGNARSAVAFDTIRR-YFEYTGYQ--VNYISNFTDV slr0958 LQPLHPGL-VTMYCCGITVYDYCHLGHARTCITWDLVRR-YLQWSGYE--VRYVQNFTDI cysS FKPIHAGE-VGMYVCGITVYDLCHIGHGRTFVAFDVVAR-YLRFLGYK--LKYVRNITDI ZcysS FKPIHAGE-VGMYVCGITVYDLCHIGHGRTFVAFDVVAR-YLRFLGYK--LKYVRNITDI VC1848 FKPIVAGK-VGMYVCGVTIYDLCHIGHGRTFVSFDVVAR-YLRYLGYD--LTFVRNITDI HI0078 FKPIHENK-VGMYVCGVTVYDLCHIGHGRTFVCFDVIAR-YLRSLGYD--LTYVRNITDV PM0945 FKPIHANK-VGMYVCGITVYDLCHVGHGRTFVCFDVIAR-YLRYLGYD--LTYVRNITDV BU487 FTPIKKNR-VNLYVCGVTVYDFCHIGHGRTFVVFDMIVR-YLRFSGFQ--VKYVRNITDI NMB2083 FSPIDPEN-VRMYVCGMTVYDYCHLGHARVMVVFDMIAR-WLRECGYP--LTYVRNITDI NMA0347 FAPIDPKN-VRMYVCGMTVYDYCHLGHARVMVVFDMIAR-WLRECGYP--LTYVRNITDI PA1795 FTPLVGNQ-VRMYVCGMTVYDYCHLGHGRSMVAFDVITR-WLRHRGYD--LTYVRNITDI CC0460 FVPADPQR-VTMYVCGPTVYNYAHIGNFRPVVVFDVLFR-VLRHLYGEDAVVYARNVTDV XF0995 FEPLDPAC-PTMYVCGPTVYNYVHIGNARGPVVFGVLAA-LLRRRYG--ALRYARNITDV mlr7799 FVPIDALN-VRMYVCGPTVYDFAHIGNARPVIVFDVLFR-LLRHLYGQAHVTYVRNITDV RP085 FNPQDPAN-IKMYVCGPTVYDNPHIGNSRSVVVYDLLYR-IIIKIFGKKAVKYVRNITDV MG253 LV---QKT-INIYLCGPTVYNDLHLGNTRPLIVFDVLNR-VLKKAKYT--VNFVQNITDI MPN356 LE---QKQ-INIYLCGPTVYNDLHLGNTRPLIVFDVLQR-VLQAAQYK--VQFVQNITDI VNG1097G FEPDDPEN-VLVYTCGLTVSDDAHLGHARLWVQSDVMTR-WLSHAGYG--VRHVQNVTDV UU123 IN---D-ELISIYNCGPTVYNHIHIGNARPLITMDVLYR-FLKKHNIK--TKYVLNITDI TP0091 FQPWEHGH-VRLYGCGPTVYNYPHLGNLRAYVFQDTVRR-TLHFLGYR--VTYVMNITDV BB0599 LTNFEN---VKVYACGPTVYNYAHIGNFRTYIFGDLLIK-TLRFLGYK--VNYAMNITDI YNL247w FIPQSGNRGVTWYSCGPTVYDASHMGHARNYVSIDINRRIIQDYFGYD--VQFVQNVTDI . : ** * . *:*: . * **: jhp0818 ----------DDKIINKAF-------------------------------------KENK HP0886 ----------DDKIINKAL-------------------------------------KENK Cj0802 ----------DDKILKKMA-------------------------------------QSGQ CT782 ----------DDKTLAGAR-------------------------------------KKGC CPn0932 ----------EDKTIAGAS-------------------------------------KKNI PH0636 ----------DDKIIRRAK-------------------------------------ETGE PAB0931 ----------DDKIIKRAQ-------------------------------------ETGE aq_1068 ----------DDKIINRAK-------------------------------------QECT TM0719 ----------DDKIINKAN-------------------------------------QLGV AF0411 ----------DDKIINRAV-------------------------------------KEGK APE1592 ----------DDKIINRAR-------------------------------------EEGR Ta1147 ----------DDKIINKAR-------------------------------------EMNI TVN1244 ----------DDKIINRAK-------------------------------------EMGI DR1670 GHLLNDADEGEDKLQARAR-------------------------------------LEQL Rv3580c ----------EDKILAKAA-------------------------------------AAGR ML0323 ----------DDKILNKAA-------------------------------------AAGR Rv2130c ----------DDPLFERAD-------------------------------------RDGV ML1302 ----------DDPLFERAD-------------------------------------RNGV BS_cysS ----------DDKLIKAAN-------------------------------------ELGE BH0111 ----------DDKIIRVAN-------------------------------------ELGE L0348 ----------DDKIINGAK-------------------------------------AANM SPy1941 ----------DDKIIKAAT-------------------------------------QAGV slr0958 ----------DDKILKRAV-------------------------------------DESS cysS ----------DDKIIKRAN-------------------------------------ENGE ZcysS ----------DDKIIKRAN-------------------------------------ENGE VC1848 ----------DDKIIKRAA-------------------------------------ENAE HI0078 ----------DDKIIKRAL-------------------------------------ENKE PM0945 ----------DDKIIKRAL-------------------------------------ENNE BU487 ----------DDKIISKST-------------------------------------KEKK NMB2083 ----------DDKIIARAA-------------------------------------ENGE NMA0347 ----------DDKIIARAA-------------------------------------ENGE PA1795 ----------DDKIINRAN-------------------------------------ENGE CC0460 ----------DDKINQKAA-------------------------------------DEGV XF0995 ----------DDKINTAAQ-------------------------------------EQGV mlr7799 ----------DDKINARALR------------------------------------DFGS RP085 ----------DDKIIDRAE-------------------------------------LLGI MG253 ----------DDKIIKIAQ-------------------------------------QQEV MPN356 ----------DDKIIKIAQ-------------------------------------QQEI VNG1097G ----------NEKIVARVG-------------------------------------ADGL UU123 ----------DDKIINYALA------------------------------------NNLK TP0091 GHLESDADSGEDKLVRSAQ-------------------------------------AHGH BB0599 GHLTGDLDDGEDKVAKTAR-------------------------------------EKGL YNL247w ----------DDKIILRARQNYLFDNFVKENDTKFNATVVDKVKTALFQYINKNFTIQGS :: jhp0818 SIQE-------------------------------------------------------- HP0886 SIQE-------------------------------------------------------- Cj0802 TLEE-------------------------------------------------------- CT782 SLEK-------------------------------------------------------- CPn0932 PLQE-------------------------------------------------------- PH0636 DPAK-------------------------------------------------------- PAB0931 DPGK-------------------------------------------------------- aq_1068 DFMT-------------------------------------------------------- TM0719 DYKT-------------------------------------------------------- AF0411 TQKE-------------------------------------------------------- APE1592 DWRE-------------------------------------------------------- Ta1147 QPQD-------------------------------------------------------- TVN1244 EPSE-------------------------------------------------------- DR1670 EPME-------------------------------------------------------- Rv3580c PWWE-------------------------------------------------------- ML0323 PWWE-------------------------------------------------------- Rv2130c DWRD-------------------------------------------------------- ML1302 DWRD-------------------------------------------------------- BS_cysS DVPT-------------------------------------------------------- BH0111 DVFA-------------------------------------------------------- L0348 TTTD-------------------------------------------------------- SPy1941 SPKE-------------------------------------------------------- slr0958 TMEA-------------------------------------------------------- cysS SFVA-------------------------------------------------------- ZcysS SFVA-------------------------------------------------------- VC1848 TCES-------------------------------------------------------- HI0078 TCDQ-------------------------------------------------------- PM0945 TCNQ-------------------------------------------------------- BU487 KINT-------------------------------------------------------- NMB2083 TIGK-------------------------------------------------------- NMA0347 TIGE-------------------------------------------------------- PA1795 PFDV-------------------------------------------------------- CC0460 PISV-------------------------------------------------------- XF0995 PISA-------------------------------------------------------- mlr7799 EISAGKLSLNEAI----------------------------------------------- RP085 TIND-------------------------------------------------------- MG253 SESV-------------------------------------------------------- MPN356 SEAQ-------------------------------------------------------- VNG1097G GDTEAA------------------------------------------------------ UU123 ELE--------------------------------------------------------- TP0091 SVLQ-------------------------------------------------------- BB0599 TVYE-------------------------------------------------------- YNL247w EIKTIEEFETWLSNADTETLKLENPKFPMHVTAVQNAIESITKGDSMDAEVAFEKVKDVT jhp0818 --------------------LSSIYIESYTRDLNALNVKQPSLEPKASEYLD-------A HP0886 --------------------LSSIYIESYTRDLNALNVKKPSLEPKASEYLD-------A Cj0802 --------------------ITEFYIKSYEEDMRVLNVLDPDFKPRATHYIT-------A CT782 --------------------YCQPYIHAFFADLETLHILKADAYPHATHYIP-------Q CPn0932 --------------------YTQPYTEAFFEDLDTLNIARADFYPHATHYIP-------Q PH0636 --------------------LAEKFIKVFLEDMKALKVKPADIYPRVTEHIE-------D PAB0931 --------------------LAERFIKVFLEDMNALKVKPADIYPRVTEHID-------D aq_1068 --------------------IADRYIARYYVDMENIRVRPADVEPRVTEHIP-------E TM0719 --------------------VADTFIAEYWRDAHALGIRPANFHPRTTDFVE-------D AF0411 --------------------VAEKFIEEYLKDMEALNVKKPTYQPKVTEHIP-------D APE1592 --------------------IVREYSRDYLEGLGSLGIQ-IDHHPRVTDHIS-------D Ta1147 --------------------VADMYLREFLEDMSALKVTSVNYFAKSTLYIN-------E TVN1244 --------------------VAKIYFSEFQEDMKRLKVDSVNFFARATLYID-------E DR1670 --------------------VADKYFWSFFRDMDALNVLRPSINPRATGHIQ-------E Rv3580c --------------------WAATHERAFTAAYDALDVLPPSAEPRATGHIT-------Q ML0323 --------------------WAATHERAFTAAYDALDVLPPSAEPRATGHIT-------Q Rv2130c --------------------LAQAEVALFCEDMAALRVLPPQDYVGATEAIA-------E ML1302 --------------------LAEREVALFRDDMASLRILPPHDYVAATETIV-------E BS_cysS --------------------ISERFIKAYFEDVGALGCRKADLHPRVMENMD-------A BH0111 --------------------VANRFIEAYKQDTSALGVLEADHHPRVTETMS-------E L0348 --------------------FSERYIAAFYEDTDALNVKRASQNPKATEFIE-------A SPy1941 --------------------LSDRFIAAFIEDTKALGVKPATQNPRVMDYIA-------E slr0958 --------------------VSEKFIAAYFEDMEALGVQPADLYPRATHTLD-------G cysS --------------------MVDRMIAEMHKDFDALNILRPDMEPRATHHIA-------E ZcysS --------------------LVDRMIAEMHKDFDALNILRPDMEPRATHHIA-------E VC1848 --------------------LTERLIQEMYADFDALNIKRPDVEPRATAYIE-------E HI0078 --------------------LVDRMVQEMYKDFDALNVLRPDFEPRATHHIP-------E PM0945 --------------------LVEKMIAEMHKDFDALNVLRPDVEPRATHHIP-------E BU487 --------------------FTASMIKEMHKDFDLLGISVPDEEPRVTDYID-------N NMB2083 --------------------LTARFIQAMHEDADALGVLRPDIEPKATENIP-------Q NMA0347 --------------------LTARFIQAMHEDADALGVLRPDIEPKATENIP-------Q PA1795 --------------------LTERMIAAMHEDEARLNILKPDQEPRATDHIA-------G CC0460 --------------------ITDRYLAAYHQDADALGALRPTLEPKATEHIG-------A XF0995 --------------------ITERFCAAYREDMKKLGVEPPDIEPEATAHMP-------Q mlr7799 ------------------RRVTEKTADQFHRDVATLGCLEPTVEPRATEFVEPRADGKAD RP085 --------------------LTDKVTREFHINMEYLGCMLPTIEPKATEHID-------V MG253 --------------------VTKQQITAYKSLLKKLNIL-PIKHIQITEKID-------K MPN356 --------------------LCKQQITAYKSLLKKLNIL-PIKHLQVTDKID-------K VNG1097G --------------------VAAHYTQSVIDDMRALNLARADVYPRVSEHVP-------E UU123 --------------------VSEYYFNEYLKIKKALNTL-EMINPKVSTHMD-------K TP0091 --------------------VAAHYRAAFFRDTALLGIEEPSIVCNASDCIQ-------D BB0599 --------------------ISEFFTEAFFNDCRKLNIVYPDKVLVASKHIP-------I YNL247w VPLLDKELGSTISNPEIFRQLPAYWEQKFNDDMLSLNVLPPTVTTRVSEYVP-------E : : jhp0818 MVRMIETLLEKNFAYRVSNGD-----IYLDTSKDK-----DYGSLSMHNSSVEFS----- HP0886 MVGMIETLLEKNIAYQVSNGD-----IYLDTSKDK-----DYGSLSVHNSSIEFG----- Cj0802 MLDLIKKLAKDGFVYTLEDG------IYFDTSKDE-----KYLSLSNRNLEENIS----- CT782 MIEAIQQLINQGVAYIGQDQ-----SVYFSISQFP-----NYGALSHLNLEELRNS---- CPn0932 MIQAITKLLEQGIAYIGQDA-----SVYFSLNRFP-----NYGKLSHLDLSSLRCC---- PH0636 IIQFIERLKEKGYAYEGSDG------VYFEVQKFK-----EYGKLSGVKLEELRKG---- PAB0931 IIEFIKKLKEKGYAYEGSDG------VYFEVQKFK-----DYGKLSGVKIEELRKG---- aq_1068 IIEVIQKLVEKGYAYVVEGD------VYFSVKKFK-----DYGKLSKRDIEELIAG---- TM0719 IVEIIEKLVEKGFAYQTETG------VYFDVRKFE-----KYGELSKKKIEDLIAG---- AF0411 IIEFIQNLIEKGYAYVIDGD------VYFHVPAFE-----HYGELSKQSLEELNR----- APE1592 IIRFIEGLIEKGYAYVAESGS-----VYFEVDKYP-----GYGMLSGHLSKEAWR----- Ta1147 IISQISRLIEKGYAYETSDG------VYFEVSKFA-----DYGQLSNQSLDQIIHG---- TVN1244 IVSQISRMMEKGYAYETDDG------VYFEVRKFK-----DYGELSNQSLDQIIAG---- DR1670 QIKLIEELIEKGHAYESA------GSVYFDVRSWP-----EYGKLSGRKLDDQEEGTR-- Rv3580c MIEMIERLIQAGHAYTGG------GDVYFDVLSYP-----EYGQLSGHKIDDVHQG---- ML0323 MIELIELLIETGHAYTGG------SDVYFDVLSYP-----DYGQLSGHKMDYIHQG---- Rv2130c MVELIEKMLACGAAYVIDREMGEYQDIYFRADATL-----QFGYESGYDRDTMLRLCEER ML1302 IVELVDKMLVSGAAYVID---DEYPDIYFRADATL-----QFGYESGYDRDTMLRLYEQS BS_cysS IIEFVDQLVKKGYAYESEG------DVYFKTRAFE-----GYGKLSQQSIDELRSG---- BH0111 IISFIRVLEEKGYAYEQGG------DVYFRTRKFK-----EYGKLSAQSIDDLLSG---- L0348 MIEFIQELVDKEFAYVSQG------DVYFRVSKSK-----DYAKLANKNLADLLAG---- SPy1941 IISFVESLIEKDFAYEADG------DVYFRVEKSE-----HYAKLANKTLSELEVG---- slr0958 IKRLIAELEAKGYAYPSGG------DVYYSVRNFD-----GYGKLSGRRLEDLQAG---- cysS IIELTEQLIAKGHAYVADNG-----DVMFDVPTDP-----TYGVLSRQDLDQLQAG---- ZcysS IIELTEQLIAKGHAYVADNG-----DVMFDVPTDP-----TYGVLSRQDLDQLQAG---- VC1848 IIALVERLIERGFAYVADNG-----DVMFEVSQYS-----EYGKLSKQDLDQLQAG---- HI0078 IIEIVEKLIKRGHAYVADNG-----DVMFDVESFK-----EYGKLSRQDLEQLQAG---- PM0945 IIAMIEKLIARQHAYVSANG-----DVMFDVESFK-----EYGKLSRQNLEQLQAG---- BU487 IIRIITTLIKKKHAYIHKNG-----DVIFSIDSDP-----NYGTLSRQSLTSLESG---- NMB2083 MIAMIETLIQNGKAYPAANG-----DVYYAVREFA-----AYGQLSGKSLDDLRAG---- NMA0347 MIAMIETLIQNGKAYPAANG-----DVYYAVREFS-----AYGQLSGKSLDDLRAG---- PA1795 MHAMIQTLIDKGYAYAPGNG-----DVYYRVGKFA-----GYGKLSRRRVEDLRIG---- CC0460 ILEMIGQLVENGSAYAAEG------HVLFDTQSFA-----DYGQLSGRPLDEMIAG---- XF0995 IIAMIEQLIERQHAYVAME------HVLFAVNSFA-----DYGQLSRRDPEEMLAG---- mlr7799 MITLIQSLIKRGHAYAAAG------EVLFDTASMP-----DYGQLSKRNLDEQQAG---- RP085 MIEIIERLIAKDHAYIADN------HVYFDVLSAP-----NYTELSNRNLEAMFEG---- MG253 IPDYIDQLVNQNHAYVSTQN-----NVYFAVNSLK-----QYGYLANRMVH-LEET---- MPN356 MPGYIARLVKKGFAYVSPLG-----NTYFSVSQLP-----QYGILANRVVETIEDE---- VNG1097G IIDLIGDLVDAGYAYEAGGS------VYFDVRRFE-----EYGALSGQQVDELDPQ---- UU123 IIDYIQKLIDKQAGYFIGD------DVYFDTKKAL-----NYGQLSKRDLENDIVG---- TP0091 MIAFIEQLLARGHAYCAGGN------VYFDVRSFP-----SYESFGSAAVEDVQEGED-A BB0599 MIEVVKILEEKKITYFSNGN------VYFDTSCFK-----SYGEMAGIDLIDKDMT---L YNL247w IIDFVQKIIDNGYAYATSDG-----SVYFDTLKFDKSPNHDYAKCQPWNKGQLDLINDGE : * : jhp0818 -RIGLVQE------KRLEQDFVLWKS--YKGDNDVG----------------FDSPLGKG HP0886 -RIGLVQE------KRLEQDFVLWKS--YKGDNDVG----------------FDSPLGKG Cj0802 -RLSNEVQ------KRNESDFVLWK---FDEN--F-----------------YESEFGKG CT782 ARIDADEYD-----KDNLCDFVLWKA--YDPDRDG--------------EIFWESPFGKG CPn0932 SRISADEYD-----KENPSDFVLWKA--YNPERDG--------------VIYWESPFGKG PH0636 ARVEPGEG------KKNPEDFALWKK--AKPG-----------------EPKWESPWGEG PAB0931 ARVEPGEG------KKNPEDFALWKK--AKPG-----------------EPKWDSPWGEG aq_1068 ARVEPSEK------KRDPLDFALWKA--SKAG-----------------EPAWDSPWGKG TM0719 ARVEVDET------KKSPLDFSLWKK--AKPG-----------------EPCWKSPWGEG AF0411 HRIEPDER------KRDVKDFALWKS--AKEADLK-A------------QAVFDSPWGRG APE1592 QEEDVLHE------KKSPYDFALWKA--AKPG-----------------EPSWESPWGRG Ta1147 YRVAVNEN------KRNPEDFVLWKK--RKPG-----------------EPYWDSPWGPG TVN1244 YRVAVNEN------KRNPEDFVLWKK--KKAG-----------------EPSWPSPWGEG DR1670 --EAVRDE------KRDPRDFALWKK--AEPEHLMR----------------WDSPWSVG Rv3580c --EGVAAG------KRDQRDFTLWKG--EKPGEPS-----------------WPTPWGRG ML0323 --EGVTTG------KRDQRDFTLWKG--AKSGEPS-----------------WPTPWGRG Rv2130c GGDPRRPG------KSDELDALLWRA--ARPGEPS-----------------WPSPFGPG ML1302 GGDPRRPG------KNGELDALLWRA--ARPGEPS-----------------WSSPFGPG BS_cysS ARIRVGEK------KEDALDFALWKA--AKEGEIS-----------------WDSPWGKG BH0111 ARIEVDER------KEDPLDFVLWKA--AKEGEVS-----------------WDSPWGKG L0348 ASGRTDEET---KLKESPADFALWKS--AKADEVS-----------------WQAPWGAG SPy1941 ASGRTDAET---ALKENPLDFALWKS--AKAGEVS-----------------WDSPWGFG slr0958 ASGRVTVADPDGAQKQDPFDFALWKS--AKPGEPA-----------------WESPWGKG cysS ARVDVVDD------KRNPMDFVLWKM--SKEGEPS-----------------WPSPWGAG ZcysS ARVDVVDD------KRNPMDFVLWKM--SKEGEPS-----------------WPSPWGAG VC1848 ARVDIEAA------KRSPLDFVLWKM--SKPGEPT-----------------WESPWGSG HI0078 ARIEINEI------KKNPMDFVLWKM--SKENEPS-----------------WASPWGAG PM0945 ARVEIVNV------KKNPMDFVLWKM--SKPGEPS-----------------WPSPWGEG BU487 SRIPLNNM------KKNPLDFILWKS--SNKEEYS-----------------WDSPWGKG NMB2083 ERVEVDGF------KRDPLDFVLWKA--AKAGEPA-----------------WESPWGNG NMA0347 ERVEVDGF------KRDPLDFVLWKA--AKAGEPA-----------------WESPWGNG PA1795 ARIEPGEA------KEDPLDFVLWKG--AKPGEPS-----------------WSSPWGEG CC0460 ARVEVAPY------KRHPADFVLWKP--SKENEPE-----------------WESPWGAG XF0995 ARVEIAPY------KRDPSDFVLWKP--SSDQLPG-----------------WDSPWGRG mlr7799 ARVAVDAH------KKNPGDFVLWKL--SSPEEPG-----------------WQSPWGRG RP085 VRIENSKT------KKNPQDFVLWKP--AKKNEPEN--------------INFTSPWGLG MG253 ------DTD-----KKNKLDFVLWKI--TTAGIK------------------WNSKWGLG MPN356 ------ATD-----KRNKLDFVLWKQ--TTAGVK------------------WNSPWGWG VNG1097G ---GPDAEQA---EKRHPADFALWKAGGVSPDDANTHRDDELPPLDGERGQTWASPWGEG UU123 MRIESAAN------KHNPNDFILWKK--TNKG------------------IMWNTPWGIG TP0091 ARARVAHDT----HKRDARDFVLWFTR-SKFVRHALT---------------WDSPWGRG BB0599 PRVDVDKF------KRNKTDFVLWFTN-SKFKDQE---------------MKWDSPWGFG YNL247w GSLSNFADNG----KKSNNDFALWKA--SKAGEPE-----------------WESPWGKG * * ** : : . * jhp0818 RPGWHIECSSMVFETLALANAPYQIDIHAGGTDLLFPHHENEACQTRCAFG--------- HP0886 RPGWHIECSSMVFETLALTNTPYQIDIHAGGADLLFPHHENEACQTRCAFG--------- Cj0802 RPGWHTECVAMIDSIFENT-----LDIHAGGIDLLFPHHENEAAQCRCGCK--------- CT782 RPGWHLECSIMSISLLGQS-----LDIHAGGVDNIFPHHENEIAQSESLSH--------- CPn0932 RPGWHLECSIMAMELLGDS-----LDIHAGGVDNIFPHHENEIAQSEALSG--------- PH0636 RPGWHIECSVMSSKYLGES-----FDIHGGGNDLIFPHHENEIAQSEACFG--------- PAB0931 RPGWHIECSVMSSKYLGES-----FDIHGGGNDLIFPHHENEIAQSEACFG--------- aq_1068 RPGWHTECVAMVFKHLGET-----IDIHGGGLDLVFPHHENEIAQAEAITG--------- TM0719 RPGWHIECTVMSVKILGES-----FDIHAGGEDLVFPHHENEKAQAEALTG--------- AF0411 RPGWHIECSVMSAKYLGVP-----FDIHGGGKDLIFPHHENERAQSFARFG--------- APE1592 RPGWHIECSVMSSRYLGSR-----IDIHGGGVDLVFPHHENERAQSESYFG--------- Ta1147 RPGWHIEDTAITETYFGPE-----YDIHGGGSDLIFPHHEAEIAQMRAISGR-------- TVN1244 RPGWHIEDTAITETYFGDE-----YDIHGGGSDLIFPHHEAEIAQMRSISGK-------- DR1670 FPGWHIECSAMSLKYLGEG-----FDIHGGGLDLQFPHHEAEIAQAEAAG---------- Rv3580c RPGWHLECSAMARSYLGPE-----FDIHCGGMDLVFPHHENEIAQSRAAG---------- ML0323 RPGWHLECSAMARAYLGSE-----FDIHCGGMDLVFPHHENEIAQSRAVG---------- Rv2130c RPGWHVECAAIALSRIGSG-----LDIQGGGSDLIFPHHEFTAAHAECVSGE-------- ML1302 RPGWHVECAAIALSRIGIG-----LDIQGGGSDLIFPHHEFTAAHAECVRGE-------- BS_cysS RPGWHIECSAMVKKYLGDQ-----IDIHAGGQDLTFPHHENEIAQSEALTG--------- BH0111 RPGWHIECSAMVKKYLGDT-----IDIHAGGQDLKFPHHENEIAQSECMTG--------- L0348 RPGWHIECSVMSTSLLGET-----IDIHGGGADLEFPHHTNEIAQSEAKTG--------- SPy1941 RPGWHIECSVMATEILGDT-----IDIHGGGADLEFPHHTNEIAQSEAKTG--------- slr0958 RPGWHIECSAMVREFLGET-----IDLHVGGNDLIFPHHENEIAQSEAVTG--------- cysS RPGWHIECSAMNCKQLGNH-----FDIHGGGSDLMFPHHENEIAQSTCAHD--------- ZcysS RPGWHIECSAMNCKQLGNH-----FDIHGGGSDLMFPHHENEIAQSTCAHD--------- VC1848 RPGWHIECSAMNSSILGTH-----FDIHGGGSDLQFPHHENEIAQSCCAHD--------- HI0078 RPGWHIECSAMNCKQLGEY-----FDIHGGGSDLMFPHHENEIAQSCCAHG--------- PM0945 RPGWHIECSAMNHKELGEH-----FDIHGGGSDLTFPHHENEIAQSCCAHS--------- BU487 RPGWHIECSAITNVFFNNS-----IDIHGGGSDLLFPHHENERSQSICFNN--------- NMB2083 RPGWHIECSAMSENLFGDT-----FDIHGGGADLQFPHHENEIAQSVGATGHTCGHHHAQ NMA0347 RPGWHIECSAMSENLFGNT-----FDIHGGGADLQFPHHENEIAQSVGATGHTCGHHHAQ PA1795 RPGWHIECSVMSTCCLGDS-----FDIHGGGNDLEFPHHENEIAQSEAATG--------K CC0460 RPGWHIECSAMIDKALGQT-----IDIHAGGIDLTFPHHENEVAQSRCAHK--------- XF0995 RPGWHIECSAMAAAHLGET-----IDIHAGGIDLQFPHHENEIAQSRCAHG--------- mlr7799 RPGWHIECSAMSAAYLGEV-----FDIHGGGLDLIFPHHENEIAQSRCAHG--------- RP085 RPGWHIECSAMSYKYLGQN-----FDIHGGGADLIFPHHTNEIAQSRCAFP--------- MG253 RPGWHVECAFLIDYCFKNE-----LTIHGGGVDLKFPHHENENALHMALYN--------- MPN356 RPGWHVECAFLIDYSFKDQ-----LTIHGGGVDLKFPHHENENAMHMALYD--------- VNG1097G RPGWHIECSAMAMTHLDDH-----IDIHVGGQDLVFPHHENEIAQSEAASG--------- UU123 RPGWHSECSCLINTYIGEQ-----VSIHGGGIDLKFPHHENENAQNQVLYN--------- TP0091 YPGWHIGCSAMSMKFLGPR-----CDIHIGGVDHIRVHHRNERAQCEAITG--------- BB0599 YPSWHLECAAMNLEYFKDA-----LDIHLGGVDHIGVHHINEIAIAECFLN--------- YNL247w RPGWHIECSVMASDILGSN-----IDIHSGGIDLAFPHHDNELAQSEARFDN-------- *.** : : :: ** * ** . jhp0818 -------VEIAKYWMHNGFVNINNEK-----------------MSKSLGNSFFIKDALKN HP0886 -------VELAKYWMHNGFVNINNEK-----------------MSKSLGNSFFVKDALKN Cj0802 -------RKLANIWLHNGFVKIDGEK-----------------MSKSLNNSFFIKDALKE CT782 -------KPFVRYWLHSHHLLVDRKK-----------------MSKSLGNFFTLRDLLDQ CPn0932 -------KPFARYWLHSEHLLIDGKK-----------------MSKSLGNFLTLRDLLHQ PH0636 -------HEWVHYWLHTGFVMVKGEK-----------------MSKSLGNFVTVRELLQR PAB0931 -------HEWVRYWLHTGFVMVKGEK-----------------MSKSLGNFVTVRELLQR aq_1068 -------KPFARYWMHNGLVTVGGQK-----------------MSKSLGNYVTLREVYTK TM0719 -------KVFARYWMHNGMVRFLGDK-----------------MSKSTGNIFTVREAVKR AF0411 -------VEPVKIWVHNDFIRIKGEK-----------------MSKSLGNIVRIRDVLQR APE1592 -------HRWVRYWLHASYLTIKGEK-----------------MSKSLGNIIPLREALRE Ta1147 -------KYLSHYWIHTGMINVNNEK-----------------MSKSLKNFVTIREVLKE TVN1244 -------RYLAHYWIHTGMININKEK-----------------MSKSLKNFITIRDILKD DR1670 -------HHFARYWMHNNMLTIGGEK-----------------MSKSKGNFTTIQDILKK Rv3580c -------DGFARYWLHNGWVTMGGEK-----------------MSKSLGNVLSMPAMLQR ML0323 -------DGFARYWLHNGWVTMGGEK-----------------MSKSLGNVLSIPAVLQR Rv2130c -------RRFARHYVHAGMIGWDGHK-----------------MSKSRGNLVLVSALRAQ ML1302 -------RRFARHYVHAGMIGWDEHK-----------------MSKSRGNLVLVSTLRAQ BS_cysS -------KTFAKYWLHNGYINIDNEK-----------------MSKSLGNFVLVHDIIKQ BH0111 -------KPMANYWLHNGFINLDNEK-----------------MSKSLGNVVLANEMIRQ L0348 -------QKFVNYWMHNGFVNVDGEK-----------------MSKSLGNFTTVHELLQV SPy1941 -------KTFANYWMHNGFVTVDNEK-----------------MSKSLGNFVTVHDMLQT slr0958 -------QPLAQYWLHNGMVKVDGEK-----------------MSKSLGNFTTIRALLKT cysS -------GQYVNYWMHSGMVMVDREK-----------------MSKSLGNFFTVRDVLKY ZcysS -------GQYVNYWMHSGMVMVDREK-----------------MSKSLGNFFTVRDVLKY VC1848 -------TQYVNTWMHSGMVMVDKEK-----------------MSKSLGNFFTIRDVLGH HI0078 -------GQYVNYWIHSGMIMVDKEK-----------------MSKSLGNFFTIRDVLNH PM0945 -------GRYVNYWIHSGMIMVDREK-----------------MSKSLGNFFTLREVLSL BU487 -------KSMINFWMHTGMVILNNKK-----------------MSKSLGNVYFLRNILKD NMB2083 THHGQSIASHVKYWLHNGFIRVDGEK-----------------MSKSLGNFFTIREVLKQ NMA0347 THHGQSIASHVKYWLHNGFIRVDGEK-----------------MSKSLGNFFTIREVLKQ PA1795 PYA-------KS-WLHCGMITINGEK-----------------MSKSLGNFFTIREVLEK CC0460 ------TSVLANYWMHNGFLDMSGEK-----------------MSKSLGNVIIPHELLET XF0995 ------SSTFARVWMHNGMLNFEGAK-----------------MSKSLGNIETVHGLVAK mlr7799 ------TSVMANVWMHNGFLQVEGQK-----------------MSKSLGNFYSIHELLET RP085 ------SSTYAKYWIHNGFLTVNGSK-----------------MSKSLGNFITVRDLMDK MG253 -------QPITKHWMHIGHLMIENQK-----------------MSKSLQNFLLAVDFLNF MPN356 -------KPLTQHWMHIGHLMFENQK-----------------MSKSLQNFLLAVDFLTI VNG1097G -------ERFADHWLHVRLLETDGEK-----------------MSSSLGNFFTVSNAVAE UU123 -------KNLAKVWMHFGLVNINNEK-----------------MSKSLNNFILVKDLLAE TP0091 -------APWVRYWLHHEFLLMQLQKRAVHADMGSSVVSSFSKMSKSCGQFLTLSSLQER BB0599 -------KKWCDVFVHGEFLIMDYNK-----------------MSKSRGNFITVKDLEDQ YNL247w -------QQWINYFLHTGHLHIEGQK-----------------MSKSLKNFITIQEALKK ::* : * **.* : jhp0818 Y-------DGEILRNYLLGVHYRSVLNFNEEDLLMSKKRLDKIYRLKQRV-LGTLG---- HP0886 Y-------DGEILRNYLLGVHYRSVLNFNEEDLLVSKKRLDKIYRLKQRV-LGTLG---- Cj0802 F-------MGEALRFYLLSSHYRSHFNYSLSDLENAKKRLDKFYRLKKRLDLGEISDFDV CT782 G------FSGEEVRYLLLQGHYRTQLNFTQEGLHASRQSLKRLRDFICRLEDPSYPDDII CPn0932 E------FTGQEVRYMLLQSHYRTQLNFTEEALLACRHALRRLKDFVSRLEGVDLPGESP PH0636 -------YSPEVIRFFVLQKHYRSPLDYSEEGLQHAKNNLERLYNTLENIRIAMENAELA PAB0931 -------YSPEVIRLFVLQKHYRSPLDYTEEGLQHAKNNLERLYNTLENIRIAMRNAELS aq_1068 -------YHPDVLRLLVLFTHYRSPLDFSWEKMEETLKAYERLKNAIEDLELLKK-LQVV TM0719 -------YGRDGLRYMILSKHYRSPMDFSEELLQDYSRAVKRVWEILGRYE--------- AF0411 -------YEGEVLRYFLLTAHYRSPLDYTEEALERAKRAYEYLRSALINLD-----MEIA APE1592 -------WGPGPLRLWLLSSHYRSNLDYSEEALGQYRRLYERLRQAADSIG--RRLERAE Ta1147 -------YRPEDLRYALLNANYRTQLDFSKGLLEESRKQVEYLNSTFRKLV--------- TVN1244 -------YRPEDLRFAILNANYRTQIEFSKELMEESKKLIDYINDTYRKLE--------- DR1670 -------YDPMVVRFLLVSSHYRSVTEMNEEAFASAANGYRRLSETLHEIERRLK----- Rv3580c -------VRPAELRYYLGSAHYRSMLEFSETAMQDAVKAYVGLEDFLHRVRTRVG----- ML0323 -------VRPAELRYYLGSAHYRSMLEFSEAALQDAVKAYVGVENFLTRVRTRVG----- Rv2130c D------VEPSAVRLGLLAGHYRADRFWSQQVLDEATARLHRWR-----TATALP----- ML1302 G------APPSAIRLGLLAGHYRADRFWSSQLLDDAIARLHRWR-----TAASMP----- BS_cysS H-------DPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSSTNL BH0111 H-------SAEVLRFFMLSAHYRSPINFSDELLEGAKRGLERLQTAVSSLVHRLQESADF L0348 V-------NPQILRFFLATTHYRRPVNFTDDALTEAENNIKKIENAYRH----LDEQAES SPy1941 V-------DGQVLRFFLATQQYRKPINFTEKTIHDAEINLKYLKNTLQQP---LTETADE slr0958 V-------DPMAIRLLVLQGHYRKPLDFTETAIAAATNGWHTLREGLQFG---YDYGGDF cysS Y-------DAETVRYFLMSGHYRSQLNYSEENLKQARAALERLYTALRGTDKTVAPAGG- ZcysS Y-------DAETVRYFLMSGHYRSQLNYSEENLKQARAALERLYTALRGTDKTVAPAGG- VC1848 Y-------DAETVRYFLMSGHYRSQLNYSEENLNQARASLERLYNALRGLDRSVPAAGG- HI0078 Y-------NAEAVRYFLLTAHYRSQLNYSEENLNLAQGALERLYTALRGTDQSAVAFGG- PM0945 Y-------DAESVRYFLLTAHYRSQLNYSEENLNLAHSALERLYTALRGTDPTAVATEG- BU487 C-------DAEVLRYFFLSTHYRHPIYYCEKNLDQAYTSLKYLYTALYDTNPFFNNEEG- NMB2083 Y-------DPEVVRFFILRAHYRSPLNYSDAHLDDAKGALTRLYTTLKNTPPADPMPSEA NMA0347 Y-------DPEVVRFFILRAHYRSPLNYSDAHLDDAKGALTRLYTTLKNTPAAEFDLSEN PA1795 Y-------HPEVVRYLLIASHYRSPINYSEENLREAKAALDRFYNALKGLPEAAPAEAA- CC0460 T-------PGEVIRWALLSAHYRQPLDWTPELLEQSKKSLDRLYGALRRAKDVAPDQAM- XF0995 H-------PPEALRYALLSAHYRKPLDWSEALIAQSVRTLNRLYGTLR---DLAAYPAHP mlr7799 ETFGGRSWPGEVLRLAMLMTHYREPIDFSVRKLEEAENTLRKWKRAAD----LAPAAGQ- RP085 Q------IQGEVVRLFLLSSHYRRPLDYNDKAIDDAKKTLDYWYRAIEH---INVQKVD- MG253 H-------DFRVLRWIFYQKHYLHPIDLNQSLIEKANNDIQRIAKTLNVARTWLVYSEQ- MPN356 H-------DFRILRWLFYQKHYYHPLDLSQSLIEQACSDIKRIQKAVNVCRTWFVYSEQ- VNG1097G R-------GPNVVRMLLVSTSYTQRQTYSEATVSEATQRWERLQRAHERAADAIDSVAAH UU123 Y-------DYQVVRWFFYQADYKQPIKFSHEIMKQNEKEILKIKNAIYNAKNYLYFNNQL TP0091 G------FQPADFRFFLLSGQYRTQLAFSWDALKTARAARRSFVRRVARVVDAARATTGS BB0599 N------FSPLDFRYLCLTSHYRNQLKFSLDNLQASKIARENLINKLSYFYESLDPVDLN YNL247w F-------SPRQLRLAFASVQWNNQLDFKESLIHEVKSFENSMNNFFKTIRALKNDAASA .* : . jhp0818 ------------------GINPNFKKEILECMQDDLNVS--------KALSVLESMLSST HP0886 ------------------GINPNFKKEILECMQDDLNVS--------KALSVLESMLSST Cj0802 ------LNDI--------GIKSEIAKQILEILNDDLNVS--------KALALLDDFISSA CT782 HPEVATAC-------------QSFLETFITSLTNDLNIS--------SSLAALFDFIRKI CPn0932 LPRTLDSS-------------SQFIEAFSRALANDLNVS--------TGFASLFDFVHEI PH0636 YTWDENDFKA-------YNSIKEARRKFYEAMDDDFNTA--------EALKAVFEVSNAI PAB0931 YKWSEKDFEA-------YEAIREARKKFYDAMDDDFNTA--------EALKAVFEVSNAI aq_1068 ESKEGGTHPL-------YEQVKEFEENFYASLSDDFNTP--------EALSHVYKLVGEL TM0719 KSGDIGIPKR-------NAVYEEYVNRFVEALDDDFNTP--------VAVSLIFELARNL AF0411 YLKTFGDRKEG-----NQVDVEDYIRRFEEAMNRDLHTP--------DAIAVLHEFAGLI APE1592 PKGRLGEGELE-----TVERLKGVVRRWHEAMSDDFNMG--------KAMSSLWEFTTIY Ta1147 --NASGNSDL-------SADPSAVIKRMVDEATNDFDFR--------SVFRDLIDFAGDL TVN1244 --YVNGSGNF-------KIDVNSVISEMRSLAENDFDFH--------SVIVKLLAITGEI DR1670 -DAPAGSDTAL------DSKIAARVTEFEDAMRDDFNTP--------KAVASLFGLTGEL Rv3580c -AVCPGDPTP----------------RFAEALDDDLSVP--------IALAEIHHVRAEG ML0323 -AVGTGELTP----------------RFAAALDDDLAVP--------IALAEVHHARVEG Rv2130c -AGPAAVDVVA---------------RVRRYLADDLDTP--------KAIAALDGWVTD- ML1302 -AGPDVADVIA---------------RVRGYLADDLDTP--------KAIAALDGWVTD- BS_cysS TEDDDQW--LE--------KVEEHRKAFEEEMDDDFNTA--------NAISVLFDLAKHA BH0111 G-GTEPW--LE--------RIDEFRGRFIEEMDDDFNSA--------NGIAVLFDLAKEA L0348 N--------LS--------ALTTFRNDFVAAMDEDFNIA--------NGMTVFYDFVSWV SPy1941 ----------Q--------ELKQFVIAFQDAMDDDFNTA--------NGITVVFDMAKWI slr0958 GWELAFTPLGP--------DANQWTVAFQEAVDDDFNFA--------GGLAVMFELAKHL cysS ---------------------EAFEARFIEAMDDDFNTP--------EAYSVLFDMAREV ZcysS ---------------------EAFEARFIEAMDDDFNTP--------EAYSVLFDMAREV VC1848 ---------------------EEYVTRFTAAMNDDFNTP--------EAYSVLFDMAREI HI0078 ---------------------ENFVATFREAMDDDFNTP--------NALSVLFEMAREI PM0945 ---------------------QNYLAAFREAMDDDFNTP--------KAISVLFEIAREI BU487 ---------------------LNFELEFYNAMNDDFNTP--------AVFSIFFKIARKI NMB2083 G--------------------DDYTRRFYVAMNDDFDTV--------KAVAVLFELAGEV NMA0347 V--------------------NDYTRRFYAAMNDDFGTV--------EAVAVLFELAGEV PA1795 ----------------------EYVERFAAAMDDDFNTA--------GACSVLFELAREV CC0460 ----------------------EAPAEVMSALMDDLNTP--LATSAFFEVSSAIEKAVT- XF0995 ----------------------FIPGNIEAALDDDLNTPQALAELATLANEARIQLADTT mlr7799 -----------------------LPVEVIDALSDDLATY--------AAFQVLTQLAGEA RP085 -----------------------LPSNFMRSLFDDMNTP--------LAIKIINDYAKCV MG253 ----SELIS------------PKQYDPVFSALLDNLNFA--------NAVAAIWKLIKKI MPN356 ----SAIPA------------PKQFEPVFKALLNNLNFA--------NAITHIWKLVKQI VNG1097G AKPADDALRT---------AVADARGEFAAAMRADFNTR--------AAVSALLELASAV UU123 KS------LT----------QIDHFELFDERINDDLDFV--------GIVDLIHISVKKI TP0091 VRGTSAECAAERVCESRASESELLLTDFRAALEDDFSTP--------RALSALQKLVRDT BB0599 TLNKDLKNFG-------FSVEKEYYDSFVEKISFDLNVA--------QGLALLWEIIKSD YNL247w GHISKKFSPLEK---ELLADFVESESKVHSAFCDNLSTP--------VALKTLSELVTKS :: jhp0818 NEKLDQNPK--------------------------------------NKALKGEILANLK HP0886 NEKLDQNPK--------------------------------------NKALKGEILANLK Cj0802 NLELDKESK--------------------------------------NKILKQNIKEALS CT782 NSSIDQHTGIQTET----------------------------DSSVFSKQDAQHILALLR CPn0932 NTLIDQG-H-------------------------------------FSKADSLYILDTLK PH0636 NKYITEA----------------------------------------EKPKESVLR--KA PAB0931 NKYILEV----------------------------------------DKPKESILR--KA aq_1068 NKVKNKA----------------------------------------YSEGKITDRELSA TM0719 SKAMDDN----------------------------------------DREDALLYYHLIR AF0411 NKSLYEL----------------------------------------SLNQAEELY---- APE1592 FREVEQT----------------------------------------ESYTLLWLSWRIL Ta1147 NKNIESI----------------------------------------SRPAAQKAI---- TVN1244 NRNFEGI----------------------------------------NKEVAEELK---- DR1670 NTALNAGPV--------------------------------------GRDTLERARDAYR Rv3580c NRALDAG----------------------------------------DHDGALRSASAIR ML0323 NRALDIG----------------------------------------DHEGALTNAGAIR Rv2130c --AVEYG----------------------------------------GHDAGAPKLVATA ML1302 --ALEYG----------------------------------------GHDAAAPKLLATA BS_cysS NYYLQKD-----------------------------------------HTADHVITAFIE BH0111 NRYLREE-----------------------------------------QTSKAVLQSFID L0348 N-------------------------------------------------KGNGGPEVKE SPy1941 N-------------------------------------------------SGSYTEPVKS slr0958 RSEGNKL-----------------------------------------KFEGSTPADLDL cysS NRLKAED-----------------------------------------MAAANAMASHLR ZcysS NRLKVED-----------------------------------------MAAANAMASHLR VC1848 NRLKSED-----------------------------------------MTNASALGSLMR HI0078 NKLKTED-----------------------------------------VEKANGLAARLR PM0945 NKLKNED-----------------------------------------ILKANALAARLR BU487 NFLKNKD-----------------------------------------ILKTNKFAFRLK NMB2083 NKTN-----------------------------------------------DAQLAGRLK NMA0347 NKTN-----------------------------------------------DAQLAGCLK PA1795 NRLRESD-----------------------------------------LSAAAALAARLK CC0460 ----AGD-----------------------------------------TVAIAANKARLL XF0995 HHAAAEV-----------------------------------------TAALTRLKAELL mlr7799 ----ADG-----------------------------------------NEAAAALKASLL RP085 F---ISK-----------------------------------------TEAERKFNASAI MG253 NTSIKTK----------------------------------------DFSVLREQLSFLE MPN356 NHDVSKQ----------------------------------------NLSGLKEHLSHLE VNG1097G NRHVDGTDT-------------------------------------YDYQGLHDAVDAFE UU123 NILIKEN---------------------------------------KDMNELKLNLTQLL TP0091 S-VP--------------------------------------------PSLCVSALQVAD BB0599 NLS---------------------------------------------FVSKLRLAFIFD YNL247w NTYITTAGAALKIEPLIAICSYITKILRIIGFPSRPDNLGWAAQAGSNDGSLGSLEDTVM jhp0818 FIEE----------LLGIGFKDPS----------------------------------AY HP0886 FIEE----------LLGIGFKDPS----------------------------------AY Cj0802 ELAK----------IFGFGFMDAT----------------------------------LY CT782 KIDQ----------VLGVLPFS-------------------------------------- CPn0932 KVDT----------VLGVLPLTT------------------------------------- PH0636 WEFFR--TVG---EIFGIFEEYFK------------------------------------ PAB0931 LEFFK--VVS---EVFGIFEDYFK------------------------------------ aq_1068 YEFASKSLLNTMKKIFGLLEDLYPECKVE----------------------------RVV TM0719 REFG--PVLG----LFDLNE---------------------------------------- AF0411 EAFKR--LCG----VLGLFE---------------------------------------- APE1592 TGFNS--VYA---FAPDIVEAR-------------------------------------- Ta1147 DVFRW--VDS----FAGILL---------------------------------------- TVN1244 KVYLW--VDT----FLGILE---------------------------------------- DR1670 SLGGD---------VLGLFAETGS---------------------------------AAS Rv3580c AMMG----------ILGCDPLDQR---------------------------------WES ML0323 AMMG----------ILGCDPLDER---------------------------------WES Rv2130c IDAL-----------LGVDL---------------------------------------- ML1302 IDAL-----------LGVDL---------------------------------------- BS_cysS MFDR----------IVSVLGFSLG----------------------------------EQ BH0111 LFNE----------LGGVLGVTLN----------------------------------RQ L0348 FFDQ----------VLEILGIKFK----------------------------------F- SPy1941 AFEK----------MLAVFGIIFE------------------------------------ slr0958 LQTQWITLVS----LAEILGLSIN----------------------------------PE cysS KLSA----------VLGLLEQEPE----------------------------------AF ZcysS KLSA----------VLGLLEQEPE----------------------------------AF VC1848 ELAD----------VIGILYQEPE----------------------------------AF HI0078 ELGA----------ILGLLQQEPE----------------------------------KF PM0945 ELAG----------ILGLLYQDPE----------------------------------QF BU487 YLAN----------NLGFLFQDPK----------------------------------EF NMB2083 ALGG----------IIGLLQRDPT----------------------------------EF NMA0347 ALGG----------IIGLLQRDPT----------------------------------EF PA1795 QLAG----------LLGVLQLEPE----------------------------------AF CC0460 EAGA----------LLGFLQADPD----------------------------------AW XF0995 GAGL----------ALGLLQQTPE----------------------------------AW mlr7799 F--------------LG------------------------------------------- RP085 ITCAN---------FIGLMR---K----------------------------------TQ MG253 WSID----------LLGISFKS-------------------------------------- MPN356 WALN----------ILGIGFKS-------------------------------------- VNG1097G TLGG---------DVLGLQFDDG------------------------------------- UU123 YMLD----------ILGINFVD-------------------------------------- TP0091 TVLG-----------LGIIQEATASLSAQ----------------------------VPA BB0599 EIMS-----------LNLREEILK------------------------------------ YNL247w PYVKCLSTFRDDVRSLAIKKAEPKEFLQLTDKIRNEDLLNLNVALDDRNGQSALIKFLTN jhp0818 FQLGVSE--SEKQEIENKIEERKRAKEQKDFLKADSIREELLQQ-------KIALMDT-- HP0886 FQLGVSE--SEKQEIENKIEERKRAKERKDFLKADSIREELLKQ-------KIALMDT-- Cj0802 FQWGVSK--EEREEIEKLILERTEAKKNKDFNTADAIREQLNSK-------KITLLDT-- CT782 -------QPDIPEEVLLLVEQREAARKVKNWQEADRLRDEILSR-------SFAIEDG-- CPn0932 -------SVCIPETVMQLVAEREEARKTKNWAMADTLRDEILAA-------GFLVEDS-- PH0636 --EEKAK--EEEKLIELLIQVRAELRKERKFELADKIREELRKL-------GIQLEDK-- PAB0931 --EEKKG--EEEKLIELLVEVRKQLRKEKRFDLADKIREELRKL-------GIQLEDK-- aq_1068 ERELEAGQVFDEKLIQILIEARNIARKEKVFKVADYIRDKLKEL-------GIVLEDT-- TM0719 --EKKE--VSSEELLKLLIEVRDVLRKEKRYDLSDRIRDRLREI-------GIILKDT-- AF0411 --KMERVPALSREDAEKVVE-RERARKERNFELADAIRDEFAKR-------GIRLIDT-- APE1592 --RPERS--LEDSLVQALVDVRSELRRRKMYDLADEIRSRLAQL-------GFVLHDK-- Ta1147 ---PETA--RLSGIIDDLLDLRKNLRTERKFQEADRIRDLLLKN-------GIHVEDR-- TVN1244 ---QKKE--VSKGIVDDLVELRTRMRKEKNFLISDAIRDVLKKN-------GIHIEDR-- DR1670 VAQDDAS--VIDALMDLVLKARQNYRLQKQYAEADELRETLGKA-------GITVEDT-- Rv3580c RDETSAALAAVDVLVQAELQNREKAREQRNWALADEIRGRLKRA-------GIEVTDT-- ML0323 RDETSAALAAVDVLVAAELESRQMAREQRNWVLADQIRDRLKDA-------GIEVTDT-- Rv2130c ------------------------------------------------------------ ML1302 ------------------------------------------------------------ BS_cysS E--------LLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSM-------NIILEDT-- BH0111 EE-------LLDEEIERLIEERNEARKAKNFQRADDIRDQLKAE-------GIILEDT-- L0348 EQ-------SLDSEIEAMIEARQLAREVRDFAKSDEIRDALKAQ-------GIVLEDT-- SPy1941 EE-------VLEVDIEALIAKRQEARANRDFATADAIRDQLAVQ-------GIKLLDT-- slr0958 SQSSNDNG-LTDGDIEQLVAQRTQARKDKNWAEGDRLRDVLQEA-------GITLVDK-- cysS LQSGAQADDSEVAEIEALIQQRLDARKAKDWAAADAARDRLNEM-------GIVLEDG-- ZcysS LQSGAQADDSEVAEIEALIQQRLDARKAKDWAAADAARDRLNEM-------GIVLEDG-- VC1848 FQG--SAEDEDAAQIEALIKLRNDSRATKDWANADLARDKLNEM-------GIVLEDG-- HI0078 LQAG--SNDDEVAKIEALIKQRNEARTAKDWSAADSARNELTAM-------GIVLEDG-- PM0945 LQSG--SDNDEVALIEALIKQRNDARAAKDWASADAARNKLAEM-------GVVLEDN-- BU487 LQKKTTLNLLTLKEIQLLIEKRNIARQSKLWQEADNIRKKLMSL-------DIILEDL-- NMB2083 LQGGAASDGLSNEEIEDLIARRKQARADKNWAESDRIRDLLNEH-------KIILEDN-- NMA0347 LQGGAASDGLSNEEIEDLIARRKQARADKNWAESDRIRDLLNEH-------KIILEDN-- PA1795 LQAGAEGK-VDAAEVEALIQARLEARAAKNWAESDRIRDQLTAM-------GVVLEDG-- CC0460 FEGDASDE--LKAQVEDLLAKRVAARAAKDWSAADAIRGELDAL-------GVVVMDG-- XF0995 FSQGTNES--DETHIQALIDARGAAKQARDFVRADAIRAQLAAE-------GIVLEDT-- mlr7799 FDVASADI--DEDGVAKAIANRLALIAAKNWTEADRIRDELLAQ-------GVQLKDGKD RP085 YEWFNRDV--DEFYINELINKRLKAKKQKNWLLADKIRNQLLEK-------KIILEDK-- MG253 ---------IHTKLNVRLIKEWSILHKQKAMDKADQIRKKLIKK-------MLL------ MPN356 ---------IHTKLNVQLIKKWASLRKNGQLDKADEVRQKLIKK-------GLL------ VNG1097G --AGEDAVSLADDVIDLVLDVREQERTAGNYERADDLRDRLEAL-------GVSVEDT-- UU123 ---------LHNDENLALLNTWKNYVDKKDYVKADELRKQLINI-------GIL------ TP0091 GDTLPQRPLPSEEWIGQLVRARAHARQTRDFPRADEIRRQLKAE-------GIELEDT-- BB0599 -N-LQNHDVVIDENMKALIEERRIAKCEKNFKRADEIRDFFAKK-------GFVLVDT-- YNL247w DEKLEIVKLNEEKHANELAKKQKKLEQQKLREQKENERKQKAQIKPQDMFKDVTLYSAWD jhp0818 PQG--------------------TIWEKLF----------- HP0886 PQG--------------------TIWEKFF----------- Cj0802 PNG--------------------TIWEKINA---------- CT782 KTG--------------------MKVKKL------------ CPn0932 KSG--------------------PKVKPL------------ PH0636 GKE--------------------TIWKRIKV---------- PAB0931 GQE--------------------TVWKRVKVS--------- aq_1068 PAG--------------------TKWKKREGA--------- TM0719 PSG--------------------TEYTVE------------ AF0411 PKG--------------------TRWRVE------------ APE1592 GEK--------------------TEWRRR------------ Ta1147 GDE--------------------TIWW-------------- TVN1244 GDV--------------------TVWWQE------------ DR1670 KDG--------------------ARWKR------------- Rv3580c ADG--------------------PQWSLLGGDTK------- ML0323 VNG--------------------PQWELLAGDKQVDAR--- Rv2130c ----------------------------------------- ML1302 ----------------------------------------- BS_cysS AQG--------------------TRWKRGE----------- BH0111 PQG--------------------VRWKRGS----------- L0348 KDG--------------------VRWHRE------------ SPy1941 KDG--------------------VRWLRD------------ slr0958 PGGL-------------------TEWFR------------- cysS PQG--------------------TTWRRK------------ ZcysS PQG--------------------TTWRRK------------ VC1848 PNG--------------------TTWRRK------------ HI0078 PNG--------------------TTWRKQ------------ PM0945 VNG--------------------TTWRKQ------------ BU487 PDK--------------------TIWRKNKKS--------- NMB2083 AGG--------------------TTWRRG------------ NMA0347 AGG--------------------TTWRRG------------ PA1795 KGG--------------------TTWRLAD----------- CC0460 PAG--------------------ATWRMKD----------- XF0995 PHG--------------------VRWMKQHT---------- mlr7799 PVTGER----------------ITTWEVKR----------- RP085 SNY-------------------ITIWRKE------------ MG253 ----------------------------------------- MPN356 ----------------------------------------- VNG1097G DDG--------------------ATVRR------------- UU123 ----------------------------------------- TP0091 HLG--------------------TIWKRV------------ BB0599 KEG--------------------TKVKRG------------ YNL247w EQGLPTKDKDGNDITKSMTKKLKKQWEQQKKLHEEYFGEDK