CLUSTAL W (1.74) multiple sequence alignment yciO ----------------------------------------------MGTAAEHHREGIMS ZyciO ----------------------------------------------MGTAAEHHREGIMS VC1178 ----------------------------------------------------------MS HI1198 ----------------------------------------------------------MS PM0662 ----------------------------------------------------------MS NMB0436 ---------------------------------------------------MTIRKQTMA NMA2049 ----------------------------------------------------------MA PA3199 ----------------------------------------------------------MS yrdC ------------------------------------------------------------ ZyrdC ------------------------------------------------------------ HI0656 ------------------------------------------------------------ PM1270 ------------------------------------------------------------ VC0054 ------------------------------------------------------------ BU494 ------------------------------------------------------------ PA0022 ------------------------------------------------------------ XF0919 ------------------------------------------------------------ NMB2150 ------------------------------------------------------------ NMA0237 ----------------------------------------------------MTDVLQTV BS_ywlC -----------------------------------------------------MKTKRWF BH3771 --------------------------------------------------MSYKQTNHWI PH0435 ----------------------------------------------------------MT PAB1302 ----------------------------------------------------------MT mlr7439 ----------------------------------------------------MTRVAEIL CC3390 ----------------------------------------------------MGFDGRDR Ta0302 ----------------------------------------------------MTR----I TVN1298 ----------------------------------------------------MTR----V TM0852 ----------------------------------------------------MTR----V APE2397 -----------------------------------------------MSLASMGKGSCEI Rv1301 -------------------------------------------------------MTETF ML1136 ----------------------------------------------------MVRMNEVF L189883 MKFVQGGLNNFANELEKVEGGFYGIIGLLFRRPYKVPDDLKNIRENLFIEAKTLQKELDK SPy1143 ------------------------------------------------------------ BBT06 ------------------------------------------------------------ BBU11 ------------------------------------------------------------ BB0734 ------------------------------------------------------------ MG259_2 ------------------------------------------------------------ MPN362_2 ------------------------------------------------------------ YGL169w ---------------------------------MYLGRHFLAMTSKALFDTKILKVNPLS sll0216 ----------------------------------------------------------MA RP848 ------------------------------------------------------------ VC1079 ----------------------------------------------------MPNHGDFL AF0781 ------------------------------------------------------------ VNG2312C ------------------------------------------------------------ MTH1692 -----------------------------------------------------------M aq_651 ------------------------------------------------------------ MJ0062 -----------------------------------------------------MGLKNKI UU005m ------------------------------------------------------------ CT137 ------------------------------------------------------------ CPn0270 ------------------------------------------------------------ DR1862 -------------------------------------------------------MTDFA sll1866 ------------------------------------------------------------ TP0182 ----------------------------MRTCIPLILGMHVRLLHLHVLATRVARCTRCA slr0006 ------------------------------------------------------MVTLDK yciO QFFYIHPDNP-----------QQRLINQAVEIVRKGGVIVYPTDSGYALGCKIEDKNAME ZyciO QFFYIHPDNP-----------QQRLINQAVEIVRKGGVIVYPTDSGYALGCKIEDKNAME VC1178 QFFYVHPENP-----------QTRLINQAVAIIRNGGVVVYPTDSGYALGCQLENKHGME HI1198 QFFYIHPENP-----------QARLINQAVEILQKGGVIVYPTDSGYALGCMMGDKHAMD PM0662 QFFYIHPENP-----------QVRLINQAVEILRAGGVIVYPTDSGYALGCMIGDKHAMD NMB0436 QFFAIHPDNP-----------QERLIKQAVEIVNKGGVVVYPTDSCYALGCKLGDKAAME NMA2049 QFFAIHPDNP-----------QERLIKQAVEIVNKGGVVVYPTDSCYALGCKLGDKAAME PA3199 QFFQIHPENP-----------QPRLVKQAVEIVRQGGVIVYPTDSSYALGCRIGEKTAVD yrdC -----MNNNL-----------QRDAIAAAIDVLNEERVIAYPTEAVFGVGCDPDSETAVM ZyrdC -----MNNNL-----------QGDAIAAAIDVLNEERVIAYPTEAVFGVGCDPDSETAVM HI0656 -----MN------------------REQIADALRQNQVVAYPTEAVFGLGCNPQSESAVK PM1270 -----MN------------------IQQIVEQLKQNEVVAYPTEAVFGLGCNPNSESAVQ VC0054 -----MALVE-----------N---LQQAVDALRKGCVIAYPTEGVFGLGCDPDNQTAML BU494 -------------------------------MLHNDDVIAYPTESMFGLGCDPNSKKAVK PA0022 -----MISSF-----------R---AQCAARVVREGGVIAYPTEAVWGLGCDPWNEDAVY XF0919 -----MATTL-----------T---LSEAVTALQQGGVIAYPTEAVWGLGCDPRQETAVH NMB2150 ---MLFPRII-----------AASAQRKLSVYLKKGGLVAYPTESCYGLGCLPTLAKALG NMA0237 FYIMLFPRII-----------AASAQRKLSVYLKKGGLVAYPTESCYGLGCLPTLAKALG BS_ywlC VDVTDELSTN-----------D-PQIAQAAALLRENEVVAFPTETVYGLGANAKNTDAVK BH3771 VDNNQHINKN-----------S-NEIKEAALWIKKGELVALPTETVYGLGANALSDEAVQ PH0435 IIINMRSGVD-----------E-VKLRIAAKLIREGKLVAFPTETVYGLGADALNERAVR PAB1302 IIINVRERIE-----------E-WKIRIAAGFIREGKLVAFPTETVYGLGANALDENAVK mlr7439 AVGEA---LE-----------R------ALALLGDGDVVAIPTETVYGLAGDATNGIGVA CC3390 GAGEGQLQAD-----------RQAEVAAAAEALRAGGLVILPTETVYGLGANAADPAAVA Ta0302 IHIDRSDYRR-----------D--QIVDAVDALRSGGTVVFPTETVYGLGALASNPEACK TVN1298 IHIDRNSYSK-----------D--DLYYAVEALKHGGTVVFPTETVYGLGANAMNDEACK TM0852 LKVDPLFPDE-----------K--VLKEAAELLRNGEVIIFPTETVYGIGADAYNEEACK APE2397 YRLDPERPDR-----------R--AIERAAEVLRRGGLVAFPTETVYGLGADALNPRAAA Rv1301 DCADPEQRSR-----------G---IVSAVGAIKAGQLVVMPTDTVYGIGADAFDSSAVA ML1136 DCADPDQRAR-----------G---IASAVAALKGGRLVVMPTDTVYGIGADAFDRAAVA L189883 QSEKENNNKN-----------R--LSARAIKALKSGQLAILPTETVYGLFADAMNEEAVQ SPy1143 --------ME-----------Y--LAS--I--IESGDALVLPTETVYGLFAKALDEKAVN BBT06 -MIKTPIISE-----------D--QFKIALKLIKMGEIIVFPTDTVYAIGANIYDEYAVR BBU11 -MIKTPIISE-----------D--QFKIALKLIKMGEIIVFPTDTVYAIGANIYDEYAVR BB0734 -MISTEIISS-----------S--QIQKAAKLIKMGELVVFPTETVYGIGANAYNEDAVK MG259_2 ---LPVVDIK-----------N---TKTIKQLLKMGLAGIVNTDTQMGLIS-----YSES MPN362_2 ------LKIA-----------Q---TKQIKALLDKGMTAIIPTDTQIGLMS-----YCQQ YGL169w IIFSPDAHIDGSLPTITDPETEAALVEAARIIRDTDETVAFPTETVYGLGGSALNDNSVL sll0216 TFYNLHPETP-----------QQRTVEMICKSLRQGAIMLYPTDTVYAIGCDLNDKNAVQ RP848 ------------------------MINKAVQFIKSGKVVVFPTETVYGIGADATNNEACL VC1079 LNTQQLSAMTP------------ADIECAAQLLKQGQLVAIPTETVYGLAADATQPEAVK AF0781 -MAEVLEPSR-----------E--GIRKAVAVLRAGGIVAFPTETVYGMGCDATNEEALR VNG2312C -----MSTDD--------------ALAEAAEALREGGLVVFPTETVYGLAADALDPDAIE MTH1692 LIRKITRKNP-----------SPDVLEEAISVMEGGGIVIYPTDTIYGLGVNALDEDAVR aq_651 ---MILKASK-------------EALKEAVEILKKGGIIVAPTDTLYGILADATNEEAVK MJ0062 IKIYELNEEE-----------RKKVLEFLKKEILNGKIVICGTDTLYGISANALNEKAVR UU005m --MKIYRITN---------------LNVIYDALMANKCVLIPTDTIIGLLAK----N-QD CT137 -----------------------MFSQQIEESIKAGQVFAFPTDTVYGLGVSFHILDADQ CPn0270 -MPDKKAQIT-------------FSLPEVMSAIHQGKIVALPTDTVYGFVLSLYASEAEE DR1862 ALPSPESLPSG--------FLPPELLRAAADVLDRGGVVAYPTETVWGLAAR---PAAAA sll1866 -----MPLVS---------------QSDLVSAAIAHRVVSFPTDTVPALAVR---PENSA TP0182 SASLSSCYSCCGVARVRILKHEAQSAHAAARALKAGALVALPTDTVYGFSG--LVPHAVP slr0006 TATKIIKLNSG-------------AIPAIQSVLEQEAMVLLGLATTYVLVVNGASPRAVA . yciO RICRIRQLPDGHNFTLMCRDLSELS---T-YSFVDNVAFRL---------MKNNTPGNYT ZyciO RICRIRQLPDGHNFTLMCRDLSELS---T-YSFVDNVAFRL---------MKNNTPGNYT VC1178 RICQIRRLDDKHNFTLLCRDLSELS---L-YARVDNTAFRL---------LKNNTPGPYT HI1198 RIVAIRKLPEGHNFTLVCSDLSELS---T-YARVNNTAYRL---------IKNNTPGRYT PM0662 RIVQIRQLPEGHNFTLVCSDLSELS---T-YSLVNNMAYRL---------IKNNTPGRYT NMB0436 RILSIRKIDLKHHLTLMCADLSELG---T-YAKVDNVQFRQ---------LKAATPGPYT NMA2049 RILSIRKIDLKHHLTLMCADLSELG---T-YAKIDNVQFRQ---------LKAATPGPYT PA3199 RIRRIRQLDDKHNFTLVCRDLSELG---V-YAKVDTGLFRL---------LKAHTPGPYT yrdC RLLELKQRPVDKGLILIAANYEQLKPYID-DTMLTDVQRET---------IFSRWPGPVT ZyrdC RLLELKQRPVDKGLILIAANYEQLKPYID-DTMLTDVQRET---------IFSRWPGPVT HI0656 KLLDLKQRPVEKGLILVAPSLDFFRPFVD-FEQINDEQLSR---------LQGKYERPTT PM1270 KLLVLKQRSVEKGLILVAPCLDYFLPFID-TTAFSQADWDR---------LQAKYDRPTT VC0054 RLLAIKQRPVEKGVILIAASYAQLRPYVD-ETQLTAEQLTQ---------VLASWPAPLT BU494 KLLNLKNRSIEKGLILVASDFDQIKMYVN-ENILSNKQKKK---------IFFHWPGPFT PA0022 RLLALKARPVEKGLIVVAANIHQLD--FL-LEDLPDVWLDR---------LAGTWPGPNT XF0919 TLLNIKQRASGKGLILVTAELNTLQDWLD-LDTLSPERLHE---------VQTSWPGPHT NMB2150 KLAHLKKRPQHKGMIVIGNQFEQLQP--L-LQMPSENLQDM---------LRKEWPAPKT NMA0237 KLAHLKKRPQHKGMIVIGNQFEQLQP--L-LQMPSENLQDM---------LRKEWPAPKT BS_ywlC KIYEAKGRPSDNPLIVHIADISQLEDLTG-PAPEKAKTL-----------MKRFWPGALT BH3771 KIFIAKGRPSDNPLIVHISRKEQLLRLVS-HIPDSANLL-----------INAFWPGPLT PH0435 RIFEAKGRPADNPLILHIAKFSQVYELAR-EVPEEAKVL-----------VERFWPGPLT PAB1302 RIFEAKGRPADNPLIIHIASFEQLEVLAK-EIPEEAEML-----------AKRFWPGPLT mlr7439 RIFEAKGRPRFNPLIAHVADMAMAERIA--VFDPLSKKL-----------AQAFWPGPLT CC3390 AIFEAKGRPRFNPLIAHVADLETAARIA--VFDDRAHAL-----------AREFWPGPLT Ta0302 KIFIAKGRPSDNPLIVHISSMEQFFSYS--DPDDSYPIEG----------LNKAWPGPLT TVN1298 KIFIAKGRPSDNPLIVHISDMDQLENFSK-NVKEEYKAI-----------LKELWPGPLT TM0852 KIFKLKERPADNPLIVHIHSFKQLEEIA---EGYEPHLDF----------LKKFWPGPLT APE2397 RIFEVKGRPPDNPLIVHVSSLEMARTVAE-IPGKALRLV------------EKLWPGPLT Rv1301 ALLSAKGRGRDMPVGVLVGSWHTIEGLVY-SMPDGAREL-----------IRAFWPGALS ML1136 ALLSAKGRGRDMPVGVLVGSWHTIEGLVY-TMPDGAREL-----------IRAFWPGALS L189883 KLYSVKGRPTERALNMNISSFEDILKYSI-NQPVYLQKI-----------VEAFLPGPLT SPy1143 AVYDLKQRPRDKAMNLNVADFNSILAFSK-EQPRYLKKL-----------YQAFLPGPLT BBT06 MINLVKKKSINEPLMLYVDTIEKIKELSS-HVPKSAKIL-----------MEKFSPGPLT BBU11 MINLVKKKSINEPLMLYVDTIEKIKELSS-HVPKSAKIL-----------MEKFSPGPLT BB0734 MIFLVKKRPINNPLIVHVDTVKKIKELSE-YIPKSALML-----------IKKFSPGPLT MG259_2 TLDKIKQRALNKHYVSMFGLEELKK------LPKKLQQI-----------ASYFWPGSYT MPN362_2 DLDHIKQRDPNKHYVQFLAPSQINQ------LPKQLQKL-----------AKLFWPGAYT YGL169w SIYRAKNRPSDNPLITHVSSIDQLNRKVFNQPHLSGTSLFDNIPSIYRPLISSLWPGPLT sll0216 RVRQLKQLSNNKPLTFLCSSLSNIAEYAV--VADDAYRL-----------MRKLIPGPYT RP848 KIFQFKNRPAINPLIVHVTSIVQAKAIG--EFNKLAEKI-----------ASKFWPGPLS VC1079 QIFSAKGRPANHPLIVHLGSAEQLSEWAT-DIAPEAYQL-----------AEAFWPGPLT AF0781 RLYEIKGRSLNKPFIVGVWSRDYVGKIAE--VDERAEKL-----------MEAFFPGPLT VNG2312C AAFEAKRRPREKPLSFAFPDVEAAVEHVA--VGETERAF-----------MAEFLPGPVT MTH1692 RLFRVKGRSPHKPVSICVSCVDEIPRFSR--PSGDAMEL-----------MERILPGPYT aq_651 RLYKIR-RPSGKPFLVLLPDESWLEKLCL-DVKEEHKKL--------------LKVEGLT MJ0062 KVYNIKRREFNKPLSICVRDKNEIEKYAY--VNDLAKKI-----------IDKFLPGPLT UU005m VIYEIKQRDRNKKIIRFVADYKLLG-----DLTVEQKQF-----------LDLFWPGSVT CT137 RLFALKHRSSQKALSVYVSSLEELEAVAQQSLGASSRKI-----------IQKFLPGPLT CPn0270 RLYALKDREPSKAFALYVNSIEDIENISGYPLSPTAKKL------------AQLFPGAIT DR1862 ELYRRKGREANKPLQLSCPGAAAALALAV--PSPALLAL------------SACWPGPLT sll1866 LIYELKQREASKPLILMAATVEQILPYLAGSQREKQLWQAV---------MAEYWPGALT TP0182 DLICLKARGCTETEGNRREGYPFIALLADPQDVVVYTGTRLP------AEFRALWPGPYT slr0006 QLRAFKQFDKDQPLGILTRGDRAMDVAK---IPPAAKKL-----------MG-LFPLPIT : : yciO FILK-----GTKEVPRRLLQEKRKTIGMRVPSNPIAQALLEALGEPMLSTSLMLPGSE-F ZyciO FILK-----GTKEVPRRLLQEKRKTIGMRVPSNPIAQALLEALGEPMLSTSLMLPGSE-F VC1178 FIFK-----GTKEVPRRLMNEKRKTIGIRVPNNKIALDLLEALGEPLMSTSLILPGND-F HI1198 FILT-----ATKELPRRLMTSKRKTIGLRVPDNKIALDLLSALGEPILSCSLMLPNEEHT PM0662 FILT-----ATKELPRRLMTSKRKTIGIRVPDNQIALALLSTLGEPILSCSLMLPGEENV NMB0436 FILQ-----ATKDVPARTLHPKRKTIGLRIPDNAIAQALLGELGEPLLSCTLMLPEDG-E NMA2049 FILQ-----ATKDVPARTLHPKRKTIGLRIPDNAIAQALLGELGEPLLSCTLMLPEDG-E PA3199 FILS-----ATREVPRMLLHPKRRTIGLRVPNCPIARALLEELGEPLMSVSLIMPGSG-E yrdC FVFP-----APATTPRWLTGRFDS-LAVRVTDHPLVVALCQAYGKPLVSTSANLSGLP-- ZyrdC FVFP-----APATTPRWLTGRFDS-LAVRVTDHPLVVALCQAYGKPLVSTSANLSGLP-- HI0656 WIVP-----AKSTTPHFLTGKFDS-IAIRLCDHPSVKALCELTGFALTSTSANLTGEP-- PM1270 WVVP-----AKTTTPKFLTGQFDS-IAVRLCDHPAVKQLCEQAGFALTSTSANLTTLP-- VC0054 WVMP-----ASGDTPSWVRGQFDT-VAVRVSDHPVVQKLCLAFGKPLTSTSANLSGQP-- BU494 FLLP-----AKPNTPYWLTGKFNT-VAVRVSAHFEIIKLCNAFGQAVVSTSANISNMT-- PA0022 WLVP-----HQERLPEWVTGVHDS-VAVRVTDHPLVQELCHLT-GPLISTSANPAGRP-- XF0919 WVLP-----ASTRAPHWITGHHNG-LAVRISAHPLVSALCRAWNMALISTSANVAGQP-- NMB2150 FLLS-----AKSCVLPELRGKQRSKLAVRVPAHVGARRLCQALQTPLVSTSCNRAGKR-- NMA0237 FLLS-----AKSCVLPELRGKQRSKLAVRVPAHVGARRLCQALQTPLVSTSCNRAGKR-- BS_ywlC LILPC-----KPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKP-- BH3771 IIFP------KGEEVSTVVTAGLDTVAVRMPSHPVAQALIEAANVPIAAPSANRSGKP-- PH0435 IVLP------RKDVVPDVTTGGLDTVAIRMPANEIALKLIELSGKPIAAPSANISGKP-- PAB1302 LVLP------KSEVVPRVITGGLDTVAVRMPAHEIALKLIELSERPIAAPSANISGKP-- mlr7439 LVLPQ----RPGNGIHPLVTAGLDTIALRMP-RGFGGDLIAKLGRPLAAPSANSSGRI-- CC3390 IVAPI----RDPEAVCDLARAGLDTVAIRVPGHPLSRAVLAAFGGAVVAPSANRSGRP-- Ta0302 VVVR-----KAQG-ISDVVTAGLPTVAIRMPDDPIAHDLIEMAG-PIAAPSANISTRP-- TVN1298 VVVE-----KANG-IPDTVTAKLPTVAIRMPDDSIARNLIDMAG-PIAAPSANISTKP-- TM0852 VIFR-----KKSEKIPPVVTADLPTVAVRMPAHPVALKLIELFGHPIAAPSANISGRP-- APE2397 LVLP-----RKPV-VPDIVTAGLETVAVRMPAHKVALELVKAAGRPVAAPSANPSGRP-- Rv1301 LVVV------QAPSLQWDLGDAHGTVMLRMPLHPVAIELLREVG-PMAVSSANISGHP-- ML1136 LVVV------HAPSLNWDLGDAHGTVMLRMPLHSVAIELLCEVG-PMAVSSANVSGQP-- L189883 IILE------ASKDVPEWIHIGKSTVGFRMPNIAVTQKIIKEVG-VLVGPSANLSGSK-- SPy1143 IILK------ANDQVPYWINSGLSTVGFRLPSHPITAALIQKTG-PLIGPSANLSGKA-- BBT06 YVLK------KSIKIPKFINNNLDTVAIRIPKNKTALNLIRKLKNPLVVSSANLSKRP-- BBU11 YVLK------KSIKIPKFINNNLDTVAIRIPKNKTALNLIRKLKNPLVVSSANLSKRP-- BB0734 YVLK------KSIKISRFVSGNLDTVAIRIPANKTALSLIKASKVPIVAPSANISKRP-- MG259_2 FIKN-----------NKS---------YRVPKNLGLLNLFNAIG-RVFCTSANISNQKPY MPN362_2 FIVD-----------GQS---------YRLPNSPQLLKLLKTVG-LIYCTSANQAKQKPF YGL169w ILLPVP--SSEHSALSKLTTADQPTFAVRIPANPVARALIALSDTPIAAPSANASTRP-- sll0216 FLLP-----ATKQVPKLVVEPKRKTTGIRVPDRPICQEILQSLGNPIISTSAHLPDQDEF RP848 IVVP----LKDNVNIAPSVTAGLNTIALRIPSYPIALALIRQSVVPIAAPSANPSNYI-- VC1079 LLLP------KAKQVSPVVTGGLESVGIRVPAHPVLLDILKTHRLAVAAPSANPYKKL-- AF0781 LVLK------SKGVMPSLLSPKGK-IAVRMPAHEVPLQLMEMLRKPIVVPSANLSGRP-- VNG2312C VVCE------KRDSVPDVLTGGRDRVGVRVPDSEVAVALLERVA-PLTATSANVSGEP-- MTH1692 VVLE------RNELIPDVITGGSSRVGIRVPDDEICRRIAARF--PVTATSANISGKP-- aq_651 LVFR------KTCDKLDYVSKG--TLAVRLPQKGFIRDLLSELKKPVVAPSVNPEGKK-- MJ0062 IILK------KKPGIPDIVAK--DYIGIRIPDEPIIRELSIVP---LTTTSANISGKE-- UU005m IIKN------------------G--ISYRMPNSPYILKLIQKLG-PLYCSSANISGEE-- CT137 LITK----------HN-NPRFPQKTLGFRIVNHPIVQQIIQKVG-PFLATSANLSGFP-- CPn0270 LVVK----------HR-NPRFPKETLAFRIVDHSVVREIVDHCG-TLIGTSANLSEFP-- DR1862 VVTPGRPERLEDWGAGAEAVAPDGWLGLRVPAHPVALALLSAAGGPLATTSLNPSGQAAA sll1866 LVLP-----CSEKLPPEINPRQDQTIGVRIPRQAISLEILLQTG-PLATTSANLSGQP-- TP0182 FVLR---------------MQDGATQAFRCPADLWLRSVIRAVGGAIFSTSANRHGEP-- slr0006 LIVE------ALPKLDPGITQGFRNIFIACP-DAFVFDLVGAMPFPLVCATAKVGGEP-- : : . : yciO TESDPEEIKDRLEKQVDLIIHG----GYLGQK-PTTVIDLTDDT---PVVVREGVGDVKP ZyciO TESDPEEIKDRLEKQVDLIIHG----GYLGQK-PTTVIDLTDDT---PVVVREGVGDVKP VC1178 TESDPEEIRDRLEHAVDVILNG----GYLGQQ-PTTVIDFSDDE---VVVARVGAGDPTP HI1198 TQSDPEEIRDRLEHQVDLIIHG----GYLGQE-PTTVVDLTEES---PVILREGSGSTAP PM0662 TQSDPEEIRDRLEKQVDLIIHG----GYLGAE-PTTVVDLTNDT---PIIIREGSGSTAP NMB0436 PLTDPYEIRERLEHAVDLVIDG----GWCGTE-PTTVVDMTDG----TELVRQGCGDTAV NMA2049 PLTDPYEIRECLEHAVDLVIDG----GWCGTE-PTTVVDMTDG----TELVRQGCGDTAV PA3199 PLNDPYEMRQVLEHQVDLIVDG----GYGGGE-ASTVISLTDTD---PEVIRVGCGDPAP yrdC PCRTVDEVRAQFGAAFP-VVPG----ETGGRLNPSEIRDALTG-----ELFRQG------ ZyrdC PCRTVDEVRAQFGAAFP-VVPG----ETGGRLNPSEIRDALTG-----ELFRQG------ HI0656 PCRTADEVRLQFGSDFP-VLNE----MVGRAHNPSEIRDLRTN-----QLFRQG------ PM1270 PCRTAEEVKTQFGADFP-VLDL----PVGEATNPSEIRDLFTH-----QLFRQG------ VC0054 ACVTQQEVMVQLGNQIAVVVEG----KTSGRHGPSEIRDARSL-----QVLRQG------ BU494 PCFTSEEVFKCFGKDFP-LLNG----KIGNEKNPSKIINIING-----KLIRYV------ PA0022 AARTRLRVEQYFHDELDAILGG----ALGGRRNPSLIRDLVTG-----QVIRPA------ XF0919 PARRREDLDPSLLPHLAGIVDG----PTGGLAQPTSIRDARSG-----HILRL------- NMB2150 ACRTEREVRRQFGRDVW-IVGG----RIGRQKSPSQIIDGETG-----KRLR-------- NMA0237 ACRTEREVRRQFGRDVW-IVGG----RIGRQKSPSQIIDGETG-----KRLR-------- BS_ywlC SPTKAEHVAHDLDGRIAGIVD----GGPTGIGVESTVLSCADDI---PVLLRPGGITKEQ BH3771 SPTSATHVLADLRGKIAGVVD----GGPTAEGVESTVIDCTTTP---PILYRPGGVTREQ PH0435 SPTSAEHVADDFYGKIECIID----GGETRIGVESTVIDLTEHP---PVLLRPGGLPLEE PAB1302 SPTSAHHVAEDFYGKIECIID----GGETRIGVESTVIDLTEWP---PVLLRPGGLPLEE mlr7439 SATTAQAVAADLGARIKLVVD----GGATPVGLESTIVKAEGAG---VRLLRPGGIAAEE CC3390 SPTTYDDAMAETGDKAAAHLD----GGPCAVGLESTVVSVLEGE---VRLLRPGAVTRVQ Ta0302 SITDSRDAIRFLDGRVDVIID----AGPTRFGIESTIIDITKRP---AELLRPGSYAIED TVN1298 SITDSKDAIRFLDGRVDVIID----AGKVKFGIESTIIDLTQDP---VRLLRPGAFSVED TM0852 SATNVKHVIEDFMGKVKLIID----AGDTPFGLESTIVDLTKEK---PVLLRPGPVEVER APE2397 SPTSGEHVIRDLDCMVDVILD----AGETYFGVESTIIDLTRTP---PVLLRPGPIPVEV Rv1301 PPVDAEQARSQLGDHVAVYLD----AGPSEQQAGSTIVDLTGAT---PRVLRPGPVSTER ML1136 AAVDVDGARGQLGELVGVYLD----AGPSAQQAASTIVDLTEAT---PRILRAGPVSVAR L189883 SPSFFADLSPEILENAAVAVQ----D-DSIYGLDTTIIDLTQEK---PKLLRQGAVTKEE SPy1143 SGRVFDHIMQDFDFQVFGYAD----D-PFLTGKDSTILDLSGER---AVILRQGAITKEE BBT06 SSTSFSMALKELNGLVGGIIMPKK-NKDSNIGIESTIIEFDSKDN--VIILRPGAITKKM BBU11 SSTSFSMALKELNGLVGGIIMPKK-NKDSNIGIESTIIEFDSKDN--VIILRPGAITKKM BB0734 SSTNFEMALKELNGLVRGIIKPEE-NKDFNIGIESTVVGFDLKDN--VLILRPGAITKKM MG259_2 TKLSDYQNDSYWIKQPCFIIRSTS--KVQSNNTPSLVYNLDTK-----QLVRTTAKQTKQ MPN362_2 GKLSAYQNDPYWVQQNCFIVQNS----FKSNNEPSLIYNLDTK-----QIVRGSSTQLQR YGL169w SPTLASHVYHDLKDKIPIILDG----GACKVGVESTVVDGLCNP---PTLLRPGGFTYEE sll0216 VMAEKAKLFDLFDKLVDIIIDD----DREPGYQTSSIIDFTDKE---PKVVREGLG-WET RP848 SPTNAEHVTKHFKDNREIFILAPE-IYQCEYGLESTIIDTTTVI---PTILREGFITSEI VC1079 SPTSAQQVLDGLNGRLAAVLDG----GECQHGLESTIVDLTSKP---FRVLRAGPITASE AF0781 SLMRWEHVVEELGSRIDAVVK-----GECKVGVESTIVDLTETP---AKVLRVGAVSVES VNG2312C SVTNPAALDPAFRARVDAVVDA----GESPGGTGSTVVDVARG-----EILRAGAVGDAV MTH1692 PSPRLEEIVRDLDA-VDLVLDA----GDCLDMEPSTVIDLTVNP---PRVLRRGKGPLDP aq_651 PAESVEEAYNYFGNKVDLYID-----AGVIKGEPSTILDLTEG----VKILREGKVKKEE MJ0062 SPTTVDEIDKEVLKKVDYVID----IGKCKYSKPSTIIKIEDDK---IISIREGVIPIQK UU005m PIKNHNEAIFKFGANSKLIYVE----AQQQIGVPSTIVDIDKW-----EYIRRGANVEMV CT137 SAVSADEVKQDFPEEDIVMIS-----GECSIGLESTVIDPEER-----IVYRESAISIAE CPn0270 SALTAQEIFADFADHDLCIFD-----GPCSHGLESTVVASDPL-----YIYREGLISRSV DR1862 TTQAEAEAYALADLTLPEPAGT----ADRPPAAPSTVLRLPAEGEDTARMLRLGGLSQAD sll1866 PLEKLADIAETFPAVHCLDCLSLEQQGPIGKGLPSTVAQWDGAK-EIFQILRQGEVVLQD TP0182 PLQDAQDIDHIFGKHLALTVD-----AGPLTGSPSAVIDLTHPVP---RVLRAGAAPLPL slr0006 -VTSFEAASRYFEGQVPLIGDG----GRCRYARRGTLIDCTLPL---PTIMNFGPISFDD : . yciO FL---------------------------------------------------------- ZyciO FL---------------------------------------------------------- VC1178 FQ---------------------------------------------------------- HI1198 FI---------------------------------------------------------- PM0662 FV---------------------------------------------------------- NMB0436 FGL--------------------------------------------------------- NMA2049 FGL--------------------------------------------------------- PA3199 FMQPA------------------------------------------------------- yrdC ------------------------------------------------------------ ZyrdC ------------------------------------------------------------ HI0656 ------------------------------------------------------------ PM1270 ------------------------------------------------------------ VC0054 ------------------------------------------------------------ BU494 ------------------------------------------------------------ PA0022 ------------------------------------------------------------ XF0919 ------------------------------------------------------------ NMB2150 ------------------------------------------------------------ NMA0237 ------------------------------------------------------------ BS_ywlC IEAVIGP-IHVDKGLSDQN----EKPISPGMKYTHYAPTAPLAICEGS--------PERI BH3771 LEAVLGP-IRIDPALLGKD----EQPKSPGMKYTHYAPEGELTLVEN---------QAAI PH0435 IEKVIGK-VRIHPAVFGKKV---DTPKSPGMKYKHYAPNAEVIVVEGPREKV----KGKI PAB1302 IEKVIGE-IRIHPAVYGKSV---DTAKAPGMKYRHYAPSAEVIVVEGPRDKV----RRKI mlr7439 IEAAIGM-ELLRGGGAGIE--------APGMLASHYAPGAAMRLNAG------------- CC3390 LQQIVG--RLAEAQDDAKR--------SPGRLALHYAPDAPVRINAK------------- Ta0302 LEPVFGP-IVYGDVARGLGEA--KIAITPGMKYRHYSPSTKLILAETRE---------VF TVN1298 LEPLFGK-ITVDKVALGKAEA--KVAITPGMKYRHYSPNKKIFLCKDRE---------VV TM0852 LKELFPE-LVVPDFVRKGNFK--GRPLAPGMKYRHYAPLKPLILVEDLT---------KM APE2397 LERLLEEKILVPPEARGLRAA--DRPLAPGMKYRHYAPDTPLILVDTSPGAVERIVEAAV Rv1301 IAEVLG---VDAASLFG------------------------------------------- ML1136 IAEVLG---VVPASLIA------------------------------------------- L189883 LLKKVPE--LGQIE---------------------------------------------- SPy1143 LLANVPE--LRF------------------------------------------------ BBT06 IEKVLGS--RYKVNYAKETKI--DLKK-----MFSYRLRIPVHTFKRGD---------NI BBU11 IEKVLGS--RYKVNYAKETKI--DLKK-----MFSYRLRIPVHTFKRGD---------NI BB0734 IENELQG--KYTVNYA-ETKM--ELEKSPGNIIEHYKPKIPVYLFKSQD---------NI MG259_2 FHKLITKHQLAI------------------------------------------------ MPN362_2 FQALLAKHKLRH------------------------------------------------ YGL169w IVKLGGEAWSLCKVENKKTVEKGEKVRTPGMKYRHYSPSAKVVLLVPHCEGDGILKGVDR sll0216 LRDLF------------------------------------------------------- RP848 LEELLGVKILKASEINSIVK-------APGMLKKHYSPNVHVRLNAIN------------ VC1079 LSAVLGQEVLQPQVHQVAV---------PGNVDSHYQPKTRLRVIDD-----------LA AF0781 IKKHVEVVVEPRKETYSLS----------CQVYVFVGERALQRIKEFVD----------- VNG2312C REWLAEHA---------------------------------------------------- MTH1692 VLLRGAGDV--------------------------------------------------- aq_651 IEKILNRKL--------------------------------------------------- MJ0062 LARC-------------------------------------------------------- UU005m DMFIKELKDNKTGK---------------------------------------------- CT137 IETVLGAPCANLSKELGFREKIGIHVVKTPADLCSFLLSRPHFKGVICHQP--------- CPn0270 IENIAGTEAKIFHRTSHAFSKHIKIYTVKNQEQLVSFLSGSLDFKGVVCEHP------KP DR1862 LAARLAPLGVRVTL---------------------------------------------- sll1866 ------------------------------------------------------------ TP0182 AGLERRDSPSLPHVGEVCKE---------------------------------------- slr0006 LRPLIPEIILPSHLMK-------------------------------------------- yciO ------------------------------------------------------------ ZyciO ------------------------------------------------------------ VC1178 ------------------------------------------------------------ HI1198 ------------------------------------------------------------ PM0662 ------------------------------------------------------------ NMB0436 ------------------------------------------------------------ NMA2049 ------------------------------------------------------------ PA3199 ------------------------------------------------------------ yrdC ------------------------------------------------------------ ZyrdC ------------------------------------------------------------ HI0656 ------------------------------------------------------------ PM1270 ------------------------------------------------------------ VC0054 ------------------------------------------------------------ BU494 ------------------------------------------------------------ PA0022 ------------------------------------------------------------ XF0919 ------------------------------------------------------------ NMB2150 ------------------------------------------------------------ NMA0237 ------------------------------------------------------------ BS_ywlC QHLIQEYQQGGRRVGV------------LTTEEKAG------VYSADYVKSCGRRAQLET BH3771 QTFVDKWREKQFKVGI------------MATDEHKQ------DYDADVILSVGSRNDLAE PH0435 TELVKELKERGKKVGV------------IGSES----------YNADEFFFLG--SSVEE PAB1302 EELIAKFKEEGKKVGV------------IGSGS----------YDADEVFYLG--DTVEE mlr7439 ---MVGEGEALLGFGG------------NRAEG---------WRNATAFLNLSASGDLRE CC3390 ---TPEAGEAYLAFG-----------------P---------WPESPRVFNLSPTGDLAE Ta0302 RQILDTVDEDMVVLAT------------EEMVDG-----------HKKAIIIGTDRDLYS TVN1298 ESLKEELPNNGVLMCT------------EEVSQGI----------STNKIIVGRDSDLYS TM0852 EEVLKKYP-DHVVICV------------EERKEL-----------YDDRIVVGSLKNPYS APE2397 REVARARGLRVALVGP------------DELVDVVALLLRLRGVEPAAIFRLGPLADTTV Rv1301 ------------------------------------------------------------ ML1136 ------------------------------------------------------------ L189883 ------------------------------------------------------------ SPy1143 ------------------------------------------------------------ BBT06 RKYLKTNTKVLITRDT------------FKFYFFS---------FLWDKKNIILFDSLIE BBU11 RKYLKTNTKVLITRDT------------FKFYFFS---------FLWDKKNIILFDSLIE BB0734 RRYLNKDTKILITKAT------------LKSYLFN---------FFWNKKNITVFNTLEE MG259_2 ------------------------------------------------------------ MPN362_2 ------------------------------------------------------------ YGL169w MERLKRLIETELKANSNIKKIAILTSLKLRDSDLQSKIFNEPDFSSKTFIIERLGQSGEE sll0216 ------------------------------------------------------------ RP848 ----LNDKEIGLNFGN-------------------------SNLTGKFALNLSTEGNIIE VC1079 RELATQSDELRIALLN------------LSALQ-----------ASEQRLLKPMPQEAKA AF0781 ---EAEKRGRVVVIAR--------------------------EKITDETIVIG--KSAEE VNG2312C ------------------------------------------------------------ MTH1692 ------------------------------------------------------------ aq_651 ------------------------------------------------------------ MJ0062 ------------------------------------------------------------ UU005m ------------------------------------------------------------ CT137 HPHTFYSVLRQALRSP----------------------------TQEIIFVYDLCNTEYP CPn0270 KNFYTRLREALKKKTP-----------------------------SIVFIYDIN-TSDYP DR1862 ------------------------------------------------------------ sll1866 ------------------------------------------------------------ TP0182 ------------------------------------------------------------ slr0006 ------------------------------------------------------------ yciO ------------------------------------------------------------ ZyciO ------------------------------------------------------------ VC1178 ------------------------------------------------------------ HI1198 ------------------------------------------------------------ PM0662 ------------------------------------------------------------ NMB0436 ------------------------------------------------------------ NMA2049 ------------------------------------------------------------ PA3199 ------------------------------------------------------------ yrdC ------------------------------------------------------------ ZyrdC ------------------------------------------------------------ HI0656 ------------------------------------------------------------ PM1270 ------------------------------------------------------------ VC0054 ------------------------------------------------------------ BU494 ------------------------------------------------------------ PA0022 ------------------------------------------------------------ XF0919 ------------------------------------------------------------ NMB2150 ------------------------------------------------------------ NMA0237 ------------------------------------------------------------ BS_ywlC VAAGLYDALRSFDENK----VDFIIAESFPDTGVGLAIMNRLMKAAGGRVIR-------- BH3771 VAHNLYHVLRQFDEQK----VDVIIGETFPREGIGVAIMNRLEKAAGGRIIQR------- PH0435 VAKNLFKALRYMDKAG----VDVVIAEGVEERGLGLAVMNRLRKASGYKIVKA------- PAB1302 IARNLFKALRHMDRTG----VDVILAEGVEEKGLGLAVMNRLRKASGYRIIKV------- mlr7439 AASNLFAYMQELDRSG----ARTIAVETIPFDGLGEAINDRLARAAAPRDNAQPTT---- CC3390 AAANLFAFLRAADRIR----PSAIAVAPIPEEGLGEAINDRLRRAAGYVG---------- Ta0302 VAHNLFSSFIALDDMH----VDLALIHPFEERGIGFALMNRIRKASYRTVKSRE---DFL TVN1298 VAHNLFSSFIELDDSS----YNYGVIIPFEEKGIGLAIMNRIRKASTAVISSSEELKEYL TM0852 IAQNIFSALREAEKMG----KEYIIVEGFEERGILFAVMNRLRKAATEIVR--------- APE2397 AARRLFKTLRRIDELGN---IDVAIVLPFPERGIGLAVMNRLRKAASRRVGA-------- Rv1301 ------------------------------------------------------------ ML1136 ------------------------------------------------------------ L189883 ------------------------------------------------------------ SPy1143 ------------------------------------------------------------ BBT06 YAENLYKELVNAEEKY-----DQVIVEIVENEELGYAINNRIVKASSNNFM--------- BBU11 YAENLYKELVNAEEKY-----DQVIVEIVENEELGYAINNRIVKASSNNFM--------- BB0734 YAQNLYKELVNSENNY-----KQILSEFLKDEELGHSINNRIKKASSNRFINKK------ MG259_2 ------------------------------------------------------------ MPN362_2 ------------------------------------------------------------ YGL169w IQTNLFAALRKVDENDK---VDLIFVEGINEEGEGLAVMNRLRKAAANNCIQF------- sll0216 ------------------------------------------------------------ RP848 AAANLYSYLRILDDYAVSNDINCIAVAPVPLTNIGAAINDRLKRAAKS------------ VC1079 YGQALYRSLAEVDKWG----VDEIWLERPPQGEAWLAVHDRLRRAAS------------- AF0781 YSANLFSAVREAESRR----PDIIVIEGVEN----EAIMDRLRRLAGERVFRV------- VNG2312C ------------------------------------------------------------ MTH1692 ------------------------------------------------------------ aq_651 ------------------------------------------------------------ MJ0062 ------------------------------------------------------------ UU005m ------------------------------------------------------------ CT137 ILSRFLGVSYDSGYAL-------------------------------------------- CPn0270 ELFPFLSPYYIE------------------------------------------------ DR1862 ------------------------------------------------------------ sll1866 ------------------------------------------------------------ TP0182 ------------------------------------------------------------ slr0006 ------------------------------------------------------------ yciO ----------------- ZyciO ----------------- VC1178 ----------------- HI1198 ----------------- PM0662 ----------------- NMB0436 ----------------- NMA2049 ----------------- PA3199 ----------------- yrdC ----------------- ZyrdC ----------------- HI0656 ----------------- PM1270 ----------------- VC0054 ----------------- BU494 ----------------- PA0022 ----------------- XF0919 ----------------- NMB2150 ----------------- NMA0237 ----------------- BS_ywlC ----------------- BH3771 ----------------- PH0435 ----------------- PAB1302 ----------------- mlr7439 ----------------- CC3390 ----------------- Ta0302 DLLG------SIREKVN TVN1298 DEYGISDNTKEIKDKT- TM0852 ----------------- APE2397 ----------------- Rv1301 ----------------- ML1136 ----------------- L189883 ----------------- SPy1143 ----------------- BBT06 ----------------- BBU11 ----------------- BB0734 ----------------- MG259_2 ----------------- MPN362_2 ----------------- YGL169w ----------------- sll0216 ----------------- RP848 ----------------- VC1079 ----------------- AF0781 ----------------- VNG2312C ----------------- MTH1692 ----------------- aq_651 ----------------- MJ0062 ----------------- UU005m ----------------- CT137 ----------------- CPn0270 ----------------- DR1862 ----------------- sll1866 ----------------- TP0182 ----------------- slr0006 -----------------