y a o g gggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggg 11 22 30 48 ||||||--|||||-|-|-||||||--|||||---||||----|||||-||-|||||||||||||-- 61 [H] COG0001 Glutamate-1-semialdehyde aminotransferase 10 21 30 46 |||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||-- 48 [E] COG0002 Acetylglutamate semialdehyde dehydrogenase 8 15 16 20 ||-|||-|-||-|||-|-|||------|||-----|-|---------------------------- 34 [P] COG0003 Oxyanion-translocating ATPase 10 21 26 40 |||-||--||-|-||-||||-|----|||-||--|||||---|||||--|--||||---|||||-- 58 [P] COG0004 Ammonia permease 9 20 25 36 |||||||||||||||-||||-------||||-||-|||----|--||--|--|------||-|--- 46 [F] COG0005 Purine nucleoside phosphorylase 14 28 38 65 |||||||||||||||||||||||||||||||||||||||||||||||-|||||||||||||||||| 131 [E] COG0006 Xaa-Pro aminopeptidase 10 21 28 44 ||||||--|||||||-|-||||----|||||---||||----||||||||--||||---|||||-- 67 [H] COG0007 Uroporphyrinogen-III methylase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 111 [J] COG0008 Glutamyl- and glutaminyl-tRNA synthetases 14 27 37 63 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||---||||||| 82 [J] COG0009 Putative translation factor (SUA5) 8 21 29 41 |||||||||||||||---||||--------|-|-|-||----|||-|-||-|||||||-||||--- 78 [E] COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family 8 15 16 22 ||-||||||||--|--|||-------|||-|--||-||---------------------------- 25 [S] COG0011 Uncharacterized conserved protein 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 71 [J] COG0012 Predicted GTPase, probable translation factor 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 66 [J] COG0013 Alanyl-tRNA synthetase 10 16 23 39 --|----------||-||||-|--|-||||||||-|||----|||||-||||||||--||||||-- 41 [E] COG0014 Gamma-glutamyl phosphate reductase 11 24 32 54 ||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||-- 67 [F] COG0015 Adenylosuccinate lyase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 68 [J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit 10 21 27 44 ||||||||||||||||--||||--||----|||||||||||||||||||-|||------------- 63 [J] COG0017 Aspartyl/asparaginyl-tRNA synthetases 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 68 [J] COG0018 Arginyl-tRNA synthetase 9 20 27 47 |||-||--||---||-||||-|----||||||-|||||----||||||||||||||||||||||-- 76 [E] COG0019 Diaminopimelate decarboxylase 14 27 37 62 ||||||||||||||||||||||||||||||||||||||----|||||||||||||||||||||||| 76 [I] COG0020 Undecaprenyl pyrophosphate synthase 11 18 25 49 -------------|||||||-||||-||||||||||||||||||||||||||||||||||||||-- 62 [G] COG0021 Transketolase 10 16 21 35 ---|||----||||||--||-|||---||--|||||||-|||-------|-----|---||||||| 56 [C] COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit 5 14 19 26 |||||||||||||||---||----------------------|||||-||||-------------- 29 [J] COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins 14 27 37 65 ||||||||||||||||||||||||||||||-||||||||||||||||||||||||||||||||||| 82 [J] COG0024 Methionine aminopeptidase 8 18 23 34 ||||||-|||---|||--||-|----|||--|-||||-----|||||-||-||------|--|--- 56 [P] COG0025 NhaP-type Na+/H+ and K+/H+ antiporters 10 15 23 41 ---|||----||-||-||||-|----||||-|||||||----|||||-||||||||---|||||-- 41 [F] COG0026 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) 6 8 11 18 -|----||---|------||------|||-------|-----|||||-||-|-------------- 18 [F] COG0027 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) 10 22 31 49 |||-||-||||||||-||||-|----||||||-|||||----||||||||||||||--||||||-- 146 [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] 8 13 18 30 ---|--||---|----|-|||------||||----|||----|||||-||--||||---||-||-- 32 [H] COG0029 Aspartate oxidase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 75 [J] COG0030 Dimethyladenosine transferase (rRNA methylation) 11 20 29 50 --||||-|--|||||-||||||----||||||||||||----||||||||||||||||||||||-- 103 [E] COG0031 Cysteine synthase 5 7 9 18 -------------||---|--|----|||-------------|||||-|----------|||||-- 19 [G] COG0033 Phosphoglucomutase 11 24 32 51 ||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||-- 53 [F] COG0034 Glutamine phosphoribosylpyrophosphate amidotransferase 12 21 29 48 |--|---|--|||||-||||||--|-|||-|||||||||||||||||-||||-|||--||||||-- 52 [F] COG0035 Uracil phosphoribosyltransferase 13 21 28 53 -|--||-------||||||||||||-||||||||||||||||||||||||||||||||||||||-- 65 [G] COG0036 Pentose-5-phosphate-3-epimerase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 120 [D] COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control 10 21 27 41 -|||||||||-||||-|-||||----|||-||||---|----|||||-|-||-|||---|-|||-- 68 [P] COG0038 Chloride channel protein EriC 13 26 34 55 ||||||--|||||||-||||||||-|||||||||||||-||||||||-|-|||--|--|||||||| 71 [C] COG0039 Malate/lactate dehydrogenases 10 21 28 44 ||||----||||-||-||||-|----||||||--||||----|||||||||||||---||||||-- 45 [E] COG0040 ATP phosphoribosyltransferase 11 24 32 51 ||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||-- 51 [F] COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase 13 24 32 54 ||||----||---|||||||||||||||||||||||||----|||||-|||||||||||||||||| 98 [J] COG0042 tRNA-dihydrouridine synthase 9 19 27 41 |||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-||| 51 [H] COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases 11 24 30 48 |||||||||||||||-||||||----||||||||||||----|||-|--|--|--|||||||||-- 69 [F] COG0044 Dihydroorotase and related cyclic amidohydrolases 10 20 29 46 ||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||--|||||||| 50 [C] COG0045 Succinyl-CoA synthetase, beta subunit 11 24 32 51 ||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||-- 51 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain 11 24 32 51 ||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||-- 51 [F] COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 71 [J] COG0048 Ribosomal protein S12 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0049 Ribosomal protein S7 12 19 27 53 ---------|---||-|||||||||||||||||||||||||||||||||||||||||||||||||| 73 [J] COG0050 GTPases - translation elongation factors 14 28 38 65 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-|||||| 68 [J] COG0051 Ribosomal protein S10 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0052 Ribosomal protein S2 12 24 32 47 ||||---||||||||-||||||---||||-||||||||----|||||-||-|---|--|||||||| 67 [P] COG0053 Predicted Co/Zn/Cd cation transporters 12 23 32 51 ||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||-- 55 [H] COG0054 Riboflavin synthase beta-chain 9 16 24 48 --|----------||-|||||-----|||||||||||||||||||||||||||||||||||||||| 53 [C] COG0055 F0F1-type ATP synthase, beta subunit 9 16 24 48 --|----------||-|||||-----|||||||||||||||||||||||||||||||||||||||| 53 [C] COG0056 F0F1-type ATP synthase, alpha subunit 14 28 37 63 ||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||-- 93 [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase 11 16 21 35 -||---||--||-|--|-||||||--|||-||||--||----|||||-||||-------||-|--- 43 [G] COG0058 Glucan phosphorylase 10 20 28 47 |||----|||||-|--||||-|----||||||-|||||----||||||||||||||||||||||-- 49 [EH] COG0059 Ketol-acid reductoisomerase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 69 [J] COG0060 Isoleucyl-tRNA synthetase 12 26 36 62 |||||||||||||||||||||---|||||||||||||||-|||||||||||||||||||||||||| 74 [G] COG0061 Predicted sugar kinase 10 22 28 42 |||||||||||||||-||||-|----|||||-----------|||||-||--|--|||||||||-- 42 [S] COG0062 Uncharacterized conserved protein 11 24 32 49 ||||||||||||||||||||-|----||||||--|||-----|||||-||--||||||||||||-- 52 [G] COG0063 Predicted sugar kinase 13 25 30 50 ||||----||-||||-||||||||||||||||||||||||||-------|---||||||||||||| 52 [J] COG0064 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) 10 22 30 47 ||||--||||||-||-||||-|----||||||--||||----||||||||||||||--||||||-- 56 [E] COG0065 3-isopropylmalate dehydratase large subunit 10 21 29 47 |||---||||||-||-||||-|----||||||-|||||----||||||||||||||--||||||-- 57 [E] COG0066 3-isopropylmalate dehydratase small subunit 10 20 26 39 |||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||-- 45 [E] COG0067 Glutamate synthase domain 1 5 12 12 18 |||---||||------|-||----------|-----------|||-|---------|||------- 20 [O] COG0068 Hydrogenase maturation factor 10 20 26 39 |||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||-- 52 [E] COG0069 Glutamate synthase domain 2 10 20 26 39 |||-----||||-||-||||-|----||||||--||||----|||||-||--|--|--||||||-- 46 [E] COG0070 Glutamate synthase domain 3 10 22 29 44 |||||||||||||||-||||-|-----||||---|-||----||||||||--|--|---||||||| 91 [O] COG0071 Molecular chaperone (small heat shock protein) 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 68 [J] COG0072 Phenylalanyl-tRNA synthetase beta subunit 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 120 [R] COG0073 EMAP domain 10 20 29 46 ||-|||--|||||||-|-||-|||--||||----|-||----|||||-||||||||--|||||||| 57 [C] COG0074 Succinyl-CoA synthetase, alpha subunit 9 20 26 33 ||||||||||||||--||||-|--------||--|-||--------|-||------||-||-||-- 43 [E] COG0075 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase 7 15 18 26 ||||--||||--||----||-------||--|---|-|----||||--|-|---------|||--- 46 [E] COG0076 Glutamate decarboxylase and related PLP-dependent proteins 10 22 30 47 ||||||--||||-||-||||-|----||||||-|||||----|||-||||||||||--||||||-- 47 [E] COG0077 Prephenate dehydratase 11 25 34 54 |||||||||||||||-||||-|---|||||||||||||--|-||||||||||||||--||||||-- 65 [E] COG0078 Ornithine carbamoyltransferase 11 24 33 51 |||||||||||||||-||||||----||||||--||||----||||||||||||||--||||||-- 96 [E] COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 71 [J] COG0080 Ribosomal protein L11 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 69 [J] COG0081 Ribosomal protein L1 12 25 34 56 ||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||-- 56 [E] COG0082 Chorismate synthase 10 18 24 41 -|-|||||-||||||-||||-|----||||||-|||||----|||||||-|||---|||------- 41 [E] COG0083 Homoserine kinase 14 25 35 62 |||---||-||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 90 [L] COG0084 Mg-dependent DNase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 79 [K] COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 92 [K] COG0086 DNA-directed RNA polymerase, beta' subunit/160 kD subunit 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0087 Ribosomal protein L3 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0088 Ribosomal protein L4 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 68 [J] COG0089 Ribosomal protein L23 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0090 Ribosomal protein L2 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0091 Ribosomal protein L22 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 66 [J] COG0092 Ribosomal protein S3 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0093 Ribosomal protein L14 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0094 Ribosomal protein L5 10 15 19 33 ---|||||---||||-||||--||--|----|||||||-||||||||-||---------------- 61 [H] COG0095 Lipoate-protein ligase A 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0096 Ribosomal protein S8 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0097 Ribosomal protein L6P/L9E 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 68 [J] COG0098 Ribosomal protein S5 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0099 Ribosomal protein S13 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 71 [J] COG0100 Ribosomal protein S11 14 28 36 63 |||||||||||--||||||||||||||||||||||||||-|||||||||||||||||||||||||| 69 [J] COG0101 Pseudouridylate synthase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 71 [J] COG0102 Ribosomal protein L13 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0103 Ribosomal protein S9 11 24 32 54 ||||||||||||-||-||||||----||||||||||||----||||||||||||||||||||||-- 55 [F] COG0104 Adenylosuccinate synthase 12 25 35 57 |||||||||||||||||-||-||||||||||--|||||----|||||-|||||||||||||||||| 57 [F] COG0105 Nucleoside diphosphate kinase 10 21 29 45 ||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||-- 45 [E] COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase 10 21 29 45 ||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||-- 47 [E] COG0107 Imidazoleglycerol-phosphate synthase 12 23 32 51 ||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||-- 57 [H] COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase 9 15 21 37 ---|||--|-|||||-|-||-|----||||----||||----||||||-|--|--|---||||||| 41 [O] COG0109 Polyprenyltransferase (cytochrome oxidase assembly factor) 10 21 28 44 ||||---|-||--||--|||-|||--||||||||||||----|||-|-||-|-|||--||||||-| 111 [R] COG0110 Acetyltransferase (isoleucine patch superfamily) 10 23 31 49 |||||||||||||||-||||-|----||||||--||||----|||||-|||||--|||||||||-- 113 [HE] COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases 13 27 37 64 ||||||||||||||||||||-|||||||||||||||||-||||||||||||||||||||||||||| 79 [E] COG0112 Glycine/serine hydroxymethyltransferase 11 23 32 51 ||||||--|||||||-|-||||||--|||||---||||----|||||-||-||||||||||||||| 52 [H] COG0113 Delta-aminolevulinic acid dehydratase 9 14 23 42 --||------|||||---|--|||--||||----||||----|||||-|||||||||||||||||| 43 [C] COG0114 Fumarase 11 22 30 50 ||||----|||--||-||||||----||||||||||||----|||||-|||||||||||||||||| 112 [EH] COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase 7 12 19 32 -|----|||||-|-----|-||--------||||||||----||||||||||||||---------- 32 [L] COG0116 Predicted N6-adenine-specific DNA methylase 10 16 23 42 -------------||-||||||||--||||||-||-||----||||||||||||||||||||||-- 42 [H] COG0117 Pyrimidine deaminase 10 21 29 45 ||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||-- 47 [E] COG0118 Glutamine amidotransferase 10 22 30 47 |||--|||||||-||-||||-|----|||||--|||||----||||||||||||||--||||||-- 102 [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases 10 22 31 48 ||||||||||||||||--||-|||||----||||||------||||||||||||||---|||||-- 49 [G] COG0120 Ribose 5-phosphate isomerase 6 12 17 28 ||--|-||--||-|----||-------||-------------|||||-||||-|||---||||--- 37 [R] COG0121 Predicted glutamine amidotransferase 9 18 22 32 |-||--|||---||||--|--|-----||-|-----||-|--|||||-||--|--|---|||||-- 41 [L] COG0122 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase 9 19 24 31 ||||--|||||||||||-||-|------------|-||----------||---|||---|||||-- 55 [BQ] COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 68 [J] COG0124 Histidyl-tRNA synthetase 14 27 37 65 ||||||||||||||||||||||||||||||-||||||||||||||||||||||||||||||||||| 70 [F] COG0125 Thymidylate kinase 14 28 37 64 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-- 65 [G] COG0126 3-phosphoglycerate kinase 14 27 36 57 ||||||||||||||||||||||||||||||||||||||----|||||-||||||||--||||||-- 59 [F] COG0127 Xanthosine triphosphate pyrophosphatase 12 25 34 56 ||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||-- 58 [E] COG0128 5-enolpyruvylshikimate-3-phosphate synthase 10 21 30 49 |||----||||||||-||||-|----||||||-|||||----||||||||||||||||||||||-- 85 [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase 14 28 38 62 ||||||||||||||||||||||||||||||||||||||||--||||||||||||||--|||||||| 67 [J] COG0130 Pseudouridine synthase 10 21 29 45 ||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||-- 45 [E] COG0131 Imidazoleglycerol-phosphate dehydratase 9 14 20 36 -|-----------|--|-|||--|--|||||---|-||----||||||||||||||||||-|||-- 46 [H] COG0132 Dethiobiotin synthetase 11 23 30 49 ||||---|||---||-|||||||---||||||-|||||----||||||||||||||||||||||-- 50 [E] COG0133 Tryptophan synthase beta chain 10 23 32 52 ||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||-- 56 [E] COG0134 Indole-3-glycerol phosphate synthase 11 24 33 50 ||||||-||||||||-||||-||---|---||-|||||----||||||||||||||||||||||-- 50 [E] COG0135 Phosphoribosylanthranilate isomerase 11 24 34 56 |||||-|||||||||-||||-|||--||||||-|||||----|||||||||||||||||||||||| 68 [E] COG0136 Aspartate-semialdehyde dehydrogenase 10 22 30 47 ||||||--||||-||-||||-|----||||||--||||----||||||||||||||--||||||-- 47 [E] COG0137 Argininosuccinate synthase 10 19 26 44 --||||--|----||-||||||----||||||-|||||----||||||||||||||--||||||-- 46 [F] COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) 10 21 29 45 ||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||-- 45 [E] COG0139 Phosphoribosyl-AMP cyclohydrolase 10 20 28 44 ||||-----|||-||-||||-|----||||||--||||----||||||||||||||--||||||-- 44 [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase 10 21 29 45 ||||----||||-||-||||-|----||||||--||||----||||||||||||||--||||||-- 50 [E] COG0141 Histidinol dehydrogenase 14 27 37 62 ||||||||||||||||||||||||||||||||||||||----|||||||||||||||||||||||| 120 [H] COG0142 Geranylgeranyl pyrophosphate synthase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 71 [J] COG0143 Methionyl-tRNA synthetase 12 22 31 49 -|-|--||||||||||-|||||||--|||-||||||||----|||||-||||||||--||||||-- 96 [J] COG0144 tRNA and rRNA cytosine-C5-methylases 8 15 18 23 -||--|--|||||||-|-||-------|-------|-|------------------||-|||||-- 49 [EQ] COG0145 N-methylhydantoinase A/acetone carboxylase, beta subunit 7 13 16 20 -||--|---||||||-|-||-------|----------------------------||-|||||-- 29 [EQ] COG0146 N-methylhydantoinase B/acetone carboxylase, alpha subunit 11 24 33 54 ||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||-- 102 [EH] COG0147 Anthranilate/para-aminobenzoate synthases component I 14 28 37 64 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-- 72 [G] COG0148 Enolase 14 28 37 64 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-- 69 [G] COG0149 Triosephosphate isomerase 11 24 32 51 ||||||||||||-||-||||||----||||||||||||----|||||-||||||||--||||||-- 51 [F] COG0150 Phosphoribosylaminoimidazole (AIR) synthetase 11 24 32 53 ||||||||||||-||-||||||----||||||||||||----|||||-||||||||||||||||-- 53 [F] COG0151 Phosphoribosylamine-glycine ligase 11 24 33 53 ||||||||||||-||-||||||----||||||||||||----|||||-||||||||--|||||||| 56 [F] COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase 9 11 14 23 ------|---|--||--|--|---|-|||-||-|--||----|||||-|-||-------------- 24 [G] COG0153 Galactokinase 13 25 32 52 ||||----|||||||-||||||||||||||||||||||||||---|---|---||||||||||||| 113 [J] COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases 9 14 20 32 --------|-||-||-|-||-|----|||-|-----||----||||||||--||||---|||||-- 45 [P] COG0155 Sulfite reductase, beta subunit (hemoprotein) 11 18 25 44 -|--||||-----||||-||||||---|||----|-||----|||||-|||||||||||||||||| 78 [H] COG0156 7-keto-8-aminopelargonate synthetase and related enzymes 10 21 29 45 ||||--||||||-|--|||||-----|||||-||-|||----|||||-||||||||||-||-||-- 50 [H] COG0157 Nicotinate-nucleotide pyrophosphorylase 4 9 14 23 ---|---------||---||----------------------|||||-||||-||||||-||-|-- 23 [G] COG0158 Fructose-1,6-bisphosphatase 11 24 33 53 ||||||-||||||||-||||-||---||||||-|||||----||||||||||||||||||||||-- 54 [E] COG0159 Tryptophan synthase alpha chain 8 15 20 34 --||||||--|||||----|-|----|||||---|-||----|||||-|||----|---||||--- 69 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases 9 14 20 37 -|-----------||-|---||-|--|||||---|-||----||||||||||||||||||||||-- 78 [H] COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 74 [J] COG0162 Tyrosyl-tRNA synthetase 9 19 27 41 |||-||||||||||--|-||-|||------------||----|||||-||-|-|||||||||-||| 46 [H] COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase 14 27 37 60 ||||||||||||||||||||||||-|||||||||||||----|||||-|||||||||||||||||| 60 [L] COG0164 Ribonuclease HII 10 22 30 47 ||||||--||||-||-||||-|----||||||--||||----||||||||||||||--||||||-- 51 [E] COG0165 Argininosuccinate lyase 14 23 32 57 -|-|||----||||||||||||||||||||||||||||-|||||||||||||||||||||||||-- 60 [G] COG0166 Glucose-6-phosphate isomerase 11 24 33 55 |||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||-- 67 [F] COG0167 Dihydroorotate dehydrogenase 11 23 27 43 ||||--||||--|||-||||||--||------||||||-||||||||-||||-||---||||---- 60 [P] COG0168 Trk-type K+ transport systems, membrane components 12 25 34 56 ||||||-||||||||-||||||||--||||||||||||----||||||||||||||||||||||-- 78 [E] COG0169 Shikimate 5-dehydrogenase 8 16 16 20 |||-|||||||--||||-||----||--------------------------------------|| 25 [I] COG0170 Dolichol kinase 12 26 34 59 |||||||||||||||-||||||--||||||||||||||||||||||||||--||||||||||||-- 65 [H] COG0171 NAD synthase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0172 Seryl-tRNA synthetase 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 52 [J] COG0173 Aspartyl-tRNA synthetase 10 22 32 54 |||||||||||||||-||||-|----||||-|||||||----|||||-|||||||||||||||||| 101 [E] COG0174 Glutamine synthetase 9 19 26 39 -||||-||-||||||---||||----|||-|-----||----||||||||--||||---|||||-- 73 [EH] COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes 10 17 23 44 -|--||-------||-||||-|||--|||||-||||||----||||||||||-|||||||||||-- 64 [G] COG0176 Transaldolase 14 27 37 62 ||||||||||||||||||||||||||||||||||||||----|||||||||||||||||||||||| 70 [L] COG0177 Predicted EndoIII-related endonuclease 11 19 27 52 |-||------------|||||||||||||||||||||||||||||||-|||||||||||||||||| 59 [L] COG0178 Excinuclease ATPase subunit 8 20 27 43 |||||||||||||||---||-|----||||----||||----|||||-||-|-|||--||||||-- 78 [Q] COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 72 [J] COG0180 Tryptophanyl-tRNA synthetase 11 23 32 52 ||||||--|||||||-|-||||||--|||||---||||----||||||||-||||||||||||||| 52 [H] COG0181 Porphobilinogen deaminase 9 18 21 24 |||-|||||||||||-|||||---------------|------------|--|-------|-|--- 24 [J] COG0182 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family 11 23 31 49 ||||||||||||||||--|-||---||||||||-||||----|||||-|||----|||-||||||| 189 [I] COG0183 Acetyl-CoA acetyltransferase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 69 [J] COG0184 Ribosomal protein S15P/S13E 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 69 [J] COG0185 Ribosomal protein S19 14 28 38 65 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||-|||||| 70 [J] COG0186 Ribosomal protein S17 13 23 31 58 --||||--|----||||||||||||||||||||||||||||||||||||||||||||||||||||| 94 [L] COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit 13 23 31 58 --||||--|----||||||||||||||||||||||||||||||||||||||||||||||||||||| 96 [L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit 6 14 22 34 -|||--|||-|||-----||-|---------------|--||||||||||||||||---|||||-- 55 [HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) 13 22 31 57 --||||----||-||-|||||||||||||||||||||||||||||||||||||-|||||||||||| 64 [H] COG0190 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase 9 16 22 45 -------------||-||||-|--||||||||||||||||||||||||||||-||||||-||||-- 71 [G] COG0191 Fructose/tagatose bisphosphate aldolase 10 17 24 48 -------------||-||||||--||||||||||||||||||||||||||||||||||||||||-- 51 [H] COG0192 S-adenosylmethionine synthetase 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 53 [J] COG0193 Peptidyl-tRNA hydrolase 11 18 26 51 -------------|||||||||||--|||||||||||||||||||||||||||||||||||||||| 53 [F] COG0194 Guanylate kinase 12 25 35 63 |||||||||||||---|||||||||||||||||||||||||||||||||||||||||||||||||| 71 [K] COG0195 Transcription elongation factor 11 18 25 49 -------------||-|||||||||-||||||||||||||||||||||||||||||||||||||-- 51 [H] COG0196 FAD synthase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 69 [J] COG0197 Ribosomal protein L16/L10E 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 68 [J] COG0198 Ribosomal protein L24 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 76 [J] COG0199 Ribosomal protein S14 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 69 [J] COG0200 Ribosomal protein L15 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [U] COG0201 Preprotein translocase subunit SecY 14 27 37 65 ||-||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 68 [K] COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 52 [J] COG0203 Ribosomal protein L17 12 19 27 52 -------------||||||||||||||||||||||||||||||||||-|||||||||||||||||| 137 [I] COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase 12 17 21 42 -------------||||||||||||||||||||||||||||||||||||-|||------||-|--- 50 [G] COG0205 6-phosphofructokinase 10 23 31 57 ||||||||||------||||||--||||||||||||||-||||||||||||||||||||||||||| 81 [D] COG0206 Cell division GTPase 8 17 24 44 |||-----||---|||----||----||||||||||||-|||||||||||||||||---|||||-- 47 [F] COG0207 Thymidylate synthase 13 19 27 49 ---|-------|-||||-|-|||||-||||||||||||-|||||||||||||||||||||-|-||| 62 [F] COG0208 Ribonucleotide reductase, beta subunit 14 25 35 61 |-|||||||-|||||||||-|||||-||||||||||||-||||||||||||||||||||||||||| 88 [F] COG0209 Ribonucleotide reductase, alpha subunit 12 22 30 57 |-||||-------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 123 [L] COG0210 Superfamily I DNA and RNA helicases 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 52 [J] COG0211 Ribosomal protein L27 12 21 31 52 |--|-----||||||-|-|||||||-||||||-|||||--|||||||-|||||||||||||||||| 55 [H] COG0212 5-formyltetrahydrofolate cyclo-ligase 6 13 15 29 -||---|||--------|---|-----||-||-||||||||||||-|-|------|---||-|--- 30 [F] COG0213 Thymidine phosphorylase 9 18 21 30 |||||||||||||||--|--||----|||||--|||||------------||-------------- 32 [H] COG0214 Pyridoxine biosynthesis enzyme 14 25 35 63 --|||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||| 67 [J] COG0215 Cysteinyl-tRNA synthetase 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 52 [J] COG0216 Protein chain release factor A 11 18 26 51 -------------||-|||||||||||||||||||||||||||||||-|||||||||||||||||| 58 [S] COG0217 Uncharacterized conserved protein 7 17 25 47 -|||--||||---|--||--|---------|||||||||||||||||||||||||||||||||||| 47 [R] COG0218 Predicted GTPase 7 13 20 40 ------------------||||||--|||||||||-|||||||||||-||||||||--||||||-- 41 [J] COG0219 Predicted rRNA methylase (SpoU class) 12 19 27 52 -------------||||||||||||-|||||||||||||||||||||||||||||||||||||||| 52 [R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase 12 24 32 55 |-||||||-|-||||||-||||||--|||||----|-||||||||||||||||||||||||||||| 59 [C] COG0221 Inorganic pyrophosphatase 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 55 [J] COG0222 Ribosomal protein L7/L12 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 64 [J] COG0223 Methionyl-tRNA formyltransferase 9 16 24 48 --|----------||-|||||-----|||||||||||||||||||||||||||||||||||||||| 50 [C] COG0224 F0F1-type ATP synthase, gamma subunit 10 19 26 48 |-||-------|-||---||||--|-|||||||||||||||||||||-||||||||||||||||-- 62 [O] COG0225 Peptide methionine sulfoxide reductase 10 22 30 48 ||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||-- 78 [P] COG0226 ABC-type phosphate transport system, periplasmic component 11 18 26 50 -------------||-|||||||||||||-|||||||||||||||||||||||||||||-|||||| 53 [J] COG0227 Ribosomal protein L28 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 52 [J] COG0228 Ribosomal protein S16 9 18 25 45 |-||---------||---||||--|-|||-||||||||-||||||||-||||||||||||||||-- 53 [O] COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase 10 17 25 50 -------------||-||||-||||||||||||||||||||||||||||||||||||||-|||||| 50 [J] COG0230 Ribosomal protein L34 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 78 [J] COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) 5 7 12 24 ------------------|--|----||||-----|------|||||-||||---|---||||||| 28 [F] COG0232 dGTP triphosphohydrolase 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 52 [J] COG0233 Ribosome recycling factor 12 19 27 51 --|----------||-||||||||||||||||||||||--|||||||||||||||||||||||||| 58 [O] COG0234 Co-chaperonin GroES (HSP10) 10 23 31 47 ||||-||||||-|||-||-||------||||-||-|||-||-|||||-|||||--|||--|||||| 87 [G] COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases 12 19 27 53 --|----------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 115 [IQ] COG0236 Acyl carrier protein 14 28 38 65 ||||||||||||||||||||||||||||||||||||||-||||||||||||||||||||||||||| 67 [H] COG0237 Dephospho-CoA kinase 11 18 26 51 -------------||-|||||||||||||||||||||||||||||||||||||||||||-|||||| 53 [J] COG0238 Ribosomal protein S18 9 19 26 43 -|||--||-|---||-||||-|----|||-|--|||||----|||||-||||||||||||||||-- 60 [D] COG0239 Integral membrane protein possibly involved in chromosome condensation 13 21 29 52 |-------|----|||||||||||||||||||||||||||--|||||-|||||||||||||||||| 56 [C] COG0240 Glycerol-3-phosphate dehydrogenase 8 13 19 30 -|--||-------|||--|-|------||-|-----------|||||||||||||||||---||-- 39 [E] COG0241 Histidinol phosphatase and related phosphatases 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 65 [J] COG0242 N-formylmethionyl-tRNA deformylase 8 18 24 39 ||-||||||||||---|-||-|----|||-------||----|||||-||||---|||||||||-- 149 [C] COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0244 Ribosomal protein L10 10 16 22 41 ----------------|||||||||-|||||----|||--||||||||||||||||||||||||-- 41 [I] COG0245 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 5 9 14 26 -------------|---|--------|---||-||-||-||-||||||||-|---|---|||||-- 54 [G] COG0246 Mannitol-1-phosphate/altronate dehydrogenases 9 19 26 42 ||||||--|||||---|-||||----||||-|----||----|||||-||||-||||||||||--- 115 [C] COG0247 Fe-S oxidoreductase 11 16 23 38 --|--------|-|--||||||----|||||------|----|||||-|||||||||||||||||| 54 [FP] COG0248 Exopolyphosphatase 12 19 27 44 --||-|-------|||||||||||||----|||-||||----||||||||||||||---||||||| 59 [L] COG0249 Mismatch repair ATPase (MutS family) 13 26 36 64 |||||||||||||-|-|||||||||||||||||||||||||||||||||||||||||||||||||| 72 [K] COG0250 Transcription antiterminator 11 18 27 48 ---|--||--|||||-||||||----||||||||||||----||||||||||||||||||||||-- 142 [J] COG0251 Putative translation initiation inhibitor, yjgF family 8 20 28 46 |||||||||||||||-----||----||||||||||||----|||||-|||-||||||||-|---- 64 [EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D 9 17 24 44 ||------||------|||||-||--|||||---||||----|||||||||||||||||||||||| 46 [E] COG0253 Diaminopimelate epimerase 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 64 [J] COG0254 Ribosomal protein L31 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 69 [J] COG0255 Ribosomal protein L29 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 67 [J] COG0256 Ribosomal protein L18 10 17 25 50 -------------||-||||-||||||||||||||||||||||||||||||||||||||-|||||| 56 [J] COG0257 Ribosomal protein L36 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 90 [L] COG0258 5'-3' exonuclease (including N-terminal domain of PolI) 5 9 15 25 -------------||---||-|-----|||------------|||||-|||-||||---|||||-- 28 [H] COG0259 Pyridoxamine-phosphate oxidase 11 16 23 44 ------------|-|||-||||||--||||----|-|||||||||||||||||-|||||||||||| 61 [E] COG0260 Leucyl aminopeptidase 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [J] COG0261 Ribosomal protein L21 10 15 23 45 --|----------|||-|--||||--||||||||||||||||||||||||||||||---|||||-| 68 [H] COG0262 Dihydrofolate reductase 10 16 23 39 --|----------||-||||-|--|-||||||||-|||----|||||-||||||||--||||||-- 43 [E] COG0263 Glutamate 5-kinase 11 17 25 51 --------------|-|||||||||||||||||||||||||||||||||||||||||||||||||| 51 [J] COG0264 Translation elongation factor Ts 13 21 30 53 |-||------||-||-||||||||||||||||||||||----|||||||||||||||||||||||| 134 [O] COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain 5 9 17 37 ------------------||-|----||||-||||||||||||||||-||||||||---|||||-| 50 [L] COG0266 Formamidopyrimidine-DNA glycosylase 11 18 26 51 -------------||-|||||||||||||||||||||||||||||||||||||||||||-|||||| 63 [J] COG0267 Ribosomal protein L33 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [J] COG0268 Ribosomal protein S20 4 11 16 24 |||---|||||||-----------------|-|||-|--||-|||-|-|-||-------------- 30 [G] COG0269 3-hexulose-6-phosphate synthase and related proteins 7 16 24 34 ||----||-||||-|---||------|---|-||--||||--|||-|-|-|-||||||--|-||-- 63 [L] COG0270 Site-specific DNA methylase 4 8 15 26 ---|---------||---||----------------------||||||||||||||---||||||| 37 [T] COG0271 Stress-induced morphogen (activity unknown) 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 57 [L] COG0272 NAD-dependent DNA ligase (contains BRCT domain type II) 10 16 20 39 |--|||----|-|---||||-|--|-|||||||||||||||||||||-|-||-------||-|--- 44 [F] COG0274 Deoxyribose-phosphate aldolase 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [M] COG0275 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis 9 14 22 43 ----||-------||-|-||-|||--||||-|-|||||----|||||-|||||||||||||||||| 44 [H] COG0276 Protoheme ferro-lyase (ferrochelatase) 10 19 27 43 --||||--|-|||||-|-||||----|||||-----||----|||||-||||||||||||||||-- 171 [C] COG0277 FAD/FMN-containing dehydrogenases 5 9 16 27 ---|---------|||--||----------------------||||||||||||||---||||||| 31 [O] COG0278 Glutaredoxin-related protein 7 11 14 25 -|--||----------|-|-|------||-|-----------||||||||||-||-|||---|--- 34 [G] COG0279 Phosphoheptose isomerase 9 15 23 46 --||-------------||-||--|||||-||||||||||||||||||||||||||-||||||||| 70 [C] COG0280 Phosphotransacetylase 9 19 29 47 --|||||||-|||||--|||-|----|||-|||-||||----|||||-||||||||--|||||||| 69 [C] COG0281 Malic enzyme 9 15 20 43 --|--------------|||||--|||||-||||||||||||||||||||||-||-|||-|||-|| 55 [C] COG0282 Acetate kinase 11 16 24 47 ---------------||||||||||||||||||||||||||||||||-||||||||---||||||| 48 [F] COG0283 Cytidylate kinase 11 24 33 55 |||||||||||||||-||||||----||||||||||||----||||||||||||||||||||||-- 56 [F] COG0284 Orotidine-5'-phosphate decarboxylase 11 18 26 48 ---|||-------||-||||||--|-||||||||||||----|||||||||||||||||||||||| 54 [H] COG0285 Folylpolyglutamate synthase 5 14 22 36 ||||---||----------|-------||--|||||--|||-|||-|-|||||||||||-||-|-| 68 [V] COG0286 Type I restriction-modification system methyltransferase subunit 10 22 31 50 ||||||--|||||||-||||-|----||||||-|||||----|||||-||||||||||||||||-- 51 [E] COG0287 Prephenate dehydrogenase 8 15 23 39 |--|------||-||---||-|----|||||-||--||----|||||-||||||||||||||||-- 57 [P] COG0288 Carbonic anhydrase 8 17 25 45 |||-----||------||||--||--|||-||-|||||----|||||||||||||||||||||||| 46 [E] COG0289 Dihydrodipicolinate reductase 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 51 [J] COG0290 Translation initiation factor 3 (IF-3) 11 17 25 51 -------------|--|||||||||||||||||||||||||||||||||||||||||||||||||| 51 [J] COG0291 Ribosomal protein L35 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [J] COG0292 Ribosomal protein L20 5 14 21 34 ||||||--||---|||--------||----------------||||||||||||||---||||||| 41 [J] COG0293 23S rRNA methylase 12 25 35 57 |||||||||||||||-||||||||--||||||||||||----|||||-||||||||||||||||-| 69 [H] COG0294 Dihydropteroate synthase and related enzymes 9 13 18 35 ---|------|-|||--|---|---|-||||||||||||||||||||-|-||-------||-||-- 37 [F] COG0295 Cytidine deaminase 11 14 18 28 --|--------|-|--|-||||||--|||----|--|-----|||||-||||---|---||-|--- 39 [G] COG0296 1,4-alpha-glucan branching enzyme 11 16 21 32 -|----||--||--|-||||||||------||-|--||----|||||-||||---|---||-|--- 38 [G] COG0297 Glycogen synthase 4 11 12 18 |||---||||--------||----------|-----------|||-|---|-----|||------- 22 [O] COG0298 Hydrogenase maturation factor 11 19 26 44 --||||----|--||-||||||----||||||||||||----|||||-||||||||--||||||-- 45 [F] COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN 9 14 17 27 --|----|---|-|||---||-----||||||||||||-----------|-|---|---||-||-- 40 [R] COG0300 Short-chain dehydrogenases of various substrate specificities 6 15 21 36 |||||||||||||----|------|-----|||||||||||||||||-||||-------------- 39 [H] COG0301 Thiamine biosynthesis ATP pyrophosphatase 9 15 23 41 ----------||-||-|-||||----||||||||-|||----|||||-|||||--||||||||||| 44 [H] COG0302 GTP cyclohydrolase I 8 20 26 44 |||||||||||||---|-||-|----|||||---||||----|||||-||||---|||||||||-- 70 [H] COG0303 Molybdopterin biosynthesis enzyme 10 16 24 46 -------------||-||||||||--||||||||||||----|||||||||||||||||||||||| 105 [IQ] COG0304 3-oxoacyl-(acyl-carrier-protein) synthase 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 63 [L] COG0305 Replicative DNA helicase 10 21 26 46 ||||||||||||-|---|-|-|||--|||||---||||----||||||||||-||||||||-|--- 71 [P] COG0306 Phosphate/sulphate permeases 11 17 24 43 ---|---------||-||||||||--||||||-||-||----||||||||||||||||||||||-- 43 [H] COG0307 Riboflavin synthase alpha chain 9 14 21 36 --|-||----||-|||--||-|----||||-|||--------|||||-||||||||---|||||-- 51 [E] COG0308 Aminopeptidase N 6 15 17 24 |||||||||||||---|-||----------|-----------|||-|---------|||------- 28 [O] COG0309 Hydrogenase maturation factor 4 12 13 13 ||||----||--------||----------|----|----------|---|----------|---- 24 [P] COG0310 ABC-type Co2+ transport system, permease component 8 17 20 29 |||||||||||||||--|---|----|||||--|||||------------||-------------- 31 [H] COG0311 Predicted glutamine amidotransferase involved in pyridoxine biosynthesis 9 19 27 40 |||-|||||||||---||||-|-----||-|------|----||||||||||||||---|||||-- 102 [R] COG0312 Predicted Zn-dependent proteases and their inactivated homologs 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 53 [R] COG0313 Predicted methyltransferases 8 18 24 41 |||||||||-|||---|-||-|----|||-----||||----|||||-||||---|||||||||-- 45 [H] COG0314 Molybdopterin converting factor, large subunit 8 20 26 43 |||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||-- 47 [H] COG0315 Molybdenum cofactor biosynthesis enzyme 8 12 19 35 --|----------||-|-||-|----||||----|-||----||||||||||||||---||||||| 80 [S] COG0316 Uncharacterized conserved protein 9 15 23 44 ----------------||||||---||||||||||||||-|||||||-||||||||||||||||-| 67 [TK] COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases 9 18 28 47 |-||||--|-|||||---||-|||--||||-||-||||----|||||-||||||||--|||||||| 257 [IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [R] COG0319 Predicted metal-dependent hydrolase 10 14 23 40 ---|------|||||-|-||-|||--||||----|-||----||||||||||||||---||||||| 43 [H] COG0320 Lipoate synthase 6 10 17 31 ----------|--||---||-|----||||------------||||||||||||||---||||||| 31 [H] COG0321 Lipoate-protein ligase B 11 19 27 52 |-||------------|||||||||||||||||||||||||||||||-|||||||||||||||||| 63 [L] COG0322 Nuclease subunit of the excinuclease complex 12 18 26 44 --||---------|||||||||||||----||||||||----||||||||||||||---||||||| 49 [L] COG0323 DNA mismatch repair enzyme (predicted ATPase) 11 17 25 48 -------------||-||||||||||||||||||||||----|||||||||||||||||||||||| 52 [J] COG0324 tRNA delta(2)-isopentenylpyrophosphate transferase 10 16 23 43 --|----------||-||||||----||||||||||||----||||||||||||||||||||||-- 44 [R] COG0325 Predicted enzyme with a TIM-barrel fold 8 14 19 35 -------------|||--|||---|||||||----|||----|||||||||||--||||-|-|-|| 37 [O] COG0326 Molecular chaperone, HSP90 family 11 22 27 47 ||||--||||---|||---|||||||||-|||||||||||--||||||||||-||||||------- 56 [S] COG0327 Uncharacterized conserved protein 9 14 21 39 ---|------|--||---||-|--|-||||----||||----|||||-|||||||||||||||||| 44 [L] COG0328 Ribonuclease HI 10 22 32 56 |||||||||||||---|||||-||--||||||||||||----|||||||||||||||||||||||| 114 [EM] COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase 12 26 36 57 |||||||||||||||-||||||--||||||||||---|-|--|||||||||||||||||||||||| 130 [O] COG0330 Membrane protease subunits, stomatin/prohibitin homologs 10 16 24 45 -------------||-||||||||--||||||||||||----|||||-|||||||||||||||||| 65 [I] COG0331 (acyl-carrier-protein) S-malonyltransferase 8 13 21 40 ----------------|-||||||---||-||||||||----|||||-|||||||||||||||||| 63 [I] COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III 10 17 25 48 -------------||-||||||||||----|||||||||||||||||||||||||||||||||||| 49 [J] COG0333 Ribosomal protein L32 11 21 28 42 --|||||||-|||||--|||||||--|---|--|||||----|||||--|||-|||||--||-|-- 66 [E] COG0334 Glutamate dehydrogenase/leucine dehydrogenase 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 52 [J] COG0335 Ribosomal protein L19 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [J] COG0336 tRNA-(guanine-N1)-methyltransferase 11 18 27 49 ----||-|--|||||--|||||||--||||||||||||----||||||||||||||||||||||-- 50 [E] COG0337 3-dehydroquinate synthetase 6 13 16 24 -|--|||-----------|||---|-----|----|-|----|||||-|-||||--||-------| 29 [L] COG0338 Site-specific DNA methylase 5 9 15 24 -------------||---||-|----|---------------|||||-||||||||---|||||-- 30 [E] COG0339 Zn-dependent oligopeptidases 13 24 32 54 ||||--|||--|-||-|||||||||-||||||||||||----|||||-|||||||||||||||||| 58 [H] COG0340 Biotin-(acetyl-CoA carboxylase) ligase 11 22 29 50 ||||--||-|------|||||||||||||||---||||-|--|||||-|||||||||||||||||| 52 [U] COG0341 Preprotein translocase subunit SecF 11 22 29 50 ||||--||-|------|||||||||||||||---||||-|--|||||-|||||||||||||||||| 55 [U] COG0342 Preprotein translocase subunit SecD 14 26 36 57 |||||||||||||-||||||||||-||---||||||||----|||||||||||||||||||||||| 61 [J] COG0343 Queuine/archaeosine tRNA-ribosyltransferase 7 13 19 38 ----------------||||||--------|||||||||||||||||-||||-|||||||||||-- 41 [S] COG0344 Predicted membrane protein 11 19 28 48 |-|-||----|||||-||||-|--|-||||||||||||----|||||-||||||||||||||||-- 56 [E] COG0345 Pyrroline-5-carboxylate reductase 9 19 27 45 |-||--|||--||||---||||----||||||||||||----|||||-||||||||--||||||-- 252 [E] COG0346 Lactoylglutathione lyase and related lyases 8 16 23 35 |||-----||------||||-|----|||-||---||-----|||||-||||||||---|||||-- 67 [E] COG0347 Nitrogen regulatory protein PII 5 13 18 29 -||-||--||-|------||----------|-----------|||-|-||||-|||||||||||-- 43 [C] COG0348 Polyferredoxin 5 7 13 25 -------------|----||------|||||-----------|||||-|||||------||||||| 33 [J] COG0349 Ribonuclease D 12 24 34 55 ||||||||||||||--||-||-|||-||||||-|||||-|--|||||-||||||||||||||||-| 83 [L] COG0350 Methylated DNA-protein cysteine methyltransferase 12 24 33 54 |||||||||||||||-||-|||--|-||||||||||||----|||||-||||||||||||||||-- 66 [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 9 18 25 45 --|-|||||----||-|-||||----||||||-|||||----|||||-||||||||||||||||-- 60 [H] COG0352 Thiamine monophosphate synthase 9 15 23 45 ----------------|-|||||||-||||||||||||||--|||||-|||||||||||||||||| 45 [L] COG0353 Recombinational DNA repair protein (RecF pathway) 6 10 17 31 -------------||-|-||-|----||||------------||||||||||||||---||||||| 31 [R] COG0354 Predicted aminomethyltransferase related to GcvT 9 16 24 48 --|----------||-|||||-----|||||||||||||||||||||||||||||||||||||||| 50 [C] COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) 9 15 23 47 --|----------|--|||||-----|||||||||||||||||||||||||||||||||||||||| 47 [C] COG0356 F0F1-type ATP synthase, subunit a 9 15 23 47 ----------------||||||--|||||||||||||||||||||||-|||||||||||||||||| 47 [M] COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division 12 25 35 63 |||||||||||||---|||||||||||||||||||||||||||||||||||||||||||||||||| 70 [L] COG0358 DNA primase (bacterial type) 11 17 25 51 --------------|-|||||||||||||||||||||||||||||||||||||||||||||||||| 51 [J] COG0359 Ribosomal protein L9 11 18 26 51 -------------||-|||||||||||||||||||||||||||||||||||||||||||-|||||| 51 [J] COG0360 Ribosomal protein S6 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 71 [J] COG0361 Translation initiation factor 1 (IF-1) 9 13 16 34 -------------|||-|||--||||||||-|-||||-----|||||||-||-||----||||--- 36 [G] COG0362 6-phosphogluconate dehydrogenase 10 17 24 44 -------------|||-||||-||||||||||||||||-|--|||||-||||||||||-|||||-- 61 [G] COG0363 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase 11 16 23 41 -------------|||||||-||||||||--|-||||-----||||||||||||||||-|||||-- 48 [G] COG0364 Glucose-6-phosphate 1-dehydrogenase 10 19 27 40 |-||||--|-|||||||-||-|-----||--|--||||----|||||-||-||--||-||||||-- 119 [I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases 9 16 20 34 --|-||----|--||--|||-|----|||-||||||||-|--|||||-||-----|---||-||-- 137 [G] COG0366 Glycosidases 7 17 22 34 |||||||||||-||||----------||||||---|||----|||||-||--|-------|-|--- 52 [E] COG0367 Asparagine synthase (glutamine-hydrolyzing) 8 19 23 34 |||||||||||||-----||||----|||-|----|-|----|||-|-||-----|---||||--- 35 [H] COG0368 Cobalamin-5-phosphate synthase 6 10 14 24 -------------|||--||--||----------|-||----||||||||--|||----|-|-|-- 34 [P] COG0369 Sulfite reductase, alpha subunit (flavoprotein) 8 18 22 30 |||---|||||-----||||-|--------||--||------|||||-||--|--||||----|-- 37 [P] COG0370 Fe2+ transport system protein B 7 17 20 30 |||||||||||||-|--|||----------||||-|||----|||||-------------|----- 37 [C] COG0371 Glycerol dehydrogenase and related enzymes 10 19 29 47 |-||||--|-|||||-||||-|----||||-|--||||----|||||-||-||||||||||||||| 80 [C] COG0372 Citrate synthase 10 20 27 42 ||||||--|||||---|-||||||--|||||---||||----|||||-||-||||||||------- 42 [H] COG0373 Glutamyl-tRNA reductase 5 8 8 13 --|-----||------|--|----------|-----------|||-|---------|||------- 21 [C] COG0374 Ni,Fe-hydrogenase I large subunit 5 12 12 18 |||---||||------|-||-|--------------------|||-|---------|||------- 24 [R] COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) 6 10 13 20 --||----|----|----|--------||--------|----|||||-|---|--|---||-||-- 21 [P] COG0376 Catalase (peroxidase I) 8 16 23 38 --|||||||-|||---||||-|-----||-------------||||||-|--|||||||||||||| 39 [C] COG0377 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases 9 18 20 32 |||-----||----|-|-||||----|||-----|--||---|||||--||----||||||||--- 47 [OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase 9 20 26 40 ||||--||||||----|||||-----|||||----|||----|||||-||--||||||-||-||-- 42 [H] COG0379 Quinolinate synthase 7 11 11 19 |---||----|--|||--|-------||||------------|||-|--------|----|-|--- 30 [G] COG0380 Trehalose-6-phosphate synthase 6 14 19 29 ||-|--||---------|||-|--------||-||||-----|||||-||-|-|||--|-----|| 36 [M] COG0381 UDP-N-acetylglucosamine 2-epimerase 10 23 32 49 |||||||||||||||-|-||-|||--|||||------|----|||||-||-||||||||||||||| 77 [H] COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases 8 11 12 16 -----||----|-||--|||-------||--|||-|-|----|----------------------- 22 [G] COG0383 Alpha-mannosidase 8 14 18 28 --||---------||---||||----|||-|----|||----|||-|-||-|---|---|||||-- 43 [R] COG0384 Predicted epimerase, PhzC/PhzF homolog 7 10 13 24 --|----------|--|-||------|--|----|-||----|||||--|---|||---|||||-- 36 [R] COG0385 Predicted Na+-dependent transporter 7 12 16 26 -------------|||--|-|-----|---|||||||||---|||||--|--||||-------|-- 36 [O] COG0386 Glutathione peroxidase 6 9 9 18 -------------||---||-|----||||------|-----|||||------------||-|--- 21 [P] COG0387 Ca2+/H+ antiporter 11 22 30 48 |-|||||||-|||||-||||-|--|-|||||--|||||----|||||-||--||||||||||||-- 126 [R] COG0388 Predicted amidohydrolase 8 15 21 39 --||-------|-||---|||-----|||-|||||||||||||||||-||-|-|||---|||||-- 76 [L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair 7 10 10 15 -||-------------||||-------||-----|-|-----|||-|--------|---------- 15 [R] COG0390 ABC-type uncharacterized transport system, permease component 9 16 19 31 ||||----||---|--||||-|----||||||||||||----|||||-|--|-------------- 34 [S] COG0391 Uncharacterized conserved protein 7 18 20 35 ||||--||||------||||------|||||---|||-|||||||-|--|--|--|---||||--- 61 [S] COG0392 Predicted integral membrane protein 7 15 18 26 |||||||||--|-----|||-------|||-|---|-|----|||-|-|--|-----------|-- 29 [S] COG0393 Uncharacterized conserved protein 8 17 24 38 |-||----|----||-|-||-|----|||-||||||||----|||-|-||-|||||--||||||-- 70 [T] COG0394 Protein-tyrosine-phosphatase 9 16 23 41 ---|||||--|||----|||-|--|-||||||||-|||-||||||||-||-||--|---||||--- 207 [G] COG0395 ABC-type sugar transport system, permease component 10 20 25 43 |||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||-- 46 [O] COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component 5 9 13 17 -------------||---||------|----------|----|||-|-||--|--|---||--|-- 18 [S] COG0397 Uncharacterized conserved protein 6 11 14 23 --||---------||---||------|||-||||||||----|||---|-----------|--|-- 38 [S] COG0398 Uncharacterized conserved protein 9 17 23 34 ||-----|-||-----||||----|-|||-|--|--|-----|||||-||-|-||||||-||||-- 68 [M] COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis 6 9 13 23 -------------||---||-|||-------|--||||----|||----|--|------||||-|| 30 [R] COG0400 Predicted esterase 3 6 7 10 -------------||---||----------------------|||-|--|---------|------ 15 [S] COG0401 Uncharacterized homolog of Blt101 10 23 30 42 |||||||||||||||-||||-|----|---|--|---|----|||||--||||--|||||||||-- 96 [FR] COG0402 Cytosine deaminase and related metal-dependent hydrolases 10 16 21 35 ---|||||---||||-||||-|-----|||----||||----|||||--|--|-||---|||||-- 36 [E] COG0403 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain 10 16 21 36 ---|||||---||||-||||-|-----|||----||||----|||||--|--||||---|||||-- 79 [E] COG0404 Glycine cleavage system T protein (aminomethyltransferase) 10 15 22 34 ----||----||||||--||||----|||-----|-||----|||-|-||--||||||-||-||-- 48 [E] COG0405 Gamma-glutamyltransferase 11 17 23 39 --|-||-----|-||-||||||----||||||||||||----|||||-||-||--|---|||||-- 132 [G] COG0406 Fructose-2,6-bisphosphatase 9 15 22 41 --|-||-------||-|-||-|||--||||----||||----|||||-||-||||||||||||||| 54 [H] COG0407 Uroporphyrinogen-III decarboxylase 3 7 12 20 -------------||---||----------------------|||||-||--|--|---||||||| 21 [H] COG0408 Coproporphyrinogen III oxidase 5 12 12 18 |||---||||------|-||----------|-----------|||-|---------|||------- 19 [O] COG0409 Hydrogenase maturation factor 9 14 18 25 -|------|-|||----|||||----|------|---|----|||||--|-----|--|||||--- 72 [E] COG0410 ABC-type branched-chain amino acid transport systems, ATPase component 8 13 16 23 -|------|-|||----|||||-----------|--------|||||--|-----|--|||||--- 60 [E] COG0411 ABC-type branched-chain amino acid transport systems, ATPase component 8 13 15 23 --|-|------|-||-|-||-------|||------|-----|||||--|-----|---||-||-- 50 [Q] COG0412 Dienelactone hydrolase and related enzymes 10 17 24 42 ---|--||--|||||-||||-|----|||||---||||----||||||||--||||||||||||-- 46 [H] COG0413 Ketopantoate hydroxymethyltransferase 8 14 19 36 -------------||-||||-|----|||||---||||----||||||||--||||||||||||-- 37 [H] COG0414 Panthothenate synthetase 7 12 16 23 |-||-------|-|----||------|-----|-||------||||||||----|----|--||-- 28 [L] COG0415 Deoxyribodipyrimidine photolyase 8 14 20 39 ----------------||||||||------|||||||||||||||||-||-|-|||||||||||-- 39 [I] COG0416 Fatty acid/phospholipid biosynthesis enzyme 6 14 18 24 ||||||||||||||||---|----------------------|||||-||---------------- 47 [L] COG0417 DNA polymerase elongation subunit (family B) 3 7 10 19 -------------||---|-----------------------||||||||---||||||||----- 19 [F] COG0418 Dihydroorotase 12 22 27 36 ||||||||||||||||||||||--||----||--|||-----|||||-||---------------- 41 [L] COG0419 ATPase involved in DNA repair 13 24 29 42 ||||||||||||||||||||||--||||||||--||||----|||||-||----------|----- 47 [L] COG0420 DNA repair exonuclease 9 18 24 34 -|--|||||||||||-||---|----|---|--|--||----||||||-|--||||||----|--- 41 [E] COG0421 Spermidine synthase 10 21 27 38 ||||---|||||----||||||----|||||-----||----|||||-||--||||--|||-||-- 42 [H] COG0422 Thiamine biosynthesis protein ThiC 8 18 20 29 ||||||||||||||||-----|--|||||||---|---||||------------------------ 30 [J] COG0423 Glycyl-tRNA synthetase (class II) 11 18 25 42 --|---||-----||-||||||||--|||||-----||----|||||-||-||||||||||||||| 57 [D] COG0424 Nucleotide-binding protein implicated in inhibition of septum formation 8 18 24 36 ||||||--||||----|||||-------------|-|-----||||||||||-|||--||||||-- 72 [O] COG0425 Predicted redox protein, regulator of disulfide bond formation 7 13 14 18 |||---|||-------|||||---------|-----------|||-|--|-----|---------- 39 [C] COG0426 Uncharacterized flavoproteins 6 9 11 16 ---|----|----||---|-|-----|---------------|||||--|---------|-|-|-- 19 [C] COG0427 Acetyl-CoA hydrolase 12 20 24 31 ||||--||--||||||||-|-|---||||------|------|||-|--|---|||--|-|----- 38 [P] COG0428 Predicted divalent heavy-metal cations transporter 4 6 9 14 -------------|-|--||----------------------|||||-||---|||---------- 16 [R] COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold 7 15 18 22 ||||--|||||||||||--|----------------------|||-|--|-----|---------- 22 [A] COG0430 RNA 3'-terminal phosphate cyclase 7 12 18 33 ---|---------||---||-|----|||--|||||||--|||||||-||-|-|||---||-||-- 59 [R] COG0431 Predicted flavoprotein 10 18 22 29 |||---|||||||-|-||||-|-----||-|-----||----|||-|-||---------||----- 36 [S] COG0432 Uncharacterized conserved protein 9 19 25 34 |||||||||||||---||||-|-----||---|----|----||||---|-|---|---|||||-- 71 [R] COG0433 Predicted ATPase 4 10 11 14 -|-|--|||||-|-----||----------------------|---|------------|--|--- 14 [R] COG0434 Predicted TIM-barrel enzyme 5 8 10 16 ---|---------||---||------|---------------|||-|-||---------||||--- 18 [O] COG0435 Predicted glutathione S-transferase 13 26 36 59 |||||||||||||||-|||||||||-||||||||||||----|||||-|||||||||||||||||| 193 [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase 4 10 15 21 --||---||-|||---|-------------------------|||||-||||---|--|-|-|--- 73 [C] COG0437 Fe-S-cluster-containing hydrogenase components 1 13 26 36 58 ||||||||||||||||||||||---|||||||||||||----|||||-|||||||||||||||||| 488 [M] COG0438 Glycosyltransferase 11 20 27 45 |||-----|--|-||-|-||-||||--||-||||||||----|||||-||||||||||||||||-- 71 [I] COG0439 Biotin carboxylase 10 21 27 45 |||---||||--|||-||||-|----||||||-|||||----||||||||||-|||--||||||-- 50 [E] COG0440 Acetolactate synthase, small (regulatory) subunit 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 75 [J] COG0441 Threonyl-tRNA synthetase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 68 [J] COG0442 Prolyl-tRNA synthetase 13 23 31 58 |-||||-------||||||||||||||||||||||||||||||||||||||||||||||||||||| 134 [O] COG0443 Molecular chaperone 11 20 26 47 --|||||||-|||---||--||||-||---|||||||||||||||||-||||---||||||||--- 163 [EP] COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component 10 17 25 48 -------------||-||||||||||----|||||||||||||||||||||||||||||||||||| 50 [D] COG0445 NAD/FAD-utilizing enzyme apparently involved in cell division 12 25 32 50 |||||||||||||||-||||||--|||||-||||||-|-||||||||-||-|---|---|||||-- 171 [R] COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases 5 7 10 20 ---|----|---------||------||||-|--|||-----|||||-|-||-------------- 20 [H] COG0447 Dihydroxynaphthoic acid synthase 8 11 14 27 -----------------|||||||--||||||-|--||----|||||-|-||-------||-|--- 36 [G] COG0448 ADP-glucose pyrophosphorylase 14 26 35 58 ||||||||-||||||||||||||||-||||||||||||----||||||||||||||||||||||-- 71 [M] COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains 14 24 33 53 |||-|||||-|||||||||||||||--|||-||-||||----||||||||-||--||||||||||| 72 [O] COG0450 Peroxiredoxin 12 25 33 53 ||||||||||||-||-||||||---|||||||-|||||----|||||-||||||||||||||||-- 289 [MG] COG0451 Nucleoside-diphosphate-sugar epimerases 12 25 34 55 |||||||||||||||-||||||---|||||||||||||----|||||-||||||||||||||||-- 66 [H] COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase 13 26 36 58 |||||||||-||||||||||||||--|||||||||||||---|||||-||||||||||||||||-| 542 [KR] COG0454 Histone acetyltransferase HPA2 and related acetyltransferases 8 16 17 24 ||-|--||||------||-|----||-||||-----||----------||-----||||------- 46 [D] COG0455 ATPases involved in chromosome partitioning 12 26 35 54 ||||||||||||||||||||||----|||||||||||||---|||||-||||||||--||||||-- 112 [R] COG0456 Acetyltransferases 13 25 33 53 |||||||||--|-|||||||||||||----||||||||----|||||-||-||||||||||||||| 510 [R] COG0457 FOG: TPR repeat 11 23 31 51 ||||||--||||-||-||||||----||||||||||||----||||||||-|||||||||||||-- 66 [EF] COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) 14 28 38 64 ||||||||||||||||||||||||||||||||||||||--|||||||||||||||||||||||||| 122 [O] COG0459 Chaperonin GroEL (HSP60 family) 10 23 32 53 |||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||-- 62 [E] COG0460 Homoserine dehydrogenase 12 25 34 56 |||||||||||||||-||||||-|--||||||||||||----||||||||||||||||||||||-- 59 [F] COG0461 Orotate phosphoribosyltransferase 12 26 36 62 |||||||||||||||-||||||--||||||||||||||||||||||||||||||||||||||||-| 76 [FE] COG0462 Phosphoribosylpyrophosphate synthetase 13 27 37 62 ||||||||||||||||||||||---||||||||||||||||||||||-|||||||||||||||||| 434 [M] COG0463 Glycosyltransferases involved in cell wall biogenesis 9 21 23 31 ||||||||||||||||--||-|----||||------||-----------|-----|--|||-|--- 107 [O] COG0464 ATPases of the AAA+ class 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 74 [O] COG0465 ATP-dependent Zn proteases 10 16 23 42 --|----------||-||--||||||----|-----|||||||||||||||||||||||||||||| 46 [O] COG0466 ATP-dependent Lon protease, bacterial type 7 15 17 21 ||||||||||||||--||||---------------------------------------||-|--- 70 [T] COG0467 RecA-superfamily ATPases implicated in signal transduction 14 28 38 65 |||||||||||||||||||||||||||||||||||||||||||||||-|||||||||||||||||| 87 [L] COG0468 RecA/RadA recombinase 13 24 33 57 -|||||||--||||||-|||||||-|||||||||||||||||||||||||||||||--||||||-- 71 [G] COG0469 Pyruvate kinase 14 27 37 64 |||||||||||||||||||||||||-||||-||||||||||||||||||||||||||||||||||| 108 [L] COG0470 ATPase involved in DNA replication 10 19 25 41 ||-|--||-||--||-|-|--|||--|---|||||-||----|||||-||||||||||||||---- 77 [P] COG0471 Di- and tricarboxylate transporters 13 22 30 54 ||----||-|||-||-||||||||||||||||||||||----|||||||||||||||||||||-|| 91 [M] COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase 10 21 30 48 |||---||||||-||-||||-|----||||||--||||----||||||||||||||--|||||||| 75 [CE] COG0473 Isocitrate/isopropylmalate dehydrogenase 9 17 19 35 |||-|--------||||-|||-----||||||||-||||||||||||--|----------|||--- 93 [P] COG0474 Cation transport ATPase 10 21 31 49 |||-|||||-|||||-|-||-|---|-|||||--||||----|||||-|||-|||||||||||||| 85 [P] COG0475 Kef-type K+ transport systems, membrane components 11 22 31 50 |-|||||||-|||||||-||||----|||||--|||||----|||||-||||||||||||||||-- 86 [H] COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 14 28 38 65 ||||||||||||||||||||||||||||||||||||||-||||||||||||||||||||||||||| 537 [GEPR] COG0477 Permeases of the major facilitator superfamily 4 10 12 13 -|||--||||||||||-------------------------------------------------- 14 [T] COG0478 RIO-like serine/threonine protein kinase fused to N-terminal HTH domain 10 20 29 48 ||-|||--|||||||-|-||-|||--||||----|-||----|||||-|||||||||||||||||| 62 [C] COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 97 [J] COG0480 Translation elongation factors (GTPases) 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 52 [M] COG0481 Membrane GTPase LepA 11 18 26 51 -------------||-||||||||-||||||||||||||||||||||||||||||||||||||||| 58 [J] COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain 11 21 31 50 ||||--||||||||--||||-|---|||||-|||||||----|-||||||||||||--|||||||| 92 [G] COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family 13 23 31 58 |-||||-------||||||||||||||||||||||||||||||||||||||||||||||||||||| 73 [O] COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain 10 17 25 48 -------------||-||||||||||----|||||||||||||||||||||||||||||||||||| 48 [R] COG0486 Predicted GTPase 10 17 25 48 -------------|||--||||||||||||||||||||-|--|||||||||||||||||||||||| 159 [R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains 12 25 35 55 ||||||||||||||||||||||----|||||--|||||----|||||-|||||||||||||||||| 104 [D] COG0489 ATPases involved in chromosome partitioning 5 6 7 10 --------|-------|----|-----||||||---|----------------------------- 11 [P] COG0490 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels 12 25 34 56 ||||||||||||||||||||||----||||||||||||----||||||||||||||||||||||-- 271 [R] COG0491 Zn-dependent hydrolases, including glyoxylases 14 27 37 65 ||||||||||||||-||||||||||||||||||||||||||||||||||||||||||||||||||| 121 [O] COG0492 Thioredoxin reductase 12 19 26 42 --|-||||--|-|||||||--|--|-||||||--||||----|||||-||--|--|--|||||||| 77 [ER] COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases 14 24 34 57 |-||||--|-|||||||||||||||-||||||||||||----|||||||||||||||||||||||| 335 [LR] COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 70 [J] COG0495 Leucyl-tRNA synthetase 10 19 26 38 ||||----|||-||--||||-||||-----------------|||||-||||||||||||||||-- 41 [R] COG0496 Predicted acid phosphatase 8 13 21 41 ----------------|-||||--|-||||||||||||----|||||-|||||||||||||||||| 41 [L] COG0497 ATPase involved in DNA repair 10 23 32 53 |||||||||||||||-||||-|----||||||-|||||----||||||||||||||||||||||-- 70 [E] COG0498 Threonine synthase 8 19 23 31 |||||||||||||||-||||------||||-------------------|--|--|---|||||-- 32 [H] COG0499 S-adenosylhomocysteine hydrolase 14 27 37 61 |||||||||||||||||||||||||-||||||||||||----|||||||||||||||||||||||| 786 [QR] COG0500 SAM-dependent methyltransferases 11 24 33 53 |||||||||||||||||-||||----|||||-||-|||----||||||||||||||||||||||-- 110 [O] COG0501 Zn-dependent protease with chaperone function 10 19 25 41 |||------|---||-|||||--|--|||||---|-||----||||||||||||||||||-|||-- 49 [H] COG0502 Biotin synthase and related enzymes 11 23 30 54 ||||--||-||||||--|||||--|||||-||||||||||||||||||||||-||||||||||--- 93 [F] COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins 13 27 37 63 ||||||||||||||||||||-|||||||||||||||||||--|||||||||||||||||||||||| 67 [F] COG0504 CTP synthase (UTP-ammonia lyase) 11 23 31 51 ||||||--||||-||-||||||----||||||||||||----||||||||-|||||||||||||-- 55 [EF] COG0505 Carbamoylphosphate synthase small subunit 7 12 16 30 ---|---------||---||-|----|||-----|-||----|||||--|-|-|||||||||||-- 32 [E] COG0506 Proline dehydrogenase 9 15 20 37 -|-----------||----|-|||-|-||-||||||||-|--|||||||||||||---|||||--- 52 [L] COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member 9 15 25 48 ---|||----|||||---||-|||--||||-|||||||-|||||||||||||||||---||||||| 122 [C] COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes 11 18 25 41 ---|||||---||||-||||-|||---|||--|-||||-|--|||||-||--||||---|||||-- 50 [E] COG0509 Glycine cleavage system H protein (lipoate-binding) 5 8 11 22 -------------||-----|---|------|||||||-||||||||-|-|-----------|--- 27 [M] COG0510 Predicted choline kinase involved in LPS biosynthesis 13 23 30 51 |||---|||--|-||-|||||||||-||||||||||||----|||||-||||||||||||||||-- 78 [I] COG0511 Biotin carboxyl carrier protein 11 24 33 54 ||||||-||||||||-||||||----||||||||||||----||||||||||||||||||||||-- 79 [EH] COG0512 Anthranilate/para-aminobenzoate synthases component II 12 23 31 55 |||-||--|--|-||||-||||--|-||||||||||||||||||||||||||||||||-||||||| 218 [LKJ] COG0513 Superfamily II DNA and RNA helicases 11 16 23 34 --|---------||||--||||--|-|---||--||||----|||||-||||||||---||-||-- 46 [L] COG0514 Superfamily II DNA helicase 11 19 25 41 ---|||----||-||||-||-|||--||||||||||||||||-|-|--|||||--||--|--|--- 407 [RTKL] COG0515 Serine/threonine protein kinase 13 24 31 53 ||-|||||-|--|||-||||||-|-|||||||||||||----||||||||||||||||||||||-- 138 [F] COG0516 IMP dehydrogenase/GMP reductase 13 26 36 59 |||||||||||||||-||||||||-|||||||||||||----|||||-|||||||||||||||||| 330 [R] COG0517 FOG: CBS domain 13 26 35 56 |||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||-- 83 [F] COG0518 GMP synthase - Glutamine amidotransferase domain 13 26 35 56 |||||||||||||||-||||||-|-|||||||||||||----|||||-||||||||||||||||-- 56 [F] COG0519 GMP synthase, PP-ATPase domain/subunit 12 22 29 53 |-||--||-|-||-|--||||||||||||||||||||||||||||||-|||||--|||||||||-- 89 [E] COG0520 Selenocysteine lyase 8 19 25 43 |||||||||||||---|--|-|----|||||---||||----|||||-||||---|||||||||-- 54 [H] COG0521 Molybdopterin biosynthesis enzymes 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 76 [J] COG0522 Ribosomal protein S4 and related proteins 9 14 19 32 --|----------||-|-||||----|||-----|-||----|||||-||--||||||-|||||-- 67 [R] COG0523 Putative GTPases (G3E family) 9 21 29 47 |||||||||||||||--|||-|----||||||||||||----|||||-|||||--|---|||||-- 202 [G] COG0524 Sugar kinases, ribokinase family 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 68 [J] COG0525 Valyl-tRNA synthetase 14 27 37 65 |||||||||-|||||||||||||||||||||||||||||||||||||||||||||||||||||||| 357 [OC] COG0526 Thiol-disulfide isomerase and thioredoxins 11 24 34 56 |||||-|||||||||-||||-|||--||||||-|||||----|||||||||||||||||||||||| 85 [E] COG0527 Aspartokinases 12 25 35 63 |||||||||||||---|||||||||||||||||||||||||||||||||||||||||||||||||| 63 [F] COG0528 Uridylate kinase 9 15 19 28 -------||---|||-|-|--|-----||-|-----||----||||||||--|--|--|-||||-- 33 [P] COG0529 Adenylylsulfate kinase and related kinases 9 18 21 28 ||||||||||||-||-|||-----||-----------|----|||||-|--|--------|----- 37 [P] COG0530 Ca2+/Na+ antiporter 10 22 31 53 ||||||--||||||||--|||-||--|||||||||||||||||||||-|||||--|---||||||| 257 [E] COG0531 Amino acid transporters 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 72 [J] COG0532 Translation initiation factor 2 (IF-2; GTPase) 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 68 [O] COG0533 Metal-dependent proteases with possible chaperone activity 12 23 30 53 ||||--|||---|||-|||-||--|||||-|||||||||||||||||-||||||||||||||||-- 140 [V] COG0534 Na+-driven multidrug efflux pump 9 20 23 29 |||||||||||||---||||-|-----||-||--|-||-----------|-----|----|-|--- 98 [R] COG0535 Predicted Fe-S oxidoreductases 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 52 [R] COG0536 Predicted GTPase 13 26 36 63 |||||||||-|||||||-||||||-||||||||||||||||||||||||||||||||||||||||| 108 [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases 10 17 23 36 ---|||--|-|||||-||||-|-----||--|--||||----|||||--|-|---|||-|||||-- 38 [C] COG0538 Isocitrate dehydrogenases 11 18 26 49 -------------||-||||||||||||||||||||||-|--|||||||||||||||||||||||| 52 [J] COG0539 Ribosomal protein S1 11 24 32 53 |||||||||||||||-||||||----||||||||||||----||||||||--||||||||||||-- 53 [F] COG0540 Aspartate carbamoyltransferase, catalytic chain 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 66 [U] COG0541 Signal recognition particle GTPase 13 20 28 52 |------------||||||||||||||||||||||||||-|||||||-|||||||||||||||||| 128 [O] COG0542 ATPases with chaperone activity, ATP-binding subunit 10 20 25 38 |||-||||||-|-||-||--|---|-|||-||-|-|||----|||||-||---|||---|----|| 67 [HC] COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 51 [O] COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) 7 11 16 24 -------------||---||-||||-|---------------||||||||||||||-------|-- 45 [O] COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1 9 19 26 46 |-||--|||----|--|-||-|--|||||-|||||||||---|||||-||||||||||||||||-- 91 [R] COG0546 Predicted phosphatases 10 23 32 52 ||||||-||||||||-||||-|----||||||-|||||----||||||||||||||||||||||-- 66 [E] COG0547 Anthranilate phosphoribosyltransferase 10 21 31 47 |||---|||||||||-||||-|----||||||--||||----||||||||-|||||--||||||-| 60 [E] COG0548 Acetylglutamate kinase 5 9 13 20 ---|||||--|-|-----|------------||||-----|-|||-|--||---------|----- 30 [E] COG0549 Carbamate kinase 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 90 [L] COG0550 Topoisomerase IA 7 17 23 42 |||||||||--------|--|-|||-----|||||||||-|||||||||||||||||||------- 57 [L] COG0551 Zn-finger domain associated with topoisomerase type I 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 66 [U] COG0552 Signal recognition particle GTPase 12 21 27 41 --||-||||--|||||-|||||||--|||-||||-|||--|||||||-|||||-------|----- 109 [KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family 12 20 27 46 ---|||-||--|||--||||||---|||||||||||||-||||||||-|||||--|---|||||-- 52 [C] COG0554 Glycerol kinase 7 18 25 37 ||||||||||||------||-|-----||-|------|----|||||-||||||||---|||||-- 42 [O] COG0555 ABC-type sulfate transport system, permease component 11 19 27 52 |-||------------|||||||||||||||||||||||||||||||-|||||||||||||||||| 53 [L] COG0556 Helicase subunit of the DNA excision repair complex 13 20 27 48 ---|---------||||||||||||-|---||||||||||||||||||||||||||||||||||-- 62 [K] COG0557 Exoribonuclease R 13 25 35 62 |-|||||||-|||||||||||-|||||||||||||||||||||||||-|||||||||||||||||| 104 [I] COG0558 Phosphatidylglycerophosphate synthase 9 14 18 25 -|------|-|||----|||||----|------|---|----|||||--|-----|--|||||--- 73 [E] COG0559 Branched-chain amino acid ABC-type transport system, permease components 8 20 27 43 |||||||||||-|||-----|--|--||||||----------|||||-||||||||||||||||-- 76 [E] COG0560 Phosphoserine phosphatase 13 25 31 55 |-||||||||||||||-||||||||||||||||||||||||||||||||-||-|||---||-|--- 171 [R] COG0561 Predicted hydrolases of the HAD superfamily 5 8 8 13 |--------------------|----|||||---------|||---|-----------||------ 13 [M] COG0562 UDP-galactopyranose mutase 13 23 31 58 --||--|||----||||||||||||||||||||||||||||||||||||||||||||||||||||| 85 [F] COG0563 Adenylate kinase and related kinases 12 19 27 53 -------------||||||||||||||||||||||||||||||||||||||||||||||||||||| 146 [J] COG0564 Pseudouridylate synthases, 23S RNA-specific 5 14 22 32 ||||||--||-||-----||-|--------------------|||||-||||||||---|||||-| 36 [J] COG0565 rRNA methylase 12 19 27 52 --------|----||-|||||||||||||||||||||||||||||||-|||||||||||||||||| 109 [J] COG0566 rRNA methylases 6 9 16 33 -------------||------|||--||||----|-||----||||||||||||||---||||||| 38 [C] COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 103 [K] COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) 11 22 27 44 ||||--|||||-|---||||||--||-||---||||||-||||||||-||||-||---||||---- 70 [P] COG0569 K+ transport systems, NAD-binding component 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 57 [K] COG0571 dsRNA-specific ribonuclease 9 13 16 29 ---|---------||--|||-|-|||----|||||||||-|||||||-|-||-------------- 35 [F] COG0572 Uridine kinase 10 22 29 47 ||||---||||||---||||-|---||||||||||||||-|||||||-|-|||--|--||||||-- 54 [P] COG0573 ABC-type phosphate transport system, permease component 11 23 32 49 |||||||||||||---||||||--|-|||||--|-||-----|||||-||--|||||||||||||| 73 [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase 14 28 38 65 |||||||||||||||||||||||||||||||||||||||||||||||-|||||||||||||||||| 66 [I] COG0575 CDP-diglyceride synthetase 12 22 30 57 |-||||-------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 60 [O] COG0576 Molecular chaperone GrpE (heat shock protein) 11 21 28 44 ||||----||||-----||||||||-|||-||||||||----|||||-||-|-|||--||||||-- 169 [V] COG0577 ABC-type antimicrobial peptide transport system, permease component 10 14 19 36 ---|||-----|-|||--|--|---|||||-|||||||----|||||-|||||--|---||||--- 53 [C] COG0578 Glycerol-3-phosphate dehydrogenase 8 16 21 35 ----|--||---|----||||-----|||-|---|--|-||||||-|-||--||||||||||||-- 44 [R] COG0579 Predicted dehydrogenase 11 17 22 38 |-------|--|-|||-||-||---|----||||||||-|||||||||-||||--|---|||||-- 60 [G] COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) 10 22 30 48 ||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||-- 57 [P] COG0581 ABC-type phosphate transport system, permease component 11 23 32 56 |||||||||--||---||||||||--||||||||||||||--|||||-|||||||||||||||||| 371 [L] COG0582 Integrase 8 16 23 40 ||------||------|-||||----||||||||||||----|||||-||||||||--||||||-- 904 [K] COG0583 Transcriptional regulator 12 19 25 44 ---|||-|--|-||||-|-|||--|-||||||||||||-||||||||-||||---|---|||||-- 93 [C] COG0584 Glycerophosphoryl diester phosphodiesterase 7 16 21 30 |||||||||||||||||----|--------------------|||||-||||----|||------- 31 [S] COG0585 Uncharacterized conserved protein 8 13 20 38 ----||-----|------||-|--||||||||--||||----|||||||||||||||||--|||-- 89 [S] COG0586 Uncharacterized membrane-associated protein 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 67 [L] COG0587 DNA polymerase III, alpha subunit 8 12 17 34 --|----------||-----|-||||||||||||||------||||||--||||||----||||-- 37 [G] COG0588 Phosphoglycerate mutase 1 9 19 28 48 |||||||||||||-|-|-||-|----||||-|||||||----|||||-||||-|||---||||||| 207 [T] COG0589 Universal stress protein UspA and related nucleotide-binding proteins 10 15 23 42 --|----------||||-||-|||--||||||-|||||----||||||||||||||---||||||| 65 [FJ] COG0590 Cytosine/adenosine deaminases 9 18 25 41 |-|||||||--||||---|-|--|--|------||-||----|||||-||||-||||||||||-|| 70 [ER] COG0591 Na+/proline symporter 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 74 [L] COG0592 DNA polymerase sliding clamp subunit (PCNA homolog) 9 15 23 49 ----------------||||-||||||||||||||||||||||||||||||||||||||||||||| 73 [L] COG0593 ATPase involved in DNA replication initiation 9 15 23 48 -----------------||||||||||||||||||||||||||||||||||||||||||-|||||| 48 [J] COG0594 RNase P protein component 8 17 20 38 ||||--||-|-------|||||----||||||||||||||||--------------|||||||||| 55 [R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily 12 22 32 55 --||||--|-|||||||-||||---|||||||-||||||||||||||-|||||||||||||||||| 481 [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [MU] COG0597 Lipoprotein signal peptidase 11 20 28 45 -||---|-|-||-||-||||||----|||||||||||-----|||||-|||||--|||||||||-| 78 [P] COG0598 Mg2+ and Co2+ transporters 9 17 23 32 |||-||--||-|-||--||--|----|||--|---|||-------|---||-||||---|||||-- 64 [S] COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit 9 16 20 30 -||-----||-------|||||||--|---|--||-||----||||---|||---|---|||||-- 92 [P] COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component 12 22 28 52 --|||||||-|||---||||||||-||||||||||||||||||||||-||||---||||||||--- 244 [EP] COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components 7 19 28 47 ||||||||||||----|-|||---------||||||||----|||||-|||||||||||||||||| 61 [O] COG0602 Organic radical activating enzymes 6 18 27 43 |||||||||||||---|-||----------|---|-||----|||||-|||||||||||||||||| 47 [R] COG0603 Predicted PP-loop superfamily ATPase 9 14 21 35 --||||----||-||-|--|-|----||||-|--||||----|||||-||-||--|---|||||-- 139 [CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases 12 21 31 54 |-||||----|||||||-||-|||-|||||||||||||----|||||||||||||||||||||||| 74 [P] COG0605 Superoxide dismutase 10 15 22 35 |--------|------||||||---||||-|-----------|||||-||||||||||||||||-| 40 [O] COG0606 Predicted ATPase with chaperone activity 12 22 31 52 |-||||--|-||-||||-||||---|||||||||||||----|||||||||||||||||||-|||| 168 [P] COG0607 Rhodanese-related sulfurtransferase 12 24 33 54 ||||||||||||----|||||||||||---||||||||----|||||-|||||||||||||||||| 76 [L] COG0608 Single-stranded DNA-specific exonuclease 9 20 27 44 -||||||||-|||----|||||----|---|||||||||---|||||-||||---|||||||||-- 164 [P] COG0609 ABC-type Fe3+-siderophore transport system, permease component 4 13 19 27 ||||---||----------|-----------||-||--|||-------||||||--|||-||-|-| 44 [V] COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases 7 18 25 38 |||||||||||||---|-||------||||------||----||||||||||||||--|----|-- 38 [H] COG0611 Thiamine monophosphate kinase 11 17 25 43 ----------|-|||-||||||---|-|||||||||||----|||||-|||||--||||||||||| 91 [R] COG0612 Predicted Zn-dependent peptidases 8 15 20 26 ||||----|--||---||||-|--------|------|----|||||-||||-|||---------- 34 [R] COG0613 Predicted metal-dependent phosphoesterases (PHP family) 9 19 26 46 -||||||||-|||----|||||----||||||||||||----|||||-||||---|||||||||-- 181 [P] COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component 7 15 18 22 |||||||||||||||||--------------|--|||----------------------------| 26 [MI] COG0615 Cytidylyltransferase 12 22 30 51 |||||||||-|-|---|||||||||-||||-----|||----|||||||||||||||||||||||| 89 [OU] COG0616 Periplasmic serine proteases (ClpP class) 12 18 26 49 -------------|||||||||||||||||||||||||----|||||||||||||||||||||||| 75 [J] COG0617 tRNA nucleotidyltransferase/poly(A) polymerase 11 19 21 33 -|||--|||||-|---||||||--|||||-||||||||||||------|----------------- 48 [R] COG0618 Exopolyphosphatase-related proteins 9 19 22 38 ||||--||||-||----|||||----||||||||||||||||-||-|---|--------|||---- 70 [P] COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters 9 20 29 46 |||||||||||||||-||-----|--||||-|-|||||----||||||||||||||--||--||-- 60 [E] COG0620 Methionine synthase II (cobalamin-independent) 12 24 33 53 |||||||||||||---||||||-||-|||||---|-||----|||||||||||||||||||||||| 90 [J] COG0621 2-methylthioadenine synthetase 9 18 23 35 ||||--|||||||||--|--|---|----|||||||||-||||||||-||---------------- 48 [R] COG0622 Predicted phosphoesterase 7 11 17 35 ----------------|-||-|||---|||-|--||||----|||-||-|||-||||||||||||| 39 [I] COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH) 11 20 30 53 -|--|||||||||||-||--||-|--||||||||||||----|||||||||||||||||||||||| 157 [E] COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases 4 8 15 26 -------------||---||------------||--------|||||-||||||||---||||||| 194 [O] COG0625 Glutathione S-transferase 9 17 26 47 --||||||--|||||--|--||----||||||||||||----|||||-||||||||||||||||-- 107 [E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases 5 8 13 28 -------------|----||------||||-|||||------|||||--|||-|||---|||||-- 52 [R] COG0627 Predicted esterase 10 20 28 50 ||||--|||-------||||||--|||||-||||||||----|||||||||||||||||||||||| 128 [R] COG0628 Predicted permease 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 82 [L] COG0629 Single-stranded DNA-binding protein 3 10 14 21 -||||||||-|||---------------------------------------|---||-||||||| 52 [NU] COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis 9 16 18 31 -----|-------||-|-||-|||--||||||||||||||||-------|--|--||--|--|--- 55 [T] COG0631 Serine/threonine protein phosphatase 9 15 23 48 -----------------||||||||||||||||||||||||||||||-|||||||||||||||||| 48 [L] COG0632 Holliday junction resolvasome, DNA-binding subunit 9 13 19 31 ---|---------||||-||-|||--|---------------||||||||||-|||---||||||| 69 [C] COG0633 Ferredoxin 7 11 18 38 ----------------||--||----||||||-|||||||||||||||||||||||---|||||-- 39 [F] COG0634 Hypoxanthine-guanine phosphoribosyltransferase 10 16 24 46 ----------------|||||||||||||-|||||||||---|||||||||||||||||||||||| 85 [H] COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases 14 28 37 65 ||||||||||-||||||||||||||||||||||||||||||||||||||||||||||||||||||| 77 [C] COG0636 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K 10 18 26 44 --|-|||---||-||--|||-|||--|||||||-||||-|--|||||-||||||||---|||||-- 109 [R] COG0637 Predicted phosphatase/phosphohexomutase 5 13 15 19 ||||||||||||||||-----------|||------------------------------------ 79 [O] COG0638 20S proteasome, alpha and beta subunits 10 22 31 45 -|||||||||||||||-|||||--------||-|-|||----||||||||||||||--|||-||-- 112 [T] COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases 10 22 31 48 |||||||||||||---||||||----|||||||-||||----|||||-||-|||||--||||||-- 281 [K] COG0640 Predicted transcriptional regulators 6 11 12 17 |||-----|--|-----|||----------|-----------|||||---||--------|----- 37 [R] COG0641 Arylsulfatase regulator (Fe-S oxidoreductase) 12 21 29 50 |-||----|----||-||||||||-|||||||||||||----|||||-|||||||||||||||||| 798 [T] COG0642 Signal transduction histidine kinase 7 15 19 31 --||--|||--------|||-|--||----|----|||----|||||-||--|--||||||-||-- 46 [NT] COG0643 Chemotaxis protein histidine kinase and related kinases 10 21 27 39 |||||||||||||||-|||||-----|||||-----------|||-|--|--||||---|||||-- 98 [C] COG0644 Dehydrogenases (flavoproteins) 6 8 9 11 ---|------------|-||-|-----||--------------------|----------|-||-- 13 [R] COG0645 Predicted kinase 7 11 14 27 -----------------|||||----|||||---||||----|||||-||-----|---|||||-- 30 [E] COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain 9 14 19 35 ---|--|||--||||-||--|-----|||--|||||||----|||||--|--------|||||||| 46 [G] COG0647 Predicted sugar phosphatases of the HAD superfamily 10 18 21 37 ||||||||--||||||||----||---||||---|||||||||||||||----------------- 39 [L] COG0648 Endonuclease IV 8 16 23 38 --|||||||-|||---||||-|-----||-------------||||||-|--|||||||||||||| 41 [C] COG0649 NADH:ubiquinone oxidoreductase 49 kD subunit 7 5 10 10 15 |||--|||-|-|-----|---------||-------------|||-|------------------- 23 [C] COG0650 Formate hydrogenlyase subunit 4 8 16 21 33 ||||-||||-|||----|||-|----|||-----||||----|||-|-||---------|||--|| 69 [CP] COG0651 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit 10 18 25 44 |-||---------|||--||||--|-||||||||||||----|||||-||||||||||||||||-- 91 [O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 61 [U] COG0653 Preprotein translocase subunit SecA (ATPase, RNA helicase) 6 10 17 30 -------------||---||-|----|||-----|-||----|||||-||-|||||---||||||| 109 [HC] COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases 9 17 23 33 |||-----||-|-||-|---||-----||||--|||||----||-||-||--|--|---|||-|-| 82 [R] COG0655 Multimeric flavodoxin WrbA 9 15 20 37 ---|||||--||||||-||-------||||||||||||----|||||--|-----|---|||||-- 96 [R] COG0656 Aldo/keto reductases, related to diketogulonate reductase 10 17 22 34 --|--|--|--|-||--|||-|--|-|||||||-||-|----|||||-||--|--|---||-||-- 105 [I] COG0657 Esterase/lipase 10 16 24 47 ----------------|||||||||||||-|||||||||||||||||-||||||||||||||||-| 47 [R] COG0658 Predicted membrane metal-binding protein 9 14 18 30 --|----------||||-||--||--||||-|---|||----|||-|-||-|---|||-||-|--- 60 [P] COG0659 Sulfate permease and related transporters (MFS superfamily) 7 15 22 34 |-||||-----|-||---||-------||||------|----|||||-||-|||||---||||||| 52 [R] COG0661 Predicted unusual protein kinase 8 17 22 34 |||---||||------|||||------||-------||----|||||-||--||||||-|||||-- 63 [G] COG0662 Mannose-6-phosphate isomerase 8 18 24 37 |||-||||-|-|----|-||-|----|||-|-----||----|||-|-||--||||--|||||||| 54 [R] COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily 12 18 25 42 -------------||||||||||||-|||||||-||||----|||||-||||||||--||||||-- 178 [T] COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases 11 21 30 51 --|||||||-|||||-|-||-|||-|||||||||-|||----|||||-||||||||||||||||-- 225 [E] COG0665 Glycine/D-amino acid oxidases (deaminating) 11 16 23 32 ----||----|--|||--||||--|||---|-----------||||--||-|||||--|||-|||| 96 [R] COG0666 FOG: Ankyrin repeat 12 18 25 38 ---|||----|||||-||||||---|||||-|--||||----|||||-||--|--||--||-||-- 153 [C] COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) 13 25 34 56 |||||||||||||-||||||||--|||||-||||||||----||||||||--|||||||||||||| 141 [M] COG0668 Small-conductance mechanosensitive channel 9 15 22 43 ----------------||||||--||||||||||||||-|--||||||||||||||||||||||-- 43 [H] COG0669 Phosphopantetheine adenylyltransferase 8 15 22 39 -------------||---||||||-|----|||||||--|--|||||-||||-||||||||||||| 51 [R] COG0670 Integral membrane protein, interacts with FtsH 12 23 30 49 ||||--||-|-|-||||-||||--|-||||||||||||----|||||-|||||--|||-||||||| 120 [I] COG0671 Membrane-associated phospholipid phosphatase 9 14 17 24 --------|---|||--||||---|---------|||-----||||---|-|-||---|--|--|| 26 [P] COG0672 High-affinity Fe2+/Pb2+ permease 10 21 27 43 |-||||||-|||-||-||||-|----|---||||||||----|||||-||-|---|||||||||-- 229 [R] COG0673 Predicted dehydrogenases and related proteins 11 22 26 37 |||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||------- 81 [C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit 9 16 18 25 -|||||||-|||----||||-|---|-||-------------|||-|-----|---||-------- 189 [L] COG0675 Transposase and inactivated derivatives 3 3 7 12 -------------|------------|---------------|||||-|||||------------- 14 [G] COG0676 Uncharacterized enzymes related to aldose 1-epimerase 5 10 14 21 ||----||--|------|------------|---|-------|||||-||-||--|---||-|--- 24 [M] COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase 3 7 11 16 -------------||---||-------------------------|--|-||-|||---|||||-- 20 [O] COG0678 Peroxiredoxin 9 17 24 34 ||-------|---||-|||||-----|---||--||||----||||--||-||--|--|||||||| 50 [R] COG0679 Predicted permeases 6 13 13 19 |||---||||-|----|-||----------|-----------|||-|---------|||------- 37 [C] COG0680 Ni,Fe-hydrogenase maturation factor 14 28 38 63 ||||||||||||||||||||||||||||||||||||||-|--|||||||||||||||||||||||| 93 [U] COG0681 Signal peptidase I 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [M] COG0682 Prolipoprotein diacylglyceryltransferase 9 15 19 26 -|-|----|-|||----|||||----|------|---|----|||||--|-----|--|||||--- 112 [E] COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component 6 12 15 25 |||-----||---|-------|----||||-------|----|||||-||||---|---||-|--- 34 [H] COG0684 Demethylmenaquinone methyltransferase 10 18 27 43 --|-||||--|||||-||||-|----|---||-|||||----||||||||||||||--||||||-- 51 [E] COG0685 5,10-methylenetetrahydrofolate reductase 5 8 10 17 ------------------||-|-----|||-|--||||----------|-------||--|-||-- 20 [E] COG0686 Alanine dehydrogenase 9 15 22 38 ---|----|-|-|----|||||--||----||||||--|||||||||-||||-|||---|||||-- 114 [E] COG0687 Spermidine/putrescine-binding periplasmic protein 8 18 24 40 ||||----||---||-----||||---||||-----||----|||||-|||||||||||||||-|| 45 [I] COG0688 Phosphatidylserine decarboxylase 11 18 27 44 |---|||||||||||||--|||----||||-----|||----|||||-||||||||---||||||| 49 [J] COG0689 RNase PH 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [U] COG0690 Preprotein translocase subunit SecE 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [O] COG0691 tmRNA-binding protein 9 14 20 42 -------------|||----||||-|||||-||||||||||||||||||||||||||||||----- 43 [L] COG0692 Uracil DNA glycosylase 11 24 32 48 -||||||||||||||-|-||||--||-||-|--|||||-||||||||-||-||--|--||||||-- 110 [R] COG0693 Putative intracellular protease/amidase 6 11 17 33 ---|----|----||---||--||----------||||----|||||||||||---|||||||||| 39 [O] COG0694 Thioredoxin-like proteins and domains 9 17 25 42 |-||----|----|||-|||-|----|||||||||||-----|||||-||||||||---||||||| 82 [O] COG0695 Glutaredoxin and related proteins 5 11 13 25 --||-----------|--||----------|---|||||||||||||-||------||||------ 27 [G] COG0696 Phosphoglyceromutase 14 25 35 57 |-|||||||-|||||||||||||||-|||-||-|||||----|||||||||||||||||||||||| 386 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily 7 11 14 31 ----------------|||-|-----|||||-|||||||||||--||----|----|||-|||-|| 47 [G] COG0698 Ribose 5-phosphate isomerase RpiB 7 11 12 19 -------------|||--||-|-----||-----|-||----|||----|-----||||------- 44 [R] COG0699 Predicted GTPases (dynamin-related) 3 5 7 11 ------------------|-----------|-----||----|||-|-||-----|---------- 11 [S] COG0700 Uncharacterized membrane protein 7 14 15 21 |||-----||------||||-------||-|-||-|||----|||-------------|------- 26 [R] COG0701 Predicted permeases 8 12 18 28 ---|---------||-|-||-|----|----|--||||----|||||-|||-|--|---|||||-- 102 [MG] COG0702 Predicted nucleoside-diphosphate-sugar epimerases 11 17 24 45 --|----------||-||||||||--||||||||||||----||||||||||||||||||||||-- 52 [E] COG0703 Shikimate kinase 10 22 29 47 |||||||||||||---||||-|---|||||||||||-||-|||||||-||--|--|---|||||-- 82 [P] COG0704 Phosphate uptake regulator 11 23 31 48 -||||-|||||||||-||||-|--|-||||||||||||----|||||-|||||--|--||||||-- 69 [R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid) 11 18 26 52 -------------||-|||||||||||||||||||||||||||||||||||||||||||||||||| 62 [U] COG0706 Preprotein translocase subunit YidC 12 18 26 49 --|------|-|----||||||||||||||||||||||----|||||||||||||||||||||||| 56 [M] COG0707 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase 11 20 28 47 |-|-||--|--|-|||--||||--|||||-||||-||-----|||||-|||||||||||||||||| 65 [L] COG0708 Exonuclease III 4 7 10 15 -|-------|||----|-------------------------|||||--|||------|-|----- 15 [E] COG0709 Selenophosphate synthase 7 16 18 28 ||||||-|||||-||-|-----||-------||||||-----|||-|------||----------- 28 [E] COG0710 3-dehydroquinate dehydratase 8 14 22 46 --|-------------|||||-----|||||||||||||||||||||||||||||||||||||||| 62 [C] COG0711 F0F1-type ATP synthase, subunit b 8 15 23 47 -------------||-|||||-----|||||||||||||||||||||||||||||||||||||||| 48 [C] COG0712 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) 7 13 18 32 --||||------|---|-||-|-----||-------------||||||-|--|||||||||||||| 34 [C] COG0713 NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) 10 21 27 42 |||||||||||||---||||-|---||||||---||||----|||||-||--|--|---|||||-- 105 [R] COG0714 MoxR-like ATPases 10 18 23 33 -||-----||---||--|||||||--|---|--||-||----||||--||||---|---|||||-- 112 [P] COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components 7 16 21 32 |||-----||---||---|||---|-----||||-||-----|||||||||||--||||------- 71 [C] COG0716 Flavodoxins 8 20 28 47 |||||||||||||---|-||--||--|||||------|----||||||-||||||||||||||||| 53 [F] COG0717 Deoxycytidine deaminase 9 15 23 48 -----------------|||||||-||||||||||||||||||||||||||||||||||||||||| 48 [S] COG0718 Uncharacterized protein conserved in bacteria 10 20 25 43 |||||||||||||----|||-||||-||||||||||||----|||||-----|------|||||-- 85 [O] COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component 7 19 27 43 ||||||||||||----||||----------|---|-||----|||||-|||||||||||||||||| 55 [H] COG0720 6-pyruvoyl-tetrahydropterin synthase 12 23 28 46 ||||----||-||---||||||||||||||||||||||--||-------|---||||||||||||| 47 [J] COG0721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit 6 9 15 23 -------------||----|-|----|----|-|--------||||||||||||||------||-- 40 [E] COG0722 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase 9 17 24 36 --||||----|||||-|-||-|----|||||-----||----------||--|||||||||||||| 55 [C] COG0723 Rieske Fe-S protein 5 8 8 9 -------------|||--||----|-----------------------|-------||-------- 121 [R] COG0724 RNA-binding proteins (RRM domain) 8 20 26 43 |||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||-- 52 [P] COG0725 ABC-type molybdate transport system, periplasmic component 11 20 25 41 --|--|-|-|---|||-|||||||---|||||||||||----|||||-||--|--|||-|||||-- 122 [G] COG0726 Predicted xylanase/chitin deacetylase 6 14 18 27 -|||--|||-||------||-|---------||---------|||||-||--|--||||-|-|--- 43 [R] COG0727 Predicted Fe-S-cluster oxidoreductase 10 14 21 39 ----------------|||||||||||||||-----------|||||||||||||||||||||||| 41 [R] COG0728 Uncharacterized membrane protein, putative virulence factor 3 5 11 20 ----------------|---|---------------------|||||-||||||||---|||||-- 22 [M] COG0729 Outer membrane protein 10 22 31 48 |||||||||||||---||||||----|--|||--||||----|||||-||||||||||||||||-- 153 [R] COG0730 Predicted permeases 8 17 19 23 |||||||||||||||--||||---------|-------------------------|||------- 30 [C] COG0731 Fe-S oxidoreductases 5 14 21 35 ||||-|-||----------|-------||--|||||--|||||||-|-|||||---|||-||-|-| 88 [V] COG0732 Restriction endonuclease S subunits 8 14 16 25 -|||--|||-------|---|-|||-|------|||||----------|-||-||-|||------- 43 [R] COG0733 Na+-dependent transporters of the SNF family 11 19 28 48 --|-||--|-|||---||||||---||||||||-||||--|||||||-||||||||||||||||-- 91 [P] COG0735 Fe2+/Zn2+ uptake regulation proteins 10 16 21 46 -------------||-||--|||||||||||||||||||||||||||||----||||||||||||| 49 [I] COG0736 Phosphopantetheinyl transferase (holo-ACP synthase) 10 18 21 33 |--|----|----||-|||--|--|-|---|||-||||-|--|||||-|-||---|||-||-|--- 69 [F] COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases 3 6 9 15 -------------|----------------------|-----|||-|---|-|||-|||--|-|-- 17 [G] COG0738 Fucose permease 9 14 22 42 ----------------||||||--||||||||--||||----|||||||||||||||||||||||| 147 [M] COG0739 Membrane proteins related to metalloendopeptidases 10 15 23 46 ----------------||||||||||||||||||||||----|||||||||||||||||||||||| 84 [OU] COG0740 Protease subunit of ATP-dependent Clp proteases 6 11 19 37 ----------------||||----||----||||-|||----|||||||||||||||||||||||| 114 [M] COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) 9 15 23 46 -----------------|||||||||||||||||||||-|--|||||||||||||||||||||||| 46 [L] COG0742 N6-adenine-specific methylase 10 15 21 37 ----------------|||||||||-|||||----|||----|||||||||||||||||||--|-- 37 [I] COG0743 1-deoxy-D-xylulose 5-phosphate reductoisomerase 7 12 19 39 -----------------|||||----||||||||||||----||||||||||||||||||||||-- 91 [M] COG0744 Membrane carboxypeptidase (penicillin-binding protein) 9 14 22 43 ----------------||||||||--||||||||||||----|||||-|||||||||||||||||| 429 [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain 8 19 26 43 |||||||||||||---|-||-|----|||-----||||----|||||-||||--||||||||||-- 45 [H] COG0746 Molybdopterin-guanine dinucleotide biosynthesis protein A 11 20 26 46 --|||||||-|||---||||||||--|||||||-||||----|||||-||||---||||||||--- 248 [E] COG0747 ABC-type dipeptide transport system, periplasmic component 2 5 7 12 ------------------||----------------------------||||----|||||-|--- 14 [P] COG0748 Putative heme iron utilization protein 11 16 24 46 -------------|--||||||||||||||||||||||----|||||-|||||||||||||||||| 46 [L] COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains 12 24 34 58 |||||||||||||---||||||||||||||||||||||----|||||-|||||||||||||||||| 78 [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1 7 11 19 37 ----------------|||||-||-------|||-|||----|||||||||||||||||||||||| 37 [J] COG0751 Glycyl-tRNA synthetase, beta subunit 7 11 19 37 ----------------|||||-||-------|||-|||----|||||||||||||||||||||||| 37 [J] COG0752 Glycyl-tRNA synthetase, alpha subunit 5 9 13 27 -------------||------|----|-------||||----|||||-||||-||||||||||--- 37 [P] COG0753 Catalase 2 4 6 12 ------------------|-----------------------|||||---|-----||||---|-- 21 [E] COG0754 Glutathionylspermidine synthase 8 13 21 38 --|-----|-|-|---|-||-|----||||----|-||----|||||-|||||||||||||||||| 42 [O] COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component 9 14 21 40 -------------||||---|-|||-||||||||-||-----||||||-|||||||||-||||||| 46 [F] COG0756 dUTPase 7 12 17 28 -----------------|||||----|||||-----||-------|-||||||--|||||||||-- 31 [E] COG0757 3-dehydroquinate dehydratase II 9 15 23 42 ----------------||||||--|||||-|-||||||||--|||||-||||||||||||||||-| 46 [LU] COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake 10 15 23 39 ----------------||||||||||-||-||||||||----|---|-|||||||||||||||||- 39 [S] COG0759 Uncharacterized conserved protein 10 16 24 43 -------------|||||||||--||----||||||||----|||||||||||||||||||||||| 109 [O] COG0760 Parvulin-like peptidyl-prolyl isomerase 10 15 21 38 ----------------|||||||||-|||||-----||----||||||||||||||||||||||-- 40 [IM] COG0761 Penicillin tolerance protein 8 13 18 37 -----------------||||-||||||||||||||||----|||||-||||---||||||-||-- 39 [S] COG0762 Predicted integral membrane protein 5 9 16 29 ----------------|-|||-||------------------|||||-|||||||||||||||||| 29 [M] COG0763 Lipid A disaccharide synthetase 8 13 21 40 ----------------||||||||------||||||||----|||||||||||||||||||||||| 69 [I] COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases 10 16 24 41 --|-----|-|-|----|||||||--|---||||||||----|||||-|||--||||||||||||| 191 [E] COG0765 ABC-type amino acid transport system, permease component 10 15 23 46 ----------------||||||||||||||||||||||----|||||||||||||||||||||||| 56 [M] COG0766 UDP-N-acetylglucosamine enolpyruvyl transferase 4 8 15 29 ----------------|-||-------|||------------|||||-|||||||||||||||||| 49 [Q] COG0767 ABC-type transport system involved in resistance to organic solvents, permease component 10 15 23 46 ----------------||||||||||||||||||||||----|||||||||||||||||||||||| 107 [M] COG0768 Cell division protein FtsI/penicillin-binding protein 2 11 17 25 48 |--------|------||||||||||||||||||||||----|||||||||||||||||||||||| 63 [M] COG0769 UDP-N-acetylmuramyl tripeptide synthase 11 19 27 50 |||------|------||||||||||||||||||||||----|||||||||||||||||||||||| 50 [M] COG0770 UDP-N-acetylmuramyl pentapeptide synthase 11 17 25 48 |--------|------||||||||||||||||||||||----|||||||||||||||||||||||| 48 [M] COG0771 UDP-N-acetylmuramoylalanine-D-glutamate ligase 10 15 23 46 ----------------||||||||||||||||||||||----|||||||||||||||||||||||| 92 [D] COG0772 Bacterial cell division membrane protein 10 15 23 46 ----------------||||||||||||||||||||||----|||||||||||||||||||||||| 60 [M] COG0773 UDP-N-acetylmuramate-alanine ligase 5 9 16 29 ----------------|-|||-||------------------|||||-|||||||||||||||||| 29 [M] COG0774 UDP-3-O-acyl-N-acetylglucosamine deacetylase 9 14 20 42 --|--------------|--|||||||||-||||||||||--||||||||||-|||||||||||-- 64 [F] COG0775 Nucleoside phosphorylase 11 17 25 51 ----||----------||||||||||-||||||||||||||||||||||||||||||||||||||| 112 [L] COG0776 Bacterial nucleoid DNA-binding protein 8 13 20 39 ----------------|-||||||--|||-||||||||----|||||-||||||||||||||||-- 40 [I] COG0777 Acetyl-CoA carboxylase beta subunit 10 22 31 50 |||||--||||||---||||||----||||||||||||----|||||-||||||||||||||||-- 161 [C] COG0778 Nitroreductase 9 14 22 42 ----------------||||||--|||||-||||||||----|||||-|||||||||||||||||| 42 [S] COG0779 Uncharacterized protein conserved in bacteria 6 10 19 33 ----------|-|---||||-------------||-||----|||||-|||||||||||||||||| 34 [R] COG0780 Enzyme related to GTP cyclohydrolase I 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [K] COG0781 Transcription termination factor 7 12 20 46 -----------------|---||||||||||||||||||||||||||||||||||||||||||||| 83 [K] COG0782 Transcription elongation factor 8 13 20 35 ---|--------------||||--|||----|||||||-|--|||||-|||||--|||||-|-||| 41 [P] COG0783 DNA-binding ferritin-like protein (oxidative damage protectant) 10 20 25 40 |-||--|||----|||-|||-|--||-||-|----|||----|||||-|||||--|||||||||-- 545 [T] COG0784 FOG: CheY-like receiver 11 17 19 30 |-|---|||-|-|---||||||--|-||||--||--||------------||----||-||||--- 44 [O] COG0785 Cytochrome c biogenesis protein 5 7 10 16 ------------------|-|-----|-------|-------|||||-|||--||-||-------- 19 [E] COG0786 Na+/glutamate symporter 9 14 22 43 --------------|-|-||||--||||||||||||||----|||||-|||||||||||||||||| 58 [M] COG0787 Alanine racemase 7 11 16 27 ---|------------|-||-|----|||-------||----|||-|-|||||--|||||||-|-- 34 [F] COG0788 Formyltetrahydrofolate hydrolase 8 14 22 42 --|-----|-------|-||||----||||||||||||----|||||-|||||||||||||||||| 178 [K] COG0789 Predicted transcriptional regulators 4 8 13 24 -------------|||-----|--------------------|||||-||||-|||||||||||-- 93 [R] COG0790 FOG: TPR repeat, SEL1 subfamily 6 11 18 35 ------------------||-|||--||||||---|||----|||||-||||||||||||||||-- 123 [M] COG0791 Cell wall-associated hydrolases (invasion-associated proteins) 9 13 19 33 ----------------||||||--|-|||||-----------|||||-||||||||||||||||-- 33 [L] COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase 11 16 24 42 ----||----||----||||||||||----|---||||----|||||-|||||||||||||||||| 56 [M] COG0793 Periplasmic protease 7 16 25 41 |||---|||||||---|---|-||------|---|||-----|||||-|||||||||||||||||| 51 [M] COG0794 Predicted sugar phosphate isomerase involved in capsule formation 7 11 18 32 -----------------|||||||||----------------|||||-|||||||||||||||||| 66 [R] COG0795 Predicted permeases 8 13 19 40 ----------------|-||||--||||||||||||||----||||||||||-|||||||||||-- 41 [M] COG0796 Glutamate racemase 5 9 16 29 ----------------|-||----||----|-----------|||||-|||||||||||||||||| 36 [M] COG0797 Lipoproteins 7 14 14 17 |-|---|-|----|---|||------|||-|----||--------------|--|----|------ 22 [P] COG0798 Arsenite efflux pump ACR3 and related permeases 9 13 21 43 ----------------||||-|||||||||-|||||||----|||||-|||||||||||||||||| 43 [S] COG0799 Uncharacterized homolog of plant Iojap protein 5 10 17 30 -----------------|||----|-----||||--||----|||||-||||||||||-|||||-- 40 [G] COG0800 2-keto-3-deoxy-6-phosphogluconate aldolase 10 16 24 44 -------------||-||||||||--||||||||||||----|||||-||||||||||||||||-| 48 [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase 10 16 24 46 ----------------||||||||||||||||||||||-|--|||||-|||||||||||||||||| 46 [R] COG0802 Predicted ATPase or kinase 12 21 26 42 |-||--|||-|-|---|||||||||-||||||||||||-------||--|||-||---|||-|-|| 68 [P] COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin 6 11 13 23 --------------|---||-|----|||-----|-|||----|||---||----|||-||||--- 25 [E] COG0804 Urea amidohydrolase (urease) alpha subunit 8 15 24 43 --||||--|-|||---|-||-|----||||----||||----|||||-|||||||||||||||||| 49 [U] COG0805 Sec-independent protein secretion pathway component TatC 9 14 22 44 ----------------||||||--||||||||||||||----|||||||||||||||||||||||| 44 [J] COG0806 RimM protein, required for 16S rRNA processing 11 18 25 45 ----||--|----||-||||||||--||||||-||-||----||||||||||||||||||||||-- 56 [H] COG0807 GTP cyclohydrolase II 8 13 21 39 ----------------||||||---|----||||||||----|||||||||||||||||||||||| 41 [J] COG0809 S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) 4 7 13 24 ----------------|--||---------------------|||||-||||||||||||||||-- 40 [M] COG0810 Periplasmic protein TonB, links inner and outer membranes 7 13 20 33 |-|------|------|-||||||------------------|||||-|||||||||||||||||| 71 [U] COG0811 Biopolymer transport proteins 10 15 23 46 ----------------||||||||||||||||||||||----|||||||||||||||||||||||| 48 [M] COG0812 UDP-N-acetylmuramate dehydrogenase 6 9 12 26 -----------|--------||--|------||||||-|||||||||||-||----||----|--- 28 [F] COG0813 Purine-nucleoside phosphorylase 5 8 11 20 -------------|||------||--|---------------|||||-||||-||-|||------- 75 [E] COG0814 Amino acid permeases 8 12 18 35 ----------------||||-|||||||||------------|||||-||||-||||||||||||| 39 [M] COG0815 Apolipoprotein N-acyltransferase 9 15 23 47 ----------------||||||||--|||||||-|||||||||||||||||||||||||||||||| 47 [L] COG0816 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) 8 12 19 35 -----------------||||||||-||||------------|||||-|||||||||||||||||| 35 [L] COG0817 Holliday junction resolvasome, endonuclease subunit 5 10 16 32 -----------------|||-|--------||||||||----|||||-|||||||||||||||--- 35 [M] COG0818 Diacylglycerol kinase 7 11 14 23 ----||||--|||||----|------|----|-|||||------------||----|||--|---- 31 [K] COG0819 Putative transcription activator 9 15 22 41 ----------------||||||--|-|||-|||||||||---||||||||||||||||||||||-- 46 [R] COG0820 Predicted Fe-S-cluster redox enzyme 10 15 21 38 ----------------|||||||||-|||||-----||----||||||||||||||||||||||-- 38 [I] COG0821 Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis 12 20 27 53 --||----|----|||||-||-||||||||||||||||||||||||||||||-||||||||||||| 60 [C] COG0822 NifU homolog involved in Fe-S cluster formation 4 9 15 27 --|-----|---------||--||------------------|||||-|||||--||||||||||| 38 [U] COG0823 Periplasmic component of the Tol biopolymer transport system 10 18 26 43 |-||||----|||---|-||||--|-|||-|---||||----|||||-||||||||||||||||-- 80 [R] COG0824 Predicted thioesterase 8 13 20 39 ----------------|-||||||--|||-||||||||----|||||-||||||||||||||||-- 40 [I] COG0825 Acetyl-CoA carboxylase alpha subunit 8 15 20 35 |||------|-|----|--|||--------||||||||----|||||-||||-|||||||||---- 75 [O] COG0826 Collagenase and related proteases 4 7 8 17 -|-------------------------|||||||||||------------|-----||-|--|--- 22 [L] COG0827 Adenine-specific DNA methylase 6 12 20 42 ----------------|-||--||||----|||||||||-|||||||||||||||||||||||||| 46 [J] COG0828 Ribosomal protein S21 6 11 13 19 --------------|---||-|----|-------|--||----||----||----|||-||||--- 21 [O] COG0829 Urease accessory protein UreH 6 11 13 22 --------------|---||-|----|||-----|--||----|||---||----|||-||||--- 24 [O] COG0830 Urease accessory protein UreF 6 11 13 23 --------------|---||-|----|||-----|-|||----|||---||----|||-||||--- 25 [E] COG0831 Urea amidohydrolase (urease) gamma subunit 6 11 13 22 --------------|---||-|----|||-----|-|||----|||---||----|||--|||--- 24 [E] COG0832 Urea amidohydrolase (urease) beta subunit 3 7 9 16 -------------||---------------||--|||-----|||||--|-----|||-------- 54 [E] COG0833 Amino acid transporters 11 17 25 46 --|-----|-|-|----||||||||-||||||||||||----|||||-||||-||||||||||||| 270 [ET] COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain 6 14 18 30 --||--|||--------|||----||----|----|||----|||||-||--|--||||||-||-- 76 [NT] COG0835 Chemotaxis signal transduction protein 7 13 18 27 --||--|||-------||||-|--------|-----------|||||-||--|---||-|||||-| 37 [M] COG0836 Mannose-1-phosphate guanylyltransferase 2 6 10 19 ------------------||----------------------|||||--|--||||||-|||||-- 21 [G] COG0837 Glucokinase 7 14 21 35 --||||--|-|||---|-||-|-----||-------------||||||-|--|||||||||||||| 38 [C] COG0838 NADH:ubiquinone oxidoreductase subunit 3 (chain A) 7 14 20 34 --||||--|--||---|-||-|-----||-------------||||||-|--|||||||||||||| 40 [C] COG0839 NADH:ubiquinone oxidoreductase subunit 6 (chain J) 7 15 19 31 --||--|||--------|||-|--||----|----|||----|||||-||--|--||||||-||-- 323 [NT] COG0840 Methyl-accepting chemotaxis protein 9 14 21 35 --|-------------||||||---|----|---|-||----|||||-|||||||||||||||||| 149 [V] COG0841 Cation/multidrug efflux pump 10 22 30 48 |-||||||||||||||-|||-|----||||||||||||----|||||-||-||--|||-|||||-- 200 [V] COG0842 ABC-type multidrug transport system, permease component 9 12 18 33 ---|------||||--|-||-|----||||----||||----||||||-|--|--|---||||||| 60 [C] COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 9 14 22 39 ----------------||||||--|||---|-||||||----|||||-|||||||||||||||||| 288 [M] COG0845 Membrane-fusion protein 11 19 25 38 ------||||||||||||--||----|||||-|-||||-|--|||||-||-|---||||----|-- 49 [K] COG0846 NAD-dependent protein deacetylases, SIR2 family 12 18 26 47 ----|---|----||||||--||||-|||-||||||||----|||||||||||||||||||||||| 95 [L] COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases 6 10 17 30 ----------------|-||||||------------------|||||-|||||||||||||||||| 65 [U] COG0848 Biopolymer transport protein 8 12 20 39 ---------|------||--||--||----||||||||----|||||||||||||||||||||||| 42 [D] COG0849 Actin-like ATPase involved in cell division 7 12 17 29 ----------------||||||--------|----|||----||||||||-|||||||-||||--- 29 [D] COG0850 Septum formation inhibitor 4 8 12 22 ------------------||||--------------------||||||||--||||||-||||--- 22 [D] COG0851 Septum formation topological specificity factor 8 16 23 38 --|||||||-|||---||||-|-----||-------------||||||-|--|||||||||||||| 40 [C] COG0852 NADH:ubiquinone oxidoreductase 27 kD subunit 7 12 16 30 ----------------||||-|----|||||---||||----|||||--|--||||||||--||-- 31 [H] COG0853 Aspartate 1-decarboxylase 3 7 12 22 ----------------|-||----------------------|||||-||--||||||||||||-- 22 [H] COG0854 Pyridoxal phosphate biosynthesis protein 6 11 16 28 --|---------------||-|-----||||------|----|||||-||--||||||||||||-- 28 [P] COG0855 Polyphosphate kinase 1 6 6 7 ||||||--|--------------------------------------------------------- 8 [F] COG0856 Orotate phosphoribosyltransferase homologs 5 9 12 22 ---|----|---------||-|-----||-------------||||||||||-||-|||------- 23 [R] COG0857 BioD-like N-terminal domain of phosphotransacetylase 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [J] COG0858 Ribosome-binding factor A 4 8 14 22 ----------------|-|||---------------------|||||-|||||||||||---||-- 70 [M] COG0859 ADP-heptose:LPS heptosyltransferase 9 14 20 40 ----------------|-|||||||||||||---||||----||||||||||||||||||||||-- 85 [M] COG0860 N-acetylmuramoyl-L-alanine amidase 5 10 17 35 ------------------||-|----|||-|---||||----|||||||||||||||||||||||| 74 [P] COG0861 Membrane protein TerC, possibly involved in tellurium resistance 7 13 19 29 -|-||||----------|-|||----------|--|-|----|||||-|-|-||-|||-|||||-- 63 [L] COG0863 DNA modification methylase 4 13 16 23 ||||--|||||||-----------------|----|||----|||-|---------||---|-|-- 30 [K] COG0864 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain 5 11 11 18 |||-----||-----------|---|----|----|||----|||--------------||||--- 25 [F] COG1001 Adenine deaminase 7 15 16 21 -|||||----|----------|---||---|-----|-|----||-|---|---|-|||----|-- 39 [V] COG1002 Type II restriction enzyme, methylase subunits 10 16 21 35 ---|||||---||||-||||-|-----|||----||||----|||||--|--|-||---|||||-- 36 [E] COG1003 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain 7 15 22 33 -|||---||--|----|-||------|||---|---||----|||||-||-||--|--|||||||| 44 [M] COG1004 Predicted UDP-glucose 6-dehydrogenase 7 14 21 35 --||||--|-|||---|-||-|-----||-------------||||||-|--|||||||||||||| 38 [C] COG1005 NADH:ubiquinone oxidoreductase subunit 1 (chain H) 7 13 15 22 ||||--||---------|||-|----|-------||||----------||---------|||--|| 33 [P] COG1006 Multisubunit Na+/H+ antiporter, MnhC subunit 7 14 21 35 --||||--|-|||---|-||-|-----||-------------||||||-|--|||||||||||||| 37 [C] COG1007 NADH:ubiquinone oxidoreductase subunit 2 (chain N) 6 12 17 31 --||||----------|-||-|-----||-------------||||||-|--|||||||||||||| 40 [C] COG1008 NADH:ubiquinone oxidoreductase subunit 4 (chain M) 8 16 24 42 --||||-||-|||---|-||-|----|||-----||||----||||||||--|||||||||||||| 65 [CP] COG1009 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit 7 17 19 24 ||||||--||||------|||------||-|----|----------|--|-----|---||||--- 25 [H] COG1010 Precorrin-3B methylase 11 20 27 44 ||||--||-|||-|||-|-|-|--|||||-||||||||----|||||-||-|-|||---|||||-- 134 [R] COG1011 Predicted hydrolase (HAD superfamily) 10 22 31 50 ||||||---||||||-|-||||----|||||||||||||---|||||-||-|-|||||||||||-| 358 [C] COG1012 NAD-dependent aldehyde dehydrogenases 11 22 26 37 |||||||||||||||-|||||---|--||-||--||-|----|||||-|-------|||------- 79 [C] COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit 10 22 27 38 |||||||||||||---|||||---|--||-||--||-|----|||||-|------||||---||-- 89 [C] COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit 4 8 10 23 -----------------|---|--------||||||||-|--|||||||-------||-||-|--- 25 [G] COG1015 Phosphopentomutase 6 10 13 19 -------------||-|----|----|-------|-||----|||||-||--|--|--|-|----- 19 [C] COG1017 Hemoglobin-like flavoprotein 7 10 15 28 ---|---------||-----||----|||-----|-||----||||||||--||||---|||||-- 78 [C] COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 3 11 11 13 |||||||||||--||--------------------------------------------------- 13 [R] COG1019 Predicted nucleotidyltransferase 5 9 12 25 -------------||----|------||||-||||||-----|||||-||-----|--||-||--- 145 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins 3 4 6 11 ---------------------------||-------|-----|||||-||-----------|---- 11 [Q] COG1021 Peptide arylation enzymes 10 13 17 22 ---|----|-|-|||||-|||---||||||---------------|--||||-------------- 36 [I] COG1022 Long-chain acyl-CoA synthetases (AMP-forming) 6 6 7 10 ---|------------|----|-----||--|----||---------------------|--|--- 10 [G] COG1023 Predicted 6-phosphogluconate dehydrogenase 10 16 24 39 ---|||--|-|||||-|--|||----|||||-|||-||----|||||-||--|--|---||||||| 245 [I] COG1024 Enoyl-CoA hydratase/carnithine racemase 4 5 7 12 -------------|||------||------------------|||||-||---------------- 13 [O] COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like 5 6 6 8 -------------||------|||||----|----------------------------------- 11 [R] COG1026 Predicted Zn-dependent peptidases, insulinase-like 6 10 13 24 ----||-----------|-|------|---|-----||----|||||-||||-||-||||-|---- 25 [E] COG1027 Aspartate ammonia-lyase 13 23 33 57 --|||||||-||||||||||||||--||||||||||||----|||||||||||||||||||||||| 825 [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) 1 5 5 5 |||-----||-------------------------------------------------------- 12 [C] COG1029 Formylmethanofuran dehydrogenase subunit B 5 10 11 16 --|-|||||-|-|---|-----------------|-||-----------|-----|----|-|--- 18 [O] COG1030 Membrane-bound serine protease (ClpP class) 3 8 9 10 -|||--|||||-|----|------------------------------------------------ 10 [C] COG1031 Uncharacterized Fe-S oxidoreductase 9 18 23 29 |||-|||||||||----|||||-----||-||-----|----|||-|-||------------|--- 87 [C] COG1032 Fe-S oxidoreductase 5 11 11 13 -|||--||||-------|------||-----------|-----------|--------|------- 19 [R] COG1033 Predicted exporters of the RND superfamily 7 11 16 29 ----------------||||-|-----||-|-----------||||||-|--|||||||||||||| 30 [C] COG1034 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) 3 8 8 8 |||-----||--------||----------------------------------------|----- 22 [C] COG1035 Coenzyme F420-reducing hydrogenase, beta subunit 1 5 5 5 |||-----||-------------------------------------------------------- 8 [C] COG1036 Archaeal flavoproteins 4 6 7 15 -------------||-----------|||-||--||||---------------------||||--- 16 [C] COG1038 Pyruvate carboxylase 3 4 5 13 ----------------|-----||-------||||||-||||------------------------ 13 [L] COG1039 Ribonuclease HIII 9 14 22 40 ----------------||||||--||-||-||||||||----|||||-||||||||||||||||-| 43 [R] COG1040 Predicted amidophosphoribosyltransferases 3 11 13 15 |||||||||||||||--------------------------------------------------- 17 [L] COG1041 Predicted DNA modification methylase 4 12 15 23 -|||||||||||-------|----------------------|||||-||---||-----|-|--- 47 [C] COG1042 Acyl-CoA synthetase (NDP forming) 5 9 16 29 ----------------|-|||-||------------------|||||-|||||||||||||||||| 29 [M] COG1043 Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase 5 9 16 29 ----------------|-|||-||------------------|||||-|||||||||||||||||| 33 [M] COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 7 13 19 39 --||----------|--|||------||||||||||||----||||||||||-|||||||||||-- 53 [E] COG1045 Serine acetyltransferase 6 15 22 32 |||||||||||||-------||--|-----------------|||||-|||||||||||------- 44 [O] COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 8 14 23 38 --||||----|||||-|----|----||||||--|||-----|||||-||--||||---||||||| 48 [C] COG1048 Aconitase A 2 6 11 18 ------------------||----------------------|||||-||-|||||||||------ 18 [C] COG1049 Aconitase B 8 17 24 34 |||---|||||||---|-||-|----||||||-|-|||-------|--||-----|---|||||-| 56 [F] COG1051 ADP-ribose pyrophosphatase 9 16 24 40 ----||||--|||||-|-|||---|-----|-|-||||----|||||-||||-|||||||||||-- 92 [CHR] COG1052 Lactate dehydrogenase and related dehydrogenases 12 23 33 53 ||-|||--|||||||-||||||||--||||||--||||----|||||-|||||||||||||||||| 83 [C] COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit 6 9 15 29 ------------------||-|||--|----||||||-----||||||||--|--|---||||||| 29 [R] COG1054 Predicted sulfurtransferase 9 15 20 33 ----|||||-|||----||||-||---|||----||||----||||--||---|||--||--|--- 44 [P] COG1055 Na+/H+ antiporter NhaD and related arsenite permeases 7 14 17 25 |||||||||-|||-----|--|-----||--|----------|||||---||---|---------- 29 [H] COG1056 Nicotinamide mononucleotide adenylyltransferase 9 16 22 45 -------------||-|||||---||||||||||||||||||||||||||--||||||||||||-- 50 [H] COG1057 Nicotinic acid mononucleotide adenylyltransferase 10 17 23 39 ---||||||-||||---|||||-----||||-||||||----|||||-|----|||---|||||-- 40 [R] COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA 5 7 7 8 -|--||--|--|----||--|--------------------------------------------- 8 [L] COG1059 Thermostable 8-oxoguanine DNA glycosylase 11 20 22 32 ||||||--|||-|---||||||||---||||------|----|||||-|-------|||------- 57 [HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes 11 17 21 32 --|||||||-||||||---|||--|-|||||-||||------|||||-|----------------- 64 [KL] COG1061 DNA or RNA helicases of superfamily II 6 10 14 25 -----------|-||---||------||||-------|----|||||--||--|||---|||||-- 42 [C] COG1062 Zn-dependent alcohol dehydrogenases, class III 9 18 26 41 --|||||||--||||--|-|-|-----||-||||||||--|-|||||-|||-||||---||-||-- 159 [ER] COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases 7 13 19 36 --|-||----|||||---||------||||-||||-||----|||-|--|--|||||||||||--- 83 [R] COG1064 Zn-dependent alcohol dehydrogenases 10 15 23 42 ----------------|||||||||-|||-|||-||||----|||||-|||||||||||||||||| 43 [O] COG1066 Predicted ATP-dependent serine protease 5 13 16 24 ||||||||||-------|------|-----|-----||----|||||-||||-------------- 32 [O] COG1067 Predicted ATP-dependent protease 3 4 4 13 -------------|--------------------|-||----|||||------------||||--- 17 [C] COG1069 Ribulose kinase 9 14 17 32 --------|---|||--|||----|||||-||-|||||----|||||--|||---|---||||--- 90 [G] COG1070 Sugar (pentulose and hexulose) kinases 10 16 21 35 ---|||----||||||--||-|||---||--|||||||-|||-------|-----|---||||||| 58 [C] COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit 5 7 10 25 -----|-------||-----------||||-|||-|||----|||||-|-||-------||||--- 33 [H] COG1072 Panthothenate kinase 12 19 25 38 --||---||---||||-|-|||||--|||-|||--|||----|||||-||-||--|---|||||-- 89 [R] COG1073 Hydrolases of the alpha/beta superfamily 6 10 18 39 --------------------|-||||-||-||||||||----|||||||||||||||||||||||| 39 [L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) 7 12 14 16 --------|----||---||-|----|---|---|-||-|--------||--|--|---------- 24 [R] COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold 4 8 14 25 -------------|||--|-----------------------||||||||||-|||--|||||||| 37 [O] COG1076 DnaJ-domain-containing proteins 1 9 16 21 34 |---||--||------||-||-||||----|----|||----|||||-|||||--||||----||| 43 [D] COG1077 Actin-like ATPase involved in cell morphogenesis 7 15 18 27 |||||||||||||--|||--|----------||||||||-||------------------------ 34 [R] COG1078 HD superfamily phosphohydrolases 8 14 16 27 ---|--|||-|-|----|-|-|--||----||||-||-||||-------|-----|---||||--- 42 [R] COG1079 Uncharacterized ABC-type transport system, permease component 7 11 18 33 --------------------||||-||---||||||||-|||||||||||||||||------||-- 49 [G] COG1080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) 7 16 19 33 |||---||||-|-----|||------|||||-|-||||----|||||--|-----|---|||||-- 115 [G] COG1082 Sugar phosphate isomerases/epimerases 3 5 5 7 --|---------------|-------------------------------||-|--|-|------- 9 [M] COG1083 CMP-N-acetylneuraminic acid synthetase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [R] COG1084 Predicted GTPase 7 11 13 19 --|---|-|-|--||--|--------||--||----------|||||-|-||-------------- 21 [C] COG1085 Galactose-1-phosphate uridylyltransferase 7 11 18 26 -|---------------|--|---|-|---|--||-||----------||-||||||||-|||||| 34 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases 9 16 22 37 |------------||-|-||||----|---||-|-|||--|||||||-||||-|||||||||||-- 54 [M] COG1087 UDP-glucose 4-epimerase 9 17 24 38 |-|--||||--||-|---||||----|||||||---||----|||||--|||||||---||-||-- 45 [M] COG1088 dTDP-D-glucose 4,6-dehydratase 6 11 15 22 |-|-----|-------|-||-------||-|-----------|||-|-||--|---||-|-|||-- 29 [M] COG1089 GDP-D-mannose dehydratase 5 6 9 21 ----||------------||------||||----||||----|||||--||||------------- 21 [R] COG1090 Predicted nucleoside-diphosphate sugar epimerase 9 18 25 36 |-||-||||--||---|-||||----|||||||---||----|---|--|--||||---||-|||| 44 [M] COG1091 dTDP-4-dehydrorhamnose reductase 9 13 19 35 -|----||-|--|---||--||||-------||||||-----||||||||||||||---||||--- 48 [R] COG1092 Predicted SAM-dependent methyltransferases 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG1093 Translation initiation factor 2, alpha subunit (eIF-2alpha) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [R] COG1094 Predicted RNA-binding protein (contains KH domains) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [K] COG1095 DNA-directed RNA polymerase, subunit E' 3 9 11 13 |-|-|||||||||||--------------------------------------------------- 13 [J] COG1096 Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain) 4 10 12 14 |-|-||||||||||||-------------------------------------------------- 17 [J] COG1097 RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain) 3 4 5 10 -----------------|---|--------||||||||---------------------------- 14 [J] COG1098 Predicted RNA binding protein (contains ribosomal protein S1 domain) 2 5 5 5 ||------||---------|---------------------------------------------- 7 [R] COG1099 Predicted metal-dependent hydrolases with the TIM-barrel fold 8 17 19 21 |||||||||||||||||-||-|----------------------------------------|--- 114 [R] COG1100 GTPase SAR1 and related small G proteins 4 6 8 13 --------------------|-----|-----||--------------||-----|---||||-|| 13 [R] COG1101 ABC-type uncharacterized transport system, ATPase component 3 10 12 15 |||||||||||||-----------||---------------------------------------- 15 [F] COG1102 Cytidylate kinase 1 5 5 5 |||-----||-------------------------------------------------------- 6 [R] COG1103 Archaea-specific pyridoxal phosphate-dependent enzymes 13 20 27 49 --|-----|----||||||||||||-||||||||||||----||||||||||-||||||||||||| 76 [E] COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes 7 10 14 27 -----------------|--||---||||-||||||||--|||||||-||||---|---------- 38 [G] COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) 5 6 6 8 -|----||---|-------||-----------------------------------||-------- 14 [R] COG1106 Predicted ATPases 1 7 7 8 ||||--||||-------------------------------------------------------- 9 [L] COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain 12 21 27 47 |-||--|||-|-|---|||||||||-||-|||||||||----||||||||||-||---|||||-|| 81 [P] COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components 14 28 38 65 |||||||||||||||||||||||||||||||||||||||-|||||||||||||||||||||||||| 147 [G] COG1109 Phosphomannomutase 4 7 9 10 -|----|||||||---||------------------------------------------------ 16 [L] COG1110 Reverse gyrase 2 10 10 12 ||||||||||---||--------------------------------------------------- 13 [L] COG1111 ERCC4-like helicases 11 23 25 34 |||||-||||-|-||||||-|------||||---|---|||||||-|--|--|---|--------| 60 [L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits 3 5 7 19 --------------------------|||||||-||||----|||||--|---------|-|---- 77 [E] COG1113 Gamma-aminobutyrate permease and related permeases 6 7 11 19 --------------------|-|||-|---|-|||-|-----|||||-||||-------------- 24 [E] COG1114 Branched-chain amino acid permeases 8 12 16 29 --|---||------------|||||-|-----|||-||----|||-|-||||-||-|||-||---- 57 [E] COG1115 Na+/alanine symporter 10 18 24 35 -||-||--||||-----|||||||--|---|--||-||----||||---||||--|---|||||-- 90 [P] COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component 10 22 30 48 ||||---||||||---||||-|---||||||||||||||-|||||||-|||||--|--||||||-- 64 [P] COG1117 ABC-type phosphate transport system, ATPase component 4 8 13 24 ------------------||-------||--------|----|||||-||--||||||||||||-- 34 [P] COG1118 ABC-type sulfate/molybdate transport systems, ATPase component 6 7 9 19 --|----------||------|----||||-|--||||----|||||----|-------------- 20 [P] COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA 9 20 26 44 -||||||||--||----|||||----|---|-|||||||-|||||||-||||---|||||||||-- 118 [PH] COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components 12 21 28 47 |-||--|||-|||---|||||||||-|--|||||||||----||||||||||-||---|||||-|| 70 [P] COG1121 ABC-type Mn/Zn transport systems, ATPase component 10 21 26 42 ||||--|||||||----|||||--|-||||||||||||||||-||-|-|-|----|---|||---- 102 [P] COG1122 ABC-type cobalt transport system, ATPase component 7 15 16 26 |||-|----|-|------|||-----||||----|-------|||||-|------|||-||-|--- 72 [R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase 5 8 9 19 --|--|--------------|-||--------|-|--|||--|||||------------||||--- 28 [EP] COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component 7 10 12 25 --------|----------|||-----||-|||||||-----|||||--|------||-||||--- 31 [E] COG1125 ABC-type proline/glycine betaine transport systems, ATPase components 10 16 24 41 --|-----|-|-|----|||||||--|---||||||||----|||||-|||--||||||||||||| 130 [E] COG1126 ABC-type polar amino acid transport system, ATPase component 4 8 15 29 ----------------|-||-------|||------------|||||-|||||||||||||||||| 35 [Q] COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component 6 9 14 24 -----------------|--|---|||----|----||-|--|||||-||||---|---|||||-- 168 [G] COG1129 ABC-type sugar transport system, ATPase component 11 24 33 54 |-||||||||||||||-|||-|---||||||||||||||||-|||||-||-|||||||-|||||-- 323 [V] COG1131 ABC-type multidrug transport system, ATPase component 13 22 31 57 --||--||--||-|||||||||||--|||||||||||||||||||||||||||||||||||||||| 302 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components 1 3 3 9 ------------------------------------------|||-|-----------|||||--- 9 [I] COG1133 ABC-type long-chain fatty acid transport system, fused permease and ATPase components 6 12 19 30 --|-----|-------|-||------|||||||-||||--------|-||-||||---|-|||||| 38 [GM] COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component 8 13 20 36 ------------------||||-||-|---||||||||----|||||-||||||||||||||||-- 41 [P] COG1135 ABC-type metal ion transport system, ATPase component 12 23 33 58 ||||----|||||---|||||||||||||-|||||||||||||||||||||||||||||||||||| 228 [V] COG1136 ABC-type antimicrobial peptide transport system, ATPase component 8 12 19 33 ----------------||||||||||----------------|||||-|||||||||||||||||| 33 [R] COG1137 ABC-type (unclassified) transport system, ATPase component 4 6 13 22 --|-----|-|-|--------|--------------------|||||-|||||------||||||| 29 [O] COG1138 Cytochrome c biogenesis factor 6 11 16 23 |--|||--|-|||-------||---------|----||----|||------|-||||||------- 24 [C] COG1139 Uncharacterized conserved protein containing a ferredoxin-like domain 4 6 8 14 ----------|-|-------------|||-----|-|-----|||-|--|-----|-----|---- 18 [C] COG1140 Nitrate reductase beta subunit 6 11 13 19 |--|---||-|-|----|||-------||-||||||||---------------------------- 27 [C] COG1141 Ferredoxin 4 10 10 15 |||---||||-------|||----------------------|||||------------------- 45 [C] COG1142 Fe-S-cluster-containing hydrogenase components 2 8 18 25 40 |||||||||-|||---||||-|-----||-------------||||||-|--|||||||||||||| 52 [C] COG1143 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) 5 11 12 15 |||-||||||||----||--------------------------------------||-------- 22 [C] COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit 8 19 26 38 |||-|||||||||----|||||--------|-----|-----|||||-|||||||||||||-|--- 184 [C] COG1145 Ferredoxin 8 19 25 38 ||||||-|||||-----|||-|----|||||-----------|||-|-||--|--||||||||||| 84 [C] COG1146 Ferredoxin 4 8 8 8 |||-----||-|----||------------------------------------------------ 13 [C] COG1148 Heterodisulfide reductase, subunit A and related polyferredoxins 2 7 7 8 |||---||||-------|------------------------------------------------ 16 [C] COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain 3 7 7 7 |||-----||-|----|------------------------------------------------- 11 [C] COG1150 Heterodisulfide reductase, subunit C 5 10 10 14 |||----|||-------|--|---------|-----------|||||------------------- 19 [C] COG1151 6Fe-6S prismane cluster-containing protein 1 5 5 5 |||-----||-------------------------------------------------------- 10 [C] COG1152 CO dehydrogenase/acetyl-CoA synthase alpha subunit 1 5 5 5 |||-----||-------------------------------------------------------- 9 [C] COG1153 Formylmethanofuran dehydrogenase subunit D 10 15 22 40 ----------------|||||||||-||||||---|||----||||||||||||||||||||||-- 44 [HI] COG1154 Deoxyxylulose-5-phosphate synthase 9 17 19 24 ||||||||||||||||----||||||------||-------------------------------- 31 [C] COG1155 Archaeal/vacuolar-type H+-ATPase subunit A 9 17 19 24 ||||||||||||||||----||||||------||-------------------------------- 26 [C] COG1156 Archaeal/vacuolar-type H+-ATPase subunit B 6 10 13 27 ----------------||----||||----|----|||----||||||||-----|||||||||-- 41 [NU] COG1157 Flagellar biosynthesis/type III secretory pathway ATPase 9 13 20 41 ----------------||--|||||||||||---||||----|||||||||||||||||||||||| 41 [K] COG1158 Transcription termination factor 9 15 23 48 ----------------||||||--|||||||||||||||||||||||||||||||||||||||||| 48 [R] COG1159 GTPase 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 52 [R] COG1160 Predicted GTPases 10 18 21 31 -||---||-|||||||-||||----|----||||||||||||------|----||----------- 51 [R] COG1161 Predicted GTPases 9 14 20 37 --|-------------|||||----||||||||||||||||||||||-||||||||------|--- 40 [R] COG1162 Predicted GTPases 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [R] COG1163 Predicted GTPase 8 12 14 29 --||-------------|--||||||-----|||||||||||------|-------||||||||-- 41 [E] COG1164 Oligoendopeptidase F 5 6 9 19 ---|--------------||------||||-|--|||-----|||||-|-||-------------- 19 [H] COG1165 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase 3 6 10 17 ------------------||-|--------------------|||||-||-||||-|||------- 18 [E] COG1166 Arginine decarboxylase (spermidine biosynthesis) 10 15 22 38 ----||||--|||||--|-|||----|||||-||||||----|||||-||-|---|---|||||-- 107 [KE] COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs 5 7 9 19 --------------------||----||||||-|-|||----|||||---|----|---------- 21 [E] COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities 5 7 11 21 ---|--------------||------||||-|--|||-----|||||-||||---------|---- 27 [HQ] COG1169 Isochorismate synthase 10 16 26 44 ---|||----|||||--|||||----||||-|-|||||----|||||-||||||||--|||||||| 75 [E] COG1171 Threonine dehydratase 5 7 12 22 -----------------|--|-----|--|-|----||----|||||-||||---|---|||||-- 175 [G] COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components 12 22 28 51 --|||||||-|||---||||||||-||||||||||||||||||||||-||||---||-|||||--- 241 [EP] COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components 7 11 13 26 --------|----------|||-----||-|||||||-----|||||--|-----|||-||||--- 54 [E] COG1174 ABC-type proline/glycine betaine transport systems, permease component 9 16 23 42 ---|||||--|||----|||-|--|-||||||||||||-||||||||-||-||--|---||||--- 219 [G] COG1175 ABC-type sugar transport systems, permease components 9 14 21 37 ---|----|-|-|----|-|||--||----||||||--|||||||||-||||-|||---|||||-- 88 [E] COG1176 ABC-type spermidine/putrescine transport system, permease component I 9 15 22 38 ---|----|-|-|----|-|||--||----||||||--|||||||||-||||-|||--||||||-- 98 [E] COG1177 ABC-type spermidine/putrescine transport system, permease component II 9 14 20 30 ---|--||--|-|-----||||--|-|------|---|----|||||-||||-|||--|||||--- 65 [P] COG1178 ABC-type Fe3+ transport system, permease component 4 8 13 23 -------------||-----|---------|---|-||----|||||-|||||||||||------- 24 [H] COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 8 16 22 33 |||-|||||||||---||--|------||-||||||------|||||-||||---|---------- 70 [O] COG1180 Pyruvate-formate lyase-activating enzyme 11 16 24 46 --|-------------||||||||||||||||||||||----|||||-|||||||||||||||||| 65 [M] COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes 3 7 10 21 -------------------|----------||--||||-||||||||--||----|---||-|--- 29 [I] COG1182 Acyl carrier protein phosphodiesterase 8 18 21 32 ||||----||---||-----|-||-|-||||-----||-----------|--|||||||||||-|| 39 [I] COG1183 Phosphatidylserine synthase 4 10 11 13 -||||||||-|-|||--|------------------------------------------------ 20 [J] COG1184 Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family 11 17 25 48 -------------||-||||||||||||||||||||||----|||||||||||||||||||||||| 48 [J] COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) 11 17 25 47 -------------||-|||||||||||||||||-||||----|||||||||||||||||||||||| 66 [J] COG1186 Protein chain release factor B 10 16 24 47 ----------------||||||||||||||||||||||-|--|||||||||||||||||||||||| 99 [J] COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases 5 9 15 31 -----------------|--|-----|---||||||||----|||||-||||-|||||||||||-- 32 [J] COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) 9 14 17 31 --|-----|-------|||||----|||||||||-|||||----------------|||||||||| 31 [J] COG1189 Predicted rRNA methylase 13 20 27 49 --|-------||-|||||||||||--|||||||||||||||||||||||||||||||||||----- 59 [J] COG1190 Lysyl-tRNA synthetase (class II) 8 12 14 25 ----------------||||--|||--||-|---||||----|||||-||-----||||------- 45 [K] COG1191 DNA-directed RNA polymerase specialized sigma subunit 10 21 28 48 ||-|-|||-|||----|-||-||||||||||----|||--|||||||-||--|||||||||||||| 148 [D] COG1192 ATPases involved in chromosome partitioning 9 14 15 23 |-||--||--------||||||---|----||||||||------------------|||------- 26 [L] COG1193 Mismatch repair ATPase (MutS family) 9 14 22 43 |--|------|-|-|------||||-||||||||||||----||||||||||||||||||||||-- 44 [L] COG1194 A/G-specific DNA glycosylase 9 12 19 36 ----------|-------|||||-|-||||||||||||----|||||-|||||------||||||| 36 [L] COG1195 Recombinational DNA repair ATPase (RecF pathway) 12 23 26 44 -||||||||----|||||||||--||||||||||||||||||-------|--|||----|||||-- 60 [D] COG1196 Chromosome segregation ATPases 9 14 22 45 -----------------|||||||||||||||||||||----|||||||||||||||||||||||| 45 [LK] COG1197 Transcription-repair coupling factor (superfamily II helicase) 10 15 23 46 ----------------||||||||||||||||||||||----|||||||||||||||||||||||| 47 [L] COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase 10 20 28 43 ||||||||--|||||||-|||-----|||-||||||||----|||||-||||||||-------|-- 61 [KL] COG1199 Rad3-related DNA helicases 9 14 22 43 ----------------||||||--||||||||||||||----|||||-|||||||||||||||||| 43 [LK] COG1200 RecG-like helicase 5 14 18 27 |||||||||||||------|------|||-------------|||----|-----|---|||||-- 38 [R] COG1201 Lhr-like helicases 1 6 6 7 ||||--||-|-------------------------------------------------------- 7 [R] COG1202 Superfamily II helicase, archaea-specific 7 11 15 20 |||---|||-|||---||--|-----------|----|----|||||----|-------------- 28 [R] COG1203 Predicted helicases 6 15 17 20 |||||||||||||||||-------------------------|----------------||----- 26 [R] COG1204 Superfamily II helicase 8 15 16 21 |||---||||||-||----|-|----|||-------||-----||---------------|----- 27 [R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster 7 8 10 18 ----------------||||||---------|||||||---------------------|||||-- 18 [J] COG1206 NAD(FAD)-utilizing enzyme possibly involved in translation 8 13 21 42 ----------------||||||----||||||||||||----|||||||||||||||||||||||| 42 [M] COG1207 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) 10 23 29 40 |||||||||||||||||-||-|----|||||-----||-------||--|--||||--||||||-- 90 [MJ] COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) 8 17 23 37 |-|||||||--||----|||-|----|||||||---||----|||||--|--||||---||-||-- 48 [M] COG1209 dTDP-glucose pyrophosphorylase 9 17 24 44 |||----|---|----|--||----|||||||||||||--|||||||-||||||||||||||||-- 61 [M] COG1210 UDP-glucose pyrophosphorylase 11 17 24 44 ------|---------|||||||||-|||||--|||||--||||||||||||||||||||||||-- 46 [I] COG1211 4-diphosphocytidyl-2-methyl-D-erithritol synthase 4 7 14 27 ----------------|---|-||------------------|||||-|||||||||||||||||| 27 [M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase 5 9 9 10 |-----|||---|---|---|----------------------------|--------|----|-- 11 [M] COG1213 Predicted sugar nucleotidyltransferases 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 50 [O] COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone 9 19 24 37 |-|-||||||||-||||-||------|---|||-||||----|||||--|-----|---|||||-| 82 [M] COG1215 Glycosyltransferases, probably involved in cell wall biogenesis 7 14 18 25 |-|--||||---|-----||-|----|||||-----------|---|--||-|--|---||-||-- 54 [R] COG1216 Predicted glycosyltransferases 6 11 19 40 ------------------||||----||||||||||||----|||||||||||||||||||||||| 40 [T] COG1217 Predicted membrane GTPase involved in stress response 6 10 16 30 -------------||-|-||--||--||||------------|||||||||||-----|||||||| 31 [P] COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase 11 16 24 47 -------------|--||||||||||||||||||||||----|||||||||||||||||||||||| 47 [O] COG1219 ATP-dependent protease Clp, ATPase subunit 5 8 14 29 ----------------||-------|--------||||----|||||||||||--||||||||||| 29 [O] COG1220 ATP-dependent protease HslVU (ClpYQ), ATPase subunit 4 7 9 14 -----------------|||----------|----||-----|||||-||-----|---------- 28 [KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain 4 11 12 13 ||||--||||-|||||-------------------------------------------------- 31 [O] COG1222 ATP-dependent 26S proteasome regulatory subunit 1 5 5 5 |||-----||-------------------------------------------------------- 5 [R] COG1223 Predicted ATPase (AAA+ superfamily) 4 7 9 10 ------||||||||||-------------------------------------------------- 13 [K] COG1224 DNA helicase TIP49, TBP-interacting protein 10 18 27 44 --||||----|||||-||||-|----|||||---|-||----|||||-||||||||||||||||-| 70 [O] COG1225 Peroxiredoxin 10 23 32 50 ||||||||||-|||--||||-|----|||-||---|||||--|||||-|||-|||||||||||||| 134 [P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component 8 11 12 16 -|------|----|||-|--||--------|||||||-----------|----------------- 17 [C] COG1227 Inorganic pyrophosphatase/exopolyphosphatase 9 16 20 28 |--||||-|--|-|---|--||-----||-|-|-|-||-------||-||-----|---|||||-- 45 [Q] COG1228 Imidazolonepropionase and related amidohydrolases 1 5 5 5 |||-----||-------------------------------------------------------- 7 [C] COG1229 Formylmethanofuran dehydrogenase subunit A 11 17 24 37 --|---|---||-|||||-|-|----|--||||||||-----|||||--|-|||||--||||||-- 47 [P] COG1230 Co/Zn/Cd efflux system component 5 8 9 11 ------------------||-|----|||-------|------------|-----|------||-- 12 [E] COG1231 Monoamine oxidase 9 15 15 22 --||--|-|-|--||-|----|||--||||----||||-------|---------|-------|-- 22 [H] COG1232 Protoporphyrinogen oxidase 7 12 14 18 ||||-------||-----||-|----|||-----||-|-----------------|------||-- 53 [Q] COG1233 Phytoene dehydrogenase and related proteins 12 24 29 44 ||||||||||||||||-|||-|||||||||||||||||----|||-|----|---|------||-- 66 [R] COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III 9 20 24 40 ||||||||||----|-|-|||-||||----||||||||----||||---|-----|---||||||| 55 [R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I 7 16 20 23 -||||||-|-||||||--||-|--------------------------||-----|---||-||-- 37 [J] COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing 4 9 9 10 |||---||||-------|------------|---------------|------------------- 20 [R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II 3 8 15 25 -||------|------|-------------------------|||||-||||||||--|||||||| 34 [S] COG1238 Predicted membrane protein 5 13 13 16 ||||||--||--------||-|----|||--------------------|-----|---------- 22 [H] COG1239 Mg-chelatase subunit ChlI 4 11 11 14 ||||||---|--------||------|||--------------------|-----|---------- 15 [H] COG1240 Mg-chelatase subunit ChlD 4 12 14 16 ||||||||||||||||-------------------------------------------------- 45 [L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family 6 8 10 18 -|-------|------||--|---------|||-||||----|||||-|----------------- 18 [R] COG1242 Predicted Fe-S oxidoreductase 7 15 16 18 ||||||||||||-|||-|--|---------|----------------------------------- 18 [KB] COG1243 Histone acetyltransferase 2 9 9 11 ||||||||||--------------------|----------------------------------- 11 [R] COG1244 Predicted Fe-S oxidoreductase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog 6 8 12 21 --||------------|----|-----|||------||----||||||||-|-|||---------- 23 [E] COG1246 N-acetylglutamate synthase and related acetyltransferases 7 11 16 26 --|-------|-|-----||-|----|---||-|||||----|||-|-||-----|---|||||-- 31 [M] COG1247 Sortase and related acyltransferases 12 23 33 56 ||||||--|||||||-||||||||--||||-|||||||-|||||||||||||||||---||||||| 162 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes 7 12 18 31 ---|||--|-|||-------||-----||||---|-||----|||||-||-----|---||||||| 93 [I] COG1250 3-hydroxyacyl-CoA dehydrogenase 5 8 10 19 --|-------------|----------||-|---|-||----|||||--|-----|---||-||-- 24 [C] COG1251 NAD(P)H-nitrite reductase 8 12 16 29 ---|-------|-||---||-|----||||-|--||||----|||||-|||----|---||||--- 55 [C] COG1252 NADH dehydrogenase, FAD-containing subunit 12 20 28 52 --||---------||-|||||||||||||-|||||||-|||||||||||||||||||||||||||| 103 [R] COG1253 Hemolysins and related proteins containing CBS domains 9 16 22 34 -||-|||||-|||----|-|-|---|--|-||||||||----|||||-||-|---|----|-|--- 42 [C] COG1254 Acylphosphatases 1 5 5 6 ||-|--|||--------------------------------------------------------- 6 [S] COG1255 Uncharacterized protein conserved in archaea 5 9 12 25 ----------------||------||----|----|||----||||||||-----|||||||||-- 26 [N] COG1256 Flagellar hook-associated protein 7 15 18 23 ||||||||||||||||---------|-----|||||------------|----------------- 24 [I] COG1257 Hydroxymethylglutaryl-CoA reductase 3 10 12 14 |||||||||||||--|-------------------------------------------------- 14 [J] COG1258 Predicted pseudouridylate synthase 7 10 12 16 --||----|-|||---||||--||--||||------------------------------------ 16 [S] COG1259 Uncharacterized conserved protein 7 10 12 16 |-|---|||-||||--||--------||||------------------------------|----- 19 [I] COG1260 Myo-inositol-1-phosphate synthase 3 6 9 19 ----------------||------------------------||||||||-----|||||||||-- 20 [NO] COG1261 Flagellar basal body P-ring biosynthesis protein 7 10 15 22 --|-----------|---||--||---||-------||----------||-|||||---|||||-- 39 [S] COG1262 Uncharacterized conserved protein 5 9 13 25 --------------------|----||---||||||||-|||||||||||-|---|-------|-- 100 [G] COG1263 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific 5 9 13 26 --------------------|----||---||||||||||||||||||||-|---|-------|-- 107 [G] COG1264 Phosphotransferase system IIB components 12 19 24 37 |-||--||--|-|---|||||||||||||-||||||||-----||||-||-----|------||-- 104 [R] COG1266 Predicted metal-dependent membrane protease 6 13 19 31 |||---||-||-|---|---|-----------|--|||----|||||-||||-||||||-----|| 33 [I] COG1267 Phosphatidylglycerophosphatase A and related proteins 10 16 18 28 |-||--|||--------||||||-|-|---||||||||---------------------||||-|| 34 [R] COG1268 Uncharacterized conserved protein 9 17 19 24 ||||||||||||||||----||||||------||-------------------------------- 26 [C] COG1269 Archaeal/vacuolar-type H+-ATPase subunit I 8 19 23 30 |||||||||||||-----||||-----||-|----|-|--------|-||-----|---||||--- 31 [H] COG1270 Cobalamin biosynthesis protein CobD/CbiB 7 14 20 36 --||||--|-------|-||--||--|||--|--||||----|||||-||||---|--|||||||| 52 [C] COG1271 Cytochrome bd-type quinol oxidase, subunit 1 8 12 17 33 -------------|||----||--|||||-||||||||----|||||-||--|||----|||||-- 38 [R] COG1272 Predicted membrane protein, hemolysin III homolog 4 5 5 9 --------|------------------||-------||-----------|---------||-|--- 18 [S] COG1273 Uncharacterized conserved protein 6 7 7 13 ----||||---|----------|||-||||-------------------------|---------- 13 [C] COG1274 Phosphoenolpyruvate carboxykinase (GTP) 5 10 13 22 -|--|-|||----||-----------|||--||||-------|||-|-|-||-|------------ 29 [P] COG1275 Tellurite resistance protein and related permeases 4 6 6 13 ----------------|----|-------------|||----|||||--------|----|-|--- 13 [P] COG1276 Putative copper export protein 8 17 18 27 --|||||||--||----|||-|--||----|---|||||||--------|-----|----||---- 64 [R] COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component 8 11 19 37 ---|------------||--||----|||||||-||||----||||||||||||||---||||||| 127 [K] COG1278 Cold shock proteins 4 8 12 22 --------------------|-----|||-|---|-||----|||||-||-|---|||-|-|---| 25 [R] COG1279 Lysine efflux permease 8 15 22 32 |-|-||--|||||----||--|----|---------||----|||||-|||||--|--||||||-- 127 [E] COG1280 Putative threonine efflux protein 7 12 19 33 ----------------||||||--------||||||||-|--|||||-||||||||---|||||-- 34 [O] COG1281 Disulfide bond chaperones of the HSP33 family 3 6 12 24 ------------------||-------|||------------|||||-||||-|||---||||||| 26 [C] COG1282 NAD/NADP transhydrogenase beta subunit 5 8 11 21 --------------------|---|-|-----||||||-|--|||-|-||--------|||||--- 29 [P] COG1283 Na+/phosphate symporter 7 10 11 22 ---------|-------|--|-||-|----||||||||||||------|----------|||---- 50 [S] COG1284 Uncharacterized conserved protein 8 12 15 26 ----------------|-||||--|--||-||-|-|||----|||||--|||---|---|||---- 33 [S] COG1285 Uncharacterized membrane protein 3 6 14 32 ------------------------||-----|||||||----|||||-|||||||||||||||||| 32 [R] COG1286 Uncharacterized membrane protein, required for colicin V production 4 11 12 14 |||||||||-||-||-------------------------------------------|------- 26 [R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation 4 5 7 13 --------------------|----|------|||-||----|||-|---|------------|-- 19 [S] COG1288 Predicted membrane protein 4 7 12 23 ------------------|--|------------|||-----|||||-||||||||--|||||--- 55 [S] COG1289 Predicted membrane protein 9 14 21 33 ---|||----||||--|-||-|----||||------||----------||--|||||||||||||| 45 [C] COG1290 Cytochrome b subunit of the bc complex 5 9 12 24 ----------------||------||----|----|||----|||||-||-----|||||||||-- 28 [N] COG1291 Flagellar motor component 5 7 10 21 ---|--------------------|-|||-----||||----|||||-||||-||-----|----- 37 [M] COG1292 Choline-glycine betaine transporter 11 21 24 33 ||||||||||||||||-|||||---|----||||||||------------------|||------- 34 [K] COG1293 Predicted RNA-binding protein homologous to eukaryotic snRNP 7 12 18 33 --||------------|-||--||--|||--|--||||----|||||-||||---|--|||||||| 46 [C] COG1294 Cytochrome bd-type quinol oxidase, subunit 2 9 15 23 44 --|-------------|-||||||--||||||||||||-|--|||||-|||||||||||||||||| 63 [S] COG1295 Predicted membrane protein 6 10 15 29 --|-----|-----------||----|----|-|||||----|||||-||||-|||||-||||--- 35 [E] COG1296 Predicted branched-chain amino acid permease (azaleucine resistance) 4 8 11 13 ---|--|------|-------------||--------------------||-||||--|----|-- 14 [S] COG1297 Predicted membrane protein 6 10 13 27 ----------------||----||||----|----|||----||||||||-----|||||||||-- 31 [NU] COG1298 Flagellar biosynthesis pathway, component FlhA 6 9 13 24 --------------------||---||---||||||||-||||||||-|||----|---------- 52 [G] COG1299 Phosphotransferase system, fructose-specific IIC component 6 14 15 19 |||---||||--|-----||-------||-|---|-||-----------|------------||-- 23 [S] COG1300 Uncharacterized membrane protein 11 17 22 36 --||--||----|---|--||||||||||-|---|-||----|||||-||--|--|--|||-|||| 69 [C] COG1301 Na+/H+-dicarboxylate symporters 5 6 7 13 -----------------|--||||------||||||||---------------------------- 29 [S] COG1302 Uncharacterized protein conserved in bacteria 2 9 10 12 ||||||||||-||----------------------------------------------------- 12 [S] COG1303 Uncharacterized protein conserved in archaea 9 20 28 48 |||||||||||||||---||-|--||||||-||||||-----|||||-||||-||----||||||| 71 [C] COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases 9 17 21 29 |-|---||||||----||||-|-----||||----|||-----------||||--|---||-||-- 74 [E] COG1305 Transglutaminase-like enzymes, putative cysteine proteases 2 2 2 3 --------------------|---||---------------------------------------- 3 [S] COG1306 Uncharacterized conserved protein 6 8 9 19 -----------------|--||----|||-||||||||||||-------|---------------- 43 [S] COG1307 Uncharacterized protein conserved in bacteria 4 12 13 15 |||||||||||-||||-------------------------------------------------- 15 [K] COG1308 Transcription factor homologous to NACalpha-BTF3 10 20 27 44 |-||---||--|----||||||----|||||||||||||---|||||-||||||||--||||||-- 592 [K] COG1309 Transcriptional regulator 9 18 21 27 |-|||||||||||||||-||-|-----||--------------||||--|-----|---------- 56 [R] COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily 3 11 11 13 ||||||||||---|||-------------------------------------------------- 13 [L] COG1311 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B 4 6 8 17 ----||-----------|------------||----||----|||||---|--------||||--- 20 [G] COG1312 D-mannonate dehydratase 5 10 11 12 |||---|||||-|---||------------|----------------------------------- 13 [R] COG1313 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins 9 15 23 47 ----------------|-|||||||||||||||||||||-|-|||||||||||||||||||||||| 47 [U] COG1314 Preprotein translocase subunit SecG 4 5 5 6 -----------------|------||----|------|----------|----------------- 6 [L] COG1315 Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain 6 8 9 18 -----------------|||-|--||||||||||||||---------------------------- 46 [K] COG1316 Transcriptional regulator 5 9 11 21 -----------------|----||||----|-----||----||||||||-----||||---|--- 25 [NU] COG1317 Flagellar biosynthesis/type III secretory pathway protein 4 7 8 9 -|----|||||-|---||------------------------------------------------ 10 [K] COG1318 Predicted transcriptional regulators 6 8 11 18 ----------|||--------|--||-||-------||----|||----|-----|---||-|--- 38 [C] COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs 6 11 13 20 ||||--||---------|---|----|-------||||----------||---------|||--|| 29 [P] COG1320 Multisubunit Na+/H+ antiporter, MnhG subunit 9 18 22 36 |||||||||||||----|---||||-||||||||||||----|||-|-----|---------|--- 55 [K] COG1321 Mn-dependent transcriptional regulator 3 6 13 26 ----------------------||-------|||-----|--|||||-||||||||---||||||| 26 [S] COG1322 Uncharacterized protein conserved in bacteria 4 8 9 14 ||-------|-------|--|---------||||||||-|-------------------------- 16 [R] COG1323 Predicted nucleotidyltransferase 9 16 18 25 |-|-|||||||-|--|||-|-|-|------------------|||||-----|--|--------|| 25 [P] COG1324 Uncharacterized protein involved in tolerance to divalent cations 2 8 10 11 ||||--|||||||----------------------------------------------------- 12 [J] COG1325 Predicted exosome subunit 1 7 7 8 ||||--||||-------------------------------------------------------- 9 [R] COG1326 Uncharacterized archaeal Zn-finger protein 8 11 18 36 -----------------||-||||--||||||||||||----|||||-||||||||---|||||-- 36 [K] COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains 5 11 15 24 |||---||-|-------|--|---------||||||------|||||-||||---|---------- 27 [F] COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase 5 5 7 16 ---------------------|--||||||------||---------------------||||||| 17 [K] COG1329 Transcriptional regulators, similar to M. xanthus CarD 4 5 9 18 ----------------------||-|-||-------------|||||||||||||----------- 18 [L] COG1330 Exonuclease V gamma subunit 9 14 16 20 |-||||--|-|||---|--|-|||---||-|-----|------------------------||--- 24 [O] COG1331 Highly conserved protein containing a thioredoxin domain 3 7 7 8 |||--||----------|---------||------------------------------------- 8 [L] COG1332 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 5 6 7 12 ----------------|-||------||||------||---------------|||---------- 12 [O] COG1333 ResB protein required for cytochrome c biosynthesis 4 6 7 10 ----------------||------------|-----||----------||------|||------- 10 [N] COG1334 Uncharacterized flagellar protein FlaG 11 21 29 47 --|||||||||||||-||-|-|--|||||-||||||||----|||||-||--||||--||||||-- 126 [Q] COG1335 Amidases related to nicotinamidase 5 7 7 7 |-------||-|----||-------------------|---------------------------- 11 [L] COG1336 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 5 10 11 12 |||--||--|||-----|-|-------||------------------------------------- 17 [L] COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 6 10 13 27 ----------------||----||||----|----|||----||||||||-----|||||||||-- 29 [NU] COG1338 Flagellar biosynthesis pathway, component FliP 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [KH] COG1339 Transcriptional regulator of a riboflavin/FAD biosynthetic operon 2 8 10 12 |-|||||||||||----------------------------------------------------- 13 [S] COG1340 Uncharacterized archaeal coiled-coil protein 3 7 9 10 -|----|||||||||--------------------------------------------------- 12 [R] COG1341 Predicted GTPase or GTP-binding protein 3 7 7 8 |||---|||---------------------|-----------------|----------------- 10 [R] COG1342 Predicted DNA-binding proteins 7 12 14 15 |||--|--||||-----|-||------||---|----|---------------------------- 18 [L] COG1343 Uncharacterized protein predicted to be involved in DNA repair 5 9 12 24 ----------------||------||----|----|||----|||||-||-----|||||||||-- 81 [N] COG1344 Flagellin and related hook-associated proteins 5 8 10 19 ----------------||------||----|----|||----|||||-||-----||||------- 20 [N] COG1345 Flagellar capping protein 5 9 14 23 --|---||------------||--------||--|-||----|||||-||||-|||-----|---- 30 [M] COG1346 Putative effector of murein hydrolase 2 3 6 9 ----------------------||---------------------|--||||-||----------- 9 [C] COG1347 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD 5 9 9 10 |||------|--------|||---------|-----------------------------|-|--- 18 [P] COG1348 Nitrogenase subunit NifH (ATPase) 7 10 15 29 ----------------||--||----|---||||||||----|||||-||||-|||---||||--- 145 [KG] COG1349 Transcriptional regulators of sugar metabolism 4 8 10 12 |-|-|||||-|||---||------------------------------------------------ 15 [R] COG1350 Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) 10 14 16 26 ---|||||--|||---||||--|||||||||-------------------------|||-----|| 26 [F] COG1351 Predicted alternative thymidylate synthase 6 13 16 26 --||--|||--------|-|----||----|----|||----|||||-||-----|--|||-||-- 44 [NT] COG1352 Methylase of chemotaxis methyl-accepting proteins 6 12 13 14 |||--||-||||----||---------||--------|---------------------------- 18 [R] COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs) 10 20 24 41 -||||||||-------||||||--|-||||||||||||||||-------|--||||---|||||-- 42 [S] COG1354 Uncharacterized conserved protein 6 13 15 17 |||-|||||||||||-||--------------------------------------------|--- 18 [R] COG1355 Predicted dioxygenase 1 4 4 5 ||-|--||---------------------------------------------------------- 5 [S] COG1356 Uncharacterized protein conserved in archaea 7 11 16 27 --||--------------||-|--|-|||-||---|||----|||||--|-|-------||-|||| 105 [S] COG1357 Uncharacterized low-complexity proteins 7 16 19 26 ||||||||||||||||-|--|---------||||||||---------------------------- 41 [J] COG1358 Ribosomal protein HS6-type (S12/L30/L7a) 7 11 17 28 --||--------------|-||----|||-||-|-||-----|||||-||-|-|||---||-||-- 56 [S] COG1359 Uncharacterized conserved protein 5 9 12 24 ----------------||------||----|----|||----|||||-||-----|||||||||-- 45 [N] COG1360 Flagellar motor protein 3 8 9 11 -||||||||-||-----|------------------------------------------------ 31 [M] COG1361 S-layer domain 7 8 8 11 -------------||--|--|----||||||------------------|---------------- 14 [E] COG1362 Aspartyl aminopeptidase 8 17 20 30 ||||--|||||-|----|-|||--------||||||||||--|||-|--|----------|----- 56 [G] COG1363 Cellulase M and related proteins 9 18 21 31 |||-----||---||-||||-|----||||||--||||-----------|---|||---|||||-- 33 [E] COG1364 N-acetylglutamate synthase (N-acetylornithine aminotransferase) 1 4 4 5 ||----||-|-------------------------------------------------------- 5 [R] COG1365 Predicted ATPase (PP-loop superfamily) 9 12 14 20 -----------------||||||||--||-|---||||----------||---------||--|-- 69 [T] COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) 4 4 4 4 --------|-------||-------------------|---------------------------- 4 [L] COG1367 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 3 7 11 23 -----------------|------------|||-|||-----|||-|-||||-||-|||||-|--- 36 [M] COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily 3 10 11 12 ||||--||||-||||--------------------------------------------------- 12 [J] COG1369 RNase P/RNase MRP subunit POP5 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [O] COG1370 Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit 5 12 14 17 |||||||||||||---||---------||------------------------------------- 17 [S] COG1371 Uncharacterized conserved protein 8 12 12 16 -|--||||-|--||--|-||-|-----|||------|----------------------------- 77 [L] COG1372 Intein/homing endonuclease 7 12 15 19 -||-|-||--||-----|--|------||----|-|--------------|-----|||---|--| 53 [R] COG1373 Predicted ATPase (AAA+ superfamily) 4 8 8 9 -|----||||--||||-------------------------------------------------- 9 [J] COG1374 Protein involved in ribosomal biogenesis, contains PUA domain 5 9 12 23 -----------------|||------|||||-----||----|||-|-||---|||---||||--- 94 [S] COG1376 Uncharacterized protein conserved in bacteria 6 10 13 27 ----------------||----||||----|----|||----||||||||-----|||||||||-- 32 [NU] COG1377 Flagellar biosynthesis pathway, component FlhB 4 11 13 15 |||||||||||||--------|--------------|----------------------------- 36 [K] COG1378 Predicted transcriptional regulators 2 6 6 8 |||---||-|--------------------------||---------------------------- 9 [S] COG1379 Uncharacterized conserved protein 5 9 14 23 --|---||------------||--------||--|-||----|||||-||||-|||-----|---- 30 [R] COG1380 Putative effector of murein hydrolase LrgA 8 13 21 41 ------------------|||||||-||||||||||||||--|||||-||||||||---||||||| 41 [L] COG1381 Recombinational DNA repair protein (RecF pathway) 3 11 13 15 |||||||||||||||--------------------------------------------------- 17 [O] COG1382 Prefoldin, chaperonin cofactor 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG1383 Ribosomal protein S17E 4 11 13 18 ||||||||||--|-----------||-----------------------------------||||| 18 [J] COG1384 Lysyl-tRNA synthetase (class I) 9 15 23 46 ----------------||||||--||||||||||||||||--|||||||||||||||||||||||| 49 [S] COG1385 Uncharacterized protein conserved in bacteria 9 17 21 38 --|-|||||--------|||||--|-||||||||||||||||-------|--||||---|||||-- 43 [K] COG1386 Predicted transcriptional regulator containing the HTH domain 9 18 20 30 |||-||||||---||-||--||-----||-||--||||----|||||-|-----------|----- 40 [ER] COG1387 Histidinol phosphatase and related hydrolases of the PHP family 7 8 12 19 ----------------|----|||-||||-||--||||-------|--||||-------------- 43 [M] COG1388 FOG: LysM repeat 2 8 10 11 ||||--|||||||----------------------------------------------------- 11 [L] COG1389 DNA topoisomerase VI, subunit B 8 16 17 21 |||||||||||-||||----||||||---------------------------------------- 21 [C] COG1390 Archaeal/vacuolar-type H+-ATPase subunit E 3 5 10 22 ----------------|---------||||------------|||||-||||-|||---|||||-- 22 [OT] COG1391 Glutamine synthetase adenylyltransferase 7 14 16 23 |||---|||--|-----|---|||------|---|||-----------||||---|---||-|--- 28 [P] COG1392 Phosphate transport regulator (distant homolog of PhoU) 6 11 18 35 -------------------|||----|--||||||||||-|||||||-||||||||--||||||-- 75 [P] COG1393 Arsenate reductase and related proteins, glutaredoxin family 9 17 19 24 ||||||||||||||||----||||||------||-------------------------------- 25 [C] COG1394 Archaeal/vacuolar-type H+-ATPase subunit D 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [K] COG1395 Predicted transcriptional regulator 11 15 23 40 |-|-------|-----||-|||--|-|||-||||||||----|||||-||||||||---||||||| 387 [K] COG1396 Predicted transcriptional regulators 6 10 10 13 -||-----|-------|--|-|--------|--|--------|||-|---------------|--- 15 [O] COG1397 ADP-ribosylglycohydrolase 3 7 7 8 -------------||---||-----------------------------|-----|--------|| 10 [I] COG1398 Fatty-acid desaturase 7 10 16 30 ----------------||||-|----||||||||||||----|||||-||||||||---------- 30 [R] COG1399 Predicted metal-binding, possibly nucleic acid-binding protein 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [U] COG1400 Signal recognition particle 19 kDa protein 7 10 12 15 |-|---|---||----|-|--|-----------|--|-----|--|----------|||------- 16 [V] COG1401 GTPase subunit of restriction endonuclease 7 11 14 19 ||-|-----||||----|||-------||------|-|---------------------|||||-- 24 [R] COG1402 Uncharacterized protein, putative amidase 6 10 14 24 ---|--------------||-|-----||||||-|||-----|||---|---|--|---|||||-- 58 [V] COG1403 Restriction endonuclease 11 20 26 35 --||----|-|-|||||-||||----|||||-||--||||------|-||--||||--|||-|--- 105 [O] COG1404 Subtilisin-like serine proteases 4 12 14 16 ||||||||||||||||-------------------------------------------------- 39 [K] COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB 4 5 5 6 -----------------|------||----|------|----------|----------------- 6 [N] COG1406 Predicted inhibitor of MCP methylation, homolog of CheC 3 10 13 18 |||||||||||||----------------------------------------------|||||-- 22 [R] COG1407 Predicted ICC-like phosphoesterases 9 14 15 24 |-|-------|-----|--|-|||--||||||---|||----|------------||||-|-|--- 30 [R] COG1408 Predicted phosphohydrolases 9 18 24 39 |-|---|||||-|||-|-||--||--||||||--|||-----|||||-||||---|---|||||-- 75 [R] COG1409 Predicted phosphohydrolases 6 10 15 25 -----------------|||-|----|||||------|----|||||-|||-|--|---|||||-- 28 [E] COG1410 Methionine synthase I, cobalamin-binding domain 1 5 5 5 |||-----||-------------------------------------------------------- 5 [R] COG1411 Uncharacterized protein related to proFAR isomerase (HisA) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [R] COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily 8 13 14 19 |-||---------|||--||--||||--------|-||----||-----|------------|--- 54 [C] COG1413 FOG: HEAT repeat 7 10 14 25 ---|------------||---|----|||-------||----|||||-||||---|--||||||-- 99 [K] COG1414 Transcriptional regulator 3 7 9 12 |---|||||||||-----------------------------------------------|-|--- 13 [S] COG1415 Uncharacterized conserved protein 4 8 8 9 |--|||--|-------|----|---------------------------------|------|--- 10 [S] COG1416 Uncharacterized conserved protein 1 4 4 4 ||------||-------------------------------------------------------- 9 [S] COG1417 Uncharacterized conserved protein 8 19 20 36 ||||||||||------||--||--||----|||||||||-|||||-|---------|||||----- 51 [R] COG1418 Predicted HD superfamily hydrolase 5 8 9 14 ----------------||------||----|----|||----------||-----||||------- 14 [N] COG1419 Flagellar GTP-binding protein 7 13 15 32 -----------------||||-||--||||||||||||||||----------|--|||||||||-- 32 [K] COG1420 Transcriptional regulator of heat shock gene 2 6 6 6 ||---||--|-------|------------------------------------------------ 6 [L] COG1421 Uncharacterized protein predicted to be involved in DNA repair 1 8 8 10 ||||||||||-------------------------------------------------------- 11 [S] COG1422 Predicted membrane protein 3 8 8 9 |||---||||--|---|------------------------------------------------- 9 [L] COG1423 ATP-dependent DNA ligase, homolog of eukaryotic ligase III 3 3 3 4 -|--------------|-----------------|-|----------------------------- 4 [H] COG1424 Pimeloyl-CoA synthetase 6 8 13 26 -----------------|-|--||||-----|||||||----|||||-|||||--|--------|| 27 [S] COG1426 Uncharacterized protein conserved in bacteria 7 8 9 13 ----||--|-|-|---|----|||-------------|------------------|||------- 13 [R] COG1427 Predicted periplasmic solute-binding protein 4 5 6 12 ---------------------|---|-----||-|||-||||-------------|---------- 16 [F] COG1428 Deoxynucleoside kinases 4 11 11 15 ||||-----|--------||-------||--------------------|-----|---||||--- 48 [H] COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases 6 13 14 19 ||-|--||-||------|||----||--------------------------|--|---|||||-- 21 [S] COG1430 Uncharacterized conserved protein 2 4 4 4 -|------||------|------------------------------------------------- 4 [J] COG1431 Uncharacterized protein containing piwi/argonaute domain 7 17 19 25 ||||--||||------|-||-|--|-|---------------------||----|-||||||||-- 41 [S] COG1432 Uncharacterized conserved protein 5 11 11 13 |||-|||||||------|------------|-----------------|----------------- 28 [S] COG1433 Uncharacterized conserved protein 7 11 19 30 ----------------||||-|----|---||--||------|||||-||||||||---||||||| 58 [S] COG1434 Uncharacterized conserved protein 8 12 15 30 ---||-----|----|-|---|---|----|||||||||||||||||-|-||-------||-|--- 30 [F] COG1435 Thymidine kinase 8 16 18 20 ||||||||||||||||----||--|--------|-------------------------------- 20 [C] COG1436 Archaeal/vacuolar-type H+-ATPase subunit F 5 12 14 15 ||||--|||||||------------|----|--------------|---------|---------- 17 [F] COG1437 Adenylate cyclase, class 2 (thermophilic) 6 7 10 23 -----------------|---|-|--||||||||||||----|||||-|-||-------------- 30 [K] COG1438 Arginine repressor 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [R] COG1439 Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module 3 4 6 14 -------------------------|----||||-|||----|||||-|----------------- 28 [G] COG1440 Phosphotransferase system cellobiose-specific component IIB 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [H] COG1441 O-succinylbenzoate synthase 2 4 7 13 ---------------------------------|--|-----|||-|---||----||--|---|| 30 [M] COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases 5 6 6 11 ---|---------|||----------|||-------------|||-|------------------- 11 [I] COG1443 Isopentenyldiphosphate isomerase 5 9 13 19 ---|--||||||||||--------------------------|||||-|-||-------------- 23 [R] COG1444 Predicted P-loop ATPase fused to an acetyltransferase 6 9 13 25 --------------------||---||---||||||||-||||||||-||||---|---------- 55 [G] COG1445 Phosphotransferase system fructose-specific component IIB 5 10 13 18 ---|||||--||--|---||----------------------|||-|-|------|---|---|-- 21 [E] COG1446 Asparaginase 3 4 6 15 -------------------------|----||||||||----|||||-|----------------- 31 [G] COG1447 Phosphotransferase system cellobiose-specific component IIA 4 7 12 20 -------------||-----|-||------------------|||||-||||||||----|-|--- 31 [E] COG1448 Aspartate/tyrosine/aromatic aminotransferase 5 9 10 12 -||-||||--||----|-||----|----------------------------------------- 19 [G] COG1449 Alpha-amylase/alpha-mannosidase 4 7 11 16 ----------------|---|-||------------------|||||-||--|--|--|---||-- 30 [NU] COG1450 Type II secretory pathway, component PulD 7 16 22 34 ||||--|||-------|---||----|---|-------||--|||||-||--||||||||||||-| 43 [R] COG1451 Predicted metal-dependent hydrolase 3 6 13 26 ----------------|-------||----------------|||||-|||||||||||||||||| 27 [M] COG1452 Organic solvent tolerance protein OstA 4 6 6 6 |-|--------------|||----------|----------------------------------- 16 [R] COG1453 Predicted oxidoreductases of the aldo/keto reductase family 9 18 23 36 |-|||||||--||||-||--|-----|---||-|||||----|||||-||-|---|---||||--- 73 [C] COG1454 Alcohol dehydrogenase, class IV 3 4 6 15 -------------------------|----||||||||----|||||-|----------------- 37 [G] COG1455 Phosphotransferase system cellobiose-specific component IIC 1 5 5 5 |||-----||-------------------------------------------------------- 6 [C] COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) 5 7 9 17 ----||||---|-|---------------------|||----|||-|--|-|-||----------- 24 [F] COG1457 Purine-cytosine permease and related proteins 3 8 8 9 |||---||||--|---|------------------------------------------------- 9 [R] COG1458 Predicted DNA-binding protein containing PIN domain 8 12 19 31 ----------------||||||||------||||||||----|||||-||||||||------||-- 45 [NU] COG1459 Type II secretory pathway, component PulF 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [S] COG1460 DNA-directed RNA polymerase, subunit F 5 7 8 18 -----------------|--||----|||-||||||||||||------------------------ 22 [R] COG1461 Predicted kinase related to dihydroxyacetone kinase 4 7 9 14 ----------------|-||-|--------------------|||||--|---|||-------|-- 16 [M] COG1462 Uncharacterized protein involved in formation of curli polymers 4 8 15 29 ----------------|-||-------|||------------|||||-|||||||||||||||||| 87 [Q] COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component 7 11 18 34 --------------------||-||-|---||||||||----|||||-||||||||||||||||-- 53 [P] COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen 2 7 7 7 ||||----||------|------------------------------------------------- 7 [E] COG1465 Predicted alternative 3-dehydroquinate synthase 9 15 23 49 ----------------||||-||||||||||||||||||||||||||||||||||||||||||||| 50 [L] COG1466 DNA polymerase III, delta subunit 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [L] COG1467 Eukaryotic-type DNA primase, catalytic (small) subunit 7 11 14 15 |||---|||-|||---||-||-----------|----|---------------------------- 23 [L] COG1468 RecB family exonuclease 5 13 15 20 ||||||||||--|----|----------------|-||-----------|--||||---------- 20 [S] COG1469 Uncharacterized conserved protein 2 4 4 5 --|---|||----------------------------|---------------------------- 6 [S] COG1470 Predicted membrane protein 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [J] COG1471 Ribosomal protein S4E 9 13 21 36 -----------|--|--|||-|---|||||||---|||----|||||-||||||||---||||||| 62 [G] COG1472 Beta-glucosidase-related glycosidases 9 17 21 35 --||||||---|-----|||||----|||-||-|||||----|||----|||---|--||||||-- 89 [R] COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase 4 10 12 14 |-|||||||-||||||-------------------------------------------------- 41 [LO] COG1474 Cdc6-related protein, AAA superfamily ATPase 10 18 27 49 ||-|--|||-|||---|--|-|||||||||||||||||----|||||-||--|||||||||||||| 111 [K] COG1475 Predicted transcriptional regulators 5 12 13 18 ||||---||----------|-|--------||||||||-----------|-------------|-- 34 [K] COG1476 Predicted transcriptional regulators 9 12 19 30 --|-------------||--|||||-----||||-|------|||||-||||||||----||||-- 35 [H] COG1477 Membrane-associated lipoprotein involved in thiamine biosynthesis 4 9 9 12 ||||----||------------||---|||--|--------------------------------- 13 [S] COG1478 Uncharacterized conserved protein 7 14 16 21 -|||--|----------|-||-----|---|----|--||---|||--|--|--|-|||------- 58 [S] COG1479 Uncharacterized conserved protein 6 8 8 10 -----------------||||--||-----|----|||---------------------------- 10 [R] COG1480 Predicted membrane-associated HD superfamily hydrolase 4 6 7 18 -----------------|--|-----||||||||||||||||------------------------ 18 [S] COG1481 Uncharacterized protein conserved in bacteria 8 11 14 26 --------|----||--|---|---|||||||||||||-|--|||||-|--|-------------- 30 [G] COG1482 Phosphomannose isomerase 4 6 6 7 ------||||--|----|------------------------------------------|----- 9 [R] COG1483 Predicted ATPase (AAA+ superfamily) 5 9 10 23 --|-------------|----------||-|||||||||---||||||-------|---||-|--- 125 [L] COG1484 DNA replication protein 4 7 13 23 -------------||------|-----||-------------|||||-||--||||---||||||| 25 [R] COG1485 Predicted ATPase 3 5 6 14 -----------------|------------|----|||----|||||-|----------||-|--- 37 [G] COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases 6 12 17 21 -||---|||-||------||-|-----||-----------------|---|-|--|---||-||-| 84 [R] COG1487 Predicted nucleic acid-binding protein, contains PIN domain 12 24 32 54 --|||||||||||||-||||||--|||||-||||||||||||||||||||-|||||--|||||--- 60 [H] COG1488 Nicotinic acid phosphoribosyltransferase 7 12 18 26 |---||--|-|||---||||----------|------|----|||||-||||-------|||-|-- 26 [R] COG1489 DNA-binding protein, stimulates sugar fermentation 8 11 16 29 -------------||-||--||----|||-||||||||----|||||-||||-|||---------- 29 [J] COG1490 D-Tyr-tRNAtyr deacylase 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [J] COG1491 Predicted RNA-binding protein 8 18 21 27 ||||||--||-|------||||-----||-|----|-|--------|-||-----|---|||||-- 31 [H] COG1492 Cobyric acid synthase 5 9 12 24 ---------|----------|---|-----||||||||||||----------||||---|||||-- 24 [T] COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism 7 10 13 22 --|---------------||||----|||||-----||----|||-|-|-||---------|||-- 26 [G] COG1494 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins 4 7 14 28 ---------------------|||------------||----|||||-|||||||||||||||||| 35 [O] COG1495 Disulfide bond formation protein DsbB 9 14 21 37 ----------------|-||||||-||||||---|-||----|||||-||||||||--|||||||| 39 [S] COG1496 Uncharacterized conserved protein 1 7 7 8 ||||||--||-------------------------------------------------------- 8 [K] COG1497 Predicted transcriptional regulator 4 12 14 16 ||||||||||||||||-------------------------------------------------- 21 [J] COG1498 Protein implicated in ribosomal biogenesis, Nop56p homolog 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [J] COG1499 NMD protein affecting ribosome stability and mRNA decay 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG1500 Predicted exosome subunit 7 11 14 21 ----||----||-||--|-|----------||-|-|-|----|||||--------|---|---|-- 37 [G] COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases 11 19 27 47 ----||--|-|--|||-||||-||--|---||||||||||--||||||||||||||||-||||||| 104 [I] COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes 5 13 15 17 |||||||||||||||||------------------------------------------------- 20 [J] COG1503 Peptide chain release factor 1 (eRF1) 1 5 5 6 |-|---||||-------------------------------------------------------- 7 [S] COG1504 Uncharacterized conserved protein 5 6 8 13 ------||-----------|-|----|||------------------------||-------|||| 17 [E] COG1505 Serine proteases of the peptidase family S9A 8 12 17 21 ---|||||--|||||---|-||------------|-||-----------|--|------|---|-| 48 [E] COG1506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases 3 3 3 6 ----------------||--------||||------------------------------------ 6 [S] COG1507 Uncharacterized conserved protein 5 9 14 28 ----------------|-----||||----|----|||----|||||-||--||||||||||||-- 30 [K] COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog 8 10 14 22 -||-------------||--||--|-----------||----|||||-|-|||------||-||-- 25 [E] COG1509 Lysine 2,3-aminomutase 3 5 5 8 -|----||--------------------------|-|------------------|---|-|---- 11 [K] COG1510 Predicted transcriptional regulators 4 5 6 14 |--------------------|----||||||||||||---------------------------- 27 [S] COG1511 Predicted membrane protein 5 8 12 16 -----------------|||----|------|----||----|||----|-|---|-----|||-- 23 [R] COG1512 Beta-propeller domains of methanol dehydrogenase type 3 5 6 8 ----------------|-||----------------------|||----|-----|---------- 8 [P] COG1513 Cyanate lyase 9 18 22 33 |||-|||||||||---||-|-|----|---|---|-||----|||||--|-----|---|||||-- 38 [J] COG1514 2'-5' RNA ligase 9 14 17 23 ---||||||||||-|-||-|-|--------|-----|-----|||||-----|------------- 23 [L] COG1515 Deoxyinosine 3'endonuclease (endonuclease V) 5 8 10 19 ----------------||------||----|----|||----|||||-||-----||||------- 21 [NUO] COG1516 Flagellin-specific chaperone FliS 3 5 6 6 -|---||---||----|------------------------------------------------- 12 [L] COG1517 Uncharacterized protein predicted to be involved in DNA repair 9 17 21 28 |||-|||-|||||---||-||------||---|--|-|----|||||----|--|---|------- 36 [L] COG1518 Uncharacterized protein predicted to be involved in DNA repair 4 7 14 27 ----------------|---|-||------------------|||||-|||||||||||||||||| 27 [M] COG1519 3-deoxy-D-manno-octulosonic-acid transferase 7 14 18 26 ||||--|||--------|---|---|-|||------|-----|||||-||--|--|-------||| 66 [S] COG1520 FOG: WD40-like repeat 9 15 17 25 ----------------||||||--||-||||----|||-|---------|--|||||||----|-- 25 [K] COG1521 Putative transcriptional regulator, homolog of Bvg accessory factor 6 16 23 37 |||||||||||||--------|----|||-|-----||----|||||-||||-|||---|||||-- 250 [K] COG1522 Transcriptional regulators 10 14 18 30 --|--------|-----||-||||--|||-|-||--||-|--|||||-||||---|---||-|--- 36 [G] COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases 9 15 17 21 ----|||||--|-|||-|-|------|---|----|-|-----------|--|-----|-|-||-- 34 [R] COG1524 Uncharacterized proteins of the AP superfamily 7 16 17 26 ||-|--||-|---||-|--|------|-------|-|--|||-------|||-||---|||||--- 50 [L] COG1525 Micrococcal nuclease (thermonuclease) homologs 5 12 17 31 |||-||--|-||--------------|||-----||||----|||||-||||---|--||||||-- 32 [C] COG1526 Uncharacterized protein required for formate dehydrogenase activity 7 15 15 18 |||||||||||--|||----||----------||-------------------------------- 18 [C] COG1527 Archaeal/vacuolar-type H+-ATPase subunit C 6 11 13 23 |-|-----|------|-|--------|||-|---|--||---|||||-|-||----|||------- 29 [P] COG1528 Ferritin-like protein 7 9 13 19 ----------|||---|----|--|--||-------||----|||----|-----|---||-||-- 60 [C] COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs 10 16 25 42 ---|--||-||||---|||||-||--|||||----|-|----||||||||||||||---||||||| 56 [J] COG1530 Ribonucleases G and E 2 6 8 8 ||-----||||||----------------------------------------------------- 8 [S] COG1531 Uncharacterized protein conserved in archaea 1 4 4 4 ||------||-------------------------------------------------------- 4 [R] COG1532 Predicted RNA-binding protein 8 16 20 26 -||-|-|||||||----||-|------||-|-----||-----------|-----|---|||||-| 36 [L] COG1533 DNA repair photolyase 5 13 20 32 ||||--||||-||-------|---------||||||||----|||||-||||||||---------- 32 [J] COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein 3 4 6 9 -----------------|------------------|-----|||-|-||-----------|---- 10 [Q] COG1535 Isochorismate hydrolase 6 10 13 27 ----------------||----||||----|----|||----||||||||-----|||||||||-- 30 [N] COG1536 Flagellar motor switch protein 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [R] COG1537 Predicted RNA-binding proteins 4 8 15 27 ----------------|-|||---------------------|||||-|||||||||||||||||| 113 [MU] COG1538 Outer membrane protein 8 14 21 41 -------------||---||||||--||||||||||||----|||||-||||||||||||||||-- 47 [H] COG1539 Dihydroneopterin aldolase 6 9 13 22 ------||------------||----|--|----|-||----|||||-|||--|||--||------ 26 [R] COG1540 Uncharacterized proteins, homologs of lactam utilization protein B 7 10 12 13 |-|-----|--|-------|||---------------|----|--|--|---|--|---------- 23 [H] COG1541 Coenzyme F390 synthetase 3 4 4 4 -|-------|------||------------------------------------------------ 4 [S] COG1542 Uncharacterized conserved protein 5 7 7 10 ------||----------||----|--||||------|---------------------------- 11 [S] COG1543 Uncharacterized conserved protein 10 14 21 38 ----------------||||||-|-|||||||||||||----|||||-|||||--|---||||||| 43 [J] COG1544 Ribosome-associated protein Y (PSrp-1) 4 11 13 16 |||||||||||||--------------||----------------------------------|-- 48 [R] COG1545 Predicted nucleic-acid-binding protein containing a Zn-ribbon 9 15 21 40 ---|------------||||||----|||||-||-||||||||||||-||--||||||||||||-- 46 [R] COG1546 Uncharacterized protein (competence- and mitomycin-induced) 6 8 10 13 ---|||----|||---|-||-|------------|-||---------------------------- 13 [S] COG1547 Uncharacterized conserved protein 1 5 5 5 |||-----||-------------------------------------------------------- 5 [KG] COG1548 Predicted transcriptional regulator/sugar kinase 2 9 9 11 ||||||||||-|------------------------------------------------------ 12 [J] COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain 4 5 5 9 -----------------|---|-----||||----|||---------------------------- 9 [S] COG1550 Uncharacterized protein conserved in bacteria 4 6 10 20 -----------------|------||----|-----||----|||||||||||---|||------- 20 [T] COG1551 Carbon storage regulator (could also regulate swarming and quorum sensing) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG1552 Ribosomal protein L40E 3 6 9 15 |||------|-------|------------------------||||||||||-------------- 21 [P] COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction 6 9 10 16 ------|------|-----|-------|||||---||--|--|||--------||----------- 22 [G] COG1554 Trehalose and maltose hydrolases (possible phosphorylases) 8 12 18 31 --|--------------|||||----|||-||||||||----|||||-||||||||--|------- 40 [L] COG1555 DNA uptake protein and related DNA-binding proteins 5 8 11 17 ---|----|-----------||---------|----||----|||------|-||||||------- 17 [S] COG1556 Uncharacterized conserved protein 5 9 12 25 ----------------||------||----|----|||----||||||||-----|||||||||-- 26 [N] COG1558 Flagellar basal body rod protein 7 11 19 39 ----------------|---||--||||||||||-|||----|||||-|||||||||||||||||| 39 [R] COG1559 Predicted periplasmic solute-binding protein 4 7 14 30 --------------------|-||--||||------------|||||-|||||||||||||||||| 48 [M] COG1560 Lauroyl/myristoyl acyltransferase 6 9 15 26 ----------------||--|----|----|----|||----|||||-||||||||---|||||-- 27 [S] COG1561 Uncharacterized stress-induced protein 8 13 15 22 |--|-------|-||---||-|----|||-----|-|---------------||||---|||||-- 30 [I] COG1562 Phytoene/squalene synthetase 4 7 7 8 ||----|----------|||--------------------------------------------|| 9 [P] COG1563 Predicted subunit of the Multisubunit Na+/H+ antiporter 7 10 11 19 -------------||--|--||--|-----|||||||-------------------||-||||--- 19 [H] COG1564 Thiamine pyrophosphokinase 3 7 10 17 ----------------|-||--------------------------------|||||||||||||| 17 [S] COG1565 Uncharacterized conserved protein 3 5 11 21 ----------------|-----------------|-|-----|||||-|||--|||---||||||| 66 [V] COG1566 Multidrug resistance efflux pump 3 7 7 8 |||--||----------|---------||------------------------------------- 8 [L] COG1567 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 2 4 4 5 -|----|||-------|------------------------------------------------- 6 [R] COG1568 Predicted methyltransferases 3 6 6 7 -|----|||---------||--------------------------------|------------- 10 [R] COG1569 Predicted nucleic acid-binding protein, contains PIN domain 8 12 20 41 -----------------|-|||||--||||||||||||----|||||-|||||||||||||||||| 42 [L] COG1570 Exonuclease VII, large subunit 2 9 11 13 |||||||||||||----------------------------------------------------- 17 [R] COG1571 Predicted DNA-binding protein containing a Zn-ribbon domain 2 5 5 6 |-|---|||----------|---------------------------------------------- 9 [S] COG1572 Uncharacterized conserved protein 11 20 26 39 --|||||||-|||---||||||--|--|||||||--------------|-|--||||||||||||| 59 [L] COG1573 Uracil-DNA glycosylase 9 14 16 24 --||||||----|---||--||-----||------|||--------|--|-----|---|||||-- 33 [R] COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold 7 8 11 21 ---|-------------||||-----||||-|--|||-----|||||-|-||-------------- 24 [H] COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase 5 10 17 34 -----------------|--||--------||||||||||--|||||-||||||||||||||||-- 34 [S] COG1576 Uncharacterized conserved protein 6 13 16 20 ||||--||||||||||---------|-----|||||------------------------------ 25 [I] COG1577 Mevalonate kinase 4 9 9 10 |||---|||||-----||------------------------------------------------ 10 [S] COG1578 Uncharacterized conserved protein 7 7 7 13 ----------------|----|||||||-||-------------------------|||------- 13 [R] COG1579 Zn-ribbon protein, possibly nucleic acid-binding 5 8 10 18 ----------------||------||----|-----||----|||||-||-----||||------- 21 [N] COG1580 Flagellar basal body-associated protein 2 7 9 11 ||--|||||||||----------------------------------------------------- 15 [K] COG1581 Archaeal DNA-binding protein 3 4 4 6 -----------------|------||----|-----||---------------------------- 6 [N] COG1582 Uncharacterized protein, possibly involved in motility 3 8 8 9 |||--||||-------||------------------------------------------------ 14 [L] COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 4 7 9 14 |-|-||-----|-||---------------------------|||||-|--|-------------- 18 [S] COG1584 Predicted membrane protein 9 15 22 33 ||-|--||-||||----|||||----|||||-----------|||||-||-||------|||||-- 35 [OU] COG1585 Membrane protein implicated in regulation of membrane protease activity 6 11 15 23 -|--|||||-|||---||------------|-----||----||||||-|--|--|---------- 28 [E] COG1586 S-adenosylmethionine decarboxylase 11 23 29 47 ||||||--||||-||-|-||||||--|||||---||||----|||||-||-||||||||||||--- 57 [H] COG1587 Uroporphyrinogen-III synthase 2 9 9 11 ||||||||||--|----------------------------------------------------- 12 [J] COG1588 RNase P/RNase MRP subunit p29 6 10 18 37 ------------------||-|--||||||||||||||----|||||-||||||||---||||||| 37 [M] COG1589 Cell division septal protein 3 7 9 10 -|----|||||||||--------------------------------------------------- 12 [S] COG1590 Uncharacterized conserved protein 2 7 9 10 ||-|--|||||||----------------------------------------------------- 11 [L] COG1591 Holliday junction resolvase - archaeal type 7 13 13 13 |||----|||-|-----|-||---------|-----|---------------------|------- 28 [C] COG1592 Rubrerythrin 6 7 11 15 -----------------|--|---|-|----------|----|--||-||||-------||--|-- 48 [G] COG1593 TRAP-type C4-dicarboxylate transport system, large permease component 4 11 13 15 |||||||||-||||||-------------------------------------------------- 29 [K] COG1594 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS 8 12 19 34 -----------------|||||--|-||||||--||||----|||||-||||||||---|||||-- 172 [K] COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog 4 8 14 21 ----------------||||----------------------|||-|-||-|||||--||||||-- 41 [M] COG1596 Periplasmic protein involved in polysaccharide export 8 12 15 28 ----|--------||--|||-|----|||-||||||||----|||||--|---------||-||-- 46 [IR] COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase 5 13 15 19 |-|||---|--------|||-------------|--------||||--------|--|--|-||-| 43 [S] COG1598 Uncharacterized conserved protein 4 12 13 15 ||||||||||-|||||-------------------------------------------------- 26 [L] COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins 5 11 15 25 |-|-----|---------||-|--------|-|-||||----|||||-||-----|---|||||-- 31 [C] COG1600 Uncharacterized Fe-S protein 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [J] COG1601 Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain 2 8 10 12 |-|||||||||||----------------------------------------------------- 17 [S] COG1602 Uncharacterized conserved protein 3 10 11 12 ||||--||||-||||--------------------------------------------------- 12 [J] COG1603 RNase P/RNase MRP subunit p30 5 6 6 6 --------||-|----||-------------------|---------------------------- 7 [L] COG1604 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 10 21 30 51 ||||||--|||||||-||--||----||||||||||||----||||||||||||||||||||||-- 68 [E] COG1605 Chorismate mutase 4 9 9 9 |||-----||-------|||----------|----------------------------------- 11 [R] COG1606 ATP-utilizing enzymes of the PP-loop superfamily 7 11 18 35 ---|||----|||--------|||--|-------||||----||||||||||-|||||||||||-- 49 [I] COG1607 Acyl-CoA hydrolase 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [R] COG1608 Predicted archaeal kinase 6 10 16 31 -----------------|--||----|||-||||||||-|--|||||-|||||--|---|||||-- 277 [K] COG1609 Transcriptional regulators 5 9 12 20 -------------|---|--------|||-|----|||----------||--||||--|||||--- 20 [S] COG1610 Uncharacterized conserved protein 12 19 27 43 --|-||||||||-|--||-|||||--||||-|--|-||----|||||-||-|||||--||||||-- 56 [R] COG1611 Predicted Rossmann fold nucleotide-binding protein 9 13 16 26 ---|--------|||-|-||-|----||||----||||-----------|--|--|---||||||| 27 [O] COG1612 Uncharacterized protein required for cytochrome oxidase assembly 4 7 11 21 ------------------||-------|||-------|----|||||--|--||||---|||||-- 23 [P] COG1613 ABC-type sulfate transport system, periplasmic component 1 5 5 5 |||-----||-------------------------------------------------------- 7 [C] COG1614 CO dehydrogenase/acetyl-CoA synthase beta subunit 4 5 5 8 --------|---------||------|||||----------------------------------- 11 [S] COG1615 Uncharacterized conserved protein 1 6 6 7 |||---||||-------------------------------------------------------- 7 [S] COG1617 Uncharacterized conserved protein 4 10 12 14 |||-|||||||||---||------------------------------------------------ 14 [F] COG1618 Predicted nucleotide kinase 7 12 16 25 ----||------------||||--|-----||-|-|||-|--|||-|-||---|||--------|| 31 [V] COG1619 Uncharacterized proteins, homologs of microcin C7 resistance protein MccF 6 11 15 24 ---|----||-|---------|---|--------|-||----|||-|-||||-||||||--|---- 34 [C] COG1620 L-lactate permease 5 9 12 16 -------------||--|--------|---|-|||-||-----||---|--|---|---|------ 23 [G] COG1621 Beta-fructosidases (levanase/invertase) 9 13 19 34 ---|----|-||||--|-||-|----||||----||||----||||||-|--|--|---||||||| 60 [C] COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2 4 5 5 8 -----------------|--|-----|||-|-----||---------------------------- 8 [R] COG1623 Predicted nucleic-acid-binding protein (contains the HHH domain) 7 15 16 26 -|||--||||------|-||-|||||----||||||||-|||------------------------ 27 [S] COG1624 Uncharacterized conserved protein 4 9 9 10 |||---||-|--------||-|--------|----------------------------------- 12 [C] COG1625 Fe-S oxidoreductase, related to NifB/MoaA family 5 7 8 12 -------------|||---|----||----------------|||-|--|-----|---------- 17 [G] COG1626 Neutral trehalase 1 4 4 5 ||----||-|-------------------------------------------------------- 5 [S] COG1627 Uncharacterized protein conserved in archaea 3 10 12 14 |||||||||||||--------|-------------------------------------------- 14 [S] COG1628 Uncharacterized conserved protein 4 8 14 25 ----------------|-|||---------------------|||||-||||||||||||||||-- 242 [P] COG1629 Outer membrane receptor proteins, mostly Fe transport 2 6 7 9 ||--|||||--||----------------------------------------------------- 10 [S] COG1630 Uncharacterized protein conserved in archaea 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [J] COG1631 Ribosomal protein L44E 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [J] COG1632 Ribosomal protein L15E 6 9 9 14 |-|---||---|----||------------|-----||---------------------||||--- 25 [S] COG1633 Uncharacterized conserved protein 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [R] COG1634 Uncharacterized Rossmann fold enzyme 4 11 13 14 ||||--|||||||||--|------------------------------------------------ 14 [H] COG1635 Flavoprotein involved in thiazole biosynthesis 5 9 11 17 ----------------||--|---------|||-|---------------|||||-|||-----|| 17 [S] COG1636 Uncharacterized protein conserved in bacteria 4 8 10 14 ||-|--||-||||------|------||||------------------------------------ 15 [L] COG1637 Predicted nuclease of the RecB family 7 9 13 19 -----------------||-|---|-|---------||----|--||-||||---|---||-||-- 53 [G] COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component 3 4 5 5 -----------------|------|-----------------------||--------|------- 10 [T] COG1639 Predicted signal transduction protein 10 12 15 25 ----------|-----|-||||||-||||--|||--------|||||-||||---|---------- 26 [G] COG1640 4-alpha-glucanotransferase 5 10 10 10 |||-----||-------|||------|---|----------------------------------- 12 [S] COG1641 Uncharacterized conserved protein 6 9 15 25 -------------|||-----|--|||---------------|||||-||||||||---|||||-- 54 [L] COG1643 HrpA-like helicases 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [K] COG1644 DNA-directed RNA polymerase, subunit N (RpoN/RPB10) 2 7 9 10 -|||--|||||||----------------------------------------------------- 10 [R] COG1645 Uncharacterized Zn-finger containing protein 3 10 12 17 |||||||||||||---------------------||||---------------------------- 18 [R] COG1646 Predicted phosphate-binding enzymes, TIM-barrel fold 3 3 3 6 -----------------|------|---------||||---------------------------- 9 [R] COG1647 Esterase/lipase 8 18 23 37 ||||||--|||-|||-|---|------||-|---||||----||||||||--|||----|||||-- 43 [H] COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) 4 7 7 10 ------------------||-|--------------|-----||||---------|-----|---- 18 [S] COG1649 Uncharacterized protein conserved in bacteria 2 8 10 12 -||||||||||||----------------------------------------------------- 12 [S] COG1650 Uncharacterized protein conserved in archaea 9 14 21 39 ---|----|-|-----|-||-|||--||||----|||-----|||||-|||||||||||||||||| 65 [O] COG1651 Protein-disulfide isomerase 5 7 13 22 -------------------|-|--||---------||-----|||-|-||-|||||---|||||-- 31 [S] COG1652 Uncharacterized protein containing LysM domain 9 15 22 38 ---|||||--|||----|||-|--|-||||||||-|||----|||||-||-||--|---||||--- 209 [G] COG1653 ABC-type sugar transport system, periplasmic component 4 8 13 23 --||---||------------|--------||||||||----|||||-|||||------------- 23 [K] COG1654 Biotin operon repressor 3 3 3 4 -----------------|------||----|----------------------------------- 4 [S] COG1655 Uncharacterized protein conserved in bacteria 7 10 12 15 ----|||||||||---||------|--||--------------------------|---------- 16 [S] COG1656 Uncharacterized conserved protein 4 7 7 7 --|------|---||---||----------------|----------------------------- 10 [I] COG1657 Squalene cyclase 5 12 13 22 |||-|||||-------|---|----|----|||||||||-||------------------------ 24 [L] COG1658 Small primase-like proteins (Toprim domain) 3 3 3 4 ----------------||---------||------------------------------------- 4 [S] COG1659 Uncharacterized protein, linocin/CFP29 homolog 5 7 13 27 --------------------||----||||||||||||----|||||-||||||||---------- 27 [R] COG1660 Predicted P-loop-containing kinase 4 11 12 18 |-||||||||--|---------------------|--------||-|-|----------||-|--- 18 [R] COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif 5 5 6 9 --|--------|----|-|-----------------------||||-----|-------------- 46 [L] COG1662 Transposase and inactivated derivatives, IS1 family 4 7 14 27 ----------------|---|-||------------------|||||-|||||||||||||||||| 27 [M] COG1663 Tetraacyldisaccharide-1-P 4'-kinase 4 8 11 15 ----------------------||||----|-----|--------|--||--|--||||----|-- 21 [M] COG1664 Integral membrane protein CcmA involved in cell shape determination 2 6 6 6 |||-----||-|------------------------------------------------------ 6 [S] COG1665 Uncharacterized protein conserved in archaea 4 6 9 16 -------------------|-------||-------||----|||||-||||---|--|------- 16 [S] COG1666 Uncharacterized protein conserved in bacteria 1 4 4 4 ||------||-------------------------------------------------------- 5 [S] COG1667 Uncharacterized protein conserved in archaea 6 13 16 21 ||||--|||-|||----|---|--------||-|||||--------------|----------|-- 26 [CP] COG1668 ABC-type Na+ efflux pump, permease component 5 8 9 9 -||-----|--------||--|-------------------------------|-----|---|-- 24 [R] COG1669 Predicted nucleotidyltransferases 9 19 26 46 -|||||-|-----||--|-|||----||||||||||||--|-|||||-||-|-||||||||||||| 183 [J] COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins 3 5 8 19 ------------------------||----|---||||----|||||-||---------|||||-- 19 [S] COG1671 Uncharacterized protein conserved in bacteria 6 11 12 13 |||---||--||-----||||------------------------|------------|------- 91 [R] COG1672 Predicted ATPase (AAA+ superfamily) 2 5 6 7 ||----|||-||------------------------------------------------------ 11 [S] COG1673 Uncharacterized protein conserved in archaea 7 12 20 42 -------------------|-||||||||||||||||||---|||||-|||||||||||||||||| 84 [D] COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins 4 11 13 14 ||||--||||||||||-------------------------------------------------- 15 [K] COG1675 Transcription initiation factor IIE, alpha subunit 4 12 14 16 ||||||||||||||||-------------------------------------------------- 21 [J] COG1676 tRNA splicing endonuclease 5 9 12 25 ----------------||------||----|----|||----||||||||-----|||||||||-- 26 [NU] COG1677 Flagellar hook-basal body protein 4 6 13 27 ---------------------|||--||||------------|||||-||||||||---||||||| 27 [K] COG1678 Putative transcriptional regulator 3 9 10 13 |||---|||||-|------------------------------------|---------||-|--- 13 [S] COG1679 Uncharacterized conserved protein 7 12 18 35 --|---||--|-|-----||-|----||||||||||||----|||||--|--|--|---||||||| 111 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins 2 7 8 10 -||||||||--||----------------------------------------------------- 29 [N] COG1681 Archaeal flagellins 6 12 19 30 --|-----|-------|-||------|||||||-||||--------|-||-||||---|-|||||| 37 [GM] COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component 6 10 12 16 |-|-------------||--|---------|----|||--------|-||-----|---||-|--- 17 [S] COG1683 Uncharacterized conserved protein 5 9 12 25 ----------------||------||----|----|||----||||||||-----|||||||||-- 26 [NU] COG1684 Flagellar biosynthesis pathway, component FliR 2 9 11 12 ||||||-||||||----------------------------------------------------- 12 [EH] COG1685 Archaeal shikimate kinase 6 9 17 37 --------------------|-||||||||||||||||----|||||-||||||||---||||||| 83 [M] COG1686 D-alanyl-D-alanine carboxypeptidase 5 6 6 8 --|-----------------|-----|---------|-------------||----||-------- 9 [E] COG1687 Predicted branched-chain amino acid permeases (azaleucine resistance) 4 8 10 11 |||---|||-|||---||------------------------------------------------ 15 [L] COG1688 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 1 3 3 4 |-----|||--------------------------------------------------------- 4 [S] COG1689 Uncharacterized protein conserved in archaea 10 19 22 29 |||||||||||||--|||-|-|----|||-|------|----|||-|--|-----|---------- 38 [S] COG1690 Uncharacterized conserved protein 5 10 10 10 |||-----||-------|||------|---|----------------------------------- 10 [R] COG1691 NCAIR mutase (PurE)-related proteins 6 7 8 17 ----------------|---||---|--------||||||||-----------------|||||-- 18 [S] COG1692 Uncharacterized protein conserved in bacteria 1 5 5 5 |||-----||-------------------------------------------------------- 6 [S] COG1693 Uncharacterized protein conserved in archaea 12 18 27 43 --|---|||||||---|||||||||||||-||--||||----|||||-|||||------|||||-| 60 [R] COG1694 Predicted pyrophosphatase 9 17 22 36 |-|||||||-|||----|-|||----||||||||||||----|||||-|------|------||-- 102 [K] COG1695 Predicted transcriptional regulators 6 11 12 18 -------------||----||---|-----|||||||------------|---||-|-|-|----- 22 [M] COG1696 Predicted membrane protein involved in D-alanine export 4 11 13 14 ||||--||||||||||-------------------------------------------------- 14 [L] COG1697 DNA topoisomerase VI, subunit A 2 8 9 11 |||-||||||-||----------------------------------------------------- 11 [S] COG1698 Uncharacterized protein conserved in archaea 4 5 5 9 -----------------|------||----|-----||------------------|||------- 11 [S] COG1699 Uncharacterized protein conserved in bacteria 2 3 3 3 |-----|---------|------------------------------------------------- 3 [S] COG1700 Uncharacterized conserved protein 2 8 10 11 ||||--|||||||----------------------------------------------------- 11 [S] COG1701 Uncharacterized protein conserved in archaea 9 12 20 36 ---------||-|---||||-|----||||-|||||||----|||||-||-|||||---|||||-- 42 [T] COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase 6 11 12 19 ---||||||--||--------|----||||-------|----|||----------|-------|-- 21 [E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family 6 10 14 21 -||--------------|--|---|-------||-|--||---|||---|-|---|---|||||-- 22 [S] COG1704 Uncharacterized conserved protein 3 5 8 15 -----------------|-------------||-|||-----|||||-||-----|-----|---- 27 [NU] COG1705 Muramidase (flagellum-specific) 4 7 10 20 ----------------||-------|----------------||||||||-----|||||||||-- 21 [N] COG1706 Flagellar basal-body P-ring protein 1 4 4 4 ||------||-------------------------------------------------------- 4 [R] COG1707 ACT domain-containing protein 6 13 17 19 |||---|||||||---||------------|---|-----------|---|--------||----| 91 [R] COG1708 Predicted nucleotidyltransferases 2 8 10 12 -||||||||||||----------------------------------------------------- 12 [K] COG1709 Predicted transcriptional regulator 1 3 3 4 ||----||---------------------------------------------------------- 4 [S] COG1710 Uncharacterized protein conserved in archaea 1 6 6 8 |-|||||||--------------------------------------------------------- 8 [S] COG1711 Uncharacterized protein conserved in archaea 4 9 9 9 |||-----|||------|-------------------------------|-----|---------- 9 [R] COG1712 Predicted dinucleotide-utilizing enzyme 6 8 9 17 -----------------||-||--|-----||||||||||||------------------------ 20 [H] COG1713 Predicted HD superfamily hydrolase involved in NAD metabolism 5 11 16 27 |--------|--------||-------||||----|||----------|||--||||||||||||| 47 [S] COG1714 Predicted membrane protein/domain 5 7 7 9 |-||---------------|-|-----||-------------|---|------------------- 11 [V] COG1715 Restriction endonuclease 8 11 12 16 ----------||-||---||-|||--|||||------|--------------|------------- 58 [T] COG1716 FOG: FHA domain 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [J] COG1717 Ribosomal protein L32E 6 14 17 19 ||||||||||||||||-----|-----------------------|---|---------------- 20 [TD] COG1718 Serine/threonine protein kinase involved in cell cycle control 3 6 6 6 |||------|------|-|----------------------------------------------- 22 [R] COG1719 Predicted hydrocarbon binding protein (contains V4R domain) 4 12 18 25 ||||--|||||||----|------------------------|||||-||||-||-------||-- 28 [S] COG1720 Uncharacterized conserved protein 10 17 20 29 --|||||||-|-|---||||-|---|-|||-----|||----------||-----|---|||||-- 47 [R] COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) 7 11 19 39 -----------------|-|||----||||||||||||----|||||-|||||||||||||||||| 39 [L] COG1722 Exonuclease VII small subunit 5 6 6 8 -------------|||---|--||----------------------------------------|| 11 [S] COG1723 Uncharacterized conserved protein 4 7 8 9 --|--------------|||-------------------------|-----------|--|-||-- 13 [N] COG1724 Predicted periplasmic or secreted lipoprotein 6 8 9 15 ----|------|-----|||------|||-|-||||||---------------------------- 24 [K] COG1725 Predicted transcriptional regulators 2 3 6 9 ----------------------||---------------------|--||||-||----------- 9 [C] COG1726 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [J] COG1727 Ribosomal protein L18E 3 4 4 6 -----------------|------||----|-----||---------------------------- 6 [S] COG1728 Uncharacterized protein conserved in bacteria 2 4 10 19 ----------------|-------------------------|||||-||--||||---||||||| 19 [S] COG1729 Uncharacterized protein conserved in bacteria 4 12 14 16 |||||||||||||||-|------------------------------------------------- 17 [O] COG1730 Predicted prefoldin, molecular chaperone implicated in de novo protein folding 2 6 8 8 |||-----|||||----------------------------------------------------- 8 [H] COG1731 Archaeal riboflavin synthase 7 12 14 26 ---|----|----------|||-----||-|||||||-----|||-|--|-----|||-||||--- 32 [M] COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) 8 18 25 37 ||||||--|--||-----||||----|||-||--||||----|||||-||-||--|--|||-||-- 114 [K] COG1733 Predicted transcriptional regulators 5 9 16 30 ----------------|-----||||----|-----||----||||||||||||||--|||||||| 52 [T] COG1734 DnaK suppressor protein 5 7 7 12 -----------|---------|-----||------|-|-||-|---|------------|--|--- 13 [R] COG1735 Predicted metal-dependent hydrolase with the TIM-barrel fold 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [J] COG1736 Diphthamide synthase subunit DPH2 4 8 14 28 -----------------|--------|---||||||||-|--|||||-||||-|||---|||||-- 97 [K] COG1737 Transcriptional regulators 10 14 18 29 --||----|-|-|----|--||||-||-------|-|-----|||||-||||-||----||||--- 32 [S] COG1738 Uncharacterized conserved protein 9 16 21 36 --||---------||--|--||---||---||||||||||--|||-|-||||-|||||||||---- 38 [S] COG1739 Uncharacterized conserved protein 5 7 7 12 --|-----|-------|--|----------|-----------|||-|---------|||------- 21 [C] COG1740 Ni,Fe-hydrogenase I small subunit 6 10 14 24 --|-||----|-------||------|||-|-----------|||||-||-|---|---|||||-- 45 [R] COG1741 Pirin-related protein 5 7 9 17 --|---------------|--------||-----|-||----|||-|--|-----|---||-||-- 17 [S] COG1742 Uncharacterized conserved protein 4 6 6 7 ------||||--|----|------------------------------------------|----- 10 [L] COG1743 Adenine-specific DNA methylase containing a Zn-ribbon 8 14 16 28 ---|--|||-|-|----|-|-|--||----||||-|||||||-------|-----|---||||--- 54 [R] COG1744 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein 1 6 6 6 ||||----||-------------------------------------------------------- 9 [R] COG1745 Predicted metal-binding protein 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [J] COG1746 tRNA nucleotidyltransferase (CCA-adding enzyme) 2 2 2 4 ----------------------||||---------------------------------------- 4 [S] COG1747 Uncharacterized N-terminal domain of the transcription elongation factor GreA 7 13 16 22 ----|||-|-|-|||---||-|-----------|---|----------|--|----|||||||--- 26 [E] COG1748 Saccharopine dehydrogenase and related proteins 4 8 11 22 ----------------|-------||----|----|------||||||||-----|||||||||-- 27 [N] COG1749 Flagellar hook protein FlgE 2 5 7 8 -||---|||-|||----------------------------------------------------- 9 [R] COG1750 Archaeal serine proteases 2 5 5 5 |||-----|--------|------------------------------------------------ 5 [S] COG1751 Uncharacterized conserved protein 10 13 20 31 -------------||||||-|---|--|||-|----||----|||-|-||--||||---||||||| 68 [R] COG1752 Predicted esterase of the alpha-beta hydrolase superfamily 1 4 4 5 -||---|||--------------------------------------------------------- 8 [S] COG1753 Uncharacterized conserved protein 5 7 9 16 ------------------||-|---|||||----------------------|------||||||| 16 [R] COG1754 Uncharacterized C-terminal domain of topoisomerase IA 4 5 6 12 ---------------------|-----||---|||-||------------||-||----------- 12 [S] COG1755 Uncharacterized protein conserved in bacteria 4 9 11 13 -|--||||||||||||-------------------------------------------------- 13 [S] COG1756 Uncharacterized conserved protein 6 10 12 20 ---|--||----|-------|----|----|---|-||-------||-|-||-||-|||------- 43 [C] COG1757 Na+/H+ antiporter 12 25 35 58 ||||||||||||||||||||-|--||||||||||||||----|||||-|||||||||||||||||| 58 [K] COG1758 DNA-directed RNA polymerase, subunit K/omega 2 7 8 9 |||---||||||------------------------------------------------------ 15 [R] COG1759 ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) 5 9 15 34 --------------------||----||||||||||||----|||||-||||-|||||||||||-- 58 [E] COG1760 L-serine deaminase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 20 [K] COG1761 DNA-directed RNA polymerase, subunit L 6 10 16 34 --------------------|-|||||---||||||||-||||||||-||||-|||---|||||-- 127 [GT] COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) 5 15 19 31 |||||-|||||||---|-----------------||||----|||||-|-||---|--|||||--- 33 [H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein 5 8 13 23 ----||---------------|----|----|--|||---|||||-|-||--|--|---|||||-- 39 [O] COG1764 Predicted redox protein, regulator of disulfide bond formation 8 16 21 34 -||-||||-|-||---||---|----|||-|----|-|--|||||||-||---|||---||-||-- 44 [O] COG1765 Predicted redox protein, regulator of disulfide bond formation 5 9 12 25 ----------------||------||----|----|||----||||||||-----|||||||||-- 27 [NU] COG1766 Flagellar biosynthesis/type III secretory pathway lipoprotein 5 10 14 18 |||---||||-||-------|-----------|---------|||-|-|||--------------- 22 [H] COG1767 Triphosphoribosyl-dephospho-CoA synthetase 3 3 3 4 ---------------------|||------|----------------------------------- 4 [R] COG1768 Predicted phosphohydrolase 3 3 3 3 --------|-------||------------------------------------------------ 3 [L] COG1769 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) 4 5 10 21 -------------------|------||||---|--------|||||-||--|------||||||| 23 [E] COG1770 Protease II 1 3 3 4 ||----||---------------------------------------------------------- 4 [S] COG1771 Uncharacterized protein conserved in archaea 1 5 5 6 -||---||||-------------------------------------------------------- 6 [S] COG1772 Uncharacterized protein conserved in archaea 8 14 17 22 ||-----||--------||||---|--||-|-----------|||-|--|--||||-------|-- 33 [C] COG1773 Rubredoxin 8 10 11 14 -------------|||||--||--|-----||--||||---------------------------- 16 [S] COG1774 Uncharacterized homolog of PSP1 4 6 6 8 -|------||----------|---------|-----------|||--------------------- 10 [E] COG1775 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB 5 10 10 15 --||--|||--------|------|-----|----|||----------|-------|||------- 25 [NT] COG1776 Chemotaxis protein CheC, inhibitor of MCP methylation 1 6 6 8 |-|||||||--------------------------------------------------------- 10 [K] COG1777 Predicted transcriptional regulators 4 6 11 19 --|-------------|---|---------------------|||||-|||||||||||------- 19 [R] COG1778 Low specificity phosphatase (HAD superfamily) 3 10 12 14 |||-|||||||||||--------------------------------------------------- 14 [R] COG1779 C4-type Zn-finger protein 4 6 7 20 ---------------------|----||||-||||-|--||||||||------------|-|---- 22 [F] COG1780 Protein involved in ribonucleotide reduction 5 13 16 24 |||||||||||||----|------------|-----------|||||||----||----------- 24 [F] COG1781 Aspartate carbamoyltransferase, regulatory subunit 2 9 11 13 |||||||||||||----------------------------------------------------- 14 [R] COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain 3 3 4 5 -------------------------|------|--||-------------|--------------- 7 [R] COG1783 Phage terminase large subunit 1 7 7 8 ||||--||||-------------------------------------------------------- 8 [S] COG1784 Predicted membrane protein 8 13 15 20 --||---|-----||--|-|-|----|-------|-||----||||---|--|--|-----|---- 22 [P] COG1785 Alkaline phosphatase 3 9 10 13 |||---|||||-|------------------------------------|---------||-|--- 13 [S] COG1786 Uncharacterized conserved protein 5 5 5 6 -----------------||--|---------------|------------------||-------- 6 [V] COG1787 Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes 7 11 16 23 --------|--|--------||----|||-|-|---||----|------||----|||-|||||-| 35 [I] COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit 1 4 4 4 ||------||-------------------------------------------------------- 4 [S] COG1790 Uncharacterized protein conserved in archaea 5 6 7 7 -------------||-|--|----------------|------------|--|------------- 7 [S] COG1791 Uncharacterized conserved protein, contains double-stranded beta-helix domain 7 11 17 31 ----------------|--||-||||----||-|||||----|||||-|||||--||||----||| 33 [M] COG1792 Cell shape-determining protein 8 19 24 31 |||||||||||||||||----------||-------||----------|||--||---|||-||-- 66 [L] COG1793 ATP-dependent DNA ligase 3 7 10 17 ------|||----------------------|----|-----|||||----|---|--|||-||-- 22 [M] COG1794 Aspartate racemase 2 6 6 6 |||-----||-----------------------------------|-------------------- 7 [S] COG1795 Uncharacterized conserved protein 5 8 8 12 |-|-||-------||-|----|------------||||---------------------------- 12 [L] COG1796 DNA polymerase IV (family X) 8 18 20 26 ||||||--||||------||||-----||-|----|-|--------|--|-----|---||||--- 28 [H] COG1797 Cobyrinic acid a,c-diamide synthase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG1798 Diphthamide biosynthesis methyltransferase 4 6 7 15 ------------------|||-----||||||||||||---------------------------- 16 [S] COG1799 Uncharacterized protein conserved in bacteria 1 3 3 3 -|----|-|--------------------------------------------------------- 6 [R] COG1800 Predicted transglutaminase-like proteases 8 13 19 30 --|-|||||-|||---||-|-|------------||||----|||||-||-|---|---||-||-- 39 [S] COG1801 Uncharacterized conserved protein 8 11 16 30 ----|------|-----|--||----|||-|||-||||----|||||-||---|||---|||||-- 143 [K] COG1802 Transcriptional regulators 5 8 10 19 -----------------||------|----|----|||----|||||-|-||---|---|||---- 19 [G] COG1803 Methylglyoxal synthase 5 8 11 18 -----|--|-||---------|-----||-------------|||-|--|-----|---|||||-- 56 [C] COG1804 Predicted acyl-CoA transferases/carnitine dehydratase 3 6 9 12 ------------------||--||---------------------|--||||-||-------|--- 12 [C] COG1805 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB 3 5 11 23 ---------------------|------------||||----|||||-||--||||---||||||| 24 [S] COG1806 Uncharacterized protein conserved in bacteria 6 11 15 24 ------|||-------|-|||---------|-----|-----|||||--|--||||---|||||-- 44 [M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family 4 8 8 8 -|||----|---|-----||-------------|-------------------------------- 11 [S] COG1808 Predicted membrane protein 3 5 5 5 ||-------|----------------|---------|----------------------------- 5 [S] COG1809 Uncharacterized conserved protein 1 5 5 5 |||-----||-------------------------------------------------------- 12 [S] COG1810 Uncharacterized protein conserved in archaea 6 7 7 12 --------|--------|--||--------|----|||----|||-|------------------- 13 [R] COG1811 Uncharacterized membrane protein, possible Na+ channel or pump 4 11 13 15 |||||||||||||---|---------------|--------------------------------- 16 [E] COG1812 Archaeal S-adenosylmethionine synthetase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [K] COG1813 Predicted transcription factor, homolog of eukaryotic MBF1 9 16 19 21 ||--|||||||||||--|---||---|----|-----------------|------------||-- 30 [S] COG1814 Uncharacterized membrane protein 5 9 12 25 ----------------||------||----|----|||----||||||||-----|||||||||-- 26 [N] COG1815 Flagellar basal body protein 6 10 13 19 -------------||----|----|--|-|||----------|||-|-||-----|---||-||-- 24 [F] COG1816 Adenosine deaminase 2 5 5 6 |||---||--|------------------------------------------------------- 8 [S] COG1817 Uncharacterized protein conserved in archaea 3 7 9 10 ||----||||||||---------------------------------------------------- 17 [R] COG1818 Predicted RNA-binding protein, contains THUMP domain 7 12 14 19 |||------|---|----|--|-----||||-----|------||||-||------------|--- 38 [GC] COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase 9 12 18 33 -----------|-----|-|||---||||-||||||||-|--|||||-|||||------|||||-- 41 [G] COG1820 N-acetylglucosamine-6-phosphate deacetylase 1 5 5 5 |||-----||-------------------------------------------------------- 5 [R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) 1 3 3 4 ||----||---------------------------------------------------------- 8 [S] COG1822 Predicted archaeal membrane protein 3 4 6 12 -------------------------|--------|-|-----|||||-|-||------|------- 13 [R] COG1823 Predicted Na+/dicarboxylate symporter 2 7 7 8 |-||--||||--|----------------------------------------------------- 11 [P] COG1824 Permease, similar to cation transporters 9 13 20 41 ----------------||||-|||||||||----||||----|||||||||||||||||||||||| 41 [J] COG1825 Ribosomal protein L25 (general stress protein Ctc) 8 16 25 44 --||||--|||||---|-||-|----||||----||||----|||||-|||||||||||||||||| 86 [U] COG1826 Sec-independent protein secretion pathway components 4 6 7 10 |--------|-------|--|---------|-||-|||---------------------------- 14 [R] COG1827 Predicted small molecule binding protein (contains 3H domain) 9 18 21 31 ||||||||||||----||||-|----||||-|--||||--------------------|-||||-- 31 [F] COG1828 Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component 2 8 10 11 ||||--|||||||----------------------------------------------------- 11 [R] COG1829 Predicted archaeal kinase (sugar kinase superfamily) 6 13 15 23 ||||--||||-||---|--|--||------------------|||||----|-------||-|--- 33 [G] COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes 2 9 10 12 |||||||||||-|----------------------------------------------------- 12 [R] COG1831 Predicted metal-dependent hydrolase (urease superfamily) 7 12 15 27 ---|||||--|||---||---|---------|||-|||----|||||--------|--|||-|--- 27 [R] COG1832 Predicted CoA-binding protein 3 10 11 12 ||||-|||||||-----|------------------------------------------------ 12 [S] COG1833 Uncharacterized conserved protein 6 9 9 12 --|---------|-----||-------||-|-----||-----------|----------|-|--- 14 [E] COG1834 N-Dimethylarginine dimethylaminohydrolase 7 9 16 29 --|----------------|||----||||-||||||------||-|--||-||||---|||||-| 83 [I] COG1835 Predicted acyltransferases 4 11 11 13 |||||||||-|-------||-----------------|---------------------------- 13 [S] COG1836 Predicted membrane protein 10 12 13 23 ----------------||||||||||-|||||||-|||------------------|||------- 25 [R] COG1837 Predicted RNA-binding protein (contains KH domain) 6 14 18 25 |||---|||||-----||------------|------|----|||||-||--||||-----||--- 38 [C] COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain 5 8 10 13 |---|||||-|||----|---------||--------------------------|---------- 13 [S] COG1839 Uncharacterized conserved protein 7 12 19 29 --||------|-|-----|||-----|-----|||--|-----||||-||||||||--|||||--- 74 [P] COG1840 ABC-type Fe3+ transport system, periplasmic component 12 23 33 54 ||||||||||||||||||--||--||||||||||||||----||||||||||||||----|||||| 60 [J] COG1841 Ribosomal protein L30/L7E 7 10 13 21 --|-------------|-||-|----|||-|----|||----|||||-||------------||-- 30 [KT] COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription 5 9 12 25 ----------------||------||----|----|||----||||||||-----|||||||||-- 26 [N] COG1843 Flagellar hook capping protein 1 5 5 6 |||---||-|-------------------------------------------------------- 6 [S] COG1844 Uncharacterized protein conserved in archaea 9 12 18 33 ---|------||||--|-||-|----||||----||||----||||||-|--|--|---||||||| 56 [C] COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3 9 19 27 45 |||||||||||||----|-|||----||||||||||||----|||||-||--||||---|||||-- 336 [K] COG1846 Transcriptional regulators 7 9 10 17 -----------------|||||--||-|||||||-|||---------------------------- 17 [R] COG1847 Predicted RNA-binding protein 5 7 9 11 -|----|||-|||--------|-----||-------------------------------|----- 87 [R] COG1848 Predicted nucleic acid-binding protein, contains PIN domain 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [S] COG1849 Uncharacterized protein conserved in archaea 4 8 8 10 -||---|||---------||----------------|-----------------------|-|--- 12 [G] COG1850 Ribulose 1,5-bisphosphate carboxylase, large subunit 2 3 3 4 -|----||--------|------------------------------------------------- 4 [S] COG1851 Uncharacterized conserved protein 2 6 6 6 |||----||-----------|--------------------------------------------- 7 [S] COG1852 Uncharacterized conserved protein 11 19 27 44 |-|-|-|||-|||-|-||||||----||||||-|||||----|||||--|-|-|||---||||||| 100 [R] COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family 4 7 10 23 ---------------------|---|----||||||||----|||||-|-||-||-|||------- 23 [T] COG1854 LuxS protein involved in autoinducer AI2 synthesis 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [R] COG1855 ATPase (PilT family) 4 4 4 5 ------||---|----||------------------------------------------------ 5 [S] COG1856 Uncharacterized homolog of biotin synthetase 4 8 10 11 |||---|||-|||---|---|--------------------------------------------- 17 [L] COG1857 Uncharacterized protein predicted to be involved in DNA repair 4 7 10 17 --|-------------|----|--------------------|||||-||-|---|||||--|--- 24 [P] COG1858 Cytochrome c peroxidase 6 12 14 18 --|-|||||||-|||-----||--------------------|||----|---------|------ 19 [J] COG1859 RNA:NAD 2'-phosphotransferase 2 8 8 9 |||||||-|-|------------------------------------------------------- 9 [S] COG1860 Uncharacterized protein conserved in archaea 5 6 6 6 -|------------------|---|-----|-----|--------------------------|-- 7 [M] COG1861 Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog 8 12 20 42 ----------------||--|-||-|||||||||||||----|||||||||||||||||||||||| 43 [U] COG1862 Preprotein translocase subunit YajC 6 11 13 20 ||||--||---------|---|----|-------||||----------||---------|||--|| 30 [P] COG1863 Multisubunit Na+/H+ antiporter, MnhE subunit 6 10 11 13 --|----------||----||----|--------------------|--|-----||||----|-- 15 [F] COG1864 DNA/RNA endonuclease G, NUC1 3 9 11 14 -||||||||||||-----------------------||---------------------------- 14 [S] COG1865 Uncharacterized conserved protein 6 8 11 21 ------------||------||------------|-||----|||||-||||------|||||--- 21 [C] COG1866 Phosphoenolpyruvate carboxykinase (ATP) 5 13 15 17 |||||||||||||||||------------------------------------------------- 18 [J] COG1867 N2,N2-dimethylguanosine tRNA methyltransferase 5 9 11 24 ----------------||------||----|----|||----||||||||-----||||||||--- 24 [N] COG1868 Flagellar motor switch protein 4 5 8 15 -----------------|--------|----|--|-||-|--|||||-|-||-------------- 16 [G] COG1869 ABC-type ribose transport system, auxiliary component 5 11 13 16 --||--|||--------|-------|----|-----||----------||-----|---||--|-- 17 [NT] COG1871 Chemotaxis protein; stimulates methylation of MCP proteins 6 12 16 23 |||----|||--|------|--||----|-------------|||||-|--|-------|--|||| 23 [S] COG1872 Uncharacterized conserved protein 2 10 10 13 ||||||||||--------------------|-----||---------------------------- 25 [S] COG1873 Uncharacterized conserved protein 4 6 9 11 ------||---------|------------|--|--||-------|------|-------|--|-- 15 [G] COG1874 Beta-galactosidase 5 6 8 13 -----------------|----||--||||------||----------||--|--|---------- 14 [T] COG1875 Predicted ATPase related to phosphate starvation-inducible protein PhoH 4 6 10 16 ------------------||----||----||||-|||-------|--|-|||------------- 18 [M] COG1876 D-alanyl-D-alanine carboxypeptidase 6 10 10 17 |---||----|--|||----------||||------------|||-|--------|------|--- 24 [G] COG1877 Trehalose-6-phosphatase 7 16 18 25 ||||||-||-||-----|||------|||-----|--|-----------|||---|---||-|--- 30 [R] COG1878 Predicted metal-dependent hydrolase 7 10 15 25 --|--------------|--|---|-|--|||----||----|||||-||||---|---|||||-- 183 [G] COG1879 ABC-type sugar transport system, periplasmic component 1 5 5 5 |||-----||-------------------------------------------------------- 7 [C] COG1880 CO dehydrogenase/acetyl-CoA synthase epsilon subunit 8 18 23 37 |-|||||||--|-|--|-----||--|||||---|-|-|---|||-|-|--|||||||-||-|--| 44 [R] COG1881 Phospholipid-binding protein 4 7 10 18 |-------|-----------|---------||||||------|||||-|-||---|---------- 34 [C] COG1882 Pyruvate-formate lyase 6 7 9 10 ------|||--------|--|---|-------|-------------|-|--|-------------- 14 [C] COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit 6 11 13 23 ---||||||--||--------|----||||-------|----|||----------|---|||||-- 36 [I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit 1 6 6 7 -|||--||||-------------------------------------------------------- 8 [S] COG1885 Uncharacterized protein conserved in archaea 6 10 13 27 ----------------||----||||----|----|||----||||||||-----|||||||||-- 45 [NU] COG1886 Flagellar motor switch/type III secretory pathway protein 3 4 6 8 |-----|------------------------|--|||------------|--|------------- 22 [M] COG1887 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC 2 7 9 11 ||--|||||||||----------------------------------------------------- 11 [S] COG1888 Uncharacterized protein conserved in archaea 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG1889 Fibrillarin-like rRNA methylase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG1890 Ribosomal protein S3AE 1 5 5 5 |||-----||-------------------------------------------------------- 5 [S] COG1891 Uncharacterized protein conserved in archaea 2 7 8 9 |-||--||||||------------------------------------------------------ 9 [S] COG1892 Uncharacterized protein conserved in archaea 8 14 19 30 ---|--|||-|-|||-|--|------|||-|||-||||----|||||-||-----|------||-- 44 [H] COG1893 Ketopantoate reductase 8 11 16 27 |-------------|-||||-|-----||-------------||||||-|--||||---||||||| 33 [C] COG1894 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit 2 5 5 5 -||---|-|--------|------------------------------------------------ 6 [S] COG1895 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN 6 12 18 29 ---|--|||||||||------|------------||------|||||-||-|----||||||||-- 31 [R] COG1896 Predicted hydrolases of HD superfamily 3 6 8 16 -----------------|------------||-|--||----|||||-|---------||||---- 16 [E] COG1897 Homoserine trans-succinylase 8 17 24 37 |-|--||||--||-----||||----|||||||||-||----|---|--|-|||||--||||||-- 47 [M] COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes 6 14 16 18 ||||||||||||||||---|-------------------------------------------|-- 20 [O] COG1899 Deoxyhypusine synthase 2 7 7 7 |||-----||--------||---------------------------------------------- 11 [S] COG1900 Uncharacterized conserved protein 3 8 9 10 -|||--|||||-|-----------------------------------|----------------- 10 [S] COG1901 Uncharacterized conserved protein 10 18 23 37 --||||--|--|-||--|-|||----|||-|||-||||-|--|||||-||--|--|---|||||-- 95 [C] COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family 6 15 17 19 |||-||--||||------|||---------|----|----------|--|-----|---|-|---- 19 [H] COG1903 Cobalamin biosynthesis protein CbiD 4 6 8 15 -----------------|--------|---||----||----|||||-------------||||-- 16 [G] COG1904 Glucuronate isomerase 8 11 16 27 |-------------|-||||-|-----||-------------||||||-|--||||---||||||| 34 [C] COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit 3 4 4 5 ------|||-|------|------------------------------------------------ 5 [S] COG1906 Uncharacterized conserved protein 2 7 8 9 |||---||||-||----------------------------------------------------- 13 [R] COG1907 Predicted archaeal sugar kinases 1 5 5 5 |||-----||-------------------------------------------------------- 9 [C] COG1908 Coenzyme F420-reducing hydrogenase, delta subunit 2 8 10 12 |||-|||||||||----------------------------------------------------- 12 [S] COG1909 Uncharacterized protein conserved in archaea 4 9 9 10 -|||||--|-|-------------------|-----|------------------|---------- 12 [P] COG1910 Periplasmic molybdate-binding protein/domain 4 10 12 13 |||---||||||||||-------------------------------------------------- 14 [J] COG1911 Ribosomal protein L30E 7 13 16 20 -|||--|||||||---||-|-------------|||-------||-----------||-------- 20 [S] COG1912 Uncharacterized conserved protein 3 7 9 10 -|-|--|||||||---|------------------------------------------------- 12 [R] COG1913 Predicted Zn-dependent proteases 9 13 18 35 ----||-----|-||----|||----||||||-|||||----|||||--|||||||---||||--- 50 [P] COG1914 Mn2+ and Fe2+ transporters of the NRAMP family 2 6 6 6 ||------||--------||---------------------------------------------- 6 [S] COG1915 Uncharacterized conserved protein 3 9 9 11 ||||--||||--------------||--------------------------|------------- 11 [S] COG1916 Uncharacterized homolog of PrgY (pheromone shutdown protein) 9 19 22 34 ||||||||--||----|||||-----||--|||--|||-------||--|-----||||||||--- 58 [S] COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain 6 15 19 25 |||----|||-------||--|--------||--||------|||||-||--|--|-||----|-- 29 [P] COG1918 Fe2+ transport system protein A 2 7 7 9 ||||----||-----------------|||------------------------------------ 9 [S] COG1920 Uncharacterized conserved protein 3 8 10 19 ||--|----|------|-------------------------|||||--|||----|||||-|--- 21 [E] COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase] 6 9 12 20 -----------------|||-|--|-----|---|||-----|||||-|---|------|-|||-- 23 [M] COG1922 Teichoic acid biosynthesis proteins 5 8 14 25 -|--------------||------------|---||||----|||||-||||||||----||||-- 25 [R] COG1923 Uncharacterized host factor I protein 6 11 12 14 |||-----||------||--|---------||---|------|||--------------------- 19 [I] COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) 7 11 18 38 --------------------|||||||---||||||||||||||||||||||||||---|||||-- 76 [G] COG1925 Phosphotransferase system, HPr-related proteins 5 8 8 12 --|-||----------|--|-------||--------------------------|||--|-|--- 16 [R] COG1926 Predicted phosphoribosyltransferases 1 5 5 5 |||-----||-------------------------------------------------------- 5 [C] COG1927 Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase 4 6 6 9 -------------|||--||------||||------------------------------------ 17 [O] COG1928 Dolichyl-phosphate-mannose--protein O-mannosyl transferase 4 6 10 23 ------------------|-------|||-||||||||----|||||-||||-||----------- 31 [G] COG1929 Glycerate kinase 4 8 8 8 ||||----|----------|---------------|----------|------------------- 8 [P] COG1930 ABC-type cobalt transport system, periplasmic component 2 8 10 11 ||||--|||||||----------------------------------------------------- 11 [S] COG1931 Uncharacterized protein conserved in archaea 6 10 17 32 --|----------||----|------||||-|---|||----||||||||||||||--||||||-- 32 [HE] COG1932 Phosphoserine aminotransferase 1 8 8 10 ||||||||||-------------------------------------------------------- 12 [L] COG1933 Archaeal DNA polymerase II, large subunit 3 7 13 24 ----------------|-||----------------------|||||-||||||||||||||||-- 24 [S] COG1934 Uncharacterized protein conserved in bacteria 1 5 5 6 -||---||||-------------------------------------------------------- 6 [S] COG1935 Uncharacterized conserved protein 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases) 5 10 12 22 ------------------||-|----||||||--||||----|||-|--|-----|--|||----- 38 [S] COG1937 Uncharacterized protein conserved in bacteria 2 9 11 13 |||||||||||||----------------------------------------------------- 17 [R] COG1938 Archaeal enzymes of ATP-grasp superfamily 4 6 7 12 -----------------||||---------||||||||---------------------------- 12 [S] COG1939 Uncharacterized protein conserved in bacteria 11 17 22 39 ---|||--|-|-|---||||||---|||||||||||||-|--|||||-|-||-------|||||-- 155 [KG] COG1940 Transcriptional regulator/sugar kinase 2 8 8 9 |||---||||--------||---------------------------------------------- 16 [C] COG1941 Coenzyme F420-reducing hydrogenase, gamma subunit 5 9 13 26 |-------|----------|------|----|||||||----||||------|||||||||-||-- 33 [R] COG1942 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog 9 15 21 28 --||||-----|-----|-|||------|-|--|---|----|||||-|||--|||||----||-- 153 [L] COG1943 Transposase and inactivated derivatives 3 8 10 18 ||||-----|-----------------||-------------|||||--|||-------||-|--- 20 [S] COG1944 Uncharacterized conserved protein 2 9 9 12 ||||||||||------------||------------------------------------------ 15 [S] COG1945 Uncharacterized conserved protein 4 5 10 21 -------------|-|----------||||------------|||||-|||||------|||||-- 25 [I] COG1946 Acyl-CoA thioesterase 10 16 22 40 ----------------|||||||-|-|||||---|||||---||||||||||||||||||||||-- 40 [I] COG1947 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase 4 11 13 14 ||||--||||||||||-------------------------------------------------- 18 [L] COG1948 ERCC4-type nuclease 3 5 10 20 -------------||-----------||||------------||||||||||||||---------- 20 [A] COG1949 Oligoribonuclease (3'->5' exoribonuclease) 5 6 6 11 ------------------||-|----||||-----|||-----------------|---------- 13 [S] COG1950 Predicted membrane protein 6 14 18 25 |||---|||||-----||------------|------|----|||||-||--||||-----||--- 37 [C] COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain 2 4 11 22 -|----------------------------------------||||||||||||||---||||||| 22 [U] COG1952 Preprotein translocase subunit SecB 4 7 10 16 -----------||||---------------------|-----|||||--|-----|----||||-- 25 [FH] COG1953 Cytosine/uracil/thiamine/allantoin permeases 4 5 5 10 -----------------|--|---------|---||||----|||--------------------- 12 [K] COG1954 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) 2 7 8 10 -||||||||--||----------------------------------------------------- 11 [NU] COG1955 Archaeal flagella assembly protein J 5 9 15 26 ---|||-------|---|------------||||||||----|||||-||-||||-------||-- 26 [T] COG1956 GAF domain-containing protein 7 11 14 23 -----------|-||----|-|----|||-----|--|----|||-|--|-|---|--||||||-- 47 [F] COG1957 Inosine-uridine nucleoside N-ribohydrolase 4 11 13 15 |-||||||||||||||-------------------------------------------------- 66 [K] COG1958 Small nuclear ribonucleoprotein (snRNP) homolog 8 13 21 36 ----------------||||||-----||-||-|||||----|||||-||||||||--|||||||| 86 [K] COG1959 Predicted transcriptional regulator 9 14 20 34 ---|||--|-||||-----|||----|||||---|-||----|||||-||---|||---|||||-- 309 [I] COG1960 Acyl-CoA dehydrogenases 7 12 17 30 -----||---|-------||-|----|||-|-||||||----|||||-||--|--|---|||||-- 84 [L] COG1961 Site-specific recombinases, DNA invertase Pin homologs 1 5 5 5 |||-----||-------------------------------------------------------- 6 [H] COG1962 Tetrahydromethanopterin S-methyltransferase, subunit H 5 6 7 10 -----------------|||-|--||-----|---|||---------------------------- 10 [S] COG1963 Uncharacterized protein conserved in bacteria 3 9 11 14 |||-|||||||||--------------||------------------------------------- 16 [R] COG1964 Predicted Fe-S oxidoreductases 3 6 10 18 -------------|||--------------------------||||||||||-|||--------|| 18 [P] COG1965 Protein implicated in iron transport, frataxin homolog 7 11 17 28 --|----|--|-|---|---|-----|||-||----||----|||||-||||-||||||------- 34 [T] COG1966 Carbon starvation protein, predicted membrane protein 1 6 6 7 ||||--|||--------------------------------------------------------- 10 [S] COG1967 Predicted membrane protein 11 17 24 40 |--------|||----||||||---||||||||||-||----||||||||--||||--||||||-- 45 [V] COG1968 Uncharacterized bacitracin resistance protein 2 3 3 8 ----------------|-------------------------|||-|---------|||------- 9 [C] COG1969 Ni,Fe-hydrogenase I cytochrome b subunit 7 9 15 30 --|---------------|-||----||||-||||||-----|||||-|||||--|---|||||-- 33 [M] COG1970 Large-conductance mechanosensitive channel 5 9 11 17 |-|-----------------|-----|---|-----||----|||||--|--|||---|------- 21 [S] COG1971 Predicted membrane protein 3 5 8 16 -------------------|------------|-|-||----|||||-|-||----||-----|-- 29 [F] COG1972 Nucleoside permease 2 6 6 6 |||-----||-|------------------------------------------------------ 6 [O] COG1973 Hydrogenase maturation factor 6 10 16 30 -----------------|||-|----||||||--||||----|||||-|||||--|---|||||-- 50 [KT] COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases) 5 7 11 18 ----------|||--------|-----||-------||----|||----|-----|---|||||-- 34 [O] COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG1976 Translation initiation factor 6 (eIF-6) 8 16 21 36 --||||-||-||----|-||-|-----||-----||||----|||||-||||---|||||||||-- 56 [H] COG1977 Molybdopterin converting factor, small subunit 3 4 4 4 ----------------||------------|-----|----------------------------- 4 [S] COG1978 Uncharacterized protein conserved in bacteria 5 6 8 14 -----------------|-||---------|----|||----|||||-|--|-------------- 17 [C] COG1979 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family 3 8 10 12 ||--|||||||||---|------------------------------------------------- 12 [G] COG1980 Archaeal fructose 1,6-bisphosphatase 2 6 10 17 ------------------||-----------------------------|--|||||||||||||| 17 [S] COG1981 Predicted membrane protein 5 9 13 23 ------------------|||------||||--|||||----|||||-||||---|----|----- 46 [E] COG1982 Arginine/lysine/ornithine decarboxylases 5 7 9 18 --|---||---------|--------|---||||-|||----|||||-|----------------- 24 [KT] COG1983 Putative stress-responsive transcriptional regulator 7 10 15 26 ------||-----|------||----||||----|-||----|||||-|||--|||--||---|-- 31 [E] COG1984 Allophanate hydrolase subunit 2 12 23 32 51 ||||----|||||||-||||||||--||||||-||-||----||||||||||||||||||||||-- 61 [H] COG1985 Pyrimidine reductase, riboflavin biosynthesis 4 8 11 16 ||--||--|||||------------------------|----|||||-|----------------- 16 [S] COG1986 Uncharacterized conserved protein 5 9 12 25 ----------------||------||----|----|||----||||||||-----|||||||||-- 26 [NU] COG1987 Flagellar biosynthesis pathway, component FliQ 4 10 12 20 |||---||||--|-----------------|---||||----|||||--|-|-------------- 35 [R] COG1988 Predicted membrane-bound metal-dependent hydrolases 8 19 26 40 ||||--||||------||||-|----|||-||||||||----|||||-||||||||--|---||-- 50 [NOU] COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases 5 13 15 17 ||||||||||||||||----------|--------------------------------------- 17 [S] COG1990 Uncharacterized conserved protein 1 4 4 5 ||----||-|-------------------------------------------------------- 9 [S] COG1991 Uncharacterized conserved protein 3 8 10 11 ||||--||-||||----|------------------------------------------------ 17 [S] COG1992 Uncharacterized conserved protein 5 8 9 11 -||---||-|------||---------||--------------------------------|-|-- 13 [S] COG1993 Uncharacterized conserved protein 9 21 25 32 ||||||-||||||---||||-|-----||-|----|||----------|----|||||--|-||-- 43 [R] COG1994 Zn-dependent proteases 5 9 15 25 ----------------|-|||----------------|----|||||-||-|||||||||||||-- 30 [H] COG1995 Pyridoxal phosphate biosynthesis protein 4 12 14 16 |||||||||||||||---------------|----------------------------------- 16 [K] COG1996 DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) 4 12 14 16 ||||||||||||||||-------------------------------------------------- 19 [J] COG1997 Ribosomal protein L37AE/L43A 3 11 13 15 |||||||||||||||--------------------------------------------------- 16 [J] COG1998 Ribosomal protein S27AE 7 11 17 23 ---|------|-|||-|----|--------------||----------||--||||--|||||||| 37 [R] COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems 2 4 4 4 ||-------|-------|------------------------------------------------ 4 [R] COG2000 Predicted Fe-S protein 5 9 15 31 ---------------------|--|-|||||---|||||||||||||--|||||||----|--||| 31 [S] COG2001 Uncharacterized protein conserved in bacteria 6 11 13 21 ---|--|||-|||-----||-------||-|----|||----|||--------------||-|--- 47 [K] COG2002 Regulators of stationary/sporulation gene expression 7 11 18 32 --|-------------|||||---------||||||||----|||||-||||||||---||||--| 45 [L] COG2003 DNA repair proteins 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG2004 Ribosomal protein S24E 3 9 13 20 |-|-----||||------------------------------|||||--|||---|--|||-||-- 22 [R] COG2005 N-terminal domain of molybdenum-binding protein 3 6 6 6 |-|-----|--------|||---------------------------------------------- 9 [S] COG2006 Uncharacterized conserved protein 4 12 14 16 ||||||||||||||||-------------------------------------------------- 21 [J] COG2007 Ribosomal protein S8E 8 12 15 24 ---|---------||--|-|||--------|---||-|----|||||-||-----|---|||||-- 27 [E] COG2008 Threonine aldolase 8 14 21 38 ---|||--|-|-|||------|||---|||----|-||----|||||-||--|||||||||||||| 40 [C] COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit 6 11 14 24 --|-----|---------||-|----||||------||----------||---|||||||||||-- 78 [C] COG2010 Cytochrome c, mono- and diheme variants 7 11 18 34 --------------------||-||-|---||||||||----|||||-||||||||||||||||-- 39 [P] COG2011 ABC-type metal ion transport system, permease component 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [K] COG2012 DNA-directed RNA polymerase, subunit H, RpoH/RPB5 7 15 17 19 |-||||-|||-||----||--|--------|||----------------|------------||-- 29 [S] COG2013 Uncharacterized conserved protein 1 4 4 5 |||---||---------------------------------------------------------- 5 [S] COG2014 Uncharacterized conserved protein 3 4 6 9 -------------|-------------||-------------|||---||-------------|-- 9 [Q] COG2015 Alkyl sulfatase and related hydrolases 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [J] COG2016 Predicted RNA-binding protein (contains PUA domain) 9 14 19 32 ----||-----|-||--|||||--------||-|||||----|||-|-|-||-|||---|||||-- 58 [G] COG2017 Galactose mutarotase and related enzymes 5 8 8 10 ||------||------|----|-----||------------------------||----------- 19 [R] COG2018 Uncharacterized distant relative of homeotic protein bithoraxoid 3 7 9 11 ||--||||-||||------------------------------------------------|---- 12 [F] COG2019 Archaeal adenylate kinase 8 14 15 20 --|---|||---||||--||-------||-|-----------------|-||---|----|||--- 39 [O] COG2020 Putative protein-S-isoprenylcysteine methyltransferase 6 11 15 21 |-||---------||------|----||||----||-------------|||||||------||-- 25 [E] COG2021 Homoserine acetyltransferase 7 12 17 29 ----------------|-||||----|||||-----||----|||||-||--||||--||||||-- 29 [H] COG2022 Uncharacterized enzyme of thiazole biosynthesis 4 12 13 15 ||||||||||-|||||-------------------------------------------------- 15 [J] COG2023 RNase P subunit RPR2 1 5 5 5 |||-----||-------------------------------------------------------- 5 [J] COG2024 Phenylalanyl-tRNA synthetase alpha subunit (archaeal type) 9 15 21 33 ---|||--|-|||||--|--||----|||||-----||----|||-|--|--||||---|||||-- 57 [C] COG2025 Electron transfer flavoprotein, alpha subunit 7 13 14 18 -||---|-|---|-----|||------||----|--------|--||-|------|---||----- 39 [JD] COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system 6 8 13 22 --|---------------||-|----||||------|-----|||||-||||||||---------- 25 [M] COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) 1 3 3 4 -|----|||--------------------------------------------------------- 4 [S] COG2028 Uncharacterized conserved protein 1 5 5 6 |||---||-|-------------------------------------------------------- 6 [S] COG2029 Uncharacterized conserved protein 8 12 15 24 ---|----|--|-||-----||----||||----|-|-----|--||-||-----|---|||||-- 79 [I] COG2030 Acyl dehydratase 6 7 10 11 --------|---|-------|-----|-----|----|----|------||-----||-------- 12 [I] COG2031 Short chain fatty acids transporter 7 11 15 23 --|----------||-|----|-----||||-----|-----|||||-|--|-|||----||-|-- 31 [P] COG2032 Cu/Zn superoxide dismutase 4 8 8 9 |||---|||--------|------|-----|----------------------------------- 10 [C] COG2033 Desulfoferrodoxin 2 8 9 11 |||-||||||-||----------------------------------------------------- 12 [S] COG2034 Predicted membrane protein 7 8 9 12 |--|-------------|--|---|||-----|||--|----------|----------------- 12 [S] COG2035 Predicted membrane protein 3 10 10 11 ||||--||||---|||-------------------------------------------------- 40 [B] COG2036 Histones H3 and H4 1 5 5 5 |||-----||-------------------------------------------------------- 8 [C] COG2037 Formylmethanofuran:tetrahydromethanopterin formyltransferase 8 19 24 35 |||||||||||||-----||||----|||||------|----|||-|-||-----|---|||||-- 36 [H] COG2038 NaMN:DMB phosphoribosyltransferase 7 8 9 14 ------||---|--------||-----||---|||-||-------|---------|---------- 17 [O] COG2039 Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) 5 8 8 11 -------------||---|--------||||-----|-----|----------------|--|--- 13 [E] COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) 8 14 19 29 --||||--|-|||---|--|-|----|||-------|-----|||||--|-|---|--||||||-- 43 [R] COG2041 Sulfite oxidase and related enzymes 4 10 10 11 ||||||---|-|-|||-------------------------------------------------- 11 [S] COG2042 Uncharacterized conserved protein 1 5 5 5 |||-----||-------------------------------------------------------- 14 [S] COG2043 Uncharacterized protein conserved in archaea 4 7 8 8 ||------||||----|--------------------------------|---------------- 13 [R] COG2044 Predicted peroxiredoxins 6 11 11 12 ||--||---|-------|||-|--------|-----|------------------|---------- 12 [HR] COG2045 Phosphosulfolactate phosphohydrolase and related enzymes 8 11 13 14 -------||-|||||-|-||-|--------------||--------------------|------- 16 [P] COG2046 ATP sulfurylase (sulfate adenylyltransferase) 1 8 8 10 ||||||||||-------------------------------------------------------- 10 [R] COG2047 Uncharacterized protein (ATP-grasp superfamily) 5 10 10 10 |||-----||-|----|-||--------------------------------------|------- 17 [C] COG2048 Heterodisulfide reductase, subunit B 7 10 15 25 ------||-----|------||----||||----|-||----|||-|-|||--|||--||---|-- 30 [E] COG2049 Allophanate hydrolase subunit 1 8 15 21 40 --|||||||-||--|-|----|----|||--|||||||----|||||-||||---|||||||||-- 88 [Q] COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [J] COG2051 Ribosomal protein S27E 3 5 5 6 -----------------|||----------|-----||---------------------------- 6 [S] COG2052 Uncharacterized protein conserved in bacteria 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG2053 Ribosomal protein S28E/S33 1 5 5 5 |||-----||-------------------------------------------------------- 5 [R] COG2054 Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases 4 9 11 19 ||----||-|----------------|---|-----|-----|||-|--|||-------||||--- 32 [C] COG2055 Malate/L-lactate dehydrogenases 3 5 7 13 --------------------|-------------|-||----------||||-||-|||------- 15 [R] COG2056 Predicted permease 6 10 15 22 -----------|--------||----|||-|-|---||----|------||----|||-|||||-| 32 [I] COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit 4 12 14 16 ||||||||||||||||-------------------------------------------------- 24 [J] COG2058 Ribosomal protein L12E/L44/L45/RPP1/RPP2 9 13 15 18 -|---------------|||||---||---------||-|--------||-----|---||-||-- 27 [P] COG2059 Chromate transport protein ChrA 6 11 13 22 ---|||------------||-|-----||-|---||------|||||--|-----|---||-||-- 26 [P] COG2060 K+-transporting ATPase, A chain 1 5 5 5 |||-----||-------------------------------------------------------- 5 [E] COG2061 ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase 6 10 17 28 --------|-|||---|-||------||||------------|||||-|||||--|--||||||-- 31 [T] COG2062 Phosphohistidine phosphatase SixA 3 6 9 19 ----------------||------------------------||||||||-----|||||||||-- 20 [N] COG2063 Flagellar basal body L-ring protein 5 14 19 24 |||||||||||||-------------||--|--------------|---|-|---|---||-||-- 44 [NU] COG2064 Flp pilus assembly protein TadC 6 9 11 19 ------------------||||----|||-||||||||-----------|||---|---------- 19 [F] COG2065 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase 5 8 11 19 ------------------|||-----|---------||----|||||-||-----|---|||||-- 27 [E] COG2066 Glutaminase 3 6 11 21 ----------------|---|---------------------|||||-|||||||-||-|||||-- 26 [I] COG2067 Long-chain fatty acid transport protein 6 9 12 18 |--------||||--------|-----||-------||----|||----------|---||-||-- 20 [R] COG2068 Uncharacterized MobA-related protein 1 5 5 5 |||-----||-------------------------------------------------------- 6 [C] COG2069 CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein) 10 14 18 30 --------|----|--||-|||----|||-||||||||-----------|--||||||||||-|-- 53 [R] COG2070 Dioxygenases related to 2-nitropropane dioxygenase 5 8 12 22 --------------|-----|------|||||||-|------|||----|--------|||||||| 26 [R] COG2071 Predicted glutamine amidotransferases 6 9 10 16 -------------||---|--|----||||------||-----------|-----|---||-||-- 50 [P] COG2072 Predicted flavoprotein involved in K+ transport 6 15 17 21 ||-|||--||||------|||---------|----|----------|--|-----|---||||--- 25 [H] COG2073 Cobalamin biosynthesis protein CbiG 2 6 6 8 ||--||||-|-----------|-------------------------------------------- 10 [G] COG2074 2-phosphoglycerate kinase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 21 [J] COG2075 Ribosomal protein L24E 6 11 15 27 --||---------------|-|-----|||||---|||----|||||-||---||---||||||-- 65 [P] COG2076 Membrane transporters of cations and cationic drugs 4 8 12 25 ----------------|---------|||-||-|||||-|--|||||-||||---||||------- 26 [O] COG2077 Peroxiredoxin 6 14 16 18 |||||||||||||||-||------------|----------------------------------- 19 [S] COG2078 Uncharacterized conserved protein 6 9 12 21 |---||----||||------------|||-------||----|||-|--|-----|---||-|--- 29 [R] COG2079 Uncharacterized protein involved in propionate catabolism 6 8 12 19 ----------|||--------|--||-||-------||----|||----|-----|---||-||-- 49 [C] COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs 3 7 12 24 ------------------||----------||||||||----|||||-||||---|---|||-|-- 31 [R] COG2081 Predicted flavoproteins 7 17 19 24 ||||||--||||------|||------||-|----|----------|--|-----|---||||--- 28 [H] COG2082 Precorrin isomerase 1 5 5 6 ||----||||-------------------------------------------------------- 6 [S] COG2083 Uncharacterized protein conserved in archaea 8 15 23 36 |-|-||----|||---|-||-|-----||-||---|||----|||||-||||-|||-|-|||||-- 79 [I] COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases 5 12 12 14 ||||----||---------|------|----|--------------------|--|---||-|--- 18 [R] COG2085 Predicted dinucleotide-binding enzymes 9 15 21 33 ---|||--|-|||||--|--||----|||||-----||----|||-|--|--||||---|||||-- 54 [C] COG2086 Electron transfer flavoprotein, beta subunit 6 10 12 21 ------------------||||----|||-|----|-|----|||-|-||-----|---||||--- 22 [H] COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase 4 5 5 8 --------|-----------|----|----|---||||---------------------------- 9 [M] COG2088 Uncharacterized protein, involved in the regulation of septum location 5 9 9 11 -||-----------------|---|-----|-----|----------------|--|||----|-- 13 [M] COG2089 Sialic acid synthase 2 7 9 10 ||-|--|||||||----------------------------------------------------- 10 [S] COG2090 Uncharacterized protein conserved in archaea 4 8 10 16 -------------||---||----------|---|-||----|||-|---|||--|---------- 22 [H] COG2091 Phosphopantetheinyl transferase 3 11 13 15 |||||||||||||||--------------------------------------------------- 15 [J] COG2092 Translation elongation factor EF-1beta 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [K] COG2093 DNA-directed RNA polymerase, subunit E'' 8 10 11 18 ------------|--|-----|-|-|-||||---|||------------|---------||-|-|| 19 [L] COG2094 3-methyladenine DNA glycosylase 9 17 25 37 -||-|||||||||---|--|-||||-----------|-----||||||||-|||||--||||||-- 64 [U] COG2095 Multiple antibiotic transporter 7 12 16 26 ---||||||-|||-------||----||||-----|||--------|--|-----|---|||||-- 29 [S] COG2096 Uncharacterized conserved protein 4 12 14 16 ||||||||||||||||-------------------------------------------------- 17 [J] COG2097 Ribosomal protein L31E 1 7 7 8 ||||||--||-------------------------------------------------------- 8 [S] COG2098 Uncharacterized protein conserved in archaea 6 11 12 16 ||----------------|||------||-|----|----------|--|-----|---||||--- 16 [H] COG2099 Precorrin-6x reductase 2 5 6 7 -|----|||||-|----------------------------------------------------- 7 [R] COG2100 Predicted Fe-S oxidoreductase 4 12 14 16 ||||||||||||||||-------------------------------------------------- 28 [K] COG2101 TATA-box binding protein (TBP), component of TFIID and TFIIIB 4 12 14 16 ||||||||||||||||-------------------------------------------------- 21 [R] COG2102 Predicted ATPases of PP-loop superfamily 4 7 10 18 ------------------||-|--------||--|-||----|||||-|-||--------|-|--- 20 [R] COG2103 Predicted sugar phosphate isomerase 8 18 23 34 |-|||||||-------|-||||----|||||-----||----||--|-||--||||--||-|||-- 36 [H] COG2104 Sulfur transfer protein involved in thiamine biosynthesis 6 10 13 18 -||---|---||------||-|--------------||----|||||-||-----|---------- 18 [S] COG2105 Uncharacterized conserved protein 3 8 10 11 |--|--|||||||||--------------------------------------------------- 12 [S] COG2106 Uncharacterized conserved protein 7 8 10 14 ----||--|-|||---|----|||-------------|------------------|||------- 14 [R] COG2107 Predicted periplasmic solute-binding protein 3 8 10 11 -|||--|||||||-----------------|----------------------------------- 11 [R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme 8 14 16 26 --||||||--|------|||||-----||-------------|||||-||-----|---||||--- 30 [H] COG2109 ATP:corrinoid adenosyltransferase 10 16 20 27 --|-||||||||||--||--||-----||---|-||------|||-|--|-----|------|--- 33 [R] COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 7 13 15 22 ||||--||---------|||-|----|-------||||----------||---------|||--|| 45 [P] COG2111 Multisubunit Na+/H+ antiporter, MnhB subunit 3 5 7 8 -|----|||-|||---|------------------------------------------------- 8 [T] COG2112 Predicted Ser/Thr protein kinase 4 6 8 17 --|----------------------|-----||--||-----|||||--|-----|---||||--- 40 [E] COG2113 ABC-type proline/glycine betaine transport systems, periplasmic components 7 10 11 16 --|----------|||--||----|-||||-------------------|---------||-||-- 102 [T] COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) 3 4 6 14 -----------------|-------------|----||----|||||---|--------||||--- 14 [G] COG2115 Xylose isomerase 5 6 10 19 ---------|---|------|---------|||||||-----|||||-||||-------------- 35 [P] COG2116 Formate/nitrite family of transporters 1 5 5 6 ||||--||---------------------------------------------------------- 6 [J] COG2117 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain 3 11 13 15 |||||||||||||||--------------------------------------------------- 15 [R] COG2118 DNA-binding protein 5 9 10 11 ---|---------||---||-------||-------------------||-----|-------|-- 16 [S] COG2119 Predicted membrane protein 8 12 12 22 --|---||-|-|-|||-----|----||||----|-||----|--|-------------||||--- 39 [S] COG2120 Uncharacterized proteins, LmbE homologs 3 4 6 10 ----------------|---|-----------------------------------|||--||||| 11 [S] COG2121 Uncharacterized protein conserved in bacteria 2 6 6 6 |||-----||----------------------------------------------------|--- 6 [S] COG2122 Uncharacterized conserved protein 4 10 12 14 |-|-||||||||||||-------------------------------------------------- 17 [J] COG2123 RNase PH-related exoribonuclease 7 13 15 22 ---|---------||---||-|----|||||-----||-----------|--|--|--||||||-- 98 [Q] COG2124 Cytochrome P450 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG2125 Ribosomal protein S6E (S10) 4 12 13 15 ||||||||||-|||||-------------------------------------------------- 16 [J] COG2126 Ribosomal protein L37E 5 9 14 27 ------------------||-|----|||||-----------|||||-||--||||||||||||-- 32 [S] COG2127 Uncharacterized conserved protein 6 10 14 27 --|-----|----------|-|----|||||--||-||----|||||--|---|||---|||||-- 59 [S] COG2128 Uncharacterized conserved protein 4 9 11 12 |||---|||||||---|-------------------------------------------|----- 15 [R] COG2129 Predicted phosphoesterases, related to the Icc protein 5 8 10 14 ---|---------||----|--------------|-|-----|||-|--|-----|------||-- 16 [R] COG2130 Putative NADP-dependent oxidoreductases 8 15 16 23 --|-||||||---||--|--||--|-----||||||||-|--------|----------------- 25 [F] COG2131 Deoxycytidylate deaminase 8 12 17 29 ---|------|--||-|--|------|||-------||----|||||--|||||||--||||||-- 54 [Q] COG2132 Putative multicopper oxidases 7 10 13 20 ----------|-------||-|---|-|||-------|----|||-|--|--|--|---||-||-- 30 [G] COG2133 Glucose/sorbosone dehydrogenases 2 3 3 10 ---------------------------|||------------|||||---------||-------- 10 [I] COG2134 CDP-diacylglycerol pyrophosphatase 6 7 8 17 ---|---------|-----|------||||------|-----|||-|--|---------||||--- 28 [S] COG2135 Uncharacterized conserved protein 4 10 12 13 |||---||||||||||-------------------------------------------------- 16 [JA] COG2136 Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain 7 10 15 29 -----------------|--||--|-||||||||||||----|||||-||||-|||---|------ 29 [R] COG2137 Uncharacterized protein conserved in bacteria 7 13 14 18 ||||----||||------||-|----|||-----|-||-----------------|---------- 26 [S] COG2138 Uncharacterized conserved protein 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG2139 Ribosomal protein L21E 4 8 8 11 --|---|||---------|-----------------|---------|--------|---||-|--- 14 [GR] COG2140 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes 7 15 19 33 ||||----||-|-------|-|----||||--||||||-|--|||||--|--|--|---|||||-- 165 [C] COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases 5 8 14 26 ----||--|---|--------|-----|||------------|||||-||--||||---||||||| 26 [C] COG2142 Succinate dehydrogenase, hydrophobic anchor subunit 3 3 3 4 ----------------||--------------------------------------||-------- 5 [O] COG2143 Thioredoxin-related protein 2 5 5 5 |||------|--------|----------------------------------------------- 8 [R] COG2144 Selenophosphate synthetase-related proteins 5 11 13 23 --|---|||----||-----------|---||-|||||----|||-|---||----||-|------ 24 [H] COG2145 Hydroxyethylthiazole kinase, sugar kinase family 8 13 17 27 --||||----||--|---||-|----||------|-||----|||||--|--|--|---||-||-- 51 [PR] COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG2147 Ribosomal protein L19E 8 13 20 30 ---|-------------|||||----|---|--||-||----|||-|-||||||||--||||||-- 57 [M] COG2148 Sugar transferases involved in lipopolysaccharide synthesis 4 5 5 10 ----------------|-||------|||-------------|||-|------------------- 10 [S] COG2149 Predicted membrane protein 1 6 6 8 |-|||||||--------------------------------------------------------- 12 [R] COG2150 Predicted regulator of amino acid metabolism, contains ACT domain 7 14 19 32 |||-||||-||||----|---|----||||-|||||||----|---------|--|---|||||-- 43 [R] COG2151 Predicted metal-sulfur cluster biosynthetic enzyme 6 7 7 8 --|---||----|---||-----------------|---------|-------------------- 12 [G] COG2152 Predicted glycosylase 5 6 9 14 --------------|---|-------|||--|-----|----|||-|-||-----------|---- 14 [R] COG2153 Predicted acyltransferase 7 11 15 20 ---|------||-||-|-||------||||------------------||--|--|----||||-- 22 [H] COG2154 Pterin-4a-carbinolamine dehydratase 4 5 6 9 --|-------------------||------|-----||----------------------|-|-|- 10 [S] COG2155 Uncharacterized conserved protein 6 11 13 22 ---|||------------||-|-----||-|---||------|||||--|-----|---||-||-- 25 [P] COG2156 K+-transporting ATPase, c chain 4 10 12 13 |||---||||||||||-------------------------------------------------- 15 [J] COG2157 Ribosomal protein L20A (L18A) 2 6 6 6 |||-----||--------------------|----------------------------------- 6 [R] COG2158 Uncharacterized protein containing a Zn-finger-like domain 6 9 11 17 ---|--||-|-||-----|-------|||-|---||-----------------------||-||-- 30 [R] COG2159 Predicted metal-dependent hydrolase of the TIM-barrel fold 3 5 5 10 -----------------|------------|-----||----|||||-------------|----- 11 [G] COG2160 L-arabinose isomerase 6 8 11 15 ---|-------------|||-------||----||-------|||-|-|----------|-----| 30 [D] COG2161 Antitoxin of toxin-antitoxin stability system 3 4 6 12 ---------------------------||-----|-||----|||-|--|------------||-- 14 [Q] COG2162 Arylamine N-acetyltransferase 5 10 12 13 ||----||-|||||||--------------|------|---------------------------- 22 [J] COG2163 Ribosomal protein L14E/L6E/L27E 2 3 3 3 |-------|--------|------------------------------------------------ 3 [S] COG2164 Uncharacterized conserved protein 8 13 19 30 ----------------||||||||------||||||||----|||||-|||||--|--|---||-- 88 [NU] COG2165 Type II secretory pathway, pseudopilin PulG 5 7 12 22 ------------------||-|||---||-------------|||||-|||||------|||||-- 27 [R] COG2166 SufE protein probably involved in Fe-S center assembly 4 12 13 15 ||||||||||-|||||-------------------------------------------------- 15 [J] COG2167 Ribosomal protein L39E 3 3 6 12 |----------------|------------------------||||||||||-------------- 12 [P] COG2168 Uncharacterized conserved protein involved in oxidation of intracellular sulfur 3 5 10 20 ---------------------------||--|---|||----|||||-||-----|---|||||-| 25 [F] COG2169 Adenosine deaminase 4 6 7 12 ---|--------------||------|||-------------|||-|--|-----|---------- 12 [S] COG2170 Uncharacterized conserved protein 5 9 17 37 ---------|-------|--------||||||-|||||----|||||||||||||||||||||||| 38 [E] COG2171 Tetrahydrodipicolinate N-succinyltransferase 6 8 8 13 -----------------|||-|||---||-|---||||---------------------------- 28 [T] COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase) 3 5 6 10 ------------------||-------||-------------|||-|---------------||-- 10 [M] COG2173 D-alanyl-D-alanine dipeptidase 4 8 10 11 ||----||-|||||||-------------------------------------------------- 13 [J] COG2174 Ribosomal protein L34E 3 6 8 13 -------------||------------|||------------||||--||-----|------|--- 24 [Q] COG2175 Probable taurine catabolism dioxygenase 3 5 6 14 -----------------|--|---------||||||||||||------------------------ 14 [L] COG2176 DNA polymerase III, alpha subunit (gram-positive type) 6 9 15 31 -------------------|||----||||||||-|||----|||||-|||||||----|||||-- 32 [D] COG2177 Cell division protein 3 7 9 10 -||---|||||||-|--------------------------------------------------- 10 [J] COG2178 Predicted RNA-binding protein of the translin family 4 5 6 11 -----------------|||-|---------|||||||---------------------------- 12 [R] COG2179 Predicted hydrolase of the HAD superfamily 5 7 9 15 --------|-|-|-------------|||-----|-|-----|||-|--|-----|-----|---- 21 [C] COG2180 Nitrate reductase delta subunit 5 7 8 14 --------|-|---------------|||-----|-|-----|||-|--|-----|-----|---- 22 [C] COG2181 Nitrate reductase gamma subunit 6 8 12 22 ----|-||--|||----|---|---------|||||||----|||||-|----------|------ 29 [G] COG2182 Maltose-binding periplasmic proteins/domains 8 13 19 33 -------------|||---||---|-|---|||||||||---|||||-||||||||---||||--- 33 [K] COG2183 Transcriptional accessory protein 3 6 9 17 ---------------------------||----|--------|||-|--||-|||-||-||-|--- 17 [D] COG2184 Protein involved in cell division 7 12 14 24 ---||||||--||-------||----||||-------|----|||----------|---|||||-- 36 [I] COG2185 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) 4 7 12 26 ---------------------|----|||||----|||----|||||-||||-|||---|||||-- 126 [K] COG2186 Transcriptional regulators 4 6 7 8 ----------------|-||-------||--------------------|------------||-- 8 [S] COG2187 Uncharacterized protein conserved in bacteria 5 9 13 28 -------------------|-|----|||-||||||||||--|||||-||-----|---|||||-- 121 [K] COG2188 Transcriptional regulators 5 10 13 17 -----|--|-----------|-----|------|-|--||------|---|||-|-||-|--|--- 33 [L] COG2189 Adenine specific DNA methylase Mod 5 9 13 26 --------------------|----||---||||||||-|||||||||||||---|-------|-- 58 [G] COG2190 Phosphotransferase system IIA components 2 6 6 8 |-|-|||||------------|-------------------------------------------- 12 [C] COG2191 Formylmethanofuran dehydrogenase subunit E 4 8 8 10 -|----||-|--------|--|---------------------------|-----|----|-|--- 14 [O] COG2192 Predicted carbamoyl transferase, NodU family 3 6 11 21 ------------------||-------|||------------|||||-||--||||---|||||-- 26 [P] COG2193 Bacterioferritin (cytochrome b1) 1 4 9 20 ------------------------------------------|||||-|||||||-||||||--|| 48 [R] COG2194 Predicted membrane-associated, metal-dependent hydrolase 6 9 13 23 --|-----------------||---|----||||||||----|||||-|-||------|-|--|-- 39 [E] COG2195 Di- and tripeptidases 5 9 16 32 ------------------||-|----|||-||||||||----|||||-||||||||---|||||-- 199 [TK] COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 3 6 9 14 -------------||---||----------------------|||||-||||----------|--- 52 [T] COG2198 FOG: HPt domain 8 12 16 29 ----------------||||-|--|-|||||---||||----|||||-||--|--|---|||||-- 359 [T] COG2199 FOG: GGDEF domain 7 11 16 29 ----------------|-||-|---||||||----|||----|||||-||--|--|---||||||| 227 [T] COG2200 FOG: EAL domain 6 13 17 26 --||--|||--------|-|----||----|-----||----|||||-||--|--|--|||-||-- 39 [NT] COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain 11 19 23 36 |-||----|-----|-||||-|||-||||||----|||----|||||-||--|--|--||||||-- 446 [T] COG2202 FOG: PAS/PAC domain 9 16 19 28 |-||----|-----|-||||-|-----||||---|-||----|||---||-----|---|||||-- 172 [T] COG2203 FOG: GAF domain 6 9 16 29 ----------------|---|-||||-----------|----|||||-||-||||||||||||||| 89 [T] COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains 5 10 13 21 ------------------||-|-----||-|---||------|||||-||-----|--|||-||-- 23 [T] COG2205 Osmosensitive K+ channel histidine kinase 7 10 11 13 ----------------||-|-|--||----|------|----------||-----|---|--|--- 35 [T] COG2206 HD-GYP domain 6 11 18 33 -----------------||||-----|||-||-|||||----|||||-||||||||--||||||-- 427 [K] COG2207 AraC-type DNA-binding domain-containing proteins 8 11 12 18 -----------------||||-|||--||-|---||||----------||----------|-|--- 33 [TK] COG2208 Serine phosphatase RsbU, regulator of sigma subunit 2 3 6 9 ----------------------||---------------------|--||||-||----------- 10 [C] COG2209 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE 5 8 9 11 --||||--|-||----|---|-------------|-|----------------------------- 22 [S] COG2210 Uncharacterized conserved protein 4 7 8 12 ------------------|||---------||----|-----|||||----------------|-- 42 [G] COG2211 Na+/melibiose symporter and related transporters 6 10 12 18 |-||--||---------|---|----|-------||||----------||---------|||--|- 23 [P] COG2212 Multisubunit Na+/H+ antiporter, MnhF subunit 2 4 7 16 ------------------------------|--|||||-||-|||||||--|-------------- 20 [G] COG2213 Phosphotransferase system, mannitol-specific IIBC component 9 15 19 30 ---|---------|||-|||-|--||----|---------|||||-|-||--|||-||||||||-- 100 [O] COG2214 DnaJ-class molecular chaperone 4 6 7 15 -|------------------|---|-----------------|||||---||---|---||||--- 17 [R] COG2215 ABC-type uncharacterized transport system, permease component 6 12 14 23 ---|||------------||-|-----||-|---||------|||||--|-----|--|||-||-- 26 [P] COG2216 High-affinity K+ transport system, ATPase chain B 13 25 33 54 |-||||-||-|||||-|||||||||-|||||||||||||---|||||-||||-|||||||||||-- 150 [P] COG2217 Cation transport ATPase 1 5 5 5 |||-----||-------------------------------------------------------- 10 [C] COG2218 Formylmethanofuran dehydrogenase subunit C 4 12 14 16 ||||||||||||||||-------------------------------------------------- 16 [L] COG2219 Eukaryotic-type DNA primase, large subunit 10 22 30 45 ||||||||||||||---|||||----|||-|-||||||----|||||-||-||--|--|||||--| 81 [R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold 4 8 8 8 |||-----|||-------------------|---------------|------------------- 14 [C] COG2221 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits 6 10 14 24 |-----||-|-------|--||--------|-||-||-----|||||--|--|------|||||-- 33 [M] COG2222 Predicted phosphosugar isomerases 4 6 8 17 ----------------|---------||||----|-||----|||-|--|-----|----||-|-- 33 [P] COG2223 Nitrate/nitrite transporter 6 9 12 22 -----------|-||------|----||||-------|----|||||-||-----|---|||||-- 26 [C] COG2224 Isocitrate lyase 6 8 12 22 ----------||-|-------|----||||-------|----|||||-||-----|---|||||-- 26 [C] COG2225 Malate synthase 12 18 26 45 --|-||----||-||-||||||||--||||----||||----|||||-||-||||||||||||||| 52 [H] COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis 4 8 15 24 -------------||---||-|--------------------|||||-||-|||||---||||||| 26 [H] COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase 6 9 9 11 ||-------|---||-|----|-----||------------------------||----------- 12 [R] COG2229 Predicted GTPase 6 9 12 24 --|-------------|----|----|||||-----------|||||-||-----|||||||||-- 59 [M] COG2230 Cyclopropane fatty acid synthase and related methyltransferases 6 9 9 13 |||-||-----|----||----------------||--------------------|||------- 13 [L] COG2231 Uncharacterized protein related to Endonuclease III 1 5 5 5 |||-----||-------------------------------------------------------- 5 [R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase 8 11 16 29 -------|------|--|--||----|---||||||||----|||||-||||-|||---|||---- 69 [F] COG2233 Xanthine/uracil permeases 7 15 18 24 |-||--||||---||-|--|-------||-|-----||----|||-|-||--|----------|-- 41 [R] COG2234 Predicted aminopeptidases 6 9 12 18 ---|||-----|-------------|-||--|||||----|-----|-||----------|-|--- 21 [E] COG2235 Arginine deiminase 7 13 16 22 --|||||||-|||||----|----|||--------------------------||||||------- 30 [R] COG2236 Predicted phosphoribosyltransferases 2 7 9 11 -||||||||-|||----------------------------------------------------- 12 [S] COG2237 Predicted membrane protein 4 12 14 16 ||||||||||||||||-------------------------------------------------- 18 [J] COG2238 Ribosomal protein S19E (S16A) 9 14 19 31 |----------------||||-|||||||-|---|-||||-----|--||--|||----||||||| 43 [P] COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain) 6 9 12 20 -------------||------|---||---|-|---------|||||--|||-------|||||-- 26 [H] COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase 7 17 19 25 ||||||--||||------|||-----|||-|----|----------|--|-----|---||||--- 25 [H] COG2241 Precorrin-6B methylase 1 7 16 18 24 ||||||--||||------|||-----|||-|----|----------|--|---------||||--- 26 [H] COG2242 Precorrin-6B methylase 2 7 17 19 24 ||||||--||||------|||------||-|----|----------|--|-----|---||||--- 26 [H] COG2243 Precorrin-2 methylase 9 19 26 42 ||||||||||-|-----|-|||----|---||||||||----|||||-||||||||---|||||-- 113 [R] COG2244 Membrane protein involved in the export of O-antigen and teichoic acid 3 4 5 6 -|----||--|-|----|------------------------------------------------ 7 [S] COG2245 Predicted membrane protein 6 14 19 28 ---||||||||||-----||------||||||-||||-----|---|--|-----|------||-- 37 [S] COG2246 Predicted membrane protein 2 3 3 4 -|----||----------------------------|----------------------------- 9 [M] COG2247 Putative cell wall-binding domain 2 5 7 8 -|----|||||||----------------------------------------------------- 8 [R] COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily) 5 10 15 26 --|-----------|-----|---------|----||||---|||||-||||-||||||-|-||-- 56 [R] COG2249 Putative NADPH-quinone reductase (modulator of drug activity B) 3 6 8 9 -|----|||||||----|------------------------------------------------ 42 [S] COG2250 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN 4 5 5 9 ------||---------|||------||||------------------------------------ 9 [R] COG2251 Predicted nuclease (RecB family) 10 18 24 40 -|-|--||------|--|||||--|||---||||||||-|--|||||-||||-||||||-||-|-- 69 [R] COG2252 Permeases 2 3 3 5 ---|--||-------------------||------------------------------------- 9 [S] COG2253 Uncharacterized conserved protein 2 4 6 7 -|----|||-|||----------------------------------------------------- 11 [L] COG2254 Predicted HD superfamily hydrolase, possibly a nuclease 9 15 23 48 -----------------||||||||||||||||||||||||||||||-|||||||||||||||||| 49 [L] COG2255 Holliday junction resolvasome, helicase subunit 7 13 20 39 -------------||--|--||----|||||||||||||---|||||-||||||||||||||||-- 40 [L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase 4 7 7 10 -----------------|------|-----|-----||-----------|------|||----|-- 11 [S] COG2257 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB 4 8 10 19 ---------------------|----|||-|---||||----|||-|--||----|--||-|---- 25 [S] COG2258 Uncharacterized protein conserved in bacteria 8 11 16 30 ---|-------|-||----|-|----||||----|-||----|||||-||||-|||---|||||-- 67 [S] COG2259 Predicted membrane protein 3 11 13 15 |||||||||||||||--------------------------------------------------- 15 [J] COG2260 Predicted Zn-ribbon RNA-binding protein 5 7 10 23 -------------------|-|----||||-||||-|-----|||||--|-----|---|||||-- 43 [S] COG2261 Predicted membrane protein 11 19 28 46 -|||--||-||||---||||||||--||||||||||||----|||||-||-|||||---|||||-- 49 [R] COG2262 GTPases 3 10 12 14 |||||||||||||--|-------------------------------------------------- 15 [J] COG2263 Predicted RNA methylase 7 12 19 35 ----------------||||||--------||||||||----|||||-||||||||||||||||-- 37 [J] COG2264 Ribosomal protein L11 methylase 11 17 24 42 ------||-----||-||||||||--|||-||||||||----|||||-||||||||--||||||-- 67 [J] COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [H] COG2266 GTP:adenosylcobinamide-phosphate guanylyltransferase 9 14 19 33 -------||----||--|-|||----||||||--||||----|||||-||||---|---|||||-- 54 [I] COG2267 Lysophospholipase 4 6 8 12 ------------------||------|----|----||----|||-|--|------------|--- 14 [S] COG2268 Uncharacterized protein conserved in bacteria 3 4 8 16 ----------------|-------|-----------------|||||||-|||------||-||-- 16 [J] COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) 5 7 8 16 -------------||-|---------|||||----|||---------------------|||||-- 17 [R] COG2270 Permeases of the major facilitator superfamily 3 5 9 18 ----------------------||-------||-|-|-----|||||-||||------|-----|| 37 [G] COG2271 Sugar phosphate permease 5 8 8 11 --------------|------|----|||-|---|-|---------|--------|-------|-- 15 [I] COG2272 Carboxylesterase type B 5 7 8 12 -------------||--|---------||-|-----||---------------------||-||-- 22 [G] COG2273 Beta-glucanase/Beta-glucan synthetase 3 8 14 24 ------------------||----------||-|--||||||-||||-||--||||----|-||-- 44 [V] COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain 7 9 14 24 ---|-------||-------||----|||--||---------|||||-|||----|---|||||-- 41 [G] COG2301 Citrate lyase beta subunit 4 5 6 11 ------------------||||---------|||||||---------------------------- 11 [S] COG2302 Uncharacterized conserved protein, contains S4-like domain 6 12 14 22 ||-|-----|---------|-|-----|||----|-------||||---|-----|--||||||-- 74 [E] COG2303 Choline dehydrogenase and related flavoproteins 9 12 15 21 --|-----|--||-----||||---|||||------||----|--||-||------------|--- 35 [R] COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain 4 4 4 7 ------||-------------|----|||-----|------------------------------- 7 [S] COG2306 Uncharacterized conserved protein 4 6 7 11 ------------------|--|-----|||-------------------|-----|---||-||-- 18 [S] COG2307 Uncharacterized protein conserved in bacteria 5 7 8 12 -----------|------|--|-----|||-------------------|-----|---||-||-- 19 [S] COG2308 Uncharacterized conserved protein 7 9 10 16 ---|--|--|--|---|----|---|-------|||||---------------------||||--- 24 [E] COG2309 Leucyl aminopeptidase (aminopeptidase T) 4 5 5 7 ------------------|--|--------|-----|------|||-------------------- 33 [T] COG2310 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 5 6 7 12 ---|-----------------|----|---------||----|||||-----|----------|-- 20 [S] COG2311 Predicted membrane protein 5 5 6 8 ---|-----------------|-----||-------||----------------------|--|-- 9 [R] COG2312 Erythromycin esterase homolog 5 6 6 11 --------------|--|---|------------||------|||--------------||-|--- 11 [Q] COG2313 Uncharacterized enzyme involved in pigment biosynthesis 7 10 11 14 -||---------------||-|---|-||--|--|-||-----------|-----|---------- 24 [S] COG2314 Predicted membrane protein 5 7 10 18 --------------------||----|----|||-||-----|||||--|-----|---|--||-- 23 [S] COG2315 Uncharacterized protein conserved in bacteria 3 3 3 3 --------|--------|---|-------------------------------------------- 3 [R] COG2316 Predicted hydrolase (HD superfamily) 6 8 12 15 ---|--||--|||-------||-------------|||-------|--|-------------|--| 15 [E] COG2317 Zn-dependent carboxypeptidase 4 5 5 9 ------------------|--|--------------||-----------|---------||||--- 18 [S] COG2318 Uncharacterized protein conserved in bacteria 8 11 12 15 --|----------|||-|||||--------------------------|----------|||||-- 289 [R] COG2319 FOG: WD40 repeat 5 6 7 10 --||-----------------|-----|||------||----------||---------------- 10 [S] COG2320 Uncharacterized conserved protein 4 6 8 17 ---------------------|----|||---|---------|||||--|-|---|---||||--- 19 [R] COG2321 Predicted metalloprotease 4 4 4 7 ---|------------|----|------------||||---------------------------- 8 [S] COG2322 Predicted membrane protein 5 7 8 13 -------------------|||--------||-|--||----|||-|-------------|----- 30 [S] COG2323 Predicted membrane protein 3 5 5 5 |--|--------------||-|-------------------------------------------- 5 [S] COG2324 Predicted membrane protein 5 9 11 16 --|---------------||-|----|||-------------------||-----|--||||||-- 24 [S] COG2326 Uncharacterized conserved protein 6 8 8 12 |----------------|||-|--------|-----------|||-|------------|-|---- 14 [S] COG2327 Uncharacterized conserved protein 6 9 10 20 ---|||-----||--------|----||||----||||-----------|-----|---||||--- 34 [R] COG2329 Conserved protein involved in polyketide biosynthesis related to monooxygenase 4 4 4 6 -----------------|---|-----|||-------------------------|---------- 6 [S] COG2331 Uncharacterized protein conserved in bacteria 3 4 10 19 --|------------------|--------------------|||||-|||||------||||||| 20 [O] COG2332 Cytochrome c-type biogenesis protein CcmE 5 7 13 24 ---|---------------|-|--------||||||||----|||||-||||||||---------- 30 [R] COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily) 6 8 12 21 --|---------------|-||--------------||----|||||-||---|||---|||||-- 33 [R] COG2334 Putative homoserine kinase type II (protein kinase fold) 6 8 9 12 --|----------||---||-|-----||------------------------------||-||-- 23 [M] COG2335 Secreted and surface protein containing fasciclin-like repeats 4 6 7 10 -------------------|-|---------------|----|||--------|||---|------ 14 [T] COG2336 Growth regulator 5 8 10 19 -------------------|-|-----||-|---||||----|||-------|||----|||---| 41 [T] COG2337 Growth inhibitor 5 6 7 12 ---|--||-----------|-|----|-----||||||---------------------------- 14 [S] COG2339 Predicted membrane protein 10 12 13 19 --------|----|-|---|||---||---|---||||-----------|---------|||||-- 34 [S] COG2340 Uncharacterized protein with SCP/PR1 domains 5 6 6 6 -|-------|-------|--||---------------------------------|---------- 9 [G] COG2342 Predicted extracellular endo alpha-1,4 polygalactosaminidase or related polysaccharide hydrolase 4 6 6 8 ------------------||-|-----||--------------------------|----|-|--- 17 [S] COG2343 Uncharacterized protein conserved in bacteria 3 4 5 10 -----------------|---|--------||||||||---------------------------- 11 [R] COG2344 AT-rich DNA-binding protein 6 7 8 12 ----||------------||-|----||||-------|-------|--|----------------- 19 [K] COG2345 Predicted transcriptional regulator 5 7 8 16 ------------------|--|----||||----|-||-----------------|--||||||-- 20 [R] COG2346 Truncated hemoglobins 4 4 5 7 --|------------------|--||------|||------------------------------- 14 [V] COG2348 Uncharacterized protein involved in methicillin resistance 6 10 15 24 ------------------||||----|---|-----|-----|||||-||||-|||---|||||-- 28 [S] COG2350 Uncharacterized protein conserved in bacteria 4 7 9 16 --------------|------|--------------||----|||-|--|-----|--||||||-- 17 [R] COG2351 Transthyretin-like protein 5 8 12 20 ------------------||-|----|--|--||--------|||||-||||-|||-------|-- 20 [C] COG2352 Phosphoenolpyruvate carboxylase 5 8 13 26 ----||---------------|----|||-----||------|||||-||--|||||||||-||-- 39 [S] COG2353 Uncharacterized conserved protein 3 5 8 13 ---------------------|----|||-------------|||-|-||---|-------|-|-- 13 [S] COG2354 Uncharacterized protein conserved in bacteria 7 9 12 18 ------||--|||-|------|||-----------|-|-----------|-----|---|||||-- 26 [E] COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog 3 3 5 10 ---------------------|--------------|-----||||||||---------------- 10 [L] COG2356 Endonuclease I 4 5 6 13 --------------------||----|||-||||||||---------------------------- 21 [S] COG2357 Uncharacterized protein conserved in bacteria 6 8 11 13 ---|----|---|-----|--|---------------|----------||-|--------||--|| 21 [R] COG2358 TRAP-type uncharacterized transport system, periplasmic component 3 4 4 5 -----------------|---|--------|-----||---------------------------- 8 [S] COG2359 Uncharacterized protein conserved in bacteria 3 7 12 20 ------------------||-|--------------------|||||-||--||||--||||||-- 20 [O] COG2360 Leu/Phe-tRNA-protein transferase 4 6 7 7 -||---------------|--|-------------------------------|-----|---|-- 17 [S] COG2361 Uncharacterized conserved protein 5 6 6 8 ------||----|--------|-------------||------------------|------|--- 8 [E] COG2362 D-aminopeptidase 5 6 10 21 --------------|----|-|------------||||----|||||-||||-------|||||-- 21 [S] COG2363 Uncharacterized small membrane protein 4 5 5 7 ---------------------|----|---|-----||------------||-------------- 9 [S] COG2364 Predicted membrane protein 5 8 11 12 -------------||------|-----||--|---|---------|---|-----|---|---|-- 19 [T] COG2365 Protein tyrosine/serine phosphatase 5 9 12 13 ----||--|-|||-----||-|---------------------------|-----|-----|-|-- 20 [R] COG2366 Protein related to penicillin acylase 6 8 9 16 ------------------||||-----||||||||||----------------------||----- 24 [V] COG2367 Beta-lactamase class A 5 5 8 10 --------|-||---------|--------------||-------||--|-|-------------- 15 [Q] COG2368 Aromatic ring hydroxylase 4 5 7 8 -|-------------------|-------------|--------|-----|-|||----------- 11 [S] COG2369 Uncharacterized protein, homolog of phage Mu protein gp30 4 7 7 8 ----------------|-||-|---------------------------|-----|---|--|--- 8 [O] COG2370 Hydrogenase/urease accessory protein 5 10 12 19 ------------------||-|----|-------|--||----|||---||----|||-||||--- 21 [O] COG2371 Urease accessory protein UreE 4 6 6 13 ---------------------|----|--------|||----|||||--------|----|-|--- 13 [R] COG2372 Uncharacterized protein, homolog of Cu resistance protein CopC 5 7 12 19 -----------------|-|||--------------------|||||--|-||--|---||-|||| 23 [R] COG2373 Large extracellular alpha-helical protein 6 7 8 8 ------------------||-|--|-|-----|---------------||---------------- 8 [R] COG2374 Predicted extracellular nuclease 3 5 7 13 ---------------------|----|||-------------|||-|-||-----|---||----- 21 [P] COG2375 Siderophore-interacting protein 5 7 9 17 -------------||-----||---------|--||-|----||||-----|-------||||--- 45 [G] COG2376 Dihydroxyacetone kinase 4 7 13 22 ---------|--------||-|--------------------|||||-||||||||---|||||-- 22 [O] COG2377 Predicted molecular chaperone distantly related to HSP70-fold metalloproteases 5 9 14 24 --------------------||----|||||---||||----|---|-||--|-||--||||||-- 39 [K] COG2378 Predicted transcriptional regulator 5 8 10 15 ----||||--|||----|---|---------------------------|-----|---||||--- 19 [G] COG2379 Putative glycerate kinase 3 3 3 3 ----------------||---|-------------------------------------------- 3 [S] COG2380 Uncharacterized protein conserved in bacteria 4 5 6 12 ---------------------|----|---|---||||----|||-|--|---------------- 17 [P] COG2382 Enterochelin esterase and related enzymes 3 4 4 5 -|----||----|--------|-------------------------------------------- 5 [S] COG2383 Uncharacterized conserved protein 3 5 6 13 ---------------------|--------|||||||||-||------|----------------- 13 [R] COG2384 Predicted SAM-dependent methyltransferase 4 6 6 7 ------------------||||--------|-----||---------------------------- 13 [D] COG2385 Sporulation protein and related proteins 3 5 10 18 --|-----|------------|--------------------|||||-|||||------|||||-- 19 [O] COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component 7 8 13 19 --------|---|-------||----|----|--||------|||---||-|-------|||||-- 20 [R] COG2388 Predicted acetyltransferase 4 5 5 5 --|-------------|-||-|-------------------------------------------- 5 [R] COG2389 Uncharacterized metal-binding protein 3 6 9 21 ---------------------|--------||||||||----|||||-|--|---|---||||--- 47 [K] COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain 6 11 15 23 ---|||---|||-----|---|------------|-------|||||-||--|--|--|||||--- 48 [R] COG2391 Predicted transporter component 3 5 5 6 ------||||--|--------------------------------|-------------------- 7 [R] COG2401 ABC-type ATPase fused to a predicted acetyltransferase domain 5 8 8 8 ---|---||-|-----|-||-------|-------------------------------------- 13 [R] COG2402 Predicted nucleic acid-binding protein, contains PIN domain 3 5 6 7 |-----||-||-|-----|----------------------------------------------- 8 [R] COG2403 Predicted GTPase 5 6 7 9 --||-------||-------|---------------|-------------------|||------- 9 [R] COG2404 Predicted phosphohydrolase (DHH superfamily) 3 4 4 4 --------|---|-----||---------------------------------------------- 6 [R] COG2405 Predicted nucleic acid-binding protein, contains PIN domain 3 4 6 6 |-|-------|||----|------------------------------------------------ 6 [R] COG2406 Protein distantly related to bacterial ferritins 5 6 8 13 ------||--|-|----|------------|--|--------|||||---|--------------- 15 [G] COG2407 L-fucose isomerase and related proteins 5 6 8 14 ----||----|||--------|----|||||---|||----------------------------- 49 [R] COG2409 Predicted drug exporters of the RND superfamily 2 4 6 6 |-------|||||----------------------------------------------------- 6 [S] COG2410 Uncharacterized conserved protein 2 4 5 6 ------|||||-|----------------------------------------------------- 10 [S] COG2411 Uncharacterized conserved protein 2 7 8 10 --||||||||-||----------------------------------------------------- 10 [S] COG2412 Uncharacterized conserved protein 2 4 5 6 ------||||-||----------------------------------------------------- 7 [R] COG2413 Predicted nucleotidyltransferase 4 8 9 13 -||-|||||-|-|-----------------|-----------|||--------------------- 33 [C] COG2414 Aldehyde:ferredoxin oxidoreductase 2 4 6 7 ------|||||||----------------------------------------------------- 7 [S] COG2419 Uncharacterized conserved protein 7 7 9 11 ------||---||-|--|-|---------------|-|----------------------|--|-- 11 [C] COG2421 Predicted acetamidase/formamidase 6 14 17 21 |-||||--|||||||-----------|-------|----------|---|-----|---||||--- 37 [E] COG2423 Predicted ornithine cyclodeaminase, mu-crystallin homolog 3 5 8 12 -||------||||-----------------------------|||||-|----------------- 15 [R] COG2425 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain 3 4 4 5 ------|||---|------------------------|---------------------------- 5 [S] COG2426 Predicted membrane protein 3 4 6 9 ----||--|-|||---------------------|||----------------------------- 21 [S] COG2427 Uncharacterized conserved protein 3 4 4 5 ------||-|--||---------------------------------------------------- 5 [S] COG2428 Uncharacterized conserved protein 2 4 6 6 ||-|------|||----------------------------------------------------- 7 [S] COG2429 Uncharacterized conserved protein 2 4 5 6 --|---|||-|-|----------------------------------------------------- 7 [S] COG2430 Uncharacterized conserved protein 4 5 9 16 ------||--|||-------|---------------------|||||-|-||-||----------- 16 [S] COG2431 Predicted membrane protein 2 7 9 10 |-||--|||||||----------------------------------------------------- 11 [S] COG2433 Uncharacterized conserved protein 5 6 8 13 ----||----|||----|--|---------------------|||-|-------------|-|--- 21 [C] COG2440 Ferredoxin-like protein 2 3 4 5 ------|||--||----------------------------------------------------- 5 [C] COG2441 Predicted butyrate kinase 5 6 7 8 ------|----||-----||-------||-----------------------|------------- 23 [S] COG2442 Uncharacterized conserved protein 4 12 12 14 ||||||||||--||||-------------------------------------------------- 14 [U] COG2443 Preprotein translocase subunit Sss1 4 8 8 10 |||----||-|-----|-----------------|-||---------------------------- 24 [S] COG2445 Uncharacterized conserved protein 1 8 8 10 ||||||||||-------------------------------------------------------- 10 [S] COG2450 Uncharacterized conserved protein 4 6 6 7 ------||-|--||||-------------------------------------------------- 9 [J] COG2451 Ribosomal protein L35AE/L33A 5 7 7 9 -|--||-|---|-------|-------||-----------------------|------------- 42 [L] COG2452 Predicted site-specific integrase-resolvase 7 10 13 17 -||---||--||-||----|-|----|---------------||||--||---------------- 27 [T] COG2453 Predicted protein-tyrosine phosphatase 3 7 7 8 |||---||-|-|------------------|----------------------------------- 9 [S] COG2454 Uncharacterized conserved protein 1 3 3 4 ||----||---------------------------------------------------------- 4 [S] COG2456 Uncharacterized conserved protein 2 7 7 8 |||---||||-|------------------------------------------------------ 8 [S] COG2457 Uncharacterized conserved protein 4 6 7 8 -------||--------|--|---------||-|---|---------------------------- 10 [S] COG2461 Uncharacterized conserved protein 1 5 5 6 -|||--|||--------------------------------------------------------- 7 [S] COG2469 Uncharacterized conserved protein 6 9 12 23 -------------------|||----|---||||||||||--|||||-|----|||---------- 23 [S] COG2501 Uncharacterized conserved protein 4 5 6 12 --------------------|---|-------||----|---|||||---||-------------- 12 [E] COG2502 Asparagine synthetase A 3 5 6 8 -------------------|------------|-|---|-----------||----||-------- 8 [R] COG2503 Predicted secreted acid phosphatase 4 6 7 14 ---------------------|----||||||||-|||-----------|---------|------ 36 [TQ] COG2508 Regulator of polyketide synthase expression 7 12 14 15 --|---||||||-----||-|---------||-----|----------|--------------|-- 16 [R] COG2509 Uncharacterized FAD-dependent dehydrogenases 3 8 9 12 ||----||-|---------|-------------------------|---|---||----|-|---- 12 [S] COG2510 Predicted membrane protein 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [J] COG2511 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain) 2 5 7 9 --|-|||||-|||----------------------------------------------------- 18 [S] COG2512 Uncharacterized membrane-associated protein/domain 6 8 15 25 ----||----|||------|------|||------|||----|||-|-||--||||----|-||-- 36 [G] COG2513 PEP phosphonomutase and related enzymes 5 5 7 14 ----------|-|--------|----|-----||||||---------------------||||--- 17 [R] COG2514 Predicted ring-cleavage extradiol dioxygenase 5 8 10 15 ------||------|--|-|----------------------|||||-|------|--|---||-- 16 [E] COG2515 1-aminocyclopropane-1-carboxylate deaminase 5 6 6 7 --|---||---|----|||----------------------------------------------- 7 [R] COG2516 Biotin synthase-related enzyme 1 4 4 5 |-----||||-------------------------------------------------------- 5 [R] COG2517 Predicted RNA-binding protein containing a C-terminal EMAP domain 5 14 21 32 ||||--|||||||-|--|------------------------|||||-||--||||||||||||-- 46 [O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase 6 13 15 20 ||-||||||||||||-||--------||||------------------------------------ 20 [J] COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases 4 12 14 16 ||||||||||||||||-------------------------------------------------- 32 [R] COG2520 Predicted methyltransferase 3 5 6 7 -|----||-||-|---------------------------------------|------------- 7 [R] COG2521 Predicted archaeal methyltransferase 2 5 7 8 --||--|||-|||----------------------------------------------------- 13 [R] COG2522 Predicted transcriptional regulator 2 6 8 8 ||||----|-|||----------------------------------------------------- 8 [K] COG2524 Predicted transcriptional regulator, contains C-terminal CBS domains 3 7 8 10 ------------------||--------------|-|------------|-----|--||--|--| 12 [V] COG2602 Beta-lactamase class D 2 3 4 7 -|----------------------------------------|||-|--|--------|------- 8 [R] COG2603 Predicted ATPase 3 3 3 5 ------------------------|-----|-------------------------|||------- 17 [S] COG2604 Uncharacterized protein conserved in bacteria 5 5 5 7 ----||------------|--------||-|---------------------------|------- 9 [R] COG2605 Predicted kinase related to galactokinase and mevalonate kinase 6 8 15 30 ----------|-|------||-----||-|-||||||-----|||||-||||-|||---|||||-- 46 [S] COG2606 Uncharacterized conserved protein 4 8 10 14 ----------------|-||----------|------------------|---|||--||||||-- 14 [R] COG2607 Predicted ATPase (AAA+ superfamily) 11 21 26 36 --||||--|--||||-||||||----|---|||-|||||-------|--|||-|||||-|||---- 59 [P] COG2608 Copper chaperone 3 5 11 21 ---------------------|----||||------------||||||||||||||------||-- 21 [C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component 5 7 12 20 --|-----------------|-----|---|-|-|-||----|||||-||||-|||---------- 51 [GE] COG2610 H+/gluconate symporter and related permeases 4 6 7 7 -|--------------|-------------|-----------------||-----|--|------- 9 [P] COG2703 Hemerythrin 2 3 5 12 ------------------------------|-----------|||||-|-||----|||------- 21 [R] COG2704 Anaerobic C4-dicarboxylate transporter 3 5 7 15 --------------|---------------||-||||-----||||||-|-----|---------- 16 [G] COG2706 3-carboxymuconate cyclase 2 4 5 13 ------------------------------|----|||----|||||---||-||----------- 13 [S] COG2707 Predicted membrane protein 5 9 9 10 |||------|--------|||---------|-----------------------------|-|--- 44 [C] COG2710 Nitrogenase molybdenum-iron protein, alpha and beta chains 3 5 5 6 ------------------|-----------|-----||-----------|-----|---------- 6 [R] COG2715 Uncharacterized membrane protein, required for spore maturation in B.subtilis. 1 2 5 9 ------------------------------------------|||||-||--|----------|-- 11 [E] COG2716 Glycine cleavage system regulatory protein 5 8 11 17 -------------------|-|--|-----|-----------|||||--|-|---|--||||-|-- 18 [S] COG2717 Predicted membrane protein 3 5 7 13 ---|--------------------------|-----||----|||||-||----------|-|--- 13 [S] COG2718 Uncharacterized conserved protein 3 5 7 13 ---|--------------------------|-----||----|||||-||----------|-|--- 13 [S] COG2719 Uncharacterized conserved protein 4 5 5 6 ---------------------|----|---|-----||-----------|---------------- 8 [V] COG2720 Uncharacterized vancomycin resistance protein 4 8 9 17 ----|------|------------------|-----||----|||||--------|--||||||-- 28 [G] COG2721 Altronate dehydratase 5 8 12 24 ----||||--||--------------|---||||||||----|||||-|----------||--|-- 65 [G] COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase 6 9 9 11 ------||-----||--|-|----------|-----||--------------|--|---------- 24 [G] COG2730 Endoglucanase 3 6 8 14 --------------------|---------|--|-----|--|||||-|-||----||-------- 29 [G] COG2731 Beta-galactosidase, beta subunit 2 4 4 8 ------------------------------|-----|-----|||||------|------------ 8 [K] COG2732 Barstar, RNAse (barnase) inhibitor 3 4 5 10 --------------------------|||-|-----------|||-|-----|---------|--- 11 [S] COG2733 Predicted membrane protein 3 4 4 7 -----------------|---|--------|---||||---------------------------- 8 [R] COG2738 Predicted Zn-dependent protease 2 4 5 12 --------------------|---------|||||||||||------------------------- 12 [S] COG2739 Uncharacterized protein conserved in bacteria 6 9 11 25 -------------------|||----||||||||||||||----------------||||||||-- 25 [K] COG2740 Predicted nucleic-acid-binding protein implicated in transcription termination 4 6 6 8 -------------------|-|--------|----||---------------------|-|-|--- 11 [V] COG2746 Aminoglycoside N3'-acetyltransferase 4 6 8 13 ----------------||------------|-----||----|||||-||-----|---------- 13 [KNU] COG2747 Negative regulator of flagellin synthesis (anti-sigma28 factor) 6 12 18 32 -----------|-||---||-------|||||||-|||----|||||-||-|-|||--||||||-- 63 [E] COG2755 Lysophospholipase L1 and related esterases 6 11 12 18 ----||-------||--|--|---------||||||--|---------|----||-----|-|--- 21 [F] COG2759 Formyltetrahydrofolate synthetase 6 9 11 17 ---|-------|---------|----|---|---||||----------|---|--|---|||||-- 20 [Q] COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis 4 7 10 18 -------------------|------|||-||--||-|----|||-|--|-----|----|-||-- 32 [S] COG2764 Uncharacterized protein conserved in bacteria 3 5 7 13 ---|--------------------------|-----||----|||||-||----------|-|--- 14 [T] COG2766 Putative Ser protein kinase 3 5 5 5 |-|-----|--------|------------|----------------------------------- 6 [R] COG2768 Uncharacterized Fe-S center protein 6 10 11 13 --|-----|-------|-||-|--------------|-----------||-----|---||-|--- 23 [T] COG2770 FOG: HAMP domain 7 11 15 28 ---------||-------||-|----||||||--||||----|||||-||-----|---|||||-- 155 [K] COG2771 DNA-binding HTH domain-containing proteins 8 15 21 37 --|-||--|----||---||||----|||--|||||-|||--|||||-|||--|||---|||||-- 415 [L] COG2801 Transposase and inactivated derivatives 5 8 10 14 --------------|---||-|-----||-------------------||-----|---|||||-- 14 [R] COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease 8 13 20 32 ----------------||||||||------||||||||----|||||-||||||||--|---||-- 48 [NU] COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB 7 9 13 18 ----------------||||||--------|-----------|||||-||--||||---------- 23 [NU] COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT 4 8 10 14 ---------------------|----|---|--|-||-----|||-|--|-----|--|--|---- 20 [P] COG2807 Cyanate permease 4 6 8 9 -------------|-------|--------------||-----------|--|--|------||-- 10 [K] COG2808 Transcriptional regulator 3 3 3 4 ------||----|--------|-------------------------------------------- 4 [V] COG2810 Predicted type IV restriction endonuclease 2 8 8 10 |||||||||------------|-------------------------------------------- 10 [C] COG2811 Archaeal/vacuolar-type H+-ATPase subunit H 10 16 24 50 ----------------|||||||||||||||||||||||||||||||||||||||||||||||||| 55 [L] COG2812 DNA polymerase III, gamma/tau subunits 6 9 14 29 -|----||-|-|-----|---|---------|||||||----||||||||||-------|||||-- 37 [J] COG2813 16S RNA G1207 methylase RsmC 3 6 10 24 --------------------------|||--|--||||----|||||--||||--||||||-|--- 69 [G] COG2814 Arabinose efflux permease 6 7 8 17 -----------------|--||--||||||||||||||---------------------------- 18 [S] COG2815 Uncharacterized protein conserved in bacteria 6 8 12 22 --|----------||------|----|||-|-----------|||||-||||-------|||||-- 23 [L] COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding 3 5 11 27 --------------------------||||-|||||-|----|||||-||||-|||---|||||-- 30 [L] COG2818 3-methyladenine DNA glycosylase 3 7 10 12 ---------------------|--------|--|--|------||-|--|---|----||---|-- 13 [R] COG2819 Predicted hydrolase of the alpha/beta superfamily 6 6 10 16 ---|------|||-----------|----|-||---------|||||-|-||-------------- 20 [F] COG2820 Uridine phosphorylase 2 5 10 20 ------------------||----------------------||||||||||-|||---|||||-- 21 [M] COG2821 Membrane-bound lytic murein transglycosylase 2 3 3 9 ----------------------------------|||-----||||-------||----------- 9 [P] COG2822 Predicted periplasmic lipoprotein involved in iron transport 3 5 10 17 ---------------------|--------|-----------|||||-||||-|||----|---|| 28 [R] COG2823 Predicted periplasmic or secreted lipoprotein 3 6 12 25 --------------------------|----|||-|------|||||-||||-|||||||||||-- 25 [P] COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism 6 8 13 22 ----------------||---|||||----------------|||||-||||-|||-------||| 23 [M] COG2825 Outer membrane protein 3 6 9 16 --------------------------|||--|-|---|-|--|||--------|||---||--|-- 66 [L] COG2826 Transposase and inactivated derivatives, IS30 family 4 6 10 22 ---|----------------|----------|||||||----|||||-||---||-----||||-- 30 [L] COG2827 Predicted endonuclease containing a URI domain 2 4 8 13 ------------------------------------|-----|||---||--||||---||-|--- 13 [S] COG2828 Uncharacterized protein conserved in bacteria 1 3 4 11 ------------------------------------------|||||----|-||-|||------- 11 [M] COG2829 Outer membrane phospholipase A 1 3 3 5 --------------------------------------------------||-||---|------- 5 [S] COG2830 Uncharacterized protein conserved in bacteria 3 7 11 15 ------------------|||----------------------|||---|||||||--|----|-- 42 [U] COG2831 Hemolysin activation/secretion protein 4 6 10 17 --------------------||-----------||-------|||-|-||||-||----|||---- 17 [S] COG2832 Uncharacterized protein conserved in bacteria 1 4 5 9 --------------------------------------------------||-|||--||||---- 10 [S] COG2833 Uncharacterized protein conserved in bacteria 6 13 20 34 -|||----|-------|----|--||----|-----||----|||||-|||||||||||||||||| 44 [M] COG2834 Outer membrane lipoprotein-sorting protein 4 7 15 25 --||------|||-------------||||------------|||||-||-|||||----||||-- 25 [S] COG2835 Uncharacterized conserved protein 4 6 8 11 ---|---------------|----------|-----------------||---||||||------- 11 [S] COG2836 Uncharacterized conserved protein 5 7 11 20 -------------------|-|----|||-----|||-----|||||-||-|-|||------|--- 26 [P] COG2837 Predicted iron-dependent peroxidase 2 4 6 10 --------------------------||||------------------||--|||---|------- 10 [C] COG2838 Monomeric isocitrate dehydrogenase 4 4 4 7 -------------------|-|------------|-||---------------||----------- 7 [S] COG2839 Uncharacterized protein conserved in bacteria 2 4 10 20 ------------------------|-----------------||||||||||||||---|||||-- 25 [S] COG2840 Uncharacterized protein conserved in bacteria 1 4 6 11 ------------------------------------------|||----|-|-||-|||--|---- 11 [S] COG2841 Uncharacterized protein conserved in bacteria 4 5 6 8 -------------------|-|------------||--------|-----|--||----------- 9 [R] COG2842 Uncharacterized ATPase, putative transposase 5 6 8 13 --|------------------|-----||---||-||----------------||-----|-||-- 15 [M] COG2843 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) 2 4 9 20 --------------------------|||-------------|||||-||||-|||---|||||-- 20 [O] COG2844 UTP:GlnB (protein PII) uridylyltransferase 2 4 4 8 ------------------------|----------------------------||---|||||--- 8 [S] COG2845 Uncharacterized protein conserved in bacteria 2 5 7 12 ------------------------------|---|-------|||||---|--|||----|----- 12 [D] COG2846 Regulator of cell morphogenesis and NO signaling 5 8 13 18 ----------|-----|----|----|---------------------||-|-|||--|||||||| 18 [S] COG2847 Uncharacterized protein conserved in bacteria 5 8 11 13 -||------||||-------------|---||-|-|-----------------||----------- 14 [S] COG2848 Uncharacterized conserved protein 4 6 7 10 --------------------|-||------------|--------||--|---||---|------- 38 [S] COG2849 Uncharacterized protein conserved in bacteria 2 3 7 13 ------------------------------------|-----|||||--|||||||---------- 14 [S] COG2850 Uncharacterized conserved protein 3 5 7 10 --------------------------|-----|-|-||-----------|--|||---|------- 12 [C] COG2851 H+/citrate symporter 4 6 8 9 -------------------|-|-------------|------|-------|--||-----|--|-- 12 [S] COG2852 Uncharacterized protein conserved in bacteria 2 5 11 18 --------------------|---------------------|||||-||||||||--|----||| 20 [M] COG2853 Surface lipoprotein 1 4 10 17 ------------------------------------------|||||-||||||||--|----||| 17 [Q] COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component 5 8 13 25 --------|-----------|-----|----|||||------|||||--|||-|||--||||||-- 26 [S] COG2855 Predicted membrane protein 7 10 12 16 -------------------|||---|-||-|--|||||--------------||-|-----|---- 19 [E] COG2856 Predicted Zn peptidase 4 8 13 21 -------------||-|-------------------||----------||--|||||||||||||| 24 [C] COG2857 Cytochrome c1 3 4 5 6 ------------------|------|-----------------||---|---------|------- 8 [S] COG2859 Uncharacterized protein conserved in bacteria 6 9 15 25 ---|------||---------|----|----||---||----|||||-||||---|--||||||-- 32 [S] COG2860 Predicted membrane protein 3 5 8 14 -------------------------|-----------|----|||-|--|||------|||-||-- 14 [S] COG2861 Uncharacterized protein conserved in bacteria 4 7 11 18 --|-------------|----|--------------------|||-||||||---|||||---|-- 19 [S] COG2862 Predicted membrane protein 2 5 9 12 ---------------------|-----------------------|--||-|-||||||-|----- 21 [C] COG2863 Cytochrome c553 3 7 10 15 --|-----|-------|-------------------------|||||-||||---|--|-|----- 20 [C] COG2864 Cytochrome b subunit of formate dehydrogenase 6 7 7 7 --|----|------------||----|-----------|-------------------|------- 13 [K] COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen 5 8 10 16 --|----------||---|-----------------||----|||||--|---|||-------|-- 19 [E] COG2866 Predicted carboxypeptidase 2 5 12 21 -------------||---------------------------|||||-||-|||||---||||||| 21 [I] COG2867 Oligoketide cyclase/lipid transport protein 3 5 6 14 --------------------|---||----|||||||||-||------------------------ 14 [J] COG2868 Predicted ribosomal protein 2 3 6 9 ----------------------||---------------------|--||||-||----------- 9 [C] COG2869 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC 4 7 11 20 -|--------------|---|---------------------||||||-|||-||||||---||-- 25 [M] COG2870 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase 2 3 6 9 ----------------------||---------------------|--||||-||----------- 9 [C] COG2871 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF 8 13 16 21 --|-||||--||||---|--||--------|------|----------||-----|---||||--- 28 [R] COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain 7 13 15 21 --||---------||--|---|----|||-||---|-|-----------|-|---|--|||||--- 25 [E] COG2873 O-acetylhomoserine sulfhydrylase 2 7 8 10 -||||||||--||----------------------------------------------------- 11 [NU] COG2874 Predicted ATPases involved in biogenesis of archaeal flagella 7 17 19 24 ||||||--||||------|||------||-|----|----------|--|-----|---||||--- 24 [H] COG2875 Precorrin-4 methylase 9 12 15 20 ----||-|--|||----|||||||------|-|-||||---------------|------------ 22 [E] COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase 4 7 14 27 ----------------|---|-||------------------|||||-|||||||||||||||||| 27 [M] COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase 4 5 10 17 --|--------------|--|---------------------||||||||||||||---------- 17 [C] COG2878 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB 1 3 5 10 ------------------------------------------|||||--|---|||--|------- 12 [S] COG2879 Uncharacterized small protein 2 4 4 4 -|-----||---|----------------------------------------------------- 18 [S] COG2880 Uncharacterized protein conserved in archaea 1 5 5 5 ||||----|--------------------------------------------------------- 12 [S] COG2881 Uncharacterized protein conserved in archaea 4 6 8 14 -----------------|------|-----|-----||----||||||||-----|---------- 14 [NUO] COG2882 Flagellar biosynthesis chaperone 5 8 14 30 -------------------|-|----||||||||-|||----|||||-|||||||----|||||-- 30 [D] COG2884 Predicted ATPase involved in cell division 7 10 17 33 ----------------|--||-||||-||-------------|||||||||||||||||||||||| 99 [M] COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins 3 6 7 8 ---|--|||-|-|-----||---------------------------------------------- 10 [S] COG2886 Uncharacterized small protein 5 7 9 18 --|---------|-----------|-||||-------------------------||||||||||| 24 [L] COG2887 RecB family exonuclease 2 9 11 13 |||||||||||||----------------------------------------------------- 13 [J] COG2888 Predicted Zn-ribbon RNA-binding protein with a function in translation 14 28 38 66 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| 89 [J] COG2890 Methylase of polypeptide chain release factors 4 5 10 19 -------------------|----|------|-|||||----|||||-|||||--|---------- 19 [M] COG2891 Cell shape-determining protein 2 7 7 8 |||---||||--|----------------------------------------------------- 8 [S] COG2892 Uncharacterized protein conserved in archaea 3 6 11 22 --------------------|---------||||-||-----|||||----|||||---|||||-- 43 [G] COG2893 Phosphotransferase system, mannose/fructose-specific component IIA 7 12 16 28 ----------------||||||--------|----|||----||||||||--||||||-||||--- 28 [D] COG2894 Septum formation inhibitor-activating ATPase 3 5 10 21 --------------------------|||-|-----------||||||||--||||---|||||-- 24 [P] COG2895 GTPases - Sulfate adenylate transferase subunit 1 8 20 26 43 |||||||||||||---|-||-|----|||-|---||||----|||||-||||---|||||||||-- 50 [H] COG2896 Molybdenum cofactor biosynthesis enzyme 9 13 18 28 |--|------|||||-|--|-|----||||-------|----|||||-||-----|---|||||-- 49 [P] COG2897 Rhodanese-related sulfurtransferase 4 6 9 17 --|-----------------------||||-|--|||------------|--|--|---|||||-- 19 [S] COG2898 Uncharacterized conserved protein 4 5 5 9 ---------------------|-----|||-|--------------------|------|||---- 9 [S] COG2899 Uncharacterized protein conserved in bacteria 1 3 7 16 ------------------------------------------|||||-|||||||----||||--- 16 [S] COG2900 Uncharacterized protein conserved in bacteria 1 2 7 14 ------------------------------------------||||||||||||||---------- 14 [KL] COG2901 Factor for inversion stimulation Fis, transcriptional activator 3 5 9 15 -------------||------------|||------------------||--|------||||||| 15 [E] COG2902 NAD-specific glutamate dehydrogenase 1 3 7 13 ------------------------------------------|||||-|||||--|--------|| 14 [S] COG2904 Uncharacterized protein conserved in bacteria 5 5 6 6 --------|-------|---------|----------|----------||---------------- 8 [T] COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains 3 5 9 13 ------------------|---------|-------------||-||-||--||||-------|-- 13 [P] COG2906 Bacterioferritin-associated ferredoxin 2 4 5 8 ---------------------------||-------------------|----||----|--||-- 9 [R] COG2907 Predicted NAD/FAD-binding protein 2 5 11 21 -----------------|------------------------|||||-|||||||||||||-||-- 23 [S] COG2908 Uncharacterized protein conserved in bacteria 3 3 5 10 ---------------------------||-|-----------|||||-||---------------- 13 [K] COG2909 ATP-dependent transcriptional regulator 2 5 7 11 -------------------------------|-|-||-----------||-----|--|||-|--- 11 [R] COG2910 Putative NADH-flavin reductase 1 3 9 19 ------------------------------------------||||||||||||||---|||||-- 19 [S] COG2911 Uncharacterized protein conserved in bacteria 3 5 9 16 -------------------|--||------------------|||||||||||--|-------|-- 16 [S] COG2912 Uncharacterized conserved protein 1 3 10 21 ------------------------------------------||||||||||||||---||||||| 24 [J] COG2913 Small protein A (tmRNA-binding) 1 2 7 14 ------------------------------------------||||||||||||||---------- 14 [S] COG2914 Uncharacterized protein conserved in bacteria 1 1 5 11 ------------------------------------------|||||||||||------------- 11 [R] COG2915 Uncharacterized protein involved in purine metabolism 1 2 5 11 ------------------------------------------|||||||-|||--|---------- 23 [R] COG2916 DNA-binding protein H-NS 1 3 9 19 ------------------------------------------||||||||||-|||----|||||| 19 [D] COG2917 Intracellular septation protein A 2 3 6 11 ------------------------------|----|------||||||||-|-------------- 11 [H] COG2918 Gamma-glutamylcysteine synthetase 4 6 14 34 ------------------------||||||-|||||||----||||||||||||||---||||||| 34 [D] COG2919 Septum formation initiator 3 3 6 12 --------|-|-------------------------------||||||||||-------------- 12 [P] COG2920 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit 1 2 7 14 ------------------------------------------||||||||||||||---------- 14 [S] COG2921 Uncharacterized conserved protein 1 2 4 10 ------------------------------------------|||||||---|||----------- 10 [S] COG2922 Uncharacterized protein conserved in bacteria 3 4 7 13 |-|--------------|------------------------||||||||||-------------- 13 [P] COG2923 Uncharacterized protein involved in the oxidation of intracellular sulfur 1 2 7 14 ------------------------------------------||||||||||||||---------- 14 [CO] COG2924 Fe-S cluster protector protein 1 2 6 12 ------------------------------------------|||||||||||--|---------- 12 [L] COG2925 Exonuclease I 2 2 4 10 --------------------|---------------------|||||||-||-------------- 10 [S] COG2926 Uncharacterized protein conserved in bacteria 1 3 10 20 ------------------------------------------|||||-||||||||---||||||| 20 [L] COG2927 DNA polymerase III, chi subunit 6 8 10 14 ---|---------------||-||-------------|-----------|--||||---||-|--- 14 [S] COG2928 Uncharacterized conserved protein 2 5 8 10 ------------------||--------------------------|-|---|||-----||-|-- 13 [S] COG2929 Uncharacterized protein conserved in bacteria 3 5 5 5 -------------||--|----------------------------------|--|---------- 7 [S] COG2930 Uncharacterized conserved protein 3 6 11 14 ----------------|-||-------------------------|--||--||||---||-||-- 70 [Q] COG2931 RTX toxins and related Ca2+-binding proteins 3 5 10 17 --------------------|----------||-|--------|--|--||||||----|||||-- 33 [K] COG2932 Predicted transcriptional regulator 1 1 4 9 ------------------------------------------|||||--||||------------- 9 [R] COG2933 Predicted SAM-dependent methyltransferase 2 6 9 12 -------------||---------------------------------||--|--|--||||||-- 12 [O] COG2935 Putative arginyl-tRNA:protein arginylyltransferase 4 5 7 10 ------------------|--------||--|--||----------------|-------|-||-- 16 [R] COG2936 Predicted acyl esterases 2 2 6 13 ---------------------------|||------------|||||-|||||------------- 15 [I] COG2937 Glycerol-3-phosphate O-acyltransferase 2 5 12 22 -------------||---------------------------|||||-||||||||---||||||| 22 [S] COG2938 Uncharacterized conserved protein 3 6 6 6 -------------||------|------------------------------|--|-------|-- 10 [E] COG2939 Carboxypeptidase C (cathepsin A) 5 8 8 9 --|----------|||------||----------------------------|--|------|--- 22 [R] COG2940 Proteins containing SET domain 2 5 7 8 -------------||----------------------------------|--|--|-------||| 8 [H] COG2941 Ubiquinone biosynthesis protein COQ7 2 5 7 13 ------------------||----------------------|||-|-----|--|---|||||-- 16 [G] COG2942 N-acyl-D-glucosamine 2-epimerase 1 3 6 9 ------------------------------------------|||-|-||--|--|-------|-- 9 [M] COG2943 Membrane glycosyltransferase 2 4 8 13 -------------------|----------------------|||-|-|---||||---||----| 20 [K] COG2944 Predicted transcriptional regulator 2 5 9 14 ---|----|----------------------------------------|--||||---||||||| 14 [R] COG2945 Predicted hydrolase of the alpha/beta superfamily 2 3 4 5 ------------------------------------|-----------|---|||----------- 10 [L] COG2946 Putative phage replication protein RstA 4 7 8 11 --------------|---||-|---------------------------|--|--|---||||--- 11 [S] COG2947 Uncharacterized conserved protein 1 4 6 11 ----------------------------------------------------|--|||-||||||| 23 [U] COG2948 Type IV secretory pathway, VirB10 components 3 3 5 10 -------------------|-|--------------------|||||-|-||-------------- 14 [S] COG2949 Uncharacterized membrane protein 2 4 10 20 --------------------------|||-------------|||||-||-|||||---|||||-- 40 [M] COG2951 Membrane-bound lytic murein transglycosylase B 2 2 2 4 ----------------|---------------------------------------|||------- 4 [S] COG2952 Uncharacterized protein conserved in bacteria 2 5 5 8 ------------------||--------------------------------|||----||-|--- 10 [S] COG2954 Uncharacterized protein conserved in bacteria 1 2 6 12 ------------------------------------------|||||-|-||||||---------- 12 [G] COG2956 Predicted N-acetylglucosaminyl transferase 3 5 7 10 ---------------------|---------|-|-----------|---|--|---|||----|-- 10 [E] COG2957 Peptidylarginine deiminase and related enzymes 1 3 4 6 -------------------------------------------------|--|--||||------- 6 [S] COG2958 Uncharacterized protein conserved in bacteria 1 2 6 12 ------------------------------------------|||||-||||-|||---------- 12 [H] COG2959 Uncharacterized enzyme of heme biosynthesis 1 3 7 15 ------------------------------------------|||||-||--||||---||||--- 15 [S] COG2960 Uncharacterized protein conserved in bacteria 1 3 10 19 ------------------------------------------|||||-||||||||---|||||-| 19 [R] COG2961 Protein involved in catabolism of external DNA 3 5 9 20 --------------------------|-------||||----|||||-||||---|---|||||-- 24 [R] COG2962 Predicted permeases 6 8 13 26 -----|--------------||----|||--|||||-|----|||||-|||----|---|||||-- 233 [L] COG2963 Transposase and inactivated derivatives 3 6 9 14 --------------------|-----------|---------|||||-||||---|--|-|----- 17 [S] COG2964 Uncharacterized protein conserved in bacteria 1 2 5 11 ------------------------------------------|||||-|-||-|||---------- 11 [L] COG2965 Primosomal replication protein N 6 9 13 22 |------------||-----|-----|||-|--|||-|----|||||-|-|||-----|------- 25 [S] COG2966 Uncharacterized conserved protein 2 4 8 15 ---------------------|--------------------|||||-||--|--|---|||||-- 15 [P] COG2967 Uncharacterized protein affecting Mg2+/Co2+ transport 5 8 11 19 --||--------------||-------||--------|----|||||-|---|------|||||-- 19 [S] COG2968 Uncharacterized conserved protein 1 2 7 13 ------------------------------------------|||||-||||||||---------- 13 [R] COG2969 Stringent starvation protein B 7 8 8 11 ----||-----|-----|-|-|--------|-----------------|-----------|||--- 14 [G] COG2971 Predicted N-acetylglucosamine kinase 3 5 8 12 --------------------|---------|-||||||----------||--|--|---------- 33 [T] COG2972 Predicted signal transduction protein with a C-terminal ATPase domain 2 2 5 10 ----------------------|-------------------|||||-|-|||------------- 10 [K] COG2973 Trp operon repressor 1 2 7 13 ------------------------------------------|||||-||||||||---------- 13 [L] COG2974 DNA recombination-dependent growth factor C 1 2 6 11 ------------------------------------------|||||-|||--|||---------- 12 [S] COG2975 Uncharacterized protein conserved in bacteria 1 2 7 14 ------------------------------------------||||||||||||||---------- 14 [S] COG2976 Uncharacterized protein conserved in bacteria 2 3 5 14 --------------------------||||------------|||||-||---------|-||--- 14 [Q] COG2977 Phosphopantetheinyl transferase component of siderophore synthetase 4 6 8 13 --------------------|-----|-------|--|----||||--|--|-||--------|-- 19 [H] COG2978 Putative p-aminobenzoyl-glutamate transporter 1 3 6 13 ------------------------------------------|||-|-||-|-||----||||--- 13 [S] COG2979 Uncharacterized protein conserved in bacteria 1 2 7 13 ------------------------------------------|||||-||||||||---------- 13 [M] COG2980 Rare lipoprotein B 2 3 6 14 ------------------|-----------------------|||||-||||-------||||--- 14 [E] COG2981 Uncharacterized protein involved in cysteine biosynthesis 1 3 7 15 ------------------------------------------|||||-||---|||----|||-|| 23 [M] COG2982 Uncharacterized protein involved in outer membrane biogenesis 2 3 7 15 -|----------------------------------------|||||-||||-------|||||-- 15 [S] COG2983 Uncharacterized conserved protein 6 8 10 16 ----------------|---|-||--|-----||--------------||-----|---||||-|| 17 [R] COG2984 ABC-type uncharacterized transport system, periplasmic component 4 4 6 11 ---|----------------|-----|---------------|||||-|-||-------------- 17 [R] COG2985 Predicted permease 5 8 12 19 ---|||--------------||----------|-|-||-------||-||-----|---|||||-- 29 [E] COG2986 Histidine ammonia-lyase 5 8 12 18 ---|||--------------||----------|-|-||-------|--||-----|---|||||-- 19 [E] COG2987 Urocanate hydratase 2 3 5 9 ------------------||----------------------|||||-||---------------- 9 [E] COG2988 Succinylglutamate desuccinylase 1 2 5 13 ------------------------------------------|||||-|-||-------|||||-- 17 [S] COG2989 Uncharacterized protein conserved in bacteria 1 4 6 12 ------------------------------------------|||||-|-||-||---|---|--- 15 [S] COG2990 Uncharacterized protein conserved in bacteria 1 2 5 7 ---------------------------------------------|--||||-||----------- 8 [S] COG2991 Uncharacterized protein conserved in bacteria 2 3 4 7 --------------------|---------------------|||-|-|---------|------- 7 [R] COG2992 Uncharacterized FlgJ-related protein 1 4 7 13 ------------------------------------------------||---|||||||||||-- 18 [C] COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit 2 4 5 5 ------------------|-----------------------------|----|-|----|----- 6 [O] COG2994 ACP:hemolysin acyltransferase (hemolysin-activating protein) 1 2 5 11 ------------------------------------------|||||-|-||-|||---------- 18 [S] COG2995 Uncharacterized paraquat-inducible protein A 3 4 6 11 --------------------|---------||||||||----------||---------------- 11 [S] COG2996 Uncharacterized protein conserved in bacteria 3 5 5 5 |---------|-------------------------------------|------|--|------- 5 [H] COG2998 ABC-type tungstate transport system, permease component 1 2 4 8 ------------------------------------------|||-|-|--|-||----------- 8 [O] COG2999 Glutaredoxin 2 4 8 10 13 -------------||---||-------||-------------------||-----|---||-||-- 32 [I] COG3000 Sterol desaturase 4 5 7 11 ------------------||------|-------|-------|||||-|--|-------------- 11 [G] COG3001 Fructosamine-3-kinase 3 3 3 4 ----------------|-----------------|-|-----------|----------------- 4 [S] COG3002 Uncharacterized protein conserved in bacteria 1 3 7 16 ------------------------------------------|||||-|-||----|||-||||-| 18 [P] COG3004 Na+/H+ antiporter 1 3 6 12 ------------------------------------------|||||-||||------|||----- 26 [C] COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [D] COG3006 Uncharacterized protein involved in chromosome partitioning 2 2 5 5 ------------------------------|--------------|--||--|------------- 7 [S] COG3007 Uncharacterized paraquat-inducible protein B 1 2 6 12 ------------------------------------------|||||-||||-|||---------- 19 [R] COG3008 Paraquat-inducible protein B 1 2 5 10 ------------------------------------------|||||-||---|||---------- 10 [S] COG3009 Uncharacterized protein conserved in bacteria 5 7 10 18 --------------------|----||----|||||---|--|||||-|-||---------|---- 20 [G] COG3010 Putative N-acetylmannosamine-6-phosphate epimerase 3 6 10 12 ------------------||--------------|-||-------|--||--|--|------||-- 12 [S] COG3011 Uncharacterized protein conserved in bacteria 3 4 8 13 ---------------------|----|---------------|||||-||||-|-|---------- 13 [S] COG3012 Uncharacterized protein conserved in bacteria 2 2 4 8 -|----------------------------------------|||||-|--|-------------- 8 [S] COG3013 Uncharacterized conserved protein 1 2 2 4 ------------------------------------------------|-------|||------- 4 [S] COG3014 Uncharacterized protein conserved in bacteria 2 2 3 6 ------------------------|-----------------||||--|----------------- 6 [MP] COG3015 Uncharacterized lipoprotein NlpE involved in copper resistance 2 3 4 4 ----------------|-------------------------------||--------|------- 4 [S] COG3016 Uncharacterized iron-regulated protein 1 2 7 13 ------------------------------------------|||||-||||||||---------- 13 [M] COG3017 Outer membrane lipoprotein involved in outer membrane biogenesis 1 2 2 4 ------------------------------------------------|-------|||------- 5 [S] COG3018 Uncharacterized protein conserved in bacteria 3 5 7 7 ----------|-----|-------------------------------||-|------|-|----- 8 [R] COG3019 Predicted metal-binding protein 3 4 7 13 -------------------|-|--------------------|||||-|--|-------|-|||-- 14 [S] COG3021 Uncharacterized protein conserved in bacteria 5 8 13 20 ----------------|---|-----|-----||--------|||||-||||-|||--|----|-| 20 [S] COG3022 Uncharacterized protein conserved in bacteria 2 4 11 20 --------------------|---------------------|||||-||||||||---|||||-| 31 [V] COG3023 Negative regulator of beta-lactamase expression 1 3 8 16 ------------------------------------------|||||-||||-|||----||||-- 16 [S] COG3024 Uncharacterized protein conserved in bacteria 2 4 8 13 --|---------------------------------------|||||-||||---|------||-- 14 [S] COG3025 Uncharacterized conserved protein 1 2 5 10 ------------------------------------------|||||-||||---|---------- 10 [T] COG3026 Negative regulator of sigma E activity 3 6 12 25 -----------------------|------|---||||----|||||-|||||||----||||||| 25 [S] COG3027 Uncharacterized protein conserved in bacteria 1 2 7 13 ------------------------------------------|||||-||||||||---------- 13 [S] COG3028 Uncharacterized protein conserved in bacteria 2 2 4 10 ---------------------------||-------------|||||-|-||-------------- 10 [C] COG3029 Fumarate reductase subunit C 4 7 10 21 --||----------------------||-------|||----|||||-||-|-||----||||--- 22 [R] COG3030 Protein affecting phage T7 exclusion by the F plasmid 2 2 3 3 ----------------|-------------------------|-----|----------------- 4 [U] COG3031 Type II secretory pathway, component PulC 4 4 6 8 ---|--------|-------|---------------------|||---|--|-------------- 10 [E] COG3033 Tryptophanase 2 4 6 15 ----------------|-------------------------|||||-||------|||||||--- 18 [S] COG3034 Uncharacterized protein conserved in bacteria 1 2 5 8 ------------------------------------------|--||-||||-|------------ 8 [S] COG3036 Uncharacterized protein conserved in bacteria 3 4 7 15 --------------------------|-----||||-|-||-|||||-|--|-------------- 22 [S] COG3037 Uncharacterized protein conserved in bacteria 2 4 11 18 ------------------|-----------------------|||||-||-||-||---|||||-| 37 [C] COG3038 Cytochrome B561 3 7 9 14 --||||---------------------||-------------|-----|----|||---||-|--- 86 [L] COG3039 Transposase and inactivated derivatives, IS5 family 2 4 7 11 --------------------------|---------------|||-|-||--------||--||-- 16 [M] COG3040 Bacterial lipocalin 3 5 8 12 -------------------|-------------|--------|||-|-|-|-|---||-|------ 14 [S] COG3041 Uncharacterized protein conserved in bacteria 2 4 6 11 --------|---------------------------------|||||-|----|||------|--- 12 [R] COG3042 Putative hemolysin 1 3 6 12 ------------------------------------------|||||-||||------|||----- 12 [C] COG3043 Nitrate reductase cytochrome c-type subunit 3 4 4 4 -|-------|--|-----------------------------------|----------------- 4 [R] COG3044 Predicted ATPase of the ABC class 1 3 6 14 ------------------------------------------|||||-||---|||---||||--- 14 [S] COG3045 Uncharacterized protein conserved in bacteria 3 5 6 6 |--|--------------|-----------------------------|----------|---|-- 6 [R] COG3046 Uncharacterized protein related to deoxyribodipyrimidine photolyase 1 3 9 16 ------------------------------------------|||||-||-||--|---|-||||| 19 [M] COG3047 Outer membrane protein W 3 3 5 9 --------------------|---------------||----|||-|-||---------------- 9 [E] COG3048 D-serine dehydratase 4 5 7 10 --|---------------|------------|--|-|---------|-|----------|-||--- 11 [M] COG3049 Penicillin V acylase and related amidases 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [L] COG3050 DNA polymerase III, psi subunit 3 3 5 9 --------------------|----------||---------|||-|-|-|--------------- 10 [C] COG3051 Citrate lyase, alpha subunit 3 3 5 9 --------------------|----------||---------|||-|-|-|--------------- 10 [C] COG3052 Citrate lyase, gamma subunit 3 3 5 9 --------------------|----------||---------|||-|-|-|--------------- 10 [C] COG3053 Citrate lyase synthetase 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [R] COG3054 Predicted transcriptional regulator 2 3 5 10 --------------------|---------------------|||||-|-||---------|---- 13 [S] COG3055 Uncharacterized protein conserved in bacteria 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [M] COG3056 Uncharacterized lipoprotein 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [L] COG3057 Negative regulator of replication initiationR 2 3 5 10 ----------------|-------------------------|||||--|||--------|----- 10 [O] COG3058 Uncharacterized protein involved in formate dehydrogenase formation 1 2 4 9 ------------------------------------------|||-|-|-||----||-------- 9 [S] COG3059 Predicted membrane protein 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [KE] COG3060 Transcriptional regulator of met regulon 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [M] COG3061 Cell envelope opacity-associated protein A 1 3 6 12 ------------------------------------------|||||-||||------|||----- 12 [P] COG3062 Uncharacterized protein involved in formation of periplasmic nitrate reductase 1 2 7 9 ---------------------------------------------|--||||||||---------- 9 [NU] COG3063 Tfp pilus assembly protein PilF 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [M] COG3064 Membrane protein involved in colicin uptake 1 1 4 9 ------------------------------------------|||||-|-|||------------- 12 [M] COG3065 Starvation-inducible outer membrane lipoprotein 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [L] COG3066 DNA mismatch repair protein 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [P] COG3067 Na+/H+ antiporter 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3068 Uncharacterized protein conserved in bacteria 1 1 3 7 ------------------------------------------|||-|-|-||-------------- 13 [C] COG3069 C4-dicarboxylate transporter 2 5 12 19 ------------------------------|--|||------|||||-||||-|-|----|-||-| 20 [K] COG3070 Regulator of competence-specific genes 1 2 7 13 ------------------------------------------|||||-||||||||---------- 13 [H] COG3071 Uncharacterized enzyme of heme biosynthesis 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [F] COG3072 Adenylate cyclase 1 2 6 11 ------------------------------------------|||||-|||||--|---------- 11 [T] COG3073 Negative regulator of sigma E activity 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3074 Uncharacterized protein conserved in bacteria 2 2 4 9 ---|--------------------------------------|||||-|-||-------------- 9 [E] COG3075 Anaerobic glycerol-3-phosphate dehydrogenase 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3076 Uncharacterized protein conserved in bacteria 3 4 8 14 --------------------|-----------||--------|||||-|-|-|------||----| 16 [L] COG3077 DNA-damage-inducible protein J 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3078 Uncharacterized protein conserved in bacteria 1 1 5 10 ------------------------------------------|||||-|||||------------- 10 [S] COG3079 Uncharacterized protein conserved in bacteria 2 2 4 10 ---------------------------||-------------|||||-|-||-------------- 10 [C] COG3080 Fumarate reductase subunit D 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [R] COG3081 Nucleoid-associated protein 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3082 Uncharacterized protein conserved in bacteria 1 1 4 9 ------------------------------------------|||||-||||-------------- 10 [R] COG3083 Predicted hydrolase of alkaline phosphatase superfamily 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3084 Uncharacterized protein conserved in bacteria 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3085 Uncharacterized protein conserved in bacteria 3 3 6 11 -----------------|--|---------------------|||||-||||-------------- 12 [T] COG3086 Positive regulator of sigma E activity 1 2 7 13 ------------------------------------------|||||-||||||||---------- 13 [D] COG3087 Cell division protein 2 3 7 15 ---------------------|--------------------|||||--||||------|||||-- 22 [O] COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [S] COG3089 Uncharacterized protein conserved in bacteria 4 5 9 13 --------------------|-----|----------|----|--||-||||-------||--|-- 43 [G] COG3090 TRAP-type C4-dicarboxylate transport system, small permease component 2 2 6 16 -------------------------------|||||||----|||||-||||-------------- 16 [S] COG3091 Uncharacterized protein conserved in bacteria 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3092 Uncharacterized protein conserved in bacteria 4 5 10 13 -------------------||-----|---------------|||---|||-|-------|-||-- 21 [R] COG3093 Plasmid maintenance system antidote protein 1 2 4 10 ------------------------------------------|||||-|-||-||----------- 10 [S] COG3094 Uncharacterized protein conserved in bacteria 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [D] COG3095 Uncharacterized protein involved in chromosome partitioning 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [D] COG3096 Uncharacterized protein involved in chromosome partitioning 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3097 Uncharacterized protein conserved in bacteria 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [S] COG3098 Uncharacterized protein conserved in bacteria 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3099 Uncharacterized protein conserved in bacteria 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [S] COG3100 Uncharacterized protein conserved in bacteria 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3101 Uncharacterized protein conserved in bacteria 1 1 3 8 ------------------------------------------|||||-|-||-------------- 9 [S] COG3102 Uncharacterized protein conserved in bacteria 2 2 5 11 -----------------------------------||-----|||||-||||-------------- 15 [T] COG3103 SH3 domain protein 5 9 12 19 -------------|||----------|---||--|||-----|||||-|---|||--------|-- 32 [E] COG3104 Dipeptide/tripeptide permease 1 1 4 9 ------------------------------------------|||||-||||-------------- 9 [S] COG3105 Uncharacterized protein conserved in bacteria 1 2 4 12 ------------------------------------------|||||-|-||-------||||--- 12 [R] COG3106 Predicted ATPase 1 1 5 10 ------------------------------------------|||||-|||||------------- 10 [R] COG3107 Putative lipoprotein 1 2 5 13 ------------------------------------------|||||-|-||-------|||||-- 19 [S] COG3108 Uncharacterized protein conserved in bacteria 1 1 4 9 ------------------------------------------|||||-||||-------------- 10 [T] COG3109 Activator of osmoprotectant transporter ProP 1 1 3 8 ------------------------------------------|||||-|-||-------------- 9 [S] COG3110 Uncharacterized protein conserved in bacteria 1 1 4 9 ------------------------------------------|||||-||||-------------- 18 [S] COG3111 Uncharacterized conserved protein 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3112 Uncharacterized protein conserved in bacteria 1 2 6 12 ------------------------------------------|||||-|-||||||---------- 12 [R] COG3113 Predicted NTP binding protein (contains STAS domain) 1 1 4 9 ------------------------------------------|||||-||||-------------- 10 [U] COG3114 Heme exporter protein D 1 1 5 10 ------------------------------------------|||||-|||||------------- 10 [D] COG3115 Cell division protein 1 2 6 12 ------------------------------------------|||||||||||--|---------- 12 [D] COG3116 Cell division protein 1 2 7 13 ------------------------------------------|||||-||||||||---------- 15 [S] COG3117 Uncharacterized protein conserved in bacteria 2 4 9 20 --------------------------||||------------|||||-|||||--|---|||||-- 21 [O] COG3118 Thioredoxin domain-containing protein 4 7 10 19 --||---|------|------------||-------------|||||--|||-------|||||-- 54 [P] COG3119 Arylsulfatase A and related enzymes 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3120 Uncharacterized protein conserved in bacteria 3 5 8 14 ------------------|--|--------------------|||||--|--|--|---||-|--| 86 [NU] COG3121 P pilus assembly protein, chaperone PapD 1 1 3 7 ------------------------------------------|||||--|--|------------- 7 [S] COG3122 Uncharacterized protein conserved in bacteria 1 2 4 8 ------------------------------------------|||||-||-----|---------- 8 [S] COG3123 Uncharacterized protein conserved in bacteria 1 1 3 7 ------------------------------------------|||||-||---------------- 7 [S] COG3124 Uncharacterized protein conserved in bacteria 2 4 7 17 ----------------------------------||||----||||||-|--|--|---|-|||-- 20 [C] COG3125 Heme/copper-type cytochrome/quinol oxidase, subunit 4 1 2 4 10 ------------------------------------------|||||-||---------|-||--- 11 [S] COG3126 Uncharacterized protein conserved in bacteria 1 3 6 13 ------------------------------------------|||||-||-----|---|||||-- 13 [Q] COG3127 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component 1 2 5 7 ------------------------------------------|||----|--|---------||-- 7 [S] COG3128 Uncharacterized iron-regulated protein 2 2 4 8 --------------|---------------------------|||||-||---------------- 8 [R] COG3129 Predicted SAM-dependent methyltransferase 1 1 3 7 ------------------------------------------|||||-||---------------- 7 [J] COG3130 Ribosome modulation factor 1 2 5 8 ------------------------------------------|||-|-||--|--|---------- 14 [P] COG3131 Periplasmic glucans biosynthesis protein 1 2 4 8 ------------------------------------------|||||-||------------|--- 8 [S] COG3132 Uncharacterized protein conserved in bacteria 1 2 4 9 ------------------------------------------|||||--|||---|---------- 10 [M] COG3133 Outer membrane lipoprotein 1 1 3 7 ------------------------------------------|||||--|--|------------- 7 [S] COG3134 Predicted outer membrane lipoprotein 3 4 6 11 ---------------------|----|---------------|||-|-||----------|||--- 12 [Q] COG3135 Uncharacterized protein involved in benzoate metabolism 1 2 4 8 ------------------------------------------|||||-||------------|--- 8 [R] COG3136 Uncharacterized membrane protein required for alginate biosynthesis 1 1 3 7 ------------------------------------------|||||-|---|------------- 7 [M] COG3137 Putative salt-induced outer membrane protein 1 2 4 8 ------------------------------------------|||||-||-------------|-- 10 [E] COG3138 Arginine/ornithine N-succinyltransferase beta subunit 1 1 3 7 ------------------------------------------|||||-||---------------- 7 [S] COG3139 Uncharacterized protein conserved in bacteria 1 1 3 8 ------------------------------------------|||||-|-||-------------- 8 [S] COG3140 Uncharacterized protein conserved in bacteria 1 1 3 7 ------------------------------------------|||||-||---------------- 7 [S] COG3141 Uncharacterized protein conserved in bacteria 3 4 9 17 --------------------|----------|||-|------|||||-|--||------||-||-- 18 [P] COG3142 Uncharacterized protein involved in copper resistance 1 2 4 8 ------------------------------------------|||||-||-----|---------- 9 [NT] COG3143 Chemotaxis protein 3 5 7 13 -----------------|------------|-----||----||||||||-----|---------- 14 [N] COG3144 Flagellar hook-length control protein 4 6 10 19 --------------|----|------||||------------|||-|-||--|--|---|||||-- 23 [L] COG3145 Alkylated DNA repair protein 2 5 7 10 ------------------||-----------------------------|--|--|---|||||-- 10 [S] COG3146 Uncharacterized protein conserved in bacteria 1 2 5 9 ------------------------------------------|||||-||--|--|---------- 9 [S] COG3147 Uncharacterized protein conserved in bacteria 1 1 3 7 ------------------------------------------|||||-||---------------- 10 [S] COG3148 Uncharacterized conserved protein 1 2 4 4 ------------------------------------------|-----||-----|---------- 5 [U] COG3149 Type II secretory pathway, component PulM 1 2 5 9 ------------------------------------------|||||-||-|---|---------- 15 [R] COG3150 Predicted esterase 1 1 4 8 ------------------------------------------|||||-||--|------------- 8 [S] COG3151 Uncharacterized protein conserved in bacteria 2 3 7 13 -------------------------------|--||------|||||-||----------|-||-- 30 [S] COG3152 Predicted membrane protein 5 6 10 18 --|----------------|------|----|--||------|||||-||---------|||||-- 32 [R] COG3153 Predicted acetyltransferase 1 3 5 11 ------------------------------------------|||||-||-----|---|||---- 11 [I] COG3154 Putative lipid carrier protein 1 1 3 7 ------------------------------------------|||||-||---------------- 7 [Q] COG3155 Uncharacterized protein involved in an early stage of isoprenoid biosynthesis 1 3 7 8 ------------------------------------------|--|--||--|--|------||-- 9 [U] COG3156 Type II secretory pathway, component PulK 1 3 5 10 ------------------------------------------|||||-||-----|---|--|--- 28 [S] COG3157 Hemolysin-coregulated protein (uncharacterized) 4 6 10 18 --|-----------------------|----||---------|||||-||--|--|---|||||-- 23 [P] COG3158 K+ transporter 1 3 7 11 ------------------------------------------|||||-||-||--|-------|-- 11 [S] COG3159 Uncharacterized protein conserved in bacteria 1 1 3 7 ------------------------------------------|||||-||---------------- 7 [K] COG3160 Regulator of sigma D 3 8 12 19 |||-----||-----------------|||------------|||||-||-|-|||---------- 19 [H] COG3161 4-hydroxybenzoate synthetase (chorismate lyase) 4 4 6 10 ---------------------|----|---------|-----|||||--|--|------------- 10 [S] COG3162 Predicted membrane protein 1 2 5 9 ------------------------------------------|||||-||--|--|---------- 9 [S] COG3164 Predicted membrane protein 1 2 7 12 ------------------------------------------|||||-||-|||||---------- 12 [S] COG3165 Uncharacterized protein conserved in bacteria 2 5 9 14 ------------------||----------------------|||||-||--||||------|--- 15 [NU] COG3166 Tfp pilus assembly protein PilN 1 2 5 6 ------------------------------------------------||--||||---------- 6 [NU] COG3167 Tfp pilus assembly protein PilO 1 2 5 6 ------------------------------------------------||--||||---------- 6 [NU] COG3168 Tfp pilus assembly protein PilP 2 3 5 6 ---------------------|--------------------------||--|-------||---- 6 [S] COG3169 Uncharacterized protein conserved in bacteria 1 2 5 6 ------------------------------------------------||--||||---------- 8 [NU] COG3170 Tfp pilus assembly protein FimV 1 2 4 10 ------------------------------------------|||||--|||-||----------- 11 [S] COG3171 Uncharacterized protein conserved in bacteria 3 3 5 11 ---------------------------||--|----------|||||--|||-------------- 11 [H] COG3172 Predicted ATPase/kinase involved in NAD metabolism 5 8 11 16 --||-----------------|-----||--|---|||-----------|-----|---||-||-| 24 [R] COG3173 Predicted aminoglycoside phosphotransferase 4 9 9 10 |-||-----|--|---|--------------------------------|-----|----|-|--- 14 [S] COG3174 Predicted membrane protein 2 5 7 11 -------------||----------------------------------|-----|---||||||| 11 [O] COG3175 Cytochrome oxidase assembly factor 3 5 7 11 -------------------|-------||-------------------||-----|---|||||-- 14 [R] COG3176 Putative hemolysin 7 11 16 23 --||------------|--||-----|-----|-||-------|||---|-|-|||||-||-|--| 37 [S] COG3177 Uncharacterized conserved protein 1 3 6 10 -------------------------------------------------|--||||---|||||-- 10 [R] COG3178 Predicted phosphotransferase related to Ser/Thr protein kinases 2 3 5 5 ---------------------|------------------------|--||---------|----- 8 [R] COG3179 Predicted chitinase 5 6 8 15 -------------------||-----|-------|-||----|||-|-||---------||-|--- 15 [R] COG3180 Putative ammonia monooxygenase 4 6 9 11 --------------------|-----|---------||--------|-||-|---|---||----- 21 [S] COG3181 Uncharacterized protein conserved in bacteria 3 5 8 10 --------------------------|-------|--|----------||---|||---|---|-- 19 [S] COG3182 Uncharacterized iron-regulated membrane protein 3 4 6 6 --|------------------|------------------------|-||------------|--- 6 [V] COG3183 Predicted restriction endonuclease 1 3 4 8 -------------------------------------------------|--|||----||||--- 8 [S] COG3184 Uncharacterized protein conserved in bacteria 3 6 8 10 ------------------||------|---------------------||-----|---||-||-- 15 [ER] COG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins 2 4 6 6 -----------------------|------------------------||-----|------||-- 6 [E] COG3186 Phenylalanine-4-hydroxylase 6 9 11 20 --|---------------|-||----|---------------|||||-||-----||||||||--- 21 [O] COG3187 Heat shock protein 2 4 7 12 ------------------|-----------------------|||||--|--|--|---|--|--| 70 [NU] COG3188 P pilus assembly protein, porin PapC 5 7 8 17 ----||-----|--------------|||-----|-------|||-|--|-----|---||||--- 17 [S] COG3189 Uncharacterized conserved protein 3 4 6 13 ----------------------||------------||----||||||||-----|---------- 13 [N] COG3190 Flagellar biogenesis protein 5 7 8 15 ------||---|---------|----||||-------------------|-----|---|||||-- 21 [EQ] COG3191 L-aminopeptidase/D-esterase 3 3 4 8 --------------------|--------------||-----|||-|--|---------------- 8 [E] COG3192 Ethanolamine utilization protein 4 6 9 12 ----------||------|----------------|------|---|--|-----|---|-|||-- 16 [R] COG3193 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol 2 4 5 11 -------------||---------------------------|||-|--|---------||||--- 13