CLUSTAL W (1.74) multiple sequence alignment mlr8250 -----MPTGYADGRSMTDTVETIDYSKTLYLPQTDFPMRAGLP----EKEPVLVKRWQDM CC0701 ---------MAD-----DATTARDYRETVFLPDTPFPMRAGLP----KKEPEILEGWAAL ileS ---------------------MSDYKSTLNLPETGFPMRGDLA----KREPGMLARWTDD ZileS ---------------------MSDYKSTLNLPETGFPMRGDLA----KREPGMLARWTDD VC0682 ---------------------MSEYKDTLNLPETGFPMRGDLA----KREPEMLQRWYQE HI0962 --------------------MTVDYKNTLNLPETSFPMRGDLA----KREPDKXKNWYEK PM1662 --------------------MTVDYKNTLNLPETGFPMRGDLA----KREPNMLKSWYEK PA4560 ---------------------MTDYKATLNLPETAFPMKAGLP----QREPETLKFWNDI NMB1833 ---------------------MTDYSKTVNLLESPFPMRGNLA----KREPAWLKSWYEQ NMA0622 ---------------------MTDYSKTVNLLESPFPMRGNLA----KREPAWLKSWYEQ XF2418 --------------------MSQDYKTTLHLPATDFPMRGDLP----KREPAILERWERD BU149 ---------------------MDDYKDTLNLPKTLFSMRGNLS----KKEPNILKSWNEN BS_ileS ----------------------MDFKDTLLMPKTDFPMRGNLP----NREPDIQKKWEEE BH2545 ----------------------MDFKETLLMPKTDFPMRGNLP----NREPQMQEEWKDM L0350 ----------------------MKIKDTLNLGKTAFPMRAGLP----NKEPNWQKDWADA SPy1513 ----------------------MKLKETLNLGKTAFPMRAGLP----NKEPQWQAAWEQA sll1362 ------------------MTEAKSYKDTVNLPQTRFDMRANAN----KREPEIQQYWQEK aq_305 -----------------MEEKKVDLKDTLNLPRTEFPMKANLP----QREPQILEKWK-- TM1361 ----------------------MEYKNTLNLPKTSFPMKANLV----NKEKVFLEEWEKM jhp1317 ---------------------MKEYKDTLNLNETTFSMKGNLS----VNEPKTYAKWQEQ HP1422 ---------------------MEEYKDTLNLNTTTFSMKGNLS----VNEPKTYAKWQEQ Cj1061c ----------------------MDYKETLLLPSTTFAMRANLA----ELEPQRFKKWFEQ MG345 ----------------------MDLKKTLLMPKTSFAMQANLS----TSEKNFHDFWKDK MPN520 ----------------------MNLKKTLLMPQTAFEMQGKLT----TKEQQFQAFWQSK UU410 ---------------------MKDYKSTLNMPTTGFEMRANLN----VKEPKIQQFWVEH PH1065 --------------------MIKEPEFR----------DYTPG----KLEEKIEEFWKEN PAB0616 --------------------MIKEPEFR----------EYDPK----KLEEKVEKFWSEN MTH1375 --------------------MPIQEAEK----------SYRPH----RIEEKVQSFWEER MJ0947 ---------------------MKKVEPV----------NFR------ELDKKIKKFWEEN AF0633 ------------------------MLPA----------KYSPK----DVESEIFKFWEDN APE0374 -----------------MGSVPRVLEGE----------RYDQF----ALESFVKSYWEEN Ta0879 ---------------------------------------MTLR----EIDSEILKYWKDK TVN0829 --------------------MQAQRYRL-------IEQGNTIM----DIDNEILRYWNDH CT019 ----------------------MDNEDK-----------ISIS----AKEEKILSFWKEQ CPn0109 --------------------MTADEVGK-----------NSFA----KKEEQVLKFWKDN TP0452 --------------------MYTPVDPK-----------VDFV----AQERRILAFWRER BB0833 --------------------MFKKVENK-----------ANFP----KIEEKILKFWNDN Rv1536 --------------------MTDNAYPK------LAGGAPDLP----ALELEVLDYWSRD ML1195 --------------------MTNSAYPRTDLGADQRGGSPNFP----ALEAQVLDYWSND RP617 --------------------MTNTKYYP------DVSANVDFA----AIEQEILKFWQNN YBL076c ----------------------MSESNA----------HFSFP----KEEEKVLSLWDEI VNG2190G ---------------------MSGFGDV--------PDQYDPA----GVEERVFSYWEAV DR1335 --------------------MTKRTFAP-------VPTQPNFR----QLEADILQKWKDE YPL040c MKRSRLVPQHIFSIISKRYLAKHAYQKTLNLPKTKFPNRSNLEITLRELIPKSSQLVYKE mlr8250 D---LYAKLRES---AAG-----RTKYVLHDGPPYANG-NIHIGHALNKILKDVITRSFQ CC0701 SEKGLYGAVRQKR-QAAG-----APLFVFHDGPPYANG-AIHIGHALNKILKDFVVRSRF ileS D---LYGIIRAA---KKG-----KKTFILHDGPPYANG-SIHIGHSVNKILKDIIVKSKG ZileS D---LYGIIRAA---KKG-----KKTFILHDGPPYANG-SIHIGHSVNKILKDIIVKSKG VC0682 D---LYGAIRQA---KKG-----KKSFVLHDGPPYANG-DIHIGHALNKILKDVIIKSKT HI0962 N---LYQKIRKA---SKG-----KKSFILHDGPPYANG-NIHIGHAVNKILKDIIIKSKT PM1662 D---LYQKIRQA---SKG-----KKSFILHDGPPYANG-TIHIGHAVNKILKDIIVKSKT PA4560 G---LYQKLRAI---GGD-----RPKFVLHDGPPYANG-SIHIGHAVNKILKDIIVRSKT NMB1833 K---RYQKLREI---AKG-----RPKFILHDGPPYANG-DIHIGHAVNKILKDIIIRSKT NMA0622 K---RYQKLREI---AKG-----RPKFILHDGPPYANG-DIHIGHAVNKILKDIIIRSKT XF2418 D---FYAQLRAH---AKG-----RPLFLLHDGPPYANG-QIHLGHAVNKILKDIIIKSKH BU149 N---LYKLIRKK---NQE-----KKIFFLHDGPPYANG-NIHIGHAVNKILKDIIIKSKN BS_ileS D---IYRLVQER---TKD-----RPKFVLHDGPPYANG-DIHMGHALNKILKDFIVRYKS BH2545 N---IYEKVQAR---TKG-----RPLFVLHDGPPYANG-DIHMGHALNKVLKDMIVRYKS L0350 T---LYEKRQEL---NEG-----KPSFMLHDGPPYANG-NIHLGHSLNKISKDIIVRYKS SPy1513 E---LYKKRQEL---NAG-----KPAFHLHDGPPYANG-NIHVGHALNKISKDIIVRSKS sll1362 G---IYADLADN---NP------KDLFVLHDGPPYANG-ALHMGHALNKVLKDIINKYKL aq_305 G---LYEKIQKE---RKG-----REVFVLHDGPPYANG-HIHVGHALNKILKDVINKYNL TM1361 D---LYNYVLEQ---RKG-----KPLFVLHDGPPYANG-HIHIGTALNKILKDIVVKYKT jhp1317 ---QAFKRMQ-NR--KDN-----HGDFTLHDGPPYANG-HLHLGHALNKILKDIVIKREY HP1422 ---QAFKRMQ-AR--KDN-----HGDFTLHDGPPYANG-HLHLGHALNKILKDIVVKREY Cj1061c N--YAYEKMKENR--KNA-----KKSFTLHDGPPYANG-HIHIGHALNKILKETIIKTHY MG345 K---VFQKLKKQ---NKG-----KQIKILHDGPPYANG-SIHVGHALNKILKDFILRSWL MPN520 R---IYQKLHRQ---NKD-----KPQKILHDGPPYANG-NIHVGHALNKILKDFVLRSWN UU410 Q---IYEKLLTK---NKD-----KKPFILHDGPPYANG-NIHIGHALNKILKDFVVSYHN PH1065 N---IYQKIKELR---KN-----GPKYYFLDGPPYVSG-AIHLGTAWNKIIKDMIIRFRT PAB0616 E---IYRKVKELR---KD-----GPKYYFLDGPPYVSG-AIHLGTAWNKIIKDMIIRFRT MTH1375 D---IYERVKELR---ED-----RPRYSFLDGPPYCSG-RIHLGTAWNKIMKDTYLRFKS MJ0947 D---IYQKVKKKN---ER-----NKEFYFVDGPPYCSG-AIHLGTAWNKIIKDTYLRFKR AF0633 D---IYRKVKE-----KG-----GRKFYFVDGPPYTTG-RIHLGTAWNKVLKDTILRYKR APE0374 S---IYRKVKEKSS--RA-----PRKFYFLDGPPYASAKSIHIGTAWNKVVKDVVLRFYR Ta0879 N---ILEK-ILSK---GG-----SKKFVFLEGPPTANG-RPHIGHAMTRTIKDIVLRYNT TVN0829 A---INEK-IFKK---EG-----TKKFVFLEGPPTANG-RPHIGHAMTRTIKDIVLRYNT CT019 D---IFQKTLDNR---EG-----CPTFSFYDGPPFATG-LPHYGHLLAGTIKDVVCRYAS CPn0109 Q---IFEKSLQNR---QG-----KTLYSFYDGPPFATG-LPHYGHLLASTIKDVVGRYAT TP0452 R---VFEQSVAQR---AQ-----GKSYVFFDGPPFATG-LPHFGHFVPSTIKDIIPRYQT BB0833 K---IFEKSIKQR---EG-----CEEFTFYDGPPFATG-LPHFGHFVPNTIKDIIPRYQT Rv1536 D---TFRASIARR---DG-----APEYVFYDGPPFANG-LPHYGHLLTGYVKDIVPRYRT ML1195 D---TFRASIARC---DD-----APEYVFYDGPPFANG-LPHYGHLLTGYVKDIVPRYRT RP617 N---IFQKSIDYR---NG-----ESEFIFYDGPPFANG-LPHYGHLLTGFIKDVYARYKT YBL076c D---AFHTSLELT---KD-----KPEFSFFDGPPFATG-TPHYGHILASTIKDIVPRYAT VNG2190G D---AYEQTVDHR---AD-----AETFFFVDGPPYTSG-AAHMGTTWNKTLKDAYIRYHR DR1335 Q---VFEQTQTRP---AP-----AGEFVFYEGPPTANG-KPALHHVLARSFKDLFPRFKV YPL040c QLRDFFEEFSKLNTTDEKLEFIKEKLFILHDGPPYANG-ELHLGHALNKILKDIINRYQL : :*** .. *: mlr8250 MRGYDSTYVPG-WDCHGLPIEWKIEEQYRAKGKNKDEVPV----NEFRKECREFAAHWIT CC0701 ALGYDVDYVPG-WDCHGLPIEWKIEEQFRAKGRRKDEVPA----EEFRRECRAYAGGWIE ileS LSGYDSPYVPG-WDCHGLPIELKVEQEYGKPG---EKFTA----AEFRAKCREYAATQVD ZileS LSGYDSPYVPG-WDCHGLPIELKVEQEYGKPD---EKFTA----AEFRAKCREYAATQVD VC0682 LSGFDAPYIPG-WDCHGLPIELMVEKKVGKPG---QKVTA----AEFREKCREYAAGQVE HI0962 ALGFDSPYIPG-WDCHGLPIELKVEGLVGKPN---EKISA----AEFRQKCREYAAEQVE PM1662 ALGYDSPYIPG-WDCHGLPIELKVEGLVGKPN---QNISA----AQFREACRQYAAEQVE PA4560 LAGYDAPYVPG-WDCHGLPIEHKVETTHGK------NLPA----DKTRELCREYAAEQIE NMB1833 QAGFDAPYVPG-WDCHGLPIEVMVEKLHGK------DMPK----ARFRELCREYAAEQIA NMA0622 QAGFDAPYVPG-WDCHGLPIEVMVEKLHGK------DMPK----ARFRELCREYAAEQIA XF2418 LDGFDAPYIPG-WDCHGLPIEIAIEKKYGKVG---VTLDA----VQFRQKCREYAAEQIQ BU149 MSGFDAPYIPS-WDCHGLPIEQKVEEKIKSNQ---GEIST----TEFQEKCRKYAQDQVE BS_ileS MSGYNAPYVPG-WDTHGLPIETALTKNKK---VNRKEMSV----AEFRKLCEEYAWKQIE BH2545 MAGFHAPYVPG-WDTHGLPIEQALTKSG----VDRKSMSV----AEFRKLCEEFARKQID L0350 MAGFRAPYVPG-WDTHGLPIEQQLAKAG----MKRKEMDL----LDYLEECRKYAMKQVD SPy1513 MSGFQAPYVPG-WDTHGLPIEQVLAKQG----IKRKEMDL----AEYLEMCRQYALSQVD sll1362 LQGHKVHYVPG-WDCHGLPIELKVLQSLK--SSERAELTP----LTLRHKARDFALKAQQ aq_305 LIGKNVNFIPG-WDCHGLPIERAVEKELSKKKIKKESLPK----TEFRELCREYAKKYVN TM1361 MRGYRAPYVPG-WDTHGLPIEHRVSQELG-EKIKEMSP------AEIRKKCEEFALRFVD jhp1317 FKGKKIYYTPG-WDCHGLPIEQQILEQLEK---EKTSLEN---PTLFREKCRDHAKKFLE HP1422 FKGKKIYYTPG-WDCHGLPIEQQILERLEK---EKTSLEN---PTLFREKCRDHAKKFLE Cj1061c FKGESVRFTPG-WDCHGLPIEQQVEVKLGE---KKKSLSK----KEIREFCRQHASEFVD MG345 YEGYDVVFIPG-WDCHGLPIEHAVSKKNP----SSYSNLS---TVEKRKLCHQFALSQIA MPN520 LQGFGTVFIPG-WDCHGLPIEHAVSKKDP----QHYASLS---LSEKRDLCKQFALSQIA UU410 MNNYYSPYIPG-WDTHGLPIEVALSKK------IKLSNLS---VNERREQCKKYALEQVN PH1065 MQGYNVWRQPG-FDMHGLPIEVKVEQALGLK--TKKEIEEKIGVENFIKKCKEFALNNLK PAB0616 MQGYNVWRQPG-YDMHGLPIEVKVEQALGLK--TKKEIEEKIGVENFIKKCKEFALNNLK MTH1375 MKGFNVRRQPG-WDTHGLPIEHKVEGLLGVR--SKKDIEDKIGIEEFVNKCREFAVENKA MJ0947 MQGYNVLDKAG-WDMHGLPIEVKVENEFGIK--NKKEIETKIGVKQFIEKCKEFALKHKE AF0633 MMGFAPTDTPG-WDMHGLPIEVKVEQELGFR--TKRDIES-FGIDKFIERCMNYALANKD APE0374 MTGYNVWDKPG-YDTHGLPIEVKIEQSLGVR--VKREIEEKVGVENFIAACKRFVDENME Ta0879 MTDHKIYRRVGGWDCHGLPVELEAEKHFGFH--TKSEIVN-FGVEKFNQYCRESIFRYID TVN0829 MTGHKIYRRYGGWDCHGLPVELEAEKYFGFK--TKSDIIN-YGVEKFNSYCRDSVFRYID CT019 MDGHYVPRRFG-WDCHGVPVEYEVEKSLGLT--EPGAIER-FGVANFNEECRKIVFRYAD CPn0109 MDGYYVPRRFG-WDCHGVPVEYEVEKSLSLT--APGAIED-FGIASFNEECRKIVFRYVH TP0452 MRGAYVPRRFG-WDCHGLPIEHLIEQELNLN--SKSDVES-YGVSAFNAACRSSVLRYVK BB0833 MQGKYVKRNFG-WDTHGLPVEYEVEKKLGIS--GKYEIEN-YGIENFNKECRKIVLRYTE Rv1536 MRGYKVERRFG-WDTHGLPAELEVERQLGIT--DKSQIEA-MGIAAFNDACRASVLRYTD ML1195 MCGYKVERRFG-WDTHGLPAELEVERQLGIT--DKSQIDA-MGIAAFNEACRKSVLRYTE RP617 IKGKKVERRFG-WDCHGLPAEMQSEKELGIS--GRIAITN-FGIEKFNNHCRASVMQYAS YBL076c MTGHHVERRFG-WDTHGVPIEHIIDKKLGIT--GKDDVFK-YGLENYNNECRSIVMTYAS VNG2190G MQGYDVTDRPG-YDMHGLPIETKVEEQLGFE--SKKDIQEFG-EEAFIEECKRFADDNLD DR1335 MQGHHVTRKGG-WDTHGLPVEISVEKKLGWLGRNHGASRE--ELEEFNRLCRTSVWETIQ YPL040c SQGKYIFYKPG-WDCHGLPIEIKALKDLSAQ--QIESISP----LKIRSMALKHAQKAIK . . :* **:* * . mlr8250 VQGGEFQRLGVIGDFKNPYTTMAFHAESRIAGELLKFALSGQLYRGSKPVMWSVVERTAL CC0701 AQKTEFQRLGVLGDWWNRYATMDFTSEAKIVEEFHKFLATGQLYRGSKPVMWSPVERTAL ileS GQRKDFIRLGVLGDWSHPYLTMDFKTEANIIRALGKIIGNGHLHKGAKPVHWCVDCRSAL ZileS GQRKDFIRLGVLGDWSHPYLTMDFKTEANIIRALGKIIGNGHLHKGAKPVHWCVDCRSAL VC0682 GQKESFKRLGILGEWDKPYRTMDFVTEANIIRALGKIADNGHLLKGFKPVHWCTDCGSAL HI0962 GQKKDFIRLGVLGDWDNPYLTMNFDTEANIIRTLGKVIENGHLYKGSKPVHWCLDCGSSL PM1662 GQKKDFIRLGVLGDWDNPYLTMNYHTEANIIRAFGKAVENGHLYKGSKPVHWCLDCASSL PA4560 GQKADFIRLGVLGEWDNPYKTMNFANEANEIRALAEMVKQDFVFKGLKPVNWCFDCGSAL NMB1833 RQKKDFIRLGVLGDWDHPYLTMDFKTEADTVRMLGEIYKSGYLYRGAKPVQFCLDCGSSL NMA0622 RQKKDFIRLGVLGDWDNPYLTMDFKTEADTVRMLGEIYKSGYLYRGAKPVQFCLDCGSSL XF2418 LQRRDFKRLGIIGDWDAPYKTLDFRFEADEIRALAKIVDKGHLIRGTKPVHWCFDCGSAL BU149 KQKKDFIRLGVIGDWDNPHLTMNFKNEANIIKTLSKIVQKKHLYQDFKPIHWCLKCASSL BS_ileS GQREQFKRLGVRGDWENPYVTLKPEYEAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESAL BH2545 RQREQFMRLGVRGDWWNPYVTLDKGFEAQQVKVFGEMAKKGYIYKGKKPVYWSPSSESAL L0350 MQRSDFKSLGVLADWDRPYLTLLPEYEAAQIRVFGKMAEKGYIYKGQKPIYWSPSSESSL SPy1513 KQRDDFKRLGVSADWENPYVTLDPQFEADQIRVFGAMAEKGYIYRGAKPVYWSWSSESAL sll1362 EQAVGFQRYGIWGDWKKPYLTLTPEYEAAQIGVFGAMALKGYIYRGLKPVHWSPSSRTAL aq_305 IQREDFVRLGVLGDWEHPYLTMDPKYEAQEIRELGKFFERGLAYRSKKPVYWCIYDKTAE TM1361 IQREEFKRLGVRGDWENPYITLKPDYEVKILDVFKTLVEQGNVYRSLKPIYWCPRCRTAL jhp1317 IQKNEFLQLGVLGDFEDPYKTMDFKFEASIYRALVGVAKKGLLKERHKPIYWSYACESAL HP1422 IQKNEFLQLGVLGDFEDPYKTMDFKFEASIYRALVEVAKKGLLKERHKPIYWSYACESAL Cj1061c IQREEFKDLGIIADWDKPYLTMKFEFEAAIYRTLCEIAKKGLLCERSKPVFWSWAAKSAL MG345 VQKEQFQRLGLLNDFQNCYYTIDESFQFKELELFLQAIKKGLIFQDLKPTYWSPISRTSL MPN520 IQKAQFQRLGLLNDFSKYYKTIDESFQQNELDLFLQAVKKDLIFQALKPTYWSPVSRTSL UU410 NQIQQFLRLGMISDFKQRYLTLDHNYEIDQLKLFTYMLKKGFIYQDFKPVFWSWSSQTAL PH1065 IMTEQFKMLGIWMDWDDPYMTIKNEYIESAWFTLKKAWEKGLLEKDKRVLHWCPRCETAL PAB0616 IMTEQFKMLGIWMDWDNPYMTIKNEYIESAWFTLKRAWEKGLLEKDKRVLHWCPRCETAL MTH1375 VMTGQFQRLGVWMDWDDPYVTFDPAYMESCWWTLKRAHEKDLLVRDLRVITWCPRCETAL MJ0947 IMEKQFKNLGVWLDWENAYMPITKEYMEIGWWTLKVAHEKGLLTRDLRVVYWCPRCETAL AF0633 AMTEQFKSLAVWMDWENPYMTIKAEYMNAAWFAIKRAHERGLLERKKMVVNWCHRCETAL APE0374 AMTRQFKEIGVFMDWENPYVTYRDEYIESGWWLVKKAWEKGLLYKGYRVLHWCPRCETTL Ta0879 EWKQVDDLIGFSIDHNGDYITLRNDYMESEWFALKTMYNSGLLYKDYTVVPYCPRCETSL TVN0829 EWKTVDQIIGFSIDHSGDYITLRNEYIESEWYVLKYIYENGLLYKDYTVVPYCPRCETSL CT019 EWKYFVDRIGRWVDFSATWRTMDLSFMESVWWVFRSLYDQGLVYEGTKVVPFSTKLGTPL CPn0109 EWEYYINRIGRWVDFSSTWKTMDASFMESVWWVFQSLYNQGLVYEGTKVVPFSTALGTPL TP0452 EWQRTLTRLGRWVDFDNDYKTMDVCYMESVWWVVAQLWQRKLLYEGYKILPYCPRCATAL BB0833 EWKNIILRLGRWVDFEKGYKTMDISFMESVWWVFKNLYEKGLIYESYYVLPYSPKLATPL Rv1536 EWQAYVTRQARWVDFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEGYRVLPYCWRDETPL ML1195 EWQAYVTRQARWVDFDNDYKTLDLSYMESVIWAFKQLWDKGLAYESYRVLPYCWRDETPL RP617 EWEQYVTRQARWVAFKNAYKTMDKNFMESVLWAFKELYNKDLLYESMRVMPYSWACETPL YBL076c DWRKTIGRLGRWIDFDNDYKTMYPSFMESTWWAFKQLHEKGQVYRGFKVMPYSTGLTTPL VNG2190G GLQSDFQSFGVWMDWDNPYKTVDPSYMEAAWWAFSEVHDNGLVERGQRSISQCPRCETAI DR1335 DWNELTERMGYWLDLGDPYITYQNSYVESVWNLLRRLHEKGLVAQDYKVVPLSPRISSTL YPL040c RQRETFQHFAILTDWETPYLTMDKDYEINQLNIFKEMYERGLIKRQNKPVYWGTETRTAL . . . . :. mlr8250 AEAEIE-----YQDYESD-TIWAKFPVANLVVANVVDGQPAELNPDLSDRSLDLLDAHVV CC0701 ADAEIE-----YHDHVSP-TIWVKFP--------VVQGSDAAVG------------AKLV ileS AEAEVE-----YYDKTSP-SIDVAFQ--------AVDQDALKAKFAVSNVN---GPISLV ZileS AEAEVE-----YYDKTSP-SIDVAFQ--------AVDQDALKAKFGVSNVN---GPISLV VC0682 AEAEVE-----YKNKVSP-SIDVRFK--------AADEAAVLAKFGLAAGHEGKGDVSIV HI0962 AEAEVE-----YEDKVSP-SIYVRFP--------AESADEIEAKFSAQGRGQ--GKLSAI PM1662 AEAEVE-----YEDKVSP-SIYVRFS--------AVDSDAVLAKFNATDKGT--GNISAV PA4560 AEAEVE-----YADKKSP-TIDVGFP--------VADADKLAAAFGLAALDK---PAQIV NMB1833 AEAEVE-----YKDKISP-AIDVAYL--------FKDTAALAAAFGLAGFEG---KAFAV NMA0622 AEAEVE-----YKDKVSP-AIDVGYP--------FKDTAALATAFGLAGIEG---KAFAV XF2418 AEAEIE-----YTDKTSP-MVDVAYP--------ALDPSALAAVFNATLPPD--VQLAVP BU149 SEAEIE-----YSKKKSD-SIIVGFK--------FKYKSIIEKLFDFQISNK--KEIHLL BS_ileS AEAEIE-----YQDKRSA-SIYVAFGVKDG-------KGVLE------------NGERII BH2545 AEAEIE-----YHDKRSP-SIYVAFPVKDG-------KNVLQ------------QDEKIV L0350 AEAEIE-----YQDVRSA-SIFVAFKAKDT-------KGKLP------------EDVEFV SPy1513 AEAEIE-----YHDIDST-SLYYANKVKDG-------KGILD------------TNTYIV sll1362 AEAELE-----YPEGHTSRSIYVSFPITQAG---EKAAEILAPYI---------DDLAVA aq_305 AEAEVE-----YYEKEDP-SIYVKFPLKSG--------EKFGIKD---------KKVFAI TM1361 AEAEIE-----YHDHKSP-SIYVKFRSK---------------ED---------PNFFIV jhp1317 AEAEVE-----YKMKKSP-SIFVAFDLK------KEGLEKLKVK-----------KASLV HP1422 AEAEVE-----YKMKKSP-SIFVAFGLK------KESLEKLKVK-----------KASLV Cj1061c AEAEVE-----YQDKEDY-SIFVAFDLD------VKACEKLGVS-----------KASAV MG345 AEAEIE-----YKEVNSI-ALYLTFKVSKSD--------FLDEN------------ANLL MPN520 AEAEIE-----YKEVKTI-GLYLTFTVVQSA--------VLNSG------------TKLL UU410 AESEIE-----YADRQSS-AIYVKMKVVDHND------LFTDKP------------TSLV PH1065 AEHEVRGE---YKLRKDP-SIYVKFPIEGK------------------------ENEYLL PAB0616 AEHEVRGE---YKLRKDP-SIYVKFPVEGK------------------------ENEYLL MTH1375 ALAEID-----YHDKEDP-SIYVKFPVSG--------------------------DTHIL MJ0947 AEHEVRGE---YKEVYDP-SVYVKFRLANE------------------------ENTYIV AF0633 ADAEVE-----YWDEEDP-SIYVKFPVKGE------------------------KDTYIV APE0374 ADYEVS-E---YRELEDP-SIYVKFPVEGR------------------------EGEYLL Ta0879 SSHEVAQG---YKDVKDP-SVYVRFKSA------------------------DEENTYFV TVN0829 SSHEVAQG---YKDVKDP-SVYVRFKEK------------------------GSENTYFV CT019 SNFEAGQN---YKEVDDP-SVVVKFALQ-------------------------DNQGFLL CPn0109 SNFEASQN---YKEVDDP-SLVVRMPLQ-------------------------NDSASLL TP0452 SNHELNLGG--YQDVSDP-AITVRFECTSVVP--GSPAAREFCAAASWGSASLPAHTCFL BB0833 SNFEVNLGE--YKEVNDP-SLTIKFKIK-------------------------DKNEYLL Rv1536 SNHELRMDDDVYQSRQDP-AVTVG-----FKV--VGGQP-----------DNGLDGAYLL ML1195 SNHELRMDDDVYQSRQDP-AVTLG-----FKV--LGGD------------DEDLVGAYLL RP617 SNFETRLDN-AYRERTDK-AITVSFVLNEVTL--INGIISQ---KSDMKEGDNFKEYRIL YBL076c SNFEAQQN---YKDVNDP-AVTIGFNVIGQ------------------------EKTQLV VNG2190G ANNEVE-----YEDVTDP-SIYVRFDLDD-------------------------REGSLV DR1335 SRAELG-EVDSYRMVDDP-SVYVRLPIVWDTLPERAHAALSSLS------GEQRQGLSLL YPL040c AEGELE-----YNENHKSIAAYVKFPLEKKSQ--MDLCKKLGITNN--------LPIYCL : * * mlr8250 IWTTTPWTIPGNRAVSYSPRVAYGLYEVTAAEN--AFGP--EPGEKLIFADALAAESQAK CC0701 IWTTTPWTIPANRAVSYNPDIPYSVFEVTALEEGLEFEPWAKPGDRLIIADKLAEDVFKA ileS IWTTTPWTLPANRAISIAPDFDYALVQIDG--------------QAVILAKDLVESVMQR ZileS IWTTTPWTLPANRAISIAPDFDYALVQIDG--------------QAVILAKDLVESVMQR VC0682 IWTTTPWTLPANRAVCLRADLEYVLIQVEGE-----------QPERIIVASELAKSVMDR HI0962 IWTTTPWTMPSNRAIAVNADLEYNLVQLGD--------------ERVILAAELVESVAKA PM1662 IWTTTPWTIPSNRAIAIHENLDYQLVQFND--------------ERVILAKDLVEEVAKA PA4560 IWTTTPWTIPANQALNVHPEIDYALVDAGD--------------RYLVLAEALVESCLAR NMB1833 IWTTTPWTLPASQAVSAGADVVYQLIDTPK--------------GKLVLAKDLAEDALKR NMA0622 IWTTTPWTLPASQAVSAGADVVYQLIDTPT--------------GKLVLAKDLAEDALKR XF2418 IWTTTPWTLPASLAISVGPTLDYVLVEGPTHSG---------QRRWLILAEALAAKALAR BU149 IWTTTPWTLPSSKAISIHPDFQYQLIETER--------------CYLIIAKELVEKTLNT BS_ileS IWTTTPWTIPANLGISVHPDLEYSVIAVGE--------------DRFVVASALVENVASA BH2545 IWTTTPWTIPANLGIAVHPELEYSVVAVKG--------------EKYVVASGLVETLESA L0350 IWTTTPWTIPSNLGIFAHPDYDYSVVAVNG--------------RKFVIASEMLEAVAEK SPy1513 VWTTTPFTVTASRGLTVGPDMDYLVVKPAGSD------------RQYVVAEGLLDSLAGK sll1362 IWTTTPWTLPGNLAVALNPELTYAVVETESHIF---------HRSYLIVALDLVEKLSET aq_305 IWTTTPWTLPANLGIMVKEDADYVLVEVED--------------EVWIVAKELMDKFFET TM1361 IWTTTPWTLPANVGIALHPDYEYSVVKVGE--------------EKWVIATDLLDAFSKE jhp1317 IWTTTPWTLYANVAIALKKDAVYALTQKGY-----------------LVAKALHEKLAAL HP1422 IWTTTPWTLYANVAIALKKDAVYALTQKGY-----------------LVAKALHEKLAAL Cj1061c IWTTTPWTLVANQAIALNPNENYVITKEGL-----------------IFASALLKSMVEK MG345 VWTTTPWTLPTNQAIAIHPDFDYLLFEYNQ--------------QKFVILEKLFEVFTNK MPN520 VWTTTPWTLPTNQAIAVHPQFEYLLFTYNN--------------EQYVVLASLFESLKTK UU410 IWTTTPWTLPANLAIAIHPELVYSLIEYKN--------------ENYIIAKPLVETFVKK PH1065 IWTTTPWTLPANLAVSAHPEYDYVKVKVEFNGKE----------EYWILAKALVDKVLGE PAB0616 IWTTTPWTLPANLAVSAHPDYDYVKVKVEFNGRE----------EYWILAKALVDKVLGE MTH1375 VWTTTPWTLPANMAVAVHPDFEYAYARLDG--------------ETYIMAEALVEKVLGE MJ0947 IWTTTPWTLVANLAVTVHPDYDYAYVEVEFDDKK----------EVWIIAEKLVEEVINK AF0633 IWTTTPWTLPANMAVAVHPSLEYAKFRAVKDGKV----------EYLILAKELADSVLGK APE0374 VWTTTPWTLPANAFVMAHPDMEYVKVRVGR--------------DTLILAKARLDHVMRE Ta0879 AWTTTPWTLPSNEFLVVNPDMEY--SLVEAQG------------SRYYVASSRAGYIFKE TVN0829 AWTTTPWTLPSNEFLVVNPDIEY--SLIEYNN------------AKYYVASSRAQYIFKD CT019 AWTTTPWTLVSNMALAVHPELTYVRIKDKESG------------DEYILGQESLPRWFPD CPn0109 VWTTTPWTLPSNMAIAVGETLVYVRIQDKKSG------------EQWILSQGCVSRWFSN TP0452 AWTTTPWTLPCNAALALGPQILY--VLIEAND------------EHYILARSRLEFYYPD BB0833 VWTTTPWTLPSNLGIAVGQEIEYSKIFDKTKE------------EILILGSKKLNSYYDD Rv1536 VWTTTPWTLPSNLAVAVSPDITY--VQVQAGD------------RRFVLAEARLAAYARE ML1195 VWTTTPWTLPSNLAVAVHPDVTY--VDVRAGD------------RRFVLAQARLTAYARE RP617 AWTTTPWTLPANLALAVGSDIDY--AFVDKNE------------VCYIIAASSVAKYAKE YBL076c AWTTTPWTLPSNLSLCVNADFEYVKIYDETRD------------RYFILLESLIKTLYKK VNG2190G VWTTTPWTIPANQFVAVDEDGDYQQVRATTPDGE---------TDVLYVASECVEDVLSA DR1335 VWTTTPWTLPSNTLAAVNPDLDYVVADSPS--------------GRVIVAEGAVERLSAL YPL040c IWTSTPWTLLSNRAICFNQDFSYSLLRLNS--------------ELILVETGSIDKLGLT **:**:*: . * . mlr8250 AKIT-----LKRLHHVSAEQLGNLVLSHPFKG---LGGGY----------EFPVPMVAG- CC0701 AKVA-----SWKT--VEAVDCEGMVLAHPLAD---LDSHY----------GYAVPMLAG- ileS IGVTD----YTILGTVKGAELELLRFTHPFM-------------------GFDVPAILG- ZileS IGVTD----YTILGTVKGAELELLRFAHPFM-------------------GFDVPAILG- VC0682 AGIEH----FHNLGFATGADLELVQFQHPFY-------------------SFTVPAILG- HI0962 VGIEH----IEILGSVKGDDLELSRFHHPFY-------------------DFTVPVILG- PM1662 AGVEQ----VVILGESKGKDLEWLRFQHPFY-------------------DFSVPFILG- PA4560 YQRE-----GKVVATAKGEALELINFRHPFY-------------------ERLSPVYLA- NMB1833 YGFSDG---IAILAETTGDKLENLHMNHPFL-------------------ERDIPMLNG- NMA0622 YGFSDG---IAILAETTGDKLENLHMNHPFL-------------------ERDIPMLNG- XF2418 YGIAE----LLIHGSAKGAAMEQHILAHPFYP------------------DRTIPLLLG- BU149 LKIKK----SIIRNYVKGRFLEKMICLHPFLK------------------NIDLPVILG- BS_ileS CGFDQ----YEVTRTVKGKDLENIIAEHPLY-------------------GRDSLVMLG- BH2545 LEWEN----PEILRTIKGVDLEYVVAEHPIY-------------------GRDSLVVLG- L0350 LEWEN----PEVLQTIKGSELEYMVAKHPFY-------------------DRETLIMNA- SPy1513 FGWES----FETLASHKGADLEYIVTEHPWDT------------------DVEELVILG- sll1362 FGVK-----LTVKVTLQGESLENTCYQHPLFD------------------RVSPIVIGG- aq_305 VNRPE----GLVLETVKGKDLVGLEYTHPFVE------------------KEKLKGHLSE TM1361 TGIDC----SNVVEKIKGKDLEGKEFVHPIFD------------------DRTSR----- jhp1317 GVVDN-----AITHEFNSNDLEYLVATNPLN-------------------QRDSLVVLG- HP1422 GVVDN-----EITHEFNSNDLEYLVATNPLN-------------------QRDSLVALG- Cj1061c GLTSG-----EIQKELNAKEFEKLEAINPLN-------------------GRKSVLIMG- MG345 LNWTN----AIKLKKFKGSNLKNSSYSHCFY-------------------NKVLPVLMG- MPN520 FGWTD----AIQVQTISGSQLQNTTYKHCLY-------------------DKVNPVLLG- UU410 VGFED----YKWIKDFKANTLEKIKYISPIS-------------------KKHAFVIMD- PH1065 IG-----VKGEVIEEFKGRELEGLRYIHVLMDEYPRQKEFREK------YEWAHRIILA- PAB0616 IG-----VKGEVVEEFKGRELEGLRYVHILMDEYPRQKEFKEK------YEWAHRVILA- MTH1375 E--------AEILKRVKGTELEGLTYRHPLDDEVPLHR------------EIEHRVILG- MJ0947 AKKFHNIKNYKIIKKVKGKELEGIKYIHPLLEENERQKEFAE-------LENAHTVILG- AF0633 GD----YDSWEVVETYLGEDLEGLEYEHPLADEVPLQK------------NWKHQVFFA- APE0374 AG----VSEYEVLEVLKGSQLEGLRYRHPLEDVVDAQRELS---------KWHKVVMAP- Ta0879 YREI---------RRMHGRDLVGKRYLQLMPF---LDPPS-----------GSLKVVAG- TVN0829 FKVL---------KKMKGFELAGKGYEQLLPF---LDPPA-----------GALRVVTG- CT019 RESY------EWIGQLSGKSLVGQSYEPLFPY--FQDKKE----------LEAFRILPA- CPn0109 PEEF------VILESFSGKDLVGRTYEPPFTF--FQSKRE----------EGAFRVIAA- TP0452 SSAY------RVVWEKRGEHLAGIRYRPLFSYPVFGQGPDPSVQG--DSEEGLFCTRVA- BB0833 ENSY------TIIEKFKGSKLEGIEYEPIFNY--FLEQKD----------KGAFKVHTA- Rv1536 LGEE-----PVVLGTYRGAELLGTRYLPPFAY--FMDWP------------NAFQVLAG- ML1195 LGDE-----PEVLATYRGADLLGRHYLPPFQY--FYESAR-----------NAFQVLPG- RP617 LGLSG----KENFEIIKGLKLQGLSYKPLFNY--FENHP------------NSFKIFAS- YBL076c PKNEK----YKIVEKIKGSDLVGLKYEPLFPY---FAEQFH---------ETAFRVISD- VNG2190G GGYSD----HEIVADHSGSDLIGWSYTPPLADAVPAN-PTD--------ADGTHEVYHG- DR1335 HKDAAP---LEVLARFKGRDLEWVEYEPPFPEVASQLGVVSELHERRDGKPVLHFVVMA- YPL040c TNS------FETIKQFQGTHLNGLYYQNLLVDD-----------------KVGRPLLHG- . mlr8250 ------------DHVTDDAGTGFVHTAPGHGREDFDAW-MDAAPQLRARGIDTVIPFTVD CC0701 ------------DHVTDDAGTGFVHTAPGHGADDYQVW-LAHG--------HREIPDTVD ileS ------------DHVTLDAGTGAVHTAPGHGPDDYVIG-QKYGL---------ETANPVG ZileS ------------DHVTLDAGTGAVHTAPGHGPDDYVIG-QKYGL---------ETANPVG VC0682 ------------DHVTTDSGTGVVHTAPGHGQEDFAVG-QQYGL---------EVANPVG HI0962 ------------DHVTTDGGTGLVHTAPDHGLDDFIVG-KQYDL---------PMAGLVS PM1662 ------------DHVTTDGGTGLVHTAPDHGHDDYIIA-QKNGI---------EMAGLIG PA4560 ------------DYVALDAGTGIVHSSPAYGEDDFYTC-KRYGMS------NDDILSPVQ NMB1833 ------------EHVTTDAGTGLVHTAPAHGLEDYAVC-NKYGI---------ELYNPVN NMA0622 ------------EHVTTDAGTGLVHTAPAHGLEDYAVC-NKYGI---------ELYNPVN XF2418 ------------NHVSAEDGTGAVHTAPGHGQEDHQVF-QQYGLLNH---YSAAELNPVD BU149 ------------KHVTLESGTGAVHTAPDHGLEDYIIS-QKYNI---------KTSNIVN BS_ileS ------------EHVTTDAGTGCVHTAPGHGEDDFIIG-QKYG---------LDVLCPVD BH2545 ------------DHVTLDAGTGCVHTAPGHGEEDYIVG-QKYG---------LDVLCPVD L0350 ------------DYVTLDSGTGLVHVAPGHGEDDYFAS-RKYK---------LPVLSPID SPy1513 ------------DHVTLESGTGIVHTAPGFGEDDYNVG-TKYK---------LEVAVTVD sll1362 ------------DYVTTESGTGLVHTAPGHGQEDYVVG-QRYG---------LPILSPVD aq_305 ETLKNMWKIYPSEFVSLDTGTGLVHMAPGHGQEDYVVG-QRYG---------LEPYAPVS TM1361 --------VILADYVSLETGTGCVHIAPGHGEEDYIYGHVQYG---------LPIVSPVD jhp1317 ------------DHVSLEDGTGAVHTAPGHGEEDYYLG-LKYH---------LEVLMSVD HP1422 ------------EHVGLEDGTGAVHTAPGHGEEDYYLG-LRYN---------LEVLMSVD Cj1061c ------------EHVLMDGGSGLVHTAPGHGEDDYYAC-LKYG---------IEVLMPVD MG345 ------------IHVVDNEGTGIVHSSPAFGIDDFYLCQKNKIK---------EVLISID MPN520 ------------NHVLCNEGTGLVHTSPAYGLDDFYLCKQNKLN---------EALVSLD UU410 ------------EYVSANDGTGLVHNAPAFGLEDYYACKKYGI----------ETVVMID PH1065 ------------DFVTLEEGTGLVHTAPGHGEEDFEVG-KKYG---------LPIYSPVD PAB0616 ------------DFVTLEEGTGLVHTAPGHGEEDFEVG-QKYG---------LPVYSPLD MTH1375 ------------DHVTLTEGTGCVHTAPGHGPEDFEIG-KKYG---------LEVICPVD MJ0947 ------------EHVTLEGGTGLVHTAPGHGEEDFEVG-KKYN---------LPIYSPID AF0633 ------------DFVTAEN-TGCVHIAPGHGVEDYELG-VEKG---------LEVFNPVD APE0374 ------------EAVTPHEGSGLVHSAPGHGTIDYEIA-QRIG---------APVVSLVD Ta0879 ------------SFVTSEDGSGIVHAAPAFGADDYQIG-KEEG---------VEILNPVD TVN0829 ------------DFVTDIDGSGIVHAAPAFGSDDYQIG-KREN---------VPILNPVD CT019 ------------DFIEESEGTGIVHMAPAFGEADFFAC-QEHN---------VPLVCPVD CPn0109 ------------SFVEESEGTGVVHMAPAFGEGDFLVC-KENH---------VPLVCPVD TP0452 ------------DFVSTEDGTGVVHVAPAFGEDDYEVF-KDAG---------ISIQCPLD BB0833 ------------DYVTTDDGTGIVHIAP-FGEEDYRIL-KKHTN--------VDIIDPLD Rv1536 ------------DFVTTDDGTGIVHMAPAYGEDDMVVA-EAVG---------IAPVTPVD ML1195 ------------DFVTTDDGTGIVHIAPAYGEDDMATA-DKVG---------IVPVTPVD RP617 ------------DFVVEGDGTGIVHMAPGFGEDDQILC-ESKG---------IELVCPVD YBL076c ------------DYVTSDSGTGIVHNAPAFGEEDNAAC-LKNGVISE----DSVLPNAID VNG2190G ------------DWVEADR-TGLVHSAPGHGEEDFERG-AELD---------LPVFCPVG DR1335 ------------DFVSDVDGSGVAHEAPAYGAEDLEVA-RAYG---------VPLMFGVD YPL040c ------------AHVTSGTGTGLVHTAPGHGQDDYLIG-IQNG---------LEIYSPVD : :* .* :* .* * : mlr8250 DAGFFTRDAPGFGP---DREGGAAR-VIDDNGKKGNANQAVIDELIKR-NA-------LF CC0701 PDGAYYPHVALFAG---LKVLETE---GKKVGKFGPANGAVMEKLIEA-GN-------LL ileS PDGTYLPGTY-------PTLDGVN---------VFKANDIVVALLQEK-GA-------LL ZileS PDGTYLPGTY-------PTLDGVN---------VFKANDIVVALLQEK-GA-------LL VC0682 SNGVYLPDT--------ELFAGQH---------VFKANDSVLEVLKEK-GA-------LL HI0962 NDGKFISTT--------EFFAGKG---------VFEANPLVIEKLQEV-GN-------LL PM1662 NDGLFKADV--------PFFAGKG---------VFESNDLVVAKLQEV-GA-------ML PA4560 SNGVYVDSL--------PFFGGQF---------IWKANPNVVAKLEEV-GS-------LL NMB1833 AEGRYIGET--------PRVAGMR---------VWEANPVILQWLEET-GN-------LL NMA0622 AEGKYIGET--------PRVAGMR---------VWEANSVILQWLEET-GN-------LL XF2418 ARGVYLPTTPPFSE---LTLAGLH---------IWKANPLIVDALRLR-GV-------LL BU149 FKGEYISNTH-------DKLDGVN---------VLEANSIIIELLIKN-NT-------FF BS_ileS EKGVMTSEA---------PGFEG--------MFYDDANKAITQQLDEK-GA-------LV BH2545 DKGYMTAEA---------PGFEG--------LFYDEANKPITQKLDEC-GA-------LL L0350 NRGYYTDEA---------PGLEG--------LLYDEGNKVVSKWLEEK-DA-------LL SPy1513 ERGLMMENAG--------PDFHG--------QFYNKVTPIVIDKLG---DL-------LL sll1362 AAGNLTEEAG--------KFAGL--------NVLNDANEAIINALQDQ-KV-------LL aq_305 DEGRFVEPAP--------EFLIN--------VRVFDANHLIVGVLKEK-GF-------LV TM1361 EEGRFTEEAG--------KYKG---------MFIEDANEVIIEDLKRK-GI-------LV jhp1317 EKGCYDEGI---IH---NQLLD----KSYLGEHIFKAQKRIIEQLG---DS-------LL HP1422 EKGCYDEGI---IH---NQLLD----ESYLGEHVFKAQKRIIEQLG---DS-------LL Cj1061c DSGCYDETL---RA---KGLLPSHLLEEFIGLHIFKANEKILELLG---EK-------LL MG345 EKGVFNNLLN-------DKELEN--------CFYLKANDLIINRLKQN-NS-------FI MPN520 EKGVFNDTLN-------DPVLTG--------LFYLKANDVIIERLKQH-HN-------FV UU410 QFGKYNALVN-------DLELEN--------MFYEDANQVILNRLMNE-HL-------LI PH1065 DQGRYVE----------GKWKGIYVK---------EADPQIIEHLKEK-GY-------LV PAB0616 DQGKYTE----------GKWKGIYVK---------EADPKIIEHLREK-GY-------LV MTH1375 EAGIFTEEA--------GKYSGRFVK---------DADEDIIADLRSK-GL-------LL MJ0947 DEGKYVE----------GKWKGVFVK---------DADAEIIETLKNK-GL-------LV AF0633 DRGVYTEEA--------GKYAGKHVK---------EANDDIIDDLYRK-DL-------LL APE0374 ERGFMTEAA--------GKYSGLYFRG--------EANKAIVEDLRAR-GA-------LF Ta0879 KNGRFADPR--------IPWNGKFVR---------DANEDIIVYLKKN-QM-------LL TVN0829 KNGRFSDER--------LPWYGKKVR---------EANEDIIVYLKNN-GL-------LI CT019 NQGCYTAEV--------KDFVGEYIK---------SADKGIARRLKNE-NK-------LF CPn0109 AHGSFTEEI--------PQYQGQYIK---------HADKEIIKFLKKE-GR-------IF TP0452 AECRFTAEV--------ADYQGLFVK---------AADKAIIARVQKQ-GA-------LF BB0833 AECKFTNQV--------KDFKGLFVK---------DADKKIIENLKLR-NF-------LF Rv1536 SKGRFDVTV--------ADYQGQHVF---------DANAQIVRDLKTQSGPAAVNGPVLI ML1195 SNGCFDATV--------PDYQGQHVF---------EANAQIIRDLKNQSGSAAVNGAVLL RP617 NSGKFTKEI--------PDLEGVQVF---------DANDKIIIKLKEQ-GN-------WI YBL076c DLGRFTKDVP--------DFEGVYVK---------DADKLIIKYLTNT-GN-------LL VNG2190G EDGVYTDAG--------GKYAGAFVR---------DANDDIIADLEAR-DA-------ML DR1335 DHGILQVT----------HEQGKFFK---------DADKGLIADMKAR-GL-------MF YPL040c HQGRYQLNELPQSVRSIVRDEGDLTKGRQ--VLDAETAKIILCKLSDL-NL-------LY : : mlr8250 ARGRLKHSYPHSWRSKKPVIFRNTPQWFVYMDKDLG--DG--TTLRSRALKAID-DTRFV CC0701 ARGRVEHSYPHSWRSKAPVIFRNTPQWFIRMDHAVDSLDG--KTLREVAVQAIA-DTAFY ileS HVEKMQHSYPCCWRHKTPIIFRATPQWFVSMDQK---------GLRAQSLKEIK-GVQWI ZileS HVEKMQHSYPCCWRHKTPIIFRATPQWFVSMDQK---------GLRAQSLKEIK-GVQWI VC0682 HHHAYEHSYPHCWRHKTPIIFRATPQWFVSMEQA---------GLREQALTAIK-GVHWM HI0962 KVEKIKHSYPHCWRHKTPIIFRATPQWFIGMETQ---------GLRQQALGEIK-QVRWI PM1662 KFSKIKHSYPHCWRHKTPIIFRATPQWFIGMEKQ---------GLRQQALSEIK-KVRWI PA4560 AHETINHSYMHCWRHKTPLIYRATAQWFVGMDKQPR--QG--ASLRERALEAIT-QTEFV NMB1833 ASSKIEHSYAHCWRHKTPLIYRATGQWFVGMDKAGA--DG--KTLRDKAIKAVD-DTEFF NMA0622 ASSKIEHSYAHCWRHKTPLIYRATGQWFVGMDKAGA--DG--KTLRDKAIKAVD-DTEFF XF2418 AAAEMHHSYPHCWRHKTPIVFRATPQWFISMEQA---------ALRSAALKAIT-HVTWY BU149 HHESLIHSYPHCWRHKSPVIYRATPQWFIDIDQK---------QLRIKLLQEIK-KVRWI BS_ileS KLEFITHSYPHDWRTKKPTIFRATAQWFASIKDF-----------RSDLLDAIK-ETKWV BH2545 KLTFITHSYAHDWRTKKPVIYRATAQWFASIENF-----------RDELLRAIQ-EVKWV L0350 KLEFFTHSYPHDWRTKKPVIFRATPQWFASIDDF-----------RQNILDEVE-RVDWV SPy1513 AQEVINHSYPFDWRTKKPIIWRAVPQWFASVSDF-----------RQDILDEIE-KTTFH sll1362 KEEAYEHKYPYDWRTKKPTIFRATEQWFASVEGF-----------RDQALKAIK-EVTWI aq_305 HEEKIRHSYPHCWRCKNPVIFRATPQWFIGMDIEFF---G--KTLRQRALEEIE-KVKWI TM1361 HASSITHSYPHCWRCKGPVIFRATEQWFISVDHN---------NLRQKVLEEID-KVKWI jhp1317 LEREIEHSYPHCWRTHKPVIYRATTQWFILMDEPFIQNDGSQKTLREVALDAIE-KVEFV HP1422 LEQEIEHSYPHCWRTHKPVIYRATTQWFILMDEPFIQNDGSQKTLREVALDAIE-KVEFV Cj1061c HSSKFIHSYPFCWRTHKPVIYRATKQWFILMDEPKLQG----KTLRECAKEQLL-KTTFY MG345 FSEVISHREPHDWRSKTPVIYRASKQLFIKTKSI-----------KKQLKKQIN-QVNFL MPN520 FSESFLHREPHDWRSKTPVIYRASKQLFIKTKSI-----------QSKLKRQIK-RVKFV UU410 HHEVITHSVAHDWRTKKPVMYRATKQWFVSIEKI-----------LPNILQTLNNDVKST PH1065 KAGEIEHKYPHCWRCKTPLIFRATDQWFLKVSKV-----------KDRIIKENDEKVTWY PAB0616 KAGEIEHKYPHCWRCKTPLIFRATDQWFLKISKV-----------KDKIIKENDEKVTWY MTH1375 KAGTISHRYGFCWRCKTPIIYLATEQWFLKITEI-----------KDKMLRELD-RVQWV MJ0947 YAGKIKHSYPHCWRCKTPLLFRATEQWFLEISKI-----------KDNIIEHAK-TVQWI AF0633 AEERIVHRYGHCWRCKTPIIYRATEQWFIKISEL-----------KDEMLEEID-KVMWI APE0374 HAATIVHRYPVCWRCKTPLLLRATTQWFVAVTRL-----------KNQLMREAE-KVEWQ Ta0879 KSEKYEHSYPFCYRCDTPLLYYPLDAWFIAVSRI-----------RDKLVEYNE-RINWK TVN0829 KSEKYEHSYPFCYRCDTPLLYYPLDAWFIRVSSV-----------RDKLVENNE-KIRWK CT019 YQGTVRHRYPFCWRTDSPLIYKAVNSWFVAVEKV-----------KSKMLKANE-SIHWT CPn0109 YHGTVKHRYPFCWRTDTPLIYKAVNSWFVAVEKI-----------KDKMLRANS-SIHWV TP0452 RREQISHAYPHCWRCASPLIYRAVHSWFVAVEKI-----------KDKMLAANA-SICWQ BB0833 KRENYLHRYPFCYRTNCPIIYRPISSWFVNVEKI-----------KTKLLEVNE-KINWM Rv1536 RHETYEHPYPHCWRCRNPLIYRSVSSWFVRVTDF-----------RDRMVELNQ-QITWY ML1195 RHETYEHPYPHCWRCRNPLIYRAVSSWFVAVTEF-----------RDRMVELNQ-QITWY RP617 KTEQYIHNYPHCWRTDTPLIYKAVPSWYVRVTKF-----------KDRMVELNQ-QINWI YBL076c LASQIRHSYPFCWRSDTPLLYRSVPAWFVRVKNI-----------VPQMLDSVM-KSHWV VNG2190G ASQTVEHSYGHCWRCDTGIIQIVTDQWFITITDV-----------KDELLANMD-TSEWH DR1335 WAGTLKHRYPFHDRTGDPILYFAKKGWYIRTSQV-----------AGEMLAQNE-KINWV YPL040c KSHEYTHSYPYDWRSKKPVIIRATPQWFADLHDV-----------KNLALESIS-RVKFC * * : : mlr8250 PAAG-QNRIRAMIEERPDWVLSRQRAWGVPIAVFADED-G--NVLKD-EAVNQRIMDAFE CC0701 PDGG-RNRIGAMVETRPDWLISRQRNWGTPLAMFVDKHTG--HPLND-PEVNARILAAIR ileS PDWG-QARIESMVANRPDWCISRQRTWGVPMSLFVHKDTE--ELHPRTLELMEEVAKRVE ZileS PDWG-QARIESMVANRPDWCISRQRTWGVPMSLFVHKDTE--ELHPRTLELMEEVAKRVE VC0682 PDWG-QSRIEGMVAGRPEWCISRQRTWGVPIALFVHKETA--ELHPNSADLIEKVAQLVE HI0962 PDWG-QARIEKMVENRPDWCISRQRTWGVPMTLFVHKETE--ELHPRTLDLLEEVAKRVE PM1662 PDWG-QARIEKMVENRPDWCISRQRTWGVPVALFIHKETE--ELHPRTVELVEEVAKRVE PA4560 PGWG-QARLHGMIAGRPDWCISRQRNWGVPIPFFLHKASG--ELHPRTVELMEEVAQRVE NMB1833 PSWG-RARLEAMIEGRPDWVVSRQRYWGTPMTFFVHKETG--ELHPNSAELLEKVALKIE NMA0622 PSWG-RARLEAMIEGRPDWVVSRQRYWGTPMTFFVHKETG--ELHPNSAELLEKVAQRIE XF2418 PQWG-QARILSMIENRPDWTISRQRTWGVPIPLFVHRHSG--APHPRSAALMRQVADRVE BU149 PEWG-ESRIGEMIKKRPDWCISRQRKWGVPMSIFIHKNTR--KIHPNTFVFMKKIAKKVE BS_ileS PEWG-EQRLHNMVRDRGDWCISRQRAWGVPIPVFYAEN-G--EPVIT-DETIEHVSELFR BH2545 PEWG-ETRLYNMVRDRGDWCISRQRVWGVPIPIFYGEN-G--EPIIT-DETINHVSELFR L0350 IPWG-KTRLFNMVRDRGDWVISRQRAWGVPLPIFYGEN-G--EPIIT-PETTEHVAKLFA SPy1513 PSWG-ETRLYNMIRDRGDWVISRQRAWGVPLPIFYAED-G--TAIMT-KEVTDHVADLFQ sll1362 PTQG-ENRITPMVGDRSDWCISRQRAWGVPIPVFYDEETS--EPLLT-EETINHVQQIIA aq_305 PEYG-KNRIKSMVENRPDWCISRQRFWGVPITVFYCENCG--EIIKD-REVFERVAQLVE TM1361 PEWG-RNRIRSMVEERPDWCISRQRVWGTPIPAVKCKECG--EVVLD-PKVIEHFMKIVE jhp1317 PSSG-KNRLKTMIENRPDWCLSRQRKWGVPLAFFIDKRTN--KPCFE-SEVLEHVANLFE HP1422 PSSG-KNRLKTMIENRPDWCLSRQRKWGVPLAFFIDKRTN--KPCFE-SEVLEHVANLFE Cj1061c PQSG-VKRIGSMVENRPDWCISRQRDWGTPIAFFRDKNTK--EVIFD-DELFDFVAAIFE MG345 NSKN-QLRLKEMLLQRDEWCISRQRVWGLPIPIVYANN----K-PLLDFSTIQYTIKQLK MPN520 NNKN-KERLQEMLLQRAEWCISRQRVWGLPIPLIYADN----Q-PLLDVTTIKYTIQQLK UU410 SFRG-IERMHEMIVNRKEWCISRQRVWGVPIPMIFDEN----HNAIMDHELVENIINVLN PH1065 PDWV-KIRFDNGVRDSGDWVISRQRYWGIPLPIWQSEDG----E-IYVVGSWRELVELAV PAB0616 PDWV-KIRFDNGVRDSGDWVISRQRYWGIPLPIWQSEDG----E-IYVVGSWRELVELAV MTH1375 PSWAGESRFRNWIENARDWTISRQRYWGIPIPIWICEEC----DSIHVVGSIDELRELAV MJ0947 PHWV-ETRYINGVKFVGDWNISRQRYWGIPIPVWVCEKC----GKYIVVGSVEELEEKMI AF0633 PEWAGSARFKDWVSNAKDWCISRQRYWGIPIPVWICEKC----GEMKVVGSINEI----- APE0374 PGWA-KTRFMNMLRELRDWVISRQRYWGIPLPVWRCSSC----GYEHVVGSVEEL----- Ta0879 PDYLKHGRFGNFLGEAKDWNLSRDRFWGTPLPAWRCKN-----GHLVFVGSRKEIEDL-- TVN0829 PDYLKHGRFGNFLDEAKDWNLSRDRFWGTPLPVWRCRN-----NHVRFIGSRKEIEEM-- CT019 PEHIKQGRFGKWLEGARDWAISRNRYWGTPIPIWRSDD-----GELLVIGSIQELEAL-- CPn0109 PEHIQEGRFGKWLEGARDWAISRNRYWGTPIPIWKSAD-----GEILVVGSIRELEEL-- TP0452 PSHIRDGRFGKWLVCARDWAISRDRYWGNPLPIWRCVHC----GATDCIGSRTQLYER-- BB0833 PAHLKKGRFGKWLENAKDWAISRNRFWGNPIPIWICSKT----GKKICIGSKKELENL-- Rv1536 PEHVKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPA--YPRIDVYGSLDELERD-- ML1195 PEHVKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPD--YPRIDVYGSLDELERD-- RP617 PHNVKDNLFGKWLENARDWSISRNRFWGTPLPVWKSDDPK--YPRIDVYGSIEEIEKD-- YBL076c PNTIKEKRFANWIANARDWNVSRNRYWGTPIPLWVSDD----FEEVVCVGSIKELEEL-- VNG2190G PEWARDNRFRDFVENAPDWNVSRQRYWGIPVPIWTPEDWSGDAEDVLVVGTREELAALAD DR1335 PGNIKHGRFGNWLEGNVDWAISRERYWGTPLPFWQSES-----GQLRVIGSVAELSELAG YPL040c PKRG-YSRLSSFMKSRNEWCISRQRSWGIPILSFYKKSEP--DSVLMNSEILAHAIEKIK : :* :**:* ** *: mlr8250 ---EEGA----------------------DAWFAAG--AKERFLGN------HDASKWKQ CC0701 ---EGGA----------------------DAWFTR---PDADFLGA------HDPAQYEK ileS ---VDGI----------------------QAWWDL---DAKEILG-------DEADQYVK ZileS ---VDGI----------------------QAWWDL---DAKEILG-------DEADQYVK VC0682 ---QKGI----------------------QAWWDL---DTAELLGA------EDAANYEK HI0962 ---RAGI----------------------QAWWDL---DEKELLG-------ADAETYRK PM1662 ---QKGI----------------------QAWWDL---DTAELLG-------ADADNYIK PA4560 ---KEGI----------------------EAWFKL---DAAELLG-------EEAAQYEK NMB1833 ---EKGI----------------------EAWFSL---DKSELLSA------EDCENYDK NMA0622 ---EKGI----------------------EAWFSL---DKGELLSA------EDCEHYDK XF2418 ---QQGV----------------------DIWYSL---DQTELLG-------TEADQYEK BU149 ---LEGL----------------------QVWWNI---DSKEILG-------EEYQSYEK BS_ileS ---QHGS----------------------NIWFEK---EAKDLLPEGFTHPGSPNGTFTK BH2545 ---KHGS----------------------NVWFEW---ETKDLLPEGFTHESSPNGQFTR L0350 ---EFGS----------------------KVWFER---EAKDLLPEGFTHPASPNGEFTK SPy1513 ---ENGS----------------------IIWWQK---EAKDLLPEGFTHPGSPNGEFTK sll1362 ---EKGS----------------------DAWWEL---TVEELLPEAYRNNGR---TYRK aq_305 N-SEKGS----------------------DVWFEL---TSSQLLPEGYKCPKCGGDSFTK TM1361 ---KEGT----------------------NAWFEK---EVEELIPEDFVCPKCGKRSFEK jhp1317 ---EKGC----------------------DVWWEY---NIKDLLPPS---YQDNAKHYEK HP1422 ---KKGC----------------------DVWWEY---SVKDLLPPS---YQEDAKHYEK Cj1061c ---KHGA----------------------DAWWEF---EIKDLIPTN---SKYKAENLEK MG345 ---KHGI----------------------DSWFEK---DVTCFLKPDKT---KKWVKYHK MPN520 ---KYGI----------------------DSWFEK---DINFFLNPKKI---QPGVEYKK UU410 ---EKGV----------------------NAWFDL---DVNAFLTPKYLS--MKNKTFYK PH1065 AIEVNGERIDLPESYEEKLKVIEEKLGPEDLHRPYV--DAFIIKVN--------GKEMRR PAB0616 AIEVNGERIELPESYEEKLKVIEEKLGPEDLHRPYV--DAFIIKVN--------GKDMRR MTH1375 EGELEG----------------------DFIHRPHV--DRIVLECGE------CGGRMKR MJ0947 NKDEVG--------------------EINDLHKPTV--DKIKLRCE-------CGGEMKR AF0633 --EWEN---------------------DLDLHRPKI--DAVTFSCQ-------CGGVMRR APE0374 --ESMGGR------------------RPENLHRPWV--DRVELKCPR------CGGSMKR Ta0879 ----GGKV-------------------PEDLHRPYI--DEVRFKCP------TCGEEMSR TVN0829 ----GATV-------------------PQDLHRPYI--DEVKFVCP------DCGEEMRR CT019 ----SGQK-------------------IVDLHRHFI--DEIEIN--------QNGKSFRR CPn0109 ----TGTQ-------------------ITDIHRHFI--DDLNIV--------KDGKPFHR TP0452 ----SGML-------------------LEDLHKHVV--DMVTIPC-------ACGSVMRR BB0833 ----SGQK-------------------IEDLHKDQI--DKITWPS-------KDGGKFIR Rv1536 ----FGVR-------------------PANLHRPYI--DELTRPNPDDP---TGRSTMRR ML1195 ----FGVR-------------------PTNLHRPYI--DELTRPNPDDP---TGLSTMRR RP617 ----FGVK-------------------INDLHRPFI--DELTRTNPDDP---TGKSTMRR YBL076c ----TGVRN------------------ITDLHRDVI--DKLTIPSK------QGKGDLKR VNG2190G QDVDPAS---------------------VDLHKPTV--DDITIT--------EDGTEYTR DR1335 ---RDLS--------------------DLDLHRPYI--DDITFT--------LDGEEYRR YPL040c ---QKGI----------------------NAWFNDKDNDMKEWLPEKYH---DVAHEYCR : mlr8250 VMDILDVWFDSGSTHVFTLE---DRP----D-----------LKWPADVY---LEGSDQH CC0701 ITDILDVWFDSGCTHAFTIE---GRA----D-----------SAWPADLY---LEGSDQH ileS VPDTLDVWFDSGSTHSSVVD---VRP---EF-----------AGHAADMY---LEGSDQH ZileS VPDTLDVWFDSGSTHSSVVD---VRP---EF-----------AGHAADMY---LEGSDQH VC0682 VLDTLDVWFDSGVTHSAVVD---ARQ---EF-----------NGAEADMY---LEGSDQH HI0962 VPDTLDVWFDSGSTYSSVVA---NRL---EF-----------NGQDIDMY---LEGSDQH PM1662 VPDTLDVWFDSGSTYYSVVK---DRP---EF-----------NGQEADMY---LEGSDQH PA4560 INDTLDVWFDSGTTHWHVLRGS-HRIG--HA-----------SGPVADLY---LEGSDQH NMB1833 LSDTMDVWFDSGSTHYSVVK---QRE----E-----------LEWPADLY---LEGSDQH NMA0622 LSDTMDVWFDSGSTHYSVLK---QRE----E-----------LDWPADLY---LEGSDQH XF2418 ITDILDVWFDSGITHEAVLL---ERG----------------LPKPADLY---LEGADQH BU149 ILDILDVWFESGNTHTTINYK--NKN----Y-----------TKKNADMF---LEGSDQH BS_ileS EQDIMDVWFDSGSSHQAVLEER-DD-----------------LVRPADLY---LEGSDQY BH2545 EMDIMDVWFDSGSSHQGVLVER-EE-----------------LDRPADLY---LEGSDQY L0350 EKDIMDVWFDSGSSWNGVLNER-DY-----------------LSFPADLY---LEGSDQY SPy1513 ETDIMDVWFDSGSSWNGVMNTK-EN-----------------LSYPADLY---LEGSDQY sll1362 GEDTMDVWFDSGSSWAAVANAK-NRP----------------LKYPVDMY---LEGSDQH aq_305 EEDILDVWFDSGCS--HAAVIR-PL-----------------GFQKADLY---LEGSDQH TM1361 MLDTLDVWIDSGASFEYITTKR-ED-----------------HPFPLDMY---LEGSDQH jhp1317 VMHILDVWFDSGSTFKAVLEDY-HGE----K-----------GQSPSDVV---LEGSDQH HP1422 IMHILDVWFDSGSTFKAVLEDY-HGE----K-----------GQSPSDVI---LEGSDQH Cj1061c VYDILDVWFDSGSTFNAVLNSG-LYD----A-----------GEKRASMY---LEGSDQH MG345 EIDTLDVWFDSGSSYNVLEI---NK-----------------YGSIADLY---IEGSDQY MPN520 ETDTLEVWFDSGSTYNVLIS---NK-----------------LNFPADLY---LEGSDQY UU410 EKDIMDVWFDSGSSYNILGH---YN-----------------LNYPADVY---LEGYDQY PH1065 VKDVVDVWFDSGIASWASLGYPRNKEL-FEK------------LWPADFI---VEGEDQV PAB0616 VKDVVDVWFDSGIASWASLGYPRNKEL-FEK------------LWPADFI---VEGEDQV MTH1375 TPDVLDVWIDSGVAGWAALHYPSETEL-FRE------------WFPYDFI---TEGHDQT MJ0947 VPDVLDVWFDSGLAPYASIG--------VKE------------LKKADFI---TEGHDQV AF0633 VPDVFDVWFDSGVASWGSIAYPLRKDK-FEE------------LWPADFI---TEGHDQT APE0374 VPDVLDVWFDSGIAFYASLGYPRDRET-WER------------LKPVDFI---VEGHDQI Ta0879 EPYVIDTWFDSGSATYAASHYPFEKNFDPET------------DVPVSFI---TEAIDQT TVN0829 EPYVIDTWFDSGSATYAAMHYPFEDNFDPSS------------DLPVSFI---TEAIDQT CT019 IPYVFDCWFDSGAMPYAQNHYPFERAEETEA------------CFPADFI---AEGLDQT CPn0109 IPYVFDCWFDSGAMPYAQNHYPFENQKETEE------------AFPADFI---AEGLDQT TP0452 VPEVLDCWFESGAMPYAQQHYPFEHATDFER------------YFPAHFI---SEGLDQT BB0833 TSEVLDCWFESGAMPYASNHYPFTNEINFKN------------IFPADFI---AEGLDQT Rv1536 IPDVLDVWFDSGSMPYAQVHYPFENLDWFQG------------HYPGDFI---VEYIGQT ML1195 IPDVFDVWFDSGSMPYAQVHYPFENDDWFDGFDSADSDKQVDAHYPGDFI---VEYIGQA RP617 IDDVFDCWFESGSMPYGQVHYPFENKKWFVE------------HFPADFI---VEYSSQT YBL076c IEEVFDCWFESGSMPYASQHYPFENTEKFDE------------RVPANFI---SEGLDQT VNG2190G VPDVFDVWLDSSVASWGTLNYP-EQEDDFDE------------LWPADLI---MEAHDQT DR1335 VPEVLDVWFDSGSMPYAQWGLLLNEQGEAVRG-----AEQFAKHYPADYI---CEAIDQT YPL040c SQDTMDVWFDSGSS-WSVIKDFYEKSLKLS-------------KLPSPLYQVCLEGSDQH .: *::*. * .* mlr8250 RGWFHSSLLESCGTRG--RAPYDTVVTHGFTMDEDGRKMSKSLGNTVVPQDVIK------ CC0701 RGWFQSSLLEGCGTRG--RAPYKAVVTHGFTMDENGEKMSKSRGNTIEPQTITK------ ileS RGWFMSSLMISTAMKG--KAPYRQVLTHGFTVDGQGRKMSKSIGNTVSPQDVMN------ ZileS RGWFMSSLMISTAMKG--KAPYRQVLTHGFTVDGQGRKMSKSIGNTVSPQDVMN------ VC0682 RGWFQSSLISSVAMKG--KAPYKEVLTHGFVVDGQGRKMSKSIGNVVAPQDVTN------ HI0962 RGWFMSSLMLSTATDS--KAPYKQVLTHGFTVDGQGRKMSKSIGNIVTPQEVMD------ PM1662 RGWFMSSLMLSTATDN--KAPYKQVLTHGFTVDGQGRKMSKSIGNIVTPQEVMD------ PA4560 RGWFHSSLLTGCAIDN--HAPYRQLLTHGFTVDESGRKMSKSLGNTVVPQTVID------ NMB1833 RGWFQSSMLTGCASSMG-RAPYKQLLTHGFVVDGEGKKMSKSIGNVVAPQEVYN------ NMA0622 RGWFQSSMLTGCASSMG-RAPYKQLLTHGFVVDQNGRKMSKSIGNVVAPQEVYN------ XF2418 RGWFQSSLLTGVAMDN--AAPYKQCLTHGFTVDQHGRKMSKSLGNGIEPQDIIK------ BU149 RGWFMSSLIISTLISE--KKPYSEVLTHGFVVDGKGQKMSKSIGNTISPNEIVD------ BS_ileS RGWFNSSLSTAVAVTG--KAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMK------ BH2545 RGWFNSSLSTSVAITG--KAPYKGVLSHGFTLDGEGKKMSKSLGNVVIPNDVMK------ L0350 RGWFNSSITTSVAVNG--VAPYKAVLSQGFVLDGKGRKMSKSIGNTIVPKDVTK------ SPy1513 RGWFNSSLITSVAVNG--HAPYKAILSQGFVLDGKGEKMSKSKGNIISPNDVAK------ sll1362 RGWFQSSLLTSVAVNG--IAPYKTVLTHGFVLDEKGHKMSKSLGNVVDPYQIINGGKNQK aq_305 RGWFQASLLESVGSYL--EAPYKAVLTHGFIVDEKGRKMSKSLGNVISPQEVVK------ TM1361 RGWFHSSIFLAVAKRG--SAPYKEVLTHGFIKDEQGRKMSKSLGNVVDPMEVVE------ jhp1317 RGWFQSSLLIGCVLNN--QAPFKKVITHGFIVDEKGEKMSKSKGNVVSLDNLLK------ HP1422 RGWFQSSLLIGCVLNN--QAPFKKVITHGFIVDEKGEKMSKSKGNVVSLDKLLK------ Cj1061c RGWFQSSLLVGTAINE--SAPYESILTHGFTTDEKGQKMSKSKGNVIASEYVAK------ MG345 RGWFNSSSNCGIIQND--LIPFKSLVSHGFTLDENGNKMSKSLGNIVDPLKICD------ MPN520 RGWFNSSASCGIIQTD--QLPFKSLISHGFTLDEHGNKMSKSLGNVVDPLKLCD------ UU410 RGWFNSSLITGTILNN--RAPYKYLVAHGMVLDGEGYKMSKSKGNVVDPLDVCK------ PH1065 TKWFYSQQAASVIAFD--TVPYRRVAMHGYVLDEKGDKMSKSLGNIIRPEEVVE------ PAB0616 TKWFYSQQAASIVAFD--TVPYRRVAMHGYVLDEKGDKMSKSLGNIIRPEEVVE------ MTH1375 RGWFYSQLGCGVIALD--EVPYRRVLMHGFTLDEEGRKMSKSLGNVVEPEDVIE------ MJ0947 TKWFYSQHALSAIVFN--DIPYKKCLMHGFTLDEHGDKMSKSLGNVVNPDDVVE------ AF0633 RGWFYSQLGTSVVCFD--KAPYKAVLMHGFTLDEQGRKMSKSLGNVVEPEEVVG------ APE0374 RGWFFSLLRSGVIGFG--ETPYRRVLVHGFALDEQGREMHKSLGNYVDFEELIA------ Ta0879 RGWFYVLHVIATIMFN--KNAYESALSINFILDAQGRKMSKSKGNSVYALDFLN------ TVN0829 RGWFYVLHVISTIMFN--KNAYDSALSISFILDEQGRKMSKSKGNSVFALDYLK------ CT019 RGWFYTLTVIAAALFD--QPAFKNVIVNGIILAEDGNKMSKRLNNYPSPKMIMD------ CPn0109 RGWFYTLTVISAILFD--RPAFRNAIVNGIILAEDGNKMSKRLNNYPSPKYVLD------ TP0452 RGWFYTLTILAVALFE--RPAFENCIVTGLVLASDGKKMSKALRNYADPNEVMD------ BB0833 RGWFYTLTILGTALFE--NTAFKNVIVNGLVLSSDGRKMSKSFKNYTDPMQVIN------ Rv1536 RGWFYTLHVLATALFD--RPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFD------ ML1195 RGWFYTLHVLATALFD--RPAFKTCIAHGVVLGSNGQKMSKSLRNYPDVTEIFD------ RP617 RGWFYTLMVLSTALFD--RPPFLNCICHGVILDATGQKLSKRLNNYADPLELFD------ YBL076c RGWFYTLAVLGTHLFG--SVPYKNVIVSGIVLAADGRKMSKSLKNYPDPSIVLN------ VNG2190G RGWFWSQLGMGTAALG--DVPYEEVLMHGYANMPDGRGMSKSKGITIEPNEVID------ DR1335 RGWFYSLHAISTMLYD--QPAYKNVICLGHIVDEKGLKMSKSKGNVVAPLPLFD------ YPL040c RGWFQSSLLTKVASSNVPVAPYEEVITHGFTLDENGLKMSKSVGNTISPEAIIRGDENLG ** .: . * : * mlr8250 ---QSGADILRLWVVTT--DYWEDQRLGKNV---LQTNIDAYRKLRN--TIRWMLGTLAH CC0701 ---ESGAEILRLWTAMV--DYQEDQRIGKTI---LATTTDAYRKLRN--TMRYLLGALAG ileS ---KLGADILRLWVAST--DYTGEMAVSDEI---LKRAADSYRRIRN--TARFLLANLNG ZileS ---KLGADILRLWVAST--DYTGEMAVSDEI---LKRAADSYRRIRN--TARFLLANLNG VC0682 ---KLGADILRLWVAST--DYTGEVAVSDEI---LKRSADAYRRIRN--TARFFLANLNG HI0962 ---KFGGDILRLWVAST--DYTGEMTVSDEI---LKRAADSYRRIRN--TARFLLANLNG PM1662 ---KFGGDILRLWVAST--DYTGEISVSDEI---LKRAADAYRRIRN--TARFLLANLNG PA4560 ---TLGADILRLWVAST--DYSGEIAVSQQI---LQRSADAYRRIRN--TTRFLLSNLNG NMB1833 ---EFGADILRLWAAST--DYSGELAISKEI---LKRVTESYRRIRN--TLSFLFANLSD NMA0622 ---EFGADILRLWAAST--DYSGELAISKEI---LKRVTESYRRIRN--TLSFLFANLSD XF2418 ---TLGADILRLWIAST--DYSNEMSLSQEI---LKRTTDAYRRIRN--TARFLLGNLHG BU149 ---TLGADILRLWVASS--NYSNDISISNEI---LKSSSDIYRRIRN--TARFMLANISD BS_ileS ---QLGADILRLWVSSV--DYQADVRVSDAI---LKQVAEVYRKIRN--TFRFLHGNLFD BH2545 ---QLGADILRLWVASV--DYQADVRVSDKI---LKQVSEVYRKIRN--TYRFLLGNLHD L0350 ---KFGADILRLWVASI--DTESDVRVSMDI---LSQVSEVYRKIRN--TLRFLIANTSD SPy1513 ---QYGADILRLWVASV--DTDNDVRVSMEI---LGQVSETYRKIRN--TLRFLIANTSD sll1362 QEPAYGADVLRLWVASV--DYANDVPIGQGI---LKQLVDIRNKIRN--TARFLLGNLHD aq_305 ---EFGADILRLWVVSE--DYTEDVKLGKNL---LKKIADDYRKIRN--TLRFIIGNLYD TM1361 ---KYGAEILRLWLASS--DYFNDIKISMRI---VEQQTEVYRKIRN--TFRFLLGNLED jhp1317 ---KHGSDVVRLWVAFN--DYQNDLRVSQTF---FIQTEQHYKKFRN--TLKFLLANFSD HP1422 ---THGSDVVRLWVAFN--DYQNDLRVSQTF---FTQTEQHYKKFRN--TLKFLLANFSD Cj1061c ---TYGVEILRLWILLS--DYSSDLKISDNI---LKQVGEQYRKIRN--TIRFLLANTN- MG345 ---QYGADILRLWVANT--DWQIDNKIGVNI---LKQVAEQYRRIRNS-LLRFILGNING MPN520 ---QYGADILRLWVTNV--DWQVDNRIGDNI---IKQIVEQYRRIRNS-LLRFILGNLNH UU410 ---IYGADVLRLWIANS--DYQNDTRISEEI---LKQNAEIYRRIRNT-LFKYSLSILND PH1065 ---KAGRDTFRFYMLWATNPWEN-LKFSWKG---VEQVRRMLNILWNVYVLSATYMSLDN PAB0616 ---RAGRDTFRFYMLWATNPWEN-LKFSWKG---VEQVRRMLNILWNVYVLASTYMSLDN MTH1375 ---KYGADVLRFYLLWENKPWED-LKFVWDE---LRNVNKMFNILWNVYVFATTYMSLDR MJ0947 ---KYGADLLRFYLLSANKVWED-LRFVWSE---MDDVLSLFNTLWNAYMFAVNYMVLDN AF0633 ---QIGVDGFRLYVLYS-APWED-LRFSWEE---ARNINRMLNVVWNAVRFAHTYMSLDN APE0374 ---KVPRDVVRFWVLQN-TVWED-LRFSWKG---LDLMRRDFNVIWNVYAFASIYMGLDR Ta0879 ---EVPPDSLRLFFLYGAPWKSK--NLDKKV--IDEVSRKTLMTVLNVYSFFAYNANIDN TVN0829 ---QVAPDSLRLFFLYGAPWKSK--NLDRKI--IDEVSRRVISTLLNVYSFFAYNANIDG CT019 ---AYGADALRLYLLNSVVVKAEDLRFSDKG--VESVLKQVLLPLSNALAFYKTYAELYG CPn0109 ---TYGADALRLYLLHSVVVKAEDLRFSDKG--IEGVLKQILLPLTNVLSFFNTYAELYG TP0452 ---RYGADALRLFLVRSAVVRADDLKYSDEG--VKDILKTVIIPLWNSYSFYVTYANIDG BB0833 ---TFGADALRLYLIMSPVVKADDLKYSDNG--VRDVLKNIIIPIWNAYSFFTTYAIIDK Rv1536 ---RDGSDAMRWFLMASPILRGGNLIVTEQG--IRDGVRQVLLPLWNTYSFLALYA---P ML1195 ---RDGSDAMRWFLMASPILRGGNLIITEPG--IREGMRQVLLPLWNAYSFLALYA---P RP617 ---KYGSDALRVTMLSSNVVKGQELLIDKDGKMVFDTLRLFIKPIWNAYHFFTIYANADS YBL076c ---KYGADALRLYLINSPVLKAESLKFKEEG--VKEVVSKVLLPWWN--SFKFLDGQIAL VNG2190G ---EYGADPMRMFLLSVT-PQGDDMSFSWDE---TENMQRDLNILWNVFRFPRPYMALDD DR1335 ---QYGADSVRWYMFMAS-DPGDQKRFSERL--VAEAQRSYVNTLWNVYSFFVLYANLDQ YPL040c -LPALGVDGLRYLIAQS--NFTTDIVAGPTV---MKHVGEALKKVRL--TFRYLLSNLQK : .* mlr8250 DDGE---------------TVPLE--AMPELERLMLHRLAELDEVVR-QGYDAFEFKRIT CC0701 FDEEE-------------RVTDYD--QFPALEKYILHRLWELDGQVR-EAYQSYRFSDVI ileS FDPAK-------------DMVKPE--EMVVLDRWAVGCAKAAQEDIL-KAYEAYDFHEVV ZileS FDPAK-------------DMVKPE--EMVVLDRWAVGCAKAAQEDIL-KAYEAYDFHEVV VC0682 FNPTT-------------DIIPVE--DMVALDRWAVGRALAAQQEII-QAYQDYNLHAVV HI0962 FDPKR-------------DLVKPE--KMISLDRWAVACALDAQNEIK-DAYDNYQFHTVV PM1662 FDPKR-------------DLVKPE--EMMVLDRWAVDCAYQAQNEIK-DAYDNYQFHAVI PA4560 FDPAT-------------DLLPPQ--EMLALDRWAVDRALLLQREIE-EAYREYRFWNVY NMB1833 FNPIE-------------DAVQQA--DMVEIDRYAVVLARQLQECLAGDYYPRYAFHFAV NMA0622 FNPIE-------------DAVQQA--DMVEIDRYALVLARRLQERVAGDFYPRYAFHFAV XF2418 FDPTL-------------HLVPLS--DMIALDRWIVHRAFELQQTIK-AAYTRYDFAEIV BU149 FDPKK-------------NIISKE--NMVLLDKWAIGQTKIVQEEII-QHYNNYNFHAVI BS_ileS FDPKT-------------NAVAVE--DLREVDQYMLIKLNKLIDKVK-KAYDEYEFAVVY BH2545 FHPAT-------------HRVAID--QLNGLDRYMLAKLNDVINRVK-KAYDEYQFSTVY L0350 FNPKE-------------DAIDFA--ELRPVDKYMLVKFNELVKQIR-TAYDNYSFMTVY SPy1513 FNPAT-------------DTVAYA--DLGTVDKYMTIVFNQLVATIT-DAYERYDFMAIY sll1362 FNPET-------------DAVAYE--DLPELDRYMLHRMTEVFTEVT-EAYESFQFFKFF aq_305 FNPRT-------------NALPFE--KLHHFDRWIISELQNLLKKVH-ENYEKFLFYRVH TM1361 FDPEL-------------DRVPHE--KLLTIDRWALGRLQEIIKRAT-EYYDSYEFSKVY jhp1317 MDLKN-------------LERPH---DFSPLDHFILEALETISAGVN-SAFEEHDLVKGL HP1422 MDLKN-------------LERPH---NFSPLDHFMLETLETISAGVN-SAFEEHDFVKGL Cj1061c -DLKD-------------LEVK----EFSFIDKWILSRATKVFKASK-EAFFAYEFAKGF MG345 FNFT---------------SMDDY--KFSLEDKIVIHKTNSLVEQIE-KFLEKYNFLGCL MPN520 FNFG---------------EMKDY--RFALEDKIVIHKTNALVQELH-QWLKQYNFLNCL UU410 FEPS---------------VDFSF--NVRQEEQFVLNEFNELHIKVI-KAYENFDYQTVV PH1065 FDPR-------------NVKVEELA--FREEDKWILSRVNSLIREVE-NGIETFYLTKAT PAB0616 FDPR-------------KLNPDELP--FREEDKWILSRVNSLISEVE-NGIESFYLTKAT MTH1375 FQPG-------------DHSAEDLS--FRDEDRWILSRINSVALKVT-EAIENLHFHRAT MJ0947 FKPD-------------EKYFEYL----KDEDRWIVSRINSVAKIAI-ENLEVPYFHTYT AF0633 YSFG-------------EKGELKI------EDRWILSRLESFIKEAN-EAMEGYQVHRVV APE0374 FDPR-------------RTSLSSVEDSLEVEDRWILSRLASLKRRYL-TAMEDLRIHDAA Ta0879 FQWNG-------------LQLSGN-----ALDRYMVSKVNSFVRSSR-DAYESLDFHEVV TVN0829 FEFKG-------------ILEAKD-----TLDKWLISKINTFIIESR-RAYDDLDFHEVV CT019 FDPKETDN----------IELA-------EIDRWILSSLYSLVGKTR-ESMSQYDLHAAV CPn0109 FDPKSQD-----------IEPAYT-----EIDQWILSNLYSVVGKVR-ESMSQYHLNFAV TP0452 IDPPVCAKVDGMGQAVTRLATHLNN----PLDRWILSLTEKLVQDIA-CALDAYDVSKVA BB0833 FKPP------------KNLSLAKNN----NLDKWIISELESLKKILN-TEIDKYNLTKSI Rv1536 KVGT--------------WRVDSVH----VLDRYILAKLAVLRDDLS-ESMEVYDIPGAC ML1195 KIGT--------------WHTDVSH----VLDRYILAKLAVLRDDLS-QAMEVCDISGAC RP617 LKGT--------------LNFASQN----VLDVYILSKLKIAVNKIE-ESLDNFDTQTAY YBL076c LKKMSN----------IDFQYDDSVKSDNVMDRWILASMQSLVQFIH-EEMGQYKLYTVV VNG2190G FDANVPAAFGG-----DDAGVGIADADLETVDEWLLSRLQHVKADAT-AHWEDFEQHRAL DR1335 PDLAA------------APAVAER----PEMDRWLLARLEETVRDVT-AALESYDARSGG YPL040c SQDFN--------------LLPIE--QLRRVDQYTLYKINELLETTR-EHYQKYNFSKVL : mlr8250 RALVDFMVVELSAFYFDIRKDALYCDAPSSVKRKASVQVVRHLFDCLVKWLAPMLPFTME CC0701 RPLIEFCQGDLSALYFDVRRDSLYCDRPDALKRRAYRTALDYVFDRLTIWLAPLASFTME ileS QRLMRFCSVEMGSFYLDIIKDRQYTAKADSVARRSCQTALYHIAEALVRWMAPILSFTAD ZileS QRLMRFCSVEMGSFYLDIIKDRQYTAKADSVARRSCQTALYHIAEALVRWMAPILSFTAD VC0682 QRLMNFCSIEMGSFYLDVIKDRQYTAKRGGHAQRSCQTALFFIVEALVRWMAPIMSFTAD HI0962 QRLMRFCSVEMGSFYLDIIKDRQYTTKADSLARRSCQTALWHIAEALVRWMAPILSFTAD PM1662 QRLMKFCSIEMGSFYLDIIKDRQYTTKADSLARRSCQTALWHIAEALVRWIAPVLSFTAD PA4560 SKVHNFCVQELGGFYLDIIKDRQYTTGANSVARRSCQTALFHIAEALVRWIAPILAFTAE NMB1833 KDIVSFCSEDLGAFYLDILKDRLYTTKADSHARRSAQTALYHITRSLVLLIAPILCFTGE NMA0622 KEMVSFCSEDLGAFYLDILKDRLYTTKADSRARRSAQTALYHITRSLVLLIAPILCFTGE XF2418 QTILNFCSVDLGSLYLDVTKDRLYTMREDAPGRRSAQTAMYHLTAAFVRWIAPILSFTAD BU149 QRLMYFCSIEMGSFYLDIIKDRQYTLKKHSQERRSSQTAIYYIINSLVRWIAPILSFTAD BS_ileS HSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSMQTVSYETLLALVKLSAPILPHTAD BH2545 HELHNFCTIELSSFYMDIAKDTLYVKHADHPDRRATQTVMYDVLVALAKLLSPIIPHTAD L0350 KSIINFITNDLSSFYLDFAKDVVYIEAANSPERRSMQTVMYVILKDLVKILVPILPHTAE SPy1513 KAVVNFVTVDLSAFYLDFAKDVVYIEAANSLERRRMQTVFYDILVKITKLLTPILPHTTE sll1362 QTVQNFCVVDLSNFYLDIAKDRLYISAPNAPRRRSCQTILQLALENLTKAIAPVLCHLAE aq_305 NHIKNFVITTLSAIYLDVLKDRLYVYAPASWERRSAQTALWHLLIALTTSTAPYLSFTAE TM1361 NLVVKYCTTELSSLYLDVVKDRLYVEAKDSIYRRSAQTVMHEILISLMKILAPIMTFTME jhp1317 NILMAFVTNELSGIYLDACKDSLYCDSKNNEKRQAIQMVLLAVASQLCYFLAPILTHTIE HP1422 NILMAFVTNELSGIYLDACKDSLYCDSKNNEKRQAIQMVLLATASKLCYFLAPILTHTIE Cj1061c SLLLNFLSADLSGIYLDISKDRLYCDSENAQRRKSAQVAMALMAKELLNLLAPNLSYSVD MG345 KVINKFV-LWLSSWYFEIIKDTLYCDAKNNPNRLAKQAVLNYIFTQLISFLNIFIPHTAE MPN520 KAINKFV-LWLSGWYFEIIKDTLYCDAKTNPNRVAKQAVLNYIFTQLIGFLNIFIPHTAE UU410 KLFNKFI-LDLSSWYFENIKDDMYCLAINDPIRKQIQSAVYWILKNSLIDLTPIIPHTTE PH1065 RALYNFVVEDLSRWYVRLIRKRLWVEGDDP-DKLAAYYTLWKVFDVLLRLMAPFTPYITE PAB0616 RALYNFVVEDLSRWYVRLIRKRLWVEGEDP-DKLAAYYTLWKVFDVLLRLLAPFTPYIAE MTH1375 REIHDFIVEDLSRWYIRLIRSRTWIERDDP-DKLAAYHTLYTVLKTLIVTLSPMAPHVCE MJ0947 WTLKDFILNDLSRWYIRLIRDRTWKEKDDA-DKLAAYQTLYYVLLKLATILAPVAPHTAE AF0633 RAFFDFFVEDFSRWYIQIIRPRVWEERDSP-SKLAAYYTMFRVIDRSLRAIAPFAPLIAE APE0374 RALRSFIIEDVSHWYLRIIRRRVWEEVDTP-SKRAAYATLYKVLWEWLLMAAPLIPYTAE Ta0879 RASMEF-VDDLSNFYLRLSRRRFWAEGFDD-DKLSAYSTLYYALKAFSEVMAPITPFFSD TVN0829 RLSMDF-VDNLSNFYLRLSRRRFWAEDVTE-DKLAAYSTLYTAIMTCSKVLAPIVPFVSD CT019 NPFVDF-IEDLTNWYIRRSRRRFWDAEDSA-DRRAAFSTLYEVLVVFSKVIAPFIPFIAE CPn0109 EPFVTF-IDDLTNWYIRRCRRRFWEAEDTP-DRRAAFSTLYEVLTVFCKVIAPFVPFLAE TP0452 DPIVSY-VDQLNNWYIRRSRRRFWKSINDE-DKRCAYNTLYCVLKRCVLAIAPVVPFITE BB0833 ESLLEF-IDKLNNWYIRRSRRRFWKSENDK-DKNDAYETLYYAIKTLMILLAPFIPFITE Rv1536 EHLRQF-TEALTNWYVRRSRSRFWAEDAD------AIDTLHTVLEVTTRLAAPLLPLITE ML1195 EQLRQF-TEPLTNWYLRRSRARFWDEDVD------AIDTLHTVLEVTARLAAPLLPLITE RP617 HAVSEF-FEVLNNWYIRRSRARFWKNEKDT-DKQNAYNTLYSCLKIMTIAMSALIPMISE YBL076c PKLLNF-IDELTNWYIRFNRRRLKGENGVE-DCLKALNSLFDALFTFVRAMAPFTPFLSE VNG2190G DAVLEFVVEDLSRYYVQVVRERMWEDDASA-SKTAAYATMQRVLLEVVALLAPYAPFVTE DR1335 RALEGF-VDDLSNWYVRRSRSRFWGEGGT--VDTAAYATLHEALLVVSQLTAPFTPFLAD YPL040c ITLQYHLNNELSAFYFDISKDILYSNQISSLARRQVQTTLVHILNAYRAILAPILPVMVQ . . *. : : mlr8250 EAWLDRHP--------------------------DAVSVHLDQF-----PEIPADWKNEA CC0701 EAWTTRFP--------------------------EAGPVAYRVM-----PERVDAWRNDA ileS EVWGYLPGE-------------------------REKYVFTGEW-----YEGLFGLADSE ZileS EVWGYLPGE-------------------------REKYVFTGEW-----YEGLFGLADSE VC0682 EIWNAMPAQQA-------------------DGSARDKFVFTTEW-----FDGLFGLAEGE HI0962 EIWQHLPQTE----------------------SARAEFVFTEEF-----YQGLFGLGEDE PM1662 EIWQYIP-------------------------GERGEFVFTEEF-----YNGLFALDANE PA4560 EVWKFLPGE-------------------------RAESVMLATW-----YDGLNELPADV NMB1833 EAWDIIGGG-------------------------EEDSVLFHTW-----HEFPTINEKTE NMA0622 EAWDIIGGG-------------------------AEDSVLFHTW-----HEFPTINEKAE XF2418 ELWSYLPGD-------------------------HADNVLFTTW-----YDGLAPLPPNA BU149 EIWSYLPEN-------------------------NSQYVFMEEW-----FDKLFYLDQDD BS_ileS ELWSHLTFVEE-------------------QS------VQLTDM-----PETITVPNSE- BH2545 EVWKHIPGVEE-------------------ES------VQLTDM-----PEPIELGDVS- L0350 ETWTYLEHEPE-------------------NF------AYLAEM-----PEAAEIPGSE- SPy1513 EIWSYLEHESE-------------------AF------VQLAEM-----PVAETFSAQE- sll1362 DIWQFLPYEKP-------------------TE------SVFQSG-----WVNLDAQWQQP aq_305 ELWEHVGKLDP-------------------SLP---ESVFLYEM-----PKPDENLKDE- TM1361 EVYSHLHEKDR-------------------KY----KTVQAEYW-----PEYREEFIDR- jhp1317 EVLEHSQVLR---------------------AFLQAKDVFDLKG-----ISVLEKLHLKE HP1422 EVLEHSQALR---------------------IFLQAKDVFDLKD-----ISVSEKLHLKE Cj1061c EALEHANVL----------------------IKGDAKDVFDL--------SLTQDFDY-D MG345 DAWKNYSFNK------------------------KPISVNLFTK-----PTVFKVANSK- MPN520 DAWQNYLLPK------------------------KPVSVNLFAG-----PAMFKVANVK- UU410 EAYSFLKDAN------------------------KKESIRLEDF-----YDQSQFQFKK- PH1065 EIYQNLMR-----------------------PFIGIESVHMLDWPKVDESAVDEDLEKEM PAB0616 EIYQNLIR-----------------------PFTNVESVHMLDWPKVDEKAIDEELEREM MTH1375 DIYQNLVRG---------------------AEPDSPESIHMLDW-ILDEGAVDSQLEADM MJ0947 AIYQNLKT------------------------EDMEESIFMNKI-EVDEEFIDEELERDM AF0633 WFYQHVVK----------------------EFREGEESIFMEEYSTAEVEMIDGELEAAM APE0374 YLYIKVFRE---------------------AEERPEESIHMLDMPEPEDHLIDSTLEEDM Ta0879 FIYLNLGGD--------------------------KESVHLEAFPEFDSTLMDEKLESEM TVN0829 YLYLSLHGP--------------------------YESIHLDSFPEPDTSKIDHDLEKRM CT019 DMYQQLRGE------------------------TDPESVHLCDFPHVVLEKILPDLERKM CPn0109 DIYQKLKLE------------------------KEPESVHLCDFPQVEMDKILPDLEKRM TP0452 SIWQNIRAA------------------------DDVQSVHLADYPVCTPMVRDDALEFKM BB0833 EIYQNLKTD------------------------EDKQSIHLNDYPKANENFINKTIEEKI Rv1536 IIWRGLTR---------------------------ERSVHLTDWPAPDLLPSDADLVAAM ML1195 IIWRSVTG---------------------------GRSVHLTDWPQANQLPADPDLVAVM RP617 TIYQGLHNTAITQLNCLLSEGKHIVQNPMSDTQDYNTSVHLCNYPTLSDFEINYELVSTM YBL076c SIYLRLKEYIP--------------EAVLAKYGKDGRSVHFLSYPVVKKEYFDEAIETAV VNG2190G ELYSHLTGD------------------------RGYDTVHMADWPTVEESLRAPALEADV DR1335 ALYRNLSGE--------------------------ESSVHLTPWPTVRAERLDRKLTADM YPL040c EVWKYIPEG----------------------------WLQGQE------HIDINPMRGKW mlr8250 --LAEKWRKVRQVRRVVTGALEIARAQK-VIG------SSLEAVPVVTINDAALEA---- CC0701 --EAARWAKVEKVTSVVTGALEVERREK-RIG------SALEAAPVVHFADEDLLA---- ileS AMNDAFWDELLKVRGEVNKVIEQARADK-KVG------GSLEAA-VTLYAEPELSA---- ZileS AMNDAFWDELLKVRGEVNKVIEQARADK-KVG------GSLEAA-VTLYTEPELAA---- VC0682 ELNNAFWNDIQKVRGSVNKLLENARNEK-LIG------GSLQAE-LVLFADDSLAS---- HI0962 KLDDAYWQQLIKVRSEVNRVLEISRNNK-EIG------GGLEAE-VTVYANDEYRA---- PM1662 QMNDAYWQQVITLRNEVNRVLEQARNDK-IIG------AALEAE-LTIYANDTYAP---- PA4560 TLNRQYWEQVMAVKAAVNKELENQRAAK-AVG------GNLQAE-VTLYAEDALQA---- NMB1833 AELVKKWTAIREAREAVTAAIEPLRADK-TVG------SSLQAE-AEITAPEEMAG---- NMA0622 AELVKKWTAIREAREAVTAAIEPLRADK-TVG------SSLQAE-AEITAPEEMAG---- XF2418 PLTAADFDKLLTLRDHVTKVLEPMRANG-VIG------AALEAE-ITIAADADTAA---- BU149 LFNYQFWNEIITIKHEINKFLEEAIQNK-TIN------NSLETS-IILYVSHELSN---- BS_ileS -ATEEKFDRFMALRDDVLKALETARNEK-IIG------KSLEANLKLYP-NKENKE---- BH2545 -ELKQKWDAFINVRDDVLKALENARNEK-VIG------KSLTAAITLYA-DGDVRQ---- L0350 -ELLGNWQEFLDFRDKILKALESAREAK-LIG------KSLEATVTIYP-NEVVRT---- SPy1513 -DILEAWSAFMTLRTQAQKALEEARNAK-IIG------KSLEAHLTIYA-SEEVKT---- sll1362 -QLAQKWVSLRQLRDGINQLLEQARRDK-VIG------SSLEAKLIIVD-PRTAESGTDE aq_305 -EVLKDYEILLKVRDEVMRALEVARKEKGIIK------HPYEAKVYIRG-DESVES---- TM1361 -KLMEDFEKLLSIREDVLKALEEKRQQD-VIG------HSLDAEVVLVPKNDTIKA---- jhp1317 FKKPENFEAVLALRSAFNEELDRLKKEG-VVK------NSLECA--IEVKEKALCE---- HP1422 FKKPENFEAVLALRSAFNEELDRLKKEG-VIK------NSLECA--IEVKEKALDE---- Cj1061c FGIDDTF--LMSAREKFFEQIDILKKDK-IIK------STLELN--LNISFNKFPN---- MG345 -NLGNIYKTFTSIKNAAFKEIEKLRKEG-LIS------KNNQIE-LTVGINKKIPK---- MPN520 -GLDRLHESFSAIKDRAYAAIEQARQNG-VIT------KNNQVV-LTLGVDS-------- UU410 -GIAHV-KAFFSIKDQIFNELENARKNN-ILK------KNNEAF-VTIAKNLILDD---- PH1065 EFIRRIVEAGSAARQKARIKLRYPVRKIIIETQDETVKKAVERLNYILRDQLNAKEVVIG PAB0616 EFIRRIVEAGSAARQRAKIKLRYPVRRIIIETEDETVKKAVERLNRILRDQLNAKEVKVG MTH1375 DIVREIIEACARARDTARYKLRWPVREMVVVSEDEGVLKAAESLKNVIAEQANAKSIKTS MJ0947 AIVRDVVDAIYRGRDRIKYTLRYPLKEITIAGGEE-VKKAVERFEYIIKEQGNVKNIKFG AF0633 KVAKEIVEAAANARNKAKRKLRWPLRELVIESGSEKVRKAVEMLEETILSQCNVKQVRVV APE0374 EKARMVLEAILSARNEAGLKLRRPVRRVIIAASNPGVEGSLRRLEGLIRLMANAKEIEFA Ta0879 DRAYSVIETVRRLRQENSIKGRQPLREILIAG------DMEESIIDVVKSELNAKDIKLI TVN0829 DQAYSVIETVRRIRQEINIKGRQPVKEILLSG------NIDPEIIPVVSQEVNAKEIRIV CT019 QDIREIVALGHSLRKEHKLKVRQPLQNVYIVG-SKERKEALAQVGSLIGEELNVKDVHFC CPn0109 HDIREIVGLGHSLRKEHKLKVRQPLANFYVVG-SKDRLSLLKTFEGLIAEELNVKNVIFY TP0452 ETVQRVVSMARAIRAQCNLKVRQPLKAMQVITRNPMERSALLEMEEDVLDELNVKELVFH BB0833 NLARKITSMARSLRSLHNIKIRMPISTIYIVTKNQNEQNMLMEMQEIILDEINAKEMKIK Rv1536 DQVRDVCSAASSLRKAKKLRVRLPLPKLIVAV--ENP-QLLRPFVDLIGDELNVKQVELT ML1195 DQVRQVCSAASSLRKAKKLRVRLPLPKLVVAV--YNS-QRLKPYIDLIGDELNVKQIELT RP617 DNVLDICSNSLFIRSTENIRVRQPLACITIIS--KHN-NNLKDFEDLIKDEINVKTVIYR YBL076c SRMQSVIDLGRNIREKKTISLKTPLKTLVILHSDESYLKDVEALKNYIIEELNVRDVVIT VNG2190G AVLRAAEEAGSHARQQAGRKLRWPVTRVVVDAAEDSVVDALDAHGDLLADRLNTRAIEVV DR1335 AAVMKVVELGRAVRGAHNLKTRQPLAGVQVRAASPEALDALKRSQTQIMEELNVKAVTFL YPL040c PFLDSNTEIVTSFENFELKILKQFQEEFKRLS-------LEEGVTKTTHSHVTIFT---- mlr8250 ---------------AIADV-------------DMA---------EMAITSDLVIAHGQA CC0701 ---------------AFEGL-------------DAG---------EVFRTSSATLVAGDA ileS ---------------KLTALGD-----------ELR---------FVLLTSGATVADYND ZileS ---------------KLTALGD-----------ELR---------FVLLTSGATVADYND VC0682 ---------------KLAKLGD-----------ELR---------FVLLTSKAVVKPLAE HI0962 ---------------LLAQLGN-----------ELR---------FVLITSKVDVKSLSE PM1662 ---------------LLAKLQN-----------ELR---------FVLLTSKAEVKPLAD PA4560 ---------------QLAKLGN-----------ELR---------FVLITSTATLAPLSA NMB1833 ---------------YLNALGE-----------ELR---------FALLVSKAEVKVGSE NMA0622 ---------------YLNALGE-----------ELR---------FALLVSKAEVKVGSE XF2418 ---------------RWQPLTE-----------ELR---------FLFISGDVTVTPANT BU149 ---------------KLKILEQ-----------ETK---------FIFLTSDIQIKLYDT BS_ileS ---------------LLASIKEN-----------LS---------QLFIVSELTIS---- BH2545 ---------------LLEELGP------------LD---------KLFIVSAVKVAG--- L0350 ---------------LLTAIDEN-----------VA---------QLLIVSNFVVAN--- SPy1513 ---------------LLTALDSD-----------IA---------LLLIVSQLTIA---- sll1362 KQ---GENFVHWFYGWLENFNEPTF-DPNDRKISLR---------NIFLTSQVEFIKSAE aq_305 ---------------LLKKYEDY-----------LN---------FFFTVSQVELR---- TM1361 ---------------LLEKYRDI-----------LE---------ELFIVSKVSLS---- jhp1317 ------------------NL--------------VE---------ELLMVSFVG------ HP1422 ------------------NL--------------VE---------ELLMVSFVG------ Cj1061c ------------------EE--------------LA---------DWFMVSQISNEN--- MG345 ---------------KLKDN--------------LA---------LWLNVNSVNLTNN-- MPN520 -------------------------------------------------TSAIDPTS--- UU410 ---------------YLINNPKL-----------LA---------KWFGVAKIEFANN-- PH1065 -----KVERELTVKPNFAKVGPEFKGDSRLVAKWIN-EHG----LELYEKGEVDVEIEGK PAB0616 -----RVERELTIKPNFAKLGPEFKGDAKIIAKWIN-ENG----RELYEKGELTVEIDGK MTH1375 TE---FPDMKIIARPNPATLGPRLRQDIPLVMRELEGADGSAVKAALDSDGEFTVETDGK MJ0947 -E---VEGSKYIIKPNYRELGKRYRSEVPKVVEALNKADAK---ELMERLKEGAVILDG- AF0633 -D---SFEKEIEIKPNYKYIGPLLKEKAGEFAKYVASLKE-----IPEKLVFDGVELDP- APE0374 PASALEATRIYRVEPDYGRLGPKYKRDMPKVLRLIE-EKGGEIGRVLAEKGVYEGEYEGL Ta0879 ER--DQEPIRLSADLRMDRAAPVLRSRVNAVRHKIRSMDGLEV-QRQISEK-GFVEIDGV TVN0829 SS--EQRPLKYTVDLKMETAAPILRSSVNSVREALKSIDGKAA-FDAVQNG-GKLRVLDH CT019 SE--TPEYVTTLIKPNFRTLGKKVGNRLPEIQRALAGLPQEQI-QAFMHKGQMVVSLGEE CPn0109 EE--APSFIYTTVKPNFRMLGKKVGSKMKEVQKALSELPNNAI-DKLIQEETWVLTIDDR TP0452 EK--EDEIVEYRAKANFRVLGKELGSKTKRAALSIERLSSAEI-QEILEGTTLYLDVDGD BB0833 AN--EEELITYKAKANFKELGKKLGKDMKAVSTEISKLKNEDI-IKIINGTSYEIKVANA Rv1536 DA--IDTYGRFELTVNARVAGPRLGKDVQAAIKAVKAG-------DGVINPDGTLLAGPA ML1195 DA--IDTYGRFEFTVNARVAGPRLGRDVQAAIKVVKAG-------EGVANPDGTLTAGPV RP617 DD--LENYARKKLSLNFAILGKRLPHKMKAIIDAAKKG-------EWEATTLGLAICG-E YBL076c SDEAKYG-VEYKAVADWPVLGKKLKKDAKKVKDALPSVTSEQVR-EYLESGKLEVAGIEL VNG2190G EPGAAWDELAYSARADMSELGPAFGDDAGAVMNALNDARVTDR-DIDALAEQVAADLGRD DR1335 EG--DTDLVQYSLRPNLPVVGKQYGKQLPVLKKALTEADARAVATAVQAGQGFSVQADGV YPL040c -------------KHHLPFSSD-----------ELC---------DILQSSAVDILQMDD mlr8250 P---------------EGAFT----LDDVRG---VAVVVEKAEDRGLVKCARSWRYTADV CC0701 -----------------GAFR----VDEVKG---VSVDPNKAEGK---KCARSWRILPEV ileS AP--------------ADAQQ----SEVLKG---LKVALSKAEGE---KCPRCWHYTQDV ZileS AP--------------ADAQQ----SEVLKG---LKVALSKAEGE---KCPRCWHYTQDV VC0682 K---------------SEAAQ----ATDIDG---LFVQVNKTEAE---KCDRCWHHTPDV HI0962 KP--------------ADLAD----S-ELEG---IAVSVTRSNAE---KCPRCWHYSDEI PM1662 ----------------ADVAE----G-EVKG---FAVKVVRSANH---KCPRCWHYSDSK PA4560 AP--------------ADAVD----S-EVAG---LKLKVVKSTHA---KCGRCWHHREDV NMB1833 -----------------LAVA----A-------------KASDGE---KCERCWHYTRDV NMA0622 -----------------LAVA----A-------------KASDGE---KCERCWHYTRDV XF2418 -----------------DGFF----VS-----------AQPTTKA---KCARCWHYRADI BU149 AP--------------KNAKK----SKIVPY---LKVSLEKIKGK---KCPRCWHYFNFT BS_ileS ------------EEN-EAPND----AQSFAT---GKIAVEKAEGE---MCERSRVISKDV BH2545 ------------SVA-DAPKE----AESYDD---LAIVVEKAVGE---TCERCWVVSPTV L0350 -----------EPVN-NAPES----AMKFDD---LAVLVEHAAGE---VCDRCRRTDETV SPy1513 ------------DLA-DAPAD----AVAFEG---VAFIVEHAIGE---VCERSRRIDPTT sll1362 IEPSFTYEETVVINL-ERHDN----NIRTKP---IKIIVTKADGH---KCERCWNYSTQV aq_305 ------------EGG-EVQIE----GEELP----VKVGVNKAEGE---KCPRCWIYYQK- TM1361 ------------DAS--GELK----G-EL-----VEVTVKHAEGE---KCQRCWKYTTEI jhp1317 ------------------VAK----EKLSET---PAFTLFKAPFY---KCPRCWRFKSE- HP1422 ------------------IAK----EKLSET---PAFTLFKAPFY---KCPRCWRFKSE- Cj1061c ----------------EEILA----EFEVEN---EKFKITKASLC---KCPRCWKLQSK- MG345 ----------------ENEIK----V-------------KKTKKT---MCERCWNFQTII MPN520 -------------------------------------------------CK---TFSSLA UU410 ----------------TNVAN----A-------------NFKKCL---RCWNHFPDEEMY PH1065 KFHLTREHIIVEEKL-PDFLV----AEDFEG---GRVYVDKTLTRELLAEGLAREFVRRI PAB0616 TFHLTREHIIVEEKL-PDFFV----SEEFEG---GRVFVDKTLTRELIAEGLAREFVRRI MTH1375 KFKLTSEDIVFETEL-PENIV----SAQFDG---GSVFIDTELTPEIMSEAMARELVRRI MJ0947 -YEIKPEYVEIRLEI-PEHIA----GVEFSK---GTVFINTEITDDLIKEGLMREVIRRI AF0633 ----K-QAIVVDYRL-PEGYE----YAEFSG---GVVYIYKELDDELVREAFAREVIRRI APE0374 PVKLTLEDVSLKAEY-PEWLK----VRDTPL---GLVAVDTRLTKEEVLEGLARDIVRRI Ta0879 RLDPDMVEISRVPDP-NYAYS----QTEKYG---IDVFINKNIDRDGYLEGLARELVRRI TVN0829 ELTGEMLNISTIPDP-DYGYS----RDEKNG---IDVFVNKRIDRNEYLEGLAREIVRRI CT019 TISLDKEDITVSWAS-AEGFV----ARSSAS---FVAVLDCQLTEPLIMEGIARELVNKI CPn0109 EIALDGDDVVICRHT-DPGYI----ARSSAL---FSVILDCQLREPLIVEGIARELVNKI TP0452 RLELTEEKILVQRIE-RESLK----AINEGT---LTVALDTTLTEDLLLEGAIRDLVRGV BB0833 KHYLSLNDIILEREE-KENLK----VINEES---ITIGIDSLITKELYLEGLTREFVRQI Rv1536 VLTPDEYNSRLVAAD-PESTA----ALPDGA---GLVVLDGTVTAELEAEGWAKDRIREL ML1195 VLQPDEYSSRLVAAN-PEFTA----ELPDGS---GLVVLDDTVTPELEAEGWAKDRIREL RP617 ILNSDEYTLILEPYSHIKGTA----NFDNNS---SLLILNLELTSELIEEGYARDIVRFI YBL076c VKGDLNAIRGLPESAVQAGQE----TRTDQD---VLIIMDTNIYSELKSEGLARELVNRI VNG2190G DIELTTEMVEFVEET-PEHVAGAAFETETAA---GTVYVDTELNEDVESEGYAREVVRRV DR1335 TFDLTPGSVLVDAKA-PEGVA----AAEDAG---YLVAFDTALTPELVREGLARDLVRAI YPL040c N---------------NNSLP----TIELGSGINVQILVERSKRH---NCPRCWKANSA- mlr8250 G--QDPAFPDVSARDAAVLHE-----------LKALGRL--------------------- CC0701 G--TDPRYPELSLRDADAVAY-----------WDAGRG---------------------- ileS G--KVAEHAEICGRCVSNVAG-----------DGEKRKFA-------------------- ZileS G--KVAEHAEICGRCVSNVAG-----------DGEKRKFA-------------------- VC0682 G--TIAGHTTICGRCVSNVEG-----------EGEVRKFA-------------------- HI0962 G--VSPEHPTLCARCVENVVG-----------NGEVRYFA-------------------- PM1662 ------DAESLCSRCDENVNG-----------QGEVRQFA-------------------- PA4560 G--QHAAHPDLCGRCIENIEG-----------SGEVRHYA-------------------- NMB1833 G--AVAGYETVCKRCAENVGG-----------EGETRHYA-------------------- NMA0622 G--AVAGHETVCKRCAENVGG-----------EGETRHYA-------------------- XF2418 G--AHPTHPELCGRCVTNVDG-----------PGEQRHWF-------------------- BU149 K--KNIKNSDICNRCILNTIG-----------NGEKRIFI-------------------- BS_ileS G--ANPKYPTLSLRNAEIVEK-----------YYQK------------------------ BH2545 G--TNNEHPTLCADCAETVAT-----------YYVTK----------------------- L0350 GHNANEHLKMLCEHCAHIVET-----------EFPEILEEGFED---------------- SPy1513 --RMRSYNAFVCDHSAKIIEE-----------NFPEAVAEGFEESGK------------- sll1362 G--SFSDDPTICERCNEALQG-----------NF-------------------------- aq_305 ----EEFVGCVCKRCAKALSE-----------MGIELNAVC------------------- TM1361 S-ASEDFPG-VCPRCLAVLKG-----------ERK------------------------- jhp1317 ----LENTP--CKRCEEVLKE-----------R--------------------------- HP1422 ----LENTP--CKRCEQVLKE-----------R--------------------------- Cj1061c ----NEETP--CLRCEEVLKG-----------VQC------------------------- MG345 K--QKLD-HNLCSRCFKVC----------------------------------------- MPN520 K--RKPGKYNEWPQRN-------------------------------------------- UU410 N--DELS-MNCYKVINKIK----------------------------------------- PH1065 QEMRKRLDLDVNDRIVVTIETTDD----NRELLQENLDYIMRETRAIEVRFEEAKG---Y PAB0616 QEMRKRLDLDVNDRIIVTIETTDE----NVELLKENLDYIMRETRADKIVFGKAKG---Y MTH1375 QDMRKDLDLDVEASIEVSVKCSEE----FRELTEPQREFIENEVRASTLSFDYSELE--Y MJ0947 QAMRKDMDLDIEEKIKIKVEGID---------LDEFKEIIEREVRG--QFVDEIKAD--Y AF0633 QEMRKELDLDVEEFIETTVEMDA-------ELVKGWEDYIKSETRSQKLVFGKAEG---Y APE0374 QAMRKEAGYSVEDYVEVWIQGGED----VVEAVNALKEYIKRETRALKLEVGEPPSGVEV Ta0879 QVMRKEMNLNYTDRIITHLDLSDD----FLEALNKHAEYIKNETQSDSIITDKVE----G TVN0829 QLMRKEMNLDYTDRINVWIDPVGD----FSDAIDKFESYIKAETQCDSLNVGHTD----D CT019 NTMRRNRKLHVSDRIAIRLHAPVI----VQEAFALHKEYICEETLTTSVSVIDYK----E CPn0109 NTMRRNQQLHVSDRIALRIKTTEA----VHRAFLDYENYICEETLIIAYDFTQDSDF--Q TP0452 QNLRKERGFSLVDRICLRVFSSDQDIVCARKAYDLHRSYIVGETLAAHVQWARVRD---G BB0833 QNLRKEKNFDVSDRINLYIEN-NE--T-LKEMLNKFEKYIKTETLALNIILNKSK----- Rv1536 QELRKSTGLDVSDRIRVVMSVPAE----REDWARTHRDLIAGEIL---ATDFEFA----D ML1195 QELRKLIGLDVSDRIRVLMSVPAE----RADWARVHRDFIAREIL---ATSFEFG----E RP617 QYARKEADFSITDRILIEIISEFD----LSKIIDHYGDFIKEQTLGEFAKNFTP-----D YBL076c QKLRKKCGLEATDDVLVEYELVKDT-IDFEAIVKEHFDMLSKTCRSDIAKYDGSKTDPIG VNG2190G QEMRKEMDLAMDAEIRLDVLVFDER---VGELVARHEPLITAETRARELGEVEDG----H DR1335 QEARKAAGFEVQDRIALALELDG----EALEAAQAWQDFIAGEVLAEQVAYGSGE----- YPL040c -----EEDK-LCDRCKEAVDH-----------LMS------------------------- mlr8250 --------------------------- CC0701 --------------------------- ileS --------------------------- ZileS --------------------------- VC0682 --------------------------- HI0962 --------------------------- PM1662 --------------------------- PA4560 --------------------------- NMB1833 --------------------------- NMA0622 --------------------------- XF2418 --------------------------- BU149 --------------------------- BS_ileS --------------------------- BH2545 --------------------------- L0350 --------------------------- SPy1513 --------------------------- sll1362 --------------------------- aq_305 --------------------------- TM1361 --------------------------- jhp1317 --------------------------- HP1422 --------------------------- Cj1061c --------------------------- MG345 --------------------------- MPN520 --------------------------- UU410 --------------------------- PH1065 VVEWPEVQA-------KIGIEKVE--- PAB0616 VVEWPEVQA-------KIGIEKVEE-- MTH1375 TKEWKISDE-------NLIISIKPAKV MJ0947 EKDWEIKTPNGEKYNVKIAIERINK-- AF0633 VREWNIEGKK-----VKIGIKRLRG-- APE0374 LREWELDGEK-----VVIALKRAAASG Ta0879 MKLWEINGEP-----VRIKIDLAR--- TVN0829 LRKWEIGDET-----IGIRIEKVVPK- CT019 GEEWDINGHA-----VSFVLERVER-- CPn0109 GENWDINGHATQ---IEITVSSIDS-- TP0452 ASAVYVKSDAVL---WEVSIDKA---- BB0833 LEKKINLADDIF---TLIGIEKC---- Rv1536 LADGVAIGDG-----VRVSIEKT---- ML1195 PADSVAIGDG-----VRVSLLKV---- RP617 YVSKVALENNQ----IQLKVKRL---- YBL076c DEEQSINDT-----IFKLKVFKL---- VNG2190G REEWDVEGTT-----MILEVEAV---- DR1335 GFRAEVEGG-------AVTLKKL---- YPL040c ---------------------------