CLUSTAL W (1.74) multiple sequence alignment MJ1000 --------------------------------------------------MIVMFQKPRG MTH244 ---------------------------------MNDEPLIIPFIIFTGGIAVMDISRPRG AF1642 ----------------------------------------------------MKIERPRG PH0290 -----------------------------------------------------MIERVKG PAB1100 -----------------------------------------------------MIERVKG Ta0099 -------------------------------------------------MYRLQIEKIRG TVN0154 ----------------------------------------------------MQIERIKG mlr6928 ---------------------------------MADKSE------------KTKARLPRG CC3513 ---------------------------------MTTDSEQP------NTDFRPEARAPRG jhp1115 ---------------------------------------------------MITPKVLSG HP1190 ---------------------------------------------------MITPKVLSG hisS --------------------------------------------------MAKNIQAIRG ZhisS --------------------------------------------------MAKNIQAIRG VC0760 --------------------------------------------------MAKTIQAIRG HI0369 --------------------------------------------------MAKTIQAIRG PM2011 --------------------------------------------------MAKTIQAIRG PA3802 --------------------------------------------------MSKSLQAIRG NMB0854 --------------------------------------------------MAQKIQSVKG NMA1065 --------------------------------------------------MAQKIQSVKG BU288 --------------------------------------------------MNKEIKSIRG BS_hisS ----------------------------------------------------MGYNIPRG BH1251 ----------------------------------------------------MAIQIPRG L0342 ----------------------------------------------------MKLQKPKG SPy2157 ----------------------------------------------------MKLQKPKG slr0357 ---------------------------------------------------MGAIQAIRG aq_122 ----------------------------------------------------MNIQSVRG TM1090 ----------------------------------------------------MKYRRIKG Rv2580c ---------------------------------------------MTEFS---SFSAPKG ML0494 ---------------------------------------------MTESCTVFSFSGPKG CT543 ----------------------------------------------------MSNALPKG CPn0663 ----------------------------------------------------MTVTLPKG MG035 ---------------------------------------------------MNFLQKPRG MPN045 ---------------------------------------------------MSVLQKPRG Cj0765c -----------------------------------------------------MINALKG RP308 -----------------------------------------------MNYMIENLQPLRG DR1349 ----------------------------------------------------MAIQRPKG UU285 ---------------------------------------------------MINYSKPRG VNG2005G -----------------------------------------------------MYDRLKG BB0135 ---------------------------------------------------MMDIKTLKG TP0641 ----------------------------------------------MRVGSAVSPKVLKG XF2222 ---------------------------------------------------MIKPRTPPG APE0662 ----------------------------------------------MPQVAGGRPRPPRG YPR033c MLSRSLNKVVTSIKSSSIIRMSSATAAATSAPTANAANALKASKAPKKGKLQVSLKTPKG aq_1155 ----------------------------------------------------MKTSLISG L0341 ------------------------------------------------------------ mlr6929 ------------------------------------------------------------ CC3512 ----------------------------------------------------MRCARSSG TM1043 ------------------------------------------------------------ YDR283c_2 -----------------------------------------SSPWQQQVRESLFNQSYSL MJ1000 TRDFLPEEM---------KKRRFVENKLREVFERYGYKEILTPTFESFELIA--KKTG-E MTH244 TRDFLFAEM---------RNRKEVEGVLRRTFETYGYHEIKTPIFEELKLFT--VKSG-E AF1642 TRDFLPDEM---------ERRREIEKRMRKIAESFGYREVATPTFEYLELFT--RKSG-E PH0290 TRDFLPEDM---------AKRRWVFEKIREVFEAYGFKEILTPVMEYTKLFQ--LRSG-E PAB1100 TRDFLPEEM---------VKRRWVFEKIREVFETYGFKEVLTPVMEYTKLFQ--LRSG-E Ta0099 FRDFYPEDM---------DVEKFIFKTAEEAAEAFGFRRIDFPSLEYLDLYR--IKSG-E TVN0154 FRDFYPEDM---------EIEKFIFETASSVAESYGFKRIDFPSLEYIDLYR--IKSG-E mlr6928 FADRSAEDI---------RAVEKMMATIRSVYELYGFEPADQPLIEYTDALGKFLPD--Q CC3513 FADKRARDL---------RAERAILEAVSAVYERYGFEALDTGAFEYADALGKFLPD--S jhp1115 FKDRLPKDA---------IQKAQLLAKVSVVFQSFGFVPIETPHLEYAQTL---LPDASS HP1190 FKDRLPKDA---------IQKAQLLAKVSVVFQSFGFVPIETPHLEYAQTL---LPDASS hisS MNDYLPGET---------AIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEV-T ZhisS MNDYLPGET---------AIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEV-T VC0760 MNDCLPTQS---------PLWQKVEGVVKNVISAYGYSEVRMPIVEMTHLFSRAIGEV-T HI0369 MNDCAPTES---------PLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEV-T PM2011 MNDCSPTES---------PLWQWVEGKVRSVLQNYGYSEVRMPIVESTPLFARAIGEV-T PA3802 MNDILPEQT---------PAWRYLERTFAGLLDGYGYSEIRLPILEFTELFARGIGEG-T NMB0854 MNDLLPVKQKDFKLT--AAFWQAFEDTVGRWTRAYGYQQIRTPIVEQTGLFVRSIGEE-T NMA1065 MNDLLPVEQKDFKLT--AAFWQAFEDTVGRWTRTYGYQQIRTPIVEQTGLFVRSIGEE-T BU288 MYDYFPKDL---------KIWNYIEIIFKEVLNSYCYLEIRLPILEKTEIFKRAIGNV-T BS_hisS TQDILPGES---------DRWQFVEQIMRDTCRTYQYKEIRTPIFEHTELFARGVGES-T BH1251 TQDILPGDV---------ETWQWIEQKAYDLCRRYNYQEIRVPMFEHTELFLRGVGDT-T L0342 TADLLPAET---------AKWQYIEEIARGVFNDYNFKEIRTPMFESYELFSRATGET-S SPy2157 TQDILPGDA---------AKWQYVESVARDTFSQYNYGEIRTPMFEHYEVISRSVGDT-T slr0357 TRDILPPET---------NYWQWVEAIAKSILDRALYQEIRTPIFEQTSLFERGIGEA-T aq_122 FHDILGKDA---------KKFRKISDTARKILKLYNFEEIILPVVEYAELFQRSVGET-T TM1090 TNDIFGEEI---------WYWRYVEETFRNVCESAGIEEIRTPIFEQTELFVRSVGEE-S Rv2580c VPDYVPPDS---------AQFVAVRDGLLAAARQAGYSHIELPIFEDTALFARGVGES-T ML0494 IPDYFPPDS---------AQFVAVRDGLLTAARRAGYGDIELPVFEDTALFARGVGES-T CT543 VFDIFPYVTSPKNLWRNSSLWKRVEHAAHRICNLYGFDEIRTPVFEKTETFLR-VGEY-S CPn0663 VFDIFPYLADAKQLWRHTSLWHSVEKAIHTVCMLYGFCEIRTPIFEKSEVFLH-VGEE-S MG035 VKDWFGDEL---------VYFNWIVKKIRSLAFNWGFSEVKTPLFENAQLFQR-SNAN-A MPN045 VKDWYGEEL---------IYFNWTVHQITNLAWKWGFSEVKTPLLEYAEAFKR-TNAN-A Cj0765c MKDLLDKDA---------YYYEKVIKICEEVAKNYGFTFINTPHLELCTLFKRSVGES-S RP308 MKDLLPNDY---------QIHNYIINKARDVGALYGYKQMSTPILEYTKVFNRSMGES-S DR1349 TNDLLPSGSPKTEAFQRAAAHEWLIAQAREVLERAGAQRIDTPMFEEAELVKRGVGGS-T UU285 TIDLYNKEM---------NDFKLLENFLLSTTKRYGFQQIKTPVFEFAELFMKSAGES-S VNG2005G FRDFYPAEM---------GPRRAAIDAIEDAAASYGFREVGTPAMERTEMY---VDKSGA BB0135 FKDYLPKDS---------LIRIHIVRQIFSVLNSYNFDLIDTPVLEYSDLL---LKKS-G TP0641 FRDLLPDEE---------IERALLVEKLTVALRQMGFVPIDTPALEYTEVL---LRKS-E XF2222 VLELLPREQ---------IAFQRMLDVIRRNYERFGFLPVETPVFELSDVL---LTKS-G APE0662 FRDFPPEVM---------ILRKRLLSRLERVFESYGFDPLDTPAVEYWETLS---GKYGE YPR033c TKDWADSDM---------VIREAIFSTLSGLFKKHGGVTIDTPVFELREILAGKYGED-- aq_1155 ERFYSLEES---------NLVKEIFKKAVKIFEAFGYDYINLSHFEPYEFQELTFGEG-- L0341 ----------------------------------------MPPSFEYTQLYTALESNG-K mlr6929 ----------------MTSRFPAIAANITKLFAARNTHAVEVAILQPADPFLDMAGED-- CC3512 VEVRLERSI-----------PAPALDAIRAPLLDAGAVLTDAPVLQPLGLLLDLAGEA-- TM1043 -MDFLDFEK------------VFSFYSK---ATKKGFSPFFVPALEKAEEP---AGN--- YDR283c_2 TNDILFDNS--------VPTSTPFANILRSQMTEEVVKIFRKHGGIENNAPPRIFPKA-P MJ1000 EIRKQ-LYVFKDH------------GGREMALRPEMTSPVVRFYLNELKNLQ----KPLR MTH244 EVVNQ-IYHFTDK------------GGRELALRPELTAPVARLYMNEMQKKP----KPIK AF1642 GIIEE-MYVFKDK------------SGRDLALRPELTAPVMRMFVNECSVMP----KPLR PH0290 EVVKQ-LYAFKDK------------GGRDVSLRPDMTSSVARLYVNSFQMAP----KPIK PAB1100 EVVKQ-LYAFKDK------------GGRDVALRPDMTSSVARLYVNSFQTAP----KPIK Ta0099 ELLQQ-TYSFVDK------------GGREVTLIPEATPSTVRMVT-SRKDLQ----RPLR TVN0154 ELLNQ-TYSFTDR------------GGREVTLIPEATPSTVRMLT-SRKDIA----KPVR mlr6928 DRPNEGVFSFQDD------------DEQWLSLRYDLTAPTARFVAENYERLP----KPYR CC3513 DRPNEGVFALQDD------------DDQWMALRYDLTAPLARFAAQNWETLP----KPFR jhp1115 DIQKE-IYRFKDH------------GDRDVALRFDLTVPLARFVSLHHQILG----MPFK HP1190 DIQKE-IYRFKDH------------GDRDVALRFDLTVPLARFVSLHHQTLG----MPFK hisS DVVEKEMYTFEDR------------NGDSLTLRPEGTAGCVRAGIEHGLLYN----QEQR ZhisS DVVEKEMYTFEDR------------NGDSLTLRPEGTAGCVRAGIEHGLLYN----QEQR VC0760 DVVEKEMYTFEDR------------NGDSLTLRPEGTAGCVRSGIENGLLYN----QEQR HI0369 DVVSKEMYTFWD-------------NDEQLTLRPEGTAGCVRAAIEHGWIYN----NEQR PM2011 DVVSKEMYTFWD-------------NDEQLTLRPEGTAGCVRAAIEHGWIYN----QEQR PA3802 DVVDKEMYTFLDR------------NGESLTMRPEGTAGCVRAVLEHGLSGG---GQVQK NMB0854 DVVGKEMYTFSDS-----------NDSLSLSLRPEGTASCLRAVVEHNLLYN----SPQK NMA1065 DVVGKEMYTFSDS-----------NDSLSLSLRPEGTASCLRAVVEHNFLYN----SPQK BU288 DVVEKEMYSFNDR------------KGNNLTLRPEGTVGCVRAIIQNNLLQK-----SNK BS_hisS DIVQKEMYTFEDR------------KGRSLTLRPEGTAAAVRAFNENKLFA-NPV-QPTK BH1251 DIVQKEMYTFEDR------------GGRSLTLRPEGTASVTRAYVSNKLYG-QAN-QPTK L0342 DIVTKEMYDFEDK------------GGRHIALRPEGTASAVRAYIENKLYAPEVV-KPVK SPy2157 DIVTKEMYDFYDK------------GDRHITLRPEGTAPVVRSYVENKLFAPEVQ-KPVK slr0357 DVVGKEMYSFTDR------------GDRPITLRPEGTAGVVRAYIEQNLQA--AG-GVQR aq_122 DIVQKEMFVFEDR------------KGRKLALRPEGTAGTVRAFIQHKLYA--LR-PYVK TM1090 DIVQKEMYTFQDK------------AGRSITLRPEGTAPVVRAFLENSLID--RG-FQQR Rv2580c DVVSKEMYTFADR------------GDRSVTLRPEGTAGVVRAVIEHGLDR--GA-LPVK ML0494 DVVAKEMYTFADR------------GDRSVTLRPEGTAGVVRAVIEHGLDR--GA-LPVK CT543 DIVKKEVYTFLDK------------KRRSLTLRPEGTAAVVRALLDHSADMR----KDNK CPn0663 DVVKKEVYSFLDR------------KGRSMTLRPEGTAAVVRSFLEHGASHR----SDNK MG035 DIVQKELYQFFDK------------SQRELALRPEATTPIVRLACENKLMQE--ANFPLK MPN045 DIVKKELYEFHDK------------SNRLLALRPEATAGIVRLVCENKLLQP--QNYPLR Cj0765c DIVGKEMYEFIDK------------GENHVCMRPEGTAGVVRAYIEKKLDKN---TSVKR RP308 DVMSKEIYSFVDK------------SNNAVALRPEFTSGIIRSFISNGLQHK----LPLK DR1349 DIVRKEMFTVYYF-----------GDHGGYVLRPEGTASIVRAYLENGLKQLP---APLK UU285 DLVSKEMYLFKDK------------SDRWLALRPEGTAGVIRAVVENKLLLN--HPLPLK VNG2005G EIVDE-LYSFTDQ------------GGRDVALTPELTPTVARMVVAKQQALS----KPIK BB0135 DETEKQIYRFKDN------------GGRDVSMRFDLTVPFARFVATNISALK----LPFR TP0641 GDTEKQMFRFVDK------------GGRDVALRFDLTVPLARFVATHYARLY----FPFK XF2222 GETERQVYFVQSTGTLANAAESGATRLPELALRFDLTVPLARYVAEYEHVLA----FPFR APE0662 EAESRLIWRFQDP-----------WSGRWYALRYDLTVPLARFVASNPGLP-----MPFK YPR033c ---SKLIYNLEDQ------------GGELCSLRYDLTVPFARYVAMNNIQS-------IK aq_1155 ---SKEAITFKDS-----------YTKESFGLRLDFTTQVVRTISHLRNVK-----LPER L0341 TFNQEKMFQFIKH------------EGQSITLRYDFTLPLVRLYSQIKDSTS------AR mlr6929 -LRRR-IFLTESE------------TGQTLCLRPEFTIPVCLDHISSQAGT------PRR CC3512 -MRSR-LFVVSGE------------AGEEACLRPDFTVAVARQHFEGGGGAG-------R TM1043 -------F-FLDR------------KGNLFSIREDFTKTVLNHRKRYSPDSQ------IK YDR283c_2 IYGTQNVYEVLDK------------GGTVLQLQYDLTYPMARYLSKNPSLIS-------K : : * : MJ1000 LYYFANCFRYERPQA--GRFREFWQMGCELIGCK---EPLADAEVLNLAMDGLINIGLD- MTH244 MYYFGSCFRYERPQA--GRFRQFWQFGCELIGGR---SPLAEAEVISLASESLHELGLDG AF1642 FYYFANCFRYERPQK--GRYREFWQFGVELIGSE---SYLADAEVIILADKILKDVGVN- PH0290 WYYIANMFRYEEPQS--GRYREFWQAGVELIGSD---KVEADAEVIALFVESYLSTGLRD PAB1100 WYYIANMFRYEEPQS--GRYREFWQAGVELIGSD---KIEADAEVIALFVDSYLSTGLKD Ta0099 WYSFPKVWRYEEPQA--GRYREHYQFNADIFGSD---SPEADAEVIALASSILDRLGLQD TVN0154 WYSFPKVWRYEEPQA--GRFREHYQFNADIFGPS---NEEADAEIISLASGILDGLGLSG mlr6928 SYRSGWVFRNEKPGP--GRFRQFMQFDADTIGTP---GVAADAEMAMMMADVMEALGIKR CC3513 RYAFGPVWRNEKPGP--GRFRQFIQCDADTVGSA---RPEADAEIIAMAVEGLEAAGLPR jhp1115 RYAIGNVFRGERAQK--GRYREFTQCDFDFIGSE---SLVCDAEIIQVIIASLKALDLE- HP1190 RYAIGNVFRGERAQK--GRYREFTQCDFDFIGSE---SLVCDAEIIQVIVASLKALDLE- hisS LWYIGPMFRHERPQK--GRYRQFHQLGCEVFGLQ---GPDIDAELIMLTARWWRALGISE ZhisS LWYIGPMFRHERPQK--GRYRQFHQLGCEVFGLQ---GPDIDAELIMLTARWWRALGISE VC0760 LWYMGPMFRHERPQK--GRYRQFHQCGVEVFGLD---GPDVDAELIMMTARLWRELGIAQ HI0369 LWYIGPMFRHERPQK--GRYRQFHQVGVEVFGIA---NPEIDAELIMLTYRLWKALGIDQ PM2011 LWYMGPMFRHERPQK--GRYRQFHQAGVEVFGIP---NPEIDAELIMLTARLWKELGIAE PA3802 LWYTGPMFRYEKPQK--GRYRQFHQIGVEVFNLP---GPDIDAELIILTWRLWQKLGMAD NMB0854 LWYMGPMFRRERPQK--GRYRQFHQVGIEALGFE---GPDIDAEIIAMSADLWEKLGIRE NMA1065 LWYMGPMFRRERPQK--GRYRQFHQVGIEALGFE---GPDIDAEIIAMSADLWEKLGIRE BU288 FWYLGPMFRYERPQK--GRYRQFYQLGAEVFGLD---TEDIDLEIIILTNRLWKRIGIDS BS_hisS LYYVGPMFRYERPQT--GRYRQFYQFGIEAIGSK---DPAIDAEVMALAMSIYEKAGLEN BH1251 LFYIGPMFRYERPQS--GRMRQFVQFGVEALGSA---DPAIDAEVLALVMRFYEELGLKN L0342 LWYDAPMFRYERPQS--GRLRQFHQFGVECLGVK---NPAVDVEIIAMADTLFRQLGITG SPy2157 LYYIGSMFRYERPQA--GRLREFHQIGVECFGAA---NPATDVETIAMAYHLFEKLGIKD slr0357 LWYTGPMFRYERPQA--GRQRQFHQLGVEVLGSA---DPRADVEVIALGTDILKALGLSN aq_122 LFYEGPMFRYERPQA--GRYRQFHQIGAEVFGVA---EPHADAEIIKIVYDILQALGIKG TM1090 YYYIGPMFRYEKPQS--GRLRQFHQVGFEIIGPE---SPKADFEVIMLVDTFLRRLGLTK Rv2580c LCYAGPFFRYERPQA--GRYRQLQQVGVEAIGVD---DPALDAEVIAIADAGFRSLGLDG ML0494 LCYAGPFFRYERPQA--GRCRQLQQVGVEAIGVD---DPALDAEVITIADAGFRSLGLDG CT543 FYYILPMFRYERQQS--GRYRQHHQFGLEAIGVR---HPLRDAEVLSLLWDFYAAVGLQH CPn0663 FYYILPMFRYERQQA--GRYRQHHQFGVEAIGVR---HPLRDAEVLALLWDFYSRVGLQH MG035 LFCIGSMYRYERPQN--NRFREHWQFSCEVFGFS---NLFIFLDTLLFANSLLEALGITG MPN045 LFTIGTMYRYERPQS--NRYREHYQFSCEVIGDT---NPTVLLDTLLLGHAIIQQLGIEG Cj0765c WFYYGSMFRYERPQK--GRLREFHQFGVESLGIP---NVYEDASIILMLVEIFSRLGID- RP308 FFSTGPVFRYDRPQA--GRQRQFHQLNYEYLGAK---GAITDAETVKLAVDILKALEIEE DR1349 LWTSGPMFRAERHQK--GRYRQFTQVDYEVLGSA---DALVDAEAIALMVAVVQKLGLRG UU285 LMYFEPCFRYERPQA--GRQRQFHQFGVEVLGTK---NIYYDFELIALADTILKKLMISN VNG2005G WYSSRPFWRYEEPQQ--GRFREFYQTNLDIFGTS---DPRADAEVLAVAADGLTSLGLTG BB0135 RSQFGKVFRGENSQK--GRYREFMQFDFDIVGED---TFRGDAEILSVVYYGLEEIFLNF TP0641 RYHFAKVWRGEKPQM--GRYREFTQCDFDIVGSD---SVCADFEILKSIRHMLYMAGAEH XF2222 RYQMQRVYRGERAQR--GRFREFYQCDIDVIGKQT-LSIRYDAEVLAVIHAVFSELGIGD APE0662 RYHIGKVWRHEEPQK--GRYREFVQCDADIVGSP---YPEADAEIVSLAVDSIDALGLPG YPR033c RYHIAKVYRRDQPAMTKGRMREFYQCDFDVAGTF--ESMVPDSECLSILVEGLTSLGIKD aq_1155 VYYFGKVFSLDRRGF------EKLQTGVELIGEK---SILADFEVIQVLTEFLKSLGLKD L0341 YSYFGKIFRKEKRHK--GRSTENYQIGIELFGES---ADKSELEILSLALQVIEQLGLNK mlr6929 YSYLGEVFRQRREGG-----NEFFQAGIEDLGDR--DTAQADARSVADAHALLSLVLPGR CC3512 RRYEGKAFRVAPRGS--DRAEEFLQLGVEAFETG--DRVAADAEMAALAWASAVAGGRED TM1043 VWYADFVYRYSGSDL-----VAEYQLGLEKVPRN---SLDDSLEVLEIIVESASEFFEGP YDR283c_2 QYRMQHVYRPPDHSRSSLEPRKFGEIDFDIISKSSSESGFYDAESLKIIDEILTVFPVFE : : . : MJ1000 -------FDVHIGHLGVLKGVLEKF----NVSEEEEVKIRRLIDKED----YDNLK---- MTH244 -------FEVHIGHLGILRGILGRE----EIPSELQDRIMGVIDKGD----VEELE---- AF1642 -------FSLEIGHVGIMRHLLKP------IGEDRASKVMRLIDKGD----REGLE---- PH0290 -------FTVNIGDRILLDEFAGM------LGVSDDIGLMRIIDKRDKL-SQEEFI---- PAB1100 -------FTVNIGDRVLLDEFAKM------LGVKDDIGLMRIIDKKDKL-SQEEFL---- Ta0099 -I-----YEIRINSRKIMEEIIGG------MTSSDPFSVFSIIDRYHKI-SREEFV---- TVN0154 -A-----YEIRVNSRIMMEDILNG------MGIADPYTVFSIVDRFHKV-SKETFV---- mlr6928 GD-----YVIRVNNRKVLDGVLEAIGLGGEENIGRRLTVLRAIDKLDKL-GPEGVKLLLG CC3513 GT-----AVLKINNRKLLNGLLTAA---GADSAGQKLAVLRAVDKLDRL-GVDGVRLLLG jhp1115 -D-----FCVSINHRKILNGICEYF----G--IAQVNEVLRIVDKLEKI-GLNGV----- HP1190 -D-----FCVSINHRKILNGICEYF----G--ISQVNEALRIVDKLEKI-GLNGV----- hisS H------VTLELNSIGSLEARANYR-------DALVAFLEQHKEKLDED-CKRRMYT--- ZhisS H------VTLELNSIGSLEARANYR-------DALVAFLEQHKEKLDED-CKRRMYT--- VC0760 H------VRLELNSIGSLEARANYR-------TALIDYLEQYQNVLDED-CKRRMYT--- HI0369 H------VTLQLNSIGSLEARANYR-------SALVGFLENHQDLMSDE-EKERLVR--- PM2011 H------VTLQLNSIGSLEARKNYR-------SALVAFLQQHVDLLSEE-EKERLEK--- PA3802 A------VTLQLNTLGSSEARARYR-------EALVAYLQERFEQLDED-SQRRMTT--- NMB0854 Y------LTLEINSLGNREERAAHR-------AALVEYLTRYEDKLDED-SKRRLKT--- NMA1065 Y------LTLEINSLGNREERAAHR-------AALVEYLTRYEDKLDED-SKRRLKT--- BU288 F------ITLEVNSIGSKIDRVQYK-------KELVNFLKKREYLLDED-CKRRLYT--- BS_hisS -------VKLVINSLGDQDSRKSYR-------EALVKHFEPRIEEFCSD-CQSRLHT--- BH1251 -------LKLVINSLGDTDSRLAHR-------EALVNHFKPRIHEFCND-CQDRLEK--- L0342 -------LKLALNTLGDMESRMAYR-------QALIDYLTPFENQLSED-SRRRLNE--- SPy2157 -------VTLHLNSLGSPESRAAYR-------QALIDYLTPMRDQLSKD-SQRRLDE--- slr0357 -------LSLALNSVGNGGDRQRYR-------EALIAYLTPFKAELDPD-SQDRLER--- aq_122 -------VVVEINSLGCKKDREAYR-------EALLNYLTGVKEELCSD-CISRMDR--- TM1090 -------YKIHLNSIGCPVCRKNYR-------EALKEYYGRILDNLCDD-CKRRYET--- Rv2580c -------FRLEITSLGDESCRPQYR-------ELLQEFL--FGLDLDED-TRRRAGI--- ML0494 -------FQLEITSLGDGTCRPQYR-------KLLQEFL--LQLDLDED-TRRRAEL--- CT543 -------MQIHVNFLGGQKTRARYD-------EALREFFRKDLDRLSPL-SQERYHA--- CPn0663 -------MQIQLNFLGGSETRFRYD-------KVLRAYLKESMGELSAL-SQQRFST--- MG035 -------YVLKINNLANFETLSKWN-------KALKDYLTPYKLELTEL-SQKRLEK--- MPN045 -------VILKLNNLGNSATIQQWN-------QALQAYLTQFKAQLTEL-SQSRLST--- Cj0765c -------FKLQLNSLGCSQCLPKYR-------DRLVEFLD-SKEGFCED-CLRRKNL--- RP308 D------TTLELNSLGCHESRIVYQ-------QKLVEYLNDFKDQLSGE-SRLRLNK--- DR1349 -------VRVKLGSIGDPEDRERYN-------AYLRDLFSPHLGRLSDD-SKDRLER--- UU285 -------YILEINYISSPHNRSLWV-------KSLQEYFHLHRTELTPL-SQERITT--- VNG2005G AD-----FEFRVSHRDILGGLLAAFD-----ATVDTEAAIRTVDKREK---IERAAYL-- BB0135 IEGINKKFIIHYSHIGILNSFFEKLG-----LKEKSIFILRNIDKIDKI-GIDKVK---- TP0641 -------IRIHVAHRGLFDRFLRALS-----LSDQAEHILRIIDKRAKM-APHVLTAQLE XF2222 -------FQVQLNNRKVLRGFLESQG---VRDGDLQLAVLREVDKLDKR-GVLDVRDTLI APE0662 -------FRVRVNDRRLLAGVFEEELG-----FDNPLPIYRAIDKLDKI-GVEGVR---- YPR033c -------FKIKLNHRKILDGIFQIAG----VKDEDVRKISSAVDKLDKS-PWEAVKK--- aq_1155 -------LKVILSHAGIVRKVADER----------EELLRAFSERNLEA-LKEVLG---- L0341 -------TVFEIGSAKFFQRLCQLA-------DGSTELLTELLLKKDLS-GLNAFIEK-- mlr6929 S------LAVTLGDQGIFEAVLAALG----LPRGWRMRLARAFGSAPML-QAALADLA-- CC3512 -------LSLVLGDVSLFSAFVESLD----LAPPLAARLTRSFAKPRQL-KAELDG---- TM1043 -------VIVEIGHTGVYEDLLKEIP------KDLHEKVLNLIDTKNLA-EIEFLS---- YDR283c_2 KTN----TFFILNHADILESVFNFTN----IDKAQRPLVSRMLSQVGFARSFKEVKN--- . MJ1000 ------------IYLTQILGE--EKKELIFEILKFK-GSRE-VLDELKEI----LKD--F MTH244 ------------ALLGEVEVSG-ESRELLMKLIGTQ-GGPE-VLDDVEEY----LGG--Y AF1642 ------------SYLAEIRVNE-DLRDKIFSLLELK-GDES-VIEEAKEI----ID---- PH0290 ------------NLLKEFGLGE-SEIEKVLELVEIK-GRPDNVLPLAEEL----FKSKKA PAB1100 ------------KALGEFGLDE-NGIEKVLNLIEIK-GKPDDVLPLAEEL----FTSERA Ta0099 ------------DQLRSAGIGE-DGVSMIADLCSGT-R----GIDEMARI----TGK--S TVN0154 ------------DDLMSVGLSE-ENSNTIYRMCSEA-SEPG-GISGLFG-----SGK--V mlr6928 PGRWDGGKEGEGDFAKGAGLNN-GQAEAVL---QAT-ARN-AQAAQDS----VVDSNATY CC3513 EGRLD----ESGDFTKGAGLKG-KAVDQVLDFVQAG-STG-GRAATLDNIARVVAGSAEG jhp1115 ---EE-------ELKKECDLDS-NTIKDLLEMVQIK-QNDLSHAEFFEKIAYLKDYNENL HP1190 ---EE-------ELKKECGLNS-NTIKELLELIQIK-QNDLSHAEFFEKIAYLKDYNENL hisS ------------NPLRVLDSKN-PEVQALLND-------APALGDYLDE----------- ZhisS ------------NPLRVLDSKN-PEVQALLND-------APALGDYLDE----------- VC0760 ------------NPLRVLDSKN-PDVQAILGD-------APQLSDYLDA----------- HI0369 ------------NPLRILDTKN-PELQKVLDN-------APKLLDYLDD----------- PM2011 ------------NPLRILDTKN-QALQEVLND-------APKLLAYLDD----------- PA3802 ------------NPLRILDSKV-ESTQALLVG-------APTLHDYLDE----------- NMB0854 ------------NPLRVLDTKN-PDLQEICNA-------APRLVDYLGE----------- NMA1065 ------------NPLRVLDTKN-PDLQEICNA-------APRLVDYLGE----------- BU288 ------------NPLRILDSKN-QDIQNLLKE-------APLLSEYISF----------- BS_hisS ------------NPLRILDCKK-DRDHELMKS-------APSILTYLNE----------- BH1251 ------------NPLRILDCKK-DRDHELMGT-------APSIHDYLST----------- L0342 ------------NPLRVLDSKE-AEDIAIVKN-------APAILDYLNE----------- SPy2157 ------------NPLRVLDSKE-KEDKLAVEK-------APSILDYLDE----------- slr0357 ------------NPLRILDSKA-KRTQEIVQD-------APSILDHLGV----------- aq_122 ------------NPLRVLDCKV-ETCKVAVRE-------APKMIDFLCD----------- TM1090 ------------NILRLLDCKV-DHEYSLN---------APKSVDYLCD----------- Rv2580c ------------NPLRVLDDKR-PELRAMTAS-------APVLLDHLSD----------- ML0494 ------------NPLRVLDDKR-PQVQAMTAA-------APVLLDHLSD----------- CT543 ------------NLLRILDSKE-PEDQEFIEK-------APSILDYIDD----------- CPn0663 ------------NVLRILDSKE-PEDQEIIRQ-------APPILDYVSD----------- MG035 ------------NPLRILDDKI-DQKKSFVKN-------APKITDFLDA----------- MPN045 ------------NPLRILDDKV-DGQLPFISD-------APQIEQFLDA----------- Cj0765c ------------NPIRVLDCKN-EHCQNLLEN-------APLLINNLCT----------- RP308 ------------NPMRILDSKS-EIDQKIIAH-------APILSEYHTN----------- DR1349 ------------NPMRILDSKS-ASDQELLAELS-----VRPMLDFLGEG---------- UU285 ------------NPLRILDDKL-ESQKLVVKQ-------APKISHFLSN----------- VNG2005G ------------DDLAAAGLSY-DQAEQFDDLLD-G-DDLDALVSFAGTDR---VR---- BB0135 -------------EALLLEIEK-EAVDSILSLVSLQ-GTFKDKIQALKSILG--DN---- TP0641 S---------LCDPVRVQKIMT-YVSAGEVDG------VAPSFEHTLSAIETLTGG---V XF2222 GQGFGIPAAQVENILTFVATRSTSHADALVRLDALIEDSGPEAHEMLR------------ APE0662 ------------RELERLGLPG-STVERIMEIISWR-GRPGEVLESVRRG--YGSN---- YPR033c ----------EMTEEKGQSEETADKIGEYVKLN----GSLKEIHAVLSADAN-ITSNEKA aq_1155 ------------NDIKFFVEVS--KNPEVLN----------FLEKYDLE----------- L0341 ------------NNFSKELRGLLKEIFITNELSR-----LENLVTNTKDD---------- mlr6929 ------------NPPRNGQLSG-EVAALVLDG------DLDGLSTHIAGG---------- CC3512 ------------DVAAPTGEQS--RIAALLAG----------LPEAEAA----------- TM1043 -------------HMKKIDLSRVEKIIEDSIYRR-----SPEHLKTMDLP---------- YDR283c_2 -----------ELKAQLNISSTALNDLELFDFRLDFEAAKKRLYKLMIDS----PHLKKI MJ1000 PKSMEAINNLEEILEFVIH---DKYTINLGIARGLDYYTG-MVFEIYG------------ MTH244 SESLEALEEFRELVETLHYFGVDDYHVNLGIARGLDYYTG-IVFEIYV------------ AF1642 -YDFGHLESLSALLRDVGV----DFTLNLGIARGLDYYTG-VVFECYA------------ PH0290 KEEISKLYKLTDLLEWYGVK--DWIRIDLGIARGFDYYTS-IVFEAIS------------ PAB1100 KEEISRLYNLVDILSWYEVD--EWIQIDLGIARGFDYYTS-IVFEAIV------------ Ta0099 SEEIARMAAVEDLLASYGVK---NVRYDFSIVRGLSYYTG-IVFEAYD------------ TVN0154 SKAAERLIRTIDILKEYGVK---SVKYDFSIVRGLSYYTG-LVFEAYD------------ mlr6928 QEGVGELATIEALVRAAGYGE-DRIAMDRSVVRGLEYYTG-PVFEAELLAEI-------- CC3513 DEGLLELSRIDAALSSLGIAD-DQAFIDPSIVRGLEYYTG-AVFEAELLLST-------- jhp1115 KKGIQDLERLYQLLGDLQISQ-NLYKIDFSIARGLGYYTG-IVYETTL------------ HP1190 KKGIQDLERLYQLLGDLQISQ-NLYKIDFSIARGLGYYTG-IVYETTL------------ hisS -ESREHFAGLCKLLESAGIA----YTVNQRLVRGLDYYNR-TVFEWVT------------ ZhisS -ESREHFAGLCKLLESAGIA----YTVNQRLVRGLDYYNR-TVFEWVT------------ VC0760 -ESKQHFAGLCELLDAAGIE----YTVNQRLVRGLDYYNR-TVFEWIT------------ HI0369 -ESRTHFEQLCSLLDAVGIQ----YEINPKLVRGLDYYNK-TVFEWVT------------ PM2011 -DSREHFAQLCALLDAVGIQ----YEVNPKLVRGLDYYNK-TVFEWVT------------ PA3802 -ESIAHFEGLKARLDAVGLR----YEINQKLVRGLDYYCR-TAFEWVT------------ NMB0854 -DSQNHYVRFKAMLDGLGIQ----YIENPRLVRGLDYYNQ-TVFEWTT------------ NMA1065 -ASQNHYARFKAMLDGLGIQ----YIENPRLVRGLDYYNQ-TVFEWTT------------ BU288 -SENNHFKNLCNMMNHHGIK----YKCNPHLVRGLDYYNS-TVFEWKS------------ BS_hisS -ESAAYFEKVKQYLNDLGIS----YEIDPNLVRGLDYYNH-TAFEIMS------------ BH1251 -ESKAYFEKVQSYLTALNIP----FVVDATLVRGLDYYNH-TAFEVMV------------ L0342 -ASKAYFEEVKALLEALHIE----YTIDPNMVRGLDYYND-TIFEFIV------------ SPy2157 -ESQAHFEAVKDMLEALDIP----YVIDTNMVRGLDYYSH-TIFEFIT------------ slr0357 -DSQRHFDQVQQLLTNLGIA----YQLTPTLVRGLDYYTH-TAFEIQS------------ aq_122 -ECREHYEKLKNYLKALDIP----FRENYNLVRGLDYYTR-TVFEAVS------------ TM1090 -SCRAHYKKLKEYLNTFEIE----YVEDHTLVRGLDYYTR-TVFEVRH------------ Rv2580c -VAKQHFDTVLAHLDALGVP----YVINPRMVRGLDYYTK-TAFEFVH------------ ML0494 -GAKQHFDTVLAHLDALRVP----YVINPRMVRGLDYYTK-TTFEFVH------------ CT543 -RDLSYFDAVLAQLKALGIS----FAINPRLVRGLDYYTD-LVFEAVT------------ CPn0663 -EDLKYFNEILDALRVLEIP----YAINPRLVRGLDYYSD-LVFEATT------------ MG035 -SAKQDSELLKTQLKKHNIS----FEWTDNLVRGLDYYTG-FVFEYVK------------ MPN045 -EQQALNTWLQQQLTQQQVP----FEWNPTLVRGLDYYTG-VVFEFVK------------ Cj0765c -SCQKDFETLQQILKDNGVK----FELDSKLVRGLDYYSK-TAFEFIS------------ RP308 -ESKKYFDELQKYLDILGIK----YSVNPRLVRGLDYYCH-TVFEFTT------------ DR1349 --AAADFRQVQAYLSDWGVP----FDLDPSIVRGLDYYRR-TAWELHY------------ UU285 -EEKEEFNLIKKMLDDYNIK----YYVNEGLVRGLDYYSG-LVFEFISTSP--------- VNG2005G -DAVANLRNVLDAAETLGVR--QYCDVSLTTARGLDYYTG-VVFECFD------------ BB0135 -ESIKRVEDVFQHLSLLKIQDS--FNLNLKISRGLDYYTG-IVFESEVFG---------- TP0641 SEESTRLRKIYELLCAVNIQS--SYVFDPSITRGFDYYTG-MVCETFL------------ XF2222 -QGVAELREVLTLVNVLGVP-EHAYRLNFSIARGLDYYTG-TVYETSL------------ APE0662 EKVREALDHLEEMLSLADDK---RVELDMSLVRGLDYYTG-PILEVVL------------ YPR033c KQGLDDIATLMKYTEAFDIDS--FISFDLSLARGLDYYTG-LIYEVVTSASAPPENASEL aq_1155 -KEKEELLELGKLLEEFGID----YAYDLGEVRNFPYYTG-VIFEIYE------------ L0341 -VLISSFDQLKEFSEKLSMIKP--IIIDLGMVPKMDYYTD-LMFKAYS------------ mlr6929 -MEQAGLSASAGRSPTDIAR----RLIEKAELRSVRLSNE-AFAALKN------------ CC3512 -SVLQELWSLAGIEPVGGRRP---AEIARRLVEKADAAKA-GRLDPAQ------------ TM1043 LSVREDLLSASSFLQEKFPTVS--VEIDLTLARTIEEYCG-LIFTIYD------------ YDR283c_2 EDSLSHISKVLSYLKPLEVAR--NVVISPLSNYNSAFYKGGIMFHAVY------------ MJ1000 ------KKG------AKQICGGGRYDNLIETFGG------EPT-PAVGFAYGFDRIM--M MTH244 ------PELG----AQKQICGGGTYN-LVETFGG------ERV-ESTGFAFGFDRLMNAL AF1642 ------EGLG----AQKQVCGGGSYE-LSSLFGG------PVT-PSTGFAIGFDRVCEAC PH0290 ------PNEL----GIGSIGGGGRYDNLIEIFGG------KPT-PATGFAIGIERLLPIL PAB1100 ------PNDL----GIGSIGGGGRYDNLIEVFGG------KPT-PATGFAIGIERLIPIL Ta0099 ------RSG-----QFRAILGGGRYDNLASLMSG------ESV-PAVGFGMGDAVISLLL TVN0154 ------KSG-----QFRAILGGGRYDNLAKLFSE------QDI-PAVGFGMGDAVISLLL mlr6928 ------PNEDGQIVRFGSVGGGGRYDGLVSRFRG------EPV-PATGFSIGVSRLMTAL CC3513 ------TDEKGNKVSFGSIGGGGRYDDLVARFTG------NVT-PATGFSFGVSRLAAAL jhp1115 -------ND---MKSLGSVCSGGRYDHLTKNFSK------ENL-QGVGASIGIDRLIVAL HP1190 -------NE---MKSLGSVCSGGRYDHLTKNFSK------ENL-QGVGASIGIDRLIVAL hisS ------NSLG----SQGTVCAGGRYDGLVEQLGG------RAT-PAVGFAMGLERLVLLV ZhisS ------NSLG----SQGTVCAGGRYDGLVEQLGG------RAT-PAVGFAMGLERLVLLV VC0760 ------ESLG----SQGTVCGGGRYDGLVEQLGG------KPT-PAVGFAMGLERLVLMM HI0369 ------SALG----AQGTVCGGGRYDGLVEQLGG------HAT-PSIGFAMGLERLVLLV PM2011 ------SALG----AQGTVCGGGRYDGLVEQLGG------HAT-TGVGFAMGLERLVLLV PA3802 ------DKLG----AQGTVCGGGRYDGLVSQFGG------KPT-PGVGFAMGVERLVLLL NMB0854 ------DKLG----AQATVCGGGRYDGLIEELGG------KPA-PSIGFAMGIERLLLLV NMA1065 ------DKLG----AQATVCGGGRYDGLIEELGG------KPA-PSIGFAMGIERLLLLV BU288 ------NKLG----AQNTICAGGRYDSLVQEMGG------RKT-PAIGFAIGIERLVLLV BS_hisS ------NAEG--FGAITTLAGGGRYDGLVEQIGG------PEA-PGIGFAMSIERLLAAI BH1251 ------DGEG--FGAITTLCGGGRYNGLVEEIGG------PET-PGIGFALSIERAIMAL L0342 ------DFD----GKDLTVCGGGRYDGLVEYFDG------PAT-PAFGFGLGIERLLMIA SPy2157 ------SVE----GSDLTICAGGRYDSLVGYFGG------PET-PGFGFGLGLERLLMII slr0357 ------SDL----GAQATVCGGGRYDGLVAELGG------PVT-PAVGWAMGLERLIILL aq_122 ------DELG-----LTLIAGG-RYDYLVEELGG------PPT-PALGFALGVERLMLLL TM1090 ------EGLGA----QSAIAGGGRYDGLFAELGG------SSV-PALGFAGGIERIILAL Rv2580c ------DGLG----AQSGIGGGGRYDGLMHQLGG------QDL-SGIGFGLGVDRTVLAL ML0494 ------PGLG----AQSGIGGGGRYDGLMRQLGG------QDL-SGIGFGLGVDRTLLAL CT543 ------VVGE----HSYALGGGGRYDELVAQSGG------PSM-PAFGFGVGLERVIQTL CPn0663 ------TFQE----VSYALGGGGRYDGLISAFGG------ASL-PACGFGVGLERAIQTL MG035 ------NQD--------TILAGGVYDNLVEELSS------NPT-PALGFACGIERLINCL MPN045 ------DDT--------TVLAGGVYDNLVEELGG------TPT-KALGFACGIERSINCL Cj0765c ------DEIG----AKAAIAGGGRYDRLIEYLGG------KSG-YGIGFAMGIERIITIL RP308 ------KKLG----SQSTILAGGRYDMLSRIMGN------YDV-HAIGFAAGIERIALMR DR1349 ------EGIG----AKSALGGGGRYDGLSEQLGG------GSV-PGIGWAFGVERLLLAL UU285 ------KLLG-----QSTIIGGGRYGELIKQTGG------PNY-EGIGFGIGIERLLIAL VNG2005G -------STG---DVGRAVFGGGRYDDLIERFGG------QPT-PAVGVAPGHATLNLLL BB0135 ------SNMG-------SVCSGGRYDNLVSSFSNSI----QKI-SGVGGSFGVDRIKDII TP0641 ------TQLP----HIGSVCSGGRYDHLTALYMK------DAV-SGVGASIGLDRLYAAF XF2222 ------INHP----QIGSICSGGRYENLANHYTQ------SKL-PGVGISIGLTRLFWQL APE0662 ------DEP-----RIGSVAGGGRYDGLVGMFAG------RDI-PATGVSIGIERIIDAG YPR033c KKKAKSAEDASEFVGVGSIAAGGRYDNLVNMFSEASGKKSTQI-PCVGISFGVERIFSLI aq_1155 ------LKSG------KALAGGGRYDNLSKIYGK-------EY-PATGGAVYLERLLDIL L0341 ------SAAN------QPILSGGRYDQLLSNFQE-------EA-FAIGFCCHMDTILKAL mlr6929 -----------------FLAIHVPLDGAARALET-------FA-AGAGLSLGAALEKFAA CC3512 -----ADKVR------AFLAVSDRPDAALSAIAALAG---PKA-EALNAVLDGWRARLAG TM1043 ------TSSS------RLVAAGGEYTVNGEKGVG-----------GSIFLEGKTC----- YDR283c_2 ------DDGS----SRNMIAAGGRYDTLISFFARPSGKKSSNTRKAVGFNLAWETIFGIA : MJ1000 N--------------IDDL-DIEE---ES---ILIIPVKKDKE-LI-------------- MTH244 G--------------MDEE-NMRM---VD---VFVIPIQDS---TV-------------- AF1642 S--------------VEAG-EKSV---VA---VVSFKGLES------------------- PH0290 E--------------WKGL-IPKP---QTGPEVFVIPLKDM----E-------------- PAB1100 E--------------WKGL-LPEL---KAGPDVFVIPVGDS----R-------------- Ta0099 K--------------RENV-QIPR---EK-KSVYICRVGKIN---S-------------- TVN0154 K--------------SKGV-KAPH---AK-KSVYVCRVGTVK---A-------------- mlr6928 K--------------NLGK-LDNA---DVIAPVVVLVMDKDTE-SL-------------- CC3513 R--------------AAGR-EPGG---AARGPVVVITFDQ--A-HM-------------- jhp1115 S--------------EMQL-LDER---STQAKVLIACMHE--E-YF-------------- HP1190 S--------------EMQL-LDER---STQAKVLIACMHE--E-YF-------------- hisS Q--------------AVNP-EFKA---DPVVDIYLVASGAD---TQ-------------- ZhisS Q--------------AVNP-EFKA---DPVVDIYLVASGAD---TQ-------------- VC0760 E--------------TLG--NTDV---RRSVDVYMVTAGEG---TM-------------- HI0369 Q--------------EVNP-NVPA---KSAVDIYVVYQGEG---AT-------------- PM2011 Q--------------EVNQ-SIRL---PSAVDIYVVYQGEG---TT-------------- PA3802 E--------------TLGVIPAEL---NRPADLYVCAFGEP---AE-------------- NMB0854 S--------------EYG--SLEV---NAAPDVYAMHQGEG---AD-------------- NMA1065 S--------------EYG--SLEV---NAAPDVYAMHQGEG---AD-------------- BU288 K--------------SLKI-FSEV---IEESNVYIIFIGDN---NK-------------- BS_hisS D--------------AEKR-ELPV---DKGIDCYIVTLGEK---AK-------------- BH1251 E--------------AQQA-KPAH---NQAIDCYVVTLGEA---AK-------------- L0342 Q--------------KQEI-NFIP---EETLDVYIAVMGEK---AN-------------- SPy2157 E--------------KQGI-TLPI---ETEMDIYLAVLGDG---AN-------------- slr0357 ----------------QQM-ATPP---APSPDLYLISKGEK---AE-------------- aq_122 P--------------DE----------EEKEEVYFVIPFGD---VH-------------- TM1090 K--------------AEGI-EIPM---KNVHLVYIATLGEK---AF-------------- Rv2580c R--------------AEGK-TAGD---SARCDVFGVPLGEA---AK-------------- ML0494 H--------------AEGK-TVGE---TTRCDVFGVSLGEA---AK-------------- CT543 L--------------EQG--NSLS---TSTRRLRLIPMDEQ---AD-------------- CPn0663 L--------------AQK--RIEP---QFPHKLRLIPMEPD---AD-------------- MG035 E--------------IDKKAFILN---TKPKQMLVICLFEE---AL-------------- MPN045 S--------------AVKKQAILA---NQPPRLLVIGLTEA---AL-------------- Cj0765c E--------------QKE----EK---IQREGIYLCAMDEI---YI-------------- RP308 E--------------YK------I---SVIKPVFVLPIGKN---NI-------------- DR1349 E--------------QEGI-EIPG---SGGPQLYVAALDEE---NV-------------- UU285 S--------------ETN--KNIL---NTDDDKYLIAFFDK-E-LE-------------- VNG2005G E--------------NAGV-LPDD---EFTPDYYVLQVGDT----D-------------- BB0135 D--------------LEKFSYIKIFVTKARSKVLIVNLDSA---LQ-------------- TP0641 Q--------------QLGM-SREH---VCFVQALIFCQDSA---LM-------------- XF2222 R--------------DAGVMDGIA---ESSVQAMVVLMDEA---TL-------------- APE0662 L--------------ELGVYSLDV---KTVAQVAVVVLDRR---YY-------------- YPR033c K--------------QRINSSTTIKPTATQVFVMAFGGGKDWTGYL-------------- aq_1155 P--------------KN----------VEKKDYFVIDKTKK------------------- L0341 E--------------RQELEEDND------------------------------------ mlr6929 R--------------AKAIEAHGL---PAEKIRYDAAFGRP----L-------------- CC3512 M--------------AQRG--V-----ALERATLAAAFGRA----F-------------- TM1043 ------------------------------------------------------------ YDR283c_2 QNYFKLASGNRIKKRNRFLKDTAVDWKPSRCDVLISSFSNSLLDTIGVTILNTLWKQNIK MJ1000 -----------------------------KKSLIIADKLRK------AGKIVELEIMGR- MTH244 -----------------------------PEAIRITQELRA------AGVSADLEVSGR- AF1642 ------------------------------QAFRVASMLRE------RGFTAVVDVMGR- PH0290 -----------------------------KVAINIAVKLRR------EKIKTDIELSGR- PAB1100 -----------------------------DVATAIVTRLRK------AGIRSDIELSGR- Ta0099 -----------------------------SIMNEYSRKLRE------RGMNVTVEIMER- TVN0154 -----------------------------ERIASISKMLRS------SGFIVSAEIMDR- mlr6928 -----------------------------GRYQKMVSELRA------AGIRSEMYLGGA- CC3513 -----------------------------GEYFSVVGQLRA------AGIAAEVYLGTS- jhp1115 -----------------------------SYANRLAESLRQ------SGIFSEVYPEAQ- HP1190 -----------------------------SYANRLAESLRQ------SGIFSEVYPEAQ- hisS -----------------------------SAAMALAERLRDE----LPGVKLMTNHGGG- ZhisS -----------------------------SAAMALAERLRDE----LPGVKLMTNHGGG- VC0760 -----------------------------MAGMKLAEQLREQ----VPGLRVMTHFGGG- HI0369 -----------------------------LAAFELAEKVRSE----LPHLNTMLHCSSG- PM2011 -----------------------------LAAFQLAETLRTE----LPQLRVMTHCSGG- PA3802 -----------------------------LAALTLAEQLRSA----IPGIRLLVNAGAG- NMB0854 -----------------------------LQVMKYAQALR------AQGFNVMQHSGYQ- NMA1065 -----------------------------LQVMKYAQALR------AQGFNVMQHSGYQ- BU288 -----------------------------CHAINLSEEIRDL----YPKLRIFINFLHQ- BS_hisS -----------------------------DYSVSLVYKLRE------AGISSEIDYENK- BH1251 -----------------------------DKGVELVYQLRN------AGISAEKDYLDR- L0342 -----------------------------LEATKLAESLRE------QAFKVERDFSNR- SPy2157 -----------------------------SKALELVQAIRR------QGFTAERDYLGR- slr0357 -----------------------------PQALILAQKLRN------QGLAVALDLSAS- aq_122 -----------------------------EYALRVADILRK------KGKVVEYSYRKG- TM1090 -----------------------------MDGVRLAGELRK------KGLSVDVDIMDR- Rv2580c -----------------------------LRLAVLAGRLRA------AGVRVDLAYGDR- ML0494 -----------------------------LKVAMLAGQLRA------AGVRVDLIYGDR- CT543 -----------------------------AFCFSWANRLRN------LGIATEVDWSHK- CPn0663 -----------------------------QFCLEWSQHLRR------LGIPTEVDWSHK- MG035 -----------------------------EELVWLAKLWR-------EYNQVTIYPKVI- MPN045 -----------------------------EKLLQLSLGWR-------AYHPVTIYPKVI- Cj0765c -----------------------------QKLLHIATNLR-------KEYKVLLSYEAR- RP308 -----------------------------CYALDIVDKLR------LQNIVSIIDPIG-- DR1349 -----------------------------PLAARVALAAR-------ASCRAEFAYRAM- UU285 -----------------------------NEAIKLTQILRIN-----NQLNVDIILSST- VNG2005G -----------------------------AEAADVASALRE------RGNRVDTDITGR- BB0135 -----------------------------NYYYELATRFRNHDYSKVKNISCEVYFKNKN TP0641 -----------------------------DVYQKLCSYFA-------VQVATEVFPDPR- XF2222 -----------------------------DDALDIARCLR------IGGINTEVQMEAK- APE0662 -----------------------------RYAWEAARILRR------GGLNVRIDLSRA- YPR033c -----------------------------PERMKVTKQLWD------AGIEAEYVYKAK- aq_1155 -----------------------------RLGLKLADVLRE------KGKKVGMEIVKE- L0341 ------------------------------------------------------------ mlr6929 -----------------------------DYYTGVVFEIAA------QGGERPLAGGGR- CC3512 -----------------------------GYYDGYLFEIRSAS----LGDERPVAAGGR- TM1043 ------------------------------------------------------------ YDR283c_2 ADMLRDCSSVDDVVTGAQQDGIDWILLIKQQAYPLTNHKRKYKPLKIKKLSTNVDIDLDL MJ1000 ---KLRKALDYANSRGFKKVIIVGEKE----------------------------LNEGK MTH244 ---KLRKALSHADNLGARFAVLTGERE----------------------------IQDGK AF1642 ---NLKKQMSFASEMGVKYAVILGPDE----------------------------VKSGR PH0290 ---KLGKALDYANRVGAKLVIIVGKRD----------------------------VERGV PAB1100 ---KLRKALDYANRIGVRLSIIVGKRD----------------------------LERGV Ta0099 ---GLSAQLKYASAIGADFAVIFGERD----------------------------LERGV TVN0154 ---SLSSQLKYASYEGCEYAVIAGERD----------------------------LENNS mlr6928 ---GMKAQLKYADRRGCPVAIIQGGDE----------------------------RAKGE CC3513 ---GMKPQMKYADRRGAPAVVMLGGDE----------------------------IAAGT jhp1115 ---KIKKPFSYANHKGHEFVAVIGEEE----------------------------FKSET HP1190 ---KIKKPFSYANHKGHEFVAVIGEEE----------------------------FKSET hisS ---NFKKQFARADKWGARVAVVLGESE----------------------------VANGT ZhisS ---NFKKQFARADKWGARVAVVLGESE----------------------------VANGT VC0760 ---NFKKQFKRADKVGAAIALVLGEDE----------------------------VAAQT HI0369 ---NFKKQFKRADKSGATLALVIGESE----------------------------VQNKQ PM2011 ---NFKKQFKRADKSGATLALVIGESE----------------------------VQNQQ PA3802 ---SFKSQFKKADKSGARFALILGEDE----------------------------VANRV NMB0854 ---SLKAQMKKADNSGARFALIVAQDE----------------------------LANGT NMA1065 ---SLKAQMKKADNSGARFALIVAQDE----------------------------LANGT BU288 ---NLTKKIKNAISSLARIIILIGDNE----------------------------IKKGF BS_hisS ---KMKGQFKTADRLKARFIAILGEDE----------------------------LAQNK BH1251 ---KMKGQLKAADRLHAKWTVILGEDE----------------------------LAVGK L0342 ---KLGAQFKTAEKLGAELIITLGEDE----------------------------IRTGQ SPy2157 ---KIKAQFKSADTFKAKLVMTLGESE----------------------------VEAGK slr0357 ---AFGKQFKRADKSGAIACLVLGDGE----------------------------IATGT aq_122 ---GLKKQLEFADKLGVKYAVIIGEDE----------------------------VKNQE TM1090 ---KLSGQLKHASRMGSRYAVIIGDEE----------------------------LEKGI Rv2580c ---GLKGAMRAAARSGARVALVAGDRD----------------------------IEAGT ML0494 ---GIRGAMRAAGRSGARIALIVDDCA----------------------------IKADG CT543 ---KPKLSLKDAADQQVSFVCLLGEQE----------------------------LATKQ CPn0663 ---KVKGALKAASTEQVSFVCLIGERE----------------------------LISQQ MG035 ---KVDNGIRLANRLGYTFIGIVGKTD----------------------------FDKKA MPN045 ---RIINGIRAAQRLGYRFLGVIGGNN----------------------------LEQQT Cj0765c ---KLAKHLENADKNNTEIFLCMGENE----------------------------AQNES RP308 ---KIAKRIQRVLNEDAKFIIFIGDEE----------------------------KMNNN DR1349 ---KPGSAFKDAERRGAVWVGLIGSEE----------------------------AAAGT UU285 ---KADKIFKLAQRLNVKKLIILAKKE----------------------------WSDKK VNG2005G ---SFGAQMNYADNVGADTVVIVGEQD----------------------------LADGN BB0135 -GKNIKEQIEYALSKEIRFLVFVGQEE----------------------------YKENK TP0641 ---KLSQQYAFAEKKGIRWGIFVEQRNAV--------------------------VEDCL XF2222 ---KVSKQFQYASRAGIRFVVLAGDDE----------------------------RARGV APE0662 ---SGQVQRRKASRLGIPVLAFVGAKE----------------------------AEGGF YPR033c --ANPRKQFDAAEKAGCHIAVILGKEE----------------------------YLEGK aq_1155 --RGLEHSLIYAFDKGFKEVLLVEDEI----------------------------VKVYT L0341 ------------------------------------------------------------ mlr6929 --YDRLLTLLGAKTAIPGVGFSVWLDR----------------------------IEALR CC3512 -YDGLPAKLGVATDTGAVGFMIRPARA----------------------------YAGGG TM1043 ------------------------------------------------------------ YDR283c_2 DEFLTLYQQETGNKSLINDSLTLGDKADEFKRWDENSSAGSSQEGDIDDVVAGSTNNQKV MJ1000 VTVKDMITG-----E-----------------------QKLIGIDELTNF---------- MTH244 VTVKDMERN-----S-----------------------QETLPRDEMVDKIKGRC----- AF1642 VAIKNLETQ-----E-----------------------QVVVAEEELFSILQ-------- PH0290 VTIRDMESG-----E-----------------------QYNVSLNEIVDKVKNLLKR--- PAB1100 VTIRDLESG-----N-----------------------QVEVPVDNVVTKVRELLNQ--- Ta0099 VTIRNMYTG-----S-----------------------QENVGLDSVVEHLISQAT---- TVN0154 VTVRDLSTG-----E-----------------------QEIVTLGDLVPFLEKSTSY--- mlr6928 LQIKDLIEGARMSAE----------ITDNAEWRAARPAQVTVAESELVAEVKKILAAQAE CC3513 VTIKDLDAG-RMAAEG---------LTDNAAWKAERPGQQTIPRDQLVDAVRKIIGG--- jhp1115 LSLKNMHSG--MQLN-----------CL-SFLKAL---EIIGENDEDL------------ HP1190 LSLKNMHSG--MQLN-----------CL-SFLKAL---EIIGENDEDL------------ hisS AVVKDLRSG----------------------------EQTAVAQDSVAAHLRTLLG---- ZhisS AVVKDLRSG----------------------------EQTAVAQDSVAAHLRTLLG---- VC0760 VVVKDLAGG----------------------------EQNTVAQAEVAKLLAHLA----- HI0369 VVVKHLQGGT---------------------------DQQTLDLVNIIDYLQTQF----- PM2011 VVVKHLLGGA---------------------------EQQTLALDDIVDYIKNNF----- PA3802 VGFKPLRDEG---------------------------EQQSIAWDALPEHLAACLAQA-- NMB0854 VTLKDMNGAH---------------------------GQQTVAAEDLTPTLQQWKNA--- NMA1065 VTLKDMNGAH---------------------------DQQTVAAADLTNTLQQWKNA--- BU288 FLVKDLKEK----------------------------KEYHLLKKELILKIQEIFK---- BS_hisS INVKDAQTG----------------------------EQIEVALDEFIHVMKANQKG--- BH1251 VNVKNMETG----------------------------EQTDVALTDLVSHMKQQVEGGNE L0342 IKVKHNQTR----------------------------KQVETTLKAVHESFAPIFEEIYA SPy2157 AVIKNNRSR----------------------------QEVEVSFEDMMTNFANISEQLLS slr0357 VQLKWLADK----------------------------AQETLQLQDLMGNITELKQRLAG aq_122 VTIKDMETG----------------------------EQRRVKLSEL------------- TM1090 VILRDLETG----------------------------DQVEIDRDFAADYIAERVSKD-- Rv2580c VAVKDLTTG----------------------------EQVSVSMDSVVAEVISRLAG--- ML0494 VGVRDLATG----------------------------EQISVAVDSVVAEVISRIAPS-- CT543 FIVKDMSLH----------------------------QSFSGAQQDVEQRLVYEVQNA-- CPn0663 LVIKNMSLR----------------------------KEFFGTKEEVEQRLLYEIQNTPL MG035 ITIKNLVSK----------------------------QQTIYTWNELGERNVF------- MPN045 ITVKDLATE----------------------------QQTTYTWDEFRQRQVL------- Cj0765c LFYKNLAKK----------------------------EEKMIKISDLKKVL--------- RP308 LKFKDLKNQ----------------------------KEYIIDFEKVLELLKQ------- DR1349 LSLKNLHTG----------------------------EQKTVPVGELGQALA-------- UU285 IILKDLLNF----------------------------KQDLLSLDEIKGIR--------- VNG2005G VTIKNMASG----------------------------EQTTAPIAAFPGAHDAPRVEDFA BB0135 MKVRDLTKK----------------------------EELLLSFEESINLIKCNEKLLCT TP0641 LVLRDLSTR----------------------------KDTRLPAHEVRRRMAAEG----- XF2222 VAVKDLTRE----------------------------QQFEIPREELASTLQVELEQAKV APE0662 LTLYSAAKG----------------------------ERVAVPLGEAVKAVERLLPS--- YPR033c LRVKRLGQEFADD------------------------DGELVSAADIVPIVQEKLSQIHE aq_1155 TPKDYVVMK----------------------------------IREFLDLIE-------- L0341 ------------------------------------------------------------ mlr6929 EAAP-------------------------------------------------------- CC3512 E----------------------------------------------------------- TM1043 ------------------------------------------------------------ YDR283c_2 IYVPNMATRSKKANKREKWVYEDAARNSSNMILHNLSNAPIITVDALRDETLEIISITSL MJ1000 ---------------------------------------------------------- MTH244 ---------------------------------------------------------- AF1642 ---------------------------------------------------------- PH0290 ---------------------------------------------------------- PAB1100 ---------------------------------------------------------- Ta0099 ---------------------------------------------------------- TVN0154 ---------------------------------------------------------- mlr6928 ERARGK---------------------------------------------------- CC3513 ---------------------------------------------------------- jhp1115 ---------------------------------------------------------- HP1190 ---------------------------------------------------------- hisS ---------------------------------------------------------- ZhisS ---------------------------------------------------------- VC0760 ---------------------------------------------------------- HI0369 ---------------------------------------------------------- PM2011 ---------------------------------------------------------- PA3802 ---------------------------------------------------------- NMB0854 ---------------------------------------------------------- NMA1065 ---------------------------------------------------------- BU288 ---------------------------------------------------------- BS_hisS ---------------------------------------------------------- BH1251 S--------------------------------------------------------- L0342 DEEL------------------------------------------------------ SPy2157 ---------------------------------------------------------- slr0357 HREKYPHLTSNFSVTCHDPMDNLV---------------------------------- aq_122 ---------------------------------------------------------- TM1090 ---------------------------------------------------------- Rv2580c ---------------------------------------------------------- ML0494 ---------------------------------------------------------- CT543 ---------------------------------------------------------- CPn0663 ---------------------------------------------------------- MG035 ---------------------------------------------------------- MPN045 ---------------------------------------------------------- Cj0765c ---------------------------------------------------------- RP308 ---------------------------------------------------------- DR1349 ---------------------------------------------------------- UU285 ---------------------------------------------------------- VNG2005G ---------------------------------------------------------- BB0135 PF-------------------------------------------------------- TP0641 ---------------------------------------------------------- XF2222 M--------------------------------------------------------- APE0662 ---------------------------------------------------------- YPR033c DGLNEVTRLIKGL--------------------------------------------- aq_1155 ---------------------------------------------------------- L0341 ---------------------------------------------------------- mlr6929 ---------------------------------------------------------- CC3512 ---------------------------------------------------------- TM1043 ---------------------------------------------------------- YDR283c_2 AQKEEWLRKVFGSGNNSTPRSFATSIYNNLSKEAHKGNRWAILYCHKTGKSSVIDLQR