CLUSTAL W (1.74) multiple sequence alignment AF2116 -----------MLQLNSPHVHNLFNTPFSAAIMDDVVIGLEVHVQLNRLRTKLFCSCPLN VNG0345G ------------------------MSAQAAERDLTAIIGLEVHVQL-ETDTKIFCGCSTD MJ0160 --------------------------MGGNMEDVKMKCGLEIHVQI-DTKSKLFCNCSTN MTH1280 -----------------------------------MKCGLEIHVQL-DTRSKLFCRCPTD aq_461 -----------------------------MNEKYEAVIGLEIHVQM-DTKTKMFCGCKVE TM1273 -------------------------------MRYRPVIGLEIHVQL-STKTKAFCSCPAD TP1021 --------MSDLQTGTVPSIAGATDDTHAAPFFYEVIIGCEIHCQL-LTKTKAFCACAN- BB0341 -------------------------------MEYKLVIGLEIHVQL-GLKTKAFCGCKN- MG100 ------------------------------MINFEAIIGIEVHVVL-NTASKMFSKAPNR MPN238 -----------------------------MMINFEAIIGIEVHVVL-NTATKMFSPAPNQ UU544 ------------------------------MQNFEVIIGIEVHTAL-NTKTKMFSNAAT- CT004 --------------------------MGIAHTEWESVIGLEVHVEL-NTESKLFSPARN- CPn0004 --------------------------MSAVYADWESVIGLEVHVEL-NTASKLFSSALN- BS_yerN ------------------------------------------------------------ BH0667 -------------------------------MNFETVIGLEVHVEL-KTESKIFSASPN- L0474 --------------------MTFLKKVSEKIMNFETVIGLEVHVEL-STNSKIFSPAST- SPy1770 -------------------------------MNFETIIGLEVHVEL-NTNSKIFSPSSA- sll1435 MREKSARWTAGVWQNGRKPICRKFMTATAVKTDYEAIIGLETHCQL-NTASKIFCNCST- NMB1358 -------------------------------MTWETVIGLEIHVQL-NTKSKIFSGAST- NMA1570 -------------------------------MTWETVIGLEIHVQL-NTKSKIFSGAST- PA4484 -------------------------------MQWETVIGLEIHAQL-ATQSKIFSGSST- jhp0603 -------------------------------MPFEAVIGLEVHVQL-NTKTKIFCSCST- HP0658 ------------------------------MMPFEAVIGLEVHVQL-NTKTKIFCSCST- Cj1197c --------------------------------MFEVVIGLEVHAQL-NTKTKIFCSCAT- mlr0190 ------------MTIIDTRTPDAKRLIPGATGDWEIIIGLEVHAQV-ISEAKLFSGAST- CC2436 ---------------MNENT----KVIKGRTGDWEMVLGLEVHAQV-ASKSKLFSGAAV- RP151 -----------------------MEYIEGNTGKWEYVIGLEIHAQI-SSKSKLFSGSST- Rv3009c ---------MTVAAGAAKAAGAELLDYDEVVARFQPVLGLEVHVEL-STATKMFCGCTT- ML1700 ---------MTVVSGASKASGADLLDYDVVVARFDPVFGLEVHVEL-STVTKMFCGCAT- DR2555 MRACVLLSCLPRCRCLPALQMRSGQGAILFPMTYQAVIGLEVHLQL-NTRSKIFSACPAD APE1718 ----------------------------MNDRYTNVKIGLEIHVQLSNAGSKLFCGCDSE YBL080c -------MLRLARFYSLARTKAIHSHGAPFRPEYALKCGLEIHTQL-NTKNKLFSQSTNS DR2611_2 ------------------------------------------------------------ AF2116 Y--HQSPPNTHVCPVCLGMPGAMPV-INKEAVKAAVKVAMALNAEIQ--PFTVFDRKNYF VNG0345G T--DDADPNTHTCPVCLGLPGALPT-LNEGAVEAAVKLGKAIDADIP--ERTRFHRKNYF MJ0160 Y--LDAEPNTNVCPVCLGLPGAKPLPPNKKAVEVAIMVAKMLGCKIVVDEDIYFQRKHYD MTH1280 Y--QEAPPNTNICPVCLNQPGAKPYPPNRSALEGALKIALMLDCRIN-PEITYFMRKHYN aq_461 ---FGAEPNTNVCPVCLGMPGALPI-VNKRAVEYAIRASLALNCEVH--EESVFARKHYF TM1273 V--FELPPNTAICPVCTGQPGALPV-PNEEMIRFAVKTALALNCKIH--KYSRFDRKNYF TP1021 R--SGGMPNSRVCPVCLGLPGALPV-VSEEYVRLGVRAGLALGC-TIQ-LWSAFDRKHYF BB0341 E--FGGVPNSRVCPICLGLPGSLPS-VNVELINSAILAGHATNS-KIR-NVVKFDRKHYY MG100 V--DNQKINHFIDPIDLGLPGTLPQ-VNELAVYKALLLADALKMKTVT-NKLVFDRKHYF MPN238 A--QNATPNQFINAIDLGLPGTMPQ-VNEQAVQKALILADALNMQRVQ-PVLVFDRKHYF UU544 S--HKSIPNTLINEIDLALPGTLPT-VNQEVVHKGLFLANALHMRTNH-QFIAFDRKHYY CT004 H--FGDEPNTNISPVCTGMPGSLPV-LNKDAVRKAVLFGCAVEGDVA--LFSRFDRKSYF CPn0004 R--FGDEPNTNISTVCTGLPGSLPV-LNQSAVEKAVLFGCAVEGEIS--LLSRFDRKSYF BS_yerN -----------------------------------MKAAMALNCEIA--TDTKFDRKNYF BH0667 H--FGAEPNANTSVIDLGYPGVLPV-LNKAAVEFAMKAAMALNCEVA--TDTKFDRKNYF L0474 K--FGGDPNTNTNVIDWSLPGVLPV-MNKGVIDSGIKAALALNMDIH--KSMHFDRKNYF SPy1770 H--FGEDPNANTNVIDWSFPGVLPV-MNKGVIDAGIKAALALNMDIH--KEMHFDRKNYF sll1435 D--FDSPPNTNVCPVCLGYPGVLPV-LNEEVLAAAVKLGLAINGQIA--PYSKFDRKQYF NMB1358 A--FGAEPNAHASVVECALPGVLPV-MNREVVEKAIKLGLALDAKIN--QKNVFDRKNYF NMA1570 A--FGAEPNAHAGVVECALPGVLPV-MNREVVEKAIKLGLALDAKIN--RKNVFDRKNYF PA4484 A--FGAAPNTQASLVDLAMPGTLPV-LNEEAVRMACLFGLAIDARID--RQNVFARKNYF jhp0603 S--FGETPNSNTCPVCLGLPGALPV-LNKEVVKKAIQLGTAIEAHIN--QYSIFARKNYF HP0658 S--FGESPNSNTCPVCLGLPGALPV-LNKEVVKKAIQLGTAIEANIN--QYSIFARKNYF Cj1197c S--FGEAPNTNVCPTCLALPGALPV-LNEEAVKKAIAFGKAVNATIN--KKSVFNRKNYF mlr0190 A--FGAAPNANVSLVDAAMPGMLPV-INEECVKQAIRTGLGLKAQIN--HKSVFDRKNYF CC2436 G--FGAGPNEQVSLVDAAMPGMLPV-LNRFCVEQAVKTGLGLRAQIN--LKSRFDRKNYF RP151 L--FAASPNSQVSYVDAAMPGMLPV-LNKHCVYQAIKTGLVLKAKIN--KYSVFDRKNYF Rv3009c T--FGGEPNTQVCPVCLGLPGSLPV-LNRAAVESAIRIGLALNCEIV--PWCRFARKNYF ML1700 T--FGAEPNTQVCPVCLGLPGSLPV-LNRAAVQSAIRIGLALNCEIV--PWCRFARKNYF DR2555 Y--HGAGPNEFTDPLTLGLPGTLPT-LNRRAVELAMMFGLGLGCDVS--GFTQFHRKNYF APE1718 Y--RGYKPNTNVCPVCLGLPGALPV-PSRRPIVLAIAASMALGCRVP--GTVVFTRKHYF YBL080c ATSLVDAPNHHTSYYDIALPGTQPV-LNLEAILFAMKLSLALGSQVN--SISQFDRKHYF DR2611_2 ------------------------------------------------------------ AF2116 YPDLPKGFQISQYD----RPLALGGYVTIELDGQ------EKRIQLKRVHMEEDPGKLSY VNG0345G YPDLPKGFQITQYD----APICQDGELEVGTADD------RRAIGIERAHLEEDPGSLQH MJ0160 YPDLPSGYQRTS--------------TPIGVDGE------FMGIGIHEVHLEEDPG--QY MTH1280 YPDLPSGYQRTS--------------IPVGLEGE------LNGVRIREVHIEEDPG--QY aq_461 YPDLPKGYQISQYE----KPLATNGWVELNLPNGE-----KKKVRIRRLHIEEDAGKNIH TM1273 YPDLPKGYQISQYF----YPIATEGFLEIDGDEG------RKKVRIRRLHLEEDAGKLVH TP1021 YPDLPKGYQITQYD----APLCTDGAVDVQGVDMP----VQRRVRIERIHLEEDAGKSLH BB0341 YPDLPKGYQISQND----KPICEGGSLLIETPSGP------KKINIIRIHMEEDSGKSLH MG100 YQDLPKGFQITQQN----YPFAKNGVVTINVD--A----IEKPIYIDRFHLEEDTAK-QH MPN238 YQDLPKGFQITQQN----FPIAQNGYVEIVEN--N----KAQRIIIERFHLEEDTAK-QH UU544 YLDLPKGYQITQNY----FPIGQNGYIQIIDEY-N----NLKRIRIKQIHLEEDTAK-QT CT004 YPDSPRNFQITQYE----HPIVRGGCIRAVVEG------EEKTFELAQTHLEDDAGMLKH CPn0004 YPDSPRNFQITQFE----HPIIRGGRIKAIVQG------EERYFELAQTHIEDDAGMLKH BS_yerN YPDNPKAYQISQFD----KPIGENGWIEIEV------GGKTKRIGITRLHLEEDAGKLTH BH0667 YPDNPKAYQISQFD----KPIGENGWIEIEV------DGTKKKIGITRLHLEEDAGKLTH L0474 YPDNPKAYQISQFD----EPIGYNGSIEIELE-----DGHKATIRIERAHLEEDAGKNTH SPy1770 YPDNPKAYQISQFD----EPIGYNGWIDIKLE-----DGSTKKIRIERAHLEEDAGKNTH sll1435 YPDLPKNYQISQFD----LPIVEHGSLEIELVDKKTKEITRKTIGITRLHMEEDAGKLVH NMB1358 YPDLPKGYQISQLD----LPIVEHGKLEIVVGD------DVKTINVTRAHMEEDAGKSVH NMA1570 YPDLPKGYQISQLD----LPIVEHGKLEIVVGD------DVKTINVTRAHMEEDAGKSVH PA4484 YPDLPKGYQTSQMD----HPIVGKGHLDITLEDG-----TTKRIGITRAHLEEDAGKSLH jhp0603 YPDLPKAYQISQFE----VPIVSDGKLEIDTKE------GAKIVRIERAHMEEDAGKNIH HP0658 YPDLPKAYQISQFE----VPIVSDGKLEIDTKE------GAKIVRIERAHMEEDAGKNIH Cj1197c YPDLPKAYQISQFD----IPIVEKGELFINVKG------ENKRIGITRAHLEEDAGKNIH mlr0190 YPDLPQGYQISQFK----QPIVGEGTVIVSVGPDRQGEFEDIEVGIERLHLEQDAGKSMH CC2436 YPDLPQGYQISQFD----QPIVGEG--VVSVERD-DG--TTFDVRIERLHLEQDAGKSLH RP151 YADLPQGYQISQFY----YPIVQDG--MIEIPTS-TG--DLKTIRINRLHLEQDAGKSIH Rv3009c YPDMPKNYQISQYD----EPIAINGYLDAPLEDG-----TTWRVEIERAHMEEDTGKLTH ML1700 YPDVPKNYQISQYD----EPIAINGYLEVPLEDD-----TTWRVEIERAHMEEDTGKLTH DR2555 YPDAPKNFQLSQYD----RPIARDGYLDVPGEGG------PERIRIKRAHLEDDAGKLVH APE1718 YPDLPKNYQITQFEKAGGAPVCMGGVLEYLNTDS----WRWERARIRRINLEEDPGKTYY YBL080c YGDQPQGYQLTQHY----RPFARGGKINLSKELDD-IDESAKEIGILQLQIEQDTGKSHY DR2611_2 ------------------------------------------------------------ AF2116 KG-SI--TT-AKYSLIDYNRSGAPLLEIVTEP----VMNSPKEARLFLNKLRMILEYLEV VNG0345G VGGSI--ED-ADYTLVDYNRAGTPLMEIVTRP----DFRAAEEVRSFLAKLTSVLEYLGV MJ0160 NP--------S-FGIVDYNRSGTPLIEIVTKP----DIKSPEEAREFLKQLMTLFRYLGC MTH1280 KP--------D-QGTVDFNRSGIPLIEIVTEP----DMTSPEEARNFLRELIRVLEYSGC aq_461 EGD---------KTLVDLNRAGTPLMEIVTEP----DIRTPEEARLFLEKLRNIMRYAGV TM1273 EGDSI--TR-ASYSLVDMNRCGVPLIEIVTEP----DISSPREARVFMEKLRSIVRYLGV TP1021 AADA--------YSYIDFNRCGVPLIEIVSRP----DLRSAEEAACFMQTIREILTFIEV BB0341 LLDSE-----N-QSYVDFNRSGAPLLEIVSAP----DINSGDEAVAFLSSLREIFRYLDL MG100 FNHD--------QILLDFNRCGAPLIEVVTLP----VINTAKEAKAYLQKLRQILIVNNI MPN238 FVDG--------QILLDFNRCGAPLIEVVTAP----VIKSAKQSKAYLQKLRQILIVNNI UU544 NIGN--------QIYLDYNRAGWPLIEIVSEA----DLRSAQETVLFLEELRKILLFNDI CT004 FGD---------FAGVDYNRAGVPLIEIVSKP----CMFSAEDAVAYANALVSILGYIGI CPn0004 FGE---------FAGVDYNRAGVPLIEIVSKP----CMFCPEDAVAYATSLVSLLDYIGI BS_yerN TGDG--------YSLVDFNRQGTPLVEIVSEP----DIRTPEEAYAYLEKLKSIIQYTGV BH0667 SGNG--------YSLVDFNRQGTPLIEIVSEP----DIRTPQEAYAYLEKLKSIIQYTGV L0474 GTDG--------YSYVDLNRQGVPLIEIVSEA----DMRTPEEAYAYLTALKEAILYTGI SPy1770 GTDG--------YSYVDLNRQGVPLIEIVSEA----DMRSPEEAYAYLTALKEIIQYTGI sll1435 AGSDR--LAGSTHSLVDFNRTGVPLLEIVSEP----DLRTGQEAAEYAQSLRQLVRYLGI NMB1358 EGLN-------GATGIDLNRAGTPLLEVVSEP----EMRSAAEAVAYAKALHSLVTWLDI NMA1570 EGLN-------GATGIDLNRAGTPLLEVVSEP----EMRSAAEAVAYAKALHSLVTWLNI PA4484 EDFQ-------GMSGIDLNRAGTPLLEIVSEP----DIRSAKEAVAYVKAIHALVRYLGI jhp0603 EGS---------YSLVDLNRACTPLLEIVSKP----DMKNSEEAIAYLKKLHAIVRFIGI HP0658 EGS---------YSLVDLNRACTPLLEIVSKP----DMRNSEEAIAYLKKLHAIVRFIGI Cj1197c ESN---------FSKVDLNRAGTPLLEIVSEP----ELRSSDEAVAYLKKLHSIIRFLDI mlr0190 DQHP-------TMSYVDLNRSGVALMEIVSKP----DLRSGDEAKAYVTKLRTIMRYLGT CC2436 DQDP-------NATYVDLNRAGTALMEIVSKP----DMRTSEEAAAYVKKLRTILVYLGT RP151 DQSP-------YYSLIDLNRAGIGLMEIVTEP----DISSPEEAAEFVKKLRNLLRYIGS Rv3009c IGSETGRIHGATGSLIDYNRAGVPLIEIVTKPIVGAGARAPQIARSYVTALRDLLRALDV ML1700 LGSETGRIYGATTSLIDYNRAGVPLIEIVTKPIEGAGVRAPQIARAYVKALQDLLRTLDV DR2555 PTYAP-------YSLLDLNRAGSALIEMVTEA----DITGPEQARAFLESVQAIAQSLGV APE1718 EGSILT----SRYALVDYNRSGVPLLEIVTEP----DIPSPRHARMLIDYLLLTLEYIGA YBL080c TETDK-----DVITLVDLNRSNVPLIELVTKP----DFSDIKQVRAFIKKYQNLVRHLHI DR2611_2 ------------------------------------------------------------ AF2116 FDGDL-EGAMRVDANISIR------------GSG-----------RVEIKNISSFKGVEK VNG0345G FDAER-DGSLRVDANISMVDSAE------LAGEGGPSDDVLEAANRTEVKNISSHRAAQK MJ0160 LRG---EGTMRADVNISIEY----------MG-V--------QGNRVEVKNVNSIKGVYK MTH1280 ARG---EGTMRADVNISLE-----------------------GGKRVEIKNINSIKGAYK aq_461 SKADMEKGQLRCDINVSIRP----------KGSK-------EFGTRVEIKNVNSFRFVQK TM1273 STGDMEKGALRCDANISVVD----------TETG-------RQSNRVEVKNMNSFRFVER TP1021 TDGNLEEGALRCDANVNVRIL--------YKGQE-------HHTPISEIKNMNSYRMVRD BB0341 SECNMENGSFRCDVNVNLIVK--------ENGVE-------HKTPIAEIKNLNSFKSIKA MG100 SNAKLEDGSMRSDCNVSVRL----------KGQR-------QLGTKIEIKNINSLNNVEK MPN238 SNAKLEDGSMRSDCNVSVRL----------KGQT-------AFGTKVEIKNINSLNNVEK UU544 SDAKMEDGSLRVDVNVSIRP----------QGAK-------KFGTKVEIKNINSISNVAK CT004 SDCNMEEGSIRFDVNISVRPRG---------SRE--------LRNKVEIKNMNSFTFMAQ CPn0004 SDCNMEEGSIRFDVNVSVRPKG---------SPE--------LRNKVEIKNMNSFAFMAQ BS_yerN SDCKMEEGSLRCDANISLRPIG---------QEE--------FGTKTELKNLNSFAFVQK BH0667 SDCKMEEGSLRCDANISLRPVG---------QEE--------FGTKTELKNLNSFNFVRK L0474 SDVKMEEGSMRCDANVSLRPYG---------QEA--------FGVKTEVKNMNSFSNVKK SPy1770 SDVKMEEGSMRVDANISLRPYG---------QEQ--------FGTKTELKNLNSFSNVRK sll1435 SDGNMQEGSLRCDVNISVRPVG---------QKE--------FGTKVEIKNMNSFSAIQK NMB1358 CDGNMAEGSFRVDANVSVRPKG---------QEE--------FGTRREIKNLNSFRFLEQ NMA1570 CDGNMAEGSFRVDANVSVRPKG---------QAE--------FGTRREIKNLNSFRFLEQ PA4484 CDGNMAEGSLRCDCNVSVRPKG---------QAE--------FGTRAEIKNVNSFRFIEK jhp0603 SDANMQEGNFRCDANVSIRPKG---------DEK--------LYTRVEIKNLNSFRFIAK HP0658 SDANMQEGNFRCDANVSIRPKG---------DEK--------LYTRVEIKNLNSFRFIAK Cj1197c SDANMQEGSFRCDANVSIRPKG---------DTK--------LYTRVEIKNLNSFRFIQK mlr0190 CDGNMDEGSLRADVNVSVRRPG--------GEF----------GTRCEIKNMNSIRFIGQ CC2436 CDGDMEKGNLRADVNVSVCRPGDYEKFRATGDFKH-------LGTRCEIKNVNSYRYIQQ RP151 CDGDMEKGSMRCDANISVRRIG---------EA---------LGTRCEIKNINSIRNIIK Rv3009c SDVRMDQGSMRCDANVSLKPAG---------TTE--------FGTRTETKNVNSLKSVEV ML1700 SDVRMDQGSMRCDANVSLKPIG---------TVE--------FGTRSEIKNVNSLKSVEM DR2555 SDATPEEGKMRCDVNISIHKP----------GEP--------WGTKVEVKNLNSFRSVAR APE1718 TNPRL-EGVFRVDANISIE-------------G----------GERVEVKNIGSTQDVEK YBL080c SSGDLETGAMRVDVNLSIN-----------------------EYARVELKNLPNTSSIIN DR2611_2 ------------------------------------------------------------ AF2116 ALSYEIMRQKNL------LQRGRSVVRETRHFDEARNITVSLRSKEEEQDYRYFPEPDLV VNG0345G ALAYETTRQRNQ------LERGMAVAQETRHWDEARGVTVSMRSKEEEKDYRYFREADIP MJ0160 VLKYELIRQKNI------IKRGGEVKRETRAFLESQMITKAMRSKETAEDYRYIPDPDIQ MTH1280 ALKFEMIRQKNL------LKRGVEVKQETRAFLESQMITVSMRLKEEAEDYRYIPDPDLP aq_461 ALEYEIERQINV------VEEGGEVVQETRTFDPQTGKTYPMRTKEEAEDYRYFPDPDLV TM1273 ALEYEFERIVKA------MERGEDVERETRGWDMATKITVSMRGKEEESDYRYFPEPDIP TP1021 ACTYEVQRQLQEFWQKGPASKEEMQRKRTMGWDPVEGVTLLQRTKHSLRDYRFMRDPDLP BB0341 AIEYEELRQQQE-WIQFKKTLNSCG-KHTRGFDDRSGVTVIQRNKETVSDYRYFQEPDLP MG100 AIDLEINRQVKA------LINGETLSQATLSFDDKTNNNVFMRKKDNTIDYRYFIEPNIM MPN238 AIDLEIARQVKA------LIKGEPVQQVTLTYDDKTNTNVFMRKKDNSVDYRYFIEPNIM UU544 AIDYEIRRQLNL------ILLNQNVEQQTRRFDDNTNTTVFMRSKNDAINYRYIREANIA CT004 ALEAEKRRQIEEYLSYPNEDPKKVVPAATYRWDPEKKKTVLMRLKERAEDYMYFVEPDLP CPn0004 ALEAEKQRQIDEYLNQPNKDPKLVIPAATYRWDPEKKKTVLMRLKESAEDYKYFPEPDLP BS_yerN GLEHEEKRQEQVLLSG------GVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDLV BH0667 GLEYEEKRQAQVLLSG------GEILQETRRYDEAANKTVLMRVKEGSDDYRYFPEPDLV L0474 ALDFEVDRQAKILRAG------GEIRQETRRFNDKTGETILMRVKEGASDYRYFPEPDVP SPy1770 GLEFEVERQAKLLRSG------GVIRQETRRYDEANKGTILMRVKEGAADYRYFPEPDLP sll1435 AIEYEIERQIKAIADG------EEIYQETRLWEEGSQRTISMRKKEGSSDYRYFPEPDLP NMB1358 AINYEAEAQIEILEDG------GKVQQATMLFDPEKGETRVMRLKEDAHDYRYFPDPDLL NMA1570 AINYEAEAQIEILEDG------GKVQQATMLFDPEKGETRVMRLKEDAHDYRYFPDPDLL PA4484 AINHEIQRQIELIEDG------GKVVQETRLYDPNKDETRSMRGKEEANDYRYFPCPDLL jhp0603 AIEYEIERQSVAWENGRYN---EEVVQETRLFDTAKGITLSMRNKEESADYRYFKDPDLY HP0658 AIEYEIERQSAAWENGRYN---EEVVQETRLFDTHKGITLSMRNKEESADYRYFKDPDLY Cj1197c AIEYEVKRQSEAWEDGTYE---QEVVQETRLFDTTNLVTRSMRGKEEAAEYRYFPDPDLL mlr0190 AIDYEARRQIAILEDG------GKIDQETRLYDAVKGETRSMRSKEEAHDYRYFPDPDLL CC2436 AIEYEARRQIEILEDG------GKVDQETRLFDPTKGETRSMRSKEEAHDYRYFPDPDLL RP151 AIEFEAKRQVDLLESG------ETIIQETRLFNVDSCETKTMRLKEEALDYRYFPDPDLL Rv3009c AVRYEMQRQGAILASG------GRITQETRHFHEA-GYTSAGRTKETAEDYRYFPEPDLE ML1700 AVRYEMQRQGAILVSG------GRIAQETRHFHED-GYTSPGRAKETAQDYRYFPDPDLE DR2555 AIEYEAARQAKVLDAG------GIITQDTLGWDEGGQKTFLMRTKEGEADYRYFPEPDLP APE1718 ALKFEISRQRLIVERG------GKVERETRHWDAERGMTKPLRLKEEEADYLYFPDPDLP YBL080c AIKYEYQRQVELISVG---DTSSLMEPETRGWTGS--STVKLRSKETTIDYRYMPDPELP DR2611_2 ------------------------------------------------------------ AF2116 PVLT-EEIVREVE--GTLPEMPEEKRERLKR-QYGIGDNFAKVLILDVK----------- VNG0345G PLEV-SDWKDEIP----IPELPDARRERFRT-EYGVGDETASKLTSRKA----------- MJ0160 PIVISEKWVKEIE--EKMPETPLAKKKRFVE-EYGIDEEDAKVLVSDLD----------- MTH1280 PMKFTDEVVEGLR--ERIPEAPHLKVKRFME-EYGLREEDARVLTSELE----------- aq_461 PLKVKKEWIEEIK--KNMPELPDQRFERLIK-EYGLSEYEAGILVNHKE----------- TM1273 PVVLSDEYLEEVK--KELPELPDEKAERFMR-EYGLPEYDAKVLTSSKE----------- TP1021 DLHLTPAYVQHLS-Y-TVGELPAARRARFKL-DLGLSAFAAQTLTGSRM----------- BB0341 LIEIDDSYIDNIKNL-KLIELPFHARIRLKG-QYGLSDFDVITLTADKH----------- MG100 TSNIDDLLLEK---P-VAFQLEQF-QKELI--DSNVNPQLVQLVVDDAT----------- MPN238 SSNIDELLQKP---N-KAFNLTEF-FTKLK--EAGVNEQLNQLVVDDLT----------- UU544 PIHLSDDYVKKMFLT-KSCSINDL-RQQLA--QKGLVSSAIEQLLSDGP----------- CT004 VLQITETYIDEVR--QTLPELPHSKYMRYIT-DFDIAEDLAMILVGDRH----------- CPn0004 TLQLTESYIERIR--KTLPELPYDKYHRYIQ-EYGLSEDIASILISDKN----------- BS_yerN ELYIDDEWKERVK--ASIPELPDERRKRYIE-ELGLPAYDAMVLTLTKE----------- BH0667 ALHIDDEWKARIR--SEIPELPDARKKRYVE-ELGLPAYDAMVLTLTKE----------- L0474 RFEISEEWVEQMR--ESLPMTAKARRAHYIN-DLALSDYDARQLTATKE----------- SPy1770 LYEIDDAWIDEMR--AQLPQFPAQRRAKYEE-ELGLSAYDASQLTATKV----------- sll1435 PLEVSEQQKQTWF--ATLPELPSAKRARYEQ-KLGLSAYDARVLTEDRD----------- NMB1358 PVIISDAQMQKAK--AEMPELPKEMAARFVA-DYGVSEYDARLLTASRA----------- NMA1570 PVIISDDRLQKAK--AEMPELPKEMAARFVA-DYGVSDYDARLLTASRV----------- PA4484 PVVIEPEYLAKLR--EQLPELPVQKRERFES-QYGLSAYDASVLSASRE----------- jhp0603 PVFIDEKLLKEA---QKINELPGAKKIRYMK-DFNLKEDDANLLVSDPL----------- HP0658 PVFIDEKLLKEA---QKINELPSAKKIRYMK-DFNLKEDDANLLVSDPL----------- Cj1197c PVLLKDEFLD-----IKIPELPDEKKVRFID-KLGIKESDAEVLISSLE----------- mlr0190 PLEFDQAYVDALA--KELPELPDDKKARLIT-SLGLSTYDASILVSEKS----------- CC2436 PLVLDPAWVKSIE--ETLPELPDAKKARLQS-QYGLSAYDAGVLIIDAD----------- RP151 PLIIPDELINELK--ASLPELPDQKIEKYIK-KFGLSQYDAGIIVSDEA----------- Rv3009c PVAPSRELVERLR--QTIPELPWLSRRRIQQ-EWGVSDEVMRDLVNAGA----------- ML1700 PVAPSRELVEQLR--QTIPELPWLSRKRIQQ-EWGISDEVMRDLVNAGA----------- DR2555 PLDITPEWIAEVR--ARMPELPAQKLERYR--AAGVRESDAQTLSLSVS----------- APE1718 PVEITEDMLAEAE--KLASKTPGT-IYREIE-SMGVRREIAWSITSTLP----------- YBL080c YINLAPDVISGVR--GLMPQLPDDIMRILMKKPYQLSLKDAKILTYNSNQNDMYNHEALR DR2611_2 ------------------PLTPEQDAEFTRLLGLGASEGDARTIARDPA----------- : AF2116 --MADYFEEVAKLVDP------KLAASWIVDVLRGELNYRDWSFAKCWEVFKPEEFAKLL VNG0345G --VADLFEELADEYDA------ALAATWVADNVLGELNYRDLSLDDVAD--RDDEFERLV MJ0160 --MAEMFEEVVKSLGVN-KENVDLAVTWIRNELRRSLQYHKVDLYESGV--KAEHIVELI MTH1280 --LADAFEEVAGSIDP------EFAALWMRDELKRVLYYNKISFAESMI--TPGDIIELL aq_461 --VGDFFEEAVRHFKE--P---KGIVNWLINDLLGLLRDKGISIEESPV--KPEHLAELV TM1273 --LAEFFEECVKVVNR--P---KDLSNWIMTEVLRELNERNIEITESKL--TPQHFADLF TP1021 --LADWFEKAAHASKN-----ARRVANWILSEVLAVVNEKNIC--IAELNLSPEAIAELM BB0341 --LLKYFEEAVINSSD-----PKKVANWILSEVLSVLNDKGIS--VLEFNLLPSYITELV MG100 --IFSAFQTINSVIKN-----PQETIRWLCIELIGQLNKTNS---SLTANLIQD-LITLI MPN238 --LFNAYTKINSVINS-----PQDTIRWLCIELMGQLNKLQK---PLKDKTIDH-LIILI UU544 --LFKAFKYVDKIVNN-----PLSVYKWLCLEFIGLINKNTQNIEEITPELLQK-IARMI CT004 --TAHFFETATMSCKN-----YRALSNWITVEFAGRCKARGKTLPFTGIL--PEWVAQLV CPn0004 --IATFFEVACKDCKN-----FRSLSNWVTVEFGGRCKTLGVKLPSSGIF--PEGVAQLV BS_yerN --MADFFEETVQKGAE-----AKQASNWLMGEVSAYLNAEQKELADVALT--PEGLAGMI BH0667 --MSDFFEETIAKGAD-----PKLASNWLMGEVSGYLNAEQKELDEVALT--PDGLAKMI L0474 --VSDFFDQAIKFDTD-----PKLVSNWLQGEVAQYLNSEKKELHEIGLT--PENLTEMI SPy1770 --LSDFFETAVSLGGD-----AKQVSNWLQGEVAQFLNAEGKTIEEIALT--PENLVEMI sll1435 --VALYFEEAVNAGAD-----PKAVANWVTQDIAAYLNNNRLTISGLALK--PSALAELI NMB1358 --QAAYFEEAAKESGQ-----GKLTANWMNGELAAALNKEGMELADSPIT--APRLAALV NMA1570 --QAAYFEEAAKESGQ-----GKLTANWMNGELAATLNKEGMELADSPIT--APRLAALV PA4484 --MADYFEKVQGICGD-----AKLAANWVMVELGSLLNKDGLEIEQSPVS--AEQLGGMI jhp0603 --LAEYFESMLNLGVK-----AKTSVTWLCVELLGRLKAE-VTLENCGIS--AHALGALA HP0658 --LAQYFESMLHLGVK-----AKTSVTWLCVELLGRLKAE-ITLENCGVS--THMLGALA Cj1197c --MSRFFESLISQNLN-----PKLCVNWLNTELMGLLKGE-LTIENSPVD--AQKLGVLI mlr0190 --VADYFEKVAA-GRD-----GKLAANWVINDLLGQLNKVGKDIENAPVS--PDQLGAII CC2436 --RADYFEAAAK-GRD-----AKLVANWVTNELLAKLSAAGTEFTNSPLP--HTDIAQLV RP151 --VAEYFEKAAN-ECN-----PKMLTNWLITELFGQLNKASIGIRECKIT--PSDFAKLI Rv3009c --VELVAATVEHGASS------EAARAWWGNFLAQKANEAGIGLDELAIT--PAQVAAVV ML1700 --VELVAATVKNGASS------EQARAWWGNFLVQKANEANITLDELAIT--PAQVAVVV DR2555 --LSKFYDEALKSGSDTQKPDAQKLANWLLTDVAGALAAQEKGVEDSDLQ--PAHLAALV APE1718 --AARLFLEAVKLGAD-----PRIAARLVGVDLKGELKEMGKDLYSPNNWPPPQSIAILS YBL080c SYYLDTFREFSKLAGE--RSNAKLPTNWIIHEFLGDLNKLQIPLAKAKEILAPPVFAQFL DR2611_2 --L-LAFVGGAAPGDT-----FAQVASWTVNELVAGLRAG-----EVKVR--AADLAPLA . . . AF2116 KYFEEDRITEKGVVEVI-RTKLDE-G--------GEIDAIIQKKGLFAIP--KE-EIIKF VNG0345G ELVAEDEITAKNAEEVVLRTMLDE-D--------RAPDEIVDAEGLGKTS--GD-AVADA MJ0160 KLIKEGVISQKIAKEIVDLLVINRGK--------KMPKELVEELGLTVIR--DEDALVKA MTH1280 AMIRKKEITSKAAKKIIEEMPLN--K--------KGPREIATEMGLIGII--DESEVIRA aq_461 KLIKEKVISTKIGKEVIKEMVET--G--------KTPSQIVEEKGLKQIT--DENQIKEL TM1273 KLMDEGKISIKIAKEIFPEVFET--G--------KMPSQIVEEKGLTQIN--DEKLIEEL TP1021 DAVEDQRITGKQAKDIFAQMLAT--G--------ARAQDIISAQGLAQLS--DEEEIATL BB0341 EFIVAGKISGKMAKRVFSEMMTR--G--------VSASVVISENQLEQVS--DKFVIKQI MG100 EMLKAAKVNQKQAKQLITLMIET--K--------KDPKSLAKLHNLEQIT--DPKELQKI MPN238 QMVQKGTVNQKQAKQLIELMLDN--G--------QDPQSLAKLHNLEQIT--DEKQLTQI UU544 LLFDQTLINGKQTKIILEKIYLT--N--------KDPQILIKELGFEQIT--NENEITKL CT004 NFIDRGVITGKIAKEIADRMVSSFGE--------SPEDILRRHPSLLPMT--DDHALRAI CPn0004 NAIDQGVITGKIAKEIADLMMESPGK--------NPEEILKEKPELLPMS--DEGELQKI BS_yerN KLIEKGTISSKIAKKVFKEL-IEKGG--------DAEKIVKEK-GLVQIS--DEGVLLKL BH0667 QLIEKGTISSKIAKKVFKDL-IEKGG--------DPEEIVKAK-GLVQIS--DEGELRKY L0474 RLISDGTISSKIAKKVFIEL-AKNGG--------SAEEFVKKA-GLVQIS--DPAVLLPI SPy1770 AIIADGTISSKMAKKVFVHL-AKNGG--------SARAYVEKA-GLVQIS--DPAVLVPI sll1435 DLITKGTISGKIAKDILPEL-LEKGG--------SPQKIIEAR-GLVQIS--DPDELTAI NMB1358 GKIADGTLSSKLAKKAFEAMWAEPEA--------TIAEIIEKH-GLQQMT--DTGEIEAM NMA1570 GKIADGTLSSKLAKKAFEAMWAEPEA--------SIAEIIEKH-GLQQMT--DTGAIEAM PA4484 LRIKDNTISGKLAKMVFEAM-ANGEG--------SADQIIEAK-GLKQVT--DSGAIEKM jhp0603 KRIDEGKISGKSAKDVLDRLLEEQGG--------DVDTLIEQM-GLSQVN--DTEAIVKV HP0658 KRIDEGKISGKSAKDVLDKLLEEQGG--------DVDALIEQM-GLSQVN--DTEAIVKV Cj1197c KRIEDGTISAKAAKDVLAFVFENTSV--------EIDEAIEKL-GLKQVS--DDSAIEAV mlr0190 DLIKDGTISGKIAKDLFEIV-WSEGG--------DPRALVESR-GMKQVT--DTGAIEKA CC2436 ELIENGTISSKIAKEVFEHM-WAGEG--------RPAEIVEKR-GLVQIN--DTGAIEKA RP151 KLIEHDTISGKIAKTVFEIM-FETGK--------APDKIVEEK-RLVQIS--DNKILNTV Rv3009c ALVDEGKLSNSLARQVVEGVLAGE-G--------EPEQVMTAR-GLALVR--DDSLTQAA ML1700 ALVDEGKLSIRLARQVVEGVLAGE-G--------EPEQVMVDR-DLALVR--DDSVMQAA DR2555 GLIDAGTISGKIAKDLLPDVLAG--H--------DPAQLVQER-GLSVVT--DTGAIDAA APE1718 NLVARGDYTYDSIKGLVVPKLAA-----------NPGSDVKSL--LPEKV--KD--IERL YBL080c KLLHEEVISATSGKMLLFHILENFEQSNCQDLSIPDFSKLIEKFELHAINQVDPQELMDL DR2611_2 EGVASGQLSARIAREALARAAASG----------DAPLTIIEREGLNAGL--SAEALQQV . . : : AF2116 CKEAIEENPK--AVEDYLSGKR----QALNFLVGQVMKKTRGRA-DPADTAKLIEEMLS- VNG0345G VAEAIAENPD--AVADYHDGEG----DALNFLVGQVMAKTGGSA-DPGQVNELLRDELAQ MJ0160 VEEAIKNNPK--AVEDYLNGKK----EALNFLMGQVMRLTRGRA-DPKRVIELLKERLDK MTH1280 VEQAIRENPG--AVEDYHAGKE----AAINFLVGQVMRMTRGKA-EPERTVELIKERI-- aq_461 VKKIFEKHPK--EVERLKQGEE----KLIGFFVGQVMRETRGKA-NPQVVNKVIRELVKE TM1273 VKKAMEQNPK--AVQDYKSGKK----KAAGFFVGYVMRETKGKA-NPELTNRIIQKLLEG TP1021 VQTVFQEHPK--ALRDWQHGKT----NVAAWLMGQVMKRSRGRA-HPARVATLVHQALSQ BB0341 VLEVLDENPK--SIELYKKGKD----HAIKFMMGQIMKKSSGKI-NPILANEILLESLSN MG100 IKKIFQENEK--EILKNIDRIE----RIQKLIIGQVMHKTNNRA-NPQQVFIIVENMLHE MPN238 IQQIFKENEG--EILKNLDRVE----RIQKLIIGQVMQRTHNRA-NPQQVFIIVEKLLHD UU544 WHQILAKNQE--MLLQYNERPD----RVEKFFMGEIMKLTKAQA-NPTISFNVLKKILQK CT004 VKEVVAQNTA--SVADYKNGKA----KALGFLVGQIMKRTEGKA-PPKRVNELLLAAMRD CPn0004 IAEVVLANPE--SIVDYKNGKT----KALGFLVGQIMKRTAGKA-PPKRVNELLLLELDK BS_yerN VTEALDNNPQ--SIEDFKNGKD----RAIGFLVGQIMKASKGQA-NPPMVNKILLEEIKK BH0667 VVEVLDNNQQ--SIDDFKNGKD----RAIGFLVGQIMKATKGKA-NPPMVNKLLLEEINK L0474 IHDVFAKNEQ--SVADYRGGKQ----NAAKALVGQLMKATKGQA-NPTVAQKLLYQELDN SPy1770 IHQVFADNEA--AVADFKSGKR----NADKAFTGFLMKATKGQA-NPQVAQQLLAQELQK sll1435 IQAVIADHPK--ELEKFRSGKG----NMQGFFVGQVMKRTGGKA-DPKLTNQLIGKLLAQ NMB1358 VDEVLANNAK--AVEQFKSGNE----KALNAIVGQVMKASKGKA-NPAQVQELIKAKLA- NMA1570 VDEVLANNAK--AVEQFKSGNE----KALNAIVGQVMKASKGKA-NPAQVQELIKAKLA- PA4484 LDEVLAANAE--QVEQYRAADEAKRGKMFGFFVGQAMKASKGKA-NPQQVNELLKKKLEA jhp0603 IEEVLKNNAD--KVLEYKSGKD----KLFGFFVGQAMKNLKGA--NPSVVNAILKEKLD- HP0658 IEEVLKNNAD--KVLEYKSGKD----KLFGFFVGQAMKNLKGA--NPSVVNAILKEKLG- Cj1197c IEQILNANAD--KVAEYKSGKD----KLFGFFVGQTMKEGKGAF-NPAKVNEILKTKLG- mlr0190 VDEVIAANPD--KVEQARA-KP----TMAGWFVGQVMKATGGKA-NPQAVNDLVKAKLGI CC2436 IDDLIAGNPD--KAEAVKD-KP----QALGWFVGQVMKATGGKA-NPGTVNELLRKKLGV RP151 IDEVIAENSK--SVKCYKSGKD----KLFGFFVGQVMKKTECKA-NPTLVNKLLKDKLDS Rv3009c VDEALAANPD--VADKIRGGKV----AAAGAIVGAVMKATRGQA-DAARVRELVLEACGQ ML1700 VDEALAADPD--VAEKIRGGKV----AAAGAIVGAVMKTTRGQA-DAARVRELVLAICGQ DR2555 IDAAMEADPA--TVEKVRGGNA----KAMNALFGPVMKAMGGKA-KPEVVRERLTAKLGL APE1718 VEEVLNREKR--AVQDYLAGKK----KALNYLVGQVMRAAKGRALDPRQAREILLRRLST YBL080c CNDVIAQHTDDTFIRNLVTGKKK---SSLKFLIGQGMRRSQGRI-KANEFEKKFKEILNI DR2611_2 VAQVIAANPD--KAEAYRGGKT----ALLGFFTGQVMRATAGKA-DPQALAAALKDALA- . . : * * . . AF2116 ------ VNG0345G A----- MJ0160 ------ MTH1280 ------ aq_461 V----- TM1273 E----- TP1021 L----- BB0341 V----- MG100 VRERDS MPN238 FSERAS UU544 ------ CT004 M----- CPn0004 G----- BS_yerN R----- BH0667 R----- L0474 F----- SPy1770 LRD--- sll1435 A----- NMB1358 ------ NMA1570 ------ PA4484 ------ jhp0603 ------ HP0658 ------ Cj1197c ------ mlr0190 E----- CC2436 E----- RP151 ------ Rv3009c G----- ML1700 G----- DR2555 ------ APE1718 VKEEDR YBL080c QW---- DR2611_2 ------